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            <taxon>Elateroidea</taxon>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
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                <person name="Al-Wathiqui N."/>
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                <person name="Weng J.K."/>
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        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
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                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Photinus pyralis genome working group"/>
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                <person name="Sander Lower S.E."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
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        <text evidence="1">Belongs to the peptidase C2 family.</text>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
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                <person name="Lewis S.M."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
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    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
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            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">1611_PpyrPB1</strain>
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        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
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        <text evidence="1">Belongs to the IFRD family.</text>
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        <property type="protein sequence ID" value="JAV58044.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="18978at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="entry name" value="Leucine-rich Repeat Variant"/>
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            <begin position="1"/>
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        <source>
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        <source>
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        <source>
            <dbReference type="Pfam" id="PF04836"/>
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        <source>
            <dbReference type="Pfam" id="PF05004"/>
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        <source>
            <dbReference type="EMBL" id="JAV58044.1"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAB0795228.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="428" mass="47660" checksum="BC2FE54A4A90B231" modified="2017-08-30" version="1">MPKGKRKGKSDRRYEGSIQTSDEESVIDNVSLISGYSENTSAEDGITDEVDGFTQQEAFEEKLMEAIDGLTQKSAQGRANSFEAVAKAFIKKYVPDFVQDRKLTIIDCIERSLRKGRGVEQEVSAELAPLLCVQLGVDASNEVVANLKPVLKSTANDNSVSALARAKCCTSLALITYLSGGEMGDVLTLMQQFQVIFSGSYLKGDGSLPNVNSDAATLHAAALSAWTLLFTLMAPGDVYTMIGNGTNFTPSLVQLAQLLASPFLEVRLSAGEALAIVFELGREYHEDFAEEFIPDLVDTLRQLATDSHKYRAKKDRKQQRATFRDILYYIEEDNLQDLQIRFGKEILVLDSWTRRKQYYVLCHTLGSGLNMHLAENELLRDIFQLGNKLIMDTPSLKQSKLERHLVNAAAFKARTISRSKNRDKRSDF</sequence>
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    <reference evidence="1" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
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            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Photinus pyralis genome working group"/>
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                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
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            <dbReference type="EMBL" id="JAV57498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0797340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="151" mass="17855" checksum="8B551DC8A408DC68" modified="2017-08-30" version="1">MTNYIYVIWLNKHNIIIIKHQDFQTCAIHYYDITTQECADQMREEESRLFYNTTHEAKYLLQIGLNEACDMCCCARVLKMAADQRVVSETFVRFIDCLEELMEALVVDVDQTIIQRLQNDTRGFESKNSDFELSKFGFPKYPFSAERLRKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1KCN3</accession>
    <name>A0A1Y1KCN3_PHOPY</name>
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            <fullName evidence="7">Monothiol glutaredoxin-5</fullName>
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    <gene>
        <name evidence="10" type="ORF">PPYR_07009</name>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
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            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
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            <taxon>Elateroidea</taxon>
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    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
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            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01090041">
        <property type="protein sequence ID" value="JAV57375.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01090040">
        <property type="protein sequence ID" value="JAV57376.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1KCN3"/>
    <dbReference type="OrthoDB" id="415696at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glutaredoxin"/>
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        <property type="entry name" value="GRX_PICOT-like"/>
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    <dbReference type="InterPro" id="IPR004480">
        <property type="entry name" value="Monothiol_GRX-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00365">
        <property type="entry name" value="Grx4 family monothiol glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10293">
        <property type="entry name" value="GLUTAREDOXIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10293:SF16">
        <property type="entry name" value="GLUTAREDOXIN-RELATED PROTEIN 5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="8">
        <location>
            <begin position="38"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00067456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00076083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="JAV57375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0799129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="140" mass="15791" checksum="5E8C44EEC5A55576" modified="2017-08-30" version="1">MNILNKSSFIINKTVLLARFATLKPANEIKQLVDKNKVVVFMKGVPEEPRCGFSNAVVQILRMHGVTYDSYDVLQDDALRQGIKEYSKWPTIPQVFINGELIGGCDIMLNMHQSGDLIEELQKAGIKSALLEQKDKKEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1KDP0</accession>
    <name>A0A1Y1KDP0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Phosphatidylserine synthase</fullName>
            <ecNumber evidence="12">2.7.8.29</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Serine-exchange enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PPYR_08241</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) is replaced by L-serine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + L-serine = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + ethanolamine</text>
            <dbReference type="Rhea" id="RHEA:27606"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:57603"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="EC" id="2.7.8.29"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Phospholipid metabolism; phosphatidylserine biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the phosphatidyl serine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.29" evidence="12"/>
    <dbReference type="EMBL" id="GEZM01088045">
        <property type="protein sequence ID" value="JAV58330.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1KDP0"/>
    <dbReference type="FunCoup" id="A0A1Y1KDP0">
        <property type="interactions" value="701"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1KDP0"/>
    <dbReference type="OrthoDB" id="10265393at2759"/>
    <dbReference type="UniPathway" id="UPA00948"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106245">
        <property type="term" value="F:L-serine-phosphatidylethanolamine phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006659">
        <property type="term" value="P:phosphatidylserine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004277">
        <property type="entry name" value="PSS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362:SF15">
        <property type="entry name" value="PHOSPHATIDYLSERINE SYNTHASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03034">
        <property type="entry name" value="PSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="11 12" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="189"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="386"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU368094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="JAV58330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAB0797247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="444" mass="51647" checksum="48CDCE3269C0376C" modified="2017-08-30" version="1">MATVKNKSASLNNLSTTRIRHDSFTSINEKQVDDISLEFFYKPHTITLLGITIVIVIYTAFVRDNGNIENNIWDGILCCIFFFLIISVLAFPNGPFIRPHPAVWRIVFGLSVLYLLAILFLLFQNYKTVRSIFLWLDPNLANFHIDMEKEYGVNCSDITIERVWSHLDIFAVGHYLGWLFKAILIRHNAILWAISCMWEITEIAFAHLLPNFIECWWDAWILDVLVCNGFGIWCGLRICQMLEMREYKWTSIRDIHTTTGKIKRAVLQFTPESWVSVRWLDPKCSYMRVIAFCQLVLFWQISELNTFFLKHVFEMPPSHPIVTGRLILIGVFVAPSVRQYYTYVTDTQCKRVGTQCWVYGCIMVSEALLCIKHGRELFERTQAINIIVWLLIQLLISVLCVIGCVLWDRHFKGQNEASKEVSPVKHKPTVTFADIKRLSMEKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1KHC5</accession>
    <name>A0A1Y1KHC5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mitochondrial fission process protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Mitochondrial 18 kDa protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_03171</name>
        <name evidence="6" type="ORF">PPYR_09658</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MTFP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01087255">
        <property type="protein sequence ID" value="JAV58816.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1KHC5"/>
    <dbReference type="FunCoup" id="A0A1Y1KHC5">
        <property type="interactions" value="380"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1KHC5"/>
    <dbReference type="OrthoDB" id="424969at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019560">
        <property type="entry name" value="Mitochondrial_18_kDa_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11001">
        <property type="entry name" value="MITOCHONDRIAL FISSION PROCESS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11001:SF2">
        <property type="entry name" value="MITOCHONDRIAL FISSION PROCESS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10558">
        <property type="entry name" value="MTP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="JAV58816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0791371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0798665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="166" mass="18480" checksum="04263688E059B0C7" modified="2017-08-30" version="1">MSHSGEIDIYRDTPIRYLGYANEIGEAFRSMIGPKWVAVTYGVATTYVLADTASKTKDAHIQHRGDPKTVSFVAFDTFAWQMLASVVVPGITINRTCAAAGYLLTYNRTLPSTTKKWIVTGIGLTMIPFIIKPIDHLIDRLLDGTLRKYAPEKFDVLKDDPKVKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1KIJ0</accession>
    <name>A0A1Y1KIJ0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sarcosine dehydrogenase, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_07453</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
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    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
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        <text evidence="1">Belongs to the GcvT family.</text>
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        <property type="protein sequence ID" value="JAV60040.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="FunCoup" id="A0A1Y1KIJ0">
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    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1KIJ0"/>
    <dbReference type="OrthoDB" id="498204at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FAO_M"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF01571">
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    </dbReference>
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    </dbReference>
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            <begin position="33"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="FAD dependent oxidoreductase central" evidence="5">
        <location>
            <begin position="392"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="GCVT N-terminal" evidence="3">
        <location>
            <begin position="450"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="domain" description="Aminomethyltransferase C-terminal" evidence="4">
        <location>
            <begin position="781"/>
            <end position="866"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08669"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF16350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="JAV60040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0799573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="894" mass="100464" checksum="9672568926B272E3" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
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    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01080340">
        <property type="protein sequence ID" value="JAV62209.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KAB0797223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1KLD8"/>
    <dbReference type="FunCoup" id="A0A1Y1KLD8">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1KLD8"/>
    <dbReference type="OrthoDB" id="3908708at2759"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of fibroblast growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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        <property type="entry name" value="Ubiquitin-like_domsf"/>
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    </dbReference>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="JAV62209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0797223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="322" mass="36758" checksum="6ECC28AD62D1BC64" modified="2017-08-30" version="1">MMKHVQLSPYRSRADTVSLSSTTSYGSLSPEPLGSRSSSYSSLSESNPQTTIKVYARCLRPDIEYKTLGISFQTTCREVVGTLLGKYKMKHRDPKLFYLSMEVTVRKAGVRTHLALDDEARPAVLQSCHPKGDSKFSLQTKRGGLVKVYDSALNNNSQYKCLLISSQTTSDEVISLLLTCCNSKERVEQFSIYEVCTDKEQQRKLHPDDRPLQVQHSWLPSLNCHFLVRRNPEYSLPLSRRKIYWVPELPPIPSNKRQQLAYRSQLLSRSQNSLLPCRGVEEKIKSTKDSSSNKKSEMNSKQVSLSMAEKPSYADYENYFYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
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    <name>A0A1Y1KMB3_PHOPY</name>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PPYR_05744</name>
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    </gene>
    <organism evidence="14">
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
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            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
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            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
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                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">1611_PpyrPB1</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">1611_PpyrPB1</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 11">
            <text>L-glutamate + NH4(+) + ATP = L-glutamine + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16169"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 10">Belongs to the glutamine synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.2" evidence="3 11"/>
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        <property type="protein sequence ID" value="JAV61726.1"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR050292">
        <property type="entry name" value="Glutamine_Synthetase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20852">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR20852:SF57">
        <property type="entry name" value="GLUTAMINE SYNTHETASE 2 CYTOPLASMIC"/>
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    </dbReference>
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    </dbReference>
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    <feature type="domain" description="GS beta-grasp" evidence="12">
        <location>
            <begin position="30"/>
            <end position="112"/>
        </location>
    </feature>
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        <location>
            <begin position="119"/>
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        </location>
    </feature>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
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    </evidence>
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        <source>
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            <dbReference type="PROSITE" id="PS51987"/>
        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAB0792334.1"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAB0801390.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="369" mass="41592" checksum="0563EEB6A4195A74" modified="2017-08-30" version="1">MPNPTLDHSPNAAINKTVSKKFLDLPVPDGKVQAMYIWIDGSGENLRAKTRTLDFIPENPEELPIWNFDGSSTKQAEGMNSDVYLYPVAIYRDPFRRGNNKLVLCETYKYTKKPTESNRRHSCLKVMQAAADHKPWFGIEQEYTLLDMDLRPLGWPKHGFPGPQGPYYCGVGANKVYGRDIVEAHYRACLYAGINISGENAEVMPAQWEFQVGPCEGIQIGDQLWMARFLLHRVAEEFGVIATLDPKPMEGDWNGAGAHTNFSTKLMREDNGIIEIEKAIDKLSRHHIRHIQAYDPKGGKDNERRLTGRHETSSIHDFSAGVANRSASIRIPRGCAEDKKGYLEDRRPASNCDPYSVVEALVRTCVLDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1KMZ3</accession>
    <name>A0A1Y1KMZ3_PHOPY</name>
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        <recommendedName>
            <fullName evidence="4">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_01495</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
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            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
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        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33198">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33198:SF19">
        <property type="entry name" value="CCHC-TYPE DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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            <dbReference type="EMBL" id="JAV62773.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAB0804525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="216" mass="24912" checksum="86A6D3BCF2191792" modified="2017-08-30" version="1">MNTTPTNTVQQSLNTVQHSFIIEAFNPSTTSWARWVKRLEGAFKVFNTTDDMKVYYILHYMGASTYDILADKLSPVEPESKTYIEIIQTLEHFYSPSPLEVAEIFRFQSRKQVEGESIQEYCHALQKLSINCKFGNYLNNAVRNQLVFGLQSKRIQTRLLETKDLTLEKAMEVASSMEITEKDIQQLQHKGTNVHAKFVPFCSIHINQNPRNTNIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1KQT3</accession>
    <name>A0A1Y1KQT3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sushi domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PPYR_06925</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01081203">
        <property type="protein sequence ID" value="JAV61796.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1KQT3"/>
    <dbReference type="InParanoid" id="A0A1Y1KQT3"/>
    <dbReference type="OrthoDB" id="6127264at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051277">
        <property type="entry name" value="SEZ6_CSMD_C4BPB_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45656">
        <property type="entry name" value="PROTEIN CBR-CLEC-78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45656:SF4">
        <property type="entry name" value="PROTEIN CBR-CLEC-78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
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    </dbReference>
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        <property type="entry name" value="SUSHI"/>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
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            <end position="612"/>
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            <begin position="385"/>
            <end position="406"/>
        </location>
    </feature>
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        <location>
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        <location>
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        </location>
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        <location>
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        </location>
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        <location>
            <begin position="306"/>
            <end position="371"/>
        </location>
    </feature>
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        <location>
            <begin position="505"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="505"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="JAV61796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0799045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="612" mass="66654" checksum="A3F0326D38466B44" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1L019</accession>
    <name>A0A1Y1L019_PHOPY</name>
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        <recommendedName>
            <fullName evidence="3">Enhancer of mRNA-decapping protein 3</fullName>
        </recommendedName>
    </protein>
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        <name evidence="8" type="ORF">PPYR_01008</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
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            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
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                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
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        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EDC3 family.</text>
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        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
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        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13612:SF0">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
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            <end position="181"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS51512"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="JAV67009.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAB0804038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="453" mass="49820" checksum="69C65459FCB6B9BD" modified="2017-08-30" version="1">MSQWVGFMVSVETEDTGTYQGIISSATGSQITLGKAFCNGIPCNSSEVIISAEDITNLQLIEKQESHSGESTVTVAKPIPKRAGRTFSGSEIISCGKSNGTYSYIKSKPIDIEYKSSHQDLSLKSATPKNKSKSKWSKGWRDELCFGSPLENIGKDFDFEKNLALFDKQAIWDEINSQKPDVVRQTDKKNGNKYRHDENVLATVPTVYRQITVPKQEFCEYVTDDGLIIPSISRSLRNKLWCAADVCGLSCERRIELMGRAAAEMTLQLIGGGHRLNPHNTHQCPTVVVLCGRNRQGAMGINAARHLASHGVNTIVYTVSVEAPEVQREIALYKLTKNKIISTASKLPQLVDLIILSLCEDTDNPLCHDDLAAWTNSNKAIVLALDPPSSGTPGIVTKFSLVPVLPLAHSTENGKIYLCNLGFPTQIFYEVGIKYKSPFGSKFVIPLHLNDDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
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            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
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                <person name="Al-Wathiqui N."/>
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                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tubulin--tyrosine ligase family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01066955">
        <property type="protein sequence ID" value="JAV67624.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1L213"/>
    <dbReference type="OrthoDB" id="202825at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070740">
        <property type="term" value="F:tubulin-glutamic acid ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000009">
        <property type="entry name" value="tubulin polyglutamylase TTLL5 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATP-grasp fold, B domain"/>
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    </dbReference>
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        <property type="entry name" value="TTL/TTLL_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12241">
        <property type="entry name" value="TUBULIN POLYGLUTAMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12241:SF161">
        <property type="entry name" value="TUBULIN POLYGLUTAMYLASE TTLL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03133">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
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    </dbReference>
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    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="501"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="JAV67624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0802289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="648" mass="74995" checksum="AC9F4F7D6BD69384" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LAE7</accession>
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        <recommendedName>
            <fullName evidence="10">Hexosyltransferase</fullName>
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        </recommendedName>
    </protein>
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        <name evidence="12" type="ORF">PPYR_09162</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Golgi apparatus membrane</location>
            <topology evidence="1 10">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the glycosyltransferase 31 family.</text>
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    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU363063"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="JAV70603.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAB0798169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="363" mass="42373" checksum="292A37467ED8D5FD" modified="2017-08-30" version="1">MRKFFNTKIKCSKLLAVSILSFLLGAILVTNLFPINKTCRLDNTDREYNIMQNSKLKSPELIILIMSAPKNLERRNAIRETWLKLRNRTNKIFKHYFVIGSFELAADQILHLSSEQSVYSDMLILPMVDSYANLTLKVLNSFIWLNEQLDVGYNFKYVLKCDDDSFVRIDSLLHEIGHIELMYLKSNLTEANLLNDNNSPYLRVNVQYNDKSALRNLNLYWGYFHGRARIQTNGKWTENNWIMCDYYMPYALGGGYIISKDLVHYIATNGKYLRLYQSEDVSVGAWLSVVNNVLRIHDARFDTEWTSRGCQNYHLISHHLSVKLMRSIYNNIEKTGNLCNNESSKRAYYLYDWGVPPSKCCNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LCJ1</accession>
    <name>A0A1Y1LCJ1_PHOPY</name>
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            <fullName evidence="13">RING-type domain-containing protein</fullName>
        </recommendedName>
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        <name type="scientific">Photinus pyralis</name>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
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            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
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                <person name="Al-Wathiqui N."/>
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                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01061266">
        <property type="protein sequence ID" value="JAV70591.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A1Y1LCJ1">
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    </dbReference>
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    <dbReference type="OrthoDB" id="423559at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
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        <property type="project" value="InterPro"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Tandem AAA-ATPase domain"/>
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    </dbReference>
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        <property type="entry name" value="Helicase_ATP-bd"/>
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    </dbReference>
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        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45865:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SHPRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45865">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SHPRH FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21325">
        <property type="entry name" value="SHPRH_helical-1st"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="364"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="1139"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="1217"/>
            <end position="1365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="291"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1404"/>
            <end position="1441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1417"/>
            <end position="1433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="JAV70591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0800610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1441" mass="165438" checksum="F42DC3810002A4EE" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LDA6</accession>
    <name>A0A1Y1LDA6_PHOPY</name>
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        <recommendedName>
            <fullName evidence="3">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_11891</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01058957">
        <property type="protein sequence ID" value="JAV71603.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0795052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="interactions" value="126"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1LDA6"/>
    <dbReference type="OrthoDB" id="190201at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF14">
        <property type="entry name" value="SERINE HYDROLASE-LIKE PROTEIN DDB_G0286239"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
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        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="45"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="JAV71603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0795052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="308" mass="35293" checksum="D588FE6D9BE79B25" modified="2017-08-30" version="1">MSRLEIETNGFHSEGQMDEVFEEISIEVPWGHIVGKWWGRKDIQPVLAIHGWQDNAGTFDTLAPLLIGPKVSILCIDLPGHGFSSHYPKGQTYYIFWDGVYHVRRIVKHFKWEKFSIMGHSLGGAIGFLYASIYPDEVDKLISLDIVCPPVRDIISTMGETIDLFFKYEALKPEACPQYEYDDMIDITVDGHNNKLTRASCEILMRRGMRPTPEDKSIYRFTRDIRLKSSIMSALTLEQAYAFAVRISCNVLNIRATIHSIQLEYYESVLDKIRTNAKVEYHLVNGTHHVHLNNPERVSGIISKFLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LJI6</accession>
    <name>A0A1Y1LJI6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_12222</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01054182">
        <property type="protein sequence ID" value="JAV73803.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0795383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1LJI6"/>
    <dbReference type="InParanoid" id="A0A1Y1LJI6"/>
    <dbReference type="OrthoDB" id="2535391at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000795">
        <property type="term" value="C:synaptonemal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019789">
        <property type="term" value="F:SUMO transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007129">
        <property type="term" value="P:homologous chromosome pairing at meiosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042123">
        <property type="entry name" value="Zip3/RNF212-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22663">
        <property type="entry name" value="RING FINGER PROTEIN NARYA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22663:SF17">
        <property type="entry name" value="RING FINGER PROTEIN NARYA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14634">
        <property type="entry name" value="zf-RING_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0469">Meiosis</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="1 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="7"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="JAV73803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0795383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="245" mass="27054" checksum="DAB8EAE99ECE48D5" modified="2017-08-30" version="1">MAEFVICNKCLSTDNSNVPFYFTTCGHLQCEGCVAKSDKTKCVVCKLPTDLKPLTNLGPEMQPFFNSICDVLDQAKQVSTFQDYNKNLITQSLTDKHRLVKQKLYKCYKTLQGMKKENAMLRLVIQNMVKTAPAGSPMAGVLSPGNSDISSIFSRRPSSVAFSLPGQPTSTAWNNSSKNVSPMFNPSLEDSRSFMIPSQSSVSANVIEDSFDDRRISNSASVSQQRSSLMKYMSQLNLASKDKPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LJU8</accession>
    <name>A0A1Y1LJU8_PHOPY</name>
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        <recommendedName>
            <fullName evidence="15">Protein krueppel</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PPYR_07521</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GEZM01055208">
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        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="InParanoid" id="A0A1Y1LJU8"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="zinc finger protein 197 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012934">
        <property type="entry name" value="Znf_AD"/>
    </dbReference>
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        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379:SF121">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379">
        <property type="entry name" value="KRAB AND ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07776">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
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        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZAD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZAD" evidence="11">
        <location>
            <begin position="3"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="169"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="226"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="254"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="282"/>
            <end position="310"/>
        </location>
    </feature>
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        <location>
            <begin position="302"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="304"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="5"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="JAV73088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAB0799641.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="329" mass="38029" checksum="1151944D6A73C492" modified="2017-08-30" version="1">MENMCRTCLKVSPRLSNIFDDSSLPLKIESISSIQVSIGDNLPNKVCDMCTRNIHLLYDFRRIIIKSDLLLRQRIEQETPKEEQLQTTDITIIKNEVVANDQSNTEHRLNSTSNFKCSTCDFTCVNYFQWKEHKRTHIKSVKSICSMCGKCIRKDNMRKHIMTHTEPPVQCQICGKTCKNTESLRGHLLAHKNNKLQCTTCGNVYRHRAAYAAHLKRHLLGDKKTVECSICAKLFYDHRTLKKHIRSHTGERPYPCPYCKKGFSSSNARNTHVRQHTNEKPYACEFCPCAFPQKVSLRTHLKSKHADKLERQEEAKREETKTDDSVNGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LZ98</accession>
    <name>A0A1Y1LZ98_PHOPY</name>
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        <submittedName>
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        </submittedName>
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        <name evidence="5" type="ORF">PPYR_13008</name>
    </gene>
    <organism evidence="4">
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        <name type="synonym">Lampyris pyralis</name>
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        <lineage>
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            <taxon>Metazoa</taxon>
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            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
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                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
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                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01044907">
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        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01044906">
        <property type="protein sequence ID" value="JAV78048.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1LZ98"/>
    <dbReference type="FunCoup" id="A0A1Y1LZ98">
        <property type="interactions" value="51"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1LZ98"/>
    <dbReference type="OrthoDB" id="8251179at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Exu_RNase_H-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040941">
        <property type="entry name" value="SAM_Exu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12384">
        <property type="entry name" value="MATERNAL PROTEIN EXUPERANTIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12384:SF2">
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    </dbReference>
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    </dbReference>
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            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Exuperantia SAM-like" evidence="2">
        <location>
            <begin position="264"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="364"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="JAV78048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0793388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0803273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="412" mass="46460" checksum="1283778B7E8775F6" modified="2017-08-30" version="1">MVQTEDIVAEDNEKVLPRAPKGVPDGNYKLIGWSIDTTGRRLIDEICQIAAYSTTSQFSQHIMPFSDLNVGSRRRHNLRIINIGRYRMLKNLKTNKFVKTKSEISALTDFLTWLEANRGDAKDGVILVYHEFRKTSPAMLLEALRRYSLIERFSQVVKGFANGFNIASVQCKNTTKSFSLRVMSRMLLNKEDDFGNAIDRAQAAFEVVVHLGQAEKTDVNDTNANNNNEGHISSFISKFVNPVSAEEEEIANFKVLLERQNTFRPVFGALMKATLPERRHASHLRRLLAENNIDYAKLQSAYESSAKDGIEGILKNEVPNAKEKDLTELLEILDCFFDPEKKAIQPKPRFFANQNRNPRSRTQSNNNKENGEVNGNNNSTEGSVNTSSSETTPRTVENGIVEQSQPSETVVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2023-06-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1M0W0</accession>
    <name>A0A1Y1M0W0_PHOPY</name>
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            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">PPYR_00652</name>
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        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Hexapoda</taxon>
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            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
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            <taxon>Elateroidea</taxon>
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            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01043554">
        <property type="protein sequence ID" value="JAV79031.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1M0W0"/>
    <dbReference type="InParanoid" id="A0A1Y1M0W0"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="JAV79031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0803682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="262" mass="30069" checksum="522AD7BAC5EBDE5F" modified="2017-08-30" version="1">MCKTCQYCLESCYWHLIEKRFCYDESIALYEEPAKPIEKSTNAFDNIAFYDQVALIAGRSIVTIEPLPKKPKAITQQPKPRVRWWETEREEGENNNNAPQVQVKVLEIDDQPPKEKPAVNRLDPMLLNLGEVKLRPKSLAERRNSRSLTLNIDRRHEIPIIRQASMPKFFIDTPEVHTDPVAFREPSAVFISPLSVNHLSDPFDLKSVVQLEKDNRNVPAAPIHRQQSAYFSRLSLIKDKLKAGKLTRQGSASNLPHSIQHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1MCE7</accession>
    <name>A0A1Y1MCE7_PHOPY</name>
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        <recommendedName>
            <fullName evidence="1">AH domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">PPYR_10861</name>
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    <organism evidence="2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
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        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
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            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01040022">
        <property type="protein sequence ID" value="JAV80997.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1MCE7"/>
    <dbReference type="FunCoup" id="A0A1Y1MCE7">
        <property type="interactions" value="314"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1MCE7"/>
    <dbReference type="OrthoDB" id="2126778at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019904">
        <property type="term" value="F:protein domain specific binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051049">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="AH_dom"/>
    </dbReference>
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        <property type="entry name" value="Islet_autoAg_Ica1/Ica1-like"/>
    </dbReference>
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        <property type="entry name" value="GH23156P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10164">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06456">
        <property type="entry name" value="Arfaptin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01015">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50870">
        <property type="entry name" value="AH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AH" evidence="1">
        <location>
            <begin position="27"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="JAV80997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0796800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="397" mass="44728" checksum="950486E753F72D8B" modified="2017-08-30" version="1">MMQHQYWITKKSVQRKLGSKEDECIVSSDAELDAKLELFRSIAESCIHLQRIIDLYQERLCYLAQEENALGRYLKECGKNEKNASAGQLLAAAGKALAYTGHQRLTIRPPLLRLHHEVETFRGRAVSDTRVTVSEMEKIRTEYRAALSWMKSVSTELDPDTGCGLERFRKAQTYVKSSKVRFDRLMLACLQKVDLLAAARCNMFSHALISYQNAISTFSSKASDTLLLCSSKLKNVEPFEFSIVSELATPQDKEEKDKSTFFNADYTDKVKEEKAQEAETTSRDASEVSNLLGEDFTPSMPESKAPAMVEDKALTNLALLEMNISSEADLLGDFMPSRLMQEENFFNLPEQFDSVPNNNIPSKLKGNEKTEAQVSWLSLFKELDPLANQDLGSGDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2023-09-13" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1MEK3</accession>
    <name>A0A1Y1MEK3_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_04473</name>
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    <organism evidence="2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01033508">
        <property type="protein sequence ID" value="JAV84232.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1MEK3"/>
    <dbReference type="InParanoid" id="A0A1Y1MEK3"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036312572" evidence="1">
        <location>
            <begin position="22"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="JAV84232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0802287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="147" mass="16032" checksum="7DC985CEF962ADCA" modified="2017-08-30" version="1">MVAFLYFFVIILCFTIHGAEHKPVDTNIRSDVVVTSGFNIKNPYYTNGATDQTMPTETDSSNEPGWMRRQLKKLGNMFGSIGNGLGGFTKRITGTLDKFCELVKTIIPVVAAVCHVGQFQFCGSVADAPKELAEALSPINIDLSIPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1MRT9</accession>
    <name>A0A1Y1MRT9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Complex I-B12</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">NADH-ubiquinone oxidoreductase B12 subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PPYR_02476</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">1611_PpyrPB1</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">1611_PpyrPB1</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFB3 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01024440">
        <property type="protein sequence ID" value="JAV87788.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0805506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1MRT9"/>
    <dbReference type="FunCoup" id="A0A1Y1MRT9">
        <property type="interactions" value="603"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1MRT9"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012576">
        <property type="entry name" value="NDUFB3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15082:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15082">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE B12 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08122">
        <property type="entry name" value="NDUF_B12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="JAV87788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAB0805506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="99" mass="11492" checksum="E125DE6432356AD2" modified="2017-08-30" version="1">MGGDHHHHEIKVPDYKSYRVEDAPELLKVREKLAARGLSDPWLRNEVWRYDRRLWGTEGQRIMLTFSRGFKYGFAAFVVTILGTKLLGSGSDHHDHGHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1MU19</accession>
    <name>A0A1Y1MU19_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cleavage stimulation factor subunit 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Cleavage stimulation factor 50 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PPYR_09706</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs. May be responsible for the interaction of CSTF with other factors to form a stable complex on the pre-mRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer. The CSTF complex is composed of CSTF1 (50 kDa subunit), CSTF2 (64 kDa subunit) and CSTF3 (77 kDa subunit). Interacts (via repeats WD) directly with CSTF3. Interacts (via repeat WD6) with BARD1. Interacts with ERCC6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GEZM01021115">
        <property type="protein sequence ID" value="JAV89131.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1MU19"/>
    <dbReference type="FunCoup" id="A0A1Y1MU19">
        <property type="interactions" value="2229"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1MU19"/>
    <dbReference type="OrthoDB" id="14421at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005848">
        <property type="term" value="C:mRNA cleavage stimulating factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.960.50:FF:000001">
        <property type="entry name" value="Cleavage stimulation factor subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000064">
        <property type="entry name" value="Cleavage stimulation factor subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000089">
        <property type="entry name" value="Cleavage stimulation factor subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.960.50">
        <property type="entry name" value="Cleavage stimulation factor subunit 1, dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044633">
        <property type="entry name" value="CstF1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032028">
        <property type="entry name" value="CSTF1_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038184">
        <property type="entry name" value="CSTF1_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44133">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44133:SF2">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16699">
        <property type="entry name" value="CSTF1_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 10" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Cleavage stimulation factor subunit 1 dimerisation" evidence="11">
        <location>
            <begin position="15"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="175"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="264"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="315"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="399"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00058408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00066148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00074323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="JAV89131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAB0798713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="437" mass="48199" checksum="22014B214EFC770F" modified="2017-08-30" version="1">MKCDNMNEEDITTKNLIKSRECLYRLMISQLFYDGHQSIATTLSSAVSADPPCAPSDRLLRIMMAGLENEPDRKDRPTNVGIGNNNVGPGLDLEFETESNLPAPEPALYETAYVTSHKGNCRAGCFSGDGQLIATGSVDASIKILDVDRMLAKSAPDEMDPSRGEQQGHPVIRTLYDHMEEVTCLEFHPRELILLSGSKDLTIKLFDISKASVKKAFKTITEAEPVRCFALHPAGEHLLVGTQHPVIRLYDINTSQCFVCSIPSNQHTSSVTCMKWSNDAKVFATCSKDGSIKLWDGVSNRCINTFAKAHDGLEVCSVAFTKNGKYLLSSGKNSICKLWELTTSRCLIAYTGAGTTGKQEYEAQAVFNHTEDYVLFPDEATTSLCAWNSRNASRKTLLSLGHNGAVRLIAHSPTQAAFLTCSDDFRARFWYRRTATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1MUW5</accession>
    <name>A0A1Y1MUW5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">E2 ubiquitin-conjugating enzyme</fullName>
            <ecNumber evidence="1">2.3.2.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PPYR_12466</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="1"/>
    <dbReference type="EMBL" id="GEZM01020010">
        <property type="protein sequence ID" value="JAV89462.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0795627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1MUW5"/>
    <dbReference type="FunCoup" id="A0A1Y1MUW5">
        <property type="interactions" value="1755"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1MUW5"/>
    <dbReference type="OrthoDB" id="7851174at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23793">
        <property type="entry name" value="UBCc_UBE2E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000003">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 E3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="9">
        <location>
            <begin position="40"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="JAV89462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0795627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="186" mass="20372" checksum="BF44972DD2D604C7" modified="2017-08-30" version="1">MSTAGSSGSGRGRGGQSIGDQAKEAKESKPNPKMSKALGTSAKRIQKELAEITLDPPPNCSAGPKGENFYEWVSTILGPPGSVYEGGVFFLDIHFTPEYPFKPPKVTFRTRIYHCNINSQGVICLDILKDNWSPALTISKVLLSICSLLTDCNPADPLVGSIATQYLQNREEHDRIARLWTKRYAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1MW36</accession>
    <name>A0A1Y1MW36_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PPYR_15608</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="19 20" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">1611_PpyrPB1</strain>
            <tissue evidence="19">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">1611_PpyrPB1</strain>
            <tissue evidence="19">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the DEAD box helicase family. DDX56/DBP9 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="GEZM01020188">
        <property type="protein sequence ID" value="JAV89328.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01001976">
        <property type="protein sequence ID" value="KAB0790076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1MW36"/>
    <dbReference type="FunCoup" id="A0A1Y1MW36">
        <property type="interactions" value="1722"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1MW36"/>
    <dbReference type="OrthoDB" id="1191041at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17961">
        <property type="entry name" value="DEADc_DDX56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001046">
        <property type="entry name" value="Probable ATP-dependent RNA helicase ddx56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF21">
        <property type="entry name" value="DEAD-BOX HELICASE 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="17">
        <location>
            <begin position="10"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="41"/>
            <end position="219"/>
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            <end position="426"/>
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        </location>
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        <location>
            <begin position="508"/>
            <end position="554"/>
        </location>
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        <location>
            <begin position="10"/>
            <end position="38"/>
        </location>
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        <source>
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        </source>
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        <source>
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        </source>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="JAV89328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAB0790076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="554" mass="62968" checksum="7DEF55D03FCA48CA" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1N003</accession>
    <name>A0A1Y1N003_PHOPY</name>
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        <recommendedName>
            <fullName evidence="5">UDP-glucuronosyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.17</ecNumber>
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    </protein>
    <gene>
        <name evidence="8" type="ORF">PPYR_01057</name>
        <name evidence="9" type="ORF">PPYR_02602</name>
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    <organism evidence="7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
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                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 5">
            <text>glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:132367"/>
            <dbReference type="ChEBI" id="CHEBI:132368"/>
            <dbReference type="EC" id="2.4.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Membrane</location>
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    </comment>
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        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
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        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
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        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
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        <property type="molecule type" value="Transcribed_RNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1N003"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="UniProtKB-EC"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="1"/>
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        </location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="474"/>
            <end position="500"/>
        </location>
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        </source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="KAB0805632.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1N5E2</accession>
    <name>A0A1Y1N5E2_PHOPY</name>
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        <recommendedName>
            <fullName evidence="5">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="7" type="ORF">PPYR_01762</name>
    </gene>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GEZM01013315">
        <property type="protein sequence ID" value="JAV92668.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1N5E2"/>
    <dbReference type="InParanoid" id="A0A1Y1N5E2"/>
    <dbReference type="OrthoDB" id="295274at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14686">
        <property type="entry name" value="bZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051027">
        <property type="entry name" value="bZIP_transcription_factors"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19304">
        <property type="entry name" value="CYCLIC-AMP RESPONSE ELEMENT BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
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    <sequence length="332" mass="36990" checksum="FC6EF154260FDD85" modified="2017-08-30" version="1">MNECSDKLLSSTNEHHNNKRTLGLQLGIGGDSNSDDQTPTPTRFIRNCEEVGLFQDLQDVNPFEETFRKAATDLATHGSLHLPPVASKDESLHTPHIFPHIPQEGVKYSNSDDEFSLNDDILVIDESEIHQSTTTQSIVPQVTNSTNETVRVPGQVEGAAKKVVGKKRVVHLQKQRELNRAAQVRSRAKKKVMFHTLVEEVSLLKSQTKELAKENERLRREVVWLKTMLMYHKDCPVAKDPRIMEEVEKLRRKKAQHSVPTVLVPVQSNQSSQLTQLVALQPITAGVLLKIPNAPKPIIPKLAPLRPKGAHCTVASGVSNGTLNGIKAEKMY</sequence>
</entry>
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    <accession>A0A1Y1N5U8</accession>
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        <name type="scientific">Photinus pyralis</name>
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            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
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            <taxon>Elateroidea</taxon>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
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                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
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            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
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        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
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        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="JAV92260.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAB0797467.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="517" mass="57501" checksum="4B343231F9013914" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
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    <name>A0A1Y1N7F1_PHOPY</name>
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        <name evidence="8" type="ORF">PPYR_09366</name>
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        <name type="scientific">Photinus pyralis</name>
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        </lineage>
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    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
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            <dbReference type="PubMed" id="28004739"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
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        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
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    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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    <dbReference type="EMBL" id="GEZM01010802">
        <property type="protein sequence ID" value="JAV93823.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000006">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:heme export"/>
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        <property type="match status" value="2"/>
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        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
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        <property type="entry name" value="GH15861P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10924">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
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            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
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        </location>
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        </location>
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        <location>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1N7S2</accession>
    <name>A0A1Y1N7S2_PHOPY</name>
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    </protein>
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    <organism evidence="7">
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
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                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
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                <person name="Bessho-Uehara M."/>
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                <person name="Debat H.J."/>
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                <person name="Day J.C."/>
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    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SH3BP5 family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01007663">
        <property type="protein sequence ID" value="JAV95016.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0794875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1NG07"/>
    <dbReference type="FunCoup" id="A0A1Y1NG07">
        <property type="interactions" value="1368"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1NG07"/>
    <dbReference type="OrthoDB" id="446789at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004860">
        <property type="term" value="F:protein kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007940">
        <property type="entry name" value="SH3BP5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19423">
        <property type="entry name" value="SH3 DOMAIN-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19423:SF1">
        <property type="entry name" value="SH3 DOMAIN-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05276">
        <property type="entry name" value="SH3BP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="12"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="127"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="JAV95016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0794875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="383" mass="43940" checksum="4644D91348F9D071" modified="2017-08-30" version="1">MEEGENDLDPRIQIELEKLNTATDEINKLEIELDEANTTFRMILNESTRRLKVLSKKLGGCIDRVRPYFTALEVAKKAQHECQKAAVIFQRASEIHAAAKETVALAEQRFMSNKHEWQFDNAWQEMLNHATIKVMEAENEKAESGREHQKRAMLFNAAEQKVQQLEDRLRRHIIKARPYFDEKALCQEQLGTQKERIESLQEQINKTKYSYSEALKKLEQISNEIHMKRKSLGIAECENELLTRPREPGVGAELCESSGQIDFAAKLQSLDFNSELDKCEVHSMGSISGTASSAVSEKDEDEDLDDEYLDELKLKVKELAIRPIDGGEGKSTDEMWESELKHTVDKLDHMLLMQECAKELNSYEDGKLVTDNFKTDQDLTQTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N3ZZP4</accession>
    <name>A0A5N3ZZP4_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_15055</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01001134">
        <property type="protein sequence ID" value="KAB0790544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N3ZZP4"/>
    <dbReference type="InParanoid" id="A0A5N3ZZP4"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33480">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33480:SF1">
        <property type="entry name" value="TYR RECOMBINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="825"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0790544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="825" mass="94607" checksum="C456E37C435E77F1" modified="2020-02-26" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N3ZZS3</accession>
    <name>A0A5N3ZZS3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7869 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_15021</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01001107">
        <property type="protein sequence ID" value="KAB0790571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N3ZZS3"/>
    <dbReference type="InParanoid" id="A0A5N3ZZS3"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057191">
        <property type="entry name" value="DUF7869"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10773:SF19">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10773">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25273">
        <property type="entry name" value="DUF7869"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7869" evidence="1">
        <location>
            <begin position="240"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0790571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="479" mass="55921" checksum="76038C8B92F3BFA0" modified="2020-02-26" version="1" fragment="single">VYISRQKVQICQKFVMAVYNVCQRRLNTICKKLQAGEEIIKEKRGGDRRAFKFVDKLDAVKSFISQLQGKESHYGRQKSRRIYISSEYNISILWQLYNKNSPEGLKVNYKYFSRVFSKYFNIGFGSPATDVCSYCVRTQTKISMSQSSSEKQKISTELKVHKFRATQFHKLMKTEVPNTVSYCFDLQQVQVLPKVPIQEAFYAQQLSIYFFCVTKLNCQEPIFYTWMEHQAGRGATETSSAIIDFLKRTEFPEDATKIRFFADGCGGQNKNSHVIHALMFWLHTSGEKIKEIEIIFPIRGHSYLPADRIFGRIEKILRSHSLIKTPDAYWELYTKVGEVRKLGSDWNLLDVKNMLQWLKKVNGISSCRRFFIKKNVSANNILVKSEVLYRTDTNKFQSLLKPRTRFDQVVVPWLPLGHQIKKKKIDSLKKLLESLSGEKWNNDPELAWLVPIFEEQREDGEIEANEECECNDMEEVNFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A067</accession>
    <name>A0A5N4A067_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_14894</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000938">
        <property type="protein sequence ID" value="KAB0790668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A067"/>
    <dbReference type="InParanoid" id="A0A5N4A067"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33053">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33053:SF24">
        <property type="entry name" value="TRANSPOSASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0790668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="705" mass="80257" checksum="A59628C677442E4D" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A114</accession>
    <name>A0A5N4A114_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_02786</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0790986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A114"/>
    <dbReference type="InParanoid" id="A0A5N4A114"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902936">
        <property type="term" value="F:phosphatidylinositol bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1200">
        <property type="entry name" value="Alpha-tocopherol transfer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.20">
        <property type="entry name" value="N-terminal domain of phosphatidylinositol transfer protein sec14p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174">
        <property type="entry name" value="ALPHA-TOCOPHEROL TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174:SF224">
        <property type="entry name" value="RETINOL-BINDING PROTEIN PINTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00180">
        <property type="entry name" value="CRETINALDHBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="80"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0790986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="280" mass="33267" checksum="00A833596F9147AF" modified="2020-02-26" version="1">MLRRRVSRAFRKKSCNVELECLKEWMENNPDLQCKIDDHWLLVFLSSCKYNVERTKAKIEMFYIVRYAMPEIFTHRDPRLPRVQQILNLGLFVPLVNPTAEANYDTVIVRMTFFDPEKIPIQLIMKVDLMIIDVLLTDAATQFKDIEFLIDLKDFSNNYHEQLSPNQLKRLLHYFEDSYPVKVRAVHFINPPPFAMPFLNLFTLFVSEKNRNKIRVYCENEEFDVTQIFPRDALPVELNGTNSSLEEMRAQWKAKVEDYRDWFLEGENQPTPDSNAFWIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A160</accession>
    <name>A0A5N4A160_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PPYR_02857</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">1611_PpyrPB1</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A160"/>
    <dbReference type="FunCoup" id="A0A5N4A160">
        <property type="interactions" value="17"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A160"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11056">
        <property type="entry name" value="CYP6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000042">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050476">
        <property type="entry name" value="Insect_CytP450_Detox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292:SF100">
        <property type="entry name" value="CYTOCHROME P450 6A16, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0492">Microsome</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="464"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAB0791057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="521" mass="59634" checksum="FEF839FA9727266C" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A1B0</accession>
    <name>A0A5N4A1B0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PPYR_02914</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A1B0"/>
    <dbReference type="FunCoup" id="A0A5N4A1B0">
        <property type="interactions" value="57"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A1B0"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000249">
        <property type="entry name" value="facilitated trehalose transporter Tret1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050549">
        <property type="entry name" value="MFS_Trehalose_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021:SF89">
        <property type="entry name" value="FI02132P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="265"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="300"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="330"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="362"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="397"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="427"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="20"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0791114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="477" mass="52706" checksum="37AAE3A993ABB512" modified="2020-02-26" version="1">MDIQKQRNVTQRSTFVQILLGLIVNFSSLSPSMSLGFSAVALPYLLDASNPHRLTEDEASWFASIASVAAPLGCFLSGPISDRFGRKPAIQSVNVFCLLGWTAITFAYYSPGHQYRLLLVGRFFTGLSTGLSSMPATVYMAEISTAKLRGMLITWNALCFSLGVVVIYILGWTMTSNWGMIAALSGAFPCANVVMVMIYMVESPSWLITKNRHEDAKASLLRLFNSKSHPLEIREEIETLTCDTRRTKADHQLRYFAEPAIYRPFILMSAFFVFQQVSGTFVIVFYAIDIVNEAQISIDPYLAIVIIAATRSVASVIVSVASRRLGRRPLSITSGVGMTLCMVMLSAYVACVQRKIIDHHDWLPLTLLMAYFFTATLGFLTIPFAMSAEVFPSTIRGLATGMVSSMGYICCFVMVKIYPDMLSVMGIYPLFIFYAAMSAIGTIFVMLCLPETKGRTLSEIESYFSVQKPGTELVALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A1W9</accession>
    <name>A0A5N4A1W9_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_03096</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A1W9"/>
    <dbReference type="FunCoup" id="A0A5N4A1W9">
        <property type="interactions" value="42"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A1W9"/>
    <dbReference type="OrthoDB" id="6358661at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062129">
        <property type="term" value="C:chitin-based extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:structural constituent of chitin-based larval cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050468">
        <property type="entry name" value="Cuticle_Struct_Prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380">
        <property type="entry name" value="CUTICLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380:SF173">
        <property type="entry name" value="CUTICULAR PROTEIN 47EF, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024414785" evidence="3">
        <location>
            <begin position="18"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0791296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="173" mass="19074" checksum="34BEBEC544E775EB" modified="2020-02-26" version="1">MEIKFVQCLILLPFVWAVPPEPELDLPPRPYAFGYAAGRFAGHIDRTHSEISTGDGVVKGTYSYVDPRHQIRTVDYIADKQGFRAVLNHSPLPLPVDSPVVAAAKERHLQQYNAIAHSHQAPPGYLVVPADSAAVHHAKVKHLSLYEQIAAEHARIAHERGAFEAETADPHVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A252</accession>
    <name>A0A5N4A252_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF243 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_03148</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A252"/>
    <dbReference type="FunCoup" id="A0A5N4A252">
        <property type="interactions" value="45"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A252"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062129">
        <property type="term" value="C:chitin-based extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008010">
        <property type="term" value="F:structural constituent of chitin-based larval cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040003">
        <property type="term" value="P:chitin-based cuticle development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004145">
        <property type="entry name" value="DUF243"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31927">
        <property type="entry name" value="FI07246P-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31927:SF13">
        <property type="entry name" value="TWEEDLEBETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03103">
        <property type="entry name" value="DUF243"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00690">
        <property type="entry name" value="DM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF243" evidence="2">
        <location>
            <begin position="51"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0791348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="178" mass="19404" checksum="A762CF9AFEBE8908" modified="2020-02-26" version="1">MKQFNCYAILFVVAVQCRPSPEAGFNGYSPSAPSNGYGPPAPQYGAPPQQPIVHKHVYVHVPPPENEYPAPRKTIPVAPAQKHYKIIFIKAPTPPTPTAPVIPVQPQNEEKTLVYVLVKKPEPEPEIVIPTPAPTQPSKPEVYFIRYKTQKQESGYPDSGVPQSYGPPSAPSGEYGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-09-13" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A3K5</accession>
    <name>A0A5N4A3K5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein sleepless</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_03696</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A3K5"/>
    <dbReference type="InParanoid" id="A0A5N4A3K5"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024441478" description="Protein sleepless" evidence="1">
        <location>
            <begin position="21"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0791896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="113" mass="12747" checksum="05873E72ABEDCB0D" modified="2020-02-26" version="1">MYFKLVLVSVGLICVGVASGGSTRYCHDCVGRTDTSPKDFSNCRNYVNVTKNDDCSSQAYCISKLGTETRNKVTVEIAVRMCSDRNCEWQRKYNAGEKYCSECQSDYCNNDKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A3S0</accession>
    <name>A0A5N4A3S0_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_13912</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0791951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A3S0"/>
    <dbReference type="InParanoid" id="A0A5N4A3S0"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23992">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.20">
        <property type="entry name" value="Pheromone/general odorant binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006170">
        <property type="entry name" value="PBP/GOBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036728">
        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01395">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024405252" evidence="1">
        <location>
            <begin position="17"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0791951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="140" mass="16221" checksum="704A664B604FC393" modified="2020-02-26" version="1">MLRLSLLFTIYCSIDASFYHSEKPTLDALELWHCTTDAINDTCVQSSGADRDQVQLLWSDLMYSETRNLKCYLACMYKNVDFMNSHGELVGPTIVQENENLITMEEFELCDDVAKRIADQCEKTFEFSYCLTHTNHTNHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A3Z4</accession>
    <name>A0A5N4A3Z4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phospholipase A2</fullName>
            <ecNumber evidence="3">3.1.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Phosphatidylcholine 2-acylhydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PPYR_13997</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">1611_PpyrPB1</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.4" evidence="3"/>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A3Z4"/>
    <dbReference type="FunCoup" id="A0A5N4A3Z4">
        <property type="interactions" value="73"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A3Z4"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050482">
        <property type="term" value="P:arachidonate secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04704">
        <property type="entry name" value="PLA2_bee_venom_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.90.10:FF:000002">
        <property type="entry name" value="Phospholipase A2 group III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.90.10">
        <property type="entry name" value="Phospholipase A2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016090">
        <property type="entry name" value="PLA2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033113">
        <property type="entry name" value="PLA2_histidine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036444">
        <property type="entry name" value="PLipase_A2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12253">
        <property type="entry name" value="RH14732P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05826">
        <property type="entry name" value="Phospholip_A2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48619">
        <property type="entry name" value="Phospholipase A2, PLA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00118">
        <property type="entry name" value="PA2_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024377370" description="Phospholipase A2" evidence="13">
        <location>
            <begin position="19"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipase A2-like central" evidence="14">
        <location>
            <begin position="48"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF05826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAB0792036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="182" mass="20862" checksum="576440F468A313AD" modified="2020-02-26" version="1">MKAITAVIISMLIANVWASTVTYLDSTTATPETKENDDDDPWYMWILIYPGTKWCGAGNISDTENDLGSAHETDGCCRAHDYCDDTITANATAHNLTNNAPFTLSNCKCDDQFYACLKKADTSNSRRVGRIFFNYLGTKCFREDYPVVKCTKSIYFPRYKCLEYEYDTTKDKKYQWFNVPQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A4U4</accession>
    <name>A0A5N4A4U4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">26S proteasome complex subunit SEM1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_14280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the DSS1/SEM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A4U4"/>
    <dbReference type="FunCoup" id="A0A5N4A4U4">
        <property type="interactions" value="98"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A4U4"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007834">
        <property type="entry name" value="DSS1_SEM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16771">
        <property type="entry name" value="26 PROTEASOME COMPLEX SUBUNIT DSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16771:SF0">
        <property type="entry name" value="26S PROTEASOME COMPLEX SUBUNIT SEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05160">
        <property type="entry name" value="DSS1_SEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01385">
        <property type="entry name" value="DSS1_SEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU369057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0792321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="68" mass="8157" checksum="6D5F8D071AF8D852" modified="2020-02-26" version="1">MSEKPKLDLGLLEEDDEFEEFPVEDWTGKDKDEQDISVWEDNWEDDNIEDDFNKQLRAQLEKQKPKAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A580</accession>
    <name>A0A5N4A580_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DDHD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PPYR_14439</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PtdIns transfer protein family. PI transfer class IIA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A580"/>
    <dbReference type="FunCoup" id="A0A5N4A580">
        <property type="interactions" value="594"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A580"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031210">
        <property type="term" value="F:phosphatidylcholine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008525">
        <property type="term" value="F:phosphatidylcholine transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008526">
        <property type="term" value="F:phosphatidylinositol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08889">
        <property type="entry name" value="SRPBCC_PITPNM1-2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000173">
        <property type="entry name" value="Membrane-associated phosphatidylinositol transfer protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.530.20:FF:000001">
        <property type="entry name" value="Phosphatidylinositol transfer protein membrane associated 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004177">
        <property type="entry name" value="DDHD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031315">
        <property type="entry name" value="LNS2/PITP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001666">
        <property type="entry name" value="PI_transfer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055261">
        <property type="entry name" value="PI_transfer_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10658">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL TRANSFER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10658:SF81">
        <property type="entry name" value="PROTEIN RETINAL DEGENERATION B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02862">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02121">
        <property type="entry name" value="IP_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24694">
        <property type="entry name" value="LNS2_PITM1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24695">
        <property type="entry name" value="PITM1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00391">
        <property type="entry name" value="PITRANSFER"/>
    </dbReference>
    <dbReference type="SMART" id="SM01127">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00775">
        <property type="entry name" value="LNS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51043">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDHD" evidence="7">
        <location>
            <begin position="689"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="316"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="446"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="665"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1192"/>
            <end position="1211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="316"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1195"/>
            <end position="1204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0792480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1250" mass="139003" checksum="179011DB05C62473" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A5G9</accession>
    <name>A0A5N4A5G9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">BBSome complex member BBS5 PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PPYR_14460</name>
        <name evidence="12" type="ORF">PPYR_14468</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Centrosome</location>
            <location evidence="2">Centriolar satellite</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the BBS5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A5G9"/>
    <dbReference type="FunCoup" id="A0A5N4A5G9">
        <property type="interactions" value="85"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A5G9"/>
    <dbReference type="OrthoDB" id="10261999at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034464">
        <property type="term" value="C:BBSome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034451">
        <property type="term" value="C:centriolar satellite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060170">
        <property type="term" value="C:ciliary membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006606">
        <property type="entry name" value="BBL5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030804">
        <property type="entry name" value="BBS5/fem-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014003">
        <property type="entry name" value="BBS5_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21351:SF0">
        <property type="entry name" value="BARDET-BIEDL SYNDROME 5 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21351">
        <property type="entry name" value="BARDET-BIEDL SYNDROME PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07289">
        <property type="entry name" value="BBL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010072">
        <property type="entry name" value="DUF1448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00683">
        <property type="entry name" value="DM16"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BBSome complex member BBS5 PH" evidence="10">
        <location>
            <begin position="25"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="BBSome complex member BBS5 PH" evidence="10">
        <location>
            <begin position="155"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0792501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAB0792509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="339" mass="38416" checksum="E79131801D7CFA36" modified="2020-02-26" version="1">MGLGWEDKEVHFDLSFSDMRLTIGEKVIDRLDNIEDTKGNGGDRGKLIITNLRILWHSVSNPRINLSIGYNSITTLNTKIVNSKLRGTTQALYLMTVCHGSRYEFIFTNLVPGSMRHFTSVTGVHKAYTTSKAYRELKLRGAVVHNKRLRILPLEQVCNVLHGVWNLSSDQGSLGTFYITNVRLVWFADMNEAFNISLPYLQINSIRIRDSKFGRALVITCNQTSGGYILGFRIDPEDQLNLIFKELSSLFTVYASNPIYGIEYEWSSKEDEKENAILTEDVEEVDDPRNEISNVLITYSANGDTGKDRPIVYSNELGLAIESLKEGYTIQKLWEVVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A5S1</accession>
    <name>A0A5N4A5S1_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_14611</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UXT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A5S1"/>
    <dbReference type="FunCoup" id="A0A5N4A5S1">
        <property type="interactions" value="342"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A5S1"/>
    <dbReference type="OrthoDB" id="433124at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23158">
        <property type="entry name" value="Prefoldin_UXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004127">
        <property type="entry name" value="Prefoldin_subunit_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003994">
        <property type="entry name" value="UXT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02996">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01502">
        <property type="entry name" value="UXTPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0792652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="137" mass="16133" checksum="EF5E9EBD9E1BD5A1" modified="2020-02-26" version="1">MSVAEKLKSYENFIEEKLKNDLKELETALTKKSDDFKLWQELKNSLVHLKEAKDDELNVTFEMGLGVFIGARVEEREKVIVNIGCDCYLEMYYDEAIKYADIRMKYLTKEIEFFRQQAVNVKAHIKLVLLAMNELKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A6S0</accession>
    <name>A0A5N4A6S0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_12650</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A6S0"/>
    <dbReference type="InParanoid" id="A0A5N4A6S0"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF85">
        <property type="entry name" value="GH03217P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="8">
        <location>
            <begin position="165"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0793030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="319" mass="36485" checksum="5EBA25926EADC2E4" modified="2020-02-26" version="1">MELAEGLVMAISLAKDLFFDDSYEESANKVLPKVEGFAEDIVPRFSGRQFQQHFRITVTTFEDLIIKISAIHVSEIRVGHPEMAIDKQLLITIWSLSNLESFRSVADRFGISKSTCWDVLYRTCKMLLQANERYKIITWPNAARSLIISEHFRQLNGFPGIIGAIDGTHIRILKPKDNPNSYCNRKHYHSVLLQGVCDHQKLFTDVYAGEPGSIHDLRLFRKSDLCQRITTGEVTFPNDTHLVGDLAYSLSRYLIVGFKNIGVLTARQKNFNYKLSQCRVVMENAFGYLKGRFRRLKSLETVRLDLISLLIVSGCILHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A872</accession>
    <name>A0A5N4A872_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_13143</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A872"/>
    <dbReference type="OrthoDB" id="6766761at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="412"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="511"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="719"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="889"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1033"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1253"/>
            <end position="1289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1343"/>
            <end position="1397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="527"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="724"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="752"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="894"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1068"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1279"/>
            <end position="1288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1351"/>
            <end position="1360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1373"/>
            <end position="1388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0793523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1495" mass="166110" checksum="EC3682FDFAA3DF65" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A8E5</accession>
    <name>A0A5N4A8E5_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PPYR_13213</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PBP/GOBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A8E5"/>
    <dbReference type="InParanoid" id="A0A5N4A8E5"/>
    <dbReference type="OrthoDB" id="6601693at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007608">
        <property type="term" value="P:sensory perception of smell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23992">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.20">
        <property type="entry name" value="Pheromone/general odorant binding protein domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006170">
        <property type="entry name" value="PBP/GOBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036728">
        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11857:SF43">
        <property type="entry name" value="GEO07291P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11857">
        <property type="entry name" value="ODORANT BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01395">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00708">
        <property type="entry name" value="PhBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024318922" evidence="5">
        <location>
            <begin position="19"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0793593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="232" mass="26399" checksum="73ADD31F816F3997" modified="2020-02-26" version="1">MKSIAVILCICAFSGVYASKEWKKTKEECVKESGVEKDLLKYTWKSKNVTRDDKLIAFFKCVMVKQGSLTEPCNINLTYVKNVCEKMNTTNCSYVDTCEQKKGADCEETVYLVSQCIVPNLMVNGIKNVFEDCKNKTKADKELIKKMRKEGVISDDPEFKKYLVCVAEGFNAFDDNGNISLQHLKKMCSMKKIEDCSFIEECEKKKGDSKEETAYLALSCAYPKLFSQTKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A8V0</accession>
    <name>A0A5N4A8V0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleotide-diphospho-sugar transferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_13298</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A8V0"/>
    <dbReference type="InParanoid" id="A0A5N4A8V0"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006688">
        <property type="term" value="P:glycosphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051981">
        <property type="entry name" value="Glycosyltransf_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12042:SF21">
        <property type="entry name" value="ALPHA1,4-GALACTOSYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12042">
        <property type="entry name" value="LACTOSYLCERAMIDE 4-ALPHA-GALACTOSYLTRANSFERASE ALPHA- 1,4-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0793678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="300" mass="33543" checksum="F1CAD71D2C64BD81" modified="2020-02-26" version="1">MITMSAITRRKVLFTVLLLILILSLSYVIFNANLSQRDPLGQKGSRPLSPEEIAFINKLLVSDSDETIPLKNLTRDTYNRSAIFFVRDTSSEEFELSCAVESASLRNPTFNVIVLSSDTEINSSDRLVRILQSYENVKMFHVDFGSLTNNNVSTSDVDTRLALLWSHGAIYLNHDIISLKPLRDLPDNFLVNLEDGRISFDAIGWRNRNGTEPELPANGTLPVNRLCVEVQGSLALEQRCGEFKILSFQNFYANTLNGSLVNSTAASYAVKVDGHNRVLLAKLAEKYCPTTFQEMKAKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A922</accession>
    <name>A0A5N4A922_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Aminopeptidase</fullName>
            <ecNumber evidence="20">3.4.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">PPYR_13409</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">1611_PpyrPB1</strain>
            <tissue evidence="25">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="18 20">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="18 20">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 20">Belongs to the peptidase M1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-" evidence="20"/>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A922"/>
    <dbReference type="InParanoid" id="A0A5N4A922"/>
    <dbReference type="OrthoDB" id="6665005at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09601">
        <property type="entry name" value="M1_APN-Q_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000013">
        <property type="entry name" value="Aminopeptidase N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1730:FF:000001">
        <property type="entry name" value="Leucyl-cystinyl aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034016">
        <property type="entry name" value="M1_APN-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF290">
        <property type="entry name" value="AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 20" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="9 20" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 18 20" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13 20" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6 20" id="KW-0645">Protease</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="21" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10 18 20" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="21">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024400406" description="Aminopeptidase" evidence="21">
        <location>
            <begin position="19"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="24">
        <location>
            <begin position="28"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="22">
        <location>
            <begin position="251"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1-like C-terminal" evidence="23">
        <location>
            <begin position="550"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="17">
        <location>
            <position position="324"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="346"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="19">
        <location>
            <position position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU364040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="KAB0793789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="721" mass="83870" checksum="8E06B8DB75317775" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-06-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A980</accession>
    <name>A0A5N4A980_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_13469</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A980"/>
    <dbReference type="InParanoid" id="A0A5N4A980"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.20">
        <property type="entry name" value="Pheromone/general odorant binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006170">
        <property type="entry name" value="PBP/GOBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036728">
        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01395">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024272457" evidence="1">
        <location>
            <begin position="20"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0793849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="142" mass="16018" checksum="245ADD5B33E18E3D" modified="2020-02-26" version="1">MNKSLICYTLSLCLVKALCVEIPDAMIDETTATCMKEVGVDKQALLKTIDENMLIVNKDEDTVKMLECQIGKRHFYDASGNFDKDNTIKSLAEGLVAFDKDEGERQALAIRIFDECTNSTIENQVDRLIEFHNCAMPIILQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A9T9</accession>
    <name>A0A5N4A9T9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FMP27/BLTP2/Hobbit GFWDK motif-containing RBG unit domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_13710</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0794090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A5N4A9T9">
        <property type="interactions" value="1577"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A9T9"/>
    <dbReference type="OrthoDB" id="1562405at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019441">
        <property type="entry name" value="FMP27/BLTP2/Hobbit_GFWDK_RBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045167">
        <property type="entry name" value="Hobbit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15678">
        <property type="entry name" value="ANTIGEN MLAA-22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15678:SF6">
        <property type="entry name" value="BRIDGE-LIKE LIPID TRANSFER PROTEIN FAMILY MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10344">
        <property type="entry name" value="Hobbit"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01214">
        <property type="entry name" value="Fmp27_GFWDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMP27/BLTP2/Hobbit GFWDK motif-containing RBG unit" evidence="3">
        <location>
            <begin position="1003"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1466"/>
            <end position="1516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2032"/>
            <end position="2055"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1804"/>
            <end position="1865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1491"/>
            <end position="1506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2032"/>
            <end position="2045"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0794090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="2196" mass="252018" checksum="8AD8D7DCCC5446A5" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AB77</accession>
    <name>A0A5N4AB77_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA (guanine(9)-N(1))-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.221</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_11425</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>guanosine(9) in tRNA + S-adenosyl-L-methionine = N(1)-methylguanosine(9) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43156"/>
            <dbReference type="Rhea" id="RHEA-COMP:10367"/>
            <dbReference type="Rhea" id="RHEA-COMP:10368"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="EC" id="2.1.1.221"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.221" evidence="1"/>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0794586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AB77"/>
    <dbReference type="FunCoup" id="A0A5N4AB77">
        <property type="interactions" value="1786"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AB77"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052905">
        <property type="term" value="F:tRNA (guanosine(9)-N1)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002939">
        <property type="term" value="P:tRNA N1-guanine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18101">
        <property type="entry name" value="Trm10euk_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1280.30:FF:000001">
        <property type="entry name" value="tRNA methyltransferase 10 homolog A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028564">
        <property type="entry name" value="MT_TRM10-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038459">
        <property type="entry name" value="MT_TRM10-typ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019174">
        <property type="entry name" value="NADH_DH_b-subcmplx_su6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007356">
        <property type="entry name" value="tRNA_m1G_MeTrfase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13563">
        <property type="entry name" value="TRNA (GUANINE-9-) METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13563:SF13">
        <property type="entry name" value="TRNA METHYLTRANSFERASE 10 HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09782">
        <property type="entry name" value="NDUF_B6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51675">
        <property type="entry name" value="SAM_MT_TRM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="SAM-dependent MTase TRM10-type" evidence="8">
        <location>
            <begin position="231"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="137"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="141"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0794586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="436" mass="50492" checksum="7BF9362108326D99" modified="2020-02-26" version="1">MYKRETGGARPMAIAGRFVRERERLIGMTEAERAWRKQWMQDQILSPNEPRHVPEMYKFRFNIFRRAYKAPLNYLENMLEPVIGKRAHTLRFFTGKIFLLYLAGIGVLYNLKYNQNDWTRLGGFRILENRPAVLPGDSSFPKLSTKSNPSEYGSREGKLEESPSNVNDENVAQEELFNGVPISKLTKTQMKKYKRMLQWQSVKKLKRAKEKLKTRSKKIEAKMLNIDIGPSRKQLKNAKMANSSCKIGVVIDLSFDELMINKDMGKVIKQILRVYTENRRASAPMQLHLTSFIGRCKEEMAKHNGHENWDMHFHESSYLDVFPKDKLVYLSSESDNVITELEQEKVYIIGGLVDHNSHKGVCHQKAVNEGIAHGQLPIGEYFHSVSRKVFTINQVFEILLRVSEGKTFKEAFEMILPKRINMQPTLDNSEDDSNNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ABY8</accession>
    <name>A0A5N4ABY8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Lipase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PPYR_11661</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0794822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ABY8"/>
    <dbReference type="InParanoid" id="A0A5N4ABY8"/>
    <dbReference type="OrthoDB" id="270009at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013818">
        <property type="entry name" value="Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000734">
        <property type="entry name" value="TAG_lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610:SF186">
        <property type="entry name" value="FI22312P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00151">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00821">
        <property type="entry name" value="TAGLIPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Lipase" evidence="5">
        <location>
            <begin position="55"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0794822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="521" mass="57502" checksum="BC4B1A6B967B9613" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ADN1</accession>
    <name>A0A5N4ADN1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PPYR_12263</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0795424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ADN1"/>
    <dbReference type="InParanoid" id="A0A5N4ADN1"/>
    <dbReference type="OrthoDB" id="5957871at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004989">
        <property type="term" value="F:octopamine receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071880">
        <property type="term" value="P:adenylate cyclase-activating adrenergic receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15066">
        <property type="entry name" value="7tmA_DmOct-betaAR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248:SF66">
        <property type="entry name" value="OCTOPAMINE RECEPTOR BETA-3R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="52"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="173"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="364"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="406"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="72"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAB0795424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="455" mass="51461" checksum="DDA60FD8FF2C8D5A" modified="2020-02-26" version="1">MLVNAMASFSTTLTASTATIPLVINGLHNSSQIHNHSNATSIENPHPDWTDLLILIVKGFIFVTIILSAVLGNALVIISVHRHRKLRVITNYYVVSLAMADMLVALCAMTFNASVELTDGKWVFGYYMCDVWNSFDVYFSTASILHLCCISVDRYYAIVRPLEYPITMTSKTVSFMLACCWVLPALMSFTPIFLGWYTTAKHEQFRLNNPHVCIFVVNKYYAIISSSISFWIPGVVMVTMYCRIYKEAIRQRKALSRTSSNIILNSIHQHRTSTYTHRYGEHYLHPSDGDVNVGQINGRRSTSSGSSSYGTNTTGYNTAYNSRDNSKAATELNMNGVEITDEENVNSTSTLRQQSKSWRAEHKAARTLGIIMGAFMLCWLPFFLWYVTSTVCGEVDCPTPDIVVGMLFWIGYFNSALNPLIYAYFNRDFREAFKDTLLCTLPCCFGCWKNPPRYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ADW8</accession>
    <name>A0A5N4ADW8_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_12328</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0795489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ADW8"/>
    <dbReference type="InParanoid" id="A0A5N4ADW8"/>
    <dbReference type="OrthoDB" id="6778555at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0795489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="438" mass="48608" checksum="EAF58FF9656208D2" modified="2020-02-26" version="1">MSQKVVTRSKKQSEDEANGEFKTPDNCKTKEEGTKSMKSKNETAKSEGEDGKKGAVKDSDQLNGDSSESTATKRSIHKRSRSNTPSIKNDNAKDEEDPKENTEEKEIKKDNDTSPAEAGKESDIILKDVVINIQTLQTEKYEPKNSRPSSPSTSVEMDPLILEKEDEEPIPELQFDENDIEVESEGSNSRCKTRRSHSRNVSTPKTPKIADQEAEELEIVDLSCDSRGGSVTPKKMASSNDPNIININLQPPEETIDLNDTSDTYSSVSTDNLSTKAVVGNDATRNFDFTGQDSSIFDTTTNSTFSNRSYADTVKSLSGRRGIHSAACDNYRKYVLKNTVDGKGDIYSDYESVQKITMGMKRKSRSFSPTPSKRVKSDSPGLFSYLSSPITNFRQTFKKSSTPQLVMVEKCDFDTDGDFDKIKLENGMGDGKKRCNIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AE20</accession>
    <name>A0A5N4AE20_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_12409</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NIPA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0795570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AE20"/>
    <dbReference type="FunCoup" id="A0A5N4AE20">
        <property type="interactions" value="836"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AE20"/>
    <dbReference type="OrthoDB" id="6428174at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570:SF92">
        <property type="entry name" value="SPICHTHYIN, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0795570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="321" mass="35876" checksum="B461170E5277533D" modified="2020-02-26" version="1">MEILQVVDRFWLGFGIALFANIVIAISNTVRKKAVIRREYVPLENEDKYIHYKDWVLWVSVVLMLIAQAINFIAFSLAPAFLIAATGVIGIFLTAIMWKIFYGEIFNYVGFAGLIFSILGLAMMVLNYPKREITLTVSGLAALMDQTGLIYYVIAVVILYLLTACYIVPHFGTKCVSVYVIFSLVTYSFVGSVAIIFCKCAGYSIKYLIVTGNQEEANILYMLLFLLVSIVAVGIQEIYMAKFTNSFTSASTVKAIFFILRTALVAVFSDLLFSEWSQVRDLKIVGTSIGFVLISIGALLHPLFSDYSFDDAVIGDKFRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AEU7</accession>
    <name>A0A5N4AEU7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_09895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0795834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AEU7"/>
    <dbReference type="InParanoid" id="A0A5N4AEU7"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000230">
        <property type="entry name" value="Down syndrome cell adhesion molecule, isoform D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="12"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0795834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="107" mass="11520" checksum="2C6FDF70C63A1228" modified="2020-02-26" version="1" fragment="single">LSTGFDLHLRGPTFVMEPPTRLEFSNSSGGWLDCSASGSPQPSIDWLSVDGTSVGDVSGIRRVLRNGTLVLLPFAAAAYRQDIHSTVYRCVASNGVGRIISRDVQVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AFS6</accession>
    <name>A0A5N4AFS6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Trimethylguanosine synthase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Cap-specific guanine-N(2) methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Nuclear receptor coactivator 6-interacting protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">PRIP-interacting protein with methyltransferase motif</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">PPYR_10207</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">1611_PpyrPB1</strain>
            <tissue evidence="24">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m(7)G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs). Plays a role in transcriptional regulation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78479"/>
            <dbReference type="Rhea" id="RHEA-COMP:19087"/>
            <dbReference type="Rhea" id="RHEA-COMP:19089"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:167623"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:78480"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78507"/>
            <dbReference type="Rhea" id="RHEA-COMP:19088"/>
            <dbReference type="Rhea" id="RHEA-COMP:19090"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:167623"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:78508"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78471"/>
            <dbReference type="Rhea" id="RHEA-COMP:19085"/>
            <dbReference type="Rhea" id="RHEA-COMP:19087"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:78472"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78475"/>
            <dbReference type="Rhea" id="RHEA-COMP:19086"/>
            <dbReference type="Rhea" id="RHEA-COMP:19088"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:78476"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="20">May form homooligomers. Interacts with CREBBP/CBP, EED/WAIT1, EP300/P300, NCOA6/PRIP, PPARBP/PBP and SMN.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Cajal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the methyltransferase superfamily. Trimethylguanosine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AFS6"/>
    <dbReference type="FunCoup" id="A0A5N4AFS6">
        <property type="interactions" value="637"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AFS6"/>
    <dbReference type="OrthoDB" id="194443at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015030">
        <property type="term" value="C:Cajal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071164">
        <property type="term" value="F:RNA cap trimethylguanosine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000066">
        <property type="entry name" value="Trimethylguanosine synthase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019012">
        <property type="entry name" value="RNA_cap_Gua-N2-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14741">
        <property type="entry name" value="S-ADENOSYLMETHIONINE-DEPENDENT METHYLTRANSFERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14741:SF32">
        <property type="entry name" value="TRIMETHYLGUANOSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09445">
        <property type="entry name" value="Methyltransf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="234"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="437"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="234"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00057179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00064494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00079339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00081504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KAB0796146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="696" mass="79618" checksum="FD13B8EAE5048053" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AG71</accession>
    <name>A0A5N4AG71_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Poly [ADP-ribose] polymerase</fullName>
            <shortName evidence="1">PARP</shortName>
            <ecNumber evidence="1">2.4.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_10411</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.-" evidence="1"/>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AG71"/>
    <dbReference type="InParanoid" id="A0A5N4AG71"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ poly-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990404">
        <property type="term" value="F:NAD+-protein mono-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051712">
        <property type="entry name" value="ARTD-AVP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012317">
        <property type="entry name" value="Poly(ADP-ribose)pol_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45740">
        <property type="entry name" value="POLY [ADP-RIBOSE] POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45740:SF2">
        <property type="entry name" value="POLY [ADP-RIBOSE] POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00644">
        <property type="entry name" value="PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51059">
        <property type="entry name" value="PARP_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="1" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PARP catalytic" evidence="2">
        <location>
            <begin position="9"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU362114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0796350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="191" mass="22134" checksum="E64E722B52808AB6" modified="2020-02-26" version="1">MEGIVGRFIPSEWTYRNGSLSDCHLVQLEEYTQKYVNLKQQVAGAFNLGVRKIERVENPYLWGQYLLRKEELETNGFVREMELFHDTSIHNVQSIVETNLDWRLARRVKYGQGVSFSQSPAYANKESSRSNGTNRAFILTKVLVQNSEPVYSSVLLPSKGHDTTVGNCGKVYVKYYDDEFYPTYIIYYTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AH71</accession>
    <name>A0A5N4AH71_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase A2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_10753</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AH71"/>
    <dbReference type="InParanoid" id="A0A5N4AH71"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33198">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33198:SF20">
        <property type="entry name" value="RETROTRANSPOSON GAG DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0796692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="435" mass="49400" checksum="57B555675F6AD27E" modified="2020-02-26" version="1">MEFKPPANLSLQGNLSENWRKFRQNFEIYLKASDKSTKDDETKIAIQLNIIGEDAVEVYNTFTLSETDMVSFPAVLKAFDDHCSPKKNIVFERFKFFSRVQQEGEGFDQFLTDIKKLSKSCEFGLLSDEMVRDRIVLGIYDKVMQERLLRVEDLDLAKAVNLCRAAEISKSQARNLQGASVEVEVIKKKSANRNYKSVSKTSSERFECRRCQTVHGVRECPAFWRSCNKCGQLNHFAVSCQVKNVKVLQEQDEQSDELEFTINSIGVRNQNKKVLSIKSWFQNVNVGDHHVPIKFIKLDTGADVNVLSRKMLSEVGVPESQLQNTNIILEAFGGTVLKSLGIVPLKVQCNNVEFTDNFIIVDKIVSPLLGLESCTKLDLIARKVDALGKFMTKDEFIKNNLELFQDLGKFKDKCEIQINNEAIPVINPPRGICYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AH72</accession>
    <name>A0A5N4AH72_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Mitogen-activated protein kinase kinase kinase</fullName>
            <ecNumber evidence="3 12">2.7.11.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PPYR_10715</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">1611_PpyrPB1</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.25"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.25"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.25" evidence="3 12"/>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AH72"/>
    <dbReference type="FunCoup" id="A0A5N4AH72">
        <property type="interactions" value="389"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AH72"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004709">
        <property type="term" value="F:MAP kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017419">
        <property type="entry name" value="MAP3K12_MAP3K13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF304">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 13-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038165">
        <property type="entry name" value="MAPKKK12_MAPKKK13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 12 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="150"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="507"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="799"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="514"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="543"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="806"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="262"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="156"/>
            <end position="164"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR038165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR038165-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR038165-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAB0796654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="872" mass="98955" checksum="4DBF4BC81BD4613A" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AH79</accession>
    <name>A0A5N4AH79_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">[acyl-carrier-protein] S-malonyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.39</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">[Acyl-carrier-protein] malonyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PPYR_10714</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the type II malonyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.39" evidence="3"/>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AH79"/>
    <dbReference type="FunCoup" id="A0A5N4AH79">
        <property type="interactions" value="1466"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AH79"/>
    <dbReference type="OrthoDB" id="541883at2759"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004314">
        <property type="term" value="F:[acyl-carrier-protein] S-malonyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.250:FF:000005">
        <property type="entry name" value="Malonyl-CoA-acyl carrier protein transacylase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.250">
        <property type="entry name" value="Malonyl-CoA ACP transacylase, ACP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052760">
        <property type="entry name" value="Mitochondrial_malonyltrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47170">
        <property type="entry name" value="MALONYL-COA ACP TRANSACYLASE, ACP-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47170:SF2">
        <property type="entry name" value="MALONYL-COA:ACP TRANSACYLASE (MAT) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Malonyl-CoA:ACP transacylase (MAT)" evidence="13">
        <location>
            <begin position="86"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00061523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00077751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAB0796653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="394" mass="44409" checksum="3A764B7FF3D5FDF8" modified="2020-02-26" version="1">MLASRLRRCLRIRALHTSACRYNDDPKKESPLKAMLDDAASFDDVQVNKAQQQWATLPYLEGTKIRKQGEYYKKAKRDPKDASIILFPGQGNQFVGMGKDLLKFPIVRDLFELANYVLGYNLLKLCIEGPKQKLDQTRYCQPATVVTSLAAIERLKEERPSAIDNCVATAGYSLGEITALIFAGAIGFERGLQLVKIRAEAMQLASEVYQGGMAMVFYKPDTNLNNALTQAKDWALARGAEQPVCQIATYAFPHCKIVAGSIEAIEFLEKNYKELKLKRIRRLQVSGAFHTALMDPAIKPFARALETSDISDPVISVYSNVDGKVYRDAKHIKKQLPKQIVRPIKWEQLLHTVYERDPEEHFPRTFECGPGTSLKTMLKEVNAKAWDQCFSIEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AHP9</accession>
    <name>A0A5N4AHP9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RCR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="5">2.3.2.33</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PPYR_10895</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">1611_PpyrPB1</strain>
            <tissue evidence="19">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-threonine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-3-O-ubiquitinyl-L-threonine.</text>
            <dbReference type="EC" id="2.3.2.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Axon</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RING-Cys relay (RCR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.33" evidence="5"/>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A5N4AHP9">
        <property type="interactions" value="1906"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AHP9"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099174">
        <property type="term" value="P:regulation of presynapse organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008582">
        <property type="term" value="P:regulation of synaptic assembly at neuromuscular junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19799">
        <property type="entry name" value="Bbox2_MYCBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16463">
        <property type="entry name" value="RING-H2_PHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.820:FF:000002">
        <property type="entry name" value="E3 ubiquitin-protein ligase MYCBP2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000078">
        <property type="entry name" value="E3 ubiquitin-protein ligase MYCBP2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.820">
        <property type="entry name" value="PHR domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004939">
        <property type="entry name" value="APC_su10/DOC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017868">
        <property type="entry name" value="Filamin/ABP280_repeat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012983">
        <property type="entry name" value="PHR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038648">
        <property type="entry name" value="PHR_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45943">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MYCBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45943:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MYCBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08005">
        <property type="entry name" value="PHR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SMART" id="SM01337">
        <property type="entry name" value="APC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51284">
        <property type="entry name" value="DOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50194">
        <property type="entry name" value="FILAMIN_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="RCC1" evidence="15">
        <location>
            <begin position="936"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="13">
        <location>
            <begin position="2428"/>
            <end position="2467"/>
        </location>
    </feature>
    <feature type="domain" description="DOC" evidence="18">
        <location>
            <begin position="3738"/>
            <end position="3917"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="17">
        <location>
            <begin position="4449"/>
            <end position="4500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="104"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="550"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="822"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="2745"/>
            <end position="2783"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="2812"/>
            <end position="3005"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="104"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="552"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="562"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="2761"/>
            <end position="2778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="2841"/>
            <end position="2852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="2865"/>
            <end position="2878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="2888"/>
            <end position="2943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="2953"/>
            <end position="2971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="2982"/>
            <end position="2998"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAB0796834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="4697" mass="515712" checksum="8B21AC9F7600EA3B" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AIJ8</accession>
    <name>A0A5N4AIJ8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Protein krueppel</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PPYR_08100</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="6716973at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="Zgc:162936"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001290">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000072">
        <property type="entry name" value="zinc finger protein 143 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="zinc finger protein 16"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Zinc finger protein 574"/>
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    </dbReference>
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        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012934">
        <property type="entry name" value="Znf_AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF55">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07776">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00868">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51915">
        <property type="entry name" value="ZAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZAD" evidence="10">
        <location>
            <begin position="14"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="146"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
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            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="202"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="230"/>
            <end position="258"/>
        </location>
    </feature>
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            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
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            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="316"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="347"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="376"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="404"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="432"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0797106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="454" mass="52521" checksum="9D2FEF3383FF0387" modified="2020-02-26" version="1">MEIFPKYQHLQIEEICRICLTKKDPMQLLSDGGLLDMLIECVSIQLVEEDGVYLICNDCKSEISHWYVFKQQVVKAFAICRLLIKEKQQRVGDGERKLEDNESVTEKHWSCFVNNSCLEFGGAASSELSPLVNVTNADSMILKDDFKCSQCSKQCANHNALQRHLKRHAYGKVYECSKCTKVFKQSQTLADHMRRHYDNRNFACEVCGKKFYKQFNVTEHMRIHTGERPFKCESCERTFTRALLLRNHVKKAHTGDKKFICEVCSKSFVDGYQLKIHLRIHTGEKPFRCQYCDKSFAMQGQLKSHTKYRHTHEKNYICNVCARAFTAKHTLEEHLRTHTGVKKEPKHTCNICNKKCITTTQLRIHIKSVHTGERPFTCAICAKRFVTRTAVESHMKTHTGVKSFVCTDCGKGFNAKSSLKIHERIHTGERPYKCEYCDKTFAQGSTLKTHLKLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AIS3</accession>
    <name>A0A5N4AIS3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Haemolymph juvenile hormone binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_08244</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AIS3"/>
    <dbReference type="InParanoid" id="A0A5N4AIS3"/>
    <dbReference type="OrthoDB" id="8185902at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.30">
        <property type="entry name" value="Haemolymph juvenile hormone binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010562">
        <property type="entry name" value="Haemolymph_juvenile_hormone-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038606">
        <property type="entry name" value="To_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008:SF39">
        <property type="entry name" value="CIRCADIAN CLOCK-CONTROLLED PROTEIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008">
        <property type="entry name" value="PROTEIN TAKEOUT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06585">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00700">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024465541" description="Haemolymph juvenile hormone binding protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0797250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="242" mass="27277" checksum="C7D6E7515D6E3160" modified="2020-02-26" version="1">MYASLSLISLFVLVNAQLEIPDYIHICHRSDPNVADCIKSSVELLRPRLKEGIPELNVPSLEPFYVPDYDFGKGSSSLKILLKNTVAYGASEFEIVKLKVNVPDLTFGIQVLIPLIKLEGDFDINAQIVIPFKGQGRYSINASRGFGDAILYAEPKDGNGEYHLHFQRLELKVNVSEFHIALASPNFSNSLLIQTADNIVNQHKELFLEILMPLMERQLSVILLDIANKITKNFKYEEVFPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AKZ8</accession>
    <name>A0A5N4AKZ8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_09015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AKZ8"/>
    <dbReference type="FunCoup" id="A0A5N4AKZ8">
        <property type="interactions" value="37"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AKZ8"/>
    <dbReference type="OrthoDB" id="6693676at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902936">
        <property type="term" value="F:phosphatidylinositol bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1200">
        <property type="entry name" value="Alpha-tocopherol transfer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.20">
        <property type="entry name" value="N-terminal domain of phosphatidylinositol transfer protein sec14p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174">
        <property type="entry name" value="ALPHA-TOCOPHEROL TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174:SF216">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00180">
        <property type="entry name" value="CRETINALDHBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="90"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0798022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="307" mass="35125" checksum="BA002323A11AC72B" modified="2020-02-26" version="1">MNVRLLPSNLQSYAIKECKEDPSRVPEDVAHIREWLTKQPHLKTRTDDQWILRFLRGCKFSLDKTKEKLNNFYTLRSALPEFFANRDPYLPKIQQILQLGAILPIDVPEGPKVLLHRTTNIDPSQVLLIDVIKVWSMIADIMLNEDDHGAIYGYRIIIDLDTLNANHLLQATPIVTKKVVVCLKNVYPYRLKGAYFINMPSIFESILNLGKVLVGKKLSSRITVISKDSIQSLCEHVPISALPVEYGGCGETLEELTVKWKHKVESYKEWFLEEATYGCDESKRISESYTPSDSFGINGSFRKLNID</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ALN2</accession>
    <name>A0A5N4ALN2_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_09220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ALN2"/>
    <dbReference type="InParanoid" id="A0A5N4ALN2"/>
    <dbReference type="OrthoDB" id="1925699at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006616">
        <property type="entry name" value="DM9_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31649">
        <property type="entry name" value="AGAP009604-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31649:SF10">
        <property type="entry name" value="IP19903P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11901">
        <property type="entry name" value="DM9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00696">
        <property type="entry name" value="DM9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0798227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="164" mass="18107" checksum="926BE9DF2A02C813" modified="2020-02-26" version="1">MFGITFSNNITEHRQKSRVMTGYTWVASSHGRAAPPRAVQAGQDADGSLIYAGRAFFHGDTLPCKIVPQRREAYVSHNGREHNVSNYEYLVEQHMQWVSSSGSYIPPGAVPAGHTSSGETLYLGRVRHGNSITVGKVHPSHGCLYIPFGGNEVNYNSYEILVMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AMX4</accession>
    <name>A0A5N4AMX4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_09644</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AMX4"/>
    <dbReference type="FunCoup" id="A0A5N4AMX4">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AMX4"/>
    <dbReference type="OrthoDB" id="10048995at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11417">
        <property type="entry name" value="bHLH_TS_PTF1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000035">
        <property type="entry name" value="Pancreas-specific transcription factor 1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050283">
        <property type="entry name" value="E-box_TF_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23349:SF112">
        <property type="entry name" value="48 RELATED 1, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23349">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, TWIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="6">
        <location>
            <begin position="87"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="53"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="53"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0798651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="222" mass="24983" checksum="C4C5C35259013297" modified="2020-02-26" version="1">MFNMDNLDLDRQFFFEPGAFIGNNNNNTSGSSSSTNSGDLFLYDDNSSDSVGSAYSFNSDQENTSSGSKDRLHRHRRRSKCPQQQIQQRQAANLRERKRMQSINDAFEGLRAHIPTLPYEKRLSKVDTLKLAIGYINFLSELVRADRNSSTGGFSGLSRNNQRDEPKKIIVRGSGGLYTAHSLSWSRQKEPNSNGIMYAKVWTPEDPRANKTDGSSSFVLQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ANA9</accession>
    <name>A0A5N4ANA9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C-CAP/cofactor C-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PPYR_06674</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="6">Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TBCC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0798794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ANA9"/>
    <dbReference type="FunCoup" id="A0A5N4ANA9">
        <property type="interactions" value="1190"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4ANA9"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007023">
        <property type="term" value="P:post-chaperonin tubulin folding pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1250">
        <property type="entry name" value="Tubulin Binding Cofactor C, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017901">
        <property type="entry name" value="C-CAP_CF_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016098">
        <property type="entry name" value="CAP/MinC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006599">
        <property type="entry name" value="CARP_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027684">
        <property type="entry name" value="TBCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031925">
        <property type="entry name" value="TBCC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038397">
        <property type="entry name" value="TBCC_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012945">
        <property type="entry name" value="Tubulin-bd_cofactor_C_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15139">
        <property type="entry name" value="TUBULIN FOLDING COFACTOR C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15139:SF0">
        <property type="entry name" value="TUBULIN-SPECIFIC CHAPERONE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07986">
        <property type="entry name" value="TBCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16752">
        <property type="entry name" value="TBCC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00673">
        <property type="entry name" value="CARP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51329">
        <property type="entry name" value="C_CAP_COFACTOR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-CAP/cofactor C-like" evidence="7">
        <location>
            <begin position="151"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00026055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0798794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="333" mass="38749" checksum="48E8270801649C5A" modified="2020-02-26" version="1">MQERSDKLTTSLNKRELERKLDIEKKLEGKQQLIAEHEQLEYFTKSFNEKRIAVENALKSSSSVDVVDLPKHFDTIYKSILMLQKYGASSKIFLRMYDVERCHQTVHELTVRTRELEENLIPKKKFGFKNKKPNITDLNGRSEDVVDYAAPHQSYEESICGFENRKNETLIMQKSDVYKNDVVLQNIENCLIKLYGTPSTLHLNHVRNCLILSGPVSTSIFAEYCNDLKMAIACQQLRLHSSSDIHIYLHVTSRAIMEDCNNILIAPYNFKYDSLKEDFVTAGLDQNINNWTSVDDFNWLNLQKKSPNWSILQEHERISDWDNFTLPCGKFPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ANF3</accession>
    <name>A0A5N4ANF3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nose resistant-to-fluoxetine protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_06740</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0798860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ANF3"/>
    <dbReference type="InParanoid" id="A0A5N4ANF3"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006621">
        <property type="entry name" value="Nose-resist-to-fluoxetine_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052728">
        <property type="entry name" value="O2_lipid_transport_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161">
        <property type="entry name" value="O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161:SF0">
        <property type="entry name" value="O-ACYLTRANSFERASE LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20146">
        <property type="entry name" value="NRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00703">
        <property type="entry name" value="NRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="274"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="380"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="406"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="447"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="488"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="526"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="556"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="601"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="domain" description="Nose resistant-to-fluoxetine protein N-terminal" evidence="2">
        <location>
            <begin position="42"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0798860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="653" mass="73337" checksum="E0626AD7347E85EF" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ANQ5</accession>
    <name>A0A5N4ANQ5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Kinase</fullName>
            <ecNumber evidence="6">2.7.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PPYR_06840</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the inositol phosphokinase (IPK) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.-.-" evidence="6"/>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0798960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ANQ5"/>
    <dbReference type="FunCoup" id="A0A5N4ANQ5">
        <property type="interactions" value="132"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4ANQ5"/>
    <dbReference type="OrthoDB" id="338650at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000828">
        <property type="term" value="F:inositol hexakisphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.160:FF:000001">
        <property type="entry name" value="Kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.160">
        <property type="entry name" value="Inositol polyphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005522">
        <property type="entry name" value="IPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038286">
        <property type="entry name" value="IPK_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400:SF97">
        <property type="entry name" value="KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03770">
        <property type="entry name" value="IPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="231"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="252"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="279"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="356"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0798960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="812" mass="91933" checksum="BCA928131E3B52B1" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AP09</accession>
    <name>A0A5N4AP09_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PPYR_06903</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">1611_PpyrPB1</strain>
            <tissue evidence="20">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AP09"/>
    <dbReference type="FunCoup" id="A0A5N4AP09">
        <property type="interactions" value="7"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AP09"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009755">
        <property type="term" value="P:hormone-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15137">
        <property type="entry name" value="7tmA_Relaxin_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000023">
        <property type="entry name" value="Relaxin family peptide receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008112">
        <property type="entry name" value="Relaxin_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24372:SF80">
        <property type="entry name" value="FI21465P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24372">
        <property type="entry name" value="GLYCOPROTEIN HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01739">
        <property type="entry name" value="RELAXINR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 15" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="9 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 15" id="KW-0675">Receptor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="18" id="KW-0732">Signal</keyword>
    <keyword evidence="13 15" id="KW-0807">Transducer</keyword>
    <keyword evidence="5 15 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024377149" description="G-protein coupled receptors family 1 profile domain-containing protein" evidence="18">
        <location>
            <begin position="27"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="416"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="448"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="488"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="531"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="585"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="635"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="668"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="19">
        <location>
            <begin position="426"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="711"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="713"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="56"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAB0799023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="757" mass="85529" checksum="97F26F8FA4B48865" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AQL1</accession>
    <name>A0A5N4AQL1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Spectrin beta chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PPYR_07522</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">1611_PpyrPB1</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Probably plays an important role in neuronal membrane skeleton.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cell cortex</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the spectrin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A5N4AQL1">
        <property type="interactions" value="269"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AQL1"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045169">
        <property type="term" value="C:fusome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016328">
        <property type="term" value="C:lateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031594">
        <property type="term" value="C:neuromuscular junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008091">
        <property type="term" value="C:spectrin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045170">
        <property type="term" value="C:spectrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051693">
        <property type="term" value="P:actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016199">
        <property type="term" value="P:axon midline choice point recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042062">
        <property type="term" value="P:long-term strengthening of neuromuscular junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048790">
        <property type="term" value="P:maintenance of presynaptic active zone structure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007026">
        <property type="term" value="P:negative regulation of microtubule depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007274">
        <property type="term" value="P:neuromuscular synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd21246">
        <property type="entry name" value="CH_SPTB-like_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21248">
        <property type="entry name" value="CH_SPTB_like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10571">
        <property type="entry name" value="PH_beta_spectrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00176">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000020">
        <property type="entry name" value="Spectrin alpha chain, non-erythrocytic 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000003">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000004">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000011">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000018">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000019">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000028">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000033">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000049">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000059">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000083">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000106">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000024">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001589">
        <property type="entry name" value="Actinin_actin-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041681">
        <property type="entry name" value="PH_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001605">
        <property type="entry name" value="PH_dom-spectrin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018159">
        <property type="entry name" value="Spectrin/alpha-actinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016343">
        <property type="entry name" value="Spectrin_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002017">
        <property type="entry name" value="Spectrin_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11915">
        <property type="entry name" value="SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15410">
        <property type="entry name" value="PH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00435">
        <property type="entry name" value="Spectrin"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002297">
        <property type="entry name" value="Spectrin_beta_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00683">
        <property type="entry name" value="SPECTRINPH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00150">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00019">
        <property type="entry name" value="ACTININ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00020">
        <property type="entry name" value="ACTININ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4 12" id="KW-0117">Actin capping</keyword>
    <keyword evidence="9 12" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="16">
        <location>
            <begin position="48"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="16">
        <location>
            <begin position="167"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="15">
        <location>
            <begin position="2167"/>
            <end position="2279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="2112"/>
            <end position="2170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="2276"/>
            <end position="2311"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="451"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="990"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="1318"/>
            <end position="1345"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="1630"/>
            <end position="1664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="2112"/>
            <end position="2130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="2276"/>
            <end position="2293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00054264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR002297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAB0799642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="2311" mass="267011" checksum="09EF7DBB2EBE0087" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AQV2</accession>
    <name>A0A5N4AQV2_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PPYR_07556</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Complex I is composed of 45 different subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFB2 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AQV2"/>
    <dbReference type="FunCoup" id="A0A5N4AQV2">
        <property type="interactions" value="101"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AQV2"/>
    <dbReference type="OrthoDB" id="6241903at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026627">
        <property type="entry name" value="NDUFB2_animal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15223:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15223">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE AGGG SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14813">
        <property type="entry name" value="NADH_B2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAB0799676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="99" mass="11647" checksum="46FFD6006D828176" modified="2020-02-26" version="1">MLSSRGVQLVRSSKLLKNYQKISCTSVRNSGGEWIYRRPPPRQPEILYKLGEFVSAVSWWWILWHLWTEPGHVIGEFHYPNPRLWTNEELGISGFCQCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AQW0</accession>
    <name>A0A5N4AQW0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PPYR_07604</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">1611_PpyrPB1</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AQW0"/>
    <dbReference type="FunCoup" id="A0A5N4AQW0">
        <property type="interactions" value="72"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AQW0"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016500">
        <property type="term" value="F:protein-hormone receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009755">
        <property type="term" value="P:hormone-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15136">
        <property type="entry name" value="7tmA_Glyco_hormone_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000156">
        <property type="entry name" value="Lutropin-choriogonadotropic hormone receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002131">
        <property type="entry name" value="Gphrmn_rcpt_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24372">
        <property type="entry name" value="GLYCOPROTEIN HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24372:SF82">
        <property type="entry name" value="RICKETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00373">
        <property type="entry name" value="GLYCHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0807">Transducer</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="458"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="491"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="534"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="576"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="618"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="663"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="14">
        <location>
            <begin position="469"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="749"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="838"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="885"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1008"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="749"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="845"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="891"/>
            <end position="926"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAB0799724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1045" mass="117292" checksum="7E275BB357B44B16" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-06-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AS46</accession>
    <name>A0A5N4AS46_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_07973</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0800093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AS46"/>
    <dbReference type="InParanoid" id="A0A5N4AS46"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0800093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="121" mass="13951" checksum="D81783E4159EAD50" modified="2020-02-26" version="1">MSETARLLKNVRSVFFRKSHTRVDMEVELARKYFYSLHLLTASHTECTNANVYRNLSRVTFVNTQNWLTLVNRGKYALRCLKRECLILLDGFAFSQEEGGTVSQADVIRAYNTNIPKPDGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ATK2</accession>
    <name>A0A5N4ATK2_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed DNA polymerase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_06410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000004">
        <property type="protein sequence ID" value="KAB0800671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ATK2"/>
    <dbReference type="InParanoid" id="A0A5N4ATK2"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.960.10">
        <property type="entry name" value="VSR Endonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0800671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="225" mass="26169" checksum="D890320C91C2CB40" modified="2020-02-26" version="1">MQKEIVTYCVLDVDILTLACLKFRESLIKAGNVCPFSEACTIASSCNKLFRRNFLKPDTIGLIPRHGYRYRDKQSKIAIEWLIWEEKVRGINILHAAKGKEMVLGGLSVDGYCAETNQVFEMMGCFYHGCTKCFKNDRDKPVYNNGDETMNLRYENTRSKIVHLNQLGYEVIVKEKIFRPNLLKRRFISYESYPYGYKKFKTEEGEDNDNRESSFAEATMCLQEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AUD2</accession>
    <name>A0A5N4AUD2_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Prolyl endopeptidase</fullName>
            <ecNumber evidence="7">3.4.21.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PPYR_05336</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of Pro-|-Xaa &gt;&gt; Ala-|-Xaa in oligopeptides.</text>
            <dbReference type="EC" id="3.4.21.26"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the peptidase S9A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="7"/>
    <dbReference type="EMBL" id="VVIM01000003">
        <property type="protein sequence ID" value="KAB0800982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AUD2"/>
    <dbReference type="InParanoid" id="A0A5N4AUD2"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070012">
        <property type="term" value="F:oligopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000005">
        <property type="entry name" value="Prolyl endopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.120">
        <property type="entry name" value="Prolyl oligopeptidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002471">
        <property type="entry name" value="Pept_S9_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023302">
        <property type="entry name" value="Pept_S9A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002470">
        <property type="entry name" value="Peptidase_S9A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051167">
        <property type="entry name" value="Prolyl_oligopep/macrocyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42881">
        <property type="entry name" value="PROLYL ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42881:SF2">
        <property type="entry name" value="PROLYL ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02897">
        <property type="entry name" value="Peptidase_S9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00862">
        <property type="entry name" value="PROLIGOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00708">
        <property type="entry name" value="PRO_ENDOPEP_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S9A N-terminal" evidence="9">
        <location>
            <begin position="7"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="8">
        <location>
            <begin position="117"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU368024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0800982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="346" mass="39329" checksum="861A26F2DFDBC48A" modified="2020-02-26" version="1">MDNYQKVLEFPLPHGSVSGFSGKRDDSRMFFGFTSFLIPYDIYTVDFTEEPLNLVKWHQTVLPNFNPDNYICKQVFYSAIDGTQIPMSIVHKKNLVMEGENPCLLYGYGGFNVTIGPSFSVSRLVFMDKFNGIFAVANIRGGGEYGEKWHNAGRFKNKQLVFDDFQRAAWYLIDKDYTCSEKLTIQGASNGGLLVAACINQQPYLYGCALCLVGVLDMLRYHKFTIGYAWKSDYGCSDDAGQFDYLFKYSPLHNIKRPTEKGIVEYPATLLLTGDHDDRVVPLHSYKFIAELQYKVGQSYDQTKPLLIRIDTNSGHGAGKPTSKLIEEQAEMLCFMQKSLNLQYFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AV96</accession>
    <name>A0A5N4AV96_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HECT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_05603</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000003">
        <property type="protein sequence ID" value="KAB0801249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AV96"/>
    <dbReference type="InParanoid" id="A0A5N4AV96"/>
    <dbReference type="OrthoDB" id="6776505at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="4">
        <location>
            <begin position="529"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="39"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="2">
        <location>
            <position position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0801249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="601" mass="67897" checksum="A879D0890AB8F0EB" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AVD6</accession>
    <name>A0A5N4AVD6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PPYR_05689</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000003">
        <property type="protein sequence ID" value="KAB0801335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AVD6"/>
    <dbReference type="InParanoid" id="A0A5N4AVD6"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="7">
        <location>
            <begin position="30"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="84"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0801335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="117" mass="13332" checksum="05674C1985CACF35" modified="2020-02-26" version="1">MKNVRNSWCVDVLFCAPIISLLIFNNMPTINKCFICNNALDSDREIKCDKCGNHIHSTCAGLSQSELKCFSNKNRKLAYHCDECNKENSEISEIKQLILSLKAEIDELKSARSLEYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-06-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AVM7</accession>
    <name>A0A5N4AVM7_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_05743</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000003">
        <property type="protein sequence ID" value="KAB0801389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AVM7"/>
    <dbReference type="InParanoid" id="A0A5N4AVM7"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0801389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="232" mass="24732" checksum="28A04D050694D36F" modified="2020-02-26" version="1">MSSQDETASLLVGGPPLTTASSPANCSKPVLMRQECTTFLVSSHHPQLSVFSDSEEDGSLCLEENSTRSVPDIELHCRLDVKGCKQNLLTNIPTRNRSSSNAFQLAPHTSPRGALEQRRTSQTPTSALKIVRSVSRESVRSAHHCTCPCLNAPASCSSCPAPPTVVTTLPGSRIIRQSSQPEASAPCCVHGAAPSTSLRQLRDHGEGGIAGIAADSLRINGAMRNFRQHILE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AW77</accession>
    <name>A0A5N4AW77_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">TIR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PPYR_03762</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">1611_PpyrPB1</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Toll-like receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0801576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AW77"/>
    <dbReference type="OrthoDB" id="2015831at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001164">
        <property type="entry name" value="GH01279p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001438">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="entry name" value="Toll/interleukin-1 receptor homology (TIR) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000483">
        <property type="entry name" value="Cys-rich_flank_reg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000372">
        <property type="entry name" value="LRRNT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366">
        <property type="entry name" value="IG(IMMUNOGLOBULIN) AND LRR(LEUCINE RICH REPEAT) DOMAINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366:SF161">
        <property type="entry name" value="TIR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13676">
        <property type="entry name" value="TIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="22"/>
    </dbReference>
    <dbReference type="SMART" id="SM00082">
        <property type="entry name" value="LRRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00013">
        <property type="entry name" value="LRRNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00255">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="Toll/Interleukin receptor TIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50104">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 14" id="KW-0732">Signal</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024462141" description="TIR domain-containing protein" evidence="14">
        <location>
            <begin position="16"/>
            <end position="1323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1004"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="domain" description="TIR" evidence="15">
        <location>
            <begin position="1059"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1241"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1244"/>
            <end position="1259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1267"/>
            <end position="1276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAB0801576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1323" mass="149099" checksum="7DEF1C1C1063E141" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-06-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AX53</accession>
    <name>A0A5N4AX53_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_04024</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0801838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AX53"/>
    <dbReference type="InParanoid" id="A0A5N4AX53"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.20">
        <property type="entry name" value="Pheromone/general odorant binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036728">
        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024396823" evidence="1">
        <location>
            <begin position="18"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0801838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="139" mass="16250" checksum="BB6D23BA754E8BB9" modified="2020-02-26" version="1">MKASIGLFVFLCVQVFSTEVPEFVKDQDLIDCFHKLKFDKSVWKMFDEHYIIKNPDEDGIKLLDCALHVHGRNFFDEDEKLIKTHALKRIKEKIEEKGKESKDDVFEAIHEACKHTHGDTVVLKSVNFHNCITEEIMKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AXF8</accession>
    <name>A0A5N4AXF8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_04192</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AXF8"/>
    <dbReference type="InParanoid" id="A0A5N4AXF8"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050828">
        <property type="entry name" value="C-type_lectin/matrix_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45710:SF36">
        <property type="entry name" value="C-TYPE LECTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45710">
        <property type="entry name" value="C-TYPE LECTIN DOMAIN-CONTAINING PROTEIN 180"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-type lectin" evidence="1">
        <location>
            <begin position="26"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="1">
        <location>
            <begin position="170"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="1">
        <location>
            <begin position="310"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0802006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="462" mass="54811" checksum="D753D7D272C74DBF" modified="2020-02-26" version="1">MKFRLSSADDCMEFDWEDTKELSFVYLNKEYLILEYRVNWDEALIICQTFENGSLAIIRDLEVRTFLARCLEETAPNADTYWIGAERRKNAEHFFWIDNGEQFVDNNCFILRGTDYIRPQGRECLCFSRRNHNDGLYFNLDCKLKRALICERPFENKYDGSMTTAEWIIVNDYKYGIFYDRKSWSQAVRACQKYYNGELATFRNTNETGILGKYLLIGRPSLENAWIGGRYTESGWRFISDDVIIPDHKDSVTHFPPWFLNQTRQRGGCLVLDRHLANEAVFVETRCSRRMSYICSKKIVQTPEKVYHTFNNVEYTIYYIKQSWDEAYETCLAHNTTLVKVTLEVIHALVHMMGEMDYEIYHVWIGGRLNEDGTNFEWVEDNEIIKKQSEGIDWYPPWYDTEFDLKYPCLNMDRENHNRPMFYGADCGHAQEFICERKHTKVHASFGVMDDDDFQEIEGRMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AZ10</accession>
    <name>A0A5N4AZ10_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">IC97/Casc1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_04773</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNAI7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AZ10"/>
    <dbReference type="FunCoup" id="A0A5N4AZ10">
        <property type="interactions" value="8"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AZ10"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048487">
        <property type="term" value="F:beta-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022110">
        <property type="entry name" value="CASC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031826">
        <property type="entry name" value="IC97/Casc1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023247">
        <property type="entry name" value="IC97/Dnai7-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20929:SF11">
        <property type="entry name" value="DYNEIN AXONEMAL INTERMEDIATE CHAIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20929">
        <property type="entry name" value="LUNG ADENOMA SUSCEPTIBILITY 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12366">
        <property type="entry name" value="Casc1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15927">
        <property type="entry name" value="Casc1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02043">
        <property type="entry name" value="CANCERSCCP1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IC97/Casc1 N-terminal" evidence="4">
        <location>
            <begin position="133"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="CASC1 C-terminal" evidence="3">
        <location>
            <begin position="597"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="76"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="533"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF15927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0802587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="851" mass="98043" checksum="910880C78805E23E" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B0C3</accession>
    <name>A0A5N4B0C3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">USP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_00012</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B0C3"/>
    <dbReference type="InParanoid" id="A0A5N4B0C3"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0803042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1068" mass="122580" checksum="93B4FE786CA96CE8" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B0H0</accession>
    <name>A0A5N4B0H0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_00055</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B0H0"/>
    <dbReference type="InParanoid" id="A0A5N4B0H0"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0803085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="335" mass="38285" checksum="C616FAC4B3B3D054" modified="2020-02-26" version="1">MVRKQKPRQIGKTSVDVMTATTKLVLEENYSLRRAAEAYDISFITLRRYVLKKRSNPDADIKMSPNYSVRQILTEEQEVRLAEYINTCSKMAYGLSTKECRRLAWEMADVNKLSVPISWTANKQAGVEWLRQFMKRRKNLSIRQPEACSLSRLTSFNPHNVKKFFDQLKQIFEKKPQLVDPSRIFNLDETGTSTVQKPRKIVAEKGSKQVSQCSSAERGSLVTSCAIICANGTYLPPAMVFPRKYFKTHMVAGAPPGTLGLATPNGWMTAELFSARWRAGTIDYESIKKFAISFAMENWTGQERAFAVNAFYKNNDSYEQARRDVEWPARFPNLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B0Y4</accession>
    <name>A0A5N4B0Y4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sushi domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_00183</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B0Y4"/>
    <dbReference type="FunCoup" id="A0A5N4B0Y4">
        <property type="interactions" value="16"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4B0Y4"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46393:SF7">
        <property type="entry name" value="COMPLEMENT C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46393">
        <property type="entry name" value="SUSHI DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1 6" id="KW-0768">Sushi</keyword>
    <feature type="domain" description="Sushi" evidence="8">
        <location>
            <begin position="8"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="8">
        <location>
            <begin position="70"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="8">
        <location>
            <begin position="235"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="8">
        <location>
            <begin position="400"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="8">
        <location>
            <begin position="660"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="8">
        <location>
            <begin position="718"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="8">
        <location>
            <begin position="778"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="8">
        <location>
            <begin position="837"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="199"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="437"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="688"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="748"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="807"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="866"/>
            <end position="893"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0803213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="901" mass="100052" checksum="6FCB6743DFE6F3D8" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B285</accession>
    <name>A0A5N4B285_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_00470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B285"/>
    <dbReference type="InParanoid" id="A0A5N4B285"/>
    <dbReference type="OrthoDB" id="6767093at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0803500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="137" mass="15921" checksum="4473CBC3F1EAD541" modified="2020-02-26" version="1">MNPEEIDGSNSIQQLACNAREMLLPSKSKTVYEAAYREYRRWYWGKKINCTTEDCILAYFNSELVSYKSSSLWSKYSMLRSTINLNEGVDISKFPSLIPYLKRKGEGHKAKKSLTLDRENVNTFLLKASNKEHLLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B3L6</accession>
    <name>A0A5N4B3L6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PPYR_01098</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A5N4B3L6">
        <property type="interactions" value="236"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4B3L6"/>
    <dbReference type="OrthoDB" id="10042249at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000594">
        <property type="entry name" value="Transcription factor HIVEP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000145">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051969">
        <property type="entry name" value="Zinc-finger_DNA-bd_regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45944">
        <property type="entry name" value="SCHNURRI, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45944:SF2">
        <property type="entry name" value="SCHNURRI, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="230"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="258"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="1075"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="1103"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="1622"/>
            <end position="1649"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="1650"/>
            <end position="1679"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="1692"/>
            <end position="1721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="309"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="843"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1121"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="892"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1134"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1151"/>
            <end position="1162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1163"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1178"/>
            <end position="1202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAB0804128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1786" mass="199309" checksum="C04D9AAC216CDB56" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-09-13" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B4F7</accession>
    <name>A0A5N4B4F7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HECT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_01404</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B4F7"/>
    <dbReference type="InParanoid" id="A0A5N4B4F7"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0804434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="422" mass="47563" checksum="8BE28C53859F20C4" modified="2020-02-26" version="1">MVREIRGGGCRTITAHKTSTKKELLEEALNLFFPNGVSKFGSLNKFTYDLLDYQENAIEEKLTVGHMYNSSKLTSPRFYLVTNSLNSDTAEASTEMNCIDLDHDASQSIRKNVRKRSRSKAIENEDACSTSKSSNILDEFLSFDPETGGEPQSHFGTMEELEQLLQSNPESPSDSVQDATKVLVDVDELLFQKDFETAINNSLGIHQVEQRPMWTGTENTCSSLKEILMELNSKINTEKISKFNIYRADIFNCCNRALRRKMFSPFNKISVLFSDIEGNSEGAVDAGGPMREMFRLVIGYIQNSRMFFGEEKKYLTLDGEALQKEHYFEVGRLLALTLIHGGPTPSFSSKSLYSAVVGDGFSETDITLNDVESEIREKILKVDVINDFLALQKYVDDEAVFAIAGWPIIRKMEDKLAMLKDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B4H7</accession>
    <name>A0A5N4B4H7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_01424</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B4H7"/>
    <dbReference type="InParanoid" id="A0A5N4B4H7"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF269">
        <property type="entry name" value="NUCLEASE HARBI1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="8">
        <location>
            <begin position="200"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0804454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="429" mass="49942" checksum="13F6278F4CE6A261" modified="2020-02-26" version="1">MESINCRILLCSIGALVIKMNRCYPVQKYSLQQQVIKLYKLYKLVQKYHKTNKRMWVRDVFKEEQRLLQGTSSNLIMEMRRTDRNKFFNFLRMAPETFDLLLSIVGPYVQKKLLIREPIPAKVRLEITLRYLASGDSMTSLSYNFRVGKQSVSRIIFETCNAIWEGLKNKVFYDPTDAYWKTIAQTFEEKWNFKHCIGAIDGKHVNIQALPKSGSAYYNYKGTHSINLLAIADADYKFIMVDIGAPGRMSDSGIFRDSRLGMGFEQNNFHLPPPEDNLIVIVGDEAFPLTNYLMRPYPRRGDLDLRKKVFNYRLSRARRIVENAFGILVSKWRVFRKPIIASEDTVRKIVQACVCLHNFLLMQIAESQNYSRCEETNESVTTDGLSNIKRTGTNTFSRRAAQYRELFADYFCNAGAVEWQWQKALNNEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B5E6</accession>
    <name>A0A5N4B5E6_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_01738</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B5E6"/>
    <dbReference type="FunCoup" id="A0A5N4B5E6">
        <property type="interactions" value="695"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4B5E6"/>
    <dbReference type="OrthoDB" id="10259368at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030992">
        <property type="term" value="C:intraciliary transport particle B"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042073">
        <property type="term" value="P:intraciliary transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23683">
        <property type="entry name" value="IFT52_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039975">
        <property type="entry name" value="IFT52"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055460">
        <property type="entry name" value="IFT52_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055458">
        <property type="entry name" value="IFT52_GIFT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12969:SF7">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 52 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12969">
        <property type="entry name" value="NGD5/OSM-6/IFT52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23352">
        <property type="entry name" value="IFT52_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23355">
        <property type="entry name" value="IFT52_GIFT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IFT52 GIFT" evidence="2">
        <location>
            <begin position="13"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="IFT52 central" evidence="1">
        <location>
            <begin position="257"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0804768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="428" mass="48722" checksum="5405A3AB91D5E1F8" modified="2020-02-26" version="1">MAPIEINFDNKSTIIFNATKNELFKLNDNFKILQRKLKINWKLVVNKEEINDAVLQKCSILILPGCRNPFSESEIEAMKKYLDQGGKILVLLYESNQDDISNVNIILEHYGMVPNMDSLIRTHYYKYFHPKECYIEDGNILEALTKEKVQLNLVVPHGCTLNVNKPSVIVFTSGATTFPADRPLCGMYYNGNTGGTLVTIGSGHMFADKYIDQEHNEKFREYLFEFLASTDKVSVITDHDDDLEIWDHHIVPDITEIADRAKLCLTDAIGHAISTDYSKLFDHKMYSMNTDFVPQAVKLYDKLDVKHQTLKLISPNFEAPLPPLQAAVFPPSFRELPPPPLELFDLDEAFSSSLTRLAQFTNKFLSTTPSNDPTDQQLDFYIQECAKIVNVGIDSTDSKDILFEVATQCNKFKQNSARKQEEIEDGLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B7C3</accession>
    <name>A0A5N4B7C3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fucosyltransferase</fullName>
            <ecNumber evidence="7">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_02446</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Golgi apparatus</location>
            <location evidence="7">Golgi stack membrane</location>
            <topology evidence="7">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the glycosyltransferase 10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="7"/>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0805476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B7C3"/>
    <dbReference type="FunCoup" id="A0A5N4B7C3">
        <property type="interactions" value="27"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4B7C3"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008417">
        <property type="term" value="F:fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11660:FF:000006">
        <property type="entry name" value="Alpha-(1,3)-fucosyltransferase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11660">
        <property type="entry name" value="Glycosyl transferase family 10, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055270">
        <property type="entry name" value="Glyco_tran_10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001503">
        <property type="entry name" value="Glyco_trans_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038577">
        <property type="entry name" value="GT10-like_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48438">
        <property type="entry name" value="ALPHA-(1,3)-FUCOSYLTRANSFERASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48438:SF1">
        <property type="entry name" value="ALPHA-(1,3)-FUCOSYLTRANSFERASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00852">
        <property type="entry name" value="Glyco_transf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <feature type="domain" description="Fucosyltransferase C-terminal" evidence="8">
        <location>
            <begin position="33"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0805476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="232" mass="26982" checksum="36240EF268943111" modified="2020-02-26" version="1">MTYRFDSDIISRHGAFVKDESNNYSLPSVQVIKKKTKLVAWFASHCKTSSKREKLAEEMKKYLPVDIYGKCGTLKCEKARGNKLSSPKCYEMLENTYKFYLSFENSICKDYSTEKLYNVLKKNVVPIVYGAGNYSLSAPPYSVINVADFDTVKQLTDYLMHLDKNMTEYLKYFEWKKKFKIVEVRKGCDICKKLNEPLRKSVYDDLKSWSWGKKGEICKTGKNLPQIVQKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B7T1</accession>
    <name>A0A5N4B7T1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pacifastin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_02637</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0805667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B7T1"/>
    <dbReference type="InParanoid" id="A0A5N4B7T1"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024462142" description="Pacifastin domain-containing protein" evidence="1">
        <location>
            <begin position="26"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0805667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="99" mass="11400" checksum="DB2AD84FAD24CD37" modified="2020-02-26" version="1">MATHRVYVFNFVILLVTVLVFETFADSFVCDSNKRYQENKCNNCSCTVDQNQEVGFGCTKMFCDNEESAKLKSCDPAIPSPYKNCWCFRQWGTICEIPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1K671</accession>
    <name>A0A1Y1K671_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PPYR_03404</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="19 20" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">1611_PpyrPB1</strain>
            <tissue evidence="19">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">1611_PpyrPB1</strain>
            <tissue evidence="19">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="GEZM01091344">
        <property type="protein sequence ID" value="JAV56893.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A1Y1K671">
        <property type="interactions" value="31"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1K671"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050321">
        <property type="term" value="F:tau-protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14338">
        <property type="entry name" value="UBA_SIK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000003">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000156">
        <property type="entry name" value="Serine/threonine-protein kinase SIK3 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001772">
        <property type="entry name" value="KA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057380">
        <property type="entry name" value="UBA_SIK1/2/3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF42">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SIK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23312">
        <property type="entry name" value="UBA_SIK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50032">
        <property type="entry name" value="KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="17"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="KA1" evidence="17">
        <location>
            <begin position="1286"/>
            <end position="1334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="337"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="587"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="639"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="696"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1064"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1107"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="366"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="381"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="592"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="736"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="787"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1076"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1107"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="JAV56893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAB0791604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1335" mass="148444" checksum="A7E30DD622E19886" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1KAM9</accession>
    <name>A0A1Y1KAM9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RWD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_06778</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01089375">
        <property type="protein sequence ID" value="JAV57518.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0798898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A1Y1KAM9"/>
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    </dbReference>
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    <dbReference type="OrthoDB" id="432412at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23829">
        <property type="entry name" value="RWD_RWDD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd24163">
        <property type="entry name" value="RWDD2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017359">
        <property type="entry name" value="Phi-like"/>
    </dbReference>
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        <property type="entry name" value="Prp3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
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        <property type="entry name" value="RWDD2A-B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15955">
        <property type="entry name" value="RWD DOMAIN CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15955:SF8">
        <property type="entry name" value="RWD DOMAIN-CONTAINING PROTEIN 2B-RELATED"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF06544">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038021">
        <property type="entry name" value="UCP038021_RWDD2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RWD" evidence="1">
        <location>
            <begin position="23"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="JAV57518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0798898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="292" mass="34264" checksum="598A0152EEFAEBDE" modified="2017-08-30" version="1">MEPVFDTPLSRVKLTENLRTQLSELEMLESMFYNPGEIRVDDFNALREIRNFVNGTNDIIPPFLDITINLSIENLKYEFCINLSHEYPDVEPDIYIRNHKLNREQHAKINKGMSDYIGKLEKGEVCIFSAISWLQDNASCFVELEEEVPVKKVEESDELIRLWIYSHHIYSKTKRREIVDLASQLKLTGFCLPGKPGVICVEGYKRDCEEWWQAIKSMNWKRIFCKISEECKGGKEGSFLKFDNFEEKIFQNRDVKCNHMDMGELHKFLGMHNCDYIFKDLFGVDSRNNSAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1KF96</accession>
    <name>A0A1Y1KF96_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">hydroxyacylglutathione hydrolase</fullName>
            <ecNumber evidence="5">3.1.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Glyoxalase II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PPYR_13083</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an S-(2-hydroxyacyl)glutathione + H2O = a 2-hydroxy carboxylate + glutathione + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21864"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58896"/>
            <dbReference type="ChEBI" id="CHEBI:71261"/>
            <dbReference type="EC" id="3.1.2.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.6" evidence="5"/>
    <dbReference type="EMBL" id="GEZM01085157">
        <property type="protein sequence ID" value="JAV60172.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1KF96"/>
    <dbReference type="FunCoup" id="A0A1Y1KF96">
        <property type="interactions" value="753"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1KF96"/>
    <dbReference type="OrthoDB" id="515692at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004416">
        <property type="term" value="F:hydroxyacylglutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019243">
        <property type="term" value="P:methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07723">
        <property type="entry name" value="hydroxyacylglutathione_hydrolase_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.15.10:FF:000019">
        <property type="entry name" value="Hydroxyacylglutathione hydrolase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01374">
        <property type="entry name" value="Glyoxalase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035680">
        <property type="entry name" value="Clx_II_MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032282">
        <property type="entry name" value="HAGH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017782">
        <property type="entry name" value="Hydroxyacylglutathione_Hdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03413">
        <property type="entry name" value="GSH_gloB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11935">
        <property type="entry name" value="BETA LACTAMASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11935:SF94">
        <property type="entry name" value="TENZING NORGAY, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16123">
        <property type="entry name" value="HAGH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005457">
        <property type="entry name" value="Glx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="10">
        <location>
            <begin position="57"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="JAV60172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAB0793463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="303" mass="33840" checksum="32935F835B8045B2" modified="2017-08-30" version="1">MLQAIVTKLPNSVTQRLIATYYRVNSLRVNGLRNSHSAQNSIRFEKMKIRILPALSDNYMYLIIDEKTKQAAIVDPVSPDTVLQAVDEEGVNLTKVLTTHHHWDHAGGNEELVSKSKNALQIFGGDQRINALTNRVKHGDKFTIGDINVECLYTPCHTTGHICYYLTAEGQTPAVFTGDTLFIGGCGRFFEGTAEQMYAALVTLLGTLPDNTRVFCGHEYTVQNLKFAEHVEKENKDIQSKLQWAIDQRQRGLPTVPSTIAEEKLINPFMRVETPHVQKHSGAAEAIAVMASIRKEKDSFKAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1KK56</accession>
    <name>A0A1Y1KK56_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Amidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_13772</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the amidase family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01086074">
        <property type="protein sequence ID" value="JAV59796.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0794152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1KK56"/>
    <dbReference type="FunCoup" id="A0A1Y1KK56">
        <property type="interactions" value="10"/>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR43372:SF1">
        <property type="entry name" value="LD38433P"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="3">
        <location>
            <begin position="81"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="2">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="2">
        <location>
            <position position="216"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="2">
        <location>
            <position position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="JAV59796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0794152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="533" mass="59243" checksum="0B6F94A55D3E9475" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1KP59</accession>
    <name>A0A1Y1KP59_PHOPY</name>
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        <recommendedName>
            <fullName evidence="12">Nucleolar autoantigen 36</fullName>
        </recommendedName>
    </protein>
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        <name evidence="10" type="ORF">PPYR_15652</name>
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    <organism evidence="9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOA36 family.</text>
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        <property type="protein sequence ID" value="JAV63209.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010531">
        <property type="entry name" value="NOA36"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13214">
        <property type="entry name" value="ZINC FINGER PROTEIN 330"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13214:SF1">
        <property type="entry name" value="ZINC FINGER PROTEIN 330"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF06524">
        <property type="entry name" value="NOA36"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
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        </location>
    </feature>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00007212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="JAV63209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0790747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="115" mass="13148" checksum="BDD3A21C51521204" modified="2017-08-30" version="1">MPKKKTGQRKKAEKQKLRQKEIRTSRDNIGLAQHPCNAVMECEKCNRKQKNRAFCYFCQNLQRLPMCAQCGKTKCMAKAGDCVIRHPGIFTTGLNMIVRRLLKIMCIDCVVGSDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1KVT3</accession>
    <name>A0A1Y1KVT3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 11">Ornithine aminotransferase</fullName>
            <ecNumber evidence="6 11">2.6.1.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PPYR_04966</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 2-oxocarboxylate + L-ornithine = L-glutamate 5-semialdehyde + an L-alpha-amino acid</text>
            <dbReference type="Rhea" id="RHEA:13877"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="ChEBI" id="CHEBI:59869"/>
            <dbReference type="EC" id="2.6.1.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-ornithine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.13" evidence="6 11"/>
    <dbReference type="EMBL" id="GEZM01074344">
        <property type="protein sequence ID" value="JAV64591.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="interactions" value="1230"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1KVT3"/>
    <dbReference type="OrthoDB" id="425114at2759"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00358"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004587">
        <property type="term" value="F:ornithine aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019544">
        <property type="term" value="P:L-arginine catabolic process to L-glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010121">
        <property type="term" value="P:L-arginine catabolic process to proline via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000011">
        <property type="entry name" value="Ornithine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000152">
        <property type="entry name" value="Ornithine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050103">
        <property type="entry name" value="Class-III_PLP-dep_AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010164">
        <property type="entry name" value="Orn_aminotrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01885">
        <property type="entry name" value="Orn_aminotrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986">
        <property type="entry name" value="AMINOTRANSFERASE CLASS III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986:SF18">
        <property type="entry name" value="ORNITHINE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="9 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="JAV64591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAB0802780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="431" mass="47160" checksum="F9EC4BC23208918B" modified="2017-08-30" version="1">MPGTMQSVQNHINELVPSGAKDAKRDTKTSKSVFAREAKYGAHNYEPIPVAITRGQGVYVWDVEGKKYFDFLSAYSAVNQGHCHPRIVAALQKQAEILTLTSRAFYTDALGEYAQYITSVFGYDKVLPINSGVEAGETACKIARKWGYLKKKIPDNEAKIVFAEGNYWGRTLAAISSSTDPSCREHYGPFMPGFLIVPYNDLEALETTLKDDPNICAFMVEPIQGEAGIVIPSPGYLKGVRELCTKYNVLWIDDEVQTGMGRTGKLLAVEHEDVRPDIVCLGKALSGGMMAISAVLADDPIILCMKPGEHGSTYGGNPLACKVAIAALNVTIEERLTENAMHLGCLLKSELKQLPTSIVKEVRGKGLMCAIVINRDIGFTATEICLRLRDNGLLAKQTHSDIIRLAPPLVITEAQLRECTKIITNTICSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1KVV5</accession>
    <name>A0A1Y1KVV5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UBZ1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PPYR_06232</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01072487">
        <property type="protein sequence ID" value="JAV65502.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01072486">
        <property type="protein sequence ID" value="JAV65503.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000004">
        <property type="protein sequence ID" value="KAB0800492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1KVV5"/>
    <dbReference type="FunCoup" id="A0A1Y1KVV5">
        <property type="interactions" value="103"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1KVV5"/>
    <dbReference type="OrthoDB" id="6105729at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.250.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041641">
        <property type="entry name" value="CALCOCO1/2_Zn_UBZ1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18112">
        <property type="entry name" value="Zn-C2H2_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBZ1-type" evidence="6">
        <location>
            <begin position="289"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="15"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="214"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF18112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="JAV65502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0800492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="325" mass="37056" checksum="6A4FE93C586A304B" modified="2017-08-30" version="1">MEESCGAQYALQIALQTLRERCHQFQQRIAVLEEENLNLRCKASIRSEQADSSLSEVDSLRQQVSQLTEHNLQLTSNVLMVSAENRQLWNRLSRLTRANENLGSKLHKISDTLSNVTLSNSQSTLVRSKTFTQEEPHVKVVPRNVTDENNRISLELEDISLKLMCNIAKEKSELELQCSQMTELQNNEFINTFAFAYSAEEVDNTILDEFDQYLMNLKNIKHVLTQEKGKLQKNLNDLNSLSVYYQSTSVKPPIDKVSTFVQTNAQELVDEVAASAVTNEASKMDTCTKICPMCSKVFKGNVTFREFQDHVENHFTSDTETFDVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1KW32</accession>
    <name>A0A1Y1KW32_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="6">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_08628</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="GEZM01076836">
        <property type="protein sequence ID" value="JAV63605.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01076835">
        <property type="protein sequence ID" value="JAV63606.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1KW32"/>
    <dbReference type="InParanoid" id="A0A1Y1KW32"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000155">
        <property type="entry name" value="Carboxylic ester hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011807056" description="Carboxylic ester hydrolase" evidence="6">
        <location>
            <begin position="29"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="7">
        <location>
            <begin position="33"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="JAV63606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0797635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="607" mass="68518" checksum="8A87F779BA790EBB" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1L480</accession>
    <name>A0A1Y1L480_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">lactoylglutathione lyase</fullName>
            <ecNumber evidence="3">4.4.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Aldoketomutase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Ketone-aldehyde mutase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Methylglyoxalase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">S-D-lactoylglutathione methylglyoxal lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PPYR_02931</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">1611_PpyrPB1</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">1611_PpyrPB1</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13">Binds 1 zinc ion per subunit. In the homodimer, two zinc ions are bound between subunits.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glyoxalase I family.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.5" evidence="3"/>
    <dbReference type="EMBL" id="GEZM01068798">
        <property type="protein sequence ID" value="JAV66765.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1L480"/>
    <dbReference type="FunCoup" id="A0A1Y1L480">
        <property type="interactions" value="1043"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1L480"/>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="UniPathway" id="UPA00619">
        <property type="reaction ID" value="UER00675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004462">
        <property type="term" value="F:lactoylglutathione lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07233">
        <property type="entry name" value="GlxI_Zn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004361">
        <property type="entry name" value="Glyoxalase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018146">
        <property type="entry name" value="Glyoxalase_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00068">
        <property type="entry name" value="glyox_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10374:SF30">
        <property type="entry name" value="LACTOYLGLUTATHIONE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10374">
        <property type="entry name" value="LACTOYLGLUTATHIONE LYASE GLYOXALASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00934">
        <property type="entry name" value="GLYOXALASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="VOC" evidence="14">
        <location>
            <begin position="27"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="11">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="156"/>
            <end position="157"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR604361-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR604361-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR604361-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="JAV66765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAB0791131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="180" mass="20728" checksum="A9CB2535E65E9D23" modified="2017-08-30" version="1">MAGTIPITNDEAVKLCQEPENATQDFMFQQTMYRIKDPRKSLPFYTGVLGMRLLLKRDFPDMKFTLYFMGYEDASDFKGELSSIERTEWAMSQKATLELTHNWGTEDDPNFKGYHNGNSEPRGFGHIGLMVPNVDEACERFERLGVNFIKRPQDGKMKTIAFIADPDGYWIEILNNKHVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1L8Q3</accession>
    <name>A0A1Y1L8Q3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquinone biosynthesis O-methyltransferase, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">3-demethylubiquinol 3-O-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.64</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">3-demethylubiquinone 3-O-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.-</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Polyprenyldihydroxybenzoate methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.114</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">coq3</name>
        <name evidence="8" type="ORF">PPYR_00584</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">O-methyltransferase required for two non-consecutive steps during ubiquinone biosynthesis. Catalyzes the 2 O-methylation of 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoic acid into 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoic acid. Also catalyzes the last step of ubiquinone biosynthesis by mediating methylation of 3-demethylubiquinone into ubiquinone. Also able to mediate the methylation of 3-demethylubiquinol into ubiquinol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoate + S-adenosyl-L-methionine = a 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoate + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:44452"/>
            <dbReference type="Rhea" id="RHEA-COMP:10930"/>
            <dbReference type="Rhea" id="RHEA-COMP:10931"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64694"/>
            <dbReference type="ChEBI" id="CHEBI:84443"/>
            <dbReference type="EC" id="2.1.1.114"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 3-demethylubiquinol + S-adenosyl-L-methionine = a ubiquinol + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:44380"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="Rhea" id="RHEA-COMP:10914"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:84422"/>
            <dbReference type="EC" id="2.1.1.64"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 3-demethylubiquinone + S-adenosyl-L-methionine = a ubiquinone + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:81215"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:19654"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:231825"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of a multi-subunit COQ enzyme complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitochondrion inner membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.64" evidence="5"/>
    <dbReference type="EC" id="2.1.1.-" evidence="5"/>
    <dbReference type="EC" id="2.1.1.114" evidence="5"/>
    <dbReference type="EMBL" id="GEZM01062047">
        <property type="protein sequence ID" value="JAV70090.1"/>
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    <sequence length="278" mass="31422" checksum="DBBBE6FA112C809E" modified="2017-08-30" version="1">MLQRTGRCSASYYKNIIKPLVKLQTCGLQNDSTADKTEVKHFNQIRTGWWDEMGAVKPLHSMNKLRVPLIREGLINTGLIQKNFISTPKPLTNLKILEVGCGGGILTEALARLGCCITGIDVAGELLEIAKEHSASHPSRENINYQLTTIEKFAETNVEQFDAVVASEVLEHVDHQEQFVEACVRCLKPGGSIFLTTINQNLLSWFLVVPVAESILRLVPKGTHHYDKFISPHRTQKFLEHNNCRTRLVHGFFYNVLTNTWFWTSNTVVHYAMHAVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LG83</accession>
    <name>A0A1Y1LG83_PHOPY</name>
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        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PPYR_08802</name>
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    <organism evidence="7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
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            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
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    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
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                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8">1611_PpyrPB1</strain>
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        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
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                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="8">1611_PpyrPB1</strain>
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        </source>
    </reference>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="JAV70027.1"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAB0797809.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
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    </evidence>
    <sequence length="544" mass="60353" checksum="7035C0E74BF5066C" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LHC1</accession>
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        </alternativeName>
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        </alternativeName>
    </protein>
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            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
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            <taxon>Lampyrinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
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                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Mg(2+) is required for catalysis and for stabilizing the dimer.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the enolase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.11" evidence="3"/>
    <dbReference type="EMBL" id="GEZM01061503">
        <property type="protein sequence ID" value="JAV70427.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000004">
        <property type="protein sequence ID" value="KAB0800328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1LHC1"/>
    <dbReference type="InParanoid" id="A0A1Y1LHC1"/>
    <dbReference type="OrthoDB" id="1739814at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00187"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000015">
        <property type="term" value="C:phosphopyruvate hydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004634">
        <property type="term" value="F:phosphopyruvate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03313">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="entry name" value="Enolase-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="entry name" value="Enolase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00318">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000941">
        <property type="entry name" value="Enolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020810">
        <property type="entry name" value="Enolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020809">
        <property type="entry name" value="Enolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020811">
        <property type="entry name" value="Enolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902:SF1">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00113">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03952">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001400">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00148">
        <property type="entry name" value="ENOLASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00001">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01192">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01193">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="Enolase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="Enolase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00164">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enolase N-terminal" evidence="12">
        <location>
            <begin position="3"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Enolase C-terminal TIM barrel" evidence="11">
        <location>
            <begin position="141"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="JAV70427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAB0800328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="434" mass="46868" checksum="C27CD2426CF233DA" modified="2017-08-30" version="1">MPIKSVYARQVINSSGQPTVEVDLVTDLGLFRAAVSSEEPNDKIATHLKDGEPRNFYGISVLKAVTNVNQSIGPALVKQGYEVTQQRQIDELMIKLDGTENKSNFGANAILGVSMAVAKAGAAKRGIPLYKHLADLSGNRQLIIPTPAFSVIAGGILSSNKVAMQDIMILPTGAHTFAEALKMGAEVRETLKGIIGQKFGKDATAVNAKGAFVPNFPNDKDALKCIVDAIGKAGYTGRVELALDCAATTWYKQGKYDLNYKNPKSDKAKWLLGSKLQDTYYRDLMKTFPIVSLEDPFIVDDIVSWNKMLQAYPSLQIVGDTLTLMNQTKIQEVADKKACNCVLIKLNQIGTVTETIDAHLIAKQNGVGSMVAHGLHDTADSFIADLAVGLATGQIKTGGLCKSECVAKYNQILRIEEELASNAKYAGRAFRCPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LIR5</accession>
    <name>A0A1Y1LIR5_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PPYR_14185</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GEZM01060786">
        <property type="protein sequence ID" value="JAV70917.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1LIR5"/>
    <dbReference type="FunCoup" id="A0A1Y1LIR5">
        <property type="interactions" value="1987"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1LIR5"/>
    <dbReference type="OrthoDB" id="196858at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037850">
        <property type="entry name" value="RBBP5/Swd1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44040">
        <property type="entry name" value="RETINOBLASTOMA-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44040:SF1">
        <property type="entry name" value="RETINOBLASTOMA-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117289">
        <property type="entry name" value="Nucleoporin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="62"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="346"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="444"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="346"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="JAV70917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0792226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="478" mass="52887" checksum="6ACF1D4F6EC33F06" modified="2017-08-30" version="1">MNLELLESFGQNYPEEFDGALDCLSIAVTCSFNKRGTLLAVGCNDGRIVIWDFLTRGIAKIISAHVHPVCSVSWNRNGHKIATASTDNTVCVWDVLSGECDQKFRFPCPVLRVQFQPRNLERLLVCPMRHAAVLVEINGQHQVLPIDEDGDLNIVASYDRRGEHVFTGNSKGKILVLKADTLEVRASFRITLGSSSATAIKSIEFARRGDCFLVNTADRVIRVYDSKEVLACGKDGEPEPIQKLQDLVNKTMWKKCCFSGDGEYICAGSARQHALYIWEKSIGNLVKILHGTKGELLLDVAWHPVRPIIASISSGVVSVWAQNQVENWSAFAPDFKELDENVEYEERESEFDLTDEDKSVASGDDAKEDVDLEVDVSTVEPVAAFCSSDEEQENADVLQFLPIAPEIEDPEENWCADVISQPPTSGTNSPPIKKSKYRAYDIPIESTSDGEIHPLLTNKIKEKQGIGGGKKGTGRSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LS01</accession>
    <name>A0A1Y1LS01_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Casein kinase I isoform alpha</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">CK1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PPYR_12442</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">1611_PpyrPB1</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">1611_PpyrPB1</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="GEZM01052663">
        <property type="protein sequence ID" value="JAV74346.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0795603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1LS01"/>
    <dbReference type="FunCoup" id="A0A1Y1LS01">
        <property type="interactions" value="888"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1LS01"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14128">
        <property type="entry name" value="STKc_CK1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000120">
        <property type="entry name" value="Casein kinase I isoform alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000538">
        <property type="entry name" value="Putative Casein kinase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="18"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="312"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="316"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00071374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00082669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="JAV74346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAB0795603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="333" mass="38413" checksum="08775CB452205FDA" modified="2017-08-30" version="1">MMSSSTIVKTEFIVGGKYRLVRKIGSGSFGDIYLGINITNGEEVAVKLESVRARHPQLLYESKLYKILHGGVGIPHIRYYGQEKEYNVLVMDLLGPSLEDLFNFCSRRFTIKTVLMLADQMIGRIEYVHCKSFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDARTRCHIAYREDKNLTGTARYASINAHLGIEQSRRDDMESLGYVLMYFNRGCLPWQGLKAATKKQKYEKISEKKMSTPVEVLCKGFPAEFSMYLNYCRGLRFEEAPDYMYLRQLFRILFRTLNHQYDYTFDWTMLKQKGASMTGAVGTSAQPQTSQAITQQQPGNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1M4G9</accession>
    <name>A0A1Y1M4G9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Adenylyltransferase and sulfurtransferase MOCS3 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">UBA4 homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Ubiquitin-like protein activator 4 homolog</fullName>
        </alternativeName>
        <domain>
            <recommendedName>
                <fullName evidence="11">Adenylyltransferase</fullName>
                <ecNumber evidence="11">2.7.7.-</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="11">Sulfurtransferase</fullName>
                <ecNumber evidence="11">2.8.1.-</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PPYR_04790</name>
        <name evidence="15" type="ORF">PPYR_15299</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">1611_PpyrPB1</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">1611_PpyrPB1</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Acts by mediating the C-terminal thiocarboxylation of the sulfur carrier URM1. Its N-terminus first activates URM1 as acyl-adenylate (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 to form thiocarboxylation (-COSH) of its C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards URM1. Subsequently, a transient disulfide bond is formed. Does not use thiosulfate as sulfur donor; NFS1 probably acting as a sulfur donor for thiocarboxylation reactions.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="11">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">In the N-terminal section; belongs to the HesA/MoeB/ThiF family. UBA4 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.-" evidence="11"/>
    <dbReference type="EC" id="2.8.1.-" evidence="11"/>
    <dbReference type="EMBL" id="GEZM01041086">
        <property type="protein sequence ID" value="JAV80621.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01041084">
        <property type="protein sequence ID" value="JAV80623.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000761">
        <property type="protein sequence ID" value="KAB0790789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1M4G9"/>
    <dbReference type="FunCoup" id="A0A1Y1M4G9">
        <property type="interactions" value="410"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1M4G9"/>
    <dbReference type="OrthoDB" id="10261062at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070566">
        <property type="term" value="F:adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate-cyanide sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042292">
        <property type="term" value="F:URM1 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032447">
        <property type="term" value="P:protein urmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00757">
        <property type="entry name" value="ThiF_MoeB_HesA_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.250.10:FF:000014">
        <property type="entry name" value="Adenylyltransferase and sulfurtransferase MOCS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000033">
        <property type="entry name" value="Adenylyltransferase and sulfurtransferase MOCS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03049">
        <property type="entry name" value="MOCS3_Uba4"/>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
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        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
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                <person name="Bessho-Uehara M."/>
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                <person name="Debat H.J."/>
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                <person name="Day J.C."/>
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                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
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                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
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                <person name="Stanger-Hall K.F."/>
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                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
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            <dbReference type="PubMed" id="30324905"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8 9">Belongs to the glycosyl hydrolase 9 (cellulase E) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.4" evidence="9"/>
    <dbReference type="EMBL" id="GEZM01037479">
        <property type="protein sequence ID" value="JAV82050.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01037478">
        <property type="protein sequence ID" value="JAV82051.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1MBW0"/>
    <dbReference type="InParanoid" id="A0A1Y1MBW0"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001701">
        <property type="entry name" value="Glyco_hydro_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033126">
        <property type="entry name" value="Glyco_hydro_9_Asp/Glu_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22298">
        <property type="entry name" value="ENDO-1,4-BETA-GLUCANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00759">
        <property type="entry name" value="Glyco_hydro_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00698">
        <property type="entry name" value="GH9_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 9" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="6 8 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8 9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011807064" description="Endoglucanase" evidence="9">
        <location>
            <begin position="19"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 9" evidence="10">
        <location>
            <begin position="27"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="425"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="JAV82050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAB0791627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="456" mass="51470" checksum="F50C0EA7583AE203" modified="2017-08-30" version="1">MVQVLTAIIAGLIAHVACHPFDVQPNYKEVLRLSLLFYEAQRSGRLPVDNRIAWRGDSALEDRGLNGEDLTGGYYDAGDFVKFSFPMAFTTTLLAWGVLDYENAYKSADQYHHAIIALKWATDYFLKCHVSPYELYGQVGDFSIDHKFWGRPEELNMTRPAYKIDTKHPGADLAGEVSAALSSTALVFKNIQKDYYSLAIRHAQELYAFAVNYPGFYHEAIPGAKAFYQSTGFGDELTWAAIWLYKATLDQKYLQDAELFYKNFKLKGRPNEFHHTNKVAGIQVLLAELTGKSEYVRAVEAFCNYSIYQQKRTPKGLVYIDKAGTLSHAANIVFLCLQAVDMNISSSSYIHFAREQMSYILTTTGRSFVVGYGENYPKKPHHSASSCPDKPNPCGWESYKSKDPNPKILYGALVSGPDQNDHYEDVREEFLYNEVTLDYNAGFQSAAAGLLQYENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1MFI5</accession>
    <name>A0A1Y1MFI5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sorting nexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_04241</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in several stages of intracellular trafficking.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the sorting nexin family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01033083">
        <property type="protein sequence ID" value="JAV84423.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1MFI5"/>
    <dbReference type="FunCoup" id="A0A1Y1MFI5">
        <property type="interactions" value="1133"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1MFI5"/>
    <dbReference type="OrthoDB" id="9976382at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090389">
        <property type="term" value="P:phagosome-lysosome fusion involved in apoptotic cell clearance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07621">
        <property type="entry name" value="BAR_SNX5_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06892">
        <property type="entry name" value="PX_SNX5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000008">
        <property type="entry name" value="Sorting nexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000001">
        <property type="entry name" value="Sorting nexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014637">
        <property type="entry name" value="SNX5/SNX6/SNX32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015404">
        <property type="entry name" value="Vps5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45850:SF1">
        <property type="entry name" value="SORTING NEXIN 6, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45850">
        <property type="entry name" value="SORTING NEXIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09325">
        <property type="entry name" value="Vps5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036924">
        <property type="entry name" value="Snx5_Snx6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="5">
        <location>
            <begin position="14"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR036924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="JAV84423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0802055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="395" mass="45438" checksum="8E90A67E32F8B155" modified="2017-08-30" version="1">MTERGTPDEGNNVPLIDNSLLVDISDALSEKDKVKFTVHTRTTLKGFQKCECLVVRQHEEFIWLHDRYEENPIYAGYIIPPPPPRPNFDASREKLQRLGEGEGTMTKEEFTKMKQELEAEYLATFKKTVAMHEVFLTRLASHSVFREDNHLHVFLEFDQDLCARPKGRLQQLGGIVKSLGSTTDQYYLGATVRDVNDFFEQQMNSITEYHSHLKEATIRTDKMTEKHKEVADSYIKISGGLLQLANVDSGPLNKFLAKVSDYFERARKTESRVASDQDLKLADTIRYYMRDSQAAKALLVRRLRCLANYEAANRTLEKARHKNKEVHAAEGAQTSACEQFESISAQAKEELLDFKTRRLHAFRKSLIELAELELKHARTQQELIRKSIQSLQELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1MTV5</accession>
    <name>A0A1Y1MTV5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Single domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PPYR_03105</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
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        <location>
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        <location>
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        </location>
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        <location>
            <begin position="40"/>
            <end position="115"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="JAV86817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0791305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="142" mass="15713" checksum="817F737DCEB27134" modified="2017-08-30" version="1">MKFVLIFASFFVFAVCQKEEAKIFKRLIPADVLRDFPGMCFASTKCATVDPGKSWELTPFCGRSTCVQSKEKSNVLLELVEDCGPLPIANPKCKLDEEKTNKTAEFPNCCPVFTCEPGAVLEYPDIATVEPVKEDVTPKPKA</sequence>
</entry>
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    <accession>A0A1Y1MVQ1</accession>
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        <recommendedName>
            <fullName evidence="6">UBR-type domain-containing protein</fullName>
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    </protein>
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        <name evidence="9" type="ORF">PPYR_07642</name>
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        <name type="scientific">Photinus pyralis</name>
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        <name type="synonym">Lampyris pyralis</name>
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            <taxon>Coleoptera</taxon>
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    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
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                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
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        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
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</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
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        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
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            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
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        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
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            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
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                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
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                <person name="Oba Y."/>
                <person name="Weng J.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
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    </reference>
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        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
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        <reaction evidence="8">
            <text>(S)-malate + NAD(+) = oxaloacetate + NADH + H(+)</text>
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            <dbReference type="ChEBI" id="CHEBI:15378"/>
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        </reaction>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
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    </dbReference>
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    </dbReference>
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            <begin position="10"/>
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        </location>
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            <begin position="160"/>
            <end position="331"/>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU003405"/>
        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="JAV88816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAB0799231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="336" mass="36191" checksum="E9D5EC2C6200203C" modified="2017-08-30" version="1">MSHLDKQPIRVVVTGAAGQIAYSLLYIIAKGDVFGRDQPLILHLLDIPPMMEVLEGVVMELADCALPLLRQVVPTADPAVAFNDVSAAFLVGAMPRKQGMERKDLLSANVKIFKVQGEALDKHARKDVKVLVVGNPANTNAIVCSKYAPSIPAENFTAMTRLDHNRARAQIAARANVPVPCVSNVIIWGNHSSTQVPDASHAKVNVNGKMVSASEAVKDEAWLRKQFIETVQKRGAAVIAARKMSSAMSAATAAADHMRSWFLGTDPDEFVSMGVVSDGSYGAPKGVVFSFPVTISNGQWKIVQGLKIDDFYLDMLAATGKELEEERAEAMAVIQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1MZQ0</accession>
    <name>A0A1Y1MZQ0_PHOPY</name>
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            <fullName evidence="6">Thioredoxin domain-containing protein</fullName>
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        <name evidence="8" type="ORF">PPYR_14169</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
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    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
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                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
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    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioredoxin family.</text>
    </comment>
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    </dbReference>
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        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:cell redox homeostasis"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Thioredoxin"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="JAV91142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0792210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="142" mass="15945" checksum="91AF6FEF45162E00" modified="2017-08-30" version="1">MLSLNVFRQISSKCVVPQMKYRQRGFGSTGIVNGTFKVQDDKDFSEKVENSKEPVIVDFFATWCGPCRALEPRLENVVAKRHGKVSLAKVDIDAFGEIAAKYEVGTIPALVVFRNGKVEERLIGLQDEDKLGLWVDKVLDKK</sequence>
</entry>
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    <name>A0A1Y1N752_PHOPY</name>
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        <recommendedName>
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        </recommendedName>
    </protein>
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    </gene>
    <organism evidence="3">
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            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
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            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
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                <person name="Al-Wathiqui N."/>
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            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01010908">
        <property type="protein sequence ID" value="JAV93732.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01010904">
        <property type="protein sequence ID" value="JAV93736.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01010903">
        <property type="protein sequence ID" value="JAV93737.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1N752"/>
    <dbReference type="FunCoup" id="A0A1Y1N752">
        <property type="interactions" value="192"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1N752"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053011">
        <property type="entry name" value="SDR_family_member_7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44269">
        <property type="entry name" value="DEHYDROGENASE/REDUCTASE SDR FAMILY MEMBER 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44269:SF1">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE SDR FAMILY MEMBER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
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        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="284"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="JAV93732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0796787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="333" mass="36882" checksum="6D3A948A67FF7039" modified="2017-08-30" version="1">MIAAIICIAIACYIIFYTITICLIDCDVELAFYEKFGKSIGHLKGKVVFITGASSGIGKHTALTLAKYGVKLVLAARRRNCLEEVRSQCITNSGGQLTVNDVLVLPMDMLDINSHQKQFDMALAHFGQIDILLNNAGRSQRAFWEMTHLTVDKELFELNVFSVVNLTRIAVNYFNSRGHGHVAVTSSLAGVVPIPYSGSYSGAKYAIHGYFNSLRIEKLRTNLKLAVTLLCPGPTYTEFLQHSFIEVPGKSYGISASTTDRRLTGERCGYLCAVALANETRESWMGIFPVLPFSYLSVYFPVITNWIVAIVTPQKMFKMRDGNEGIVTEVHTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1N880</accession>
    <name>A0A1Y1N880_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PPYR_03605</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">1611_PpyrPB1</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">1611_PpyrPB1</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="GEZM01010664">
        <property type="protein sequence ID" value="JAV93929.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1N880"/>
    <dbReference type="FunCoup" id="A0A1Y1N880">
        <property type="interactions" value="539"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1N880"/>
    <dbReference type="OrthoDB" id="10016527at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06607">
        <property type="entry name" value="STKc_TAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000030">
        <property type="entry name" value="Serine/threonine-protein kinase TAO2, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000029">
        <property type="entry name" value="Serine/threonine-protein kinase TAO2, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051234">
        <property type="entry name" value="TAO_STE20_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47167">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TAO1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47167:SF4">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE TAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="28"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="323"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="498"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="429"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="591"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="323"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="340"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="355"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="498"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="JAV93929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAB0791805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="893" mass="103946" checksum="A2691C4A68D04730" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1N8L6</accession>
    <name>A0A1Y1N8L6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">15-hydroxyprostaglandin dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_10158</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01009879">
        <property type="protein sequence ID" value="JAV94251.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1N8L6"/>
    <dbReference type="FunCoup" id="A0A1Y1N8L6">
        <property type="interactions" value="119"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1N8L6"/>
    <dbReference type="OrthoDB" id="417891at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000149">
        <property type="entry name" value="15-hydroxyprostaglandin dehydrogenase [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229:SF8">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="JAV94251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0796097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="269" mass="29412" checksum="0B2F2318D92967E4" modified="2017-08-30" version="1">MFDVYGKVALVTGGASGLGFLYVKELLRNGIKGVTIADTNDVFGERAIEEIKNEYGDEKAIFVNVDVSDKYQLEEAFKSTIQVFENIDIVINNAGILNDANWEKEIQVNLNGTVNGTLLAFDHYIATYKSGAEGAIINISSIGGLDAFATAPIYTASKFGIVGLGQAYGSKLHYERNNIKVVTVCPGFTLASLSDVVNHDSLLGTAYSKIMHKEYDSIPVQSPTFLAKSVISIIQQSEPGSVWVVEGEESPYEVEFPNRLLRKKKKQNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1NC39</accession>
    <name>A0A1Y1NC39_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_11350</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01007027">
        <property type="protein sequence ID" value="JAV95471.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0794511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1NC39"/>
    <dbReference type="InParanoid" id="A0A1Y1NC39"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012464">
        <property type="entry name" value="DUF1676"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07898">
        <property type="entry name" value="DUF1676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036029942" evidence="2">
        <location>
            <begin position="21"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="JAV95471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0794511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="130" mass="14488" checksum="24FA70E4C42A31CF" modified="2017-08-30" version="1">MMFWCFLVVLVTASIEKVYLQTVSSGARELSAVRRSLDPTPRTVSAWSILNQVAMTDDSTEEVGRKRKKGKFKKKLKRFMLPLLLAYKMKFFTLIPILVGGLILLTASTGLAGFFFALFAASLGLKTGYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1NI75</accession>
    <name>A0A1Y1NI75_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP synthase F1 subunit epsilon</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_05238</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase inhibitor family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01002454">
        <property type="protein sequence ID" value="JAV97248.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000003">
        <property type="protein sequence ID" value="KAB0800884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1NI75"/>
    <dbReference type="FunCoup" id="A0A1Y1NI75">
        <property type="interactions" value="873"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1NI75"/>
    <dbReference type="OrthoDB" id="10045676at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042030">
        <property type="term" value="F:ATPase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.500:FF:000007">
        <property type="entry name" value="ATPase inhibitor, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.500">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007648">
        <property type="entry name" value="ATPase_inhibitor_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48417">
        <property type="entry name" value="ATP SYNTHASE F1 SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48417:SF1">
        <property type="entry name" value="ATP SYNTHASE F1 SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04568">
        <property type="entry name" value="IATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64602">
        <property type="entry name" value="F1 ATPase inhibitor, IF1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="JAV97248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0800884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="105" mass="11884" checksum="D78DCCCA2C5D3D01" modified="2017-08-30" version="1">MNSIIVRPSIFRIFSQIRYMSQLGDLGSGAGKGGGGGGSIREAGGAFGKQEAAREEEYFYKKQREQLEKLKADLTEEISFHEEQIKRHQDAISRHKKRVTDIEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1NJ65</accession>
    <name>A0A1Y1NJ65_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein bL35m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">39S ribosomal protein L35, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PPYR_11687</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial ribosomal protein bL35 family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01003615">
        <property type="protein sequence ID" value="JAV96675.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0794848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1NJ65"/>
    <dbReference type="FunCoup" id="A0A1Y1NJ65">
        <property type="interactions" value="941"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1NJ65"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021137">
        <property type="entry name" value="Ribosomal_bL35-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037229">
        <property type="entry name" value="Ribosomal_bL35_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019338">
        <property type="entry name" value="Ribosomal_bL35m"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15909">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L35, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15909:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL35M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01632">
        <property type="entry name" value="Ribosomal_L35p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143034">
        <property type="entry name" value="L35p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="JAV96675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0794848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="177" mass="20977" checksum="6A1BA8957F8D8506" modified="2017-08-30" version="1">MLNINRLFLAFQPTKLTNLFANRSSNSLLKYVPLAQSSYKQYSTGFSGQPSTLLQNSTLVDISNSINSRSVTKFSIKKGKRKTVKTVLMRFYRLNWGGWVRTIAGRHRRMWSKSYPRQVRVRQHVLCNSTQCTLLDKMVTNYWRKPKYYVEDPYEPYHTREEFEFTARKPRAYFPPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1NKI9</accession>
    <name>A0A1Y1NKI9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Large ribosomal subunit protein uL4 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_09131</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL4 family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01001949">
        <property type="protein sequence ID" value="JAV97440.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1NKI9"/>
    <dbReference type="FunCoup" id="A0A1Y1NKI9">
        <property type="interactions" value="1170"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1NKI9"/>
    <dbReference type="OrthoDB" id="10259785at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1370.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025755">
        <property type="entry name" value="Ribos_uL4_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002136">
        <property type="entry name" value="Ribosomal_uL4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023574">
        <property type="entry name" value="Ribosomal_uL4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013000">
        <property type="entry name" value="Ribosomal_uL4_euk/arc_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045240">
        <property type="entry name" value="Ribosomal_uL4_euk/arch"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19431">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14374">
        <property type="entry name" value="Ribos_L4_asso_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00573">
        <property type="entry name" value="Ribosomal_L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52166">
        <property type="entry name" value="Ribosomal protein L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00939">
        <property type="entry name" value="RIBOSOMAL_L1E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL4 C-terminal" evidence="5">
        <location>
            <begin position="278"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="390"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="397"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="JAV97440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0798138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="432" mass="48696" checksum="65A4CAFEEF0CFD59" modified="2017-08-30" version="1">MSLAAARPLISVYGEKGEHVKGVTVSLPAVFKAPIRPDVVNFVHQQMAFNSRQPYAVSDKAGHQTSAESWGTGRAVARIPRVRGGGTHRSGQGAFGNMCRGGRMFAPTKVWRRWHRRININQRRYALSSAVAASGVPALVMSKGHVVEKVPELPLVISDKIEEFTKTKQAVLFLKRLKAWDEIQKVYKSQRMRAGKGKMRNRRRIQRKGPLIVYNKDQGLRRAFRNIPGVDMICIKKLNLLKLAPGGHVGRFIIWTQSAFEQLDKLFGTWSSSSEVKKDYNLPQPKMANTDLTRLLKSEEILKALRKPQGKVVKSVRRRNPLTNIRTMLRLNPYAAVLKRHAILTAQKRRNARDLALAKKRGVTLPKNHPAVVAERTKERRLTAIKKHLAKKHPEKVKKAEEAAKARAEKKVKKAVPKKGEAKKKAAPKQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N3ZZ81</accession>
    <name>A0A5N3ZZ81_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed DNA polymerase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_15260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01001402">
        <property type="protein sequence ID" value="KAB0790372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N3ZZ81"/>
    <dbReference type="InParanoid" id="A0A5N3ZZ81"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.60">
        <property type="entry name" value="N-acetyl transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511">
        <property type="entry name" value="PROTEIN CBG23764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511:SF12">
        <property type="entry name" value="RHO TERMINATION FACTOR N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="His-Me finger endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="921"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0790372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="921" mass="106610" checksum="83FD4C504200025A" modified="2020-02-26" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N3ZZI6</accession>
    <name>A0A5N3ZZI6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Paired domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PPYR_15110</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">1611_PpyrPB1</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the paired homeobox family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01001210">
        <property type="protein sequence ID" value="KAB0790484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N3ZZI6"/>
    <dbReference type="FunCoup" id="A0A5N3ZZI6">
        <property type="interactions" value="82"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N3ZZI6"/>
    <dbReference type="OrthoDB" id="3225452at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007365">
        <property type="term" value="P:periodic partitioning"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009791">
        <property type="term" value="P:post-embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00131">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000035">
        <property type="entry name" value="paired box protein Pax-3 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000003">
        <property type="entry name" value="Paired box protein Pax-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000031">
        <property type="entry name" value="Paired box protein Pax-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043182">
        <property type="entry name" value="PAIRED_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001523">
        <property type="entry name" value="Paired_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043565">
        <property type="entry name" value="PAX_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45636:SF49">
        <property type="entry name" value="PAIRED BOX PROTEIN 3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45636">
        <property type="entry name" value="PAIRED BOX PROTEIN PAX-6-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00292">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00027">
        <property type="entry name" value="PAIREDBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00351">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00034">
        <property type="entry name" value="PAIRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51057">
        <property type="entry name" value="PAIRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6 10 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 10 11" id="KW-0371">Homeobox</keyword>
    <keyword evidence="9 10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0563">Paired box</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Paired" evidence="14">
        <location>
            <begin position="22"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="13">
        <location>
            <begin position="175"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="10">
        <location>
            <begin position="177"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="149"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="280"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="149"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAB0790484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="411" mass="45215" checksum="4E1B06DEC1C61121" modified="2020-02-26" version="1">MTVTGNLGIMHRPCFSGYPFQGQGRVNQLGGVFINGRPLPNHIRLKIVEMAAAGVRPCVISRQLRVSHGCVSKILNRYQETGSIRPGVIGGSKPRLATPEIETRIEQYKKENPSIFSWEIRDRLVKEGICDRSTAPSVSAISRLLRGKGNDCDDKSTDNENGSDCESEPGIPLKRKQRRSRTTFTAHQLDELEKAFERTQYPDIYTREELAQRTKLTEARIQVWFSNRRARLRKQLASTSSSGSYAPLSNPYTATSSPYSVSEATFSTAPVAPNQMTELYSHGHASPNLPLTTQSHAPYPTQPLYSPPSLMPHANDLNQNGVFKDDAPYTTNNNLNLLSAATAVSPNGNDSPCRGDWITPNATSVDQVLTLGQPLGVPSQGFGANGLHPAAGYTPHNAKSFTHQPFYSWYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A048</accession>
    <name>A0A5N4A048_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PPYR_14848</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Abd-B homeobox family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000874">
        <property type="protein sequence ID" value="KAB0790705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A048"/>
    <dbReference type="InParanoid" id="A0A5N4A048"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000166">
        <property type="entry name" value="homeobox protein Hox-C11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000047">
        <property type="entry name" value="HTH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046333">
        <property type="entry name" value="HXA10/ABDB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45874">
        <property type="entry name" value="HOMEOBOX PROTEIN ABDOMINAL-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45874:SF4">
        <property type="entry name" value="HOMEOBOX PROTEIN ABDOMINAL-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00031">
        <property type="entry name" value="HTHREPRESSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0371">Homeobox</keyword>
    <keyword evidence="6 7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="10">
        <location>
            <begin position="20"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="7">
        <location>
            <begin position="22"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="72"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="86"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="101"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0790705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="131" mass="15404" checksum="8C0330C48298CB80" modified="2020-02-26" version="1">MGVGVPCGASTNPLEWTGQVTVRKKRKPYSKFQTLELEKEFLFNAYVSKQKRWELARNLNLTERQVKIWFQNRRMKNKKNSQRQSQQQQNNNNATTNNQNHHGHHVTHHPHTPHHVVNHHVAANGTLKHHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A149</accession>
    <name>A0A5N4A149_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_02854</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A149"/>
    <dbReference type="FunCoup" id="A0A5N4A149">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A149"/>
    <dbReference type="OrthoDB" id="10255480at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017216">
        <property type="entry name" value="HPS3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029438">
        <property type="entry name" value="HPS3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029437">
        <property type="entry name" value="HPS3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28633:SF1">
        <property type="entry name" value="BLOC-2 COMPLEX MEMBER HPS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28633">
        <property type="entry name" value="HERMANSKY-PUDLAK SYNDROME 3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14763">
        <property type="entry name" value="HPS3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14761">
        <property type="entry name" value="HPS3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BLOC-2 complex member HPS3 N-terminal" evidence="1">
        <location>
            <begin position="4"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="BLOC-2 complex member HPS3 C-terminal" evidence="2">
        <location>
            <begin position="543"/>
            <end position="821"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0791054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1155" mass="132151" checksum="0790328E47E4F1B3" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A183</accession>
    <name>A0A5N4A183_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">LRRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_02828</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A183"/>
    <dbReference type="InParanoid" id="A0A5N4A183"/>
    <dbReference type="OrthoDB" id="6755118at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050541">
        <property type="entry name" value="LRR_TM_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369">
        <property type="entry name" value="ANTIGEN BSP, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369:SF210">
        <property type="entry name" value="CHAOPTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0791028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="520" mass="58480" checksum="6E316F06020FDC96" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A327</accession>
    <name>A0A5N4A327_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BLOC-1-related complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PPYR_03479</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">1611_PpyrPB1</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the BORCS5 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A327"/>
    <dbReference type="FunCoup" id="A0A5N4A327">
        <property type="interactions" value="371"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A327"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099078">
        <property type="term" value="C:BORC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098574">
        <property type="term" value="C:cytoplasmic side of lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032418">
        <property type="term" value="P:lysosome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072384">
        <property type="term" value="P:organelle transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903744">
        <property type="term" value="P:positive regulation of anterograde synaptic vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22789">
        <property type="entry name" value="BORCS5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10508">
        <property type="entry name" value="Zn-ribbon_RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000004">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000009">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019761">
        <property type="entry name" value="DNA-dir_RNA_pol-M_15_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018780">
        <property type="entry name" value="TBORCS5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001529">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034012">
        <property type="entry name" value="Zn_ribbon_RPB9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31634">
        <property type="entry name" value="BLOC-1-RELATED COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31634:SF2">
        <property type="entry name" value="BLOC-1-RELATED COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10158">
        <property type="entry name" value="LOH1CR12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02150">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00661">
        <property type="entry name" value="RPOL9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01030">
        <property type="entry name" value="RNA_POL_M_15KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 15" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="13" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="11" id="KW-0458">Lysosome</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 15" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS-type" evidence="17">
        <location>
            <begin position="84"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="117"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="130"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAB0791679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="377" mass="43208" checksum="3D4B9175E2610EE4" modified="2020-02-26" version="1">MSRYDSHSEGPGFVGIRFCQECNNMLYPKEDKENKILMYACRNCDYKQHADSKCIYVNKIMHEIDELMHIVPDVISDPTLPRTEDHHCPKCHHREAVFFQAQTRRAEEEMRLYYMGSEHSSHGQLPRRQATLSGNSVRQSGNFRRQHTIANPGGEMLDHEPRPGSTSPGPSVCSDIDLPYISYTVNRPIGDSPKLTKQAVKAKANQRKVQQKAVKKSAHNIVVVKQAVTGPNVDKDPDIVRLQSIPMFLPIMRGTLYLPAPRDPEVLERLDSSPFYRLCLRYQNHLTTCTNTVATEQNIITQKVRETDAEINKLVAYATDRQKRFAKYAEKLSKVQELSHQLNRCHMVLNQTLESMETLNNCLDIDDRLEPFVWTTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A343</accession>
    <name>A0A5N4A343_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="26">BIG2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">PPYR_03545</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">1611_PpyrPB1</strain>
            <tissue evidence="24">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NUP210 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A5N4A343">
        <property type="interactions" value="1374"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A343"/>
    <dbReference type="OrthoDB" id="361283at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003343">
        <property type="entry name" value="Big_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058779">
        <property type="entry name" value="Ig_NUP210_13th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057586">
        <property type="entry name" value="Ig_NUP210_16th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055096">
        <property type="entry name" value="Ig_NUP210_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055097">
        <property type="entry name" value="Ig_NUP210_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055098">
        <property type="entry name" value="Ig_NUP210_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056897">
        <property type="entry name" value="Ig_NUP210_4th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056898">
        <property type="entry name" value="Ig_NUP210_6th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055099">
        <property type="entry name" value="Ig_NUP210_7th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056899">
        <property type="entry name" value="Ig_NUP210_9th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008964">
        <property type="entry name" value="Invasin/intimin_cell_adhesion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045197">
        <property type="entry name" value="NUP210-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055094">
        <property type="entry name" value="NUP210_Ig15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055095">
        <property type="entry name" value="NUP210_Ig_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23019:SF0">
        <property type="entry name" value="NUCLEAR PORE MEMBRANE GLYCOPROTEIN 210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23019">
        <property type="entry name" value="NUCLEAR PORE MEMBRANE GLYCOPROTEIN GP210-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02368">
        <property type="entry name" value="Big_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26181">
        <property type="entry name" value="Ig_NUP210_13th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26183">
        <property type="entry name" value="Ig_NUP210_14th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22959">
        <property type="entry name" value="Ig_NUP210_15th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25354">
        <property type="entry name" value="Ig_NUP210_16th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22967">
        <property type="entry name" value="Ig_NUP210_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22969">
        <property type="entry name" value="Ig_NUP210_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22963">
        <property type="entry name" value="Ig_NUP210_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24991">
        <property type="entry name" value="Ig_NUP210_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26182">
        <property type="entry name" value="Ig_NUP210_5th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24935">
        <property type="entry name" value="Ig_NUP210_6th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22962">
        <property type="entry name" value="Ig_NUP210_7th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24902">
        <property type="entry name" value="Ig_NUP210_9th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22957">
        <property type="entry name" value="NUP210_Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49373">
        <property type="entry name" value="Invasin/intimin cell-adhesion fragments"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024271084" description="BIG2 domain-containing protein" evidence="11">
        <location>
            <begin position="21"/>
            <end position="1888"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1795"/>
            <end position="1816"/>
        </location>
    </feature>
    <feature type="domain" description="NUP210 Ig-like" evidence="17">
        <location>
            <begin position="21"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="NUP210 Ig-like" evidence="18">
        <location>
            <begin position="120"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="NUP210 Ig-like" evidence="16">
        <location>
            <begin position="234"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="NUP210 fourth Ig-like" evidence="21">
        <location>
            <begin position="337"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="NUP210 Ig-like" evidence="20">
        <location>
            <begin position="520"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="domain" description="NUP210 Ig-like" evidence="15">
        <location>
            <begin position="632"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="domain" description="NUP210 Ig-like" evidence="19">
        <location>
            <begin position="883"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="domain" description="BIG2" evidence="12">
        <location>
            <begin position="1060"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="domain" description="NUP210 Ig-like" evidence="23">
        <location>
            <begin position="1148"/>
            <end position="1263"/>
        </location>
    </feature>
    <feature type="domain" description="NUP210 Ig-like" evidence="14">
        <location>
            <begin position="1371"/>
            <end position="1471"/>
        </location>
    </feature>
    <feature type="domain" description="NUP210 Ig-like" evidence="22">
        <location>
            <begin position="1480"/>
            <end position="1538"/>
        </location>
    </feature>
    <feature type="domain" description="NUP210 C-terminal Ig-like" evidence="13">
        <location>
            <begin position="1559"/>
            <end position="1711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1849"/>
            <end position="1888"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF22957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF22959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF22962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF22963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF22967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF22969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF24902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF24935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF24991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF25354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF26181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KAB0791745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="26">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1888" mass="208642" checksum="0C02F57D70F2B72E" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A3D4</accession>
    <name>A0A5N4A3D4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CUB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_03612</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A3D4"/>
    <dbReference type="InParanoid" id="A0A5N4A3D4"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058698">
        <property type="entry name" value="CUB_metazoa"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33236:SF11">
        <property type="entry name" value="CUB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33236">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 122 FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26080">
        <property type="entry name" value="CUB_animal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024342378" description="CUB domain-containing protein" evidence="3">
        <location>
            <begin position="22"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="4">
        <location>
            <begin position="297"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0791812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="612" mass="69649" checksum="AECA53797B9F31BF" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A3K6</accession>
    <name>A0A5N4A3K6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">LRRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_03682</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A3K6"/>
    <dbReference type="InParanoid" id="A0A5N4A3K6"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001164">
        <property type="entry name" value="GH01279p"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001438">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366">
        <property type="entry name" value="IG(IMMUNOGLOBULIN) AND LRR(LEUCINE RICH REPEAT) DOMAINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366:SF170">
        <property type="entry name" value="RE50361P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="29"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0791882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="842" mass="93974" checksum="1390F72052FA3D3A" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A5C1</accession>
    <name>A0A5N4A5C1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">G-protein coupled receptors family 2 profile 2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PPYR_14437</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 2 family. Mth subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A5C1"/>
    <dbReference type="FunCoup" id="A0A5N4A5C1">
        <property type="interactions" value="151"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A5C1"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15039">
        <property type="entry name" value="7tmB3_Methuselah-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.180.11">
        <property type="entry name" value="Methuselah ectodomain, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023311">
        <property type="entry name" value="Methusela_ecto_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036272">
        <property type="entry name" value="Methuselah_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051384">
        <property type="entry name" value="Mth_GPCR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47154">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR MTH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47154:SF2">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR MTH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63877">
        <property type="entry name" value="Methuselah ectodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024272993" description="G-protein coupled receptors family 2 profile 2 domain-containing protein" evidence="11">
        <location>
            <begin position="24"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="208"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="231"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="334"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="385"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="418"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="12">
        <location>
            <begin position="173"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAB0792478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="468" mass="53872" checksum="7712BE0E832721DE" modified="2020-02-26" version="1">MKCAIRPLFAPVIILSLVTVVLNTCEIQFNHKGEDYVLGDYVYNGTISECGCDNRTNICIRKCCDLNYTLSDQTCIFNDTQSFKIAVYDDVNPVAENLTFRYVAGRVKCPKGISHYRLEPLDYPDETFYFQPNGSLWQPEVNKLIYRENYCLENFHDIGLSAFVCVDGPPEEPKSLYTLGMIISMPFLLATFIVYGLLPERNMHGKSLMSYVISLFGAYLFLVIIQEHTEIVGAGCIALGTLCLFFFMVSFLWMNVMSIDIWWTFKGIRGLSGNKKEVEQKRFLMYSIYSWGVPLVYIIIITIINVSAPPNAWYKPGIGDGQCWFSQSIPELLYFYGPMALIIVLNLVLFGVTALKIRKMQKDTQMLRSGQYKKHSEDEQRQFKLYIRLFLAMGVNWIMEIVSWTVNWKVGSIPRSVWYLTDFCNAAYGVVIFFIFVFKKRIWKTLRTRYPCGSKQSCKDESDLTATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A5L6</accession>
    <name>A0A5N4A5L6_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_14551</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A5L6"/>
    <dbReference type="InParanoid" id="A0A5N4A5L6"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007623">
        <property type="term" value="P:circadian rhythm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.15.10.30:FF:000001">
        <property type="entry name" value="Takeout-like protein 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.30">
        <property type="entry name" value="Haemolymph juvenile hormone binding protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010562">
        <property type="entry name" value="Haemolymph_juvenile_hormone-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038606">
        <property type="entry name" value="To_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008:SF18">
        <property type="entry name" value="BCDNA.GH05536-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008">
        <property type="entry name" value="PROTEIN TAKEOUT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06585">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00700">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0090">Biological rhythms</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024386313" evidence="4">
        <location>
            <begin position="16"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00060902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0792592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="496" mass="56257" checksum="7F3B88326CE09417" modified="2020-02-26" version="1">MKWFLLYFLAVGVVALELPPDFPKCKRSDPKLNDCMKTAIEGALKLMEKGLPEFKVEPIQPITVPSLTIGQGKGPVQVVQNYENFKIYNLPSAKVADLSSRLSDSEFKMNITFLFKEVYLASQYKLNGKILLLPIVGEGDCTIKLMNAKVPMEMVGRFFEKKGVKYAEISDIKVHLGGDKVEFDFKNLFNGDPRLGPEMNRILNENWKEIFDDVKYAYDEAFGAIFKNIVNLIVRKVPYDELLPIIILFLPKRPKKINSNLKTFSIIASFKKQETPNFLKCKRSDPKINDCLKPAVGRAIHIMAEGMPDFKIEPIQPIRVPSLKIEGSVTQSYEDFQIFNVPSAKITHLDSSITDDEFNLNLTVFLKDIHIAARYKLQGQILLLPIVGEGNCTTDLRNAKVSLALSGVPTEKTGRKNVEIRSLKVNLDPEKVEFDFENLFNGDTQLGPQMNRIMNENSREIFNDVRHGYEEALGAVFKNIANLIFKRIPYDELVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A5X5</accession>
    <name>A0A5N4A5X5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PPYR_14684</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A5X5"/>
    <dbReference type="FunCoup" id="A0A5N4A5X5">
        <property type="interactions" value="21"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A5X5"/>
    <dbReference type="OrthoDB" id="1684102at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF680">
        <property type="entry name" value="PROTON-COUPLED AMINO ACID TRANSPORTER 4-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="240"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="279"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="317"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="385"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="426"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="42"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0792725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="453" mass="50002" checksum="EA5DBEF3141A48F0" modified="2020-02-26" version="1">MVQEQHTNFEPDRSVETNSEKTTAVNTTNDYDPYSHRVVRRPTTNLETLVHLFKCSCGTGILAMPKAFSYSGYTVGIIGTIVIGFLVTYCVHLIIRCEYELCKRRRVASLTYPGIAEAAFADGPKAMQKIAPYAGHVINAFLFVYQMGSCCVYLVFIAVNVEAVVSQYTEGYGTEMYILMFLVPLVLINWIRDLKRLAPLSTVANCVTLVSLAIILYYTIERGPTFSARKPVGDLRDFPLFFGTVIFAIEAIGVIIPLENEMKHPQAFGGTFGVLNQGMGAIVVLYGCVGLLGYLSYGSTTEGTVTLNLPKDEIVAQIVKVSLASSIFISYTIQYYVAIDIAWNHYLGPKFEKHPRVGLIEYTLRTFLVVLTCALAAAVPALDLFISLFGALCLSAVGIAIPAAIECGTFWYQTRGWRLCWMITKNVALVLFGLCGLIVGTYTSLRDIIARFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A6E9</accession>
    <name>A0A5N4A6E9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Sensory neuron membrane protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PPYR_14798</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CD36 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A6E9"/>
    <dbReference type="InParanoid" id="A0A5N4A6E9"/>
    <dbReference type="OrthoDB" id="195015at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005044">
        <property type="term" value="F:scavenger receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007608">
        <property type="term" value="P:sensory perception of smell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002159">
        <property type="entry name" value="CD36_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11923">
        <property type="entry name" value="SCAVENGER RECEPTOR CLASS B TYPE-1 SR-B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11923:SF109">
        <property type="entry name" value="SENSORY NEURON MEMBRANE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01130">
        <property type="entry name" value="CD36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01609">
        <property type="entry name" value="CD36FAMILY"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0552">Olfaction</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00040645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAB0792839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="185" mass="20701" checksum="6DEE996F01A7858A" modified="2020-02-26" version="1">MHKDSFVAPDEQGCVCIHATKGLDGSSHCYKKGVLDMNRCLGVPVIVSFPHLMWADEAYRNTITDEFSSENESYTTIVDFEPHLGIPLRGAIRLQFNVIMRPININKQVLPMTEKWPRAMFPIFWLEDGFQLTDELVEEIDSKLVGPLTLADAVQWSVVGVGAALSVLSIILLLACRRSEKLALQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-06-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A6X0</accession>
    <name>A0A5N4A6X0_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_12628</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A6X0"/>
    <dbReference type="InParanoid" id="A0A5N4A6X0"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024452344" evidence="1">
        <location>
            <begin position="19"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0793008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="250" mass="28809" checksum="F81CD6B91D4D3BDD" modified="2020-02-26" version="1">MWASLFLLLFAHTGKCLADFAFISNLDRDVEIQSCVARVIEQTFGLSRRFTYIYNDYIEYLPSAIANPIIVINARKPWSHHYNFYEAMYVIEAFDSGTLRETMKALKESTLWHPHSTREGKFVILTNEKDLASIFRAVWKFSILHVVLVVFEDGTNGKVVTSDPKTQENGCGLTPKLFDYQDCDANLAIKFLSPMRNYNQCPVFIDFHNPYDHRLKYIKPLLPVIEDVLNTTSIRVREPPSKPEMMAVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A6Y8</accession>
    <name>A0A5N4A6Y8_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_12714</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A6Y8"/>
    <dbReference type="FunCoup" id="A0A5N4A6Y8">
        <property type="interactions" value="164"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A6Y8"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="304"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="527"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="859"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="945"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="415"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="334"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="586"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="626"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="881"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="946"/>
            <end position="956"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0793094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1215" mass="138974" checksum="278F69313495C55A" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A784</accession>
    <name>A0A5N4A784_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">L-xylulose reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PPYR_12807</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A784"/>
    <dbReference type="FunCoup" id="A0A5N4A784">
        <property type="interactions" value="244"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A784"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004090">
        <property type="term" value="F:carbonyl reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050038">
        <property type="term" value="F:L-xylulose reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005997">
        <property type="term" value="P:xylulose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000214">
        <property type="entry name" value="L-xylulose reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051737">
        <property type="entry name" value="L-xylulose/Carbonyl_redctase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44252">
        <property type="entry name" value="D-ERYTHRULOSE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44252:SF3">
        <property type="entry name" value="D-ERYTHRULOSE REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0793187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="270" mass="28962" checksum="3F698CFE2D67EC52" modified="2020-02-26" version="1">MDIHFNGKTALVSGAGRGIGNAIAKRLALCGAQVTALDINRDNLERLSEEVPSVKTICVDLSNWSETKEALKHVGQIDLLVNNAGIAILEPLADISDGNIDRLFSINFKAVVNLTQIVAQSLQDRNASGSIVNISSQTSMRGLREHAIYSSTKAAVDAFTRVAALELGGQNVRINCVNPTVVMTELGREVWSDQRAAEEMKTKIPLKRFAEVDEVVDAVLFLLSDKANMITGTCLSVDALIIVLSFGGHSKQRQLPAPTNTSPIAGPLDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A7F0</accession>
    <name>A0A5N4A7F0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_12876</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A7F0"/>
    <dbReference type="InParanoid" id="A0A5N4A7F0"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33332">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0793256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="136" mass="15443" checksum="43FB1E16C42217A4" modified="2020-02-26" version="1" fragment="single">YYNSLKSRISICQHEFIHKRSTSTNLCSFYQFAVEILDNHGQVDVIYTDLSKAFDCISHSLLLTKLRIFGLSDCLLALLESYLKNRQQVVVYNGYSSIAYEAKTGVPQGSNLGPLLFLFKRVWCVYMNGVALTNSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A7Z2</accession>
    <name>A0A5N4A7Z2_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">LRRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PPYR_13054</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A7Z2"/>
    <dbReference type="InParanoid" id="A0A5N4A7Z2"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051432">
        <property type="entry name" value="KCNMA1_auxiliary"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46473">
        <property type="entry name" value="GH08155P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46473:SF10">
        <property type="entry name" value="LD45603P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="212"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAB0793434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="266" mass="30452" checksum="1F67DDE76D64C8E2" modified="2020-02-26" version="1" fragment="single">ILDLSFNRIRKITKDEIGKYKRVKILYLSDNLLTNLDDSTFEDLGDLITLDLSLNAIVQPPPTLFRLPSLKRLYLSQNQNINIIDMIEQAKPISSPLELLDVSFDELKTLPDLGLLPYLLLYNISGNHLLNLKVSDIAGVCNLKVLANANFSASFQNPCDCWNFQQWLRNRDVEFTQIPCQITQENCPYNISQEDLKTFNDCKSRQEVDRKATLFVIGISAAAVIAVLALVIIGYIIYRRKRNRKFLRKKQSNILLDEKKETAGFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A867</accession>
    <name>A0A5N4A867_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_13125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A867"/>
    <dbReference type="InParanoid" id="A0A5N4A867"/>
    <dbReference type="OrthoDB" id="6759196at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23992">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.20">
        <property type="entry name" value="Pheromone/general odorant binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006170">
        <property type="entry name" value="PBP/GOBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036728">
        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01395">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024453368" evidence="1">
        <location>
            <begin position="20"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0793505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="139" mass="15987" checksum="4ECE47B46CAB2E6A" modified="2020-02-26" version="1">MICFKFVLTLLLNISLVRTLKVSDLDEHDYDCMKLLNLTVDFVMDGFNRYNFLTVGDSELNEFVSCSWSKAGYLTGGSKIDANKIKVWMHENLVKKTPDAKVTAEDLVEPCRDVTGRDSGDTVVKVYNCMMTIWWQSRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-06-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A950</accession>
    <name>A0A5N4A950_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_13398</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A950"/>
    <dbReference type="InParanoid" id="A0A5N4A950"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0793778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="108" mass="12240" checksum="4D07D4D4109F6B02" modified="2020-02-26" version="1">MLKTIRNAGEIDVKVANCMGFGNGLFFNFLIGKYTTMSLAKTRNSLNFFEIRSMALRFYQKWKEQLACVTGGKKANLCTSKKPASSEFYLLRNTYSHSRSGCLTFTQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A968</accession>
    <name>A0A5N4A968_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA polymerase delta small subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_13490</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase delta/II small subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A968"/>
    <dbReference type="FunCoup" id="A0A5N4A968">
        <property type="interactions" value="951"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A968"/>
    <dbReference type="OrthoDB" id="3763at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043625">
        <property type="term" value="C:delta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007185">
        <property type="entry name" value="DNA_pol_a/d/e_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040663">
        <property type="entry name" value="DNA_pol_D_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024826">
        <property type="entry name" value="DNA_pol_delta/II_ssu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10416">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10416:SF0">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18018">
        <property type="entry name" value="DNA_pol_D_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04042">
        <property type="entry name" value="DNA_pol_E_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA polymerase delta subunit OB-fold" evidence="4">
        <location>
            <begin position="30"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="DNA polymerase alpha/delta/epsilon subunit B" evidence="3">
        <location>
            <begin position="179"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF18018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0793870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="433" mass="48888" checksum="0C126A7664569DC7" modified="2020-02-26" version="1">MPEMSIERKCTTYRNLSDRFQKQSKDFNKQYCNIYNVRLQKMQVLLKSPILNKWGETYPVCELHKVSESEYPKCVVIGTLFKDQKLKPSVLKQLAEANSLVPQPIYTHFTDESDCLFLEDNLQRYQIYGCLQKDELVTGISMALLGSDMGNGKFNVEDYCFAGFPTQIERPILEEDLFVVFISGLDLVHIEKTSLMLRLFVNWITGLIPDVGDVSTKVVRLVIAGNSTRTVHEKIKPTIALTSRRTEMPEVIESVKLLDSLLLELVQVVDVDLMPGEHDPSNHIMPQQPMHHCMFPKSIIFKSLNQVSNPYECEVGGVQIFGNSGQPVTNVLGFCNIPTPVDVLEYFLKWSHTAPTAPDTLGCYPFYEIDPFVIESCPHVMFVSNQSTFDTKVVTGEDGQVVRLISVPEFASTSTVAVLNLKSLECYPMSFTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AB58</accession>
    <name>A0A5N4AB58_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_11404</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0794565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AB58"/>
    <dbReference type="InParanoid" id="A0A5N4AB58"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF289">
        <property type="entry name" value="DDE TNP4 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="8">
        <location>
            <begin position="74"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0794565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="250" mass="28714" checksum="03B959481B5E3EEF" modified="2020-02-26" version="1">MSQPSVSRCIKEVNEAITHFYHLIKFPTTNEEYEREKQGFMRMPNGFPGIIGAIDCTHVGIIAPPVDDVQFPAIICNSNLKILAINARFPGSVHDSGIWATSAIRRELMVKHEEGNSCWLLGDSGYPLEPWLMTPLLAPNLNEAERRYNNAHRSVRNVIERLNGVFKGRFRCLNRHRILHYSPVNAAKIINSCAVLHNLCIEREGEPYLDEQIEENPYLIDNDDEHHMNNNLLHQGRAVRNRIIRTHFMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ABW4</accession>
    <name>A0A5N4ABW4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Lipase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_11656</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0794817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ABW4"/>
    <dbReference type="FunCoup" id="A0A5N4ABW4">
        <property type="interactions" value="59"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4ABW4"/>
    <dbReference type="OrthoDB" id="8183961at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017171">
        <property type="term" value="F:serine hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013818">
        <property type="entry name" value="Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000734">
        <property type="entry name" value="TAG_lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610:SF36">
        <property type="entry name" value="LIPASE MEMBER H-A-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00151">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024361701" description="Lipase domain-containing protein" evidence="5">
        <location>
            <begin position="17"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="Lipase" evidence="6">
        <location>
            <begin position="46"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0794817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="326" mass="36734" checksum="D2263860F3BC97E8" modified="2020-02-26" version="1">MIFKLFNFFLLYRVSGALFDASWEGMGNMFDIKYWSCLLKKSYSCPDNDIKFYLYTAEEPSIQKRIDVRSNIALNAAGWDQTKNNAIIIHGFNGTHKSNPLKLLRKAYLDRGDHNVFMVEWHDLGRFPCYLSALSNLKLVSQCSAQLYAYIMNWGGMAVKTVCVGHSLGAHICGMMSNYLDVKQFKIVGLDPARPLINQFSDTTFRLSREDAYNVQVVHTNAGLLGEEGASGHVNFCINGGMLQPGCKGNAIRRSRCSHFQSVCYFAQAVIDNRMFYGKPCTLSCPKRQSWGLLPGKEVAMGLTTPLYARGQYCVQIDHDNDCVFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ACL1</accession>
    <name>A0A5N4ACL1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_04257</name>
        <name evidence="8" type="ORF">PPYR_11904</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0795065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ACL1"/>
    <dbReference type="InParanoid" id="A0A5N4ACL1"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF74">
        <property type="entry name" value="POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
        <property type="entry name" value="HTH_psq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50960">
        <property type="entry name" value="HTH_PSQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH psq-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="HTH CENPB-type" evidence="7">
        <location>
            <begin position="66"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="403"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="409"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0795065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0802071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="679" mass="76914" checksum="3081D345214DF5BA" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ACQ0</accession>
    <name>A0A5N4ACQ0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_11944</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0795105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4ACQ0"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034967">
        <property type="term" value="C:Set3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15550">
        <property type="entry name" value="PHD_MLL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10529">
        <property type="entry name" value="SET_SETD5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46462">
        <property type="entry name" value="UPSET, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46462:SF3">
        <property type="entry name" value="UPSET, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20826">
        <property type="entry name" value="PHD_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SET" evidence="6">
        <location>
            <begin position="819"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="339"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="493"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="559"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="682"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="995"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1367"/>
            <end position="1419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1560"/>
            <end position="1595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1778"/>
            <end position="1814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="339"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="497"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="522"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="724"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="735"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1025"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1086"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1159"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1172"/>
            <end position="1188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1399"/>
            <end position="1415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1579"/>
            <end position="1589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0795105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1814" mass="199330" checksum="5C377CD9A8E23206" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AEJ6</accession>
    <name>A0A5N4AEJ6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidoglycan recognition protein family domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PPYR_09802</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0795741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AEJ6"/>
    <dbReference type="FunCoup" id="A0A5N4AEJ6">
        <property type="interactions" value="53"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AEJ6"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06583">
        <property type="entry name" value="PGRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.80.10">
        <property type="entry name" value="Peptidoglycan recognition protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036505">
        <property type="entry name" value="Amidase/PGRP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002502">
        <property type="entry name" value="Amidase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015510">
        <property type="entry name" value="PGRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006619">
        <property type="entry name" value="PGRP_domain_met/bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11022">
        <property type="entry name" value="PEPTIDOGLYCAN RECOGNITION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11022:SF41">
        <property type="entry name" value="PEPTIDOGLYCAN-RECOGNITION PROTEIN LC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01510">
        <property type="entry name" value="Amidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00644">
        <property type="entry name" value="Ami_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00701">
        <property type="entry name" value="PGRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55846">
        <property type="entry name" value="N-acetylmuramoyl-L-alanine amidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0391">Immunity</keyword>
    <keyword evidence="2" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidoglycan recognition protein family" evidence="5">
        <location>
            <begin position="217"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetylmuramoyl-L-alanine amidase" evidence="4">
        <location>
            <begin position="229"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0795741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="380" mass="43165" checksum="C0E2D6620B685233" modified="2020-02-26" version="1">MILVGSQCFKNKLLRSFVCSRLTTFVLYHRYVISILLLIISPNRKSSRAFVYKQFITREVMNENNKKLCVLSQNSSNEGSASETSESGASKCEKWLERCSLNDDTHSESSCGLISNIFERADAADGDFYQNGIICNPGASILSDLQKLAKQSLPQSRPSKDYSQVMMYKCKKVLVGDVIKVDGPIYINQSAASPIQEIVTNKLFVNEVAKREEYKALNVVKRENWCMRDPIESHEYLKEPAKFVTLCSFTREGNVMLAQQLQDIHIDEKRWNDIAYNFLIGCDSRVYEGRGWGTIGAHTGGYNSKAVGIAFIGTFDNNLPTPSVLDQGKSLIKYGVDIGVIDQDYKLYAHRQIRPQSVYPGEQLFKEIQFWDHWCDHSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2024-01-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AEL3</accession>
    <name>A0A5N4AEL3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_09823</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0795762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AEL3"/>
    <dbReference type="InParanoid" id="A0A5N4AEL3"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="6"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0795762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="584" mass="68419" checksum="46769B3F82ADC4F0" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AFS5</accession>
    <name>A0A5N4AFS5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Sodium-dependent multivitamin transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PPYR_10238</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AFS5"/>
    <dbReference type="InParanoid" id="A0A5N4AFS5"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11492">
        <property type="entry name" value="SLC5sbd_NIS-SMVT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051163">
        <property type="entry name" value="Sodium:Solute_Symporter_SSF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00813">
        <property type="entry name" value="sss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985">
        <property type="entry name" value="SODIUM-COUPLED MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985:SF21">
        <property type="entry name" value="SODIUM-DEPENDENT MULTIVITAMIN TRANSPORTER-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="10" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="188"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="235"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="316"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="379"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="404"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="435"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="501"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAB0796177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="586" mass="65384" checksum="CCAABAD9A5337647" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AFY5</accession>
    <name>A0A5N4AFY5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">protein disulfide-isomerase</fullName>
            <ecNumber evidence="4">5.3.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PPYR_10321</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">1611_PpyrPB1</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 17">
            <text>Catalyzes the rearrangement of -S-S- bonds in proteins.</text>
            <dbReference type="EC" id="5.3.4.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.4.1" evidence="4"/>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AFY5"/>
    <dbReference type="InParanoid" id="A0A5N4AFY5"/>
    <dbReference type="OrthoDB" id="72053at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02961">
        <property type="entry name" value="PDI_a_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02995">
        <property type="entry name" value="PDI_a_PDI_a'_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02982">
        <property type="entry name" value="PDI_b'_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02981">
        <property type="entry name" value="PDI_b_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000107">
        <property type="entry name" value="Protein disulfide-isomerase 5-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000042">
        <property type="entry name" value="protein disulfide-isomerase A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005792">
        <property type="entry name" value="Prot_disulphide_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01130">
        <property type="entry name" value="ER_PDI_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929">
        <property type="entry name" value="PROTEIN DISULFIDE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929:SF240">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13848">
        <property type="entry name" value="Thioredoxin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10 11" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024293522" description="protein disulfide-isomerase" evidence="13">
        <location>
            <begin position="19"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="14">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="14">
        <location>
            <begin position="336"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="475"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="11">
        <location>
            <begin position="59"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="11">
        <location>
            <begin position="400"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605792-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAB0796260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="502" mass="56492" checksum="10C7518476841CB9" modified="2020-02-26" version="1">MKVISLLYLFAAILWVRCDDKGDSEIISEEYVLELKEENFDSVIESNDIVFVEFYAEQCGVCQALAPEYAKAATILAEAGSSVKLAKVDAIVETALAGKYKVDGYPTMLLFRKGTTPVSYERGRSANDIVGWLNKKSAPPAKQLQNMEEARTSIDSNDIFAIGFFADQSTDDAKMFFRVADKIDDFTMGITSDRDTFKEHAAKNGDIVIFAKYSDSPIRYEGEFNEDSLENFFSTHSLPPLVEMTNETLVPIFRGVIKTSLFIFLSKSDDNAQVIEEEVRYVATLYHTKLRFVLLNTDNQINQQIQTYLRVGRRQEPFMRIINLSGMVKFKPEHDQLTVANIKKFVEDFLDGKIGKYLASEDIPEDWNKGPVYHLVGDTFQDVAFDFEKDVLVEFYAPWCGVCKNLAPTYIEVGEHFTSNSDVIIAKLDVTVNEIPTRQISGVPTIILYKKGQNEEIEYGGPHSFEGIVKFVESGGQEGRKGEERTEDENGDGGSSSKKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AGQ0</accession>
    <name>A0A5N4AGQ0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Enoyl-CoA delta isomerase 1, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">3,2-trans-enoyl-CoA isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PPYR_10517</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">1611_PpyrPB1</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Key enzyme of fatty acid beta-oxidation. Able to isomerize both 3-cis (3Z) and 3-trans (3E) double bonds into the 2-trans (2E) form in a range of enoyl-CoA species, with a preference for (3Z)-enoyl-CoAs over (3E)-enoyl-CoAs. The catalytic efficiency of this enzyme is not affected by the fatty acyl chain length.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(2E)-tetradecenoyl-CoA = (3Z)-tetradecenoyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:29847"/>
            <dbReference type="ChEBI" id="CHEBI:61405"/>
            <dbReference type="ChEBI" id="CHEBI:61968"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="11">
            <dbReference type="Rhea" id="RHEA:29849"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(3Z)-decenoyl-CoA = (2E)-decenoyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:77195"/>
            <dbReference type="ChEBI" id="CHEBI:61406"/>
            <dbReference type="ChEBI" id="CHEBI:195601"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:77196"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(3Z)-dodecenoyl-CoA = (2E)-dodecenoyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:23716"/>
            <dbReference type="ChEBI" id="CHEBI:57330"/>
            <dbReference type="ChEBI" id="CHEBI:58543"/>
            <dbReference type="EC" id="5.3.3.8"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:23717"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(3Z)-octenoyl-CoA = (2E)-octenoyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:46044"/>
            <dbReference type="ChEBI" id="CHEBI:62242"/>
            <dbReference type="ChEBI" id="CHEBI:85640"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:46045"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AGQ0"/>
    <dbReference type="InParanoid" id="A0A5N4AGQ0"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004165">
        <property type="term" value="F:delta(3)-delta(2)-enoyl-CoA isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000034">
        <property type="entry name" value="Enoyl-CoA delta isomerase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF45">
        <property type="entry name" value="ENOYL-COA DELTA ISOMERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00051293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00052542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00056147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00068317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00083575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAB0796456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="288" mass="32111" checksum="33FF660C638AF604" modified="2020-02-26" version="1">MSSYVYKTTRRGVLLAKTVSYQVRLCSGNFRHLEVLKDENNVAIVTMKRAPVNSLNTELLTEISSVLTDLEETKCSGMILTSFSDKVFCSGLDIYEIFKSKPSAIGTSFSTLLEVFIKLYGSTFPTVAAITGHAPAGGCVLGLFCEYRIMVQNFKIGLNEDQLGFNAPSPIVKLMINTIGHRNAELALTSGRLFTTSQALQVGLVDEIAKDRTEAFEKADGFLRRFEMIPPLARNFTKQSMRRALLQDVTINREKYTEGFVSMISLHEVQQSIAAYLDNLKNKKRNAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AHB5</accession>
    <name>A0A5N4AHB5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Small nuclear ribonucleoprotein Sm D1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">snRNP core protein D1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PPYR_10737</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the snRNP core protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AHB5"/>
    <dbReference type="FunCoup" id="A0A5N4AHB5">
        <property type="interactions" value="1964"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AHB5"/>
    <dbReference type="OrthoDB" id="9626941at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01724">
        <property type="entry name" value="Sm_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000016">
        <property type="entry name" value="Small nuclear ribonucleoprotein Sm D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027141">
        <property type="entry name" value="LSm4/Sm_D1/D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034102">
        <property type="entry name" value="Sm_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23338">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7 10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="12">
        <location>
            <begin position="2"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="82"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="87"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAB0796676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="122" mass="13389" checksum="2F48A9478F74172C" modified="2020-02-26" version="1">MKLVRFLMKLSHETVSIELKNGTVIIGTITGVDVAMNTHLKAVKVTQKNQPPLTMDTITVRGNNIRYYILPDSLPLETLLIDDTPKAKAKKKDTARGATRGRGRGRGGRGGPRGRGRGRGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AJI8</accession>
    <name>A0A5N4AJI8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CHK kinase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_08447</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AJI8"/>
    <dbReference type="InParanoid" id="A0A5N4AJI8"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015897">
        <property type="entry name" value="CHK_kinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004119">
        <property type="entry name" value="EcKL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012">
        <property type="entry name" value="PROTEIN KINASE-LIKE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012:SF30">
        <property type="entry name" value="PROTEIN KINASE-LIKE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02958">
        <property type="entry name" value="EcKL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00587">
        <property type="entry name" value="CHK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHK kinase-like" evidence="1">
        <location>
            <begin position="154"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="CHK kinase-like" evidence="1">
        <location>
            <begin position="579"/>
            <end position="773"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0797453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="860" mass="100155" checksum="894F5A426AC2388A" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AK77</accession>
    <name>A0A5N4AK77_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_08733</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AK77"/>
    <dbReference type="InParanoid" id="A0A5N4AK77"/>
    <dbReference type="OrthoDB" id="6682367at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902936">
        <property type="term" value="F:phosphatidylinositol bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1200">
        <property type="entry name" value="Alpha-tocopherol transfer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.20">
        <property type="entry name" value="N-terminal domain of phosphatidylinositol transfer protein sec14p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174">
        <property type="entry name" value="ALPHA-TOCOPHEROL TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174:SF216">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00180">
        <property type="entry name" value="CRETINALDHBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="64"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0797740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="310" mass="36458" checksum="03514D8C43596321" modified="2020-02-26" version="1">MHREISPKLKEICRNDLNEVEERTETDILHIRHWLEKQTHLNFDIDNQFILAFLRCSKFSLERAKDKIDNYYTMRTLSPELYENRDPLLPEIQRLLHVGAVLPLPKVESDSNTRIIFLHLGENVDYDTMSFGNIMKLFYMVIDILLLEDDYAVIGGLKVIMQCKNSNPKYMLELTPTFIKKQALLIEKGLPFRLRAVYFMNLPALFQYLFELLKKILSSKISSRMEVFDDTKLQQLYKLTPQSALPKEWGGDNGSLGELTVTWKEKVQSYRDWFLQNEKLKSNEDLRQGPPKTYLHDFGIEGSFRQLNID</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AK97</accession>
    <name>A0A5N4AK97_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_08775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AK97"/>
    <dbReference type="InParanoid" id="A0A5N4AK97"/>
    <dbReference type="OrthoDB" id="6712302at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0797782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="273" mass="31723" checksum="E55A2B4E96063B16" modified="2020-02-26" version="1">MNCCAIKLANRTEERAISHKDEHRCLLLLLENDDNHRPSSSNEDLCDQQSEQPCLSVLNIMLPKNVKSFNTGSSTQRWANKRPRLKSAKLIQEKEPKLVDMESINVPILIEELDNDIKEEVPEEIDPDIQKLLEETHVQDGHECRMSCDDTSERAHKLKRKHRKKSKKDKEKKSKHKVKKTVSFSLSKPPTPQTEQIIRVDVVSNYSVEFETCESNRSDCVPSTPEKLSDEKHYHDTSAQFMYQLYCAQKLNETKNFYLESKKAVLFPRLNEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AMU6</accession>
    <name>A0A5N4AMU6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">MI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_09586</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic initiation factor 4G family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A5N4AMU6">
        <property type="interactions" value="1365"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AMU6"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11559">
        <property type="entry name" value="W2_eIF4G1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000042">
        <property type="entry name" value="Eukaryotic translation initiation factor 4 gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049485">
        <property type="entry name" value="eIF4G1-like_eIF4E-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003891">
        <property type="entry name" value="Initiation_fac_eIF4g_MI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003307">
        <property type="entry name" value="W2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23253">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23253:SF78">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4G1, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21140">
        <property type="entry name" value="eIF4G1-like_eIF4E-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02847">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02020">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00515">
        <property type="entry name" value="eIF5C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00544">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51366">
        <property type="entry name" value="MI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51363">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="MI" evidence="8">
        <location>
            <begin position="1108"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="domain" description="W2" evidence="7">
        <location>
            <begin position="1306"/>
            <end position="1469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="174"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="503"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="568"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="932"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1047"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="66"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="185"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="229"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="242"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="262"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="295"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="327"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="339"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="358"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="584"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="612"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="959"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1085"/>
            <end position="1102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0798593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1475" mass="165184" checksum="745BC5C0F433BA7F" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ANN3</accession>
    <name>A0A5N4ANN3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Magnesium transporter protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PPYR_06708</name>
        <name evidence="16" type="ORF">PPYR_06881</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">1611_PpyrPB1</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">1611_PpyrPB1</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Protein modification.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the OST3/OST6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0798828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ANN3"/>
    <dbReference type="FunCoup" id="A0A5N4ANN3">
        <property type="interactions" value="955"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4ANN3"/>
    <dbReference type="OrthoDB" id="67566at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015693">
        <property type="term" value="P:magnesium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000009">
        <property type="entry name" value="Tumor suppressor candidate 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021149">
        <property type="entry name" value="OligosaccharylTrfase_OST3/OST6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12692">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12692:SF0">
        <property type="entry name" value="GH11935P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04756">
        <property type="entry name" value="OST3_OST6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0732">Signal</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036147792" description="Magnesium transporter protein 1" evidence="14">
        <location>
            <begin position="23"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="263"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00043952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAB0798828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAB0799001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="327" mass="37169" checksum="E3D2470D5BD11D7C" modified="2020-02-26" version="1">MKPFILGLFFLYTIFLFYHVDGQSRKQGLSMAERVQQLTDMANKKSILKFNGNKFRDFVKAVPRNYSVVVMFTAMAPQRQCMVCRHASDEFTIVANSFRYSQAYSNKLFFAVVDFDEGSDVFQLMRLNTAPVFIHFPPKGKPKSQDTMDIQRIGFSAESIAKWITERTDIQIRLFRPPNYSGTAALVVLFALVAGFLYLRRNNLDFLYNKNMWATGALFFCFTMVSGQMWNHIRGPPFAHKNQQGQVAYIHGSSQGQFVLETYIVMVLNAAIVLGMILITESGGKGDPKKKKILAIAGVILVSVFFSLILSIFRSKTSGYPYSFLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4APL1</accession>
    <name>A0A5N4APL1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Helicase ATP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PPYR_07028</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DEAD box helicase family. DEAH subfamily. DDX11/CHL1 sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4APL1"/>
    <dbReference type="FunCoup" id="A0A5N4APL1">
        <property type="interactions" value="1558"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4APL1"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034085">
        <property type="term" value="P:establishment of sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18788">
        <property type="entry name" value="SF2_C_XPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006554">
        <property type="entry name" value="Helicase-like_DEXD_c2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010614">
        <property type="entry name" value="RAD3-like_helicase_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013020">
        <property type="entry name" value="Rad3/Chl1-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00604">
        <property type="entry name" value="rad3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472:SF41">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE DDX11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06733">
        <property type="entry name" value="DEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00488">
        <property type="entry name" value="DEXDc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="1"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAB0799148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="644" mass="71943" checksum="1FDE9FF9CD5758A4" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4APY0</accession>
    <name>A0A5N4APY0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MACPF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_07295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4APY0"/>
    <dbReference type="FunCoup" id="A0A5N4APY0">
        <property type="interactions" value="145"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4APY0"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024411042" description="MACPF domain-containing protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0799415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="246" mass="28490" checksum="528B8239FE0F8111" modified="2020-02-26" version="1" fragment="single">VPVAARMWGRALLLVLVIAFTADGEGVQESSSYDAQLKVGRSIDIFTRYGYLSLSMKVVPRNESDSNWIFREPTVDVFTDINPLIIRPQLAGKKTVFEGDFHMEFCDNLRQLLQAYFRDFTFERLQRPWRAFAASWTQDNISKYLGINSSYVHGDHCYVLVRLSRFRDTAKLSRLPNNISISEMVEREIDNVRVGDVTSVLVFMRKYGSHFINSFVTGNSLYQVRFFPLMFTFLLFSETIPDWFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AQC5</accession>
    <name>A0A5N4AQC5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">Cadherin-related tumor suppressor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">PPYR_07410</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">1611_PpyrPB1</strain>
            <tissue evidence="21">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Apical cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A5N4AQC5">
        <property type="interactions" value="165"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AQC5"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016327">
        <property type="term" value="C:apicolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050839">
        <property type="term" value="F:cell adhesion molecule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016339">
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</entry>
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            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AR96"/>
    <dbReference type="FunCoup" id="A0A5N4AR96">
        <property type="interactions" value="157"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AR96"/>
    <dbReference type="OrthoDB" id="69646at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021910">
        <property type="entry name" value="NGX6/PGAP6/MYMK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14319">
        <property type="entry name" value="FIVE-SPAN TRANSMEMBRANE PROTEIN M83"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14319:SF3">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12036">
        <property type="entry name" value="DUF3522"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024292132" description="EGF-like domain-containing protein" evidence="9">
        <location>
            <begin position="18"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="598"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="651"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="713"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="746"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="774"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="549"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="579"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0799793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="808" mass="91622" checksum="68D584E75CE458CF" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2024-11-27" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AS75</accession>
    <name>A0A5N4AS75_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_07948</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0800068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AS75"/>
    <dbReference type="InParanoid" id="A0A5N4AS75"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17352">
        <property type="entry name" value="MFS_MCT_SLC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000434">
        <property type="entry name" value="Blast:Monocarboxylate transporter 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000437">
        <property type="entry name" value="Blast:Monocarboxylate transporter 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF163">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER 9-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="436"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="459"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="493"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="534"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="3">
        <location>
            <begin position="15"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0800068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="566" mass="62714" checksum="67225EA2A3CA22FE" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ASC1</accession>
    <name>A0A5N4ASC1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">TIL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PPYR_07998</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0800118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ASC1"/>
    <dbReference type="InParanoid" id="A0A5N4ASC1"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030414">
        <property type="term" value="F:peptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19941">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036084">
        <property type="entry name" value="Ser_inhib-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051368">
        <property type="entry name" value="SerProtInhib-TIL_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002919">
        <property type="entry name" value="TIL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23259:SF70">
        <property type="entry name" value="ACCESSORY GLAND PROTEIN ACP62F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23259">
        <property type="entry name" value="RIDDLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01826">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57567">
        <property type="entry name" value="Serine protease inhibitors"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024328972" description="TIL domain-containing protein" evidence="4">
        <location>
            <begin position="18"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="domain" description="TIL" evidence="5">
        <location>
            <begin position="36"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="TIL" evidence="5">
        <location>
            <begin position="93"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="TIL" evidence="5">
        <location>
            <begin position="153"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="TIL" evidence="5">
        <location>
            <begin position="212"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="TIL" evidence="5">
        <location>
            <begin position="312"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="TIL" evidence="5">
        <location>
            <begin position="372"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="TIL" evidence="5">
        <location>
            <begin position="433"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="TIL" evidence="5">
        <location>
            <begin position="490"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="277"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0800118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="613" mass="67565" checksum="4F95FA1486999E24" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ASP5</accession>
    <name>A0A5N4ASP5_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_06076</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000004">
        <property type="protein sequence ID" value="KAB0800336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A5N4ASP5">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4ASP5"/>
    <dbReference type="OrthoDB" id="8191083at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="262"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="315"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="618"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="807"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="919"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1176"/>
            <end position="1217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1244"/>
            <end position="1267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1517"/>
            <end position="1566"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="88"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="651"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="13"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="280"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="319"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="618"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="808"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1176"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1538"/>
            <end position="1557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0800336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1566" mass="177941" checksum="B2164030F0657FF0" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ATD6</accession>
    <name>A0A5N4ATD6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">CLIP domain-containing serine protease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PPYR_06344</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000004">
        <property type="protein sequence ID" value="KAB0800604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ATD6"/>
    <dbReference type="FunCoup" id="A0A5N4ATD6">
        <property type="interactions" value="14"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4ATD6"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000146">
        <property type="entry name" value="Serine protease 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000028">
        <property type="entry name" value="Serine protease easter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022700">
        <property type="entry name" value="CLIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038565">
        <property type="entry name" value="CLIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051487">
        <property type="entry name" value="Ser/Thr_Proteases_Immune/Dev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24256">
        <property type="entry name" value="TRYPTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12032">
        <property type="entry name" value="CLIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00680">
        <property type="entry name" value="CLIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51888">
        <property type="entry name" value="CLIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024332989" description="CLIP domain-containing serine protease" evidence="11">
        <location>
            <begin position="28"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="domain" description="Clip" evidence="13">
        <location>
            <begin position="31"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="12">
        <location>
            <begin position="125"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="12">
        <location>
            <begin position="382"/>
            <end position="636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAB0800604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="637" mass="70468" checksum="ABC37E4CC35D385C" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AWA0</accession>
    <name>A0A5N4AWA0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_03783</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0801597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AWA0"/>
    <dbReference type="FunCoup" id="A0A5N4AWA0">
        <property type="interactions" value="1798"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AWA0"/>
    <dbReference type="OrthoDB" id="166134at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.20">
        <property type="entry name" value="Rabenosyn, Rab binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052727">
        <property type="entry name" value="Rab4/Rab5_effector"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021565">
        <property type="entry name" value="Rbsn_Rab-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036531">
        <property type="entry name" value="Rbsn_Rab-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510">
        <property type="entry name" value="FYVE-FINGER-CONTAINING RAB5 EFFECTOR PROTEIN RABENOSYN-5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510:SF44">
        <property type="entry name" value="RABENOSYN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11464">
        <property type="entry name" value="Rbsn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140125">
        <property type="entry name" value="Rabenosyn-5 Rab-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="16"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="6">
        <location>
            <begin position="146"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0801597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="436" mass="50441" checksum="6AD6928FAE17BF8D" modified="2020-02-26" version="1">MAMAQSPLDTDIQEGFICPVCYKDYRSSSNLFSHFVELHSEEQDLLKSIKDLVGKAKKRILKIDEKDLELFKNELSLQEFHWDYIEPQEPGVSRKHTDFFKIVRRERLDHRTSETNRLIIRLDKLLHINGSDRKQQEQELVTWLDGTAVSRCPSCAATFNITRRQHHCRLCGSVMCNLCSCFLSCDVAKMIVTNVYTDRDNSSSKVEDNIRLCTHCMNMLESRNQVQMIQGNQPLICQLYDRLQKTKIDLQESINLYEKMCNSLMSSEDTFHLKDAQSLRASIAQQAEVLDIISKQIMSISSEDNQPKLSLLKNAIRQATTRYIKEYLLVLPNPAELDKMRKNRTIKHLQAVELPKPVSLKKIAVTTGWSPENLAVQQSVTDTPNDPLEEQIKIVQNYIEQARSANRYEEVVSLEENLKFLKEAYRMNQIHSDINV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AWD9</accession>
    <name>A0A5N4AWD9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Dynein axonemal intermediate chain 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">WD repeat-containing protein 78</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PPYR_03823</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Flagellum axoneme</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Dynein axonemal particle</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0801637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AWD9"/>
    <dbReference type="InParanoid" id="A0A5N4AWD9"/>
    <dbReference type="OrthoDB" id="445052at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005858">
        <property type="term" value="C:axonemal dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120293">
        <property type="term" value="C:dynein axonemal particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045503">
        <property type="term" value="F:dynein light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003341">
        <property type="term" value="P:cilium movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050687">
        <property type="entry name" value="Dynein_IC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442:SF12">
        <property type="entry name" value="DYNEIN AXONEMAL INTERMEDIATE CHAIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442">
        <property type="entry name" value="DYNEIN INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0282">Flagellum</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 12" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="221"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="348"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAB0801637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="481" mass="53414" checksum="DE7F95A50E7D792A" modified="2020-02-26" version="1">MFSVNTSESVGFESRWKVKGVYSESSSQTSDLSVNSVSTETATSVEVDTQTSDISTPSLQPEVDNQKLSEWLIKICPLVERELNEAVYSKAFYGSYAYEESDTPNAKLLQILNVSSSSGDGDYANRVQAISWNSTGNTLAVACNYFHKSWCHHTGRVCFYTFNRDDKLPETPHKTLNINGCINTLRFHLTMPFIIACGTYSGEIVIWTVQHNDADNIVAKVKGHEEAVIDLSWVYDVGTARAILLASSSIDGLLNVWNCNLPLSTLTIKAKYKIKSPVLARLQKSTSEEISKKVVRGILAFDFSTHTHDLFVAGVEGGLLVLGSTTAANKLKGSTKEVPIFDPVMKYYEPHEGEIITVRFSPNRKDMFMSCGTDGEIRIYLTKQESPARVIFVEELYHVSWVPFHEHLITGCGKKGLLEIFHLISGQPIPNVSTDKVLPTSLLQIEVNKQRCTIVAVGNNRGELQLWSVPWGHFSSVNSVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AX30</accession>
    <name>A0A5N4AX30_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SCP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_04108</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0801922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AX30"/>
    <dbReference type="FunCoup" id="A0A5N4AX30">
        <property type="interactions" value="23"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AX30"/>
    <dbReference type="OrthoDB" id="337038at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd05382">
        <property type="entry name" value="CAP_GAPR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.33.10:FF:000010">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018244">
        <property type="entry name" value="Allrgn_V5/Tpx1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034113">
        <property type="entry name" value="SCP_GAPR1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01010">
        <property type="entry name" value="CRISP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024439414" description="SCP domain-containing protein" evidence="3">
        <location>
            <begin position="21"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="4">
        <location>
            <begin position="21"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0801922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="169" mass="19098" checksum="DF34EBADD27E83A1" modified="2020-02-26" version="1">MQAALVLLFLVGASLVAVLGDRRLNIAVLNAHNRYRAQHGVPPLTLDSRLNNFAQDWANHLAETDTFSHRPDNPYGENLFWSSVYKQTNQEIALTAVEVWYNESQKYDYNTNDGIEGTYHFTQLIWKSSRKLGVGVAKSSKNIVYVACNYDPIGNVQGQFIENVPRPLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AX44</accession>
    <name>A0A5N4AX44_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_04039</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0801853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AX44"/>
    <dbReference type="InParanoid" id="A0A5N4AX44"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="278"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0801853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="471" mass="54603" checksum="0510B5D0C51D355B" modified="2020-02-26" version="1">MPSELEKLTEQLANAFTTYRSEQSEIIDEIENPEIMAQAQPKTVNYSLLKLYVETIPNFDGNPHTLGIFTDNCENLILNFYDPVNETLNNFMLRAIISKLTGRALSLIGSRIELRTWNEIKNALNLSFGDQRNIDCLVQDLIILRPNKNETPYNFGMRCQDARSLIISKLNSSDLTIPEKTLKLKNYDELALKTFIRGLSGQIQNNVRLRNPENLEKAMSLLIEEENFLYSQNRGNLLNTQSMYKPTQRITPSNQSPYKSPFQNNNSHVGPTNNHWRPPTSSFQPQFQPYQNFQLPRQNNLQTTTPRPPMQNSQINWKQNNPFPTQKLPYFSQRPSQISRNPYLNKSNHQNQPNTNYQPEPMDTSSGNTKTQPRKNFTSNELFLQDTNNSENFYDQQLNHPDQYSIYDHPENSHNDFYDSHATSSFVEEDNEPQYHVTADDNDYNNLPGNYIAEELSHDNFYQASHSENPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AXM1</accession>
    <name>A0A5N4AXM1_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_04252</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AXM1"/>
    <dbReference type="InParanoid" id="A0A5N4AXM1"/>
    <dbReference type="OrthoDB" id="7665616at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23992">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.20">
        <property type="entry name" value="Pheromone/general odorant binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006170">
        <property type="entry name" value="PBP/GOBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036728">
        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01395">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024313775" evidence="1">
        <location>
            <begin position="17"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0802066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="145" mass="15920" checksum="37721879C5A0E32E" modified="2020-02-26" version="1">MKTLVVIACLCAFAVAQEDGDKKDTIFKILKDCAKKEGIDRGNIKKVIESGAFNDEKFQLFAQCFVKEIGALTSDGTVNWNYIREKCKSYTQDCAFVDECSTKTGSNQAETNASGAACLIVNIHKKMKEMKKNNKDECGEGGCPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AXT5</accession>
    <name>A0A5N4AXT5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHamide-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_04244</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AXT5"/>
    <dbReference type="InParanoid" id="A0A5N4AXT5"/>
    <dbReference type="OrthoDB" id="6367990at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0802058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="158" mass="17646" checksum="C46950F73737AE77" modified="2020-02-26" version="1">MIIMCQLLKLKYTAMTGKVAAISVILIFCFAECAAGSCLSYGHSCWGGHGKRSDTSNGDTKDSSVDSISDTKWALSRLLQPSFDVRKWKAQNDVAVPKHSNLENIKSALQDDIDSDTLDTMAINDDSLYVDEQPSSRHRTAEDRMRLYKLIKNINRLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AYE6</accession>
    <name>A0A5N4AYE6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_04545</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AYE6"/>
    <dbReference type="InParanoid" id="A0A5N4AYE6"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF267">
        <property type="entry name" value="NUCLEASE HARBI1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="8">
        <location>
            <begin position="143"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0802359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="357" mass="40804" checksum="772022FB8A7A8265" modified="2020-02-26" version="1">MDNPAFILLINALEHVEEINQQRLYRRQLRDASDPLSLPETTFKNMYRISRQMAHGLIVDLDPHLHDTRRNVLYIPKNLKILAALQFYAHGSYQKVVGIYEVNVALENFYHLIHFPSTPEECAVEKQRFMSLPNGFPGIIGAIDCTHVAIIAPPHEDPHYPGMVFLNRKGYCSINVQIICNANLRILAINSRFPGSVHDSAIWSTSLIRRHLIAMHDEGNQNSWLIGDSGYPLEPWLLTPVAGINLTDPERRYNMGHKSVRNVIERLNGVLKGRFRCLGRARMLHYSPPVAAKIINSCAVLHNLCVDRGEIDVEEEIDENMGDDIPCDIHNENYGDNNVLIRGRNIRNRVIRNHFMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AZ32</accession>
    <name>A0A5N4AZ32_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_04729</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AZ32"/>
    <dbReference type="InParanoid" id="A0A5N4AZ32"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1820">
        <property type="entry name" value="L1 transposable element, RRM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004244">
        <property type="entry name" value="Transposase_22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11505">
        <property type="entry name" value="L1 TRANSPOSABLE ELEMENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0802543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="215" mass="24703" checksum="0B7808287361050A" modified="2020-02-26" version="1">MPQTRARQQSQDRPDYNYVDNVEPKNSDIIKLLIELKESHKCSEESLITSLNLCHSKLDDNAKELAKINTRIDSHDDLIQSLQQENHQFRKSLSVQKLKTDELEQYTRRNNIEVHGIPQIQGEDVYQLIQKVAVALGVNVDKGGIDTCHRISKSSSSSVIICKFVNRYTKEEMLAKRKIKRNLSTTDIGFSRGSTIYINENLTVYRRQLPTLQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AZX6</accession>
    <name>A0A5N4AZX6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PPYR_05070</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GLI C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AZX6"/>
    <dbReference type="InParanoid" id="A0A5N4AZX6"/>
    <dbReference type="OrthoDB" id="3214149at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000310">
        <property type="entry name" value="GLIS family zinc finger 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000359">
        <property type="entry name" value="GLIS family zinc finger 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043359">
        <property type="entry name" value="GLI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056436">
        <property type="entry name" value="Znf-C2H2_ZIC1-5/GLI1-3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45718:SF8">
        <property type="entry name" value="GLIS FAMILY ZINC FINGER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45718">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR CUBITUS INTERRUPTUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23561">
        <property type="entry name" value="zf-C2H2_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="86"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="125"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="153"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="181"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="211"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAB0802884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="343" mass="38995" checksum="22F260EBF25582DE" modified="2020-02-26" version="1">MIVYNHRMLEGDPLQYYTTGLSIPAQPSYFSYFNRFQSYDHLNMSEELLMPHSPNGSQSDSDNSISSLEPFPKDSKLSIIKKSEQVQCCWSSCGIIFESLDQLAIHVSRVHSASGPGGLFYCGWKGCTRNNKGFNARYKMLVHVRTHTNEKPHHCYQCDKSFSRAENLKIHSRSHSGEKPYVCPVPGCHKAYSNSSDRFKHTRTHQVDKPYQCKVPGCPKRYTDPSSLRKHVKTYKHFVSENGVSAVNIKTSVIVTNKKVESHLGAINESCDSLCTCKHLCCASKDSGVLKLDGYINIRNNHNTSTWNKTAFIPEPKLFRPYQIDDKMEIDLPLDLSIARRHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B0U4</accession>
    <name>A0A5N4B0U4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PPYR_00108</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B0U4"/>
    <dbReference type="FunCoup" id="A0A5N4B0U4">
        <property type="interactions" value="78"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4B0U4"/>
    <dbReference type="OrthoDB" id="10059102at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000077">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050430">
        <property type="entry name" value="Peptidase_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276:SF91">
        <property type="entry name" value="AT26814P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276">
        <property type="entry name" value="POLYSERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024450242" description="Peptidase S1 domain-containing protein" evidence="9">
        <location>
            <begin position="17"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="10">
        <location>
            <begin position="31"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0803138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="250" mass="26161" checksum="0EBB08816BCF3182" modified="2020-02-26" version="1">MFRLLLLLTVVTLAAGAKLQRASPPRLDGKIVGGKPVKIEDYPYQVSLQYYGSHICGGSIIGPNKVLTAAHCTSGSSASSLSIRHSSTYKGSEGVVIKVASIAQNPAYNPSTISDDVTVLTLAEPIKDSDIGKPIAMVEANATEGDREAVCTGWGSLSSGGSSPRQLQAVDVKEVDRKECNRSYGGGITDTMICFGSPGKDSCQGDSGGPLVVGDKQVGIVSWGYGCAHPEYPGVYAHVAPLRTFIDQNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B1F0</accession>
    <name>A0A5N4B1F0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ran-binding protein 9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_00399</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RANBP9/10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B1F0"/>
    <dbReference type="InParanoid" id="A0A5N4B1F0"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013144">
        <property type="entry name" value="CRA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08513">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00757">
        <property type="entry name" value="CRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="2">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="CTLH" evidence="3">
        <location>
            <begin position="174"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0803429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="480" mass="53170" checksum="CA21B4F709FD52B6" modified="2020-02-26" version="1">MGIGLSAQGVNMNRLPGWDKQSYGYHGDDGHSFCSSGTGQPYGPTFTTGDVIGCGVNLIDNSCFYTKNGHNLGTAFTELPPNLYPTVGLQTPGEVVDANFGQEPFVFDIEDMMNELRSKTRLSIYDYPVYEDQGEWQAILNKMVSTYLVHHGYCNTAEAFAHITNQPFNEDIGSIKNRQRILKLVLAGRMGEAIERTSRLYPGLLEHNQNLLFMLKCRQFVEMVNGSDVEVCPRRNIGGFSPSYNLSPRPNSPIQTSVIQSTKNYSNNKTKPTVEELNQNNAAMNGSSNIPVIRTTDDSDVEMDTAEEIQNGHADNSCNGKLITNSSNGYQNGNGHSNICSNDRFEEEDEEDMDVDTALRKSCKPAVERILEFGRELYSMSQRLKVEQGSSEHNEKMLEDAFSLLAYSNPWASPVGWQLDHAQRESVCASLNSAILESQNKPRKPPLEVAMAHAQELVRLMSSSGLGSCAFASVSDLMEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B1Q1</accession>
    <name>A0A5N4B1Q1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">tRNA selenocysteine-associated protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PPYR_00453</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RRM TRSPAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B1Q1"/>
    <dbReference type="FunCoup" id="A0A5N4B1Q1">
        <property type="interactions" value="1599"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4B1Q1"/>
    <dbReference type="OrthoDB" id="446113at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12610">
        <property type="entry name" value="RRM1_SECp43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12345">
        <property type="entry name" value="RRM2_SECp43_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000159">
        <property type="entry name" value="tRNA selenocysteine 1-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000166">
        <property type="entry name" value="Trna selenocysteine 1-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040434">
        <property type="entry name" value="TSAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041085">
        <property type="entry name" value="TSAP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37457">
        <property type="entry name" value="TRNA SELENOCYSTEINE 1-ASSOCIATED PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37457:SF3">
        <property type="entry name" value="TRNA SELENOCYSTEINE-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17654">
        <property type="entry name" value="Trnau1ap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 10" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="7"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="100"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAB0803483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="294" mass="32861" checksum="85FCF88F7B461514" modified="2020-02-26" version="1">MASMVHCQLWMGSLEPYMTETFISTAFRKMGENPLNVKVMRNKFTGEPAGYCFVHFATDEEAIDAMHKLNGKPISGTNPVVRFRLNNASNTGRNLVDREFSVWVGDLSPDVDDYNLYRIFSSKYNTIKTAKVILDNSGFSKGYGFVRFGSEEEMKDALMNMNGFVGLGSKALKICNAVPKPKGAITTTGNGTTPTNTLSTASTDYSQYYDATYWQNYANWQSGYYDQGDGSQSDAYADANAHGEGREEDELELIEHSLPLDVDKVNRETMDQDSALWDALESSKWIPCDIVETY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B2N8</accession>
    <name>A0A5N4B2N8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PPYR_00758</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4B2N8"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.70:FF:000003">
        <property type="entry name" value="Protein CBG25708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000063">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005162">
        <property type="entry name" value="Retrotrans_gag_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13975">
        <property type="entry name" value="gag-asp_proteas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03732">
        <property type="entry name" value="Retrotrans_gag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="9">
        <location>
            <begin position="489"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="10">
        <location>
            <begin position="1024"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1301"/>
            <end position="1349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1301"/>
            <end position="1314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0803788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1370" mass="156786" checksum="46EE0FE7F44CC1B2" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B2Q5</accession>
    <name>A0A5N4B2Q5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA replication licensing factor MCM4</fullName>
            <ecNumber evidence="11">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PPYR_00816</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the MCM2-7 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the MCM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="11"/>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B2Q5"/>
    <dbReference type="FunCoup" id="A0A5N4B2Q5">
        <property type="interactions" value="1206"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4B2Q5"/>
    <dbReference type="OrthoDB" id="10251574at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17755">
        <property type="entry name" value="MCM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000003">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1640.10:FF:000001">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000217">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008047">
        <property type="entry name" value="MCM_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF66">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21128">
        <property type="entry name" value="WHD_MCM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01660">
        <property type="entry name" value="MCMPROTEIN4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 11" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="13">
        <location>
            <begin position="502"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="102"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="130"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAB0803846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="912" mass="102411" checksum="02DB40B0AA31B1A9" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B316</accession>
    <name>A0A5N4B316_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_00760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B316"/>
    <dbReference type="InParanoid" id="A0A5N4B316"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37162:SF1">
        <property type="entry name" value="BED-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37162">
        <property type="entry name" value="HAT FAMILY DIMERISATION DOMAINCONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0803790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="508" mass="57880" checksum="D4F8B0C75E77919D" modified="2020-02-26" version="1">MKTRIYQYQDNHNPLEMYTNTELLQRVRFSRHTITDILLPMVYPQGQHENNRGLPVPPILKLYLALRFFATGSYQRVCGDLLSVSQSSVSRIIHEVSEQLTRHLARYIKFPNNNVDFTNIKNSFFAIAEFPGVIGCVDGTHIEIKSPGGPNAEVYRNQLKMPKPQYEQKFRHAWLKDPILKDWLVAVESTAGTTGKCRVCNIVVTSRYADLKNHGASMRHKKNAKLILGPHPQPQLKFPGESEMFAAKQAELKLSLFVAQHTSVRVVDHLVNTCKKTFEGQSSTHIKMHRTKCSGIIQNIIAPHFFNDLKNDIGDSKFSLLLDESTDITVRKYLGMIILYFSERENKLVTTYLDLAVLDNCDADGLLHTIKTTLNKYSLNLQNLIGIGTDNTSVMTGANNGLYVKLKEEVPELLLIRCVCHSLQLAVTHASKETLPRNIEFIIQETYKWFSKSSSRQCAYNDIYSTMNEGHNPLKIVRACQTRWLSIESAVSRIINQWDALKLHFQLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B377</accession>
    <name>A0A5N4B377_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Galectin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PPYR_00973</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B377"/>
    <dbReference type="InParanoid" id="A0A5N4B377"/>
    <dbReference type="OrthoDB" id="6251307at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016936">
        <property type="term" value="F:galactoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00070">
        <property type="entry name" value="GLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000124">
        <property type="entry name" value="Galectin-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044156">
        <property type="entry name" value="Galectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001079">
        <property type="entry name" value="Galectin_CRD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11346:SF176">
        <property type="entry name" value="32 KDA BETA-GALACTOSIDE-BINDING LECTIN LEC-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11346">
        <property type="entry name" value="GALECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00337">
        <property type="entry name" value="Gal-bind_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00908">
        <property type="entry name" value="Gal-bind_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00276">
        <property type="entry name" value="GLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51304">
        <property type="entry name" value="GALECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0430">Lectin</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Galectin" evidence="5">
        <location>
            <begin position="12"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="144"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="230"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="145"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="165"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="241"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="256"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="272"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU102079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0804003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="332" mass="34966" checksum="90DA6DA3B90F49F7" modified="2020-02-26" version="1">MVQVINNPAVPFVGPIKGGLDPGSMIRIQGAVPENADKFNVNLHCGRPPSDVALHISVRLLQGYIARNSLQDDDWGEEEGDGNLTIGSGQSFEILILCDPSSYKIAVNGRHFCEFRHRIPFNGVSHLEIEGTVELQLIAIESALPAPPPPRQPPPNADFSSGYNMPPPPGNYGQGPPPQGPYGGGPGYYPHHPPGNKQEESGLDSIFGNAGAAIAGVVVSGLAENFLSGLSGGGGQSNNTQQHPPMQPQQPHYQGAPQSHGQQSSNIMGDILGSLASELAGGGAQSRHPQQPMHPQQPPYQGGPQPQGQQSSIVGDLLGNLASEIFKPSRRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B3I7</accession>
    <name>A0A5N4B3I7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_01151</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B3I7"/>
    <dbReference type="InParanoid" id="A0A5N4B3I7"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990837">
        <property type="term" value="F:sequence-specific double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007417">
        <property type="term" value="P:central nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048812">
        <property type="term" value="P:neuron projection morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000357">
        <property type="entry name" value="Motor neuron and pancreas homeobox 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042768">
        <property type="entry name" value="MNX1/Ceh-12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24335:SF4">
        <property type="entry name" value="EXTRA-EXTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24335">
        <property type="entry name" value="MOTOR NEURON AND PANCREAS HOMEOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="170"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="172"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="45"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="231"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="57"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="233"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="252"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="278"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0804181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="293" mass="33295" checksum="400539E4B2F56811" modified="2020-02-26" version="1">MSHYINEAAHILHAHPDSSYHQSKPLNMDTKLQESKGSFCIDALLSRNDDRPNTPDTSRSISPSSTRSRSPPISPGSEEIPPTSFVPRPGLLNHIYPNGGLYGYQSQHHVQSSAFHTLDGSMVQKLQIPINHHSPSQLQQMQLEWLARTGMFYQRLPDLTGCAPGHAILGKTRRPRTAFTSQQLLELEKQFRQNKYLSRPKRFEVATSLMLTETQVKIWFQNRRMKWKRSKKAQQEAKIGKDDNVSEKRQLSTSSSVTKPSSSSSQDVTDPVPSTQTESRRIQDESLYRPYVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B3P4</accession>
    <name>A0A5N4B3P4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cytosolic beta-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.21</ecNumber>
            <ecNumber evidence="2">3.2.1.46</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Cytosolic galactosylceramidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Cytosolic glucosylceramidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Cytosolic glycosylceramidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PPYR_01143</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">1611_PpyrPB1</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a beta-D-galactosyl-(1&lt;-&gt;1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-galactose</text>
            <dbReference type="Rhea" id="RHEA:14297"/>
            <dbReference type="ChEBI" id="CHEBI:4139"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18390"/>
            <dbReference type="ChEBI" id="CHEBI:52639"/>
            <dbReference type="EC" id="3.2.1.46"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:14298"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a beta-D-xylosyl-(1&lt;-&gt;1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-xyloside + an N-acylsphing-4-enine</text>
            <dbReference type="Rhea" id="RHEA:70239"/>
            <dbReference type="ChEBI" id="CHEBI:16113"/>
            <dbReference type="ChEBI" id="CHEBI:52639"/>
            <dbReference type="ChEBI" id="CHEBI:189067"/>
            <dbReference type="ChEBI" id="CHEBI:189068"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:70240"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="9">
            <dbReference type="Rhea" id="RHEA:70241"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>beta-D-galactosyl-(1&lt;-&gt;1')-N-octadecanoylsphing-4-enine + H2O = N-octadecanoylsphing-4-enine + D-galactose</text>
            <dbReference type="Rhea" id="RHEA:59292"/>
            <dbReference type="ChEBI" id="CHEBI:4139"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:72961"/>
            <dbReference type="ChEBI" id="CHEBI:84720"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:59293"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>beta-D-galactosyl-(1&lt;-&gt;1)-sphing-4-enine + H2O = sphing-4-enine + D-galactose</text>
            <dbReference type="Rhea" id="RHEA:43908"/>
            <dbReference type="ChEBI" id="CHEBI:4139"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57756"/>
            <dbReference type="ChEBI" id="CHEBI:57934"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:43909"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>beta-D-glucosyl-(1&lt;-&gt;1)-N-octadecanoylsphing-4-enine + H2O = N-octadecanoylsphing-4-enine + D-glucose</text>
            <dbReference type="Rhea" id="RHEA:59284"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:72961"/>
            <dbReference type="ChEBI" id="CHEBI:84719"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:59285"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>beta-D-glucosyl-(1&lt;-&gt;1)-sphing-4-enine + H2O = sphing-4-enine + D-glucose</text>
            <dbReference type="Rhea" id="RHEA:59288"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57756"/>
            <dbReference type="ChEBI" id="CHEBI:83992"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:59289"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the glycosyl hydrolase 1 family. Klotho subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="3"/>
    <dbReference type="EC" id="3.2.1.46" evidence="2"/>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B3P4"/>
    <dbReference type="InParanoid" id="A0A5N4B3P4"/>
    <dbReference type="OrthoDB" id="65569at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004336">
        <property type="term" value="F:galactosylceramidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000011">
        <property type="entry name" value="Cytosolic beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353:SF36">
        <property type="entry name" value="LP05116P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024305872" description="Cytosolic beta-glucosidase" evidence="17">
        <location>
            <begin position="19"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00050809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00052085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00060858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00068094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00079026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00081896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00083229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAB0804173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="488" mass="55658" checksum="2DFA29B959BD42D1" modified="2020-02-26" version="1">MFWKITLLVVASIQITFCQNVSGIMLPTQLLMGAGTSAYQVEGAWNEDGRGLSIWDTFVHDYPEKIEDHSTGDVASDTYHKTKEDVALLKNIGFHFYRFSISWSRVLPKGFENEVNPLGIAYYNTLIDELLANGIEPVVTMYHFDLPQTLQDLGGWTNPNIIKWFTNFARILFENFGNRVKSWITINEPKQLCRFTYAKGLIAPGLVSEGLGEYLCIHYATLAHASVYHLYSRRFRRSQNGKVGLTIDGSWCEPVDKKERDAASRKIAFDIDMFANPIFGQLGGYPDFISKFIGYKSKLEGYTESRLPKLSPEQISYIKGTADFFGLNFYYTTLAKSGPSTLLNTKDMDVEDLPEPNPIKNVNESIKLAAIGFRKVLRYVKTKYGNPEIWILENGFPTTEDSGLDDQSRISYFKNSIRSVVDAINKDKVNIRRYTVWSIMDNFEWNKGYTVRFGIFHINFTDPSRERVPKASATFFKTLLATRTLPTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B3P6</accession>
    <name>A0A5N4B3P6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_01128</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B3P6"/>
    <dbReference type="InParanoid" id="A0A5N4B3P6"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF269">
        <property type="entry name" value="NUCLEASE HARBI1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="8">
        <location>
            <begin position="17"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0804158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="163" mass="18958" checksum="6C97FFC1B9B97048" modified="2020-02-26" version="1" fragment="single">LIDKPPLDDSDTLVPFVLVGDDAYPLKTFIMKPFGHKKMTDAQRIFNYRLSRCRRCVECAFGILTAKWRLLNKAIETEVEKAEKIIKCMCLLHNLIIDKDNITLNQRVIEDAVQEYQEQHETPHLGGRRFNRSSTAAQEVRNFYKDYFNGSGSALWQNQMVFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B3P8</accession>
    <name>A0A5N4B3P8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_00970</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B3P8"/>
    <dbReference type="InParanoid" id="A0A5N4B3P8"/>
    <dbReference type="OrthoDB" id="6343941at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000437">
        <property type="entry name" value="Beat-IIIc, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21261">
        <property type="entry name" value="BEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21261:SF15">
        <property type="entry name" value="BEATEN PATH IIIA, ISOFORM D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024386521" description="Ig-like domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="38"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0804000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="282" mass="31748" checksum="CF0B669FAA000DBB" modified="2020-02-26" version="1">MEIFRTLGFILLLDIVFINDSKALKDVSVIVPQAVVVGDSVSLHCRFNLEGEPLYTVKWYKGQSEFYRYLPKELPNTQVFPLSGIAVDLSNSSPNQVVLRDVQTISTGRYRCEVSTDAPNFFTNIETGYMYVIKMPSGTPQIKIEKDSYEVGYTLSGNCSSPPAYPHFNLTWFINDKMVNATSVMYLPDPNASESQRMPKITVARFELEIDANTFYEGKVRLQCLASLFNIYQSQTEVILEEERPKPRPSSVLGTRSNVAGLVTNSRRACLMSIVLLGLILR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B3Q0</accession>
    <name>A0A5N4B3Q0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Luciferin 4-monooxygenase</fullName>
            <ecNumber evidence="4">1.13.12.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PPYR_01207</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">1611_PpyrPB1</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>firefly D-luciferin + ATP + O2 = firefly oxyluciferin + hnu + AMP + CO2 + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:10732"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16792"/>
            <dbReference type="ChEBI" id="CHEBI:30212"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58038"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="1.13.12.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.12.7" evidence="4"/>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B3Q0"/>
    <dbReference type="FunCoup" id="A0A5N4B3Q0">
        <property type="interactions" value="312"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4B3Q0"/>
    <dbReference type="OrthoDB" id="10253869at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047077">
        <property type="term" value="F:Photinus-luciferin 4-monooxygenase (ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008218">
        <property type="term" value="P:bioluminescence"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000007">
        <property type="entry name" value="4-coumarate--CoA ligase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.38.10">
        <property type="entry name" value="Luciferase, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF423">
        <property type="entry name" value="GM05240P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0455">Luminescence</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="14" id="KW-0599">Photoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="16">
        <location>
            <begin position="36"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="17">
        <location>
            <begin position="451"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAB0804237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="543" mass="60476" checksum="45024CF1411BA7A7" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B3W7</accession>
    <name>A0A5N4B3W7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">beta-mannosidase</fullName>
            <ecNumber evidence="4">3.2.1.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Mannanase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PPYR_01214</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides.</text>
            <dbReference type="EC" id="3.2.1.25"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Lysosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.25" evidence="4"/>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B3W7"/>
    <dbReference type="FunCoup" id="A0A5N4B3W7">
        <property type="interactions" value="535"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4B3W7"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004567">
        <property type="term" value="F:beta-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000050">
        <property type="entry name" value="Beta-mannosidase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000060">
        <property type="entry name" value="Probable beta-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054593">
        <property type="entry name" value="Beta-mannosidase-like_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050887">
        <property type="entry name" value="Beta-mannosidase_GH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Ig-like_GH2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43730">
        <property type="entry name" value="BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43730:SF1">
        <property type="entry name" value="BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22666">
        <property type="entry name" value="Glyco_hydro_2_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="beta-Galactosidase/glucuronidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0458">Lysosome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024361704" description="beta-mannosidase" evidence="11">
        <location>
            <begin position="21"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-mannosidase-like galactose-binding" evidence="13">
        <location>
            <begin position="30"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich" evidence="12">
        <location>
            <begin position="218"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF22666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAB0804244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="663" mass="76757" checksum="F0C7F3E51173658C" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-06-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B3Z7</accession>
    <name>A0A5N4B3Z7_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_01285</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B3Z7"/>
    <dbReference type="InParanoid" id="A0A5N4B3Z7"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0804315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="173" mass="19390" checksum="FB0BBF4574816958" modified="2020-02-26" version="1">MDENERLLKTAINLHYHDRPNILLTASQIIQEYCNGEQTCDKYCEVLQKLRDLMSDLPETILLYFLTTIPDSDLIDDASPPPLIGLMKQIRLRLIESIKSVLSEYITNAISPLNPIKQTESSLEQGNELEGEILKSDDGQFGNVENRAVDDNGVVEIMDSESCGMCTDLLASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B6E0</accession>
    <name>A0A5N4B6E0_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_02094</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0805124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B6E0"/>
    <dbReference type="InParanoid" id="A0A5N4B6E0"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33053">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33053:SF24">
        <property type="entry name" value="TRANSPOSASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0805124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="602" mass="68347" checksum="91851A679BC9D965" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B6V2</accession>
    <name>A0A5N4B6V2_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Putative nuclease HARBI1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Harbinger transposase-derived nuclease</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PPYR_02295</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Transposase-derived protein that may have nuclease activity. Does not have transposase activity.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HARBI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0805325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B6V2"/>
    <dbReference type="InParanoid" id="A0A5N4B6V2"/>
    <dbReference type="OrthoDB" id="2668416at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026103">
        <property type="entry name" value="HARBI1_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF85">
        <property type="entry name" value="GH03217P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02086">
        <property type="entry name" value="PUTNUCHARBI1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="13">
        <location>
            <begin position="175"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAB0805325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="373" mass="42827" checksum="4E59769D1C390E0E" modified="2020-02-26" version="1">MDNLKRNVIIGVLNEVLDDDSDDELIAIVCSSYNSIERKSRVCIRNYVENIVRAYSFDDFKSHFRISRITFENLVQVLGPSLKERNVQGIGRHCHSPDLQLLVSLTMFSNQTVYRLLSDKFDISKSTAWLYVRKVTEALKEVSSIYISWPTGATANNISEKFKERQNFPGVIGAIDGCHILITPPRNVQGSYCNRKGQHSIILQGVCDANYMFLDVFAGFPGSVHDARVFYNSPLGTKMRENPGELFPNNTHILGDSAYKCSNYLLTPYRDNGHLSRKQKNYNFKHSSTRVYVEQTFGLLKGRFRILKHVHMYNVELIPDLILACCVLHNICMKNNDEIDVDTFEDKDDYYNNGDEDFRKVGKREYIADLLMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B7D4</accession>
    <name>A0A5N4B7D4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Non-specific protein-tyrosine kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PPYR_02230</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0805260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B7D4"/>
    <dbReference type="FunCoup" id="A0A5N4B7D4">
        <property type="interactions" value="636"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4B7D4"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005126">
        <property type="term" value="F:cytokine receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007259">
        <property type="term" value="P:cell surface receptor signaling pathway via JAK-STAT"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019221">
        <property type="term" value="P:cytokine-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002009">
        <property type="term" value="P:morphogenesis of an epithelium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041155">
        <property type="entry name" value="FERM_F1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051286">
        <property type="entry name" value="JAK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041381">
        <property type="entry name" value="JAK1-3/TYK2_PHL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45807">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE HOPSCOTCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45807:SF7">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE HOPSCOTCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18379">
        <property type="entry name" value="FERM_F1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17887">
        <property type="entry name" value="Jak1_Phl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21990">
        <property type="entry name" value="SH2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="FERM" evidence="9">
        <location>
            <begin position="4"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="690"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="726"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0805260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="857" mass="97476" checksum="0B98EBD87E8AC7CA" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-09-13" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B811</accession>
    <name>A0A5N4B811_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4218 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_02648</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0805678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B811"/>
    <dbReference type="InParanoid" id="A0A5N4B811"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33053:SF9">
        <property type="entry name" value="AGAP000105-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33053">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0805678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="530" mass="61019" checksum="E349FA88F982B5EC" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1JU32</accession>
    <name>A0A1Y1JU32_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AN1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_10622</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01100677">
        <property type="protein sequence ID" value="JAV52824.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1JU32"/>
    <dbReference type="FunCoup" id="A0A1Y1JU32">
        <property type="interactions" value="15"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1JU32"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1110.10">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035896">
        <property type="entry name" value="AN1-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000058">
        <property type="entry name" value="Znf_AN1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01428">
        <property type="entry name" value="zf-AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00154">
        <property type="entry name" value="ZnF_AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118310">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51039">
        <property type="entry name" value="ZF_AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="AN1-type" evidence="5">
        <location>
            <begin position="36"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="JAV52824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0796561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="130" mass="14749" checksum="6DFBFD5AF05EB208" modified="2017-08-30" version="1">MSTITKTVESKLKNKEKNLKKATDSNDLDTVLDNVKKIDATCCFTKCKKRTSDFGIDCKYCSSRFCTAHGLPEIHGCGEAVRRDEQRKFQHPYTALSQDKHGKAADKLAVKLKQMQFERKAKQCTSKSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1JUR3</accession>
    <name>A0A1Y1JUR3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ferritin</fullName>
            <ecNumber evidence="6">1.16.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_07319</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>4 Fe(2+) + O2 + 4 H(+) = 4 Fe(3+) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11148"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.16.3.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ferritin family.</text>
    </comment>
    <dbReference type="EC" id="1.16.3.1" evidence="6"/>
    <dbReference type="EMBL" id="GEZM01100584">
        <property type="protein sequence ID" value="JAV52843.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1JUR3"/>
    <dbReference type="InParanoid" id="A0A1Y1JUR3"/>
    <dbReference type="OrthoDB" id="186462at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004322">
        <property type="term" value="F:ferroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01056">
        <property type="entry name" value="Euk_Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001519">
        <property type="entry name" value="Ferritin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009040">
        <property type="entry name" value="Ferritin-like_diiron"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008331">
        <property type="entry name" value="Ferritin_DPS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11431">
        <property type="entry name" value="FERRITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11431:SF75">
        <property type="entry name" value="FERRITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00210">
        <property type="entry name" value="Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50905">
        <property type="entry name" value="FERRITIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="2 6" id="KW-0409">Iron storage</keyword>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ferritin-like diiron" evidence="7">
        <location>
            <begin position="56"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601519-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="JAV52843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0799439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="250" mass="28430" checksum="035233B1A9863172" modified="2017-08-30" version="1">MNLFKFPKFSLLKPKNAPNDLSWKIFKYISTITFPADYSHPHFFSSKASAGSIGRSSYHAEVEKAVNEQIVAEFNAMYMYLSMASYFGRTDVALPGCYGFFMDMHIEEHEHGLIFLNYQNMRGGKVVLGNIQLAPDKICWDGIRSAFATAAEMEKSIKDKLLAVNCVAEKHRDYGVIDLITSYFIPAQDRSICEMSRLLQRITKMGKEGVAEYLFDKEVHTAFVQKGPKPYIPDYPNAEKDAANKKDLYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1JYL7</accession>
    <name>A0A1Y1JYL7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peroxisomal biogenesis factor 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Peroxisomal assembly protein PEX3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_14427</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in peroxisome biosynthesis and integrity. Assembles membrane vesicles before the matrix proteins are translocated. As a docking factor for PEX19, is necessary for the import of peroxisomal membrane proteins in the peroxisomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts with PEX19.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01103135">
        <property type="protein sequence ID" value="JAV51537.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1JYL7"/>
    <dbReference type="FunCoup" id="A0A1Y1JYL7">
        <property type="interactions" value="2076"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1JYL7"/>
    <dbReference type="OrthoDB" id="45930at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045046">
        <property type="term" value="P:protein import into peroxisome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006966">
        <property type="entry name" value="Peroxin-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28080">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28080:SF1">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04882">
        <property type="entry name" value="Peroxin-3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="JAV51537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0792468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="342" mass="39072" checksum="DD71E9EF3FAB74AD" modified="2017-08-30" version="1">MGVFSKLGAFLNRHRNKFFVGGVLVSGSILLTRYAQHRLQEWQQNEAKEFFERTRKQQHYESTERTCNQTILNLINPLSESLMKATADIDEILAELRVNPANKLELWERLKVLVFTKVTCLVYVCSILTVMLRVQINMVGGYLYRDPASISADLQENYLSNCKDLLNSGLDRLVAFFGEKSKNVLEAIPLNRNLKIDELEKIFWAIQVSARESREDPVNKLRQYVFTENGIDDAVYKSVVQDTLDLLESEDTKLLMTSCIDRSFVTLCDQISEFYGPNMKDEFVHTSDVKVAMAKLIPIINGLFSKNALINSLIQQLIANEKLKVLGANVYEAFSFSNNNFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1JZ21</accession>
    <name>A0A1Y1JZ21_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="27">Histone-lysine N-methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">PPYR_11631</name>
    </gene>
    <organism evidence="24">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="25 26" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">1611_PpyrPB1</strain>
            <tissue evidence="25">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="25" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="25">1611_PpyrPB1</strain>
            <tissue evidence="25">Whole body</tissue>
        </source>
    </reference>
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        <subcellularLocation>
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        <subcellularLocation>
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        <source>
            <dbReference type="PROSITE" id="PS51215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="JAV53481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="KAB0794792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="27">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2403" mass="268803" checksum="79D307CABEF801B3" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1JZ38</accession>
    <name>A0A1Y1JZ38_PHOPY</name>
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        <recommendedName>
            <fullName evidence="6">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PPYR_12300</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MELT/VEPH family.</text>
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        <property type="protein sequence ID" value="JAV52274.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01101816">
        <property type="protein sequence ID" value="JAV52276.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0795461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1JZ38"/>
    <dbReference type="Proteomes" id="UP000327044">
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    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:phosphatidylinositol-5-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Leucine-rich Repeat Variant"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
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        </location>
    </feature>
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        <location>
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        <location>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="JAV52276.1"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAB0795461.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="946" mass="103200" checksum="F0CD64A80F2707D1" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="4">Tudor domain-containing protein</fullName>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
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            <taxon>Coleoptera</taxon>
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            <taxon>Elateroidea</taxon>
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            <taxon>Lampyrinae</taxon>
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    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
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                <person name="Al-Wathiqui N."/>
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                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
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            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01095796">
        <property type="protein sequence ID" value="JAV55343.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1K1L9"/>
    <dbReference type="FunCoup" id="A0A1Y1K1L9">
        <property type="interactions" value="106"/>
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    <dbReference type="InParanoid" id="A0A1Y1K1L9"/>
    <dbReference type="OrthoDB" id="9995375at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="C:P granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034587">
        <property type="term" value="P:piRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
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        <property type="entry name" value="KH_dom_type_1_sf"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR050621">
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    <dbReference type="PANTHER" id="PTHR22948:SF29">
        <property type="entry name" value="FI02030P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22948">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
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    </dbReference>
    <dbReference type="Pfam" id="PF00567">
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    </dbReference>
    <dbReference type="SMART" id="SM00322">
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    </dbReference>
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        <location>
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    <feature type="domain" description="Tudor" evidence="4">
        <location>
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            <end position="358"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="197"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50304"/>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="JAV55343.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0793040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="456" mass="51367" checksum="95451B8A93A744F3" modified="2017-08-30" version="1">MKHILPSKSVTIALGLSVCGIGGYLLYLLLKKDDEYKATQKRSNYKTLEVSIPKEHVRSFIGRNGKNIKALQEESHTRISFKDDDNDEQRTCVIRGNRDACIHAKSLILEFIGAQPVLKSDEMIVPQNVVGKIIGRCGENIMEITTRSGAKVTVCNDKAAAHRKVLLKGTEEQINCAKLLITNIIKTYQLSQNELDSTLAKREPRAPPKSPTVNGTKGDALDSPTMLNGSPKVERMSPYPGQTGAQFEVYISAMLDPSHFWMQIVGPKATELDQLVEEMTEYYAKDENRDLHVLNSLEVGDVVAAVFKFDKKWYRAEVLKVMDNGGDSHVELYYVDYGDTDVIPSKEAFELRTDFLRLHFQAIECFLAQIEPKDGKWSDEALDKFEELAHVAQWKKLLAKINCYWNREKLTAKRESSPVPGIDLYDFNNDTDVDIAKELVDHGYAVFKNGCDPNLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1K2C6</accession>
    <name>A0A1Y1K2C6_PHOPY</name>
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        <recommendedName>
            <fullName evidence="3 16">Alkaline phosphatase</fullName>
            <ecNumber evidence="3 16">3.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PPYR_00602</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="20 21" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">1611_PpyrPB1</strain>
            <tissue evidence="20">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">1611_PpyrPB1</strain>
            <tissue evidence="20">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="14">Binds 1 Mg(2+) ion.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="14">Binds 2 Zn(2+) ions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the alkaline phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.1" evidence="3 16"/>
    <dbReference type="EMBL" id="GEZM01096720">
        <property type="protein sequence ID" value="JAV54628.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1K2C6"/>
    <dbReference type="FunCoup" id="A0A1Y1K2C6">
        <property type="interactions" value="129"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1K2C6"/>
    <dbReference type="OrthoDB" id="5818554at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004035">
        <property type="term" value="F:alkaline phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16012">
        <property type="entry name" value="ALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000008">
        <property type="entry name" value="Alkaline phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001952">
        <property type="entry name" value="Alkaline_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018299">
        <property type="entry name" value="Alkaline_phosphatase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11596">
        <property type="entry name" value="ALKALINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11596:SF91">
        <property type="entry name" value="ALKALINE PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00245">
        <property type="entry name" value="Alk_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00113">
        <property type="entry name" value="ALKPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00098">
        <property type="entry name" value="alkPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00123">
        <property type="entry name" value="ALKALINE_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9 14 16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="18" id="KW-0732">Signal</keyword>
    <keyword evidence="17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8 14 16" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033289597" description="Alkaline phosphatase" evidence="18">
        <location>
            <begin position="19"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="498"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="13">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="338"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="379"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="380"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="454"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR601952-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR601952-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="JAV54628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAB0803632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="530" mass="57469" checksum="091A98CBF7AFD10F" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1K406</accession>
    <name>A0A1Y1K406_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein phosphatase 1 regulatory subunit 35 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_12994</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
            <location evidence="1">Centriole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PPP1R35 family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01095977">
        <property type="protein sequence ID" value="JAV55228.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1K406"/>
    <dbReference type="InParanoid" id="A0A1Y1K406"/>
    <dbReference type="OrthoDB" id="8191506at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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            <begin position="40"/>
            <end position="144"/>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAB0793374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
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    <sequence length="167" mass="19651" checksum="D426B2675731EB71" modified="2017-08-30" version="1">MDKQPKKLTKKPAETIKLKCAISNDAAPEIENPKVCFDEPELNTALKFVREMESVENIRPKHLKSSTDLKIAKNLLDERATKQLNHPHHQKLYKNLMPLCTKRQPQVLPQISRDYQVIKDQEPVLSDFYTPKVLPEYSFRVPSQTAPRNLYRQFDGFKLYRTMRNWN</sequence>
</entry>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
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            <taxon>Lampyrinae</taxon>
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    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
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                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
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            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
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        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
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    <reference evidence="7" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
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        <text evidence="1">Belongs to the AB hydrolase superfamily. ABHD16 family.</text>
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        </source>
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        </source>
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    <sequence length="553" mass="62595" checksum="12BB9984546BEDE2" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
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            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
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            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
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        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
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        <property type="molecule type" value="Transcribed_RNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="TreeGrafter"/>
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        <location>
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        </location>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
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            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">The glycine cleavage system catalyzes the degradation of glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[glycine-cleavage complex H protein] + glycine + H(+) = N(6)-[(R)-S(8)-aminomethyldihydrolipoyl]-L-lysyl-[glycine-cleavage complex H protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:24304"/>
            <dbReference type="Rhea" id="RHEA-COMP:10494"/>
            <dbReference type="Rhea" id="RHEA-COMP:10495"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="1.4.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer. The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the GcvP family.</text>
    </comment>
    <dbReference type="EC" id="1.4.4.2" evidence="8"/>
    <dbReference type="EMBL" id="GEZM01086402">
        <property type="protein sequence ID" value="JAV59480.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0794984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1KGY4"/>
    <dbReference type="FunCoup" id="A0A1Y1KGY4">
        <property type="interactions" value="325"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1KGY4"/>
    <dbReference type="OrthoDB" id="6537869at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016594">
        <property type="term" value="F:glycine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004375">
        <property type="term" value="F:glycine dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00613">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000025">
        <property type="entry name" value="Glycine cleavage system P protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000005">
        <property type="entry name" value="Glycine dehydrogenase (decarboxylating), mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000007">
        <property type="entry name" value="glycine dehydrogenase (Decarboxylating), mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000007">
        <property type="entry name" value="Glycine dehydrogenase (decarboxylating), mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00711">
        <property type="entry name" value="GcvP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003437">
        <property type="entry name" value="GcvP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049316">
        <property type="entry name" value="GDC-P_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049315">
        <property type="entry name" value="GDC-P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020581">
        <property type="entry name" value="GDC_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00461">
        <property type="entry name" value="gcvP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001696">
        <property type="entry name" value="PRK00451.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11773:SF1">
        <property type="entry name" value="GLYCINE DEHYDROGENASE (DECARBOXYLATING), MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11773">
        <property type="entry name" value="GLYCINE DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21478">
        <property type="entry name" value="GcvP2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02347">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Glycine cleavage system P-protein N-terminal" evidence="9">
        <location>
            <begin position="40"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="Glycine dehydrogenase C-terminal" evidence="10">
        <location>
            <begin position="801"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="728"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00046415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR603437-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="JAV59480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAB0794984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="984" mass="109176" checksum="980B2FB927B995C4" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1KI41</accession>
    <name>A0A1Y1KI41_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Tropomyosin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PPYR_03737</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the tropomyosin family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01087875">
        <property type="protein sequence ID" value="JAV58427.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1KI41"/>
    <dbReference type="InParanoid" id="A0A1Y1KI41"/>
    <dbReference type="OrthoDB" id="128924at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000005">
        <property type="entry name" value="Tropomyosin alpha-1 chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000001">
        <property type="entry name" value="Tropomyosin alpha-1 chain isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.340:FF:000001">
        <property type="entry name" value="Tropomyosin alpha-1 chain isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000533">
        <property type="entry name" value="Tropomyosin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19269">
        <property type="entry name" value="TROPOMYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00261">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00194">
        <property type="entry name" value="TROPOMYOSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00326">
        <property type="entry name" value="TROPOMYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="JAV58427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0791937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="284" mass="32362" checksum="DC8D602C8B35BB86" modified="2017-08-30" version="1">MDAIKKKMQAMKLEKDNAQDKADAMEGQFKDANMRAEKVKEEVYEYTKKLAQVEADFETTKNNLEQANKDLETKEKTLNNAESEMAALNRKVQLIEEDLERSEERLGTASTKLAEASEAADESSRMCKVLENRALQDEERMDQLTAQLKEARMLAEDADNKSDEVSRKLAFVEDELEVAEDRVKGGDAKIMELEEELKVVGNSLKSLEVSEEKANQRVEEFKKQLKSLTVKLKEAEARAEYAEKAVKKLQKEVDRIEDELGINKDRYKSLADEMDSTFAELAGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1KLA5</accession>
    <name>A0A1Y1KLA5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Autophagy-related protein 101</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_10571</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">1611_PpyrPB1</strain>
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    </reference>
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        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATG101 family.</text>
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        <property type="entry name" value="ATG101"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00007130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="JAV62172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0796510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="218" mass="24964" checksum="45ADD24E31CA2AF1" modified="2017-08-30" version="1">MNARSEIFELTMEGRQVDEAVASLFHTILFHRSVGKFVYHGSSYSVGTIGYTDIDCDFIDLTYVCCTSSSLDRTLKREISNFSELLRGSDGTGIGQISLEFFQKKPSRWMLPPECSPWEVWTIRLELISLTNEDERQVCREKVGEILTDKILYITEVMNREEYIPKVPDQADLNQIFDTSYHDIQPYLFKLRYSLSGPSSETSVGSAMKKLIKETLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1KNU1</accession>
    <name>A0A1Y1KNU1_PHOPY</name>
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        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PPYR_08175</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GEZM01080460">
        <property type="protein sequence ID" value="JAV62131.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="2013972at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
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        <property type="entry name" value="Sec12-like"/>
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    </dbReference>
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        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23284">
        <property type="entry name" value="PROLACTIN REGULATORY ELEMENT BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23284:SF0">
        <property type="entry name" value="PROLACTIN REGULATORY ELEMENT-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WD_REPEATS_REGION"/>
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    </dbReference>
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    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="3 11" id="KW-0853">WD repeat</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="395"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="198"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
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    </evidence>
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        </source>
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        <source>
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        </source>
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        </source>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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    </evidence>
    <sequence length="418" mass="46783" checksum="764BAFA2C8BF66E6" modified="2017-08-30" version="1">MPHTRRNFDGLLAKVNFPLYTVQMLTNRHVIVGGGGGSAKTGVANGFEIYELSHDGERFIVEEVIRHETGPSVVMNCSTYNDKKHSFLVAGQESHCQLYNVRTVLINNNVEVETVNPHEDIRNRKNKPIQTENNHTNNNKKLKFVITPSDSVQTDFLQEEPLQRVVRISRLSKVMATGGTDGIVRLWGFPNLKQLHTLKAHKEEIDDLDFSPCQKYLISIAKDGLAILWDYSSGKEIRRLTWQQPEGSKYLYKRCRFGVVEGAKNLSALYMLANPTGRAGKQKSYLQKWIPQEGQLYKIAALDESLSALAVRDDGRFVALGTMFSGSVSIYIAFSLQRVLHIPGAHSMFVTGLEFLPVSSDTHTVNSIAEAAVLSISVDNQVCIHSLPFRSTLPAWLAIIVIILTIFFTFVLCSYLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1KPZ9</accession>
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        <name evidence="9" type="ORF">PPYR_01783</name>
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    <organism evidence="8">
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        <name type="common">Common eastern firefly</name>
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        <lineage>
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            <taxon>Insecta</taxon>
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            <taxon>Coleoptera</taxon>
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            <taxon>Lampyridae</taxon>
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            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
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                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the Integrator subunit 14 family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01076985">
        <property type="protein sequence ID" value="JAV63489.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1KPZ9"/>
    <dbReference type="FunCoup" id="A0A1Y1KPZ9">
        <property type="interactions" value="2407"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1KPZ9"/>
    <dbReference type="OrthoDB" id="2374335at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:integrator complex"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:snRNA 3'-end processing"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="vWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="von Willebrand factor, type A domain"/>
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    </dbReference>
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        <property type="entry name" value="INTS14"/>
    </dbReference>
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        <property type="entry name" value="IntS14_b-barrel"/>
    </dbReference>
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        <property type="entry name" value="IntS14_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13532">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13532:SF3">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19435">
        <property type="entry name" value="IntS14_b-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="5">
        <location>
            <begin position="3"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Integrator complex subunit 14 beta-barrel" evidence="6">
        <location>
            <begin position="209"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="Integrator complex subunit 14 C-terminal" evidence="7">
        <location>
            <begin position="396"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00061449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF19435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="JAV63489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0804813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="500" mass="55404" checksum="00B9BCFDFA25DD1E" modified="2017-08-30" version="1">MPTVLLLDVSLSMVRPVQISENVEISRKYLAIQGINAFLDCLSVHSRLEFIALAAFSSLYEERCAFTRDYNAIKLELQKLEDHDKTAIESALHGVNQLVLGEWGNNSACQIVLITDGNAGIGPMSLSESFSTLNHRNVSNPFPLPFSFPAKLHVVCIAPPDDPNLMKSKPLYQRLVDMAGYNGSLLIPEGGLSEASVVTMFQKLAEEMYTSFRGTLKCGNLESRIMLSPAPIPYIKVTDFDSQTYVLSELIEVCGFIPISDVGSPMAISRHLILPTNNLGKENVPLSMEIDLTSDDDTTEDGKNPSFCVLLHGALKVENMSALVTVGDNWFGFIYSWADSKKKSNLMLTVLTPGSDAIPWLGDLCHLDSTDNLPPDQIGSFPVRPSEKRSYSQNGVVWIRQSGLQSDIQKILRHARKLPEKTQQFYKELNRLRKAAISLGFLDLLNGLAYIFEQECTQLPGSAHPDCALQLTHAAEVLRKTQNKDIKFVILPLHTNYNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1KR34</accession>
    <name>A0A1Y1KR34_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_13065</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01075900">
        <property type="protein sequence ID" value="JAV63889.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1KR34"/>
    <dbReference type="InParanoid" id="A0A1Y1KR34"/>
    <dbReference type="OrthoDB" id="10063348at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005942">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:1-phosphatidylinositol-3-kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009968">
        <property type="term" value="P:negative regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09923">
        <property type="entry name" value="SH2_SOCS_family"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
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        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="SOCS_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036036">
        <property type="entry name" value="SOCS_box-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10155">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10155:SF16">
        <property type="entry name" value="SUPPRESSOR OF CYTOKINE SIGNALING 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SOCS box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0341">Growth regulation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="2" id="KW-0734">Signal transduction inhibitor</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="SH2" evidence="6">
        <location>
            <begin position="104"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="SOCS box" evidence="7">
        <location>
            <begin position="211"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="JAV63889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0793445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="272" mass="30149" checksum="2EC66EA20CF3683F" modified="2017-08-30" version="1">MLGCSTVCPKCQHQFACCGPTPPCNRTRRSLHALTGGGLVATLNQSLVPVGPCLSPQISPSAPLAFVIPPFAPLQPTISPIEAKPENELQKLSDTVRALRQSGWYYEGITYQQSHDLLKNKPLGTFLVRESSDPRFLFSLSVQTERGPTSVRIHYINGYFRLDSQPHLQGAMPLFPSVVELVQHYVNQRRNLRNGAQVWVDSNGSWYSAILLDKPLRKDDGAPSLKHLARLVVHKAIQANGMPRLALLPPPHTQLELPPSLTTYLSQYPYSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1KUM5</accession>
    <name>A0A1Y1KUM5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Dedicator of cytokinesis protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PPYR_08277</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the DOCK family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01073453">
        <property type="protein sequence ID" value="JAV65082.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A1Y1KUM5">
        <property type="interactions" value="1064"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1KUM5"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017124">
        <property type="term" value="F:SH3 domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11872">
        <property type="entry name" value="SH3_DOCK_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.350:FF:000001">
        <property type="entry name" value="dedicator of cytokinesis protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.410:FF:000003">
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</entry>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
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                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
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        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
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            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="2084" mass="230219" checksum="FC46922715635175" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1L4L0</accession>
    <name>A0A1Y1L4L0_PHOPY</name>
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        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_00468</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
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        <property type="protein sequence ID" value="JAV68622.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01064872">
        <property type="protein sequence ID" value="JAV68623.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="term" value="C:cytosol"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:nucleus"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:ubiquitin binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:autophagosome assembly"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:Golgi organization"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:membrane fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:nuclear membrane reassembly"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="entry name" value="NSFL1 (p97) cofactor (p47)"/>
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    </dbReference>
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        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR23333">
        <property type="entry name" value="UBX DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08059">
        <property type="entry name" value="SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UBA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00553">
        <property type="entry name" value="SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00166">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="181"/>
            <end position="244"/>
        </location>
    </feature>
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        <location>
            <begin position="294"/>
            <end position="370"/>
        </location>
    </feature>
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            <end position="85"/>
        </location>
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            <begin position="61"/>
            <end position="73"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS51399"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="JAV68623.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAB0803498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="372" mass="41024" checksum="463332F24F9A2DEC" modified="2017-08-30" version="1">MADNDEKLQQFITVTGVDEERARFYLESSAWQLEVALASFYENDGEIEQPPTPNPVEVGDSPPSEQSPTSPEQVKPKPRSKITNSRFATIHTVHSSSEDEEEGQAFYAGGSEHSGQQVLGPPRHRDMVSDMFKAVREHGVEILEPAATGAHTSAFTGTGYKLGQTGNDSETIPGARSSSRPEEVTLKLWRDGFSLNDGDLRQYTDPQQTEFLDSIRRGEIPPELRQGNSEVHLSMEDRRTETFKQEIEKRTKVFSGQGHTLGSPTPAVIGAPPLQEKDSALNETKAKEKLSVDTSQPTTNIQIRLADGTRLVAQFNHMHTVGHIRSFIINARPQYGLNPFALLSSYPSRDLGDSETIAEAGLLNAAIMQKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LFN3</accession>
    <name>A0A1Y1LFN3_PHOPY</name>
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        <recommendedName>
            <fullName evidence="2">10-formyltetrahydrofolate dehydrogenase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PPYR_03371</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(6R)-10-formyltetrahydrofolate + NADP(+) + H2O = (6S)-5,6,7,8-tetrahydrofolate + CO2 + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10180"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:195366"/>
            <dbReference type="EC" id="1.5.1.6"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the GART family.</text>
    </comment>
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        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KAB0791571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0016155">
        <property type="term" value="F:formyltetrahydrofolate dehydrogenase activity"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009258">
        <property type="term" value="P:10-formyltetrahydrofolate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.10:FF:000002">
        <property type="entry name" value="10-formyltetrahydrofolate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000050">
        <property type="entry name" value="Aldehyde dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000026">
        <property type="entry name" value="Aldehyde dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000008">
        <property type="entry name" value="Cytosolic 10-formyltetrahydrofolate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.25.10">
        <property type="entry name" value="Formyl transferase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.170">
        <property type="entry name" value="Formyl transferase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011407">
        <property type="entry name" value="10_FTHF_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
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    <sequence length="915" mass="100520" checksum="D6096803CD1B60EE" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
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                <person name="Lewis S.M."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
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                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
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            <dbReference type="PubMed" id="30324905"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
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        </source>
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</entry>
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                <person name="Al-Wathiqui N."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
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                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
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                <person name="Debat H.J."/>
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                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
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                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
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                <person name="Oba Y."/>
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            <dbReference type="PubMed" id="30324905"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">1611_PpyrPB1</strain>
            <tissue evidence="16">Whole body</tissue>
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    <reference evidence="16" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="16">1611_PpyrPB1</strain>
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        </source>
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    <comment type="function">
        <text evidence="9">Mitochondrial transporter mediating uptake of thiamine diphosphate into mitochondria. It is not clear if the antiporter activity is affected by the membrane potential or by the proton electrochemical gradient.</text>
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            <text>thiamine phosphate(out) + thiamine diphosphate(in) = thiamine phosphate(in) + thiamine diphosphate(out)</text>
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            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
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        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01053537">
        <property type="protein sequence ID" value="JAV74021.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01053536">
        <property type="protein sequence ID" value="JAV74022.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1LM70"/>
    <dbReference type="FunCoup" id="A0A1Y1LM70">
        <property type="interactions" value="411"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1LM70"/>
    <dbReference type="OrthoDB" id="18574at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090422">
        <property type="term" value="F:thiamine pyrophosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000011">
        <property type="entry name" value="Mitochondrial thiamine pyrophosphate carrier 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 13 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 14" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="13">
        <location>
            <begin position="5"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="13">
        <location>
            <begin position="107"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="13">
        <location>
            <begin position="206"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00050799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="JAV74021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAB0796854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="307" mass="34715" checksum="3CC1B0E0F70AFF18" modified="2017-08-30" version="1">MGKKLRHYDLIIAGATSGFLTRATCQPLDVIKIRFQLQVEPISYRRTSKYHSILQATSLIAKEEGLKALWKGHVPAQLLSITYGMVQFWCFDTLMNQSKLLPLDTRYKPIVTFLCGSIAGCSATLASFPFDVVRTRLVAQGEKKRLYSGVIDAFRYILKNESILVLYRGILPTFIQVAPHAGAQFLSYRVFDNMYRAFFNIAQNTYTLPGNLVAGSLAGLVAKTLIYPFDLVKKRMQIQGVHEHRKEFGAVFSCRGMIDCCRKILRTEGPFALFKGLYPSLWKAVFTTAMHFATYEGTCKIISDFRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LNF4</accession>
    <name>A0A1Y1LNF4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Casein kinase II subunit alpha</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PPYR_06283</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">1611_PpyrPB1</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">1611_PpyrPB1</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. The alpha chain contains the catalytic site. May participate in Wnt signaling.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Tetramer of two alpha and two beta chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="GEZM01055133">
        <property type="protein sequence ID" value="JAV73116.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01055130">
        <property type="protein sequence ID" value="JAV73119.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000004">
        <property type="protein sequence ID" value="KAB0800543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1LNF4"/>
    <dbReference type="FunCoup" id="A0A1Y1LNF4">
        <property type="interactions" value="1763"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1LNF4"/>
    <dbReference type="OrthoDB" id="10254671at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005956">
        <property type="term" value="C:protein kinase CK2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14132">
        <property type="entry name" value="STKc_CK2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000059">
        <property type="entry name" value="Casein kinase II subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000088">
        <property type="entry name" value="Casein kinase II subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045216">
        <property type="entry name" value="CK2_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24054">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24054:SF0">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="80"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00057837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00071078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="JAV73116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAB0800543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="396" mass="46520" checksum="F9C81C53975959D1" modified="2017-08-30" version="1">MLIICSRLAKLCLKQVVATHTAGTYVRRLAKSARLSARIHKRNMAAASRARIYADVNSHKPREYWDYESYVVDWGQQDNYQLVRKLGRGKYSEVFEAINVTNNEKCVVKILKPVKKKKIKREIKILENLRGGTNIITLQAVVKDPVSRTPALIFEHVNNTDFKQLYQTLTDFDIRYYLYELLKALDYCHSMGIMHRDVKPHNVMIDHENRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEELFEYLDKYHIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHLERLTARDAMEHAYFYPVVKEQCRMMAVGSSSPTPLTGTLSVVVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LRX0</accession>
    <name>A0A1Y1LRX0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 13">Superoxide dismutase</fullName>
            <ecNumber evidence="6 13">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PPYR_12972</name>
        <name evidence="18" type="ORF">PPYR_12973</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17 19" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">1611_PpyrPB1</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">1611_PpyrPB1</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="function">
        <text evidence="2">Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 13">
            <text>2 superoxide + 2 H(+) = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the iron/manganese superoxide dismutase family.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="6 13"/>
    <dbReference type="EMBL" id="GEZM01050447">
        <property type="protein sequence ID" value="JAV75588.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1LRX0"/>
    <dbReference type="FunCoup" id="A0A1Y1LRX0">
        <property type="interactions" value="750"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1LRX0"/>
    <dbReference type="OrthoDB" id="239262at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098803">
        <property type="term" value="C:respiratory chain complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.990:FF:000001">
        <property type="entry name" value="Superoxide dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.55.40.20:FF:000003">
        <property type="entry name" value="Superoxide dismutase [Mn], mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.990">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.40.20">
        <property type="entry name" value="Iron/manganese superoxide dismutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050265">
        <property type="entry name" value="Fe/Mn_Superoxide_Dismutase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001189">
        <property type="entry name" value="Mn/Fe_SOD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019833">
        <property type="entry name" value="Mn/Fe_SOD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019832">
        <property type="entry name" value="Mn/Fe_SOD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019831">
        <property type="entry name" value="Mn/Fe_SOD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036324">
        <property type="entry name" value="Mn/Fe_SOD_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036314">
        <property type="entry name" value="SOD_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11404">
        <property type="entry name" value="SUPEROXIDE DISMUTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11404:SF6">
        <property type="entry name" value="SUPEROXIDE DISMUTASE [MN], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02777">
        <property type="entry name" value="Sod_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00081">
        <property type="entry name" value="Sod_Fe_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000349">
        <property type="entry name" value="SODismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01703">
        <property type="entry name" value="MNSODISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54719">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46609">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00088">
        <property type="entry name" value="SOD_MN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0464">Manganese</keyword>
    <keyword evidence="7 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Manganese/iron superoxide dismutase N-terminal" evidence="14">
        <location>
            <begin position="21"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="Manganese/iron superoxide dismutase C-terminal" evidence="15">
        <location>
            <begin position="110"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000349-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="JAV75588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAB0793352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAB0793353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="219" mass="24891" checksum="4CEB4149B5180B80" modified="2017-08-30" version="1">MFGKSFRHLSTVLKTQPIRTKHELPQLPYSYEALEPIISRDIMMLHHQKHHQTYVTNLNLAEEKLRSAAEKHDITAMISLQPAVKFNGGGHINHSIFWQNLSPNQTKASDELCQAMVQSFGSFDKFKDDLSAATVAIQGSGWGWLGYCTKTHRLKIATCANQDPLQATTGLVPLFGIDVWEHAYYLQYKNVRPDYVKAVFDIANWKDISERFAKAKATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LXU9</accession>
    <name>A0A1Y1LXU9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glutathione peroxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_14800</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glutathione peroxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01045097">
        <property type="protein sequence ID" value="JAV77921.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1LXU9"/>
    <dbReference type="FunCoup" id="A0A1Y1LXU9">
        <property type="interactions" value="1325"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1LXU9"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00340">
        <property type="entry name" value="GSH_Peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000025">
        <property type="entry name" value="Glutathione peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000889">
        <property type="entry name" value="Glutathione_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029760">
        <property type="entry name" value="GPX_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592">
        <property type="entry name" value="GLUTATHIONE PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592:SF134">
        <property type="entry name" value="PHOSPHOLIPID HYDROPEROXIDE GLUTATHIONE PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00255">
        <property type="entry name" value="GSHPx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000303">
        <property type="entry name" value="Glutathion_perox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01011">
        <property type="entry name" value="GLUTPROXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00763">
        <property type="entry name" value="GLUTATHIONE_PEROXID_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51355">
        <property type="entry name" value="GLUTATHIONE_PEROXID_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 6" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0712">Selenocysteine</keyword>
    <feature type="domain" description="Thioredoxin" evidence="7">
        <location>
            <begin position="29"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000303-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="JAV77921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0792841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="190" mass="21542" checksum="DA4E0FCA1926BC7B" modified="2017-08-30" version="1">MLSHLYRHIHKVSGVSCGFRRSLMAAANPESASSIYDFSAKTISGEEISLDKYKDHVTIIVNVASQCGLTENHYKELNELYDQYAEEKGLRILAFPCNQFARQEPGDSAEICTFVSKKNVKFDMFDKIDVNGSKTHPLWKYLKHVQGGTLGNFIKWNFTKFVIDKNGHPVERFGPNTTPKALVPALEKLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LYT4</accession>
    <name>A0A1Y1LYT4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PPYR_12277</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">trans-Golgi network membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GEZM01044355">
        <property type="protein sequence ID" value="JAV78281.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01044354">
        <property type="protein sequence ID" value="JAV78282.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0795438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1LYT4"/>
    <dbReference type="InParanoid" id="A0A1Y1LYT4"/>
    <dbReference type="OrthoDB" id="1854502at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001881">
        <property type="term" value="P:receptor recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01247">
        <property type="entry name" value="PH_FAPP1_FAPP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000085">
        <property type="entry name" value="Pleckstrin homology domain-containing family A member 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045188">
        <property type="entry name" value="Boi1/Boi2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22902:SF27">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY A MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22902">
        <property type="entry name" value="SESQUIPEDALIAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="6">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="JAV78281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0795438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="214" mass="24314" checksum="DFEC51682DECC88F" modified="2017-08-30" version="1">MEGVLWKWTNYWNGWQTRWFVLENGILTYYKSQEEVNKGSKGSIKVQACEIIVHTIDTTRLDLDIPGEQHLYLKAATPQERQGWLIALGTAKACVSNRSRKDTSDNIFYNSESEVDTLKSKKSELRLYCDLLMQQVHTVKTAANVEGGPEISKMDEATSLLTATCDTFIKTLEDCMKLSHSNVLYEITQHNDAIIPNIGVSKKRTILRPHSNDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1M0A5</accession>
    <name>A0A1Y1M0A5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DNA replication licensing factor MCM6</fullName>
            <ecNumber evidence="13">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PPYR_04118</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">1611_PpyrPB1</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">1611_PpyrPB1</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the MCM2-7 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="13"/>
    <dbReference type="EMBL" id="GEZM01045606">
        <property type="protein sequence ID" value="JAV77725.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0801932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1M0A5"/>
    <dbReference type="FunCoup" id="A0A1Y1M0A5">
        <property type="interactions" value="1401"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1M0A5"/>
    <dbReference type="OrthoDB" id="1744952at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990518">
        <property type="term" value="F:single-stranded 3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902969">
        <property type="term" value="P:mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17757">
        <property type="entry name" value="MCM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000003">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000091">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1640.10:FF:000004">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000115">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.870">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008049">
        <property type="entry name" value="MCM6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041024">
        <property type="entry name" value="Mcm6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF43">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18263">
        <property type="entry name" value="WHD_MCM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01662">
        <property type="entry name" value="MCMPROTEIN6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 13" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 13" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 13" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="15">
        <location>
            <begin position="338"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="659"/>
            <end position="683"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU368064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="JAV77725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAB0801932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="796" mass="89741" checksum="F3FFCCCAA93FFB4B" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1M604</accession>
    <name>A0A1Y1M604_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cytochrome b5-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_13860</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play a role in muscle cell metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cytochrome b5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01039755">
        <property type="protein sequence ID" value="JAV81221.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01039754">
        <property type="protein sequence ID" value="JAV81222.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0794240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1M604"/>
    <dbReference type="FunCoup" id="A0A1Y1M604">
        <property type="interactions" value="607"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1M604"/>
    <dbReference type="OrthoDB" id="260519at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000020">
        <property type="entry name" value="Cytochrome b5-related protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053100">
        <property type="entry name" value="Cytochrome_b5-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16740">
        <property type="entry name" value="CYTOCHROME B5-RELATED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16740:SF1">
        <property type="entry name" value="CYTOCHROME B5-RELATED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0349">Heme</keyword>
    <keyword evidence="3 6" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="244"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="7">
        <location>
            <begin position="30"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00055674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00073492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="JAV81222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0794240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="432" mass="49463" checksum="DE223E6F98A69B8D" modified="2017-08-30" version="1">MSLASEVKLSLTPNYPKKFAGLITGDKWFEAKREGDGAEGLWRIHDGLYDVSEFVQSHPGGSSWLEMTKGTDITEAFESHHLSSAPEQMLKKFYVRKAVKHRNSPFTFEEDGFYRTLKRNIQPVLKTIPKNTSRTTDLVTDALVVATFLTAICACKLSSFAIGVISACILTFGSIASHNHFHKRDNFRMYYFNLCLMDFRGWRVSHVLSHHLFTNTIYDLEAVTWEVLAPHFPVKKPFFTKCRSFVTITLLWVAFYFLAYLFKIISMIQSRKVYISDFIPFTLPLAMYLTCGVDLQVVLKMWLFIVTVSSFVFAAIGTSASHHHPDAFHEGDAPRAKKLDFGIHQLDTTYDRCEVTGNPFLVLTTFGDHALHHLFPTIDHGALQYLYPVFEKTMKEFGIDNQMKPLSEMFVGLYRQLLREEPHLLPRGSRNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1M928</accession>
    <name>A0A1Y1M928_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_14533</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
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                <person name="Weng J.-K."/>
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        </source>
    </reference>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="JAV82302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0792574.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
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    </evidence>
    <sequence length="99" mass="10722" checksum="EB9CD34E2B0874D3" modified="2017-08-30" version="1">MFGLFTRGYVTKPPAPSLKPSPRSKTNPGSSRTCSRQNILQKPPPQTQVHELPKSRTLAGGMSEEEETGQCIAGHTPHQVFKSAGPPFASREVNLVLLV</sequence>
</entry>
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    </gene>
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        <name type="common">Common eastern firefly</name>
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            <taxon>Insecta</taxon>
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            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
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    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
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                <person name="Weng J.K."/>
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            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
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            <dbReference type="PubMed" id="30324905"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <property type="molecule type" value="Transcribed_RNA"/>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
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            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
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                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
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    <reference evidence="14" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="UBC_2"/>
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    </dbReference>
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    <keyword evidence="4 11" id="KW-0833">Ubl conjugation pathway</keyword>
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        <location>
            <begin position="2"/>
            <end position="152"/>
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                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
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                <person name="Schmitz R.J."/>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
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                <person name="Bessho-Uehara M."/>
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                <person name="Debat H.J."/>
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                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
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    <reference evidence="18" key="1">
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            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
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                <person name="Oba Y."/>
                <person name="Weng J.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">1611_PpyrPB1</strain>
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        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
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                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">1611_PpyrPB1</strain>
            <tissue evidence="19">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = a 5-methyl-2'-deoxycytidine in DNA + S-adenosyl-L-homocysteine + H(+)</text>
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            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:85452"/>
            <dbReference type="ChEBI" id="CHEBI:85454"/>
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        </reaction>
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    <comment type="subcellular location">
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    </comment>
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        <property type="entry name" value="Vaccinia Virus protein VP39"/>
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    </dbReference>
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1N4M6</accession>
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        <submittedName>
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            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
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                <person name="Fallon T.R."/>
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                <person name="Lewis S.M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <proteinExistence type="predicted"/>
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        </location>
    </feature>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="JAV92832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0794044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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    <organism evidence="1">
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            <taxon>Coleoptera</taxon>
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        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01011240">
        <property type="protein sequence ID" value="JAV93574.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01011238">
        <property type="protein sequence ID" value="JAV93576.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0800050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1N6P7"/>
    <dbReference type="InParanoid" id="A0A1Y1N6P7"/>
    <dbReference type="OrthoDB" id="284357at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="JAV93574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0800050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="343" mass="40511" checksum="6C568F5EF7318377" modified="2017-08-30" version="1">MTTYESISTDITNLFASFDKYVNMYETNTWLNSVSIEELKNGFKLGKLIEDSVRNLQLKQCTNTFFSVLNAWWKQKSRTKVYSVDFFLKACDNLLTKFFQKNIPIQTLDNAIRMYTSLFPRERFEKVISRLILMSASHTQIIDYTIANKDNIDIQFLQCRLLLTNWLQECECGRIENVKGVISNMFLSYKLQSTLPLLVTILTVNIENEAPVTNIILENLYMKMEDRSVLSKQFWLSLFRYVDRQRLSKVCLRYNEFLIKLFDFIIYIGCMMNYIPHNSEMKWMGDPETSICPNLMYEDLVKVVKFLYRDHLDLGRYIDLRIAEAKKGLNVKLWNQLMSDIVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1NBM0</accession>
    <name>A0A1Y1NBM0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tetraspanin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_06758</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the tetraspanin (TM4SF) family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01007288">
        <property type="protein sequence ID" value="JAV95263.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0798878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1NBM0"/>
    <dbReference type="FunCoup" id="A0A1Y1NBM0">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1NBM0"/>
    <dbReference type="OrthoDB" id="10051670at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03127">
        <property type="entry name" value="tetraspanin_LEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1450.10">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000301">
        <property type="entry name" value="Tetraspanin_animals"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282:SF555">
        <property type="entry name" value="TETRASPANIN-2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002419">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00259">
        <property type="entry name" value="TMFOUR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="25"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="208"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="163"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR002419-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="JAV95263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0798878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="248" mass="27859" checksum="6B38E55E17DE88D0" modified="2017-08-30" version="1">MAGKGEGAGEGTLLKLENQIMVIKYTLLFTNVILWMIGAAIFALTLWMRFEPGLEEWIQKLDLHQFYNGVYLLLVAAILMMIISFVGCISSLQENQTALLIYVGSQALGFVFGGIGSAFLLENSARDSLIQPLIKESMRRLIMYSREDYAQKTLAMIQESIGCCGAEGAHDYLNLRQPLPTQCRDTVTGNPFFYGCVDELTWYFEEKAAWVTGLTMAVCFLLVCNAVMAIILIQAIKKEQEESTEYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1NF24</accession>
    <name>A0A1Y1NF24_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="14">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PPYR_05594</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="19 20" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">1611_PpyrPB1</strain>
            <tissue evidence="19">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">1611_PpyrPB1</strain>
            <tissue evidence="19">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">E3 ubiquitin-protein ligase that is required for specification of R7 photoreceptor cell fate in the eye by mediating the ubiquitination and subsequent proteasomal degradation of Tramtrack (ttk). E3 Ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Acts via the formation of a complex with ebi and phyl that ubiquitinates the transcription repressor ttk, a general inhibitor of photoreceptor differentiation, in a subset of photoreceptor cells in the eye, leading to the differentiation of cells into neurons. Also involved in external sensory organ development.</text>
    </comment>
    <comment type="function">
        <text evidence="14">E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of some E3 complex at least composed of sina, ebi and phyl. Interacts with eff.</text>
    </comment>
    <comment type="domain">
        <text evidence="14">The RING-type zinc finger domain is essential for ubiquitin ligase activity.</text>
    </comment>
    <comment type="domain">
        <text evidence="14">The SBD domain (substrate-binding domain) mediates the interaction with substrate proteins. It is related to the TRAF family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the SINA (Seven in absentia) family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="14"/>
    <dbReference type="EMBL" id="GEZM01003885">
        <property type="protein sequence ID" value="JAV96501.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01003884">
        <property type="protein sequence ID" value="JAV96502.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01003883">
        <property type="protein sequence ID" value="JAV96503.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000003">
        <property type="protein sequence ID" value="KAB0801240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1NF24"/>
    <dbReference type="FunCoup" id="A0A1Y1NF24">
        <property type="interactions" value="1384"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1NF24"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007601">
        <property type="term" value="P:visual perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03829">
        <property type="entry name" value="Sina"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.210.10:FF:000002">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000041">
        <property type="entry name" value="E3 ubiquitin-protein ligase SINAT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018121">
        <property type="entry name" value="7-in-absentia-prot_TRAF-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004162">
        <property type="entry name" value="SINA-like_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049548">
        <property type="entry name" value="Sina-like_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013010">
        <property type="entry name" value="Znf_SIAH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45877">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SIAH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45877:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SINA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21362">
        <property type="entry name" value="Sina_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03145">
        <property type="entry name" value="Sina_TRAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21361">
        <property type="entry name" value="Sina_ZnF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51081">
        <property type="entry name" value="ZF_SIAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 14" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10" id="KW-0844">Vision</keyword>
    <keyword evidence="9 14" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 13 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="16">
        <location>
            <begin position="52"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="SIAH-type" evidence="17">
        <location>
            <begin position="104"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00060311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00062579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU201113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="JAV96502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAB0801240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="295" mass="32323" checksum="A01790D4A6020286" modified="2017-08-30" version="1">MAQLQMQKRGRGNNTSGEPSSSGGTASATNQLPIMPTSPGTLTDELAALFECPVCFEIVLPPIMQCHVGHLVCASCRPKLSCCPTCRGTLGNIRNLAMEKVANNLMFPCKHKQTGCRVSLGLNEKAEHEEICEFRPYSCPCPGASCSWQGQLEKVMGHLQHVHKNITTLNGEDIVFLATDINLPGAVDWVMMQSCFGHHFMLVLEKQEKCDGHTQFFAIVQLIGSRKQAEHFAYRLELNGNRRRLTWEAMPRSSHEGVASAIMGSDCLVFDTSIAQLFADNNGNLGINVTISVVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1NLI2</accession>
    <name>A0A1Y1NLI2_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_08821</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01003563">
        <property type="protein sequence ID" value="JAV96727.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1NLI2"/>
    <dbReference type="FunCoup" id="A0A1Y1NLI2">
        <property type="interactions" value="105"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1NLI2"/>
    <dbReference type="OrthoDB" id="10064535at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006393">
        <property type="term" value="P:termination of mitochondrial transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003690">
        <property type="entry name" value="MTERF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15437:SF7">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15437">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="JAV96727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0797828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="478" mass="56240" checksum="CD821EF6ACCA6F6D" modified="2017-08-30" version="1">MLFKRNLFIISKLPIVKTRSWSSKSINAFCNLFDLSRGEFDSYRKETNIPSLEVEHLNEISNLRERINIPVQEWLLFPSLLKENARHLEECYLQLKEGGFERIDARILANYRRLVQKSIRLLKAGGYLSAHVSVTESFLKHLNHKLSIENLSEESTFHFVYRTVLTHCLMSRFNTTQSVIEKFFRMYPIVKIKSFQTHLENFQLADKLNFPTDDIFQCGFLLSTHPKNTYRLLREVPTLAGMDIHEAIRLKPRLLRIPSKKIKEIYRCLREANIADDVIQHHLSIFFLSPNTVALRIKDARSIPEFNFFINDPNFLRLIINFGETRSRIAYLKEMKIKCTSLSVLCYKPEQFIAFLQQGLNMHRHEEVTKFIQQLLGSHSRRIGVNLKKHVHHRCVNLSRIEDNYEYLRELNFSREAIINAIPVLLYSRGKVKAAYESARDYLKGDGTEIEHLNLILYFMEREHHFTGNGIWNHTENA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A009</accession>
    <name>A0A5N4A009_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Saposin B-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_14984</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01001017">
        <property type="protein sequence ID" value="KAB0790608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A009"/>
    <dbReference type="InParanoid" id="A0A5N4A009"/>
    <dbReference type="OrthoDB" id="6701703at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024309055" description="Saposin B-type domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0790608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="199" mass="23202" checksum="EDEA5E010E7FF7A4" modified="2020-02-26" version="1">MNFLQFLYVCYLFLQRYTLFHFGNDQTITNPQTYAITFEAPHNTPNTDLKLRHPFEDITLYNVYTTIYMRCPICLHIAKEINHVIEVNLDEATDPLEEIKIISDLLKEFCPTHFDSSKIRKAVLKCGGLFTLLKYGSHGLDEKWNTMLKGICYRYVNHINVHNLYHKVIEKQFPMGHMLCRSGGVFRDCANVDIDIDGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A0A6</accession>
    <name>A0A5N4A0A6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PPYR_05231</name>
        <name evidence="7" type="ORF">PPYR_14847</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000873">
        <property type="protein sequence ID" value="KAB0790708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000003">
        <property type="protein sequence ID" value="KAB0800877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A0A6"/>
    <dbReference type="InParanoid" id="A0A5N4A0A6"/>
    <dbReference type="OrthoDB" id="21467at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12307">
        <property type="entry name" value="RRM_NIFK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46754">
        <property type="entry name" value="MKI67 FHA DOMAIN-INTERACTING NUCLEOLAR PHOSPHOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="39"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="16"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0790708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0800877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="198" mass="23298" checksum="3396033F19E11971" modified="2020-02-26" version="1">MNSKVNDTKPKSKQPNLRKKTSPRITKNKKGKLPRKQHGFVYLGHIPHGFYEEEMRSYFGQFGKVINVRLYRSPRTGKSQGYAFIEFEHSEVAKIAAETMDNYLMFKKRLEAKFVPADKLKNLRMSFTPSWTAENYPLKEKRERLNQAKNADPDHDTYIRHCHKWMSSVRKTMLKLKELGIDYAFQPVDVPVELKNVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A0G0</accession>
    <name>A0A5N4A0G0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_15488</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000780">
        <property type="protein sequence ID" value="KAB0790768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A0G0"/>
    <dbReference type="InParanoid" id="A0A5N4A0G0"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF269">
        <property type="entry name" value="NUCLEASE HARBI1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="8">
        <location>
            <begin position="70"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0790768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="303" mass="34199" checksum="6E9B340CAC9627F6" modified="2020-02-26" version="1" fragment="single">FLATGDSFKTISFSFRLGRSTVQSIIHHTCRIIVDILLEEVMPVPNEDTWNTIADYFWKMWQFPNCIGALDGKHCVIQAPKNSGSLYWNYKKTFSLVLLALVDAQYNFIAVDVGAYGKNSDAGILSNSNLGTSLENGSINIPRGKKLPGSDVDLPMIIVGDEGFPLKTYLMRPYPGANLDNEKKIFNYRLSRARRVSENAFGILQQKFRIYTRRLQGTPENLSVIILATCVLHNFIRQRERYAHIARVSDSGDSTLETSENLQSLRPTRGRATNAAFQVRDLLRTYFVSPAGQVEWQHKATDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-06-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A0N8</accession>
    <name>A0A5N4A0N8_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_15130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000735">
        <property type="protein sequence ID" value="KAB0790828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A0N8"/>
    <dbReference type="InParanoid" id="A0A5N4A0N8"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0790828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="76" mass="9089" checksum="D379008B5A2E2D98" modified="2020-02-26" version="1">MTDQEIEVVCGAMQTERERELRNQIIAKYKSENVAIIRGLGVIPSTIKMEEGRHKDMWFQVYKDLDLYNTFWVFYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A0U2</accession>
    <name>A0A5N4A0U2_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="50">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="50" type="ORF">PPYR_02744</name>
    </gene>
    <organism evidence="50 51">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="50 51" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="50">1611_PpyrPB1</strain>
            <tissue evidence="50">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>(2E)-butenoyl-[ACP] + NADPH + H(+) = butanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41812"/>
            <dbReference type="Rhea" id="RHEA-COMP:9627"/>
            <dbReference type="Rhea" id="RHEA-COMP:9628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78453"/>
            <dbReference type="ChEBI" id="CHEBI:78454"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:41813"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="46">
            <text>(2E)-decenoyl-[ACP] + NADPH + H(+) = decanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41864"/>
            <dbReference type="Rhea" id="RHEA-COMP:9639"/>
            <dbReference type="Rhea" id="RHEA-COMP:9640"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78467"/>
            <dbReference type="ChEBI" id="CHEBI:78468"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="46">
            <dbReference type="Rhea" id="RHEA:41865"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="30">
            <text>(2E)-dodecenoyl-[ACP] + NADPH + H(+) = dodecanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41880"/>
            <dbReference type="Rhea" id="RHEA-COMP:9643"/>
            <dbReference type="Rhea" id="RHEA-COMP:9644"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65264"/>
            <dbReference type="ChEBI" id="CHEBI:78472"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="30">
            <dbReference type="Rhea" id="RHEA:41881"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>(2E)-hexadecenoyl-[ACP] + NADPH + H(+) = hexadecanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41912"/>
            <dbReference type="Rhea" id="RHEA-COMP:9651"/>
            <dbReference type="Rhea" id="RHEA-COMP:9652"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78481"/>
            <dbReference type="ChEBI" id="CHEBI:78483"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:41913"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>(2E)-hexenoyl-[ACP] + NADPH + H(+) = hexanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41832"/>
            <dbReference type="Rhea" id="RHEA-COMP:9631"/>
            <dbReference type="Rhea" id="RHEA-COMP:9632"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78458"/>
            <dbReference type="ChEBI" id="CHEBI:78459"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:41833"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="39">
            <text>(2E)-octadecenoyl-[ACP] + NADPH + H(+) = octadecanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41928"/>
            <dbReference type="Rhea" id="RHEA-COMP:9655"/>
            <dbReference type="Rhea" id="RHEA-COMP:9656"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78489"/>
            <dbReference type="ChEBI" id="CHEBI:78495"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="39">
            <dbReference type="Rhea" id="RHEA:41929"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="32">
            <text>(2E)-octenoyl-[ACP] + NADPH + H(+) = octanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41848"/>
            <dbReference type="Rhea" id="RHEA-COMP:9635"/>
            <dbReference type="Rhea" id="RHEA-COMP:9636"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78462"/>
            <dbReference type="ChEBI" id="CHEBI:78463"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="32">
            <dbReference type="Rhea" id="RHEA:41849"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="41">
            <text>(2E)-tetradecenoyl-[ACP] + NADPH + H(+) = tetradecanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41896"/>
            <dbReference type="Rhea" id="RHEA-COMP:9647"/>
            <dbReference type="Rhea" id="RHEA-COMP:9648"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78475"/>
            <dbReference type="ChEBI" id="CHEBI:78477"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="41">
            <dbReference type="Rhea" id="RHEA:41897"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>(3R)-hydroxybutanoyl-[ACP] = (2E)-butenoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:41808"/>
            <dbReference type="Rhea" id="RHEA-COMP:9626"/>
            <dbReference type="Rhea" id="RHEA-COMP:9627"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78451"/>
            <dbReference type="ChEBI" id="CHEBI:78453"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:41809"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(3R)-hydroxydecanoyl-[ACP] = (2E)-decenoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:41860"/>
            <dbReference type="Rhea" id="RHEA-COMP:9638"/>
            <dbReference type="Rhea" id="RHEA-COMP:9639"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78466"/>
            <dbReference type="ChEBI" id="CHEBI:78467"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:41861"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(3R)-hydroxydodecanoyl-[ACP] = (2E)-dodecenoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:41876"/>
            <dbReference type="Rhea" id="RHEA-COMP:9642"/>
            <dbReference type="Rhea" id="RHEA-COMP:9643"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78470"/>
            <dbReference type="ChEBI" id="CHEBI:78472"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:41877"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>(3R)-hydroxyhexadecanoyl-[ACP] = (2E)-hexadecenoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:41908"/>
            <dbReference type="Rhea" id="RHEA-COMP:9650"/>
            <dbReference type="Rhea" id="RHEA-COMP:9651"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78480"/>
            <dbReference type="ChEBI" id="CHEBI:78481"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:41909"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(3R)-hydroxyhexanoyl-[ACP] = (2E)-hexenoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:41828"/>
            <dbReference type="Rhea" id="RHEA-COMP:9630"/>
            <dbReference type="Rhea" id="RHEA-COMP:9631"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78457"/>
            <dbReference type="ChEBI" id="CHEBI:78458"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:41829"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(3R)-hydroxyoctadecanoyl-[ACP] = (2E)-octadecenoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:41924"/>
            <dbReference type="Rhea" id="RHEA-COMP:9654"/>
            <dbReference type="Rhea" id="RHEA-COMP:9655"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78488"/>
            <dbReference type="ChEBI" id="CHEBI:78489"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:41925"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(3R)-hydroxyoctanoyl-[ACP] = (2E)-octenoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:41844"/>
            <dbReference type="Rhea" id="RHEA-COMP:9634"/>
            <dbReference type="Rhea" id="RHEA-COMP:9635"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78461"/>
            <dbReference type="ChEBI" id="CHEBI:78462"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:41845"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(3R)-hydroxytetradecanoyl-[ACP] = (2E)-tetradecenoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:41892"/>
            <dbReference type="Rhea" id="RHEA-COMP:9646"/>
            <dbReference type="Rhea" id="RHEA-COMP:9647"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78474"/>
            <dbReference type="ChEBI" id="CHEBI:78475"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:41893"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>3-oxobutanoyl-[ACP] + NADPH + H(+) = (3R)-hydroxybutanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41804"/>
            <dbReference type="Rhea" id="RHEA-COMP:9625"/>
            <dbReference type="Rhea" id="RHEA-COMP:9626"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78450"/>
            <dbReference type="ChEBI" id="CHEBI:78451"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="27">
            <dbReference type="Rhea" id="RHEA:41805"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>3-oxodecanoyl-[ACP] + NADPH + H(+) = (3R)-hydroxydecanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41856"/>
            <dbReference type="Rhea" id="RHEA-COMP:9637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9638"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78464"/>
            <dbReference type="ChEBI" id="CHEBI:78466"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:41857"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="42">
            <text>3-oxododecanoyl-[ACP] + NADPH + H(+) = (3R)-hydroxydodecanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41872"/>
            <dbReference type="Rhea" id="RHEA-COMP:9641"/>
            <dbReference type="Rhea" id="RHEA-COMP:9642"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78469"/>
            <dbReference type="ChEBI" id="CHEBI:78470"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="42">
            <dbReference type="Rhea" id="RHEA:41873"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="43">
            <text>3-oxohexadecanoyl-[ACP] + NADPH + H(+) = (3R)-hydroxyhexadecanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41904"/>
            <dbReference type="Rhea" id="RHEA-COMP:9649"/>
            <dbReference type="Rhea" id="RHEA-COMP:9650"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78478"/>
            <dbReference type="ChEBI" id="CHEBI:78480"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="43">
            <dbReference type="Rhea" id="RHEA:41905"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="34">
            <text>3-oxohexanoyl-[ACP] + NADPH + H(+) = (3R)-hydroxyhexanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41824"/>
            <dbReference type="Rhea" id="RHEA-COMP:9629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9630"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78456"/>
            <dbReference type="ChEBI" id="CHEBI:78457"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="34">
            <dbReference type="Rhea" id="RHEA:41825"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>3-oxooctadecanoyl-[ACP] + NADPH + H(+) = (3R)-hydroxyoctadecanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41920"/>
            <dbReference type="Rhea" id="RHEA-COMP:9653"/>
            <dbReference type="Rhea" id="RHEA-COMP:9654"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78487"/>
            <dbReference type="ChEBI" id="CHEBI:78488"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:41921"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="44">
            <text>3-oxooctanoyl-[ACP] + NADPH + H(+) = (3R)-hydroxyoctanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41840"/>
            <dbReference type="Rhea" id="RHEA-COMP:9633"/>
            <dbReference type="Rhea" id="RHEA-COMP:9634"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78460"/>
            <dbReference type="ChEBI" id="CHEBI:78461"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="44">
            <dbReference type="Rhea" id="RHEA:41841"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="38">
            <text>3-oxotetradecanoyl-[ACP] + NADPH + H(+) = (3R)-hydroxytetradecanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41888"/>
            <dbReference type="Rhea" id="RHEA-COMP:9645"/>
            <dbReference type="Rhea" id="RHEA-COMP:9646"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78473"/>
            <dbReference type="ChEBI" id="CHEBI:78474"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="38">
            <dbReference type="Rhea" id="RHEA:41889"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>a (3R)-hydroxyacyl-[ACP] + NADP(+) = a 3-oxoacyl-[ACP] + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17397"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="1.1.1.100"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="20">
            <dbReference type="Rhea" id="RHEA:17399"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a (3R)-hydroxyacyl-[ACP] = a (2E)-enoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:13097"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="4.2.1.59"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:13098"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="35">
            <text>a 2,3-saturated acyl-[ACP] + NADP(+) = a (2E)-enoyl-[ACP] + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22564"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9926"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78785"/>
            <dbReference type="EC" id="1.3.1.39"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="35">
            <dbReference type="Rhea" id="RHEA:22566"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="33">
            <text>a fatty acyl-[ACP] + malonyl-[ACP] + H(+) = a 3-oxoacyl-[ACP] + holo-[ACP] + CO2</text>
            <dbReference type="Rhea" id="RHEA:22836"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:14125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:138651"/>
            <dbReference type="EC" id="2.3.1.41"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="33">
            <dbReference type="Rhea" id="RHEA:22837"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>acetyl-[ACP] + malonyl-[ACP] + H(+) = 3-oxobutanoyl-[ACP] + holo-[ACP] + CO2</text>
            <dbReference type="Rhea" id="RHEA:41800"/>
            <dbReference type="Rhea" id="RHEA-COMP:9621"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9625"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78446"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78450"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="28">
            <dbReference type="Rhea" id="RHEA:41801"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="45">
            <text>butanoyl-[ACP] + malonyl-[ACP] + H(+) = 3-oxohexanoyl-[ACP] + holo-[ACP] + CO2</text>
            <dbReference type="Rhea" id="RHEA:41820"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9628"/>
            <dbReference type="Rhea" id="RHEA-COMP:9629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78454"/>
            <dbReference type="ChEBI" id="CHEBI:78456"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="45">
            <dbReference type="Rhea" id="RHEA:41821"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="40">
            <text>decanoyl-[ACP] + malonyl-[ACP] + H(+) = 3-oxododecanoyl-[ACP] + holo-[ACP] + CO2</text>
            <dbReference type="Rhea" id="RHEA:41868"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9640"/>
            <dbReference type="Rhea" id="RHEA-COMP:9641"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78468"/>
            <dbReference type="ChEBI" id="CHEBI:78469"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="40">
            <dbReference type="Rhea" id="RHEA:41869"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>dodecanoyl-[ACP] + malonyl-[ACP] + H(+) = 3-oxotetradecanoyl-[ACP] + holo-[ACP] + CO2</text>
            <dbReference type="Rhea" id="RHEA:41884"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9644"/>
            <dbReference type="Rhea" id="RHEA-COMP:9645"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:65264"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78473"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:41885"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="37">
            <text>hexadecanoyl-[ACP] + H2O = hexadecanoate + holo-[ACP] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41932"/>
            <dbReference type="Rhea" id="RHEA-COMP:9652"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78483"/>
            <dbReference type="EC" id="3.1.2.14"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="37">
            <dbReference type="Rhea" id="RHEA:41933"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>hexadecanoyl-[ACP] + malonyl-[ACP] + H(+) = 3-oxooctadecanoyl-[ACP] + holo-[ACP] + CO2</text>
            <dbReference type="Rhea" id="RHEA:41916"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9652"/>
            <dbReference type="Rhea" id="RHEA-COMP:9653"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78483"/>
            <dbReference type="ChEBI" id="CHEBI:78487"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="29">
            <dbReference type="Rhea" id="RHEA:41917"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>hexanoyl-[ACP] + malonyl-[ACP] + H(+) = 3-oxooctanoyl-[ACP] + holo-[ACP] + CO2</text>
            <dbReference type="Rhea" id="RHEA:41836"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9632"/>
            <dbReference type="Rhea" id="RHEA-COMP:9633"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78459"/>
            <dbReference type="ChEBI" id="CHEBI:78460"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:41837"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="36">
            <text>holo-[ACP] + acetyl-CoA = acetyl-[ACP] + CoA</text>
            <dbReference type="Rhea" id="RHEA:41788"/>
            <dbReference type="Rhea" id="RHEA-COMP:9621"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78446"/>
            <dbReference type="EC" id="2.3.1.38"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="36">
            <dbReference type="Rhea" id="RHEA:41789"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="47">
            <text>octanoyl-[ACP] + malonyl-[ACP] + H(+) = 3-oxodecanoyl-[ACP] + holo-[ACP] + CO2</text>
            <dbReference type="Rhea" id="RHEA:41852"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9636"/>
            <dbReference type="Rhea" id="RHEA-COMP:9637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78463"/>
            <dbReference type="ChEBI" id="CHEBI:78464"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="47">
            <dbReference type="Rhea" id="RHEA:41853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="31">
            <text>tetradecanoyl-[ACP] + H2O = tetradecanoate + holo-[ACP] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:30123"/>
            <dbReference type="Rhea" id="RHEA-COMP:9648"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30807"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78477"/>
            <dbReference type="EC" id="3.1.2.14"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="31">
            <dbReference type="Rhea" id="RHEA:30124"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>tetradecanoyl-[ACP] + malonyl-[ACP] + H(+) = 3-oxohexadecanoyl-[ACP] + holo-[ACP] + CO2</text>
            <dbReference type="Rhea" id="RHEA:41900"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9648"/>
            <dbReference type="Rhea" id="RHEA-COMP:9649"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78477"/>
            <dbReference type="ChEBI" id="CHEBI:78478"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:41901"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="caution">
        <text evidence="50">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0790944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A0U2"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019171">
        <property type="term" value="F:(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004313">
        <property type="term" value="F:[acyl-carrier-protein] S-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141148">
        <property type="term" value="F:enoyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016297">
        <property type="term" value="F:fatty acyl-[ACP] hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08954">
        <property type="entry name" value="KR_1_FAS_SDR_x"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049391">
        <property type="entry name" value="FAS_pseudo-KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF23">
        <property type="entry name" value="FATTY ACID SYNTHASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21149">
        <property type="entry name" value="FAS_pseudo-KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="2" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="51" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0702">S-nitrosylation</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="49">
        <location>
            <begin position="1"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="48">
        <location>
            <begin position="1713"/>
            <end position="1790"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00047394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00047440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00047451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00047500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00047578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00047810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00047897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00047953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00047961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00048051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00048281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00048289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="ARBA" id="ARBA00048420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="ARBA" id="ARBA00048506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="34">
        <source>
            <dbReference type="ARBA" id="ARBA00048571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="35">
        <source>
            <dbReference type="ARBA" id="ARBA00048650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="36">
        <source>
            <dbReference type="ARBA" id="ARBA00048691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="37">
        <source>
            <dbReference type="ARBA" id="ARBA00048704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="38">
        <source>
            <dbReference type="ARBA" id="ARBA00048935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="39">
        <source>
            <dbReference type="ARBA" id="ARBA00049019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="40">
        <source>
            <dbReference type="ARBA" id="ARBA00049109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="41">
        <source>
            <dbReference type="ARBA" id="ARBA00049171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="42">
        <source>
            <dbReference type="ARBA" id="ARBA00049263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="43">
        <source>
            <dbReference type="ARBA" id="ARBA00049414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="44">
        <source>
            <dbReference type="ARBA" id="ARBA00049422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="45">
        <source>
            <dbReference type="ARBA" id="ARBA00049449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="46">
        <source>
            <dbReference type="ARBA" id="ARBA00049521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="47">
        <source>
            <dbReference type="ARBA" id="ARBA00049533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="48">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="49">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="50">
        <source>
            <dbReference type="EMBL" id="KAB0790944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="51">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="2082" mass="232201" checksum="D45CE6EEB929159E" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A122</accession>
    <name>A0A5N4A122_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HIT-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_02823</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A122"/>
    <dbReference type="FunCoup" id="A0A5N4A122">
        <property type="interactions" value="238"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A122"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd23024">
        <property type="entry name" value="zf-HIT_ZNHIT2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007529">
        <property type="entry name" value="Znf_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039646">
        <property type="entry name" value="ZNHIT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15555">
        <property type="entry name" value="ZINC FINGER HIT DOMAIN CONTAINING PROTEIN 2 PROTEIN FON -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15555:SF0">
        <property type="entry name" value="ZINC FINGER HIT DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04438">
        <property type="entry name" value="zf-HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51083">
        <property type="entry name" value="ZF_HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HIT-type" evidence="2">
        <location>
            <begin position="9"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0791023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="184" mass="21091" checksum="5568326B30C3BF87" modified="2020-02-26" version="1">MDRISDDLCTFCKSTTKKYTCPQCQADYCSITCFQSTAHIECAESFYKSCVLENLPTGPYDDEEARQKLNEMFQRLRDYDEEDPLDSDDDEECESLATRLKNVDLDDTKEVWKRLTGDERQEFEAFLKSGDVSKLVPRWTPWWCPAKIQEVGELQKQSAPPLLENIAKFSSLTVTASILKASSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A1A3</accession>
    <name>A0A5N4A1A3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Sodium channel protein Nach</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PPYR_02848</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A1A3"/>
    <dbReference type="FunCoup" id="A0A5N4A1A3">
        <property type="interactions" value="26"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A1A3"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015280">
        <property type="term" value="F:ligand-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.470.10">
        <property type="entry name" value="Acid-sensing ion channels like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.770">
        <property type="entry name" value="YojJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF175">
        <property type="entry name" value="PICKPOCKET 13-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="4 12" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="10 12" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="447"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAB0791048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="498" mass="57652" checksum="7464151FE2DB0AAF" modified="2020-02-26" version="1">MHNTNGEIIVVTHEAIVSRERRSLNIHRPFETVNDFIGKTLSSPSFDKMQTTIREYLRNSSFHGIRYLAEQDRHWTERLFWLTCCVVSWFSSAMLMRAAWYDFHNNAVSFVVETNYLDWDTHFPTVAVCETDAQDNIAVASDALFGSPHDYNLDEMIAELVFFRGLAHYVLQLCSDTPHPDCFRYNYSFYETLVRQPCSTLFRKCKWNQEEFDCCKYFSKIETELGTCYAINSLQAKEKKPRIKMISNRRTGPGTFHLQLSGITDVYLLSHQDVPCLTTPKSDVIQVAPHIRFKRSIVLEEIVNQLEVRDVSVEQRNCRFPEESDLATYKYYSYSACNVECRKDAQLAKCNCTHHYMPNTDISKQCDIRGLECLNQHYNDLAVLRAHWANRPGLVCPCIPSCTDMEMTVIRDDKVGTHHDWASVEIHLERLPSERFKRTVVRGKLDLVVSMGGSVGLFVGASLLSFVEVFYYFTLRAIKKSNHEEKPEEPVEVLPYVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A1R7</accession>
    <name>A0A5N4A1R7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Lipase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PPYR_03074</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A1R7"/>
    <dbReference type="InParanoid" id="A0A5N4A1R7"/>
    <dbReference type="OrthoDB" id="9974421at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000179">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006693">
        <property type="entry name" value="AB_hydrolase_lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025483">
        <property type="entry name" value="Lipase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11005">
        <property type="entry name" value="LYSOSOMAL ACID LIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04083">
        <property type="entry name" value="Abhydro_lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000862">
        <property type="entry name" value="Steryl_ester_lip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024449238" description="Lipase" evidence="4">
        <location>
            <begin position="23"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="Partial AB-hydrolase lipase" evidence="5">
        <location>
            <begin position="39"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="337"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR000862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000862-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0791274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="392" mass="43759" checksum="8BA251F30E784271" modified="2020-02-26" version="1">MNFERLALCVALLLVQSPKNAGNWKIEGAKNSDGGPEALASRFGFLCESHQVTTEDGYILTLHRISGGKKMKTKPNGGGVLLLFPGLLASSETWLFRGADKDLPYVFADNGFDVWICNPRGNFFSRKHRSLDPDTDAHFWNYSIHEHGVFDLPASVDYALKVTKQNSLFFIGHSIGASAFFIMCSLKPEYNKKVRLATTLAAAAYVTRPVTPLTQILLSLVPLLSRAVTENGIYELFPRGGILSVVGQVLCRKGAITRSLCVSMVFAVVGRNNEQFNYTLFPEALNYYPSGSSFNVMTHLYDIFAARRFGPISGDTSEEYDMKMVTAPVALYYADGDALISKEDNELLAKRLPNVVGLFKVPYHNFNHIDFMWSIDSKILLYDRLVNLMKQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A1T1</accession>
    <name>A0A5N4A1T1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_03056</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A1T1"/>
    <dbReference type="InParanoid" id="A0A5N4A1T1"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008046">
        <property type="term" value="F:axon guidance receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050808">
        <property type="term" value="P:synapse organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000877">
        <property type="entry name" value="CLUMA_CG002357, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001233">
        <property type="entry name" value="Uncharacterized protein, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050958">
        <property type="entry name" value="Cell_Adh-Cytoskel_Orgn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080">
        <property type="entry name" value="CONTACTIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080:SF38">
        <property type="entry name" value="FI23916P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="37"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="128"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0791256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="362" mass="40387" checksum="54E97C16C352DD77" modified="2020-02-26" version="1">MDRVTPIAKITKTSSRCLSVSLTTSGFSDIFVSRIPPNLQIIPPENQVTAKQGGSVLFECQATGNPAPIVQWSKKDGILPSGLQVESGSTLSLNDLQKQHAGMYQCTASNGIGQPATSEVKLQVLYPPEVHVVRSWYNTGDSLEAKLSCLINADPPAEVLWYQNSFPLQPTDKRSITSSGTTSTLTIRNVQFSDFGNYSCVVLNSIGRDKKYIEISGKPGVAEIISPGFSNPNSYRLTWNVQSVFPIVEAKILFRRLLINTTYHHHDQWHDMIVRPNEVSFNSESTERLQQYQLNGLVADSVYECLIQTKSQYGYSELSNLHQWFTSRVGRQIESVGARLSSFFSTIVLLVVFIGYKIVYRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A1W3</accession>
    <name>A0A5N4A1W3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="30">Diacylglycerol lipase-alpha</fullName>
            <ecNumber evidence="21">3.1.1.116</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="32">Neural stem cell-derived dendrite regulator</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="31">Sn1-specific diacylglycerol lipase alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="35" type="ORF">PPYR_03107</name>
    </gene>
    <organism evidence="35 36">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="35 36" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="35">1611_PpyrPB1</strain>
            <tissue evidence="35">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>1,2-di-(9Z-octadecenoyl)-sn-glycerol + H2O = 2-(9Z-octadecenoyl)-glycerol + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38511"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:52333"/>
            <dbReference type="ChEBI" id="CHEBI:73990"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:38512"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>1-(9Z-octadecenoyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + H2O = 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38515"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:52392"/>
            <dbReference type="ChEBI" id="CHEBI:75449"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:38516"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>1-(9Z-octadecenoyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycerol + H2O = 2-(9Z,12Z-octadecadienoyl)-glycerol + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38523"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:75450"/>
            <dbReference type="ChEBI" id="CHEBI:75457"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:38524"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>1-(9Z-octadecenoyl)-2-O-(5Z,8Z,11Z,14Z-eicosatetraenyl)-sn-glycerol + H2O = 2-O-(5Z,8Z,11Z,14Z)-eicosatetraenylglycerol + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38527"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:75913"/>
            <dbReference type="ChEBI" id="CHEBI:75914"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="28">
            <dbReference type="Rhea" id="RHEA:38528"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycerol + H2O = 2-octadecanoylglycerol + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38519"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:75448"/>
            <dbReference type="ChEBI" id="CHEBI:75456"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:38520"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + H2O = 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + octadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38507"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:25629"/>
            <dbReference type="ChEBI" id="CHEBI:52392"/>
            <dbReference type="ChEBI" id="CHEBI:75728"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="27">
            <dbReference type="Rhea" id="RHEA:38508"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>a 1,2-diacyl-sn-glycerol + H2O = a 2-acylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33275"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17389"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.116"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:33276"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="29">Interacts (via C-terminal) with CAMK2A; leading to the phosphorylation and inhibition of DAGLA enzymatic activity. Interacts (via PPXXF motif) with HOMER1 and HOMER2; this interaction is required for DAGLA membrane localization.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Dendritic spine membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Early endosome membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="22">Postsynaptic density membrane</location>
            <topology evidence="22">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="35">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.116" evidence="21"/>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A1W3"/>
    <dbReference type="FunCoup" id="A0A5N4A1W3">
        <property type="interactions" value="467"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A1W3"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032591">
        <property type="term" value="C:dendritic spine membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098839">
        <property type="term" value="C:postsynaptic density membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004465">
        <property type="term" value="F:lipoprotein lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019369">
        <property type="term" value="P:arachidonate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046340">
        <property type="term" value="P:diacylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098921">
        <property type="term" value="P:retrograde trans-synaptic signaling by endocannabinoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000015">
        <property type="entry name" value="Sn1-specific diacylglycerol lipase alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052214">
        <property type="entry name" value="DAG_Lipase-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45792">
        <property type="entry name" value="DIACYLGLYCEROL LIPASE HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45792:SF8">
        <property type="entry name" value="DIACYLGLYCEROL LIPASE-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="19" id="KW-0966">Cell projection</keyword>
    <keyword evidence="9" id="KW-0967">Endosome</keyword>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="15" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="16 33" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="36" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0770">Synapse</keyword>
    <keyword evidence="7 33" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 33" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="33">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="33">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="33">
        <location>
            <begin position="96"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="33">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal lipase-type" evidence="34">
        <location>
            <begin position="398"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00024531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00026104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00037872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00048382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00050486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00050709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00050861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00052106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00052463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00063298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00071957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00081678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="ARBA" id="ARBA00082132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="34">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="35">
        <source>
            <dbReference type="EMBL" id="KAB0791307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="36">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="689" mass="78376" checksum="DC795F46003BFE1E" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A214</accession>
    <name>A0A5N4A214_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_03170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A214"/>
    <dbReference type="InParanoid" id="A0A5N4A214"/>
    <dbReference type="OrthoDB" id="6432525at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902936">
        <property type="term" value="F:phosphatidylinositol bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174">
        <property type="entry name" value="ALPHA-TOCOPHEROL TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174:SF213">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00180">
        <property type="entry name" value="CRETINALDHBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="79"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0791370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="297" mass="34512" checksum="296DC04BD0228FBC" modified="2020-02-26" version="1">MVATVEDEYKKNKELRADDMKALQEWVRKQPHLPHVSDFQLALFLHSCHFSMEQAKVTIEKFFTYRGAWGDFFANRDPRDPKLQNDMKVSLCSFLPERTPENYKLLYFKLVDVDVNKYAVSDCVKLFDMAISLEFMERGSFDGLVIVVDLKAFTVGHVLKTHITTMKRILLYVQEAIPIRLKGLHYITLASVCDLLVPLVKPFMKKELAHLLHFHDSYETLSKFVPHELLPEDYGGKAPSVKELHAKMQESFTENADFFLDEEMLVSNEKLRDRKQSYMDRDLGIGTDGSFKKLDFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A4L1</accession>
    <name>A0A5N4A4L1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transcription initiation factor TFIID subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PPYR_14168</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">1611_PpyrPB1</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the TAF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A5N4A4L1">
        <property type="interactions" value="1964"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A4L1"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05511">
        <property type="entry name" value="Bromo_TFIID"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.10:FF:000020">
        <property type="entry name" value="Transcription initiation factor TFIID subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.10:FF:000039">
        <property type="entry name" value="Transcription initiation factor TFIID subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1100.10">
        <property type="entry name" value="TAFII-230 TBP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040240">
        <property type="entry name" value="TAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011177">
        <property type="entry name" value="TAF1_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022591">
        <property type="entry name" value="TAF1_HAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009067">
        <property type="entry name" value="TAF_II_230-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036741">
        <property type="entry name" value="TAFII-230_TBP-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041670">
        <property type="entry name" value="Znf-CCHC_6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13900">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13900:SF0">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12157">
        <property type="entry name" value="DUF3591"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09247">
        <property type="entry name" value="TBP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15288">
        <property type="entry name" value="zf-CCHC_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003047">
        <property type="entry name" value="TAF1_animal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47055">
        <property type="entry name" value="TAF(II)230 TBP-binding fragment"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Bromo" evidence="14">
        <location>
            <begin position="1408"/>
            <end position="1478"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="14">
        <location>
            <begin position="1530"/>
            <end position="1600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="115"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="188"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="358"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="935"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1099"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1241"/>
            <end position="1269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1833"/>
            <end position="1871"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="1178"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="1485"/>
            <end position="1512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="195"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="208"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="246"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="362"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="940"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1099"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1242"/>
            <end position="1260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1849"/>
            <end position="1858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="1859"/>
            <end position="1871"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR003047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAB0792209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1871" mass="213505" checksum="30185DF16084CBB9" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-06-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A622</accession>
    <name>A0A5N4A622_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_14724</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A622"/>
    <dbReference type="InParanoid" id="A0A5N4A622"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0792765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="102" mass="11290" checksum="F4007E00E8A3995D" modified="2020-02-26" version="1">MDQALMENDLDTTSCMQKMVCYTVRESSNKVSNGLASSKDKIIDGIVTNEWISKLFDGTPVQSAIRSGLDGVNCSNEYSLCKLEQKTFANLVRQFANTINLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A6H4</accession>
    <name>A0A5N4A6H4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protein sleepless</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_12542</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0792922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A6H4"/>
    <dbReference type="InParanoid" id="A0A5N4A6H4"/>
    <dbReference type="OrthoDB" id="6725625at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050975">
        <property type="entry name" value="Sleep_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33562">
        <property type="entry name" value="ATILLA, ISOFORM B-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33562:SF29">
        <property type="entry name" value="PROTEIN SLEEPLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024456559" description="Protein sleepless" evidence="8">
        <location>
            <begin position="23"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0792922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="163" mass="18385" checksum="9B6D29238F9D6ACC" modified="2020-02-26" version="1">MTVYASPVCFLIAIAFAQTALALHCYTCQTQSPNQTCFTHINTTRIPSKLCNRSSADLSIFFNLEHVNPTYLLEASNSSEFECVSYTKTYLRQNITRVGRGCFPKTPNLNVCQAMFFVQGGDAFNLTQCDTCDQDNCNKSVSIYQSYRLLCAVFLVAHYFFNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A6Q8</accession>
    <name>A0A5N4A6Q8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aromatic amino acid beta-eliminating lyase/threonine aldolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_12627</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the threonine aldolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A6Q8"/>
    <dbReference type="FunCoup" id="A0A5N4A6Q8">
        <property type="interactions" value="112"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A6Q8"/>
    <dbReference type="OrthoDB" id="10261951at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008732">
        <property type="term" value="F:L-allo-threonine aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006545">
        <property type="term" value="P:glycine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:L-threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06502">
        <property type="entry name" value="TA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000030">
        <property type="entry name" value="Low-specificity L-threonine aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000041">
        <property type="entry name" value="Low-specificity L-threonine aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001597">
        <property type="entry name" value="ArAA_b-elim_lyase/Thr_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023603">
        <property type="entry name" value="Low_specificity_L-TA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041359">
        <property type="entry name" value="GntG_guanitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007825">
        <property type="entry name" value="PRK10534.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48097:SF9">
        <property type="entry name" value="L-THREONINE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48097">
        <property type="entry name" value="L-THREONINE ALDOLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01212">
        <property type="entry name" value="Beta_elim_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017617">
        <property type="entry name" value="Thr_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aromatic amino acid beta-eliminating lyase/threonine aldolase" evidence="6">
        <location>
            <begin position="23"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR017617-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0793007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="381" mass="41772" checksum="31D864D26D3FE93D" modified="2020-02-26" version="1">MPYNFEEYSECGHVEGTIAHVVDLRSDTITKPTVEMRKAMAVAEVGDDVFGEDPTVNELERRSAELMGKEDGIFLSSGTMCNIIAVMVHCNKRSVEFIAGDKSHLHLFEQGGPAVLAGVQSSIVTNNPDGTFSLEEMESKIRTSNDSHETSTALIVVENTHNLCGGRVLPLEWLDKLAKIAANYNLPLHMDGARIMNAVVKSKVSAKRIARDMDSVCFCLSKGLSCPVGSVLCGSKSFIKQARRFRKLLGGGMRQVGILAAAGLVALDEMIDRLHIDHDHAYKVAKAISDLDSDIVRVDLSAVETNIVNIHLDTAKISSKAFLEQLAKITKTEEVSVKALSFSPSSIRLVFHWEISHNDVAGVIRKMRFVIKGLHVGRYIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A7G4</accession>
    <name>A0A5N4A7G4_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_12894</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A7G4"/>
    <dbReference type="InParanoid" id="A0A5N4A7G4"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33053">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0793274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="281" mass="31033" checksum="6A4E1BE79B1246B9" modified="2020-02-26" version="1">MSKRRKLPFKLLSARSQRRRMYDTDDEDDSTNLSNADKDIETVSLSDDQKAIHSESVTRSMHNQSAFDSNLDSNFETSQTSSNLLATSVSSSSPSSNMLKLSSTDSESSTASLFDVESNTNPKTELEDITIFLQEWALNTNCTTSALSSLLVGLKKHSCFSRLPTDGRTLLKVKRLLSSKPVDPGQYVHIGLKHQLKVIFEPLTSLSITTIDLLINIDGLPLFKSSPGQLIPILFSIPTIVQLKGQVFPLGFYYGLQKPKSMSAFLNDFVTEAVDLIQNGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A8N2</accession>
    <name>A0A5N4A8N2_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Thaumatin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_13295</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A8N2"/>
    <dbReference type="InParanoid" id="A0A5N4A8N2"/>
    <dbReference type="OrthoDB" id="430315at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09218">
        <property type="entry name" value="TLP-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.110.10:FF:000004">
        <property type="entry name" value="THAUMATIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.110.10">
        <property type="entry name" value="Thaumatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037176">
        <property type="entry name" value="Osmotin/thaumatin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001938">
        <property type="entry name" value="Thaumatin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31048">
        <property type="entry name" value="OS03G0233200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00314">
        <property type="entry name" value="Thaumatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002703">
        <property type="entry name" value="Thaumatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00347">
        <property type="entry name" value="THAUMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00205">
        <property type="entry name" value="THN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49870">
        <property type="entry name" value="Osmotin, thaumatin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51367">
        <property type="entry name" value="THAUMATIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024386519" description="Thaumatin-like protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="77"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="87"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="141"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="146"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="154"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="175"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="185"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR002703-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0793675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="240" mass="26187" checksum="88E5DC902E5E33C4" modified="2020-02-26" version="1">MAFKLSLLIVASFQIVTIHSVQFVIQNNIPGPIEVGIQGNAGHPHLHNGGFPLNPGQEITIDAPNEWAGRFWAKTWCVNGHCQTGDCGGRVECAGAGGVPPVTLVEITLRGAGNQDFYDVSLVDGFNVLASITPENGQGKCESVWCSFNLNQGCPNDLKKIGGNGNDVVGCYSSCLKYNTDQFCCRGTFNNPQTCKPENMPQPNSAGYFKHFCPRYYSYAYDDPTSTFTCLANRYRISFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A9A8</accession>
    <name>A0A5N4A9A8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Condensin complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PPYR_13458</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CND2 (condensin subunit 2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A9A8"/>
    <dbReference type="FunCoup" id="A0A5N4A9A8">
        <property type="interactions" value="958"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A9A8"/>
    <dbReference type="OrthoDB" id="362021at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022816">
        <property type="entry name" value="Condensin_barren_su2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13108">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13108:SF9">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05786">
        <property type="entry name" value="Cnd2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="8" id="KW-0498">Mitosis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="163"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="174"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAB0793838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="681" mass="77556" checksum="0B832F29A0CEFCC9" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A9R1</accession>
    <name>A0A5N4A9R1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_13667</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0794047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A9R1"/>
    <dbReference type="InParanoid" id="A0A5N4A9R1"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050382">
        <property type="entry name" value="MFS_Na/Anion_cotransporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662:SF77">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY TRANSPORTER 17, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="124"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="161"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="8"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0794047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="342" mass="37540" checksum="F513288392C5547F" modified="2020-02-26" version="1">MIPARVELYILALLVITVTTFNLNVASTTIVSMVKEFYMRVPETDELNACHKRVNASTNNGGSLEWSGDVQFLFLTSPYLGYVVVQTLGGYATQRFGTKKVIGCSLLTISACNLVLPIGCKVHYSFAIVLQFVQGFAQGGIWPGLFGIIPYWIPLRERSRFGSCFQGSAIGAMSAQFIARLATPSIGWEYIFVVAAFVGLIMSLGWFLLACNEPELHPRITLDELDYIKKHQQVLPPYRDKIPWGSMVGSLPLWAILFSAFGRAWFGNTIGISGPLYLKAEIGLDDGSIGDFSGAIHFASFLTGLIFAYIADRLLIEDVVGVLANRRLLLGIGKYRANGSIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ABX8</accession>
    <name>A0A5N4ABX8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_11669</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0794830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4ABX8"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.70:FF:000004">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000063">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000026">
        <property type="entry name" value="Transposon Ty3-G Gag-Pol polyprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF8">
        <property type="entry name" value="CCHC-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="3">
        <location>
            <begin position="490"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="4">
        <location>
            <begin position="1034"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="213"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0794830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1356" mass="154848" checksum="DF47FDCD0564C629" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ACX3</accession>
    <name>A0A5N4ACX3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_12001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0795162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ACX3"/>
    <dbReference type="FunCoup" id="A0A5N4ACX3">
        <property type="interactions" value="521"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4ACX3"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043183">
        <property type="entry name" value="DNJB2/6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45168:SF3">
        <property type="entry name" value="DNAJ HEAT SHOCK PROTEIN FAMILY (HSP40) MEMBER B2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45168">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="3"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0795162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="275" mass="31503" checksum="31BC40D44D0E0B74" modified="2020-02-26" version="1">MVDYYKVLDVPRGASTADIKKAYRKLALKWHPDKNPNNSEDATKKFKEISEAYEVLSDESKRKIYDNRFYQRASTNKSSRSFRSYFDTHTPFHRSFEKKRRVYDQYGKEGLMSGATRSRTRHDDDFDLGFGFFTFRDPEDVFREFFGSPVSDLLADLHGHHDHRGRRGNRHSHPQNAVSSTIFNPFGFGLGFGNSLMDDLFHNGSPGFSSFSSSFSNGTNGHTNIKKTSTSTRFIDGKKITTKKVYENGKETVVTYENDVMKSKTVNGVPQSLTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AE31</accession>
    <name>A0A5N4AE31_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Caspase-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PPYR_12415</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase C14A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0795576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AE31"/>
    <dbReference type="FunCoup" id="A0A5N4AE31">
        <property type="interactions" value="1053"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AE31"/>
    <dbReference type="OrthoDB" id="6116485at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990525">
        <property type="term" value="F:BIR domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045751">
        <property type="term" value="P:negative regulation of Toll signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016322">
        <property type="term" value="P:neuron remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045476">
        <property type="term" value="P:nurse cell apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043525">
        <property type="term" value="P:positive regulation of neuron apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00032">
        <property type="entry name" value="CASc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1460:FF:000001">
        <property type="entry name" value="Caspase-3 preproprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033139">
        <property type="entry name" value="Caspase_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016129">
        <property type="entry name" value="Caspase_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002398">
        <property type="entry name" value="Pept_C14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002138">
        <property type="entry name" value="Pept_C14_p10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001309">
        <property type="entry name" value="Pept_C14_p20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015917">
        <property type="entry name" value="Pept_C14A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10454">
        <property type="entry name" value="CASPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10454:SF245">
        <property type="entry name" value="CASPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00376">
        <property type="entry name" value="IL1BCENZYME"/>
    </dbReference>
    <dbReference type="SMART" id="SM00115">
        <property type="entry name" value="CASc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01122">
        <property type="entry name" value="CASPASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01121">
        <property type="entry name" value="CASPASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50207">
        <property type="entry name" value="CASPASE_P10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50208">
        <property type="entry name" value="CASPASE_P20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="6" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Caspase family p20" evidence="9">
        <location>
            <begin position="51"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Caspase family p10" evidence="8">
        <location>
            <begin position="192"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0795576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="327" mass="37250" checksum="62B5D0B615542E3D" modified="2020-02-26" version="1">MAEENDGNCIGNSNKNDEKDALSNSKAFYQPCIAKMPTERNAPYYNMNHKNRGVAIVFNHEHFDIGGLSRRSGTNVDCECLVIRLKTLGFDVQVFHNLEYSHLYARVSAAADLDHCDNDCFIMVILTHGELGILYAKDSAYKPENLWMPFTADKCPSLAGKPKLFFIQACQGDRLDPGVTLNRTETDGHPWSSYRIPTHADFLLVYSTIPGYYSWRNTAKGSWFIQALCTELDESCELYDLLTLLTFVSRRVAVDYESNVPTDTRMHLQKQIPCITSMLIRLLKLNKKGVNQLENEGQDTKSREKFKNSFSSMFQGRGKTNSYRINY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AF55</accession>
    <name>A0A5N4AF55_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF243 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_10000</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0795939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AF55"/>
    <dbReference type="FunCoup" id="A0A5N4AF55">
        <property type="interactions" value="35"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AF55"/>
    <dbReference type="OrthoDB" id="6376010at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062129">
        <property type="term" value="C:chitin-based extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008010">
        <property type="term" value="F:structural constituent of chitin-based larval cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040003">
        <property type="term" value="P:chitin-based cuticle development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004145">
        <property type="entry name" value="DUF243"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31927">
        <property type="entry name" value="FI07246P-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31927:SF13">
        <property type="entry name" value="TWEEDLEBETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03103">
        <property type="entry name" value="DUF243"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00690">
        <property type="entry name" value="DM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024397834" description="DUF243 domain-containing protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="DUF243" evidence="3">
        <location>
            <begin position="111"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="254"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0795939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="298" mass="29960" checksum="DA8E8475510A6F55" modified="2020-02-26" version="1">MKFVTVILSLVAVINARPDVSHLPTGSYLPSGHLGESSGQFGSISSLGGQFGGGQTSFGGGQASLGGLGGQSSFGQTSFGSQSTFGGGSYEGHTGGIGVGGIGVGGGFQDQKHVYFFAAPEEESSGRLRIQIVPNSQRNTKIIFVKAPSYGAVQPEVIAPPSISEDKTLVYVLVKRPDHGGSISIPAGAGVKASKPEVYFIKYKSQQDARQLISGGLQGQQVGANVPDLGNEASFVRTLDSGVSNVGLGSTSFTSGTSQGTSIGSIGSHTSGSHSSGIFTSGTSGSSQYGPAGASGPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AFB3</accession>
    <name>A0A5N4AFB3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed DNA polymerase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_10065</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AFB3"/>
    <dbReference type="InParanoid" id="A0A5N4AFB3"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.60">
        <property type="entry name" value="N-acetyl transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511">
        <property type="entry name" value="PROTEIN CBG23764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511:SF12">
        <property type="entry name" value="RHO TERMINATION FACTOR N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="His-Me finger endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0796004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1031" mass="119346" checksum="0546E55D2D870C93" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AFW7</accession>
    <name>A0A5N4AFW7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PPYR_10265</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Trehalose transporter subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AFW7"/>
    <dbReference type="InParanoid" id="A0A5N4AFW7"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000055">
        <property type="entry name" value="Facilitated trehalose transporter Tret1-2 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050549">
        <property type="entry name" value="MFS_Trehalose_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021:SF46">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="294"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="352"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="391"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="419"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="14"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0796204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="463" mass="51346" checksum="DA0CFA5B6C30ABCE" modified="2020-02-26" version="1">MRVTSSIYKREYRLQYLATFAGTLSILSVGANNAWTSPYLPQITNGTYPGISVTSDEGSWIAIMPQLASPPGALIAAYLVDRIGRKMTTLLMAPITFAMFITMAFARTTLAFCAIRFLIGCVGSILYTALPMYLGEIAHPAIRGILTASVAFSSLLGTLLINVLGFHFSILLSSLICAAIPLVHFLAFIWMPESPYYLIRKNMDETARESLAKLRSTDDNGNEFKMISVAVNEEIANKKARFLDIFTVKSNRFALFVFIILNTTRKFSGIGPFLFYTVSIFQTAEGSVSPHTSVVIFLCIQIISAMVSLNVLDYVGRRPIIIISTVACIITLSISGTYFYCKEYHPDYLQHFGWVPLTVLTIYMVFYNLGLELTPMVYASELFPTNVKASALGVVDVISSCNGIVTLKLFHILTDHYGMYLSFWVFAVCCVVGLVLIVIYVPETKNKTLQEIQQDLSGRSEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AGC9</accession>
    <name>A0A5N4AGC9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PPYR_10424</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 9 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AGC9"/>
    <dbReference type="InParanoid" id="A0A5N4AGC9"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000085">
        <property type="entry name" value="SIX homeobox 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031701">
        <property type="entry name" value="SIX1_SD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10390">
        <property type="entry name" value="HOMEOBOX PROTEIN SIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10390:SF44">
        <property type="entry name" value="SIX HOMEOBOX 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16878">
        <property type="entry name" value="SIX1_SD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5 9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0371">Homeobox</keyword>
    <keyword evidence="8 9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="11">
        <location>
            <begin position="115"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="9">
        <location>
            <begin position="117"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAB0796363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="217" mass="25203" checksum="4CEE03097B6F30A1" modified="2020-02-26" version="1">MCEALHQRGDVERLATFLWSLPPSELLRGNESILRARAVVAFHRGSFHELYAILESHSFNPRWHTDLQNLWFRAHYNEAEKIRGRPLGAVDKYRLRKKYPLPKTIWDGEETVYCFKERSRNALKECYARNKYPTPDEKRALAKRTGLTLTQVSNWFKNRRQRDRTPQSRPELLMSNLSLGSANGLTGHQGGIELSTFPAKLFDPSCTLSSCYNDYQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-06-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AGS4</accession>
    <name>A0A5N4AGS4_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_10550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AGS4"/>
    <dbReference type="InParanoid" id="A0A5N4AGS4"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0796489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="138" mass="15176" checksum="3DFDE64C7497207F" modified="2020-02-26" version="1">MKSHSDKSHPPANIGDNVMIPIPDVDKSKVDLRNIIGVVIDITDEGLYKVGTKHGILQTLYCRTQFDVSAQRFITENDVNMESEISLRTAATKHSIGSGQGFLKCSCTTSCKTNRCLCKKKNVLCNSKCHSSLSCNNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AGS7</accession>
    <name>A0A5N4AGS7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">GTP-binding protein Di-Ras2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PPYR_10547</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the small GTPase superfamily. RasD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AGS7"/>
    <dbReference type="FunCoup" id="A0A5N4AGS7">
        <property type="interactions" value="84"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AGS7"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000475">
        <property type="entry name" value="GTP-binding protein Rhes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052236">
        <property type="entry name" value="Small_GTPase_RasD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46149:SF7">
        <property type="entry name" value="GTP-BINDING PROTEIN DI-RAS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46149">
        <property type="entry name" value="MIP08469P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0636">Prenylation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="184"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="192"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="205"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="220"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0796486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="251" mass="28348" checksum="274F04C921610110" modified="2020-02-26" version="1">MNNNGTTMSDYERIRIVILGGADKYRSTVEDLYNREYDLGHMTLKVDILDTAGDMQFPAMRRLCIATAHAFLLVYAVTSAPSFTCIKQCFEEIREQRADFQDVPIVVAGNKLDLTTTHREVRIEDVSEWVYCELPKLRVKVLEVSAKDDINVKEIFRSFLTLSRIFPKDADEITGLKRRSSAYVSASSKGGRRTESPALEKEKTSSAGEGSNSLGESRAKPRSRSLIRRSSRKTKQQIRDAHNTTEECIVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AHJ4</accession>
    <name>A0A5N4AHJ4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_10834</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AHJ4"/>
    <dbReference type="InParanoid" id="A0A5N4AHJ4"/>
    <dbReference type="OrthoDB" id="348005at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003341">
        <property type="term" value="P:cilium movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036159">
        <property type="term" value="P:inner dynein arm assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036158">
        <property type="term" value="P:outer dynein arm assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052004">
        <property type="entry name" value="Dynein_assembly_factor_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46492">
        <property type="entry name" value="DYNEIN ASSEMBLY FACTOR 4, AXONEMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46492:SF1">
        <property type="entry name" value="DYNEIN AXONEMAL ASSEMBLY FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="1">
        <location>
            <begin position="3"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0796773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="383" mass="44315" checksum="0DB51E07D70F7EB8" modified="2020-02-26" version="1">MPLIVKDYKWRQSDNFVIIQVPLHGVHQSKVDLFTSPVYIKASFEKFFFEAFLLRSVNTAESKCTKTASEIVFELAKNENIEWESLEVDLSKAERLKLKKGIIEEEHLRFQEECKKKSDNKSELKRVAVREQISLDSKIRNKIEEIKVEEKSKALGDVRAWERSVEKSAPRIVKGSKKLQKSTLVPLPRKIATVHVDFTHRQFPTPCRESHLAEEEEWLRKQAEVRRSVGFVSEDLRAEEKNPQWLNAKGQEFLKAGNYLGAISAFSFAIKLCSEYPDLYIGRSEAHFYKENYFKCAQDCSSAVELLRPAVPSNLEQRVTCLTRKGLALRKMGFLRECINELEFALKLKPENQEVRDVLVDIKTELANQEENDEKNSNQLQTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AIA3</accession>
    <name>A0A5N4AIA3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylesterase type B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_11105</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0797044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AIA3"/>
    <dbReference type="InParanoid" id="A0A5N4AIA3"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051093">
        <property type="entry name" value="Neuroligin/BSAL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43903">
        <property type="entry name" value="NEUROLIGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="3">
        <location>
            <begin position="10"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0797044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="491" mass="54942" checksum="FC15595700AB1C2E" modified="2020-02-26" version="1">MRNRGLEAPYAVLVFAHGESFEWGSGNPYDGSVLASYGHVIVVTLNFRLGILGFLKTRVGVDTSDSSGGNLGIKDIAAALRWIKANIASFGGDHKRVTLIGHDTGAALANFLLVSPKSKGLFQRVVLLSGAALSPWATIHNPDSIRISVGQQTGCLSSAEGEDEDIAPCLRSRPVQALLDVNIEIVRFMPRIAPSLPIDLETPDPEYSMEHASENFITCEVLLGTTTTESYNDFSATDIQYGFEEEERNRVLRTYIRNAYVYHLNEIFSAVRNEYTDWDKPIQHPINIRDSTMEALSDGHTVSPLIRVGYLHARRGAKTYFFHFGYQTKDSDYPQRLGSVRGKDLTYILGMPLVGGMPFFPQNFSRQDMGVAEAVLNFFSNFAKSGDPNGPGVHKDIPDYGTPREKTRYRGLTWEPYEIGTQLYLSVALKPKMKSHYRGHKMAVWLNLIPQLHQPGDDDVSMRHHHFHEREQYYYAGTGTKLFLFLIISGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AKG0</accession>
    <name>A0A5N4AKG0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxylesterase type B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_08800</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AKG0"/>
    <dbReference type="InParanoid" id="A0A5N4AKG0"/>
    <dbReference type="OrthoDB" id="19653at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00312">
        <property type="entry name" value="Esterase_lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142:SF1">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024426214" description="Carboxylesterase type B domain-containing protein" evidence="5">
        <location>
            <begin position="19"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="6">
        <location>
            <begin position="24"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0797807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="561" mass="63210" checksum="306AF1A624FDEAF9" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AKX5</accession>
    <name>A0A5N4AKX5_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_08949</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AKX5"/>
    <dbReference type="InParanoid" id="A0A5N4AKX5"/>
    <dbReference type="OrthoDB" id="8015657at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.180.10.10">
        <property type="entry name" value="RHS repeat-associated core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="328"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="414"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="693"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="7"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="328"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="430"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="480"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="693"/>
            <end position="718"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0797956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="745" mass="85656" checksum="EF920284295BAF2B" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AMI8</accession>
    <name>A0A5N4AMI8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_09558</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AMI8"/>
    <dbReference type="InParanoid" id="A0A5N4AMI8"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF269">
        <property type="entry name" value="NUCLEASE HARBI1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="8">
        <location>
            <begin position="37"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0798565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="277" mass="31910" checksum="D95A8C98154C2792" modified="2020-02-26" version="1">MLVSFFVYVTKSQDGWERVSQEFEEQWNFPNCLGSADGKHVAIQKPPNSGSYYYNYKGYFSIVLMAVVDANYKFLMVDVGANGRVSDGGVMKNTLFWRKLSENQLNLPDPRQLPGTSKKCPYVFLGDEAFQLHPNFMKPYNRAALTNDKTIYNYRLSRARRVVENAFGILTKRFKIFQKPIKFEPLKVRKIVMTCCHLHNYLCSKNRANYLPPQNIDNEDVTTGAKELGSWRQDTPQMLFLQKTKGNATVLAKTVRDDFCEFFNTSGAVPWQNKCLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4APJ2</accession>
    <name>A0A5N4APJ2_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PPYR_07152</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A5N4APJ2">
        <property type="interactions" value="46"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4APJ2"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17094">
        <property type="entry name" value="FERM_F1_Max1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00821">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13282">
        <property type="entry name" value="PH1_PLEKHH1_PLEKHH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000286">
        <property type="entry name" value="PH-protein kinase domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.530">
        <property type="entry name" value="MyTH4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002404">
        <property type="entry name" value="IRS_PTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000857">
        <property type="entry name" value="MyTH4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038185">
        <property type="entry name" value="MyTH4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22903:SF8">
        <property type="entry name" value="MAX-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22903">
        <property type="entry name" value="PLEKHH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02174">
        <property type="entry name" value="IRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00784">
        <property type="entry name" value="MyTH4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21989">
        <property type="entry name" value="RA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00139">
        <property type="entry name" value="MyTH4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51016">
        <property type="entry name" value="MYTH4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PH" evidence="10">
        <location>
            <begin position="488"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="10">
        <location>
            <begin position="596"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="domain" description="MyTH4" evidence="12">
        <location>
            <begin position="741"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="domain" description="FERM" evidence="11">
        <location>
            <begin position="980"/>
            <end position="1364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="212"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="382"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1146"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1404"/>
            <end position="1427"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="90"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="396"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="419"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1406"/>
            <end position="1417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAB0799272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1427" mass="159211" checksum="E7A2A9462ED9A6B4" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4APR4</accession>
    <name>A0A5N4APR4_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_07197</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4APR4"/>
    <dbReference type="InParanoid" id="A0A5N4APR4"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23992">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.20">
        <property type="entry name" value="Pheromone/general odorant binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006170">
        <property type="entry name" value="PBP/GOBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036728">
        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01395">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024399842" evidence="1">
        <location>
            <begin position="20"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0799317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="142" mass="16371" checksum="4C14116521C4298E" modified="2020-02-26" version="1">MYLVLIGTVLLITHPIAMFQTTVYGLPLNEKERACAEKHNLSTKNIEMWNIEPLIPEDNVEMLEYMSCYWKNLGYLTEDGEIDFVKLGDVVHADLNARFHAEFGHIVAFIMDNCKQTVHGETDGLRAVKMWNCLNVYTENLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4APT8</accession>
    <name>A0A5N4APT8_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_07214</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4APT8"/>
    <dbReference type="InParanoid" id="A0A5N4APT8"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0799334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="231" mass="26228" checksum="A88B7C59851C3068" modified="2020-02-26" version="1">MPRLPERFLPCELHHAAPRVKLLLSEYSIALYERLGTSSNHQLQKLSNDDLSTPFIPGQHISFRDRRIGAPKFSHGVILEALGHRMYRLRDDDGEEHIRNKGQLHPGPPPRRRRQAKSSPSSTNTALLLWDDEHSEQVTQQSSSSPREEPRVSDTSEPAPLIPTEDDISDLRPPSFTQPDCSQNSKHESRFPMATENQSPLAAPRPLRPARDVQAPAWIRSGEYEIYLPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AQT9</accession>
    <name>A0A5N4AQT9_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_07513</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AQT9"/>
    <dbReference type="FunCoup" id="A0A5N4AQT9">
        <property type="interactions" value="95"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AQT9"/>
    <dbReference type="OrthoDB" id="6595846at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007608">
        <property type="term" value="P:sensory perception of smell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23992">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.20">
        <property type="entry name" value="Pheromone/general odorant binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006170">
        <property type="entry name" value="PBP/GOBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036728">
        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11857:SF42">
        <property type="entry name" value="GENERAL ODORANT-BINDING PROTEIN 19D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11857">
        <property type="entry name" value="ODORANT BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01395">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00708">
        <property type="entry name" value="PhBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024396822" evidence="2">
        <location>
            <begin position="17"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0799633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="147" mass="16176" checksum="0E157E6F3CE60896" modified="2020-02-26" version="1">MKSLIILPFLLSAIFCLNPQMEEMIRTRVKENGLICMSKIGATDGDVAPLVNHQVPTTEAGKCFLACMYKTEGFIGADGSINREGSLAAIEPMKDMDQDYYLKVKQVMENCLDKISNGDNECETAVIVHQCVLAEKENVGLPAIEMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-06-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ART7</accession>
    <name>A0A5N4ART7_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_07921</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0800041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ART7"/>
    <dbReference type="InParanoid" id="A0A5N4ART7"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0800041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="101" mass="11545" checksum="6BB6215637DA6930" modified="2020-02-26" version="1">MNDIEKNNAPNSNSEYFLQDMPFHIVGVVVTKIRDANILSKTSKRKINVHFPMHHPHMLSGPPRPSAPVCPSLKNKGMLCFQTHHTQTHEIYAVFLLLHFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AS92</accession>
    <name>A0A5N4AS92_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Cytochrome b-c1 complex subunit 8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Complex III subunit 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PPYR_07968</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The complex plays an important role in the uptake of multiple carbon sources present in different host niches.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12 13">Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 11 subunits. The complex is composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein UQCRFS1, 2 core protein subunits UQCRC1/QCR1 and UQCRC2/QCR2, and 6 low-molecular weight protein subunits UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and subunit 9, the cleavage product of Rieske protein UQCRFS1. The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and cytochrome c oxidase (complex IV, CIV), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)). Interacts with UQCC6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Mitochondrion inner membrane</location>
            <topology evidence="1 13">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the UQCRQ/QCR8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0800088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AS92"/>
    <dbReference type="FunCoup" id="A0A5N4AS92">
        <property type="interactions" value="462"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AS92"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045275">
        <property type="term" value="C:respiratory chain complex III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.210:FF:000001">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.210">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004205">
        <property type="entry name" value="Cyt_bc1_su8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036642">
        <property type="entry name" value="Cyt_bc1_su8_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12119:SF2">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12119">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX UBIQUINONE-BINDING PROTEIN QP-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02939">
        <property type="entry name" value="UcrQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81508">
        <property type="entry name" value="Ubiquinone-binding protein QP-C of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0249">Electron transport</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 13" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU368118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAB0800088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="82" mass="9726" checksum="D7FBA5E801DA632E" modified="2020-02-26" version="1">MGKSFGELYKLRGIITYRLSPFEQRAFAFAISKGVPNMFRRIREEIFYVVPPFLVGYLAYDMLTKKHQQLMRKNPADFENDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-09-13" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AT73</accession>
    <name>A0A5N4AT73_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HECT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_06312</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000004">
        <property type="protein sequence ID" value="KAB0800572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AT73"/>
    <dbReference type="InParanoid" id="A0A5N4AT73"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0800572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="585" mass="67618" checksum="C6364CC53D6B5F74" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AUF9</accession>
    <name>A0A5N4AUF9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">One cut domain family member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PPYR_05303</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the CUT homeobox family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000003">
        <property type="protein sequence ID" value="KAB0800949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AUF9"/>
    <dbReference type="FunCoup" id="A0A5N4AUF9">
        <property type="interactions" value="44"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AUF9"/>
    <dbReference type="OrthoDB" id="10068888at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000054">
        <property type="entry name" value="One cut domain family member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.40:FF:000005">
        <property type="entry name" value="One cut domain family member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003350">
        <property type="entry name" value="CUT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051649">
        <property type="entry name" value="CUT_Homeobox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14057:SF47">
        <property type="entry name" value="HOMEOBOX PROTEIN ONECUT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14057">
        <property type="entry name" value="TRANSCRIPTION FACTOR ONECUT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02376">
        <property type="entry name" value="CUT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01109">
        <property type="entry name" value="CUT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51042">
        <property type="entry name" value="CUT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 8 9" id="KW-0371">Homeobox</keyword>
    <keyword evidence="7 8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CUT" evidence="13">
        <location>
            <begin position="347"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="12">
        <location>
            <begin position="455"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="8">
        <location>
            <begin position="457"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="191"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="298"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="435"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="513"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="205"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="220"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="308"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="513"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="536"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAB0800949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="558" mass="61387" checksum="57D1F38116A1F34C" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AVZ1</accession>
    <name>A0A5N4AVZ1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_05752</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000003">
        <property type="protein sequence ID" value="KAB0801398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AVZ1"/>
    <dbReference type="InParanoid" id="A0A5N4AVZ1"/>
    <dbReference type="OrthoDB" id="6157510at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040350">
        <property type="entry name" value="TMEM272"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33444:SF2">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33444">
        <property type="entry name" value="SI:DKEY-19B23.12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0801398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="171" mass="19445" checksum="DDA1ADD0B2A67348" modified="2020-02-26" version="1">MEVERTITSRKSELSIQGIKEHITERANHPTASGTLVLFLILNAVMLIVGSIKKDDCPAEPFIPIYLIVAGAVGVVSKLLPFANRKLDLKCLTLVIYILYIFEFVWMVFGSYWVFSNYKPIFDDSGDRSWYCNRTAYYLAFGLLTVNWILLGITVMLICCAFVVSIFLRDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AX12</accession>
    <name>A0A5N4AX12_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PPYR_04042</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0801856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AX12"/>
    <dbReference type="InParanoid" id="A0A5N4AX12"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11781">
        <property type="entry name" value="SH3_Sorbs_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11782">
        <property type="entry name" value="SH3_Sorbs_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11780">
        <property type="entry name" value="SH3_Sorbs_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000001">
        <property type="entry name" value="Sorbin and SH3 domain-containing protein 1 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050384">
        <property type="entry name" value="Endophilin_SH3RF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14167:SF116">
        <property type="entry name" value="CAP, ISOFORM AC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14167">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00499">
        <property type="entry name" value="P67PHOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="132"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="201"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="348"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0801856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="407" mass="46705" checksum="AA6A6966E660DE76" modified="2020-02-26" version="1">MYNIKEEIQNEGTKLPQDYKNDVKRAKSPRRYVENDVTIHYKTPVRQEVKEPISEEELSRRQAEHMKRVYEEERRRKYLQVSDFDDELQDMNNRRHTDNFIPSQKSPIPLNRYDDFLAEDSPKIKPRPRSPEHRLVARALYNFVGQSAREITFRKGDIIYIRRQVDKNWYEGEHNAMVGLFPANYVEIIPFDGVKSTPRRNHEGQARAKFNFIAQTHLELSLAKGELVVITRRVDDNWFEGRIGGRKGIFPVSYVEVLIDAASPPPPTPLSSKPVASPAAHSLLLNGSAGGKESMGSHKYTPSMPYQQHFTSSYRAKPLQIASTSYGSSSKSSGKNPINEVLHIDTHSEPVPYRALYKYRPQNDDELELLEGDVVFVLEKCDDGWYVGSSQRTGAFGTFPGNYVERI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AXM4</accession>
    <name>A0A5N4AXM4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Coiled-coil domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_04287</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AXM4"/>
    <dbReference type="InParanoid" id="A0A5N4AXM4"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045323">
        <property type="entry name" value="CCDC34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025259">
        <property type="entry name" value="CCDC34/181"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23247:SF2">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23247">
        <property type="entry name" value="NY-REN-41 ANTIGEN L15 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13904">
        <property type="entry name" value="CCDC34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Coiled-coil" evidence="2">
        <location>
            <begin position="85"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0802101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="247" mass="28804" checksum="A1AB10F7DA77A775" modified="2020-02-26" version="1">MSTESIANVRTFMNGAVSIESTTTLTANEKPRKRISCSYSNAQLCENADASSFSSESSLLDERPSTTPSKSLASTPNLLNGMGLEQLKSLKAKRAEEKKREENRIRLEKQRQNFKRWLANKKDEEEKERISKEKMTKHQSEKDYEKQRRQKEAELKYKLWCKRKEQEELEKKLKAKIDEIKSSEDHDRRTERNQTAYQNWLKNSVYKPMPIPLNRGLETLRSSASVTYINPIPWQPNIDESCLNSQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AXU6</accession>
    <name>A0A5N4AXU6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Acyl-CoA synthetase short-chain family member 3, mitochondrial</fullName>
            <ecNumber evidence="4">6.2.1.1</ecNumber>
            <ecNumber evidence="3">6.2.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Acetate--CoA ligase 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Propionate--CoA ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PPYR_04254</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetate + ATP + CoA = acetyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23176"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:23177"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>butanoate + ATP + CoA = butanoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:46172"/>
            <dbReference type="ChEBI" id="CHEBI:17968"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57371"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:46173"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>propanoate + ATP + CoA = propanoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20373"/>
            <dbReference type="ChEBI" id="CHEBI:17272"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57392"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.17"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:20374"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.1" evidence="4"/>
    <dbReference type="EC" id="6.2.1.17" evidence="3"/>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AXU6"/>
    <dbReference type="FunCoup" id="A0A5N4AXU6">
        <property type="interactions" value="85"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AXU6"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003987">
        <property type="term" value="F:acetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050218">
        <property type="term" value="F:propionate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000011">
        <property type="entry name" value="Acetyl-coenzyme A synthetase 2-like, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43347">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43347:SF3">
        <property type="entry name" value="ACYL-COA SYNTHETASE SHORT-CHAIN FAMILY MEMBER 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acetyl-coenzyme A synthetase N-terminal" evidence="12">
        <location>
            <begin position="44"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="10">
        <location>
            <begin position="107"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="11">
        <location>
            <begin position="556"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00042755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAB0802068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="653" mass="72986" checksum="37D611F4BBDC80D1" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AY06</accession>
    <name>A0A5N4AY06_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Acyl-CoA synthetase short-chain family member 3, mitochondrial</fullName>
            <ecNumber evidence="2">6.2.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Acetate--CoA ligase 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_04428</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>butanoate + ATP + CoA = butanoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:46172"/>
            <dbReference type="ChEBI" id="CHEBI:17968"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57371"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:46173"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.1" evidence="2"/>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AY06"/>
    <dbReference type="FunCoup" id="A0A5N4AY06">
        <property type="interactions" value="85"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AY06"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003987">
        <property type="term" value="F:acetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050218">
        <property type="term" value="F:propionate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43347">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43347:SF3">
        <property type="entry name" value="ACYL-COA SYNTHETASE SHORT-CHAIN FAMILY MEMBER 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acetyl-coenzyme A synthetase N-terminal" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="6">
        <location>
            <begin position="32"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="7">
        <location>
            <begin position="477"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00040004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00042755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0802242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="602" mass="66522" checksum="AD28D672668C19F9" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AYK5</accession>
    <name>A0A5N4AYK5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">YqaJ viral recombinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_04549</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AYK5"/>
    <dbReference type="InParanoid" id="A0A5N4AYK5"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd22343">
        <property type="entry name" value="PDDEXK_lambda_exonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019080">
        <property type="entry name" value="YqaJ_viral_recombinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47526">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09588">
        <property type="entry name" value="YqaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YqaJ viral recombinase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0802363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="151" mass="17665" checksum="8C1F9527246797AE" modified="2020-02-26" version="1">MYGCRHEATALNRFYEIHTAIHTCKVSSCGLFINRKFPWCAATPDALLHCQICARDSSVFEITKEGKGCLLKTPTGMMLNRKHAYFYQVQMQMAVTNCTSCFFVVWSKDIYIEKIGFMDEFWTEEKKRAEMFFQKVIIPELLGRYYTAHQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AZ61</accession>
    <name>A0A5N4AZ61_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Guanine nucleotide-binding protein subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PPYR_04759</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the G-alpha family. G(q) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AZ61"/>
    <dbReference type="InParanoid" id="A0A5N4AZ61"/>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007188">
        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003977">
        <property type="entry name" value="Guanine nucleotide-binding protein G(q) subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000654">
        <property type="entry name" value="Gprotein_alpha_Q"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF329">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN G(Q) SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00442">
        <property type="entry name" value="GPROTEINAQ"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4 10 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 9 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0807">Transducer</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="62"/>
            <end position="68"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="87"/>
            <end position="91"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="156"/>
            <end position="159"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU369122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAB0802573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="241" mass="28349" checksum="1D1A39E6A2C108D8" modified="2020-02-26" version="1">MEIDRVAAPDYLPTEQDILRVRVPTTGIIEYPFDLDEIRFSYLSDLERIGDPEYLPTEQDILRARAPTTGILEYPFDLDSIIFRMVDVGGQRSERRKWIHCFENVTSIIFLVALSEYDQILFESENENRMEESKALFKTIITYPWFQHSSVILFLNKKDLLEEKIMYSHLVDYFPEYDGPQRDAIAAREFILRMFVDLNPDSEKIIYSHFTCATDTENIKFVFAAVKDTILQSNLREYNLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AZP1</accession>
    <name>A0A5N4AZP1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed DNA polymerase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_04990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AZP1"/>
    <dbReference type="InParanoid" id="A0A5N4AZP1"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511">
        <property type="entry name" value="PROTEIN CBG23764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511:SF12">
        <property type="entry name" value="RHO TERMINATION FACTOR N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="His-Me finger endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0802804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="729" mass="84734" checksum="3F0012BDC4697394" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B083</accession>
    <name>A0A5N4B083_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_05207</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0803021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B083"/>
    <dbReference type="InParanoid" id="A0A5N4B083"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098592">
        <property type="term" value="C:cytoplasmic side of apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035332">
        <property type="term" value="P:positive regulation of hippo signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00136">
        <property type="entry name" value="PDZ_canonical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018980">
        <property type="entry name" value="FERM_PH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047145">
        <property type="entry name" value="FRMD6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13429:SF12">
        <property type="entry name" value="FERM AND PDZ DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13429">
        <property type="entry name" value="FERM DOMAIN (PROTEIN4.1-EZRIN-RADIXIN-MOESIN) FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09380">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00935">
        <property type="entry name" value="BAND41"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01196">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FERM" evidence="1">
        <location>
            <begin position="285"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="830"/>
            <end position="911"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0803021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1113" mass="125979" checksum="5A419570DF46E8EC" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B1N7</accession>
    <name>A0A5N4B1N7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed DNA polymerase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_00475</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B1N7"/>
    <dbReference type="InParanoid" id="A0A5N4B1N7"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05481">
        <property type="entry name" value="retropepsin_like_LTR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1800.10">
        <property type="entry name" value="His-Me finger endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004211">
        <property type="entry name" value="Endonuclease_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038563">
        <property type="entry name" value="Endonuclease_7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511">
        <property type="entry name" value="PROTEIN CBG23764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511:SF12">
        <property type="entry name" value="RHO TERMINATION FACTOR N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02945">
        <property type="entry name" value="Endonuclease_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="His-Me finger endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0803505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1031" mass="119219" checksum="B55BCBECC5F106B3" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B1V3</accession>
    <name>A0A5N4B1V3_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_00547</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B1V3"/>
    <dbReference type="InParanoid" id="A0A5N4B1V3"/>
    <dbReference type="OrthoDB" id="2148342at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034237">
        <property type="term" value="F:protein kinase A regulatory subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053084">
        <property type="entry name" value="AKAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025663">
        <property type="entry name" value="AKAP_28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35075">
        <property type="entry name" value="A-KINASE ANCHOR PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35075:SF1">
        <property type="entry name" value="A-KINASE ANCHOR PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14469">
        <property type="entry name" value="AKAP28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0803577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="282" mass="31880" checksum="AEE5168832F1E78D" modified="2020-02-26" version="1">MSFQTDPDASEGDKEVYVETLQDNEPHSSESSLGSGIPPAPPCTPIELSECTEVDTNELLPNTLTEQTSDIVIDEIERRIRISEAAREISCSYISEALTDECILYSDIETFSGYFVDEIIETSIGRLIQEQDKLGITVIIEAARSTSHTNSALDSLWPRNGEFTKETGMDAIHEYLRTWIYVEDWLYCVDFLMVQSDECSEYYLYEAKFSIPTRCYPIPQATASVFFTVEVSRIKPLYCPVDISYVFEGSSLVRVPGKVPFDESFLFDIVDAKLSLYKSISF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B2V5</accession>
    <name>A0A5N4B2V5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ER membrane protein complex subunit 7 beta-sandwich domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PPYR_00875</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMC7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B2V5"/>
    <dbReference type="FunCoup" id="A0A5N4B2V5">
        <property type="interactions" value="1811"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4B2V5"/>
    <dbReference type="OrthoDB" id="27095at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019008">
        <property type="entry name" value="Beta_sandwich_EMC7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039163">
        <property type="entry name" value="EMC7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13605">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13605:SF4">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09430">
        <property type="entry name" value="EMC7_beta-sandw"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="Starch-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024356341" description="ER membrane protein complex subunit 7 beta-sandwich domain-containing protein" evidence="8">
        <location>
            <begin position="26"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="ER membrane protein complex subunit 7 beta-sandwich" evidence="9">
        <location>
            <begin position="54"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0803905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="228" mass="26386" checksum="43757B79598EBAA5" modified="2020-02-26" version="1">MTIAMNKYFLILSVVFVSYLKAVSSESNLEDDNETQGRYLIEGKVFPMELPFTPPNWQANTRLHVNGGEYIGFVKEDGTFIIHNMPSGSYILEVLHPEFSYEPVRVEINSKGKFRARKVNHIQTSVVVQVPYPLKLKPLGKTRYFQVREQWRITDFLFNPMILMMFLPLLLIMILPKMLSDPETKREMEQIGSLTNFEMPAVSDYVTNYLATAQSQPVKKNAKNKKRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B307</accession>
    <name>A0A5N4B307_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_00878</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B307"/>
    <dbReference type="InParanoid" id="A0A5N4B307"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007409">
        <property type="term" value="P:axonogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048665">
        <property type="term" value="P:neuron fate specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047169">
        <property type="entry name" value="ISL1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24204">
        <property type="entry name" value="INSULIN GENE ENHANCER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24204:SF8">
        <property type="entry name" value="TAILUP, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="43"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0803908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="112" mass="11986" checksum="8886883C249B5F38" modified="2020-02-26" version="1">MQGIPMVASSPVRHDSPIGVHPLEVQAYQPPWKALSDFALHSDLEQPPHAPGFQQLVNQMHGYDLPPPSMGPTPPGPPMPLSAPPSDGMTHPDSTDSYVTYLESDDSLPASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B397</accession>
    <name>A0A5N4B397_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HTH psq-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_01061</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B397"/>
    <dbReference type="InParanoid" id="A0A5N4B397"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15489">
        <property type="entry name" value="PHD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF71">
        <property type="entry name" value="ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
        <property type="entry name" value="HTH_psq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH psq-type" evidence="4">
        <location>
            <begin position="17"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="DDE-1" evidence="3">
        <location>
            <begin position="199"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="404"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="412"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="428"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0804091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="524" mass="59608" checksum="F47A1D2BD8B046CD" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B559</accession>
    <name>A0A5N4B559_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_01470</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B559"/>
    <dbReference type="InParanoid" id="A0A5N4B559"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018289">
        <property type="entry name" value="MULE_transposase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052797">
        <property type="entry name" value="RegFact_GeneExpr_CellDeath"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33936:SF24">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33936">
        <property type="entry name" value="PROTEIN CBG17840"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10551">
        <property type="entry name" value="MULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="3"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="43"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="81"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="656"/>
            <end position="683"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0804500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="766" mass="89147" checksum="5A69C838BE4AFE6A" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B617</accession>
    <name>A0A5N4B617_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_02015</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0805045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B617"/>
    <dbReference type="FunCoup" id="A0A5N4B617">
        <property type="interactions" value="25"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4B617"/>
    <dbReference type="OrthoDB" id="6601693at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007608">
        <property type="term" value="P:sensory perception of smell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23992">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.20">
        <property type="entry name" value="Pheromone/general odorant binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006170">
        <property type="entry name" value="PBP/GOBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036728">
        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11857">
        <property type="entry name" value="ODORANT BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01395">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024386316" evidence="2">
        <location>
            <begin position="19"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0805045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="143" mass="15427" checksum="0250ED28C911522B" modified="2020-02-26" version="1">MLLTVLCLTLLAATATSAEISQDIITNIRNTIKDIKGPCLQSEGASETDLEDILSKGIYSTSRNLKCALKCLYIGTNIISSTGVINEANMKLKTGTINVNTQNAVFANCAGFTNADLCERVYEISKCTYRTLKGSFGATWLDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B680</accession>
    <name>A0A5N4B680_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PPYR_02023</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0805053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B680"/>
    <dbReference type="FunCoup" id="A0A5N4B680">
        <property type="interactions" value="75"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4B680"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000068">
        <property type="entry name" value="transmembrane protease serine 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050127">
        <property type="entry name" value="Serine_Proteases_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24264:SF20">
        <property type="entry name" value="TRYPSIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24264">
        <property type="entry name" value="TRYPSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024309876" description="Peptidase S1 domain-containing protein" evidence="6">
        <location>
            <begin position="18"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="7">
        <location>
            <begin position="28"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0805053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="468" mass="51147" checksum="5B1C69207D153BBE" modified="2020-02-26" version="1">MKTFITFSILLLAFAQAKFIHFDPPTKIVGGDEAALHGFPYQVAIFIQVPQGTGFCGGSLISDKHILTAAHCVSSASSALVMVGAHNIKAEESNRQEFNTTSFAVHEQWFPLFILNDIAIIKINDAIQVDGVTVKILALAPATEDAVLTGLQATVSGWGKDSDAAQGVSSVLRYVNSTIIENSICKIFYFGNIRDEHICMNGWEGKSSCQGDSGGPLVMTRDGELTQYGVVSFGIIFGCEKGWPSAAIFILDVDDEDLFCGGSLCSRYHVLTAAHCLYNARESLILLGAHNITVNEPNVQHFVSSRFFVHPRYSSSTIHNDIAVIMLPKPAVINEFVQIISLHQNQTLLFGQEGTVSGWGLQSTKARDISPVLRHVSLRIVFHFICSATYKDFTSGTQICQHEAKGKSTCSGDSGGPVVVYDRKKRRRIQVGVVSFGHRDGCEVGKPVVQTRVSAYYSWIESIIKNDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B6G0</accession>
    <name>A0A5N4B6G0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PPYR_02167</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0805197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B6G0"/>
    <dbReference type="InParanoid" id="A0A5N4B6G0"/>
    <dbReference type="OrthoDB" id="7312725at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026516">
        <property type="entry name" value="THAP1/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46600">
        <property type="entry name" value="THAP DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46600:SF11">
        <property type="entry name" value="THAP DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00692">
        <property type="entry name" value="DM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="7">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="339"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0805197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="406" mass="46357" checksum="4C5664B592F0E230" modified="2020-02-26" version="1">MTKPCIVPKCKTGYKSVKQKTSVFKVPKDSEMRKKWMLAIPKICVNDVFYVCELHFEKKFLKKQCVMYNEKGDVIFKRDYERPQLQPGAYPTIFNNVSETVNDCSMDDVPCAERSYATNDLISEALQLPKDQERDQEHVHNVDQDRTLVDNCSDLNMEVDIEHPSVNEDQGCEPQMLTAADMETQPETKILRIIDKISVGYSSEVSAVSIPWSWTASEAIIDNKHHMIFSHVISRRSAIPTLTKAVTIDKTGKIKYSVHGRKLEPNEGSGFPLQLENCEDVPAILLQFEKRRACKGVILSGNVNVQLSAIFESSDGVWHSKDCTLITKGRKCVACKDLLQRINRSKRRAINKLKVLRAKQLHDEKQRKLCVAKKAESLKKKLEKKCDELRTLVKTKIKECRNVSQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-06-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B6X3</accession>
    <name>A0A5N4B6X3_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_02319</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0805349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B6X3"/>
    <dbReference type="InParanoid" id="A0A5N4B6X3"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0805349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="177" mass="20144" checksum="12BA6AE3548DA624" modified="2020-02-26" version="1">MADHNVTSEWWGGPYSYCVLIVHFITDNNQHLMTTAMDIDLDELNNTTYRKPLKNARFTCGSSILDKVWRSGNLQPPILHPGGLCPPPPPGGPSPTVTSSTFAYSSIDTFSRFTQISSLTKKKLNLELSCRPNTSTECGLMHANFYVYQHLHLDFNSIPYLYTGNYVLRFIKFRYVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-06-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B757</accession>
    <name>A0A5N4B757_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_02409</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0805439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="InParanoid" id="A0A5N4B757"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0805439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="131" mass="14679" checksum="4A8898A0B47A961E" modified="2020-02-26" version="1">MQIVQHAVKIATMKKDLCSKRFIDQDLRANNEGAENEVKEMITFEELKEHLQDEPSYMTLSQMLIEEEQKNILEEACNVIIKVSSAPSFIPTTSTSSTIANSVSEDIAVAGYMDCQLKSDLGKFFGEAQLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1JZW2</accession>
    <name>A0A1Y1JZW2_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_09302</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
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            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01099340">
        <property type="protein sequence ID" value="JAV53370.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1JZW2"/>
    <dbReference type="OrthoDB" id="6761993at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="745"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="952"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1001"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1034"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1078"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1155"/>
            <end position="1292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1357"/>
            <end position="1399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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</entry>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
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                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
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                <person name="Fallon T.R."/>
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</entry>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
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        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
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                <person name="Bessho-Uehara M."/>
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                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
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                <person name="Shigenobu S."/>
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                <person name="Weng J.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </reference>
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    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="5 6" id="KW-0505">Motor protein</keyword>
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            <end position="342"/>
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        <source>
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        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="JAV55339.1"/>
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        <source>
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        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
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    <sequence length="628" mass="71490" checksum="6CA8AA9080A23E65" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1K862</accession>
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        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
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        <name evidence="14" type="ORF">PPYR_14615</name>
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        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
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            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
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    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
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                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="14">1611_PpyrPB1</strain>
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    <reference evidence="14" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
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        </source>
    </reference>
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        <reaction evidence="6">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
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            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
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            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
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        </reaction>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="95"/>
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            <begin position="126"/>
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        </location>
    </feature>
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            <begin position="333"/>
            <end position="483"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
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    </feature>
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            <begin position="95"/>
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        </location>
    </feature>
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            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
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            <end position="41"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAB0792656.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1KBF0</accession>
    <name>A0A1Y1KBF0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_11268</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
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        <name type="scientific">Photinus pyralis</name>
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    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
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                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
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                <person name="Sander Lower S.E."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </location>
    </feature>
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        </location>
    </feature>
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        <source>
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            <dbReference type="EMBL" id="JAV59018.1"/>
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            <dbReference type="EMBL" id="KAB0797211.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="859" mass="94596" checksum="C62996845CF4C655" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
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        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
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                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
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                <person name="Silva C.J."/>
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                <person name="Hall D.W."/>
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                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
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        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
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                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
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        </source>
    </reference>
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    <comment type="subcellular location">
        <subcellularLocation>
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    <feature type="domain" description="PHD-type" evidence="10">
        <location>
            <begin position="282"/>
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        </location>
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        <location>
            <begin position="1"/>
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            <begin position="12"/>
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        <source>
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        <source>
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    </evidence>
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        <source>
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            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="JAV58617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAB0800157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="350" mass="36915" checksum="077050A82D24FB14" modified="2017-08-30" version="1">MSHLSPFRLNVPNLSTDLSSSASNPKKRRKNVQTPIQQSPNVQDLLPPPLSGYGDTIVASNPFDDCPSSVSSLNSVRVGPGMGMPPNMGIAMHSMNMCRPMGSQMPMGGPPMIHSPNAHQNPQMMNSPMMMTGPRVNGPMGAQMGSHMMSTANGSSIHAIAGPMHSPMGPGMTGPMSGVGNGPMNAPLSSPMGGPGPISGPMTNGPMNGPMNGMNPQMNGPLPSNMGVNTPNGSIGPPLNNNFMMTPMNSMYSKPMPVSAGKVYPADQPMVFNSQNPNAPPIYPCGVCHKEVHDNDQAILCESGCNFWFHRGCTGLTEAAFQLLTAEVYAEWVCDKCLASKNIPLVKFKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1KJI0</accession>
    <name>A0A1Y1KJI0_PHOPY</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="4" type="ORF">PPYR_00374</name>
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    <organism evidence="3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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            <begin position="1"/>
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        </location>
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        <location>
            <begin position="46"/>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="JAV61474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0803404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="209" mass="24058" checksum="0C20186E84EA695D" modified="2017-08-30" version="1">MHSVKLFFLLLSAEVFSKGRSTKENGNNTEPIDALKAALIAHKKECASSNDPPPIDRKVEVKNTKNSGSKEYPTHPRVESGRHPYRDYNYEHDYVGQRGGYELDPYPTRVGYNPGYIRLKRNNDEADYDDDQCLIQCLFEYLEVLDENQSPSEFALIKWFQENTPQNEKRIKAIREIRRCFGHTAATDDGDGCDYSKSLLKCLNLEIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1KM74</accession>
    <name>A0A1Y1KM74_PHOPY</name>
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        <recommendedName>
            <fullName evidence="9">LRRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="7" type="ORF">PPYR_05000</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
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            <taxon>Pterygota</taxon>
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            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
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            <taxon>Elateroidea</taxon>
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            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01079177">
        <property type="protein sequence ID" value="JAV62502.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1KM74"/>
    <dbReference type="FunCoup" id="A0A1Y1KM74">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1KM74"/>
    <dbReference type="OrthoDB" id="1687175at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001164">
        <property type="entry name" value="GH01279p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050328">
        <property type="entry name" value="Dev_Immune_Receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373:SF370">
        <property type="entry name" value="FISH-LIPS, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373">
        <property type="entry name" value="SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036029780" description="LRRCT domain-containing protein" evidence="5">
        <location>
            <begin position="25"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="415"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="JAV62502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0802814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="471" mass="53863" checksum="218A9774B41AD6E0" modified="2017-08-30" version="1">MSTISVRILIFALFLSEQFQLFSSEELCSFSKSKLKCMCRYQAQPNTPFPVHSADCTRMSLTEFPKDTHLPSVEDLDLSRNLISTLDHDHNNFESVLLRFLNLSFNKIAYLFQDFFINTPNLSVLDLSHNEIVYLSNANVFRGLGNLTVLKLSFNKLSTLPEDVFRPLKNLEELDLRFNYLGVTLMQHSSFFQLSMGFPRNISKLNLDGVGISKLPNGYFDEGSHLKYLSLSDNPLTEIPLVSSIVEHLDLSGTHITTVSGKHLPYQSLKVLKLNRLKRLEEIEHYAFLNLKSLEELHLSDSKRLRSLPNLAFGILSNDTEVTLKRMHISRTGIRTLNSTYLHLFKKVKFVDLQHNPWDCKCEILWLQQLNGSLHRYDNIRCLTPRNLRTKKIMSLSDKDMPDCFNSYANVQKTLIGIFSILVALLCLLILYLLYLGPFHPPKTRGVGPGSPYQSISLEIDPCKAEDASRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1KTB2</accession>
    <name>A0A1Y1KTB2_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mediator of RNA polymerase II transcription subunit 28</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Mediator complex subunit 28</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PPYR_10813</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 28 family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01076733">
        <property type="protein sequence ID" value="JAV63691.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1KTB2"/>
    <dbReference type="FunCoup" id="A0A1Y1KTB2">
        <property type="interactions" value="1867"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1KTB2"/>
    <dbReference type="OrthoDB" id="2286203at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021640">
        <property type="entry name" value="Mediator_Med28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13512">
        <property type="entry name" value="MEDIATOR COMPLEX SUBUNIT 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13512:SF2">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11594">
        <property type="entry name" value="Med28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="5 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="133"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="175"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="JAV63691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAB0796752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="273" mass="30324" checksum="BDEFDC34486A2005" modified="2017-08-30" version="1">MKEPSASPPVSAMATPTNGSGNLVDEFEEAFQHCLNVLTKEEAVGSTDKDDIRTEVEQTTLRFIDLARQMEAFFLQKRFLLSALKPEMVVKEDINELRLELTRKDELLKRHYEKIAVWQNLLADLQGYAKSPAQSSSTQNLISNGSSVPPSPIPNIPGNQTPNQMIVSAMSPTMQQMQQQQLQQMQQQQQQLQLQQQQQMQQLQQQMQVPPGMSSSGVGVGPGMMSPQQAMFMQQQGMGGARTSFPQQGGLLQGPLAYLEKTTSNIGMTDGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1KTC5</accession>
    <name>A0A1Y1KTC5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PPYR_00319</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="19 20" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">1611_PpyrPB1</strain>
            <tissue evidence="19">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">1611_PpyrPB1</strain>
            <tissue evidence="19">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the calcineurin regulatory subunit family. CHP subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01074177">
        <property type="protein sequence ID" value="JAV64649.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1KTC5"/>
    <dbReference type="FunCoup" id="A0A1Y1KTC5">
        <property type="interactions" value="296"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1KTC5"/>
    <dbReference type="OrthoDB" id="191686at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051875">
        <property type="entry name" value="Calcineurin_B_homologous"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46002">
        <property type="entry name" value="EG:114D9.1 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0519">Myristate</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="EF-hand" evidence="17">
        <location>
            <begin position="105"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="17">
        <location>
            <begin position="146"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00038164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="JAV64649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAB0803349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="190" mass="22183" checksum="C0BB1134FA67B43E" modified="2017-08-30" version="1">MGNRSSLLLREEEIAQIQQETGFTPNQIERLYSRFTSLDRGDCGTLSRDDFLRIPELAINPLGERIVNSFFQGDMYNDRVNFRQFMNVLAHFRPVKKNKDNRLNSREAKLKFAFKMYDLDNDDLISRDELLAILHMMVGANISEEQLTSIAERTILEADEDGDQMISFEEFCKALQRTDVEQKMSIRFLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1KTI5</accession>
    <name>A0A1Y1KTI5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Nucleoporin Nup133/Nup155-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PPYR_01140</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus envelope</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleoporin Nup133 family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01078419">
        <property type="protein sequence ID" value="JAV62726.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1KTI5"/>
    <dbReference type="FunCoup" id="A0A1Y1KTI5">
        <property type="interactions" value="2240"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1KTI5"/>
    <dbReference type="OrthoDB" id="103454at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000972">
        <property type="term" value="P:transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007187">
        <property type="entry name" value="Nucleoporin_Nup133/Nup155_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014908">
        <property type="entry name" value="Nucleoporin_Nup133/Nup155_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037624">
        <property type="entry name" value="Nup133-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13405">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13405:SF11">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03177">
        <property type="entry name" value="Nucleoporin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08801">
        <property type="entry name" value="Nucleoporin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117289">
        <property type="entry name" value="Nucleoporin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup133/Nup155-like N-terminal" evidence="9">
        <location>
            <begin position="65"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin Nup133/Nup155-like C-terminal" evidence="8">
        <location>
            <begin position="812"/>
            <end position="996"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="JAV62726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0804170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1129" mass="127280" checksum="467D6B067D00AC83" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1KX83</accession>
    <name>A0A1Y1KX83_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_09156</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01076999">
        <property type="protein sequence ID" value="JAV63477.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1KX83"/>
    <dbReference type="InParanoid" id="A0A1Y1KX83"/>
    <dbReference type="OrthoDB" id="8196563at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00821">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000280">
        <property type="entry name" value="Uncharacterized protein, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037370">
        <property type="entry name" value="Pleckstrin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12092:SF16">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12092">
        <property type="entry name" value="PLECKSTRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="66"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="JAV63477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0798163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="337" mass="39313" checksum="A68D8CE853486BE8" modified="2017-08-30" version="1">MLLKMDNGTTGRASAVPGILDSPTLARVERAMLRHEEGVQRETAILQRQAFTQSLLPSNYGKDAVHAIKKGLLWQQRDKLFSRWKERYFILTRDYLHCFRRASGSDRISEMGQFLFKIKLVDVDRVEWENKKTYSTVVLILGRDGKIFLRAPEGLEDWFELLEECTLTSKERRKALRTSHDGKSKDNNNVLNSLDEWLMARQKIPKGRLPTDSISTRQDSVRRRDWTPRDEDWENPTLDNRLSLLTDIDINSYNDDTLDAPSVASYRMNEDVLCIQPPSLRPSGSFRSSRNTTGAIKRPPTNTSEIHSQLMKFRERSYSDIQRVDRRLWRPHVDRFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1KY10</accession>
    <name>A0A1Y1KY10_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_07053</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01070861">
        <property type="protein sequence ID" value="JAV66254.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1KY10"/>
    <dbReference type="FunCoup" id="A0A1Y1KY10">
        <property type="interactions" value="1003"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1KY10"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000006">
        <property type="entry name" value="Aldo-keto reductase family 1 member A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="7">
        <location>
            <begin position="18"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="6">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="JAV66254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0799173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="314" mass="35577" checksum="5DF599EF7A60C7C5" modified="2017-08-30" version="1">MAAVPTVKLNNGVQIPILGLGTWQSPESEVKQAVMDAIDIGYRHFDCAHIYENQKAIGEAISAKISQGVVKRSDLFITSKLWNTFHRPGSVEPILRSTLKEMNLEYFDLYLIHWPFGFKEGDTLYPAGPDGFEYSDYDYTETWAAMEEVHKKGLARAIGVSNFNKHQIERVLAVCTITPAMNQVECHPYFNQKKLKEFCESKTITITAYSPLGSPGIQTDGKRKSLLNDPVLKDIGTKYHKTAAQIAIRYQMERGIVVIPKSVHKKRLIENFSVLDFSLSSEDIAKIDALGTDQRVVTFDEVRSHRFYPFSDDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1L1J4</accession>
    <name>A0A1Y1L1J4_PHOPY</name>
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        <recommendedName>
            <fullName evidence="3">Nucleoporin NUP35</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">35 kDa nucleoporin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Nucleoporin NUP53</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PPYR_09575</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">1611_PpyrPB1</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">1611_PpyrPB1</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Nup35 family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01069078">
        <property type="protein sequence ID" value="JAV66658.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="FunCoup" id="A0A1Y1L1J4">
        <property type="interactions" value="1597"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1L1J4"/>
    <dbReference type="OrthoDB" id="3365060at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044613">
        <property type="term" value="C:nuclear pore central transport channel"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:nuclear pore nuclear basket"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006607">
        <property type="term" value="P:NLS-bearing protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006999">
        <property type="term" value="P:nuclear pore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12441">
        <property type="entry name" value="RRM_Nup53_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000095">
        <property type="entry name" value="Putative Nucleoporin NUP53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017389">
        <property type="entry name" value="Nucleoporin_NUP53"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007846">
        <property type="entry name" value="RRM_NUP35_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21527">
        <property type="entry name" value="NUCLEOPORIN NUP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21527:SF6">
        <property type="entry name" value="NUCLEOPORIN NUP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05172">
        <property type="entry name" value="RRM_Nup35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038119">
        <property type="entry name" value="Nucleoporin_NUP53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51472">
        <property type="entry name" value="RRM_NUP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="8 12" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="9 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RRM Nup35-type" evidence="14">
        <location>
            <begin position="140"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="JAV66658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAB0798582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="273" mass="29838" checksum="137AFD5DBB3A2E88" modified="2017-08-30" version="1">MEPMTLGSAPGSPSSPSANPNYLPAFLMGNAKPASPNSPELRKNISFNLTPSDRSSMRQKLFSPSVPDVPKHLPLSVESNTTPGPPKQSLFDTLDVRRSINTNTPKSITHTQNSFQHDSFSHSFNETSVERADLMRQATACSNLWVTVFGFPTTASGSIFTQFASCGMITDKRFPAQGNWMHLKFSNTLEVSKALSLNGKLISNSIMIGVVPYQNNTVRESGESPMPKTPTRARSLRLSFVSPQNSNMVITPENVPQKSTGILTKAMDYVLGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1L3E4</accession>
    <name>A0A1Y1L3E4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA (cytosine(34)-C(5))-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.203</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PPYR_00369</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.203" evidence="2"/>
    <dbReference type="EMBL" id="GEZM01066093">
        <property type="protein sequence ID" value="JAV68192.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1L3E4"/>
    <dbReference type="FunCoup" id="A0A1Y1L3E4">
        <property type="interactions" value="2398"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1L3E4"/>
    <dbReference type="OrthoDB" id="6093671at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016428">
        <property type="term" value="F:tRNA (cytidine-5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049560">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057285">
        <property type="entry name" value="Pre-PUA_NSUN2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057286">
        <property type="entry name" value="PUA_NSUN2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023270">
        <property type="entry name" value="RCMT_NCL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22808">
        <property type="entry name" value="NCL1 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22808:SF1">
        <property type="entry name" value="RNA CYTOSINE-C(5)-METHYLTRANSFERASE NSUN2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25376">
        <property type="entry name" value="Pre-PUA_NSUN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25378">
        <property type="entry name" value="PUA_NSUN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02011">
        <property type="entry name" value="RCMTNCL1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="3" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="12">
        <location>
            <begin position="53"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="425"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="668"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="433"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="676"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="310"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="172"/>
            <end position="178"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="JAV68192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAB0803399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="690" mass="78701" checksum="A8F1A5464830E434" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LB20</accession>
    <name>A0A1Y1LB20_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Tryptophan--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="3">6.1.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">(Mt)TrpRS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Tryptophanyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PPYR_09683</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">1611_PpyrPB1</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">1611_PpyrPB1</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the attachment of tryptophan to tRNA(Trp) in a two-step reaction: tryptophan is first activated by ATP to form Trp-AMP and then transferred to the acceptor end of tRNA(Trp).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>tRNA(Trp) + L-tryptophan + ATP = L-tryptophyl-tRNA(Trp) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24080"/>
            <dbReference type="Rhea" id="RHEA-COMP:9671"/>
            <dbReference type="Rhea" id="RHEA-COMP:9705"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78535"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="3"/>
    <dbReference type="EMBL" id="GEZM01060842">
        <property type="protein sequence ID" value="JAV70859.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1LB20"/>
    <dbReference type="InParanoid" id="A0A1Y1LB20"/>
    <dbReference type="OrthoDB" id="15808at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070183">
        <property type="term" value="P:mitochondrial tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00806">
        <property type="entry name" value="TrpRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000082">
        <property type="entry name" value="MSW1p Mitochondrial tryptophanyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.240.10:FF:000002">
        <property type="entry name" value="Tryptophan--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00140_B">
        <property type="entry name" value="Trp_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024109">
        <property type="entry name" value="Trp-tRNA-ligase_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050203">
        <property type="entry name" value="Trp-tRNA_synthetase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00233">
        <property type="entry name" value="trpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43766">
        <property type="entry name" value="TRYPTOPHAN--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43766:SF1">
        <property type="entry name" value="TRYPTOPHAN--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 14" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00059972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00069760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00080951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="JAV70859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAB0798690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="376" mass="42388" checksum="BBBA950EA1AE2D32" modified="2017-08-30" version="1">MFFINRLPIVLTRKLKSIRMMSTKLKKSDPSFPTKYFSGIQPTGDIHLGNYLGAIKQWVDLQNKEDLILSVVDLHAITLPQDPKELYQNILRMTATLLACGVDTSKLILFQQSQVYQHTELAWIFSCICTMARLAHLPQFKEKSATLKDVPLGLYIYPVLQAADIMLYKATHVPVGDDQLQHLELSQDLARMFNRRYGLTFPSPHAIVTGTSKIKSLRNPSKKMSKSDPDAKSRICLTDSADEIARKIRKSVTDCTSAITFDPDERPGVSNLVMMHSSLSGKTVEVILKEVEGMDTLQYKSLVADCVISFISPISQRIKELMEEPQYLRNVLDVGTSRAMEIASCTMEEVRGKMGIQLLHTEAHELATSNRSMYKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LI43</accession>
    <name>A0A1Y1LI43_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PPYR_13417</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01054946">
        <property type="protein sequence ID" value="JAV73319.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1LI43"/>
    <dbReference type="InParanoid" id="A0A1Y1LI43"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379:SF121">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379">
        <property type="entry name" value="KRAB AND ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13909">
        <property type="entry name" value="zf-H2C2_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="126"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="154"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="266"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="294"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="322"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="JAV73319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0793797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="346" mass="40318" checksum="0EBD222576CD9F21" modified="2017-08-30" version="1">MLTAIGSAYIHGIVKYEPQDDIETSLSRTEIDGEIKQLGFVPDDSQDCLPIEPDLDVKEEYNCYPQVKEEKNIVTRVASPVSLDTTPLITTHVSVTASEDGKRNVLPFDVDKDITKGNLDESSIEYKCQQCDYNATKKRNLGYHMRAHHGLKEFKCKQCSFTTKWKSNLGKHTKGFHGSEKFICYHCNFSTKWKPNLIEHIQSFHCSKNCVRQQYNCINRGKSNLIRYEAGCCGKDFECRICSFTTNRKLELVDHVKEYHSVTECYKCERCSFTCKLRQHLTKHLNRRHGVEQFRCQQCNYATKAKRYLSRHVKRHHCLGKFKCQQCNFVTHTNRYLVRHVKRSHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LIF6</accession>
    <name>A0A1Y1LIF6_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_01579</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01054753">
        <property type="protein sequence ID" value="JAV73422.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1LIF6"/>
    <dbReference type="InParanoid" id="A0A1Y1LIF6"/>
    <dbReference type="OrthoDB" id="6673704at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23992">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.20">
        <property type="entry name" value="Pheromone/general odorant binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006170">
        <property type="entry name" value="PBP/GOBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036728">
        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01395">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036312546" evidence="1">
        <location>
            <begin position="23"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="JAV73422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0804609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="137" mass="15704" checksum="894B0060D5CAAB89" modified="2017-08-30" version="1">MNNSIVIFALFVIITGYPSDFSETVEECIKKEELGNETLKIYQYLQHPMVPSDDDEYNKFFGCYWKSLGLLDKFGNVDTEKVDKYFEDWRGNKIPTKSRADAISKCKHFHGGSCGQRAVKIYNCINLHFSELGLLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LJP4</accession>
    <name>A0A1Y1LJP4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acyl-aliphatic-L-amino acid amidohydrolase</fullName>
            <ecNumber evidence="3">3.5.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">N-acyl-L-amino-acid amidohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PPYR_12083</name>
        <name evidence="14" type="ORF">PPYR_12084</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M20A family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.14" evidence="3"/>
    <dbReference type="EMBL" id="GEZM01054012">
        <property type="protein sequence ID" value="JAV73882.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0795244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0795245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1LJP4"/>
    <dbReference type="InParanoid" id="A0A1Y1LJP4"/>
    <dbReference type="OrthoDB" id="3064516at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004046">
        <property type="term" value="F:aminoacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000019">
        <property type="entry name" value="Aminoacylase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052083">
        <property type="entry name" value="Aminoacylase-1_M20A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010159">
        <property type="entry name" value="N-acyl_aa_amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01880">
        <property type="entry name" value="Ac-peptdase-euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45892">
        <property type="entry name" value="AMINOACYLASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45892:SF1">
        <property type="entry name" value="AMINOACYLASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036696">
        <property type="entry name" value="ACY-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00758">
        <property type="entry name" value="ARGE_DAPE_CPG2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00759">
        <property type="entry name" value="ARGE_DAPE_CPG2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="11">
        <location>
            <begin position="186"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="369"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR036696-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR036696-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="JAV73882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAB0795244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAB0795245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="397" mass="44476" checksum="63F4359705A218C0" modified="2017-08-30" version="1">MNPYRDLDQIAIDNFRKYLRIPTVHPNVNYDECVKFLQGLANDLQLDCQVITIVPKKPIVVMTWIGKNANIPTILLNSHMDVVPAFEENWVHKPFSADIDEEGNIHARGAQDVKSLGIQYLEAIRRLKRFGYQPRRTIHVSFVPDEELGGTDGMKVFVKSEAFEKLRVGFAMDEGIPDEHEFWVYYGEKVSRRLSIHCTGQGGHGGLLLSNTAGEKMTNILKYCYNLREAENLKVGQTGEADDVVSINLTMMGGGVQANVIPSEFVLTFDARVPPGRDLQQFENTVREWCKRSGGGVWVEDFPVDDHAPSTQLDDSNPFWVAFGNVTTNMGVTVRKKVLNASSDARYLRSAGVPTIGFCPHPRTPNRAHKDNEFMNVTALIDGIEVFQKILPAIADV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LWH0</accession>
    <name>A0A1Y1LWH0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dual specificity protein phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.16</ecNumber>
            <ecNumber evidence="4">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PPYR_11528</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="4"/>
    <dbReference type="EC" id="3.1.3.48" evidence="4"/>
    <dbReference type="EMBL" id="GEZM01046136">
        <property type="protein sequence ID" value="JAV77491.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0794689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1LWH0"/>
    <dbReference type="FunCoup" id="A0A1Y1LWH0">
        <property type="interactions" value="494"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1LWH0"/>
    <dbReference type="OrthoDB" id="165342at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033550">
        <property type="term" value="F:MAP kinase tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017017">
        <property type="term" value="F:MAP kinase tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008330">
        <property type="term" value="F:protein tyrosine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043409">
        <property type="term" value="P:negative regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01446">
        <property type="entry name" value="DSP_MapKP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14566">
        <property type="entry name" value="DSP_MKP_classII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.250.10:FF:000054">
        <property type="entry name" value="Dual specificity phosphatase 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008343">
        <property type="entry name" value="MKP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159:SF519">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE MPK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000939">
        <property type="entry name" value="MAPK_Ptase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01764">
        <property type="entry name" value="MAPKPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="9">
        <location>
            <begin position="24"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="7">
        <location>
            <begin position="215"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="8">
        <location>
            <begin position="279"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="177"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="184"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate" evidence="5">
        <location>
            <position position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000939-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="JAV77491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0794689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="435" mass="49005" checksum="B4B3C1982894EC5D" modified="2017-08-30" version="1">MPTAPDSEYEFVSQEWLLAELRSDSKSLVILDCRSSNEYGESHIRDAVNFSIPSIMLRRLAAGKIDLVSTIKCRELKNKICSNYKENLFVLYNELYGVQQHLSDSTLSVLLRRLTQDGCRVVCLEDGFSRFKASYPEWCDSCSELLETTGTLPPAAGPDPLPLMGLRSLRISAPPLHRPHRSCDSLSSAANSSTDSSDTDDRCDSSLGLEDDKEFPVEILPYLFLGNAANSEDSQALARHSIQYVLNVTPDLPNVFEDLGSIKYMQIPITDHWSQNLASHFPQAIEFIDEARSHKKGVLVHCLAGVSRSVTITVAYLMYKCSLNLNDAFNLVRARKSNIAPNFHFMEQLHNFERELKLDVSSQSPSSLMEQIRREQHDVRKVEENRSRQCPNCRLRDDCKCRQHTEFLSPLAHIGVSPDSGIEFDRWSSSATPGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LZ27</accession>
    <name>A0A1Y1LZ27_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Peptidase C1A papain C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_05112</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01045844">
        <property type="protein sequence ID" value="JAV77660.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1LZ27"/>
    <dbReference type="InParanoid" id="A0A1Y1LZ27"/>
    <dbReference type="OrthoDB" id="10253408at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000006">
        <property type="entry name" value="Cathepsin S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036029861" description="Peptidase C1A papain C-terminal domain-containing protein" evidence="5">
        <location>
            <begin position="20"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="Cathepsin propeptide inhibitor" evidence="7">
        <location>
            <begin position="48"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="6">
        <location>
            <begin position="135"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="JAV77660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0802926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="355" mass="39222" checksum="A6B9212D144C8439" modified="2017-08-30" version="1">MKLVLVLLLGAVYVQHTESQFRLPKPIDVVKNAAKPIQSTIKLFTEQFRSFKTQFRKSYASPEEEERKLNVFSRNFEKITQLTKAGALPFVTKVNEYCDLISSEFNKLLNGLKVKRKSGSRRVRRGSLQGGPGHAADSIDWRDKGVVTEIKNQGECASCYAFASTAAVESQTAIKTGKLQDISPQEVLDCSQVEPYENYGCDGGSLEPAYDYIKSKGVVSDQSYPYTATTGEKCNASPDQVSANIKSYVTIQEGDEEALKEALSNIGPIAVGMDASSENWQFYGGGIYYEPDCKSAIENLNHAVTLVGYGEENGMKYWIVKNSYGTSWGENGYAKIARNETNHCGIASYAVYPLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1M6D5</accession>
    <name>A0A1Y1M6D5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein MON2 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PPYR_05484</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MON2 family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01042424">
        <property type="protein sequence ID" value="JAV79865.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01042423">
        <property type="protein sequence ID" value="JAV79866.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000003">
        <property type="protein sequence ID" value="KAB0801130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A1Y1M6D5">
        <property type="interactions" value="1754"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1M6D5"/>
    <dbReference type="OrthoDB" id="294853at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032629">
        <property type="entry name" value="DCB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015403">
        <property type="entry name" value="Mon2/Sec7/BIG1-like_HDS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032691">
        <property type="entry name" value="Mon2/Sec7/BIG1-like_HUS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032817">
        <property type="entry name" value="Mon2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF333">
        <property type="entry name" value="PROTEIN MON2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16213">
        <property type="entry name" value="DCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16206">
        <property type="entry name" value="Mon2_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09324">
        <property type="entry name" value="Sec7-like_HDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12783">
        <property type="entry name" value="Sec7-like_HUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Mon2/Sec7/BIG1-like dimerisation and cyclophilin-binding" evidence="8">
        <location>
            <begin position="12"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Mon2/Sec7/BIG1-like HUS" evidence="6">
        <location>
            <begin position="218"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="Mon2/Sec7/BIG1-like HDS" evidence="5">
        <location>
            <begin position="840"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="domain" description="Mon2 C-terminal" evidence="7">
        <location>
            <begin position="918"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="domain" description="Mon2 C-terminal" evidence="7">
        <location>
            <begin position="1162"/>
            <end position="1631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF09324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="JAV79865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0801130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1642" mass="182909" checksum="59060E687E96821D" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1M6J0</accession>
    <name>A0A1Y1M6J0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Asparagine synthetase [glutamine-hydrolyzing]</fullName>
            <ecNumber evidence="2">6.3.5.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Glutamine-dependent asparagine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PPYR_08773</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">1611_PpyrPB1</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">1611_PpyrPB1</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-aspartate + L-glutamine + ATP + H2O = L-asparagine + L-glutamate + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12228"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58048"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-asparagine biosynthesis; L-asparagine from L-aspartate (L-Gln route): step 1/1.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.4" evidence="2"/>
    <dbReference type="EMBL" id="GEZM01042355">
        <property type="protein sequence ID" value="JAV79914.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01042354">
        <property type="protein sequence ID" value="JAV79915.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01042353">
        <property type="protein sequence ID" value="JAV79916.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01042352">
        <property type="protein sequence ID" value="JAV79917.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1M6J0"/>
    <dbReference type="FunCoup" id="A0A1Y1M6J0">
        <property type="interactions" value="626"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1M6J0"/>
    <dbReference type="OrthoDB" id="409189at2759"/>
    <dbReference type="UniPathway" id="UPA00134">
        <property type="reaction ID" value="UER00195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070981">
        <property type="term" value="P:L-asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00712">
        <property type="entry name" value="AsnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000090">
        <property type="entry name" value="asparagine synthetase [glutamine-hydrolyzing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006426">
        <property type="entry name" value="Asn_synth_AEB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050795">
        <property type="entry name" value="Asn_Synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033738">
        <property type="entry name" value="AsnB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01536">
        <property type="entry name" value="asn_synth_AEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11772">
        <property type="entry name" value="ASPARAGINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11772:SF23">
        <property type="entry name" value="ASPARAGINE SYNTHETASE [GLUTAMINE-HYDROLYZING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001589">
        <property type="entry name" value="Asn_synthetase_glu-h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="8 13" id="KW-0061">Asparagine biosynthesis</keyword>
    <keyword evidence="7 12 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 13" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 12 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="16">
        <location>
            <begin position="2"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="13">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="360"/>
            <end position="361"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for beta-aspartyl-AMP intermediate formation" evidence="15">
        <location>
            <position position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR001589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="JAV79915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAB0797780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="568" mass="65115" checksum="ECDC006EF562E292" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1M8C3</accession>
    <name>A0A1Y1M8C3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytochrome b-c1 complex subunit Rieske, mitochondrial</fullName>
            <ecNumber evidence="11">7.1.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PPYR_14206</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">1611_PpyrPB1</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">1611_PpyrPB1</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a quinol + 2 Fe(III)-[cytochrome c](out) = a quinone + 2 Fe(II)-[cytochrome c](out) + 2 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:11484"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="7.1.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
        <text evidence="11">Binds 1 [2Fe-2S] cluster per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="11">The Rieske protein is a high potential 2Fe-2S protein.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Rieske iron-sulfur protein family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.8" evidence="11"/>
    <dbReference type="EMBL" id="GEZM01037770">
        <property type="protein sequence ID" value="JAV81943.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1M8C3"/>
    <dbReference type="FunCoup" id="A0A1Y1M8C3">
        <property type="interactions" value="1587"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1M8C3"/>
    <dbReference type="OrthoDB" id="1637982at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008121">
        <property type="term" value="F:quinol-cytochrome-c reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03470">
        <property type="entry name" value="Rieske_cytochrome_bc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.270:FF:000001">
        <property type="entry name" value="Cytochrome b-c1 complex subunit Rieske, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.102.10.10:FF:000001">
        <property type="entry name" value="Cytochrome b-c1 complex subunit Rieske, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.270">
        <property type="entry name" value="Ubiquinol cytochrome reductase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037008">
        <property type="entry name" value="bc1_Rieske_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014349">
        <property type="entry name" value="Rieske_Fe-S_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005805">
        <property type="entry name" value="Rieske_Fe-S_prot_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004192">
        <property type="entry name" value="Rieske_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006317">
        <property type="entry name" value="Ubiquinol_cyt_c_Rdtase_Fe-S-su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015248">
        <property type="entry name" value="UQCRFS1_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01416">
        <property type="entry name" value="Rieske_proteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10134">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09165">
        <property type="entry name" value="Ubiq-Cytc-red_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02921">
        <property type="entry name" value="UCR_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00162">
        <property type="entry name" value="RIESKE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81502">
        <property type="entry name" value="ISP transmembrane anchor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Rieske" evidence="13">
        <location>
            <begin position="171"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="JAV81943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAB0792247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="267" mass="29232" checksum="41C0D827D291B71C" modified="2017-08-30" version="1">MLQSSKLSCYVRSANQVVSNNLKQATPNAVIPKKAITKPPLEVHTSYTLSRQLPLGKFVTVSGPAVSTQVRFAHTDIKVPDFSSYRRTQVIDPNVKSSSTVDERQNMTYLIAGGGLIGTMYSAKALVTKFISSMSASADVLALAKIEVKLSEVPEGKSVTFKWRGKPLFIRHRTAEEIEAERSVPVSSLRDPQHDDERVKRPEFLIVLGVCTHLGCVPIANAGDFGGYYCPCHGSHYDASGRIRKGPAPLNLEIPDYEFVDDLVIVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1MEQ2</accession>
    <name>A0A1Y1MEQ2_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Peptidyl-prolyl cis-trans isomerase E</fullName>
            <shortName evidence="10">PPIase E</shortName>
            <ecNumber evidence="4 10">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PPYR_10288</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">1611_PpyrPB1</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">1611_PpyrPB1</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the cis-trans isomerization of proline imidic peptide bonds in proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the cyclophilin-type PPIase family. PPIase E subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4 10"/>
    <dbReference type="EMBL" id="GEZM01033286">
        <property type="protein sequence ID" value="JAV84282.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1MEQ2"/>
    <dbReference type="FunCoup" id="A0A1Y1MEQ2">
        <property type="interactions" value="1560"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1MEQ2"/>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01926">
        <property type="entry name" value="cyclophilin_ABH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12347">
        <property type="entry name" value="RRM_PPIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000010">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000321">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016304">
        <property type="entry name" value="PPIE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034168">
        <property type="entry name" value="PPIE_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001475">
        <property type="entry name" value="PPI_cyclophilin_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 10" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="RRM" evidence="14">
        <location>
            <begin position="7"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="13">
        <location>
            <begin position="141"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="110"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR001475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="JAV84282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAB0796227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="299" mass="33141" checksum="847AE8D942470761" modified="2017-08-30" version="1">MGTNNKRTIYVGGLAEEVDEKILNAAFIPFGDVVDIQIPLDYETEKHRGFAFIEFECAEDAAAAIDNMNDSELFGRTIRVNLAKPQRIKEGSTRPVWAEDTWLQQHAGETLKGSETEGGTTETNSIEKTREQKKLKNPQVYFDINIGKTEVGRITMMLRVDVVPRTAENFRCLCTHEKGYGFQGSTFHRVIPDFMCQGGDFTHHNGTGGKSIYGRKFSDENFILKHTSAGTLSMANSGANTNGSQFFICTAKTDWLDGKHVVFGHVISGMDVVRRIERCGTKSGTPTEKITIAACGEIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1MR71</accession>
    <name>A0A1Y1MR71_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PPYR_06374</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S3 family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01025134">
        <property type="protein sequence ID" value="JAV87568.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000004">
        <property type="protein sequence ID" value="KAB0800634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1MR71"/>
    <dbReference type="FunCoup" id="A0A1Y1MR71">
        <property type="interactions" value="1560"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1MR71"/>
    <dbReference type="OrthoDB" id="1713558at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042176">
        <property type="term" value="P:regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050756">
        <property type="entry name" value="CSN3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013586">
        <property type="entry name" value="PSMD3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057985">
        <property type="entry name" value="TPR_PSMD3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758:SF2">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3/COP9 SIGNALOSOME COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08375">
        <property type="entry name" value="Rpn3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25573">
        <property type="entry name" value="TPR_PSMD3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="4">
        <location>
            <begin position="244"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="453"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="459"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="JAV87568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0800634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="492" mass="55988" checksum="116A33DE108F7888" modified="2017-08-30" version="1">MVANENTDVEMKNADSPPGPEAGDSKRDVDLQSLIDVREQARQIEKAVTNKENRFVSRVLRSLPTTRKKLNGVVLRGLINQLYPALERDGLLCFLDEPITGADSDTTTRGRTAIKTPVAEVDVYIHMLILVRLIDTNKLDEATRCSQALMTKITGQNRRTLDWIAAKCYFYHSRVAELTNKLESIRGFLHARLRTATLRNDFEGQAVLINCLLRNYLHYSLYDQADKLVSKCVFPETASNNEWARFLYYLGRIKAARLEYSVAYKHLVQAVRKAPQSAAIGFRQTVQKLLVVVELLLGDIPERQVFRQASMRHSLGPYFQLTQAVRMGNLQRFGEVLENFGPQFLQDHTFTLITRLRHNVIKTAIRSIGLSYSRIAPQDIAKKLGLDSAEDAEFIVAKAIRDGVIEATLDPEGGYMRSKESSDIYCTKEPQNAFHQRIAFCLDLHNQSVKAMRYPPKSYGKELESAEERREREQQDLELAKEMAEEDDDGFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1MRR0</accession>
    <name>A0A1Y1MRR0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Phosphatidylinositol-4,5-bisphosphate 4-phosphatase</fullName>
            <ecNumber evidence="4 11">3.1.3.78</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PPYR_10855</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
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        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <location>
            <begin position="57"/>
            <end position="130"/>
        </location>
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        </location>
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        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
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        </source>
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            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="JAV86057.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAB0799504.1"/>
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            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="218" mass="25475" checksum="D3A213B59A7791A7" modified="2017-08-30" version="1">MRDKDQASPRSSRSESKSPASDDGEKKRKRSVSNESKSSGSKSRSRSRSYSMDRDDYRLHIADIGDHVRRSDLEKVFAPFGNLKELWLTHSSPIFGFAVFKTKESSMAALKGADGVNVGGSRIRVTHARPRTRGQGRRFFHPNMRCYQCGYAGHFYRDCPDLDDSKGYDSRSARRNSRRDRDRDYYSDRDYGRRRQRSSRRYDDYDGYRRSGGRRYRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1N1P3</accession>
    <name>A0A1Y1N1P3_PHOPY</name>
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            <fullName evidence="14">Endonuclease</fullName>
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        <name evidence="18" type="ORF">PPYR_04843</name>
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        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
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            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
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            <taxon>Lampyrinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">1611_PpyrPB1</strain>
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        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">1611_PpyrPB1</strain>
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        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>Mg(2+)</name>
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        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the DNA/RNA non-specific endonuclease family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="InParanoid" id="A0A1Y1N1P3"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA/RNA_endonuclease_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044929">
        <property type="entry name" value="DNA/RNA_non-sp_Endonuclease_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001604">
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040255">
        <property type="entry name" value="Non-specific_endonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13966:SF5">
        <property type="entry name" value="ENDONUCLEASE G, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13966">
        <property type="entry name" value="ENDONUCLEASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Endonuclease_NS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00892">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="His-Me finger endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NUCLEASE_NON_SPEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="6 14" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 14" id="KW-0540">Nuclease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="DNA/RNA non-specific endonuclease/pyrophosphatase/phosphodiesterase" evidence="16">
        <location>
            <begin position="107"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="ENPP1-3/EXOG-like endonuclease/phosphodiesterase" evidence="15">
        <location>
            <begin position="108"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR640255-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU366055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="JAV91821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAB0802657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="328" mass="37310" checksum="3D120E62A236581A" modified="2017-08-30" version="1">MQLVLITIKSNLETVKLKKMKNFRMWSARLSKYATVISIGCSGYFLGTYYERSKQISTESRYLRSPAIFSNVFAATPLTPATLGSNNANRISEIMKYGFPGLDNIRSFDNFILSYDRKTRVAHWVFEHLTKENMKFNEGVDRALCEFQADKSIHHYFRSENTDYKGSGYDRGHLAAAGNHKASQKYVEQTFLLSNMAPQVGVGFNRHSWNRLEKYVRKKAKVNNNVYCCTGPLYLPRKESDGKKYVKYEVIGANNVAVPTHFFKVILFETTNGILELEAYVMPNQAIDDAIPLASFQVPPDSIERAAGLLFFDNIGKTKISRINGKNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1N783</accession>
    <name>A0A1Y1N783_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ethanolamine kinase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_04323</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the choline/ethanolamine kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.82" evidence="5"/>
    <dbReference type="EMBL" id="GEZM01010845">
        <property type="protein sequence ID" value="JAV93771.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01010844">
        <property type="protein sequence ID" value="JAV93772.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="JAV93773.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1N783"/>
    <dbReference type="FunCoup" id="A0A1Y1N783">
        <property type="interactions" value="1813"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1N783"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004305">
        <property type="term" value="F:ethanolamine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05157">
        <property type="entry name" value="ETNK_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603">
        <property type="entry name" value="CHOLINE/ETHANOALAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603:SF66">
        <property type="entry name" value="ETHANOLAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01633">
        <property type="entry name" value="Choline_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="1" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="2" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="JAV93772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0802137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="350" mass="40918" checksum="13F72C9820C403F2" modified="2017-08-30" version="1">MEGSNGVPHLKLSVDENRLTEGARKIIEEIRPFWNLENVQFDVLTNGYTNKLIRCREENGPPHEAVLVRVYGNKTELMIDRNAEKRTILILNNLGLPPRLYASFENGLAYEYIPGRTLNCNTIRQPEIYKLIATHLAYMHKVQLPNDLAKKPMLWEKLEDFFNMLPETFSDSAKHERYNATIMPRCKMQDEINMLKKKLIKLNSPLVFTHNDLLLNNIIYSQEKGSVEFIDFEYSGVNYQAFDVGNHFNEFVGFENIDYSNYPDKELQWNWLRAYLSELHNSEEISDRDIHKLYVQANKFALASHMFWGVWALLQAEYSTIDFDFMGYAAIRLNEYAAKKEAFLALNYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1N8L9</accession>
    <name>A0A1Y1N8L9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">E3 ubiquitin-protein ligase APD1-4 middle domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PPYR_00445</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01010796">
        <property type="protein sequence ID" value="JAV93828.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1N8L9"/>
    <dbReference type="InParanoid" id="A0A1Y1N8L9"/>
    <dbReference type="OrthoDB" id="6435218at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032010">
        <property type="entry name" value="APD1-4_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032008">
        <property type="entry name" value="APD1-4_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39077">
        <property type="entry name" value="DUF4793 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39077:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE APD1-4 MIDDLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16041">
        <property type="entry name" value="APD1-4_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16040">
        <property type="entry name" value="APD1-4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="578"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="domain" description="E3 ubiquitin-protein ligase APD1-4 N-terminal" evidence="3">
        <location>
            <begin position="91"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="E3 ubiquitin-protein ligase APD1-4 middle" evidence="4">
        <location>
            <begin position="485"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="JAV93828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0803475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="597" mass="67472" checksum="CC06F1B8EE94028D" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1NIE1</accession>
    <name>A0A1Y1NIE1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PPYR_09451</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">1611_PpyrPB1</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">1611_PpyrPB1</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="GEZM01001649">
        <property type="protein sequence ID" value="JAV97621.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1NIE1"/>
    <dbReference type="FunCoup" id="A0A1Y1NIE1">
        <property type="interactions" value="1332"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1NIE1"/>
    <dbReference type="OrthoDB" id="8693905at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06610">
        <property type="entry name" value="STKc_OSR1_SPAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000043">
        <property type="entry name" value="serine/threonine-protein kinase OSR1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000114">
        <property type="entry name" value="serine/threonine-protein kinase OSR1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000068">
        <property type="entry name" value="STE20/SPS1-related proline-alanine-rich protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Kinase_OSR1/WNK_CCT"/>
    </dbReference>
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        <property type="entry name" value="Prot_kinase_dom"/>
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        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
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        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF16">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12202">
        <property type="entry name" value="OSR1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="10 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
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    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="123"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="421"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="JAV97621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAB0798458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="584" mass="65038" checksum="23986388E347B252" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1NJB4</accession>
    <name>A0A1Y1NJB4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ribonucleoside-diphosphate reductase</fullName>
            <ecNumber evidence="3">1.17.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_08814</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ribonucleoside diphosphate reductase small chain family.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1" evidence="3"/>
    <dbReference type="EMBL" id="GEZM01003553">
        <property type="protein sequence ID" value="JAV96735.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="interactions" value="538"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="10248373at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribonucleoside-diphosphate reductase subunit M2 B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="entry name" value="Ribonucleotide Reductase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR000358">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0215">Deoxyribonucleotide synthesis</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="JAV96735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0797821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="368" mass="42098" checksum="C0E9ACFDE2C17C4C" modified="2017-08-30" version="1">MPYVNGKENVDITSSPAKTVLSENAINIIHNSTKKSNVNELKSKPKFDPQLEPLLRDNPRRFVVFPIEYPDIWARYKEAEASFWTTEEVDLSHDLEHWRGLSDDERYFISHVLAFFAASDGIVNENLVERFSQEVQVTEARCFYGFQIAIENVHSEMYSLLIDTYISEPKQKDHLFNAIETMPCVTKKADWALNWIASEDATFAERVVAFAAVEGIFFSGSFASIFWLKKRGLMPGLTFSNELISRDEGLHCAFACLMFSHLVQKPTKERVTSIIRDAVQIEQEFLSEAIPVSLIGMNCTLMCQYIEYVADRLLLDLGCDKIYDVTNPFDFMNKISIEGKTNFFEKKVGEYQKNGVVDNISISFDADF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1NJK9</accession>
    <name>A0A1Y1NJK9_PHOPY</name>
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        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PPYR_03644</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GEZM01001199">
        <property type="protein sequence ID" value="JAV98071.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01001198">
        <property type="protein sequence ID" value="JAV98072.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01001197">
        <property type="protein sequence ID" value="JAV98073.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1NJK9"/>
    <dbReference type="InParanoid" id="A0A1Y1NJK9"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000249">
        <property type="entry name" value="facilitated trehalose transporter Tret1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050549">
        <property type="entry name" value="MFS_Trehalose_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021:SF24">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="37"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="296"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="360"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="395"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="428"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="461"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="39"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="JAV98071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0791844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="529" mass="59077" checksum="C7770BE40E3735B0" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N3ZZ07</accession>
    <name>A0A5N3ZZ07_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">LRRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_15397</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01001578">
        <property type="protein sequence ID" value="KAB0790268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N3ZZ07"/>
    <dbReference type="InParanoid" id="A0A5N3ZZ07"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001360">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050541">
        <property type="entry name" value="LRR_TM_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369">
        <property type="entry name" value="ANTIGEN BSP, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369:SF213">
        <property type="entry name" value="INSULIN LIKE GROWTH FACTOR BINDING PROTEIN ACID LABILE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="629"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="633"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0790268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="656" mass="75461" checksum="C48AE3EB3FD936AB" modified="2020-02-26" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A0R0</accession>
    <name>A0A5N4A0R0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">FLYWCH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PPYR_14871</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000703">
        <property type="protein sequence ID" value="KAB0790848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A0R0"/>
    <dbReference type="InParanoid" id="A0A5N4A0R0"/>
    <dbReference type="OrthoDB" id="10029846at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018289">
        <property type="entry name" value="MULE_transposase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007588">
        <property type="entry name" value="Znf_FLYWCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47160:SF10">
        <property type="entry name" value="MULE TRANSPOSASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47160">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04500">
        <property type="entry name" value="FLYWCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10551">
        <property type="entry name" value="MULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FLYWCH-type" evidence="4">
        <location>
            <begin position="7"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="MULE transposase" evidence="5">
        <location>
            <begin position="188"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0790848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="469" mass="53713" checksum="08E1159F92C3A644" modified="2020-02-26" version="1">MDVEILSEKGKQKFTENGFIYVFDTFSKSDNSIKFWRCEKRKECKARVHTRNGEVLKKINDHCHDSSAVSVEVAQVVTKVKKRAVETIEGTIQVINECMVNTTQAAQAVLPNTCSLRKLVRRKRNEVNAAPPNPLTLADLLLPDDYKTYKLRVNVTENFLLADNQDGAERILIFGRQTWLPYLETSSVWYADGTFSIAPPLFSQVYTLMGVINNGVHPICYALLPNKMRGTYQRMFELLKELLPNLNPLAINCDFEHAAFTAMKTSFPNVNIYGCFFHMAQNMKKKLGEMGVTREYNNDPQFALNARMVTSLAFVPPARLDDAIEVVSNALPGNLQPLLDWFEDSYVGRMNRRGNGRRQPLFPIEMWNLYQRTLNGQDRTNNHAEAAHRRLKSEVGMVHPSIWKFIDALRKVQKGRDAYYEQLVAGNAPPLKLRKYRNADARILNLVTNFNDDSNILEYLRGLAHNYHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A1M1</accession>
    <name>A0A5N4A1M1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sulfotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_02968</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfotransferase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A1M1"/>
    <dbReference type="SMR" id="A0A5N4A1M1"/>
    <dbReference type="InParanoid" id="A0A5N4A1M1"/>
    <dbReference type="OrthoDB" id="205623at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11783">
        <property type="entry name" value="SULFOTRANSFERASE SULT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="3">
        <location>
            <begin position="58"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0791168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="327" mass="37728" checksum="96F457A32156D02D" modified="2020-02-26" version="1">MLPCERKIKNEELSELVKRTLTSPVIDEYLLFGPESTCLPSYYGSGADAVGNFQIRNGDVIVASFPKSGTTWLQEMVWLLKNHLDYDAAQVEIYKRFAKLELPGIGDPNQPSRDNSVEELNRLSGPRLIKTHLPYSLLPRRTRDGSEIPKIIYIMRNPKDAFISYYHFGRAALGWRASKEELAKLFMGGTILYGPYWKSALGYWNLRHSPNVLILKYEEMVKDLRAVIRRTCEFLEREPLTHEQMEKLCGHLSFNSMKDNSAVNYSTMLSQRKNFAVNPAPFMRCGKVGQYRWEMSSQMIAEFDEWIERSIEGTDFSKKYACFGKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A1N4</accession>
    <name>A0A5N4A1N4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_03040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A1N4"/>
    <dbReference type="InParanoid" id="A0A5N4A1N4"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000063">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0791240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="308" mass="34854" checksum="93013F6709873C98" modified="2020-02-26" version="1">MDAYSSWLELVSIKNKSAHEVIQKLKSIFSKFGSPDTLVCDNVPFNSYSFGEFSKEWNFNVVCRSPNYPKSNGLAEKAVDIAKKLLKKSLEEGKDIFDALIQYRNSPLKYLDYSPAQLLMSRICRTKLPISADLLKPTLCKGVREKLQLRLANNEKYYNKTATDLKTLKPDQNVTVFNHIDKTWTPGKIIDIAQNPRSYKVLDENGAVVIRNRFDIRESLNSYKSVVNNDFDMLNSRNCSLQANSDINISKHESSSDLVQQSKRSSLEIESPLNNAQSSSNYESASNPPALKSKVSGRIIKKPKMLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A3D0</accession>
    <name>A0A5N4A3D0_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_03579</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A3D0"/>
    <dbReference type="InParanoid" id="A0A5N4A3D0"/>
    <dbReference type="OrthoDB" id="8195082at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051217">
        <property type="entry name" value="Insect_Cuticle_Struc_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236:SF86">
        <property type="entry name" value="CCP84AC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236">
        <property type="entry name" value="STRUCTURAL CONTITUENT OF CUTICLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="50"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0791779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="204" mass="22638" checksum="30E66A78C0DEC6D2" modified="2020-02-26" version="1">MSRKKTTSIRHCLYTTMQTALITIALIAAACAAPQLRHGPRVQQFVNPADESQQFQQSQPQPAQFSQTPQFPSLRRPGADPIQDDYEIYQNQNAKYEFSSNIDDRISDLTNQRQEVRDGAAVKGSYSYSDGYFKIKVDYIADDQGYRVTGMEAVPLEGPKVDPKGTASVSSTAHGSQLRYRVASIPVPAAQPERFPPSPQRTLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-06-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A3K1</accession>
    <name>A0A5N4A3K1_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_03703</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A3K1"/>
    <dbReference type="InParanoid" id="A0A5N4A3K1"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024349332" evidence="1">
        <location>
            <begin position="21"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0791903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="129" mass="14106" checksum="1354669204115883" modified="2020-02-26" version="1">MNYLVFILSFVAFQVIGSSAASNAVKLKKTIDCINEKMANLTAPEQVAFAVFMKSVHSLLKPLHLQDDLMHCLEDLGDPPVALEAVHTAECIGNIIVDLATPTQDLLYGSMNGLMKLYMKNVPSLKHCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A421</accession>
    <name>A0A5N4A421_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_14018</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A421"/>
    <dbReference type="InParanoid" id="A0A5N4A421"/>
    <dbReference type="OrthoDB" id="76453at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051756">
        <property type="entry name" value="Centrosomal_MT-associated"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19336:SF9">
        <property type="entry name" value="SPINDLE POLE BODY PROTEIN PPC89"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19336">
        <property type="entry name" value="UNCHARACTERIZED DUF1167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="81"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="349"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="584"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="45"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="631"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="81"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="592"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0792057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="742" mass="82147" checksum="19CD1E3DA56D7C15" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A4B8</accession>
    <name>A0A5N4A4B8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PPYR_14122</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 9 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A4B8"/>
    <dbReference type="InParanoid" id="A0A5N4A4B8"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000085">
        <property type="entry name" value="SIX homeobox 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031701">
        <property type="entry name" value="SIX1_SD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10390">
        <property type="entry name" value="HOMEOBOX PROTEIN SIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10390:SF44">
        <property type="entry name" value="SIX HOMEOBOX 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16878">
        <property type="entry name" value="SIX1_SD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5 9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0371">Homeobox</keyword>
    <keyword evidence="8 9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="11">
        <location>
            <begin position="115"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="9">
        <location>
            <begin position="117"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAB0792163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="170" mass="20226" checksum="F3179A4809624443" modified="2020-02-26" version="1">MCEALHQRGDVERLATFLWSLPPSELLRGNESILRARAVVAFHRGSFHELYAILESHSFNPRWHTDLQNLWFRAHYNEAEKIRGRPLGAVDKYRLRKKYPLPKTIWDGEETVYCFKERSRNALKECYARNKYPTPDEKRALAKRTGLTLTQVSNWFKNRRQRDRTPQSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A577</accession>
    <name>A0A5N4A577_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_14434</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A577"/>
    <dbReference type="InParanoid" id="A0A5N4A577"/>
    <dbReference type="OrthoDB" id="5915502at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38640">
        <property type="entry name" value="GEO09659P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38640:SF1">
        <property type="entry name" value="GEO09659P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0792475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="163" mass="18803" checksum="38AA3F9516ACFF0D" modified="2020-02-26" version="1">MSTEGYDVNQSSQSDLVRKCEQNFYLTATIQGRLSYLLMSIHAVTPSICARLTTYNPGPILFYNMLYGVAAHLHCRPHMQLLGSFHRVAFSILGSIAFNHSCMMGFQWVVNTFPMRPYLRTFMGFFVGRLMMVYFLAYMYHVDSRSVVGQIVERDANYESMYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A6V0</accession>
    <name>A0A5N4A6V0_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_12608</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0792988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A6V0"/>
    <dbReference type="InParanoid" id="A0A5N4A6V0"/>
    <dbReference type="OrthoDB" id="6784842at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0792988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="405" mass="44387" checksum="3698394A1F5F766C" modified="2020-02-26" version="1">MENQIYNSTQICEFVACATCFGLSTGTILMGYVALHDPLKSTVVALPAAFGVLTLINLLVSTTNEPLLWKFWTPVALLAAMLFYVSTGCLVWTNVATGYYELLLIAYGFTGSVFLFDVVDMARLQCFYKETVPLQHHVSPKLSDKSVQVQIETEDVKSISEQPEHVDDNKCARGETRKFNRRPTPSHGGTFHVSKNIVPLSTMRSEDESDHSCECHPRSIAGPRRSSQAGVRQPLATYQLKCADCECPCNTDEYVYGGQRKKLAAIQRSTSGSRNKYSAGSCPTSNSTSEQHSPVSDNGCECTTSSFATNYTTSSVERTIVFQSFNPNSGSVWSNSWVPGADRPCPILPGSVADCTQPTTINIERCITIKQAGSYVVSPQFKTGTLTRTLPVSRIARRGTQCTQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A7F5</accession>
    <name>A0A5N4A7F5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Putative nuclease HARBI1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Harbinger transposase-derived nuclease</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PPYR_12870</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Transposase-derived protein that may have nuclease activity. Does not have transposase activity.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HARBI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A7F5"/>
    <dbReference type="InParanoid" id="A0A5N4A7F5"/>
    <dbReference type="OrthoDB" id="6740069at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026103">
        <property type="entry name" value="HARBI1_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF289">
        <property type="entry name" value="DDE TNP4 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02086">
        <property type="entry name" value="PUTNUCHARBI1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="13">
        <location>
            <begin position="216"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAB0793250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="419" mass="47793" checksum="1E5FFA723866EBD8" modified="2020-02-26" version="1">MGSNRFLNFRSLSKLSLRFDCDILLYTLFYFLYTPSNFLPICALMAHSSDEGSSFDGEDLLHTSSNTSDENEELIVELNRRVRHPRTFRSRPDNFTKWTEEEFRMRFRLCKATTSFLLTLIQDQLVHRSNRNHAVSAMNQLLLTLRLYATGSMLIAVGDFIGVDKSTASRIVKKVTTAICTLAGIYIQMPRMENAIRRNQLAFYNIARFPRVIGAIDCTHVRIQSPGGDNAEYFRNRKGYFSFNIQVVGDASLRILDVVARWPGSTHDQTVFNNSRIHARLETNEFGNSIILGDSGYAIKQYLITPLLNPHTEGEQLFNEAQIRSRNPIERLFGVWKRRFPILSLGIRLSLETTQSVIIACAVLHNIAQERNEDGPLVDPDVILPNNDDEIDDVVNVPEAGNINNNFRQTFIDYFSSLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-06-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A7G9</accession>
    <name>A0A5N4A7G9_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_12891</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A7G9"/>
    <dbReference type="InParanoid" id="A0A5N4A7G9"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0793271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="69" mass="8091" checksum="4F356C8446FB23A5" modified="2020-02-26" version="1">MFLCVIVVSNVFGDRSLFLALQKHRRSLSHFVLALSARRKIKVSDFWQLEIRLGVWDLITEWASVLFVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A8I7</accession>
    <name>A0A5N4A8I7_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_13266</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A8I7"/>
    <dbReference type="FunCoup" id="A0A5N4A8I7">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A8I7"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39948">
        <property type="entry name" value="GEO11419P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39948:SF1">
        <property type="entry name" value="GEO11419P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0793646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="70" mass="7709" checksum="4264C0B9ACB5DC2F" modified="2020-02-26" version="1">MGNPINSILWLIVLIFISFLVACFCAGFYILCHPLSVCIPPLKGLSDILLSGVQFPHYCAERMMSGSSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A8M0</accession>
    <name>A0A5N4A8M0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TMC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PPYR_13284</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A8M0"/>
    <dbReference type="InParanoid" id="A0A5N4A8M0"/>
    <dbReference type="OrthoDB" id="1936208at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038900">
        <property type="entry name" value="TMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012496">
        <property type="entry name" value="TMC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23302:SF43">
        <property type="entry name" value="TMC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23302">
        <property type="entry name" value="TRANSMEMBRANE CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07810">
        <property type="entry name" value="TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="407"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="447"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="484"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="579"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="623"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="683"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="domain" description="TMC" evidence="7">
        <location>
            <begin position="515"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0793664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="815" mass="94638" checksum="E98492326D112587" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A9D9</accession>
    <name>A0A5N4A9D9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Transmembrane protein 47</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_13547</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TMEM47 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A9D9"/>
    <dbReference type="FunCoup" id="A0A5N4A9D9">
        <property type="interactions" value="66"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A9D9"/>
    <dbReference type="OrthoDB" id="8655982at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005911">
        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.150:FF:000028">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015664">
        <property type="entry name" value="P53_induced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004031">
        <property type="entry name" value="PMP22/EMP/MP20/Claudin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14399:SF5">
        <property type="entry name" value="CELL JUNCTION PROTEIN VAB-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14399">
        <property type="entry name" value="P53-INDUCED PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00822">
        <property type="entry name" value="PMP22_Claudin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0965">Cell junction</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="83"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0793927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="205" mass="23225" checksum="9857548209D25363" modified="2020-02-26" version="1">MLVIRREYQLAIQKRKYRTVIAFICGLIVIILMIMGLASTDWLMADGWRQGLFMYCIADDAQQPLPFNVQEASGCYPSRNENYIHAAAGLCIITLITDLVATVLTGLGLRTKEHHTKYKYYRFGVIVMGLSLVSILIALIIYPVCFAAELNLGNRKIWEFGWAYGVGWGAAIFLFGGVVLLLCDKESEEIYYKERKIVHDNDSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A9U6</accession>
    <name>A0A5N4A9U6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PPYR_13704</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">1611_PpyrPB1</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ZNF598/HEL2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0794084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A9U6"/>
    <dbReference type="FunCoup" id="A0A5N4A9U6">
        <property type="interactions" value="279"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A9U6"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16615">
        <property type="entry name" value="RING-HC_ZNF598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057634">
        <property type="entry name" value="PAH_ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041888">
        <property type="entry name" value="RING-HC_ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044288">
        <property type="entry name" value="ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059042">
        <property type="entry name" value="Znf_C2H2_ZNF598"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22938:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE ZNF598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22938">
        <property type="entry name" value="ZINC FINGER PROTEIN 598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23202">
        <property type="entry name" value="PAH_ZNF598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25447">
        <property type="entry name" value="RING_ZNF598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23208">
        <property type="entry name" value="zf_C2H2_ZNF598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="14">
        <location>
            <begin position="13"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="107"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="481"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="826"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="528"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="577"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="625"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="828"/>
            <end position="839"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00035113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAB0794084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="845" mass="94565" checksum="61E87F649E1188C8" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AB61</accession>
    <name>A0A5N4AB61_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein MEMO1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_11285</name>
        <name evidence="3" type="ORF">PPYR_11358</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MEMO1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0794446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0794519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AB61"/>
    <dbReference type="FunCoup" id="A0A5N4AB61">
        <property type="interactions" value="1931"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AB61"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07361">
        <property type="entry name" value="MEMO_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.830.10">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00055">
        <property type="entry name" value="MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002737">
        <property type="entry name" value="MEMO1_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04336">
        <property type="entry name" value="AmmeMemoSam_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11060">
        <property type="entry name" value="PROTEIN MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11060:SF0">
        <property type="entry name" value="PROTEIN MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01875">
        <property type="entry name" value="Memo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0794446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0794519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="295" mass="33154" checksum="83FB8A27BAA062F9" modified="2020-02-26" version="1">MSVRRATHAGSWYADSGPELSRQLEHWLHQADFRHGPARAIIAPHAGYQYCGACAGHAYRQISPVAIRRIFILGPSHHARLSGCALSIAQKCKTPLTDLHVDNQVNADLEMSGQFEWMDLDTDENEHSIEMHLPYIAKIMDTYKDQFTIVPILVGSLSPEQEATYGRLLSSYLADPQNLFVISSDFCHWGQRFRYTYHDRACGNIQQSIEALDRAGMSIIENLNPTEFTNYLKEYGNTICGRHPIGILLQAVQELLRNDGTICANLKFLKYAQSSQCRNVNDSSVSYASAALVFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ABS6</accession>
    <name>A0A5N4ABS6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PPYR_11616</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0794777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ABS6"/>
    <dbReference type="InParanoid" id="A0A5N4ABS6"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14733">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002780">
        <property type="entry name" value="Protein CBR-EOR-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF29">
        <property type="entry name" value="MYONEURIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BTB" evidence="9">
        <location>
            <begin position="32"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="452"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="480"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="535"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="565"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="593"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="629"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="641"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0794777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="822" mass="94556" checksum="03FABF3A313F6921" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AC36</accession>
    <name>A0A5N4AC36_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PPYR_11729</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">1611_PpyrPB1</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0794890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AC36"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.370:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.70:FF:000004">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000026">
        <property type="entry name" value="Transposon Ty3-G Gag-Pol polyprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="13">
        <location>
            <begin position="315"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="14">
        <location>
            <begin position="1085"/>
            <end position="1240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="215"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1363"/>
            <end position="1387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="222"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="252"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="265"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAB0794890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1418" mass="163332" checksum="25C6541EC59BF5BF" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-06-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ACK0</accession>
    <name>A0A5N4ACK0_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_11817</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0794978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ACK0"/>
    <dbReference type="InParanoid" id="A0A5N4ACK0"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0794978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="136" mass="15501" checksum="36A124F68DC1C8F4" modified="2020-02-26" version="1">MVDDACNEILQIDISDNVKPDIIIDDTIDHKIKEDVVSLYNNCYKNALIPSSPETDYEMRITLKSPYVVQKILPNDRYLIKDIEGFQVTRIPFEGIFDPSRLKHWMHNNCESASDSEGENHSVEVEDNLSSGSAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ACP0</accession>
    <name>A0A5N4ACP0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PPYR_11929</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0795090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ACP0"/>
    <dbReference type="FunCoup" id="A0A5N4ACP0">
        <property type="interactions" value="63"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4ACP0"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04269">
        <property type="entry name" value="ZnMc_adamalysin_II_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000002">
        <property type="entry name" value="Disintegrin and metalloproteinase domain-containing protein 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.70.10:FF:000001">
        <property type="entry name" value="Disintegrin and metalloproteinase domain-containing protein 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.70.10">
        <property type="entry name" value="Disintegrin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006586">
        <property type="entry name" value="ADAM_Cys-rich"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018358">
        <property type="entry name" value="Disintegrin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001762">
        <property type="entry name" value="Disintegrin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036436">
        <property type="entry name" value="Disintegrin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013111">
        <property type="entry name" value="EGF_extracell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034027">
        <property type="entry name" value="Reprolysin_adamalysin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905">
        <property type="entry name" value="ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905:SF237">
        <property type="entry name" value="MIND-MELD, ISOFORM J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08516">
        <property type="entry name" value="ADAM_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00200">
        <property type="entry name" value="Disintegrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07974">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01421">
        <property type="entry name" value="Reprolysin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00289">
        <property type="entry name" value="DISINTEGRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00608">
        <property type="entry name" value="ACR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00050">
        <property type="entry name" value="DISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57552">
        <property type="entry name" value="Blood coagulation inhibitor (disintegrin)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00427">
        <property type="entry name" value="DISINTEGRIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50214">
        <property type="entry name" value="DISINTEGRIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="4 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="640"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12B" evidence="13">
        <location>
            <begin position="116"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="Disintegrin" evidence="12">
        <location>
            <begin position="326"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="11">
        <location>
            <begin position="560"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="934"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="945"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="961"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1057"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1084"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="386"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="587"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAB0795090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1101" mass="121055" checksum="5EB5A422627D3449" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ACR4</accession>
    <name>A0A5N4ACR4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidase S54 rhomboid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_11966</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0795127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ACR4"/>
    <dbReference type="InParanoid" id="A0A5N4ACR4"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051739">
        <property type="entry name" value="Rhomboid_IM_Serine_Proteases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45840:SF10">
        <property type="entry name" value="RHOMBOID PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45840">
        <property type="entry name" value="RHOMBOID-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="226"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="256"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="8">
        <location>
            <begin position="101"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="40"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0795127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="296" mass="33297" checksum="FB43F5FC371A5122" modified="2020-02-26" version="1">MSSKPDNIISAISPSRMEPKTQAATPESTTEERHCLVPPLNSSMVPPSASQRPELSNPKPWYRQYPPPFGILLTSVLQLIMYGVATDKIERILRFEPNNHTEAWRYVTYMFIHRNLFHVLINVVIQCLFAFTLEKYQNRLLVLTLYFGSGAIGALSSSCVRPDLVVGASAGVYGLLISNLSHIALNYNSTKYKLWAVLTVIIIVASDATFYLIYARNQENVIISEGAHIGGGIAGLILGLLLYRSKDEESKKRNRFIFWSIFAIFAILMSLLVAINFMIKKCTPAHRLRVSYTYVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ADF1</accession>
    <name>A0A5N4ADF1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Death domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PPYR_12184</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0795345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ADF1"/>
    <dbReference type="FunCoup" id="A0A5N4ADF1">
        <property type="interactions" value="395"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4ADF1"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070976">
        <property type="term" value="F:TIR domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035325">
        <property type="term" value="F:Toll-like receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050830">
        <property type="term" value="P:defense response to Gram-positive bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002755">
        <property type="term" value="P:MyD88-dependent toll-like receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043123">
        <property type="term" value="P:positive regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008063">
        <property type="term" value="P:Toll signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034142">
        <property type="term" value="P:toll-like receptor 4 signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="entry name" value="Toll/interleukin-1 receptor homology (TIR) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000488">
        <property type="entry name" value="Death_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017281">
        <property type="entry name" value="Myelin_different_resp_MyD88"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15079">
        <property type="entry name" value="MYD88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15079:SF3">
        <property type="entry name" value="MYELOID DIFFERENTIATION PRIMARY RESPONSE PROTEIN MYD88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00531">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00005">
        <property type="entry name" value="DEATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00255">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="Toll/Interleukin receptor TIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50017">
        <property type="entry name" value="DEATH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50104">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0395">Inflammatory response</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Death" evidence="4">
        <location>
            <begin position="49"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="TIR" evidence="5">
        <location>
            <begin position="157"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0795345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="419" mass="47293" checksum="2E460CEF05357377" modified="2020-02-26" version="1">MNARSFDLAMAGDSYEVSIKALSTKTIALLSTLLNPPKIILTEDGLPRDWNGLAELVGISGECIPSLQNAKDHTKKLLSVWHEKDQKSSTICNLLTHLEKLDRFDVVEDVQYFIDEDIKAYQPTCEKDKLSNVNPGLDSLVLTREDIVRLENGLGPQHYDAFVLFADEDANFATELIDKMENDYKLKLCTRDRDLVAGIFEHEAIMKLISLRCDRLVPVLSPAFLDSYSNKFICSFAQSLGIEQQTRKIVPCLYTPCQVPSDLKCLFMLDYQRQGKFSNFWKRVRDSIKMVNQSPVPTSPIYRSSSQQIPQTPPIAETNHIAIVPDITHESSLLKPKKNGVKFSSMINLPSIENDEIVSSISETDSLPAQIVEVKKSKIKTGWLKKILSNKNHKCSDANHESHKKNLFRSIKRKVAIAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ADR1</accession>
    <name>A0A5N4ADR1_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_12295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0795456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ADR1"/>
    <dbReference type="InParanoid" id="A0A5N4ADR1"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0795456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="120" mass="14251" checksum="788D19D326A19094" modified="2020-02-26" version="1">MITDHANMWQNRNRTHKSSGFSISNHSKFCIKSVRNCILLGRFYKLIVILVIYCKNVCFTFCTLHLQSRFESRLWYKMRINYKYVVEKKTDEVKRSMETPYYRPSSIKTVAVGIVAHCKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AER1</accession>
    <name>A0A5N4AER1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PPYR_09855</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NFX1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0795794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AER1"/>
    <dbReference type="FunCoup" id="A0A5N4AER1">
        <property type="interactions" value="2340"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AER1"/>
    <dbReference type="OrthoDB" id="536399at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06008">
        <property type="entry name" value="NF-X1-zinc-finger"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034078">
        <property type="entry name" value="NFX1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000967">
        <property type="entry name" value="Znf_NFX1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12360:SF1">
        <property type="entry name" value="NF-X1-TYPE ZINC FINGER PROTEIN NFXL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12360">
        <property type="entry name" value="NUCLEAR TRANSCRIPTION FACTOR, X-BOX BINDING 1 NFX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01422">
        <property type="entry name" value="zf-NF-X1"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00438">
        <property type="entry name" value="ZnF_NFX"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="825"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="10">
        <location>
            <begin position="97"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="767"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="8"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0795794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="844" mass="95329" checksum="2F545C04801E1839" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AF24</accession>
    <name>A0A5N4AF24_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CTLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_09996</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0795935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AF24"/>
    <dbReference type="InParanoid" id="A0A5N4AF24"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22249">
        <property type="entry name" value="UDM1_RNF168_RNF169-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040067">
        <property type="entry name" value="WDR47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057749">
        <property type="entry name" value="WDR47_COR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19863">
        <property type="entry name" value="NEMITIN (NEURONAL ENRICHED MAP INTERACTING PROTEIN) HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19863:SF11">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 47-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25602">
        <property type="entry name" value="WDR47_COR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTLH" evidence="3">
        <location>
            <begin position="93"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="453"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="573"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="538"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="453"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="477"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="588"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="612"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0795935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="694" mass="78044" checksum="F241119B4EEEF4F7" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AFW4</accession>
    <name>A0A5N4AFW4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MD-2-related lipid-recognition domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_10250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AFW4"/>
    <dbReference type="InParanoid" id="A0A5N4AFW4"/>
    <dbReference type="OrthoDB" id="6764543at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036846">
        <property type="entry name" value="GM2-AP_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63707">
        <property type="entry name" value="Ganglioside M2 (gm2) activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024359691" description="MD-2-related lipid-recognition domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0796189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="183" mass="20169" checksum="EB7E2E72362D7D84" modified="2020-02-26" version="1">MYSLTAIHLLSLLLLCDSQMMGPPGTMLFDAIGPCENNPGGDVEFDLNLQSTDSKGGKILSMNVSTKVPLDDTVTYLANVLKWEDNGWKYANKRSGNLCPDLMRFASKIWKLLQEHSVPKIPDECSLEPGDYRVENVTAATSDLDIPVTYYGKTRLDVSIYQGSTLLACVVFDGVSQKPARPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AIC7</accession>
    <name>A0A5N4AIC7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PPYR_08104</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">1611_PpyrPB1</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Microsome membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 15">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AIC7"/>
    <dbReference type="InParanoid" id="A0A5N4AIC7"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
        <property type="entry name" value="Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291:SF189">
        <property type="entry name" value="CYTOCHROME P450 4C3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 14 15" id="KW-0349">Heme</keyword>
    <keyword evidence="11 14 15" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0492">Microsome</keyword>
    <keyword evidence="12 15" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="10 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="14">
        <location>
            <position position="437"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAB0797110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="493" mass="56719" checksum="088AC7AE94CA5EB3" modified="2020-02-26" version="1">MGIGIILFAVLALFLLFQYHWKRRHLYKISMKLEGPPALPLVGNGLSFLHKQEDFLGVISKIISTYTGPTRFWLGPHLLLLFSHPEHVEKILLSTKLSHKHELYDFIKIYIGEGLVSSSGEKHKRYRKIIQRMINTKFILGNMDTFQKHINIFLEKLSSRCGKCTFDIHEAIHLCCADIIGETVLGMQMKAQYGQNMDFVHASAEVYTVAYERIMKPWYHPDIIYNFTSGKKKQSRIISISYNFIKRHITNAIERVRTAKEDKNGIRPLIDQIADVIDKDTSVMDETDFVYNMYTLYLASEDTLTIIIAMLCVCLGMYPQYQKRAAEEVRTLHANTSGTIAYDNLSGLPYLDMCIKDVLRLIPIAPLIARRANEDFAIDDYVIPKDCGIIVSIFDLHRNPKHWENPSHFHPDHFLPDAVNSRHPYAYIPFSAGPRSCVGKQLAYSSLKLIMVNILQRFEIEADGKFPDIVLRSDITTRSVSGYNVRLKERVWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AJ35</accession>
    <name>A0A5N4AJ35_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SHSP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PPYR_08303</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2 4 5">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AJ35"/>
    <dbReference type="InParanoid" id="A0A5N4AJ35"/>
    <dbReference type="OrthoDB" id="1431247at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06526">
        <property type="entry name" value="metazoan_ACD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055269">
        <property type="entry name" value="Alpha-crystallin/HSP_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001436">
        <property type="entry name" value="Alpha-crystallin/sHSP_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45640:SF13">
        <property type="entry name" value="HEAT SHOCK PROTEIN 22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45640">
        <property type="entry name" value="HEAT SHOCK PROTEIN HSP-12.2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036514">
        <property type="entry name" value="Sm_HSP_B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00299">
        <property type="entry name" value="ACRYSTALLIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0346">Stress response</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="SHSP" evidence="7">
        <location>
            <begin position="56"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="161"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="171"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="185"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR036514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR036514-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0797309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="196" mass="22363" checksum="41CD2ADA88326C53" modified="2020-02-26" version="1">MASYFDQWNQSVVRPSQPVDQRYGVVLESGDLVSPLIIPLNAVYLGKSVSPNYQSSWRSFRYDRRSKVNVNRNQFEINLNVQHFDANELTVKITGNAIIIEGNHDEKHDQHGSVSRQFKRKYLVPNGHNVNKATSVLSGDGILIVSIPRNESVVEERVIPILQGESQDEEQDKRLDEQRSQADEKCEDDQVDEKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AJX2</accession>
    <name>A0A5N4AJX2_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF4758 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_08645</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AJX2"/>
    <dbReference type="FunCoup" id="A0A5N4AJX2">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AJX2"/>
    <dbReference type="OrthoDB" id="8192055at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024466519" description="DUF4758 domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="427"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="122"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="346"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="393"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="437"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="493"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="539"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="590"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="600"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="621"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="682"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="765"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="779"/>
            <end position="788"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0797652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="813" mass="87855" checksum="1BDC79FEA2A5EDCF" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AK55</accession>
    <name>A0A5N4AK55_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_08713</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AK55"/>
    <dbReference type="InParanoid" id="A0A5N4AK55"/>
    <dbReference type="OrthoDB" id="6682367at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902936">
        <property type="term" value="F:phosphatidylinositol bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1200">
        <property type="entry name" value="Alpha-tocopherol transfer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.20">
        <property type="entry name" value="N-terminal domain of phosphatidylinositol transfer protein sec14p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174">
        <property type="entry name" value="ALPHA-TOCOPHEROL TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174:SF216">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00180">
        <property type="entry name" value="CRETINALDHBP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="142"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0797720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="340" mass="39480" checksum="38110410B9264EA6" modified="2020-02-26" version="1">MRQVHVSDYLKCTAPIWLDTKVTLNPTTTLSMYRKIPDDLQKTAECKLNEVTSRIENDITQMKEWIAKQPHLNIEIDDQFILTLLRCCKFSLQRTKEKIDTYYTARSIMPEIFSNRDPYLPEIQHLFNSRCIALPLPNLDPDDGSRIIFINYSSSLDPNLVSLRNLDKVNYMILDILIREDDDMIINGLKLITHCKDLSVRFLNELTPLYMKRHVYLVNAFPLRLQAVRVVNCPAPFAFAYSIFKTFTTSKIGQRMIMVSETNVPELCRQSPHLFPKEMGGNNGSIQELSGTWKRKVESYREWFLQEEAKKSDESLRTEPPKTALDLFGADGTFRKLEID</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ALI5</accession>
    <name>A0A5N4ALI5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase</fullName>
            <ecNumber evidence="4 14">4.2.1.134</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PPYR_09159</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">1611_PpyrPB1</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>a very-long-chain (3R)-3-hydroxyacyl-CoA = a very-long-chain (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:45812"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:83728"/>
            <dbReference type="ChEBI" id="CHEBI:85440"/>
            <dbReference type="EC" id="4.2.1.134"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Endoplasmic reticulum membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the very long-chain fatty acids dehydratase HACD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.134" evidence="4 14"/>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ALI5"/>
    <dbReference type="FunCoup" id="A0A5N4ALI5">
        <property type="interactions" value="846"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4ALI5"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102158">
        <property type="term" value="F:very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030497">
        <property type="term" value="P:fatty acid elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007482">
        <property type="entry name" value="Tyr_Pase-like_PTPLA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11035">
        <property type="entry name" value="VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11035:SF3">
        <property type="entry name" value="VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04387">
        <property type="entry name" value="PTPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11 14" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="7 14" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 14" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="109"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="165"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00036671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAB0798166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="263" mass="30323" checksum="F9DA7F440429EA89" modified="2020-02-26" version="1">MTLKNRKSNNSNYGKSFNFPPFMQYIQRWQAAIATMLKNKSSVYLFFYNLIETVGWSYILYLLVIHFTFATDGSLYESIKTPLFIFQNAAVLEIFHAVFRLVPSSPSVTIQQVFSRVMLVCGVLMLSRDAQLGIGLPLILAAWSVTEIIRYGYYTLNLVNAVPQFLLWLRYTLFIGLYPLGVTGELLCIYAACMEFRRNNYGVVTLPNYLNVTFNYPYLLMFLMALYIPLFPPLYMHMFGQRKKVLGKTSTTKVSTRVSKKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ALZ6</accession>
    <name>A0A5N4ALZ6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_09365</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ALZ6"/>
    <dbReference type="InParanoid" id="A0A5N4ALZ6"/>
    <dbReference type="OrthoDB" id="422206at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015232">
        <property type="term" value="F:heme transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097037">
        <property type="term" value="P:heme export"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049680">
        <property type="entry name" value="FLVCR1-2_SLC49-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10924:SF4">
        <property type="entry name" value="GH15861P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10924">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="130"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="209"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="261"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="327"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="351"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="386"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="418"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="40"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0798372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="452" mass="50216" checksum="E66378CEB663CD12" modified="2020-02-26" version="1">MMHYQQVSTVQTDLPLNGDADAHFELEEEKCKVYKKRWFMLFMFFAVSVSCIMNIMQYAIIADVIVKYYGVTYMAVNWSSTIYLLMYLVLGFPSTFILERWGLRVTTLMGMGFTTLGTWIKVGAVSPDRYWVLMLGQVIISISKVVVMPVPPKLAAVWFPAKEVSSACSISVIGIQMGLAVGFLVPPFFFQSGAQGEDDIAGSLYRMNISLAVVDTAILVVLLIFFKGAPPSPPSIAQSKIEKDKGFLEMAKIIVSNRTNIFLIISFGIVIGLLLTISTLLNQIILKHYHDGREDAGFIGLVMVLSGMVGTLSCGVILDRYGKFQQAALLLSILGACSMLCYTFAIHKGILLAYFITAIFGFSTLGMQVTGLELGAELTYPIPQGITAGILMMSTQAFGIALTYLYSQIFKAYGDFFANLTMFFIYVVEFILMCTLKYNLRRRAIEKTRSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AM98</accession>
    <name>A0A5N4AM98_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_09427</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AM98"/>
    <dbReference type="InParanoid" id="A0A5N4AM98"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="218"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="364"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0798434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="384" mass="41448" checksum="DB8B536AEA1E52A2" modified="2020-02-26" version="1">MADFNKEKRKLIYCISQWTPDLDVQEASEDIVDIHRITFCLQFDIDVSDLTVLFQIMGYTLEEFERVPAIEENGEAASSTGQISTSRVQLICSKSGMKSTLTKTLKSCQCPNTQDLDKGQSWFVTGCAPSSSQSTVSSSACSLIPTISKCKASIVGHLIDKAISVIKNKDTRDTDTPLNLSQNALLTRHRSLDTLKSKEGSKLLSGNLSKELSWEVDPSTSPPTQASSPLPDLTRTLSGLSLDANKKATLIRHLSTIHDLVKQSLEIAGPSSTSIKKTQKRKVSDIKPEGHLPNGAGPSTPRKTPNRRLLPLAAKRCGIPTPTFQKVVPRIASPSNAVGVKSRLKVSSSVSAKPTGISSLYRTASKPATASTVTKCKNPAFGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AMA8</accession>
    <name>A0A5N4AMA8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PPYR_09478</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AMA8"/>
    <dbReference type="InParanoid" id="A0A5N4AMA8"/>
    <dbReference type="OrthoDB" id="6591996at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045596">
        <property type="term" value="P:negative regulation of cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000478">
        <property type="entry name" value="Zinc finger protein 133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001498">
        <property type="entry name" value="Zinc finger protein 404"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000912">
        <property type="entry name" value="Zinc finger protein 660"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000634">
        <property type="entry name" value="Zinc finger X-chromosomal protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24381:SF393">
        <property type="entry name" value="CHROMATIN-LINKED ADAPTOR FOR MSL PROTEINS, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24381">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="87"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="117"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="145"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="173"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="201"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="229"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="257"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="285"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="304"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="457"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="312"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="464"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0798485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="522" mass="58703" checksum="407755699C0DDFC2" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AMC4</accession>
    <name>A0A5N4AMC4_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PPYR_09351</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AMC4"/>
    <dbReference type="InParanoid" id="A0A5N4AMC4"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015280">
        <property type="term" value="F:ligand-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.820">
        <property type="entry name" value="Acid-sensing ion channel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF243">
        <property type="entry name" value="PICKPOCKET 12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="4 12" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="10 12" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAB0798358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="382" mass="43591" checksum="97B2D3581BCCC70A" modified="2020-02-26" version="1">MSKTKQTSLVTSEMIDRKLLNEKINNYLQQCTLHGLKYVGNQQLCWIERLFWLAAFIAASFLSGYFIITIVNNYNDRIIISINPRPINADRLPFPTITVCDMNRANKNRALKADDPFHKRCLGVLCDAKDPHGDDLLNARPAPIEQVHFINFTKRVGRKCYRSNKILILRPYEDLLKDRRPYNAEKWAVETGFSPNATNETIPWRLIGSGLTIMLKTDVDNYFCSSTNSAGFKISIADPLELPLGEGLITILPGFKIEIAISPLIKDARTSLTHDTTAASRWCHFSNERKLKLYKSYSLLKCLMECQINYTTEMCNCVPYYALSNRTSPICEQRHKACQNQVSDLRANAYQTAMNMIFARPNLTSALLTDGYLAISQTYRNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-06-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4APP5</accession>
    <name>A0A5N4APP5_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_07190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4APP5"/>
    <dbReference type="InParanoid" id="A0A5N4APP5"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0799310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="115" mass="12536" checksum="9C80D8444DCB8D04" modified="2020-02-26" version="1">MDNKLMHSVLSGISFKSGLLSTRQSIRSGPNADLSTLWLLWPAPNYRPYSTRSLHTISSEGHAGIINTTSKVADPHHSLNSIGSSSIRYSLSNQREEDIFMIASALVSPITQGQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AQC2</accession>
    <name>A0A5N4AQC2_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carboxylesterase type B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_07442</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AQC2"/>
    <dbReference type="FunCoup" id="A0A5N4AQC2">
        <property type="interactions" value="70"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AQC2"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="225"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="265"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="47"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0799562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="745" mass="83893" checksum="B0CACE4E57D3B5D8" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AS12</accession>
    <name>A0A5N4AS12_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_07878</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AS12"/>
    <dbReference type="InParanoid" id="A0A5N4AS12"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF158">
        <property type="entry name" value="GH23626P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024387920" description="Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein" evidence="3">
        <location>
            <begin position="19"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="4">
        <location>
            <begin position="314"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="547"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0799998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="611" mass="68021" checksum="870A41668CEF6F41" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ATB8</accession>
    <name>A0A5N4ATB8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">JmjC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_06218</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000004">
        <property type="protein sequence ID" value="KAB0800478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ATB8"/>
    <dbReference type="FunCoup" id="A0A5N4ATB8">
        <property type="interactions" value="1290"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4ATB8"/>
    <dbReference type="OrthoDB" id="415358at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461:SF99">
        <property type="entry name" value="BIFUNCTIONAL PEPTIDASE AND (3S)-LYSYL HYDROXYLASE JMJD7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="1">
        <location>
            <begin position="124"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0800478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="347" mass="40958" checksum="B618FAF083B27283" modified="2020-02-26" version="1">MCYYEKTLKNCLNVLQEETKELLHFHTKVPCVDIEANNPQWSWSIYRKYVAKNMPVVIKNACRDWRARKLWNIDYFLQKIPDKDVTVAITPNGYADGVIAENNTDFFAMPEERTMRMSEFLSNMTAPKKNFVCYIQKQNSNLLEDFKELINDVDIELKWAKDIFAKSLDAVNFWMGDERAVTSMHKDPYENIYCVISGYKDFILIPPTDLPHVPYKYYPVGTFKNVSTDHYEIEPKLRNGGGDCDHFIPKPQIRGCQEIETKLENSKYEMLNWVSIDPSRPDTDLYPQFRNANVYKVRINEGDCLYLPSLWFHHVQQSHGCIAVNYWYDMDFDLKYCYYKMLECLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ATT6</accession>
    <name>A0A5N4ATT6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cyclic nucleotide-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_06493</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000004">
        <property type="protein sequence ID" value="KAB0800754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ATT6"/>
    <dbReference type="InParanoid" id="A0A5N4ATT6"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098855">
        <property type="term" value="C:HCN channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003254">
        <property type="term" value="P:regulation of membrane depolarization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035725">
        <property type="term" value="P:sodium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.630">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051413">
        <property type="entry name" value="K/Na_HCN_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45689:SF14">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45689">
        <property type="entry name" value="I[[H]] CHANNEL, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="202"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0800754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="335" mass="39003" checksum="00D1B5491B3F06FA" modified="2020-02-26" version="1">MYRTISIYQKNVLCGLIVLVAIVIGIVLHWITCMLYALPRMIKILSVGDHSDYWMDMEGSKLTDTDSLVAIYIQCFFRASCFFFNVDHGGKLPKTYIDLVLSISTSIIGYVLMAILLILILQYVCSGGSAESKYQEIVSQVQEYMRYKQLPCDIQNRIMTCYEYRFRKKYFREEVIKATMSDRLRREINVYNYRRLIDTVSLFKGVPDQVVVDIVNCLRHDIFLPNDIIMKANTIGDCMYFLSSGTVCVITPTGREVCHLYDGAFFGEIALLQKDQKRIATVYALEICEVYRLERKYFQHCFASNMELCRKLQRVADERREQTALIEDLQNQYLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AUZ6</accession>
    <name>A0A5N4AUZ6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Isoleucine--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="4">6.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Isoleucyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PPYR_05501</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">1611_PpyrPB1</strain>
            <tissue evidence="20">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>tRNA(Ile) + L-isoleucine + ATP = L-isoleucyl-tRNA(Ile) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:9666"/>
            <dbReference type="Rhea" id="RHEA-COMP:9695"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78528"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.5"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Part of a multisubunit complex that groups tRNA ligases for Arg (RARS1), Asp (DARS1), Gln (QARS1), Ile (IARS1), Leu (LARS1), Lys (KARS1), Met (MARS1) the bifunctional ligase for Glu and Pro (EPRS1) and the auxiliary subunits AIMP1/p43, AIMP2/p38 and EEF1E1/p18.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.5" evidence="4"/>
    <dbReference type="EMBL" id="VVIM01000003">
        <property type="protein sequence ID" value="KAB0801147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AUZ6"/>
    <dbReference type="FunCoup" id="A0A5N4AUZ6">
        <property type="interactions" value="1840"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AUZ6"/>
    <dbReference type="OrthoDB" id="1706657at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004822">
        <property type="term" value="F:isoleucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006428">
        <property type="term" value="P:isoleucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07961">
        <property type="entry name" value="Anticodon_Ia_Ile_ABEc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00818">
        <property type="entry name" value="IleRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000414">
        <property type="entry name" value="Isoleucine--tRNA ligase, cytoplasmic-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000004">
        <property type="entry name" value="Isoleucyl-tRNA synthetase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000050">
        <property type="entry name" value="Isoleucyl-tRNA synthetase,cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02003">
        <property type="entry name" value="Ile_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033709">
        <property type="entry name" value="Anticodon_Ile_ABEc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002301">
        <property type="entry name" value="Ile-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023586">
        <property type="entry name" value="Ile-tRNA-ligase_type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00392">
        <property type="entry name" value="ileS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42780:SF1">
        <property type="entry name" value="ISOLEUCINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42780">
        <property type="entry name" value="SOLEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19302">
        <property type="entry name" value="DUF5915"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00984">
        <property type="entry name" value="TRNASYNTHILE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="12 17" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="9 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 17" id="KW-0436">Ligase</keyword>
    <keyword evidence="8 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10 17" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="18">
        <location>
            <begin position="25"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="19">
        <location>
            <begin position="702"/>
            <end position="851"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00063494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00069879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAB0801147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1218" mass="140402" checksum="0F001DDF2CE21537" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AV62</accession>
    <name>A0A5N4AV62_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_05578</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000003">
        <property type="protein sequence ID" value="KAB0801224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AV62"/>
    <dbReference type="FunCoup" id="A0A5N4AV62">
        <property type="interactions" value="34"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AV62"/>
    <dbReference type="OrthoDB" id="6371055at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062129">
        <property type="term" value="C:chitin-based extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008010">
        <property type="term" value="F:structural constituent of chitin-based larval cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050468">
        <property type="entry name" value="Cuticle_Struct_Prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380">
        <property type="entry name" value="CUTICLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380:SF234">
        <property type="entry name" value="CUTICULAR PROTEIN 97EA, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0193">Cuticle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024272459" evidence="3">
        <location>
            <begin position="18"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="23"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="117"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="150"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="267"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0801224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="333" mass="35753" checksum="0EBFC577ADD67A4D" modified="2020-02-26" version="1">MIAKIVIVIAFACLTIAQDFDYDEGPQPRPAPTRIRPGFSGTSPSKPSAPIAILKQINRHNEDGSYTYGYESADGSFKIETKLPTGEVKGKYGFVDDVGKLRVVEYGATKYGFEPQGEGITVAPPTLVDETTLKDGSLNPEYADQYYQPEPAPRPAPRPKPRPQPSFDGYSSPLQFAPAPQRSASPGPARPQQGFGGASLTTDIEYGAPQPRPAPPSRSFAPQPTKHGFRPASQSFSFEPAPIEEQENYAEPAPAPRPVPVQSFRPAPQPRPAPLPPFRPAPPSPQYQSAPAPRPGPVTRQSGGGPGILDQLAKDYAIPNGAPALHDISFGYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AVR1</accession>
    <name>A0A5N4AVR1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">ArfGAP with SH3 domain, ANK repeat and PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PPYR_05778</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">1611_PpyrPB1</strain>
            <tissue evidence="19">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000003">
        <property type="protein sequence ID" value="KAB0801424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AVR1"/>
    <dbReference type="FunCoup" id="A0A5N4AVR1">
        <property type="interactions" value="1514"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AVR1"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08834">
        <property type="entry name" value="ArfGap_ASAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07604">
        <property type="entry name" value="BAR_ASAPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13251">
        <property type="entry name" value="PH_ASAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11821">
        <property type="entry name" value="SH3_ASAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000006">
        <property type="entry name" value="Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000012">
        <property type="entry name" value="Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000322">
        <property type="entry name" value="Uncharacterized protein, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043593">
        <property type="entry name" value="ASAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035836">
        <property type="entry name" value="ASAP1-like_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037844">
        <property type="entry name" value="PH_ASAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45854:SF3">
        <property type="entry name" value="ARFGAP WITH SH3 DOMAIN, ANK REPEAT AND PH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45854">
        <property type="entry name" value="ASAP FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16746">
        <property type="entry name" value="BAR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 11" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 12" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PH" evidence="17">
        <location>
            <begin position="306"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="Arf-GAP" evidence="18">
        <location>
            <begin position="427"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="11">
        <location>
            <begin position="632"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="16">
        <location>
            <begin position="965"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="714"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="842"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="883"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="246"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="722"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="750"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="896"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="939"/>
            <end position="950"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAB0801424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="21">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1029" mass="115085" checksum="9E0DEF270E081677" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AWC3</accession>
    <name>A0A5N4AWC3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7869 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_03825</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0801639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AWC3"/>
    <dbReference type="InParanoid" id="A0A5N4AWC3"/>
    <dbReference type="OrthoDB" id="6781302at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057191">
        <property type="entry name" value="DUF7869"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10773:SF19">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10773">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25273">
        <property type="entry name" value="DUF7869"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7869" evidence="2">
        <location>
            <begin position="498"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0801639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="708" mass="81983" checksum="9AEB40FB8F09CA22" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AZA8</accession>
    <name>A0A5N4AZA8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_04873</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AZA8"/>
    <dbReference type="InParanoid" id="A0A5N4AZA8"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511">
        <property type="entry name" value="PROTEIN CBG23764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511:SF12">
        <property type="entry name" value="RHO TERMINATION FACTOR N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="His-Me finger endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="391"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0802687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="859" mass="98676" checksum="BD21AA15BB53FBF8" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AZE3</accession>
    <name>A0A5N4AZE3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Brix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_04895</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AZE3"/>
    <dbReference type="FunCoup" id="A0A5N4AZE3">
        <property type="interactions" value="1091"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AZE3"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045112">
        <property type="entry name" value="PPAN-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12661">
        <property type="entry name" value="PETER PAN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12661:SF5">
        <property type="entry name" value="SUPPRESSOR OF SWI4 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="2">
        <location>
            <begin position="27"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0802709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="436" mass="50024" checksum="761BD08C6F16281E" modified="2020-02-26" version="1">MVKKKKGRSVKRNPNVNSEPEELTQAPHSFIIQRGLTQGHIIELTRDFRKLMEPFTAKSLQEHKKNTIKDFVSVAGLLHVTHLCIFSQTEVGMYFKVGRLPRGPTLTFKVQNFSLAKDVVSSLKKQLVVEKAFKHSPLIILNSFSSEKAHMKLMASMFQNMFPKINLTNVDLNKIRRCVLLNYDPSTDLIDFRHYIIKIVPVGVSKGVKKVIQGKIPDLSKCDDISEFFTRAGTLSESEMEDDPNSHITVNQKLVSRGNVEQGQSAIKLTELGPRMTLQLMKVEDGLLDGIVLYHHLIHKTEEEKLEIQRKRDSKRKLKEKRKKIQEANKKRKEIEKEELKQKSLKGMHANVPKTTEKNSLEENDDDVQYYRDEVGEEPDKGTFNHRFIIHGHYIGKTGNNCVSFTFYNEVEYLYAVESGCGSATLFFIYKIGNEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AZU1</accession>
    <name>A0A5N4AZU1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxypeptidase Q</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">Plasma glutamate carboxypeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">PPYR_05022</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">1611_PpyrPB1</strain>
            <tissue evidence="24">Whole body</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="20">Homodimer. The monomeric form is inactive while the homodimer is active.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Lysosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase M28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AZU1"/>
    <dbReference type="InParanoid" id="A0A5N4AZU1"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070573">
        <property type="term" value="F:metallodipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03883">
        <property type="entry name" value="M28_Pgcp_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000036">
        <property type="entry name" value="Carboxypeptidase Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.30:FF:000009">
        <property type="entry name" value="Carboxypeptidase Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039866">
        <property type="entry name" value="CPQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12053:SF3">
        <property type="entry name" value="CARBOXYPEPTIDASE Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12053">
        <property type="entry name" value="PROTEASE FAMILY M28 PLASMA GLUTAMATE CARBOXYPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="18" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="19" id="KW-0458">Lysosome</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="9" id="KW-0645">Protease</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <keyword evidence="11 22" id="KW-0732">Signal</keyword>
    <keyword evidence="14" id="KW-0862">Zinc</keyword>
    <keyword evidence="17" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="22">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024299666" description="Carboxypeptidase Q" evidence="22">
        <location>
            <begin position="20"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="23">
        <location>
            <begin position="268"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00014116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00025833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00033328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KAB0802836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="475" mass="52362" checksum="BF7465EDDA2BA46C" modified="2020-02-26" version="1">MHNILPWLLNLLVLTLVLCNEEDNTIEKCNLSNSIKQEIASYQNIANQIIAAINGKFKNSTYNHLDEFISEFGNRISGSKNLENAIDYMIIKSEMYNLENVHGEDVVVPHWVRGEESATLLHPRVKNLPMLGLGSSVGTPPEGILAKAVVVSSFEELKKISSKVKGKIVVYNQKYTSYGESVIYRRDGASMAAKYGAVATLIESITPFSLATPHTGWQAYADNITKIPTACITREDANMLHGMYKRGKTIYIKLKMEAHFLPPAISRNVVAEIKGTTHPDKVVVISGHIDSWDVGEGAMDDGGGAFISWTALAILKAMGFRAKRTIRTILWTGEEEGYIGAFAYAKEHSNETKNLNFVMESDIGTFTPLGLKYSGLPIVGCIIQEILNLLRELNTTKVLTPADGGPDLTPWLNQGVPGASLDNANERYFWYHHSAADTMDVEEPEPLDKGTALWAAVAYIIADLSFDIPKNLTVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AZY5</accession>
    <name>A0A5N4AZY5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">HTH OST-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PPYR_05062</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AZY5"/>
    <dbReference type="InParanoid" id="A0A5N4AZY5"/>
    <dbReference type="OrthoDB" id="341421at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08824">
        <property type="entry name" value="LOTUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09972">
        <property type="entry name" value="LOTUS_TDRD_OSKAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.610">
        <property type="entry name" value="LOTUS domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041966">
        <property type="entry name" value="LOTUS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025605">
        <property type="entry name" value="OST-HTH/LOTUS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050621">
        <property type="entry name" value="Tudor_domain_containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22948:SF76">
        <property type="entry name" value="FI20010P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22948">
        <property type="entry name" value="TUDOR DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12872">
        <property type="entry name" value="OST-HTH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00567">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50199">
        <property type="entry name" value="Staphylococcal nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51644">
        <property type="entry name" value="HTH_OST"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50304">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0221">Differentiation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0744">Spermatogenesis</keyword>
    <feature type="domain" description="HTH OST-type" evidence="7">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="HTH OST-type" evidence="7">
        <location>
            <begin position="245"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="Tudor" evidence="6">
        <location>
            <begin position="432"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="87"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="187"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="90"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="107"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="150"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="191"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0802876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1163" mass="133172" checksum="54B71F2DBEB6BF40" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B0M1</accession>
    <name>A0A5N4B0M1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_00112</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B0M1"/>
    <dbReference type="InParanoid" id="A0A5N4B0M1"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="3">
        <location>
            <begin position="9"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0803142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="116" mass="13491" checksum="4EF6EC7BA46909BF" modified="2020-02-26" version="1">MTPITAPDTDAKRAYNIAHRSVRNVIERLNGVLKTRFRCLLKHRVLHYSPPVAAKIVNSCAVLHNMCILHGDQALIDDVPEDEYVQDEHDQQQLQNGHERYQGEQVRTRIVRMYFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B1G4</accession>
    <name>A0A5N4B1G4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PPYR_00328</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B1G4"/>
    <dbReference type="FunCoup" id="A0A5N4B1G4">
        <property type="interactions" value="13"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4B1G4"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13195">
        <property type="entry name" value="FERM_C_MYLIP_IDOL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16510">
        <property type="entry name" value="RING-HC_IAPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018980">
        <property type="entry name" value="FERM_PH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041790">
        <property type="entry name" value="MYLIP_FERM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23280">
        <property type="entry name" value="4.1 G PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23280:SF13">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MYLIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01196">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FERM" evidence="10">
        <location>
            <begin position="1"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="280"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAB0803358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="335" mass="37884" checksum="AC5FB64E17555241" modified="2020-02-26" version="1">MFYLHAKLDLIEKRLLVPNWSVVAKLIALIAQAESGDYNPLQPPHHLYMQLSSISSTEVVQKPQDLLQMVISEHEKREGMKPATAQYWLLNEVAALDNFGEEVFTSKSNMGVVIGVGPNGITMYNRNEEKESIPFTAIQSATSHNRCFKLGYLSVDNVEAHLEIKLDSSQTANGLYRAITEKHAFYSCETVGSAVTAQFIRDLKGTIVSIFNEDSTLGKKYVFDIRRTCREVYDNARRALYQESKMFQDIIDGQKPECYEESRRGSSHERLTKIMDAMTCKICMDLQIDTAFLPCAHVVACSSCAARCERCPVCRADITQPQRIYLPEEFNEPIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B1V4</accession>
    <name>A0A5N4B1V4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nematode cuticle collagen N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_00561</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B1V4"/>
    <dbReference type="InParanoid" id="A0A5N4B1V4"/>
    <dbReference type="OrthoDB" id="10061379at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637:SF417">
        <property type="entry name" value="COL_CUTICLE_N DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637">
        <property type="entry name" value="COLLAGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0803591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="245" mass="24827" checksum="B094396AE6D5CC7D" modified="2020-02-26" version="1">MASDKTNISAMLGKVVVILFVVIFICLVEAIVGLYVYKLIKNDFQEDFLKEASNSVSQKEIKELLLEEGYLKDICYGAACIQKHPVGRHPRATARGPPGPPGIPGARGGMGPTGPRGPTGSDGPKGERGDIGDLGSEGDKGSVGDKGAGGEKGDMGPPGPPGIRGESGTIGPPGQKGERGDAGTNGVDGLAGSKGDHGVPGSPGKEGIPGFPGRPGIDGKEGKVGPPGQKGEPAIIDKYPAVYNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B2G1</accession>
    <name>A0A5N4B2G1_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_00703</name>
        <name evidence="2" type="ORF">PPYR_02671</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0805701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B2G1"/>
    <dbReference type="InParanoid" id="A0A5N4B2G1"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0803733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0805701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="71" mass="7973" checksum="D2030DD5F6CE96EC" modified="2020-02-26" version="1">MAIVVGDTVIKTICILHNTIIDKEGHHSFNGMDVPQIPSQCMLRRNRANNPSTRNAKTVRDTFAEYFSLNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B2Y5</accession>
    <name>A0A5N4B2Y5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">1-acylglycerol-3-phosphate O-acyltransferase ABHD5</fullName>
            <ecNumber evidence="5">2.3.1.51</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Abhydrolase domain-containing protein 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">PPYR_00939</name>
        <name evidence="26" type="ORF">PPYR_06531</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">1611_PpyrPB1</strain>
            <tissue evidence="27">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="27" key="2">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="27">1611_PpyrPB1</strain>
            <tissue evidence="27">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Coenzyme A-dependent lysophosphatidic acid acyltransferase that catalyzes the transfer of an acyl group on a lysophosphatidic acid. Functions preferentially with 1-oleoyl-lysophosphatidic acid followed by 1-palmitoyl-lysophosphatidic acid, 1-stearoyl-lysophosphatidic acid and 1-arachidonoyl-lysophosphatidic acid as lipid acceptor. Functions preferentially with arachidonoyl-CoA followed by oleoyl-CoA as acyl group donors. Functions in phosphatidic acid biosynthesis. May regulate the cellular storage of triacylglycerol through activation of the phospholipase PNPLA2. Involved in keratinocyte differentiation. Regulates lipid droplet fusion.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + (9Z)-octadecenoyl-CoA = 1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA</text>
            <dbReference type="Rhea" id="RHEA:37455"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:74938"/>
            <dbReference type="ChEBI" id="CHEBI:74941"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:37456"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = 1-(9Z)-octadecenoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + CoA</text>
            <dbReference type="Rhea" id="RHEA:37443"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57368"/>
            <dbReference type="ChEBI" id="CHEBI:74544"/>
            <dbReference type="ChEBI" id="CHEBI:74928"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:37444"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + (9Z)-octadecenoyl-CoA = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA</text>
            <dbReference type="Rhea" id="RHEA:37131"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:74544"/>
            <dbReference type="ChEBI" id="CHEBI:74546"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:37132"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + hexadecanoyl-CoA = 1-(9Z)-octadecenoyl-2-hexadecanoyl-sn-glycero-3-phosphate + CoA</text>
            <dbReference type="Rhea" id="RHEA:37143"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74544"/>
            <dbReference type="ChEBI" id="CHEBI:74551"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="2">
            <dbReference type="Rhea" id="RHEA:37144"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + octadecanoyl-CoA = 1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phosphate + CoA</text>
            <dbReference type="Rhea" id="RHEA:37147"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57394"/>
            <dbReference type="ChEBI" id="CHEBI:74544"/>
            <dbReference type="ChEBI" id="CHEBI:74552"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:37148"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>1-hexadecanoyl-sn-glycero-3-phosphate + (9Z)-octadecenoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA</text>
            <dbReference type="Rhea" id="RHEA:33187"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:57518"/>
            <dbReference type="ChEBI" id="CHEBI:64839"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:33188"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>1-octadecanoyl-sn-glycero-3-phosphate + (9Z)-octadecenoyl-CoA = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA</text>
            <dbReference type="Rhea" id="RHEA:37163"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:74560"/>
            <dbReference type="ChEBI" id="CHEBI:74565"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:37164"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphate + CoA</text>
            <dbReference type="Rhea" id="RHEA:19709"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57970"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.3.1.51"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:19710"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>eicosanoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate = 1-(9Z)-octadecenoyl-2-eicosanoyl-sn-glycero-3-phosphate + CoA</text>
            <dbReference type="Rhea" id="RHEA:37451"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57380"/>
            <dbReference type="ChEBI" id="CHEBI:74544"/>
            <dbReference type="ChEBI" id="CHEBI:74937"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:37452"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Lipid droplet</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the peptidase S33 family. ABHD4/ABHD5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="27">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.51" evidence="5"/>
    <dbReference type="EMBL" id="VVIM01000004">
        <property type="protein sequence ID" value="KAB0800792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B2Y5"/>
    <dbReference type="FunCoup" id="A0A5N4B2Y5">
        <property type="interactions" value="1551"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4B2Y5"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003841">
        <property type="term" value="F:1-acylglycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000019">
        <property type="entry name" value="1-acylglycerol-3-phosphate O-acyltransferase ABHD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42886:SF29">
        <property type="entry name" value="PUMMELIG, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42886">
        <property type="entry name" value="RE40534P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0221">Differentiation</keyword>
    <keyword evidence="11" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0551">Lipid droplet</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="25">
        <location>
            <begin position="47"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00036296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00038097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00040731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00042413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00045357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00047525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00047849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00048770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00049561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="KAB0800792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="KAB0803969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="353" mass="39618" checksum="AB81A59C40DD513E" modified="2020-02-26" version="1">MLRAVEKKILSYLKTAYRGWYVDIGPTIGAADKIWTISLNADNQNTPIVLLHGLGAGVALWCLNLDAFAATRPVYAIDMIGFGRSSRPAFSTNAMEAEQQFVRSIEEWRHEMNLDKFILLGHSMGGFLAASYSLSHPQRVQHLILADPWGFPEKPPDSERRPLPVWVRAVAYMMSPFNPLAAIRAAGPWGEWIIDKARPDIAKKFTPVVEECGLITQYLYQCNSQTPSGESAFHSMTSGFGWAKNPMVQRIDKLDKNIPITLLYGARSWVDNSAGEIIKSKRVGSYVQLQIISSAGHHVYADKPDVFNKYVIEACKYADRVGNKYEYLKPSNVDKTESDIEEDVEQTFPVIEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B3T4</accession>
    <name>A0A5N4B3T4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA-directed RNA polymerase III subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_01184</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPC7 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B3T4"/>
    <dbReference type="FunCoup" id="A0A5N4B3T4">
        <property type="interactions" value="254"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4B3T4"/>
    <dbReference type="OrthoDB" id="5377312at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024661">
        <property type="entry name" value="RNA_pol_III_Rpc31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15367">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15367:SF2">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11705">
        <property type="entry name" value="RNA_pol_3_Rpc31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="155"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="155"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="199"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0804214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="214" mass="24601" checksum="6A9C8ABDA5F32E4F" modified="2020-02-26" version="1">MAGRGRGRGGRGGNTGSFNREQLNAIGITSNENLPGPIREPPPLFPPLNRKPVPLQESLELDYLLILRQNILDQMQSSGAYLRIPQSKDRLDKRQQEIDKLIAQLPSVKEKFDWNMLPTELRPKLIAKRMKLKESKTVDVNFRLNQLEKLEEKTEKAMDVSVKEEAEPDEEEEEVQENYEDEDMDDGTDYANNYFDNGEAYEDEDDNLDDGPIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B4P0</accession>
    <name>A0A5N4B4P0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_01535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B4P0"/>
    <dbReference type="InParanoid" id="A0A5N4B4P0"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33053">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33053:SF24">
        <property type="entry name" value="TRANSPOSASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0804565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="674" mass="77052" checksum="6B7896B293FC7E9F" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B562</accession>
    <name>A0A5N4B562_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_01702</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B562"/>
    <dbReference type="InParanoid" id="A0A5N4B562"/>
    <dbReference type="OrthoDB" id="7429417at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012464">
        <property type="entry name" value="DUF1676"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07898">
        <property type="entry name" value="DUF1676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024405884" evidence="3">
        <location>
            <begin position="18"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="235"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0804732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="338" mass="37831" checksum="F2EB369BCE1A9B6A" modified="2020-02-26" version="1">MYKIILLVFSIFSCSHAQVRSMGNVREVLKCAARLDYSCILDYAEDAAHNAYANAIKEADMEARKMSIETGRADPEEEQPSSILTTITNIISELPELLRVSLSAALNGEDADNDDKPSDGGNTKDAEEDDDEEEEEDDDDAEEENATEKSKTVGDEIAQCKNGTTCRGRTSKNVAGISSKQSGRSQHNGVARKKKKKEKKKKLKTIIKLIAVAIVLIVKLNIFLKLLAAKLQIKFFLIAVVNLLITLARFWWDLKKGHSDHPQKVIYYEHAQHQHHYDGGDDWHSSGPSESYWGRADADDKKTAQDLAYSKQAPGSITYSRVDDKPNFSWNPWAERSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B5J9</accession>
    <name>A0A5N4B5J9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Acyltransferase 3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_01793</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B5J9"/>
    <dbReference type="FunCoup" id="A0A5N4B5J9">
        <property type="interactions" value="14"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4B5J9"/>
    <dbReference type="OrthoDB" id="10265389at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052728">
        <property type="entry name" value="O2_lipid_transport_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161">
        <property type="entry name" value="O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161:SF0">
        <property type="entry name" value="O-ACYLTRANSFERASE LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024386128" description="Acyltransferase 3 domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="268"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="307"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="403"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="445"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="479"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="522"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="553"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="591"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="domain" description="Acyltransferase 3" evidence="3">
        <location>
            <begin position="220"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0804823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="630" mass="72627" checksum="FC420451C22C96E7" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B690</accession>
    <name>A0A5N4B690_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Helitron helicase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_02033</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0805063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B690"/>
    <dbReference type="InParanoid" id="A0A5N4B690"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025476">
        <property type="entry name" value="Helitron_helicase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786:SF74">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786">
        <property type="entry name" value="DNA BINDING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14214">
        <property type="entry name" value="Helitron_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helitron helicase-like" evidence="1">
        <location>
            <begin position="256"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0805063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="552" mass="63016" checksum="413898F333AA18A2" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B728</accession>
    <name>A0A5N4B728_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DDE-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_02377</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0805407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B728"/>
    <dbReference type="InParanoid" id="A0A5N4B728"/>
    <dbReference type="OrthoDB" id="6764239at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF74">
        <property type="entry name" value="POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE-1" evidence="2">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0805407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="416" mass="47050" checksum="0A75494B404FBBB2" modified="2020-02-26" version="1">MVCANAKGDLLPPMVVYKRQNVYKNWTMGGPIGTEYSCSKSGWFDMNLFEDWFFSILLPHIQVNSDLETKKIVIGDNLASHFSPRVIEAAIENNIYMAPLPAHSTHIMQPLDVSFFGPMKKKWRTILDTWRKQSRRRGTIPKEHFPSLLKTLWSSIELTAEKNIKSGFKTTGIHPYNPNEVLSKLPSELSSCGSERRLDESLLEFLKNTRGYNKSSTTRRRGKKISVRPGQQMLQQTVEQQSCLPENLNDIQASNVIPDASSSGTPKAPNDNNENEPLSSIAEKCKKVRTKKKNIKSSGLVTPSTSKSKQSDYDYATSNHCSVCNCQYSTYTDPRDWICCISCIKWVCGICNQGSKETEYECPECNLCSICKCDFSVYVGKQDWIRCITCNRWVCGACNKGSKNPRYECPACEDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-06-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B752</accession>
    <name>A0A5N4B752_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_02358</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0805388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B752"/>
    <dbReference type="InParanoid" id="A0A5N4B752"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0805388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="145" mass="16989" checksum="8206C170128D0901" modified="2020-02-26" version="1">METDLGVLAVTILNGMAMVKLKSKRKRSRKCWVKGWVDRRGERGIMQLVNKELSFEDPEAFRNYIRMSKESFMKFLQKLEPQIAKINTNMRESESYRNLMYSTRIHESTISLFIPEVCKAIYLMLKDEYLQVSSTSNRGLGKHSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B7S5</accession>
    <name>A0A5N4B7S5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">small monomeric GTPase</fullName>
            <ecNumber evidence="2">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_02641</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Ras family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="2"/>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0805671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B7S5"/>
    <dbReference type="InParanoid" id="A0A5N4B7S5"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051065">
        <property type="entry name" value="Ras-related_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45704">
        <property type="entry name" value="RAS-LIKE FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0805671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="158" mass="18081" checksum="7EB9B2EE2B50C2D3" modified="2020-02-26" version="1">MKCIYFLLMIYKKDGCLYEHIRWGEAFVIVYSVNDRHSFREARELLGQLSKLKLPSYYTSLLLGNKRDLDHCRQICVDDGHELSLQYGCQFYEVSAAENFAGVSLAFQSLLREAKSVQLLKSLPIRRKLGVNSVSKVLGNIFGKNSKGDRKKRPSLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B7Y0</accession>
    <name>A0A5N4B7Y0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">CRIB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PPYR_02440</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CDC42SE/SPEC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0805470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B7Y0"/>
    <dbReference type="FunCoup" id="A0A5N4B7Y0">
        <property type="interactions" value="916"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4B7Y0"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035023">
        <property type="term" value="P:regulation of Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.810.10:FF:000004">
        <property type="entry name" value="CDC42 small effector protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.810.10">
        <property type="entry name" value="CRIB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036936">
        <property type="entry name" value="CRIB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039056">
        <property type="entry name" value="SPEC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13502">
        <property type="entry name" value="CDC42 SMALL EFFECTOR PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13502:SF6">
        <property type="entry name" value="CDC42 SMALL EFFECTOR PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00786">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0564">Palmitate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRIB" evidence="11">
        <location>
            <begin position="32"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAB0805470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="78" mass="8999" checksum="3B509616D41947F0" modified="2020-02-26" version="1">MTAVGELWVSWFSCCISQPQKRHRHRIDRSMIGNPMNFQHTAHIGSRDIEMPNDQLTALQMQMRSKGGYENSYKVSCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>H1AD96</accession>
    <name>H1AD96_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Luciferin 4-monooxygenase</fullName>
            <ecNumber evidence="4">1.13.12.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">PpyLuc1</name>
        <name evidence="18" type="synonym">LUC1</name>
        <name evidence="21" type="ORF">PPYR_00001</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2012" name="Comp. Biochem. Physiol. B, Biochem. Mol. Biol." volume="161" first="110" last="116">
            <title>Firefly luciferase genes from the subfamilies Psilocladinae and Ototretinae (Lampyridae, Coleoptera).</title>
            <authorList>
                <person name="Oba Y."/>
                <person name="Yoshida M."/>
                <person name="Shintani T."/>
                <person name="Furuhashi M."/>
                <person name="Inouye S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="journal article" date="2018" name="BMC Evol. Biol." volume="18" first="129" last="129">
            <title>Molecular variation across populations of a widespread North American firefly, Photinus pyralis, reveals that coding changes do not underlie flash color variation or associated visual sensitivity.</title>
            <authorList>
                <person name="Lower S.E."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
            </authorList>
            <dbReference type="PubMed" id="30170542"/>
            <dbReference type="DOI" id="10.1186/s12862-018-1251-9"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <tissue evidence="18">Thorax</tissue>
        </source>
    </reference>
    <reference evidence="21 22" key="4">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">1611_PpyrPB1</strain>
            <tissue evidence="21">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="21" key="5">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">1611_PpyrPB1</strain>
            <tissue evidence="21">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>firefly D-luciferin + ATP + O2 = firefly oxyluciferin + hnu + AMP + CO2 + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:10732"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16792"/>
            <dbReference type="ChEBI" id="CHEBI:30212"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58038"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="1.13.12.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EC" id="1.13.12.7" evidence="4"/>
    <dbReference type="EMBL" id="MH759028">
        <property type="protein sequence ID" value="AXY64273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AB644228">
        <property type="protein sequence ID" value="BAL46512.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01002375">
        <property type="protein sequence ID" value="JAV97291.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1AD96"/>
    <dbReference type="SASBDB" id="H1AD96"/>
    <dbReference type="SMR" id="H1AD96"/>
    <dbReference type="FunCoup" id="H1AD96">
        <property type="interactions" value="312"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10253869at2759"/>
    <dbReference type="BioCyc" id="MetaCyc:MONOMER-16917"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047077">
        <property type="term" value="F:Photinus-luciferin 4-monooxygenase (ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008218">
        <property type="term" value="P:bioluminescence"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17642">
        <property type="entry name" value="Firefly_Luc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000007">
        <property type="entry name" value="4-coumarate--CoA ligase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000003">
        <property type="entry name" value="Long-chain-fatty-acid--CoA ligase FadD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.38.10:FF:000005">
        <property type="entry name" value="Luciferin 4-monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.980:FF:000020">
        <property type="entry name" value="Luciferin 4-monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.38.10">
        <property type="entry name" value="Luciferase, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF423">
        <property type="entry name" value="GM05240P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0455">Luminescence</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 21" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="14" id="KW-0599">Photoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="16">
        <location>
            <begin position="37"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="17">
        <location>
            <begin position="453"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="AXY64273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="BAL46512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="JAV97291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAB0804140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="550" mass="60745" checksum="E380FCE9D56ACCDE" modified="2012-03-21" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1JXG6</accession>
    <name>A0A1Y1JXG6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Bacterial surface antigen (D15) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PPYR_02980</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAM50/omp85 family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01102922">
        <property type="protein sequence ID" value="JAV51716.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1JXG6"/>
    <dbReference type="FunCoup" id="A0A1Y1JXG6">
        <property type="interactions" value="1659"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1JXG6"/>
    <dbReference type="OrthoDB" id="1724197at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033108">
        <property type="term" value="P:mitochondrial respiratory chain complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.50:FF:000002">
        <property type="entry name" value="sorting and assembly machinery component 50 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.50">
        <property type="entry name" value="membrane protein fhac: a member of the omp85/tpsb transporter family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000184">
        <property type="entry name" value="Bac_surfAg_D15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039910">
        <property type="entry name" value="D15-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12815:SF18">
        <property type="entry name" value="SORTING AND ASSEMBLY MACHINERY COMPONENT 50 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12815">
        <property type="entry name" value="SORTING AND ASSEMBLY MACHINERY SAMM50 PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01103">
        <property type="entry name" value="Omp85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1134">Transmembrane beta strand</keyword>
    <feature type="domain" description="Bacterial surface antigen (D15)" evidence="8">
        <location>
            <begin position="144"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="JAV51716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0791180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="461" mass="50870" checksum="54662CABEB193300" modified="2017-08-30" version="1">MGIVYAKDKSHGIQAPKINYDDCDSVETREINLEGVRARVDRIHINGLARTKNDYVEGAVQDLFQAVDFQDVLLKAHTVRNKLNSLGCFQNIGVFIDTSKGAKATPEGLEVTFYVRELKRVIGGINTQVGENEGSLVIGLRAPNMFGRGERVQTEFSYGSKNTNNFNVSFIKPFTGKRSPVFSSSIYQATSEWPSSGYKQVDLGLILDFGLHSWPLIKHNFQWDVAIRDLSVLTKGSSFAIREESGVSLKSALRHILSVDVRDDNIFPSCGSLFKYTTEFAGAGGDVGFVKNDVFLQTNYSLFSDCVVQASANAGILNSLGNDWRLGLMDMYYLGGPLSLRGFRMRGVGPHSEGDALGSTWFWGSGLHLFTPLPFRPGKGGFGELFRTHLFVNAGNIGNFEGEEAFVEKVKTNIRVAYGIGLAMRLGQMARIEINYCFPHSFQETDLSQPGVQFGIGVQFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1JYD9</accession>
    <name>A0A1Y1JYD9_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_07191</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01100724">
        <property type="protein sequence ID" value="JAV52810.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1JYD9"/>
    <dbReference type="InParanoid" id="A0A1Y1JYD9"/>
    <dbReference type="OrthoDB" id="8194670at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23992">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.20">
        <property type="entry name" value="Pheromone/general odorant binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006170">
        <property type="entry name" value="PBP/GOBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036728">
        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01395">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036029731" evidence="1">
        <location>
            <begin position="17"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="JAV52810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0799311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="150" mass="17176" checksum="7DBB6CD689DE6660" modified="2017-08-30" version="1">MKIIIYLAFVLAAVTCNETNEQSLDKDKEECIVELSLERDEMAKLDKLDLPPDSNTDFNKLVECISKKKGLMAPNGEIIFPELKELYLEVSKVKNLSKIVQYSYEIFISQILSRCEKQIIDDAEPGKNMILVQRCISNEFENVKRLLPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1K7Y6</accession>
    <name>A0A1Y1K7Y6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histone deacetylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_05246</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>N(6)-acetyl-L-lysyl-[histone] + H2O = L-lysyl-[histone] + acetate</text>
            <dbReference type="Rhea" id="RHEA:58196"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="3.5.1.98"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="GEZM01089328">
        <property type="protein sequence ID" value="JAV57549.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01089326">
        <property type="protein sequence ID" value="JAV57550.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000003">
        <property type="protein sequence ID" value="KAB0800892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1K7Y6"/>
    <dbReference type="FunCoup" id="A0A1Y1K7Y6">
        <property type="interactions" value="1221"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1K7Y6"/>
    <dbReference type="OrthoDB" id="424012at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF38">
        <property type="entry name" value="HISTONE DEACETYLASE 6, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="3">
        <location>
            <begin position="102"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="Histone deacetylase" evidence="3">
        <location>
            <begin position="516"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="849"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="849"/>
            <end position="860"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00048287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="JAV57549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0800892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="871" mass="98323" checksum="F13E1D6ED80ACD3A" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1K8R6</accession>
    <name>A0A1Y1K8R6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pleiotropic regulator 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_04095</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in pre-mRNA splicing as component of the spliceosome. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Identified in the spliceosome C complex. Component of the PRP19-CDC5L splicing complex composed of a core complex comprising a homotetramer of PRPF19, CDC5L, PLRG1 and BCAS2, and at least three less stably associated proteins CTNNBL1, CWC15 and HSPA8. Interacts (via its WD40 repeat domain) directly with CDC5L (via its C-terminal); the interaction is required for mRNA splicing but not for spliceosome assembly. Component of the minor spliceosome, which splices U12-type introns. Within this complex, interacts with CRIPT. Also interacts directly in the complex with BCAS2 and PRPF19. Interacts with USB1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat PRL1/PRL2 family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01088993">
        <property type="protein sequence ID" value="JAV57776.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01088992">
        <property type="protein sequence ID" value="JAV57778.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01088991">
        <property type="protein sequence ID" value="JAV57779.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01088990">
        <property type="protein sequence ID" value="JAV57781.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01088989">
        <property type="protein sequence ID" value="JAV57784.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01088988">
        <property type="protein sequence ID" value="JAV57785.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01088985">
        <property type="protein sequence ID" value="JAV57787.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01088984">
        <property type="protein sequence ID" value="JAV57790.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01088983">
        <property type="protein sequence ID" value="JAV57792.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01088979">
        <property type="protein sequence ID" value="JAV57793.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
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        <property type="protein sequence ID" value="KAB0801909.1"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR19923">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
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    </dbReference>
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        <property type="match status" value="7"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
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        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="144"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="186"/>
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        </location>
    </feature>
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        <location>
            <begin position="228"/>
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        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="270"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="353"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00046238"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00062641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00073631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="JAV57793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0801909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="458" mass="51286" checksum="CC5BFE6B2D64F97C" modified="2017-08-30" version="1">MHDEVQRHSVHTLVFRSLKRSHDMFLANQGLLPTVDDVAENVRKGIKARDNYGLVFDDVKKMQAMKQLQIIENGPNPPPPGTAFPTETDNLVANTSAVVPFSENSLIQRNISSSQPNQLNNLMRKAPSMPKPKWHAPWKLYRVIAGHLGWVRCVTVEPGNEWFATGSADRIIKIWDLATGQLKVSLTGHVSTVRGLAVSSRHPYLFSCGEDRQVKCWDLEYNKVIRHYHGHLSAVYTLALHPTIDVLVTAGRDSTARIWDMRTKANVHTFQGHTHTVASVICQASEPQIITGSHDTTIRLWDLAAGKSVCSLTNHKKSVRSLIFHPTLNMFASGSPDNIKQWKCPDGKFIQNLSGHNAIVNCLAVNPEGALVSGGDNGTLFFWDWRTGYNFQRLQAPVQPGSMDSEAGIFSMIFDHSGSRLITTEADKTIKIYKEDETASEESHPINWKPDILKRRKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1KDE6</accession>
    <name>A0A1Y1KDE6_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PPYR_09678</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TO family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01091748">
        <property type="protein sequence ID" value="JAV56777.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="InParanoid" id="A0A1Y1KDE6"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007623">
        <property type="term" value="P:circadian rhythm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.15.10.30:FF:000001">
        <property type="entry name" value="Takeout-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.30">
        <property type="entry name" value="Haemolymph juvenile hormone binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010562">
        <property type="entry name" value="Haemolymph_juvenile_hormone-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038606">
        <property type="entry name" value="To_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008:SF39">
        <property type="entry name" value="CIRCADIAN CLOCK-CONTROLLED PROTEIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008">
        <property type="entry name" value="PROTEIN TAKEOUT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06585">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0090">Biological rhythms</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036029762" evidence="4">
        <location>
            <begin position="18"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00060902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="JAV56777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0798685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="243" mass="27062" checksum="F7770FCAC3591E01" modified="2017-08-30" version="1">MSTRGVIYFVLFVAVNCKIPDYINVCSQNDKDLASCITNSINSLKPRLLSGIPELGVPALEPLELDTLRILGQSSLSTNLSDVKAWGVSEFKILKLTPKITKNSRHFKFEVHIPKLHVRGNYVINTRLAFIDLKGSGPFNANITNPHFECVLLGKKVQINGENHLKFVDVQCVIKSVDNSKIYFENLFNGDPVIGKAVNDAIDDNSEALFTEARPNIVEAVTKKLLEVANQITQSFTFEELFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1KFF2</accession>
    <name>A0A1Y1KFF2_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SCP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PPYR_06093</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GEZM01089435">
        <property type="protein sequence ID" value="JAV57497.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000004">
        <property type="protein sequence ID" value="KAB0800353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1KFF2"/>
    <dbReference type="FunCoup" id="A0A1Y1KFF2">
        <property type="interactions" value="23"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1KFF2"/>
    <dbReference type="OrthoDB" id="337038at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd05382">
        <property type="entry name" value="CAP_GAPR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.33.10:FF:000010">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018244">
        <property type="entry name" value="Allrgn_V5/Tpx1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034113">
        <property type="entry name" value="SCP_GAPR1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS01010">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033289601" description="SCP domain-containing protein" evidence="3">
        <location>
            <begin position="18"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="4">
        <location>
            <begin position="22"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="JAV57497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0800353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="168" mass="19019" checksum="AF69842503B1E2EF" modified="2017-08-30" version="1">MRVGVELLCFIGASVLAVLGNDQINTAVLTLHNQYRAKHGVPALVLDSEMNRYAQEWANQLAKTSTFSHRPNNKYGENLYWGSYPGETDLQISQRGVKAWYDENKFYNYDSETVQTKALHFTQVIWRSSRRLGIGVARGNNGVYLVCNYDPRGNFVGQFRANVPRPTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1KK46</accession>
    <name>A0A1Y1KK46_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DNA mismatch repair protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PPYR_03418</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the post-replicative DNA mismatch repair system (MMR).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
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        <property type="protein sequence ID" value="JAV60974.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01083845">
        <property type="protein sequence ID" value="JAV60981.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01083842">
        <property type="protein sequence ID" value="JAV60988.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1KK46"/>
    <dbReference type="FunCoup" id="A0A1Y1KK46">
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    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1KK46"/>
    <dbReference type="OrthoDB" id="121051at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032301">
        <property type="term" value="C:MutSalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1170.10:FF:000002">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017261">
        <property type="entry name" value="DNA_mismatch_repair_MutS/MSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007861">
        <property type="entry name" value="DNA_mismatch_repair_MutS_clamp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF148">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MSH6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05190">
        <property type="entry name" value="MutS_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037677">
        <property type="entry name" value="DNA_mis_repair_Msh6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55271">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53150">
        <property type="entry name" value="DNA repair protein MutS, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein MutS core" evidence="8">
        <location>
            <begin position="482"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="9">
        <location>
            <begin position="835"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="JAV60988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0791618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1060" mass="120988" checksum="8A6F8D1FF6AA9459" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1KV68</accession>
    <name>A0A1Y1KV68_PHOPY</name>
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        <recommendedName>
            <fullName evidence="4">histone acetyltransferase</fullName>
            <ecNumber evidence="4">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">PPYR_04446</name>
        <name evidence="20" type="ORF">PPYR_08855</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="20 22" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">1611_PpyrPB1</strain>
            <tissue evidence="20">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">1611_PpyrPB1</strain>
            <tissue evidence="20">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-lysyl-[histone] + acetyl-CoA = N(6)-acetyl-L-lysyl-[histone] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21992"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:21993"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase family. GCN5 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="4"/>
    <dbReference type="EMBL" id="GEZM01073203">
        <property type="protein sequence ID" value="JAV65282.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1KV68"/>
    <dbReference type="FunCoup" id="A0A1Y1KV68">
        <property type="interactions" value="453"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1KV68"/>
    <dbReference type="OrthoDB" id="1937912at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140672">
        <property type="term" value="C:ATAC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043992">
        <property type="term" value="F:histone H3K9 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05509">
        <property type="entry name" value="Bromo_gcn5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000004">
        <property type="entry name" value="Histone acetyltransferase KAT2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037800">
        <property type="entry name" value="GCN5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009464">
        <property type="entry name" value="PCAF_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45750">
        <property type="entry name" value="GH11602P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45750:SF3">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06466">
        <property type="entry name" value="PCAF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0010">Activator</keyword>
    <keyword evidence="13" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8 15" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="18">
        <location>
            <begin position="452"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="17">
        <location>
            <begin position="692"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="8"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="JAV65282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAB0797862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAB0802260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="784" mass="91026" checksum="5AD05087ED77EC4E" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1KVJ7</accession>
    <name>A0A1Y1KVJ7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DNA repair nuclease/redox regulator APEX1</fullName>
            <shortName evidence="14">APEN</shortName>
            <shortName evidence="14">REF-1</shortName>
            <ecNumber evidence="14">3.1.11.2</ecNumber>
            <ecNumber evidence="14">3.1.21.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">APEX nuclease</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Apurinic-apyrimidinic endonuclease 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Redox factor-1</fullName>
        </alternativeName>
        <component>
            <recommendedName>
                <fullName evidence="14">DNA repair nuclease/redox regulator APEX1, mitochondrial</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PPYR_05335</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">1611_PpyrPB1</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">1611_PpyrPB1</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.</text>
            <dbReference type="EC" id="3.1.11.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12 14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="12 14">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="12 14">Probably binds two magnesium or manganese ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the DNA repair enzymes AP/ExoA family.</text>
    </comment>
    <dbReference type="EC" id="3.1.11.2" evidence="14"/>
    <dbReference type="EC" id="3.1.21.-" evidence="14"/>
    <dbReference type="EMBL" id="GEZM01074319">
        <property type="protein sequence ID" value="JAV64598.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000003">
        <property type="protein sequence ID" value="KAB0800981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1KVJ7"/>
    <dbReference type="InParanoid" id="A0A1Y1KVJ7"/>
    <dbReference type="OrthoDB" id="498125at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008311">
        <property type="term" value="F:double-stranded DNA 3'-5' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09087">
        <property type="entry name" value="Ape1-like_AP-endo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000009">
        <property type="entry name" value="DNA-(apurinic or apyrimidinic site) lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004808">
        <property type="entry name" value="AP_endonuc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020847">
        <property type="entry name" value="AP_endonuclease_F1_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020848">
        <property type="entry name" value="AP_endonuclease_F1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00195">
        <property type="entry name" value="exoDNase_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00633">
        <property type="entry name" value="xth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748">
        <property type="entry name" value="AP ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748:SF6">
        <property type="entry name" value="DNA-(APURINIC OR APYRIMIDINIC SITE) ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00726">
        <property type="entry name" value="AP_NUCLEASE_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00727">
        <property type="entry name" value="AP_NUCLEASE_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51435">
        <property type="entry name" value="AP_NUCLEASE_F1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 12 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0464">Manganese</keyword>
    <keyword evidence="5 12 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="16">
        <location>
            <begin position="98"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="32"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="11">
        <location>
            <position position="239"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="337"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="337"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="13">
        <location>
            <position position="241"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="13">
        <location>
            <position position="311"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA substrate" evidence="13">
        <location>
            <position position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="JAV64598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAB0800981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="346" mass="39879" checksum="D0CAC7F0620BACB0" modified="2017-08-30" version="1">MQVLRNFFVNNKSLTLVTKKLIISLEQRRISAMPPKKRKAASDEEGGSEKAKSQKTKKEKPAAKKKEKTCPTDYEAIDYSCTTKNKHGETFNVRISNWNVDGLRAWVQKDGLSFLEYEKPDILCLQETKCSEDKLPDDIKELQDYKMFWHNSNKEGYAGVALFSLVEPLSIKYGIGNDEHDTEGRCITAEYEKYYVVSVYVPNAGRRLVTLPKRLEWNKIFKKFIKELDKQKPVIICGDMNVAHSEIDLANPKTNTKNAGFTKEEREGMTDFLSDGYVDTFRKLYPDQTGAYTFWTYMRNARSNNVGWRLDYFIVSDRLVDNVCDNKIRSGVFGSDHCPITLFMNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1KZW7</accession>
    <name>A0A1Y1KZW7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA sliding clamp PCNA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PPYR_02474</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processivity during elongation of the leading strand.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the PCNA family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01068543">
        <property type="protein sequence ID" value="JAV66904.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0805504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1KZW7"/>
    <dbReference type="FunCoup" id="A0A1Y1KZW7">
        <property type="interactions" value="2043"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1KZW7"/>
    <dbReference type="OrthoDB" id="534348at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043626">
        <property type="term" value="C:PCNA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030337">
        <property type="term" value="F:DNA polymerase processivity factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006275">
        <property type="term" value="P:regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042542">
        <property type="term" value="P:response to hydrogen peroxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072702">
        <property type="term" value="P:response to methyl methanesulfonate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019985">
        <property type="term" value="P:translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00577">
        <property type="entry name" value="PCNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.70.10.10:FF:000001">
        <property type="entry name" value="Proliferating cell nuclear antigen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.70.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00317">
        <property type="entry name" value="DNApol_clamp_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046938">
        <property type="entry name" value="DNA_clamp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000730">
        <property type="entry name" value="Pr_cel_nuc_antig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022649">
        <property type="entry name" value="Pr_cel_nuc_antig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022659">
        <property type="entry name" value="Pr_cel_nuc_antig_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022648">
        <property type="entry name" value="Pr_cel_nuc_antig_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010916">
        <property type="entry name" value="TonB_box_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00590">
        <property type="entry name" value="pcna"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11352">
        <property type="entry name" value="PROLIFERATING CELL NUCLEAR ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11352:SF0">
        <property type="entry name" value="PROLIFERATING CELL NUCLEAR ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02747">
        <property type="entry name" value="PCNA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00705">
        <property type="entry name" value="PCNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00339">
        <property type="entry name" value="PCNACYCLIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55979">
        <property type="entry name" value="DNA clamp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01251">
        <property type="entry name" value="PCNA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00293">
        <property type="entry name" value="PCNA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00430">
        <property type="entry name" value="TONB_DEPENDENT_REC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proliferating cell nuclear antigen PCNA N-terminal" evidence="8">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Proliferating cell nuclear antigen PCNA C-terminal" evidence="9">
        <location>
            <begin position="127"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="JAV66904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0805504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="260" mass="28902" checksum="E83ADE8CD9A2CD11" modified="2017-08-30" version="1">MFEARLVSSGTLKKVLDAIKDLLNEASFDCSDTGIQLQAMDSSHVSLVSLSLRADGFDKYRCDRNLTMGMNLASMTKILKCANNDDTVTVKAQDDADCVTFVFESKKQEKISDYEMKLMNLDQEHLGIPETDFSCVIHMPSGEFSRICRDLSQFGESVIISCTKEGVRFSSSGDIGSANIKLAQTNNIDKEEETVSIDLQEPVTLTFACQYLNSFTKATPLSNRVSLSMSANVPLVVEYEIPDLGHIRYYLAPKIEEDEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1L4R4</accession>
    <name>A0A1Y1L4R4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2 5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_05917</name>
        <name evidence="10" type="ORF">PPYR_05918</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2 5"/>
    <dbReference type="EMBL" id="GEZM01065037">
        <property type="protein sequence ID" value="JAV68584.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000004">
        <property type="protein sequence ID" value="KAB0800177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000004">
        <property type="protein sequence ID" value="KAB0800178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1L4R4"/>
    <dbReference type="FunCoup" id="A0A1Y1L4R4">
        <property type="interactions" value="684"/>
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    <dbReference type="InParanoid" id="A0A1Y1L4R4"/>
    <dbReference type="OrthoDB" id="77911at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="FKBP2/11"/>
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    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45779">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
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        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
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        <property type="entry name" value="FKBP_PPIASE"/>
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        <location>
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            <end position="28"/>
        </location>
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    <feature type="chain" id="PRO_5033289701" description="peptidylprolyl isomerase" evidence="6">
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            <begin position="29"/>
            <end position="147"/>
        </location>
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        <location>
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            <end position="142"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="JAV68584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0800177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0800178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="147" mass="16164" checksum="E011C464B870575F" modified="2017-08-30" version="1">MKFGIPLSCPLLILAVLVLFAIISETNGKDQPKFKLKIGIKKRVENCVSKSKKGDLLHVHYKGNLENGDEFDSSYTRGQPLTFTLGSGQVIKGWDQGLVGMCVGEQRKLVIPSELGYGKKGAPPKIPADATLTFHVELVKIEQRDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1L596</accession>
    <name>A0A1Y1L596_PHOPY</name>
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        <recommendedName>
            <fullName evidence="24">Histone-lysine N-methyltransferase eggless</fullName>
        </recommendedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="21">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
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                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
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            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="22 23" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">1611_PpyrPB1</strain>
            <tissue evidence="22">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">1611_PpyrPB1</strain>
            <tissue evidence="22">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Transcribed_RNA"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Methyl_CpG_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
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        <property type="entry name" value="Pre-SET_dom"/>
    </dbReference>
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        <property type="entry name" value="SET_dom"/>
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        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047232">
        <property type="entry name" value="SETDB1/2-like_MBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051516">
        <property type="entry name" value="SETDB_methyltransferase"/>
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    <dbReference type="InterPro" id="IPR041292">
        <property type="entry name" value="Tudor_4"/>
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    <dbReference type="InterPro" id="IPR041291">
        <property type="entry name" value="TUDOR_5"/>
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    <dbReference type="PANTHER" id="PTHR46024">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE EGGLESS"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
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    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
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    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
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    <keyword evidence="12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MBD" evidence="20">
        <location>
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            <end position="801"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-SET" evidence="18">
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        </location>
    </feature>
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        <location>
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            <end position="1184"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="19">
        <location>
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            <end position="1209"/>
        </location>
    </feature>
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            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
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            <end position="390"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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            <end position="1110"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
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            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
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            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="323"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="367"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="1002"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1017"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
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            <end position="1073"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
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            <end position="1089"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="JAV68859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAB0791507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="24">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1209" mass="137968" checksum="8BCB87FDF3D3600A" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LC56</accession>
    <name>A0A1Y1LC56_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_11277</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01064858">
        <property type="protein sequence ID" value="JAV68627.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0794438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1LC56"/>
    <dbReference type="InParanoid" id="A0A1Y1LC56"/>
    <dbReference type="OrthoDB" id="190201at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
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        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF14">
        <property type="entry name" value="SERINE HYDROLASE-LIKE PROTEIN DDB_G0286239"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="41"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="JAV68627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0794438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="316" mass="36676" checksum="9C02A540CCE49C07" modified="2017-08-30" version="1">MLLRGIRGHSKWKQMWEEIKIPVPWGHIAGKWWGPQDKRPILVLHGWQDNCGSFDRLIPLLKPELGYLAIDFPGHGLSSKLPLGVSYYWSDYIVFLRRVVQYFNWPKVSLLAHSISGSIAYNYATLYPKTVDFLIAIEGLRPLTDDLKITELGVNMDRFIKYDHLLSLDQEGPSYLYNELEKRLHADSDNSISLETCKYVLERTIAKSKTKPNEFYFTRDLRLKLLPFLEYKTGDVMKMTDKFTFPTLLCLGTVVTEKFALLTQTPEFFDVLKKINPKFEIHTIEGTHHVHLNNPEPVAGLINPFIERYDVEDRSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LGS0</accession>
    <name>A0A1Y1LGS0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Receptor expression-enhancing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PPYR_00623</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the DP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01057952">
        <property type="protein sequence ID" value="JAV72071.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01057951">
        <property type="protein sequence ID" value="JAV72074.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1LGS0"/>
    <dbReference type="FunCoup" id="A0A1Y1LGS0">
        <property type="interactions" value="658"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1LGS0"/>
    <dbReference type="OrthoDB" id="10009287at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004345">
        <property type="entry name" value="TB2_DP1_HVA22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300">
        <property type="entry name" value="HVA22-LIKE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300:SF161">
        <property type="entry name" value="RECEPTOR EXPRESSION-ENHANCING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03134">
        <property type="entry name" value="TB2_DP1_HVA22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="JAV72071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0803653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="175" mass="20326" checksum="50C3C2B26CBEC1BA" modified="2017-08-30" version="1">MAAKVMEIKEKLEATLNDGSKPWTAILAQIEAKTGINRVYIFFVSVAGLALWLMFGFAGQLVCNCVGFLYPAYVSIHAIETPHKDDDTKWLTYWVVYALFSLVEFFADIIVGWFPMYWLLKCVFMVWLMIPTEFNGSLILYNRIIKPYYLQHHSRVDDTINKVRQEATKILEKQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LKH0</accession>
    <name>A0A1Y1LKH0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PPYR_11262</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
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                <person name="Bessho-Uehara M."/>
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                <person name="Debat H.J."/>
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    </dbReference>
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    <keyword evidence="5 8" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
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        </location>
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        <location>
            <begin position="20"/>
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            <begin position="123"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00032923"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF20145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="JAV72757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAB0791693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="168" mass="19159" checksum="CC7753D8B180F0EA" modified="2017-08-30" version="1">MEFVTPILLALATISTVYSLKPGDCEVCIKAIDKFSSKLSDDVKKDPKKIETAFKEFCKGTKTKENRFCYYLGGLEESATGILSELSKPLSWSMPSDKICEKLKKKDGQICELRYDVEIDLKTVDLKKLKVRDLKKIINDWGEDCQGCIEKNDFIQKIEQLKPIHSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LSV1</accession>
    <name>A0A1Y1LSV1_PHOPY</name>
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        <recommendedName>
            <fullName evidence="11">Transmembrane protein 53</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_03227</name>
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    <organism evidence="8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
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        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus outer membrane</location>
            <topology evidence="6">Single-pass membrane protein</topology>
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    <comment type="similarity">
        <text evidence="1">Belongs to the TMEM53 family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
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        <property type="entry name" value="DUF829_TMEM53"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12265">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 53"/>
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    </dbReference>
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        <property type="entry name" value="TRANSMEMBRANE PROTEIN 53"/>
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    </dbReference>
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        <property type="entry name" value="alpha/beta-Hydrolases"/>
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    </dbReference>
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    </evidence>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00034303"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="JAV76729.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAB0791427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="269" mass="31332" checksum="AEA2BE6110D7E431" modified="2017-08-30" version="1">MAEEQDTLEYYIRFPSPSQQSANFSQEKTPIVILFGWAGCQDRYLRKYSQLYEEWGLITLRYCAPVKFILWKRNELRKIGERIVKLLVDMNFESHPVVVHCFSNGGAFLYHNFVLALRHAPKPIKVKGVIFDSGPGPRRFVSLYRAISAIISGNVIYNFVIAALLTSFLIVVWECEILKSYFVNDDYQSDPIEYLKIEDNKCPQYFIYSKADKLIFYEDVENFINIRRNNGVDVSVLTFDDSPHVKHYAHYKNEYSEGVNNFLVGCLKN</sequence>
</entry>
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    <accession>A0A1Y1MBW2</accession>
    <name>A0A1Y1MBW2_PHOPY</name>
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        <recommendedName>
            <fullName evidence="2">Protein DPCD</fullName>
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        <name evidence="4" type="ORF">PPYR_15235</name>
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    <organism evidence="3">
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
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            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
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            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
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            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DPCD family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01037460">
        <property type="protein sequence ID" value="JAV82060.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01001379">
        <property type="protein sequence ID" value="KAB0790403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="10256139at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
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    </dbReference>
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        <property type="entry name" value="DPCD"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31921:SF1">
        <property type="entry name" value="PROTEIN DPCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14913">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02065">
        <property type="entry name" value="PROTEINDPCD"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="JAV82060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0790403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="199" mass="23466" checksum="AF46165D96C5138D" modified="2017-08-30" version="1">MIDWLTILKNAKKTCIQQGNLRKVHFLLPDGREMVEEYNMETGVVTRRAWKVKTNVGGEGEWHIEVGDPEPTFKTEDILIKENSSQPFVSRRITRKNLEWRIRNLPYSIDVYSVTVDPESRHLIVRTSNRKYFKILNIPELERLNLLAEQNRIQMFHKFNTLVINYEKPKQLIDFEKALFDEVKTIKACKEGDMDCKPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1MC39</accession>
    <name>A0A1Y1MC39_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SCP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PPYR_06377</name>
    </gene>
    <organism evidence="5">
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
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            <dbReference type="DOI" id="10.1038/srep38556"/>
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                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
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        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
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                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
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        </source>
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                <person name="Schmitz R.J."/>
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                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
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                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
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                <person name="Debat H.J."/>
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                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
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                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
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    <reference evidence="16" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">1611_PpyrPB1</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Microsome membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01026153">
        <property type="protein sequence ID" value="JAV87205.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000003">
        <property type="protein sequence ID" value="KAB0801349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1MRQ2"/>
    <dbReference type="InParanoid" id="A0A1Y1MRQ2"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11056">
        <property type="entry name" value="CYP6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000042">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050476">
        <property type="entry name" value="Insect_CytP450_Detox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292:SF84">
        <property type="entry name" value="CYTOCHROME P450 28A5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 14" id="KW-0349">Heme</keyword>
    <keyword evidence="11 14" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0492">Microsome</keyword>
    <keyword evidence="12" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="14">
        <location>
            <position position="444"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="JAV87205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAB0801349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="502" mass="57155" checksum="5ED7AEC60EE2BAE1" modified="2017-08-30" version="1">MFLLFLFGAIIALYFYLSSGFQYWKKRNVPNPEPSLLFGNLGDSLTSKRSVGQIYTDIYRDFPDVLYVGFYRGRQPGLVLRDPQLIRDVMNKDFNSFHDNDLIISEEVDPLGGRNTFSLKGEKWKTAKSLITPCFTAKKMREMHVFLQKAANRMVRYLDDDVLKGGGSLEVRELFAQFGTEVVANCAFGLEGRTFDEPDPLFRKMGKKLFEPSPLTVIKFSIMFMFPSLSNILKIRFIPKDVTEYFCNIVDATLNYRKENNIVRNDFLDSMLELKNKLGESKFTNTDVTAQAVGFFTDGFETSSCVIAFALYELAANPEILNRLRAEVDQALLMQKELDYDSVHGLKYLDAVICETVRLHPPALVLLRSCTKPFVFPPPRGQGTGKDVNVEVDTPIMIPLYGLHTDPKYFKDPYVFDPERFMGENKESIVRGAYLPFGDGPRACHGQRFGATQAKVALINILANFDVTVNERTKTPLEIDPRYLILHVKGGLWINFSRRTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1MTQ1</accession>
    <name>A0A1Y1MTQ1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Sphingomyelin phosphodiesterase</fullName>
            <ecNumber evidence="12">3.1.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PPYR_06989</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">1611_PpyrPB1</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">1611_PpyrPB1</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Converts sphingomyelin to ceramide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a sphingomyelin + H2O = phosphocholine + an N-acylsphing-4-enine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19253"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17636"/>
            <dbReference type="ChEBI" id="CHEBI:52639"/>
            <dbReference type="ChEBI" id="CHEBI:295975"/>
            <dbReference type="EC" id="3.1.4.12"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:19254"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the acid sphingomyelinase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.12" evidence="12"/>
    <dbReference type="EMBL" id="GEZM01021489">
        <property type="protein sequence ID" value="JAV88981.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1MTQ1"/>
    <dbReference type="InParanoid" id="A0A1Y1MTQ1"/>
    <dbReference type="OrthoDB" id="282973at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061750">
        <property type="term" value="F:acid sphingomyelin phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006685">
        <property type="term" value="P:sphingomyelin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00842">
        <property type="entry name" value="MPP_ASMase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041805">
        <property type="entry name" value="ASMase/PPN1_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011001">
        <property type="entry name" value="Saposin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008139">
        <property type="entry name" value="SaposinB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011160">
        <property type="entry name" value="Sphingomy_PDE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340">
        <property type="entry name" value="SPHINGOMYELIN PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340:SF34">
        <property type="entry name" value="SPHINGOMYELIN PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000948">
        <property type="entry name" value="Sphingomy_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47862">
        <property type="entry name" value="Saposin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50015">
        <property type="entry name" value="SAP_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 15" id="KW-0732">Signal</keyword>
    <keyword evidence="7 13" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033289818" description="Sphingomyelin phosphodiesterase" evidence="15">
        <location>
            <begin position="22"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin B-type" evidence="16">
        <location>
            <begin position="41"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="381"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="415"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="417"/>
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        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
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        <location>
            <begin position="45"/>
            <end position="118"/>
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    <feature type="disulfide bond" evidence="14">
        <location>
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    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
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    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="175"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="181"/>
            <end position="204"/>
        </location>
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    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="341"/>
            <end position="389"/>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
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        <source>
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        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047268"/>
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        <source>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="JAV88981.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAB0799109.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
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    </evidence>
    <sequence length="565" mass="65077" checksum="4EB607A04506CD35" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1MVA3</accession>
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        <name evidence="16" type="ORF">PPYR_13505</name>
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        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
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            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
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                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
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            <dbReference type="DOI" id="10.1038/srep38556"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">1611_PpyrPB1</strain>
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    <reference evidence="16" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="16">1611_PpyrPB1</strain>
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        </source>
    </reference>
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        <text evidence="13">Catalyzes the exchange of an acyl for a long-chain alkyl group and the formation of the ether bond in the biosynthesis of ether phospholipids.</text>
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        <reaction evidence="13">
            <text>a long chain fatty alcohol + a 1-acylglycerone 3-phosphate = a 1-O-alkylglycerone 3-phosphate + a long-chain fatty acid + H(+)</text>
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            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17135"/>
            <dbReference type="ChEBI" id="CHEBI:57534"/>
            <dbReference type="ChEBI" id="CHEBI:57560"/>
            <dbReference type="ChEBI" id="CHEBI:73315"/>
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            <name>FAD</name>
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    <comment type="pathway">
        <text evidence="2 13">Glycerolipid metabolism; ether lipid biosynthesis.</text>
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    <comment type="subunit">
        <text evidence="4 13">Homodimer.</text>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Peroxisome</location>
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    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the FAD-binding oxidoreductase/transferase type 4 family.</text>
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        <property type="project" value="UniProtKB-SubCell"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="6 13" id="KW-0285">Flavoprotein</keyword>
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    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="14">
        <location>
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            <end position="328"/>
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    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="520"/>
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    <feature type="binding site" evidence="11">
        <location>
            <begin position="178"/>
            <end position="184"/>
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        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="260"/>
            <end position="263"/>
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        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="312"/>
            <end position="318"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="458"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for enzyme activity" evidence="12">
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            <position position="363"/>
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    </feature>
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        <source>
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        <source>
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        <source>
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    </evidence>
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        <source>
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        <source>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
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        <source>
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    </evidence>
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        <source>
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        <source>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51387"/>
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    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="JAV88460.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAB0793885.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="604" mass="68094" checksum="ACD167A95627ED82" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1N277</accession>
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        <recommendedName>
            <fullName evidence="2">Superoxide dismutase copper/zinc binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="4" type="ORF">PPYR_11811</name>
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    <organism evidence="3">
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
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                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
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                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
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                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
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                <person name="Sander Lower S.E."/>
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    <sequence length="271" mass="30610" checksum="E240819C64E305A9" modified="2017-08-30" version="1">MEYYDICEYKAAQICCYNHTDYLAPMKTALLLFLVYSFGQSSKLPADYKRCDRNDPNFNGCLKDALEHAISRLANGDKSLGIPPLEPIHIPHAVLKEGTGAVHVVQKFTNLNIHKLTKSSITGFSSTLTKTQLSFTLNITAPEYVLEADYDFNGRLLVLPVVGVGKSKVNLYNVNTKLELGGEYVSRNGQQYFDVKSFDVKLAPGKVTYRFENLFNGNQELSNQIHTVLNENWREVFYDVKDGYEELIATVARAYANQLFSKIPVKNIFLK</sequence>
</entry>
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        </lineage>
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    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
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            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
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            <authorList>
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                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
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                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
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            <dbReference type="PubMed" id="30324905"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
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        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
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        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
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        <location>
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    </feature>
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        <location>
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            <end position="58"/>
        </location>
    </feature>
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    </feature>
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            <end position="174"/>
        </location>
    </feature>
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        <location>
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            <end position="233"/>
        </location>
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        <location>
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        </location>
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        </location>
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        </location>
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        <location>
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            <begin position="1"/>
            <end position="399"/>
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        <source>
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    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="JAV93132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0802355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="401" mass="44388" checksum="BE6ECD420E2ACFDC" modified="2017-08-30" version="1">MDRSILKIYIISLIDLLAVGLTFPLLFPHLRTLGASHFVVGVFGATYSGLQVLSGPVIGSWSDIRGRSSVASVVLSISAVCYVLTGLTTSLAVIYILRILLGFLKHTQTLCKALIADIVPKDKQTEVYGRSTAVSSIGFIVGPIVGGHLIELPNGFSYVCTLTSILFVINIVLFRTFDDVICGKVSEKKQFHLTDIKQEFTKAVKELLEMDWKQYWDVFTLRFLYSFCIAIYFSNQSLFISEQYQLSQKYIGYIISFFSIIGGLSSIAIGQIKVKFYNNQNESLTLLLHLFLTMTFCFFGIHLSPNLGFLLVLLTPFAFSSAALRVLTMELILNRSHTNDKGSLSGVANSVMSIGRFISPLISGIIADWCGESKVMLFAFIPSLFATFLCVKLIKTKSKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1NEM3</accession>
    <name>A0A1Y1NEM3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Importin-11</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Ran-binding protein 11</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PPYR_04207</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">1611_PpyrPB1</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">1611_PpyrPB1</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="11">Interacts with UBE2E3 and RPL12.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the importin beta family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01007628">
        <property type="protein sequence ID" value="JAV95035.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01007627">
        <property type="protein sequence ID" value="JAV95036.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1NEM3"/>
    <dbReference type="FunCoup" id="A0A1Y1NEM3">
        <property type="interactions" value="1759"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1NEM3"/>
    <dbReference type="OrthoDB" id="361693at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000116">
        <property type="entry name" value="importin-11 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058669">
        <property type="entry name" value="TPR_IPO7/11-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF7">
        <property type="entry name" value="IMPORTIN-11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25758">
        <property type="entry name" value="TPR_IPO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="14">
        <location>
            <begin position="28"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00062902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00072254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00077811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="JAV95035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAB0802021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="981" mass="113062" checksum="0CC9B3281E5BB03D" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1NF84</accession>
    <name>A0A1Y1NF84_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UDP-glucuronosyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_05749</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:132367"/>
            <dbReference type="ChEBI" id="CHEBI:132368"/>
            <dbReference type="EC" id="2.4.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Membrane</location>
            <topology evidence="5">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.17" evidence="5"/>
    <dbReference type="EMBL" id="GEZM01007246">
        <property type="protein sequence ID" value="JAV95275.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000003">
        <property type="protein sequence ID" value="KAB0801395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1NF84"/>
    <dbReference type="FunCoup" id="A0A1Y1NF84">
        <property type="interactions" value="289"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1NF84"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015020">
        <property type="term" value="F:glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000050">
        <property type="entry name" value="UDP-glucuronosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035595">
        <property type="entry name" value="UDP_glycos_trans_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF159">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00375">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033827435" description="UDP-glucuronosyltransferase" evidence="5">
        <location>
            <begin position="20"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="468"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="JAV95275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0801395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="512" mass="58395" checksum="02812DAF04396CAB" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1NFU6</accession>
    <name>A0A1Y1NFU6_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_10187</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01003441">
        <property type="protein sequence ID" value="JAV96801.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01003439">
        <property type="protein sequence ID" value="JAV96803.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1NFU6"/>
    <dbReference type="InParanoid" id="A0A1Y1NFU6"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="JAV96803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0796126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="168" mass="18857" checksum="B67490FFB909C7E6" modified="2017-08-30" version="1">MATKVPLNDAPPPYSTATAPIGFHLPENPQYTTSSSGNPPYPPVGSTPYPTEQGPMHPFPQPIGITSPSPLNAYPTHAVSAPLMQQQPTIAALNATPRYQSYRGFGWRNRKGGAVISIIVFVIFLIIFLIVFSTIFKKSSEFHKEFEETRQRQEEFRRKHFPESNNNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1NJ28</accession>
    <name>A0A1Y1NJ28_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Actin-related protein 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_07079</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01001382">
        <property type="protein sequence ID" value="JAV97899.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01001381">
        <property type="protein sequence ID" value="JAV97904.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01001380">
        <property type="protein sequence ID" value="JAV97907.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01001379">
        <property type="protein sequence ID" value="JAV97912.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01001378">
        <property type="protein sequence ID" value="JAV97916.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01001377">
        <property type="protein sequence ID" value="JAV97920.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1NJ28"/>
    <dbReference type="FunCoup" id="A0A1Y1NJ28">
        <property type="interactions" value="987"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1NJ28"/>
    <dbReference type="OrthoDB" id="337660at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10207">
        <property type="entry name" value="ASKHA_NBD_Arp10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="JAV97904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0799199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="374" mass="42097" checksum="71A0F4AFED16BA7C" modified="2017-08-30" version="1">MPIYEGIGAITDKLVVVMDIGAAYTKLGFSGEFSPRYIIRSEVRCKETGLMRNIRDYKDDQDLYDLLVDFLHSLYFKYVLISPKDRPVVVVESLLCPTIFRETLAKVLFCHYEVSMILVVPSHLVCLASLGIDTALVLDVGFSEAVAIPVCHGLPVIHAWQALPLASQAVHINLKSMLTANNTGISSLSEWELEDIKVRCCFVTPKDRAMELSKTTPSLTACPDVTYPLQGSKSITVLGKVRETVYETFFQEDNDHQCVSTMLLDAILKVNLDLRLQLAENIVIMGGTAMAPGLKSRLKEELYEQLKKDRYSKLKIKVFKFHSPPCKDNYTSWLGGAIYGCTELLGMKGLTRENYLKENRLPDWANMRDNLRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-06-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N3ZY39</accession>
    <name>A0A5N3ZY39_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_15726</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01002117">
        <property type="protein sequence ID" value="KAB0789980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N3ZY39"/>
    <dbReference type="InParanoid" id="A0A5N3ZY39"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0789980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="105" mass="12430" checksum="9430BFB908983DD3" modified="2020-02-26" version="1">MTEKITTTPNGHKTKRRGLLNLSAANEKHFFLMQIFLQFQRPFVKISIFKLAYETAHYRHRNRHCKTHMCLQVYQRAPQSTSQVMAMIPCDVSKQTFWTDERPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N3ZY93</accession>
    <name>A0A5N3ZY93_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">receptor protein-tyrosine kinase</fullName>
            <ecNumber evidence="2">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">PPYR_15663</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">1611_PpyrPB1</strain>
            <tissue evidence="24">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19 26">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="2"/>
    <dbReference type="EMBL" id="VVIM01002034">
        <property type="protein sequence ID" value="KAB0790030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N3ZY93"/>
    <dbReference type="FunCoup" id="A0A5N3ZY93">
        <property type="interactions" value="407"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N3ZY93"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005899">
        <property type="term" value="C:insulin receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005009">
        <property type="term" value="F:insulin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043560">
        <property type="term" value="F:insulin receptor substrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042593">
        <property type="term" value="P:glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051897">
        <property type="term" value="P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00064">
        <property type="entry name" value="FU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001227">
        <property type="entry name" value="Tyrosine-protein kinase receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.20.20">
        <property type="entry name" value="Receptor L-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006211">
        <property type="entry name" value="Furin-like_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006212">
        <property type="entry name" value="Furin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000494">
        <property type="entry name" value="Rcpt_L-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036941">
        <property type="entry name" value="Rcpt_L-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF525">
        <property type="entry name" value="INSULIN-LIKE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00757">
        <property type="entry name" value="Furin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01030">
        <property type="entry name" value="Recep_L_domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00261">
        <property type="entry name" value="FU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="18" id="KW-0464">Manganese</keyword>
    <keyword evidence="14 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-0675">Receptor</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="15" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="796"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="23">
        <location>
            <begin position="388"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="23">
        <location>
            <begin position="499"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="23">
        <location>
            <begin position="693"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="22">
        <location>
            <begin position="858"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="887"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KAB0790030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1175" mass="133681" checksum="1CD92874A566723C" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N3ZYX6</accession>
    <name>A0A5N3ZYX6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_15416</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01001604">
        <property type="protein sequence ID" value="KAB0790249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N3ZYX6"/>
    <dbReference type="InParanoid" id="A0A5N3ZYX6"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000002">
        <property type="entry name" value="Transmembrane protease serine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252">
        <property type="entry name" value="ACROSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252:SF7">
        <property type="entry name" value="HYALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S1" evidence="3">
        <location>
            <begin position="1"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0790249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="202" mass="22940" checksum="C060C001D6BCA467" modified="2020-02-26" version="1" fragment="single">VPPSDLLLRLGEHDLSTDSEPYIHQERRVQIVAAHPQFDPRTFEYDLALLRFYEPVQFQPNIIPVCVPNTDENFVGRTAYVTGWGRLYEDGPLPSVLQQVAVPVINNTVCESMYRSAGYIEHIPHIFICAGWRKGGFDSCEGDSGGPMVIQREDKRFLLAGVISWGIGCAEPNQPGVYTRINRNRFLEYYYLRNDSLNGNDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A010</accession>
    <name>A0A5N4A010_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_14916</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000958">
        <property type="protein sequence ID" value="KAB0790642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A010"/>
    <dbReference type="InParanoid" id="A0A5N4A010"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF289">
        <property type="entry name" value="DDE TNP4 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="8">
        <location>
            <begin position="3"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0790642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="128" mass="14820" checksum="482D3D24B60B44A0" modified="2020-02-26" version="1">MQICDANIKILNCNARFPGSTHDSAIWDMSAVKRHLEEKYLTNELHSSWLIGYALQPWLLTPIENAEADPLSPQGRYTTQHILAKNVIERCFGVLKQRFRCLLKYRVLHYSPDRFAKIVWCCALCNTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A0G9</accession>
    <name>A0A5N4A0G9_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_15185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000741">
        <property type="protein sequence ID" value="KAB0790810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A0G9"/>
    <dbReference type="InParanoid" id="A0A5N4A0G9"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0790810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="93" mass="10348" checksum="021A86BF9814FD18" modified="2020-02-26" version="1" fragment="single">KMDELFGNKPWVEPVATASSSQNPEPSLNLPATMPSTPTRPSLSNTPQKTNSKKVVDILTKIREDRERHHSERMAKSSEAIALLKLLVEQIAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A0J6</accession>
    <name>A0A5N4A0J6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA-directed DNA polymerase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_14921</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000708">
        <property type="protein sequence ID" value="KAB0790845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A0J6"/>
    <dbReference type="InParanoid" id="A0A5N4A0J6"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1800.10">
        <property type="entry name" value="His-Me finger endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038563">
        <property type="entry name" value="Endonuclease_7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511">
        <property type="entry name" value="PROTEIN CBG23764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511:SF12">
        <property type="entry name" value="RHO TERMINATION FACTOR N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="His-Me finger endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="935"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0790845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="935" mass="108507" checksum="FD2E5D421056B5F7" modified="2020-02-26" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A0L9</accession>
    <name>A0A5N4A0L9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4371 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_15198</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000743">
        <property type="protein sequence ID" value="KAB0790808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A0L9"/>
    <dbReference type="InParanoid" id="A0A5N4A0L9"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37162:SF1">
        <property type="entry name" value="BED-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37162">
        <property type="entry name" value="HAT FAMILY DIMERISATION DOMAINCONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0790808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="161" mass="18706" checksum="96C0C882AFD62037" modified="2020-02-26" version="1">MNVFTSSRLPLDHIIGFGSDGCNTMFGSKNSVVTRLEINFPGIVIQKCVCHSLHLCASEACKVLPRYCEDLARDIFNFFKHSSKRQAQFQEFQEICNIEPHKILRPSQTRWLSLLMVVNRVIEQWEPLKLYFTQQWIGHRLLASETIANRYDTKLYLAINV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A1E4</accession>
    <name>A0A5N4A1E4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">LRRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_02888</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A1E4"/>
    <dbReference type="InParanoid" id="A0A5N4A1E4"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001164">
        <property type="entry name" value="GH01279p"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050333">
        <property type="entry name" value="SLRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45712">
        <property type="entry name" value="AGAP008170-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45712:SF22">
        <property type="entry name" value="INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN COMPLEX ACID LABILE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="27"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024364482" description="LRRCT domain-containing protein" evidence="3">
        <location>
            <begin position="22"/>
            <end position="836"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0791088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="836" mass="93303" checksum="7250F0F313A97C56" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A1Q5</accession>
    <name>A0A5N4A1Q5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Serine/threonine-protein phosphatase PGAM5, mitochondrial</fullName>
            <ecNumber evidence="3">3.1.3.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Phosphoglycerate mutase family member 5 homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Serine/threonine-protein phosphatase Pgam5, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PPYR_03057</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">1611_PpyrPB1</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Displays phosphatase activity for serine/threonine residues, and dephosphorylates and activates Pk92B kinase. Has apparently no phosphoglycerate mutase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 17">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts with Pk92B/ASK1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="3"/>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A1Q5"/>
    <dbReference type="FunCoup" id="A0A5N4A1Q5">
        <property type="interactions" value="987"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A1Q5"/>
    <dbReference type="OrthoDB" id="2118094at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090141">
        <property type="term" value="P:positive regulation of mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1240:FF:000009">
        <property type="entry name" value="serine/threonine-protein phosphatase PGAM5, mitochondrial isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051021">
        <property type="entry name" value="Mito_Ser/Thr_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20935">
        <property type="entry name" value="PHOSPHOGLYCERATE MUTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20935:SF0">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE PGAM5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00039765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00040722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAB0791257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="279" mass="31818" checksum="D2D6333379B30A95" modified="2020-02-26" version="1">MSTFTKMQKVALGLGTVGGSWCFFNFFNADRKVFNSWTTNFTPSVKWDDNWDHRSPTSLVHPKLFKLSDEKGDNQINENKERATPKVNRHIILIRHGQYNMSGETDKERYLTALGRSQAEYTGKRLLALGFPYTSMIKSTMTRAQETGSIISASLDNLPVSDCNLIREGAPIPPEPPVGHWRPEKQQFYQDGARIEAGFREYFYRADASQEKETYMIMVCHANVIRYFVCRALQFPAEAWLRISLNHGSITWLTITPKGRVILRALGDSGHMPVDAITY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A2F5</accession>
    <name>A0A5N4A2F5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3'-5' exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_03305</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A2F5"/>
    <dbReference type="FunCoup" id="A0A5N4A2F5">
        <property type="interactions" value="30"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A2F5"/>
    <dbReference type="OrthoDB" id="26838at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06148">
        <property type="entry name" value="Egl_like_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056589">
        <property type="entry name" value="WH_Egal-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46814">
        <property type="entry name" value="EGALITARIAN, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46814:SF1">
        <property type="entry name" value="EGALITARIAN, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23713">
        <property type="entry name" value="WHD_Egal"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00474">
        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3'-5' exonuclease" evidence="2">
        <location>
            <begin position="387"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="683"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="707"/>
            <end position="716"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0791505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="832" mass="94893" checksum="EF8963D124C9D5BC" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A3E3</accession>
    <name>A0A5N4A3E3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_03622</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A3E3"/>
    <dbReference type="InParanoid" id="A0A5N4A3E3"/>
    <dbReference type="OrthoDB" id="5348404at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061574">
        <property type="term" value="C:ASAP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12432">
        <property type="entry name" value="RRM_ACINU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034257">
        <property type="entry name" value="Acinus_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052793">
        <property type="entry name" value="EJC-associated_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032552">
        <property type="entry name" value="RSB_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46589">
        <property type="entry name" value="APOPTOTIC CHROMATIN CONDENSATION INDUCER IN THE NUCLEUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46589:SF1">
        <property type="entry name" value="APOPTOTIC CHROMATIN CONDENSATION INDUCER IN THE NUCLEUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16294">
        <property type="entry name" value="RSB_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="621"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="241"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="561"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="699"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="861"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="73"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="158"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="299"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="331"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="344"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="372"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="707"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="731"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="811"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="861"/>
            <end position="879"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0791822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="890" mass="100776" checksum="8D35A085315417DB" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A3P0</accession>
    <name>A0A5N4A3P0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_03743</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A3P0"/>
    <dbReference type="InParanoid" id="A0A5N4A3P0"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF7">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0791943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="237" mass="27311" checksum="B5531F7447863685" modified="2020-02-26" version="1" fragment="single">NIFAINGLPEEVFSDNGPPFNSWDFIEFANRYDIKLTTSSPRYPRSNGMVERTVQTVKSLLTKCLLEKEDPFAAILNYNVTAKQNLPSPSELLMGRRLRTSLPVSCKLLEPKFPIRGSKDQLKLLQERQKAYYDVSTKKLYELEPQQDVFVQEGIRNWKPGVVMKKSGPNDYIVRIGEADYRRNRQQINPRRMSEETLKCEPEVKVGTTSSETNPIVTSDYYTRSGRLVKIPDRLIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A3P9</accession>
    <name>A0A5N4A3P9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PPYR_03731</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DEAD box helicase family. DEAH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A3P9"/>
    <dbReference type="FunCoup" id="A0A5N4A3P9">
        <property type="interactions" value="2386"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A3P9"/>
    <dbReference type="OrthoDB" id="10025033at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17982">
        <property type="entry name" value="DEXHc_DHX37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000637">
        <property type="entry name" value="ATP-dependent RNA helicase DHX37/DHR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056371">
        <property type="entry name" value="DHX37-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF99">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX37-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23362">
        <property type="entry name" value="DHX37_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="259"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="447"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="156"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="515"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="125"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="181"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="526"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0791931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1106" mass="124761" checksum="FDE746AA88D5F8C4" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-06-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A3X3</accession>
    <name>A0A5N4A3X3_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_13930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0791969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A3X3"/>
    <dbReference type="InParanoid" id="A0A5N4A3X3"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0791969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="68" mass="8263" checksum="1F6C3F943DC2BFC1" modified="2020-02-26" version="1" fragment="single">YEKQYQLQLEREQQIRLMIEKEQRFIDQLRSEIAVSPNDKKSEKLVKAESNLQKLHTILQNHVRTQNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A4Z0</accession>
    <name>A0A5N4A4Z0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Integrase zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_14363</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A4Z0"/>
    <dbReference type="InParanoid" id="A0A5N4A4Z0"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040676">
        <property type="entry name" value="DUF5641"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF1">
        <property type="entry name" value="GAG-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18701">
        <property type="entry name" value="DUF5641"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase zinc-binding" evidence="1">
        <location>
            <begin position="173"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5641" evidence="2">
        <location>
            <begin position="253"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0792404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="287" mass="32703" checksum="1A8338F782D8BAEE" modified="2020-02-26" version="1">MDRSLTQLDPLSFDKDSDSTIKILGLQSTVSDDNLDLEKRKIALLVSSVPRLSLWDNLLTKFSSLSKILRTCAYVLRFVSYVKDPKGFDKRSHVTLKELDRALLILVKESQKMSFAKELAELSKTTPNIRSLPKYIRKLTPFLDQDGILRVGGRLKNTPLSYDHKHPCLLPSDHRLTNLIIEYTHIKYLHPGLQTTQFLLSQRFWIPSSKRVIKKVLSSCLRCFKCNPSSCTPLMGDLPKFRVNKIKCFTKSECFPGADGVTRVVNVKTQKGILRRPVSKLCLLPNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A557</accession>
    <name>A0A5N4A557_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CCR4-Not complex component Not1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_14412</name>
        <name evidence="3" type="ORF">PPYR_14414</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A557"/>
    <dbReference type="InParanoid" id="A0A5N4A557"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000288">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.800:FF:000001">
        <property type="entry name" value="CCR4-NOT transcription complex subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.790:FF:000001">
        <property type="entry name" value="Ccr4-not transcription complex subunit 1 isoform"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007196">
        <property type="entry name" value="CCR4-Not_Not1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040398">
        <property type="entry name" value="Not1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13162">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13162:SF8">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04054">
        <property type="entry name" value="Not1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCR4-Not complex component Not1 C-terminal" evidence="1">
        <location>
            <begin position="149"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0792453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0792455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="526" mass="60560" checksum="09820B177D94D10C" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A690</accession>
    <name>A0A5N4A690_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Fucosyltransferase</fullName>
            <ecNumber evidence="12">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PPYR_14737</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">1611_PpyrPB1</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Golgi apparatus</location>
            <location evidence="1 12">Golgi stack membrane</location>
            <topology evidence="1 12">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the glycosyltransferase 10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="12"/>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A690"/>
    <dbReference type="FunCoup" id="A0A5N4A690">
        <property type="interactions" value="27"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A690"/>
    <dbReference type="OrthoDB" id="427096at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008417">
        <property type="term" value="F:fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11660:FF:000006">
        <property type="entry name" value="Alpha-(1,3)-fucosyltransferase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11660">
        <property type="entry name" value="Glycosyl transferase family 10, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055270">
        <property type="entry name" value="Glyco_tran_10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031481">
        <property type="entry name" value="Glyco_tran_10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001503">
        <property type="entry name" value="Glyco_trans_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038577">
        <property type="entry name" value="GT10-like_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48438">
        <property type="entry name" value="ALPHA-(1,3)-FUCOSYLTRANSFERASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48438:SF1">
        <property type="entry name" value="ALPHA-(1,3)-FUCOSYLTRANSFERASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17039">
        <property type="entry name" value="Glyco_tran_10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00852">
        <property type="entry name" value="Glyco_transf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="Fucosyltransferase N-terminal" evidence="14">
        <location>
            <begin position="33"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Fucosyltransferase C-terminal" evidence="13">
        <location>
            <begin position="164"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAB0792778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="363" mass="42715" checksum="16790238AFC6BC1E" modified="2020-02-26" version="1">MKRYIQLRFVLILVIILIIIFAVQDYHTLRKNDRKYILYWTPFWWHEDFEVGFGDEPFENCEYTNCFATNNRNFMEISEFDAVIFHASIYDPKIHGKPPRRTANQAYIFCNMEAPVYIAPNFSQYDSFYNWTMTYRFDSDIVSRHGQFVEEESNYTLPSVAVIQKKAKLIAWFVSHCKTSSQREVLVAELQRFLPVDVYGLCGPLACEKTQRNELSSPKCYDMLEEDYKFYLSFENSLCKDYSTEKLYNALRKNVVPIVYGAGDYNMSAPPGSVINVADFETVEQLADHLWYLHENATAYLEYFHWKKRYKIAKVQKACEICRKLNLPQRTSIYHNLLEWSKGTRGEICKIGSDLPNILRNAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A6C0</accession>
    <name>A0A5N4A6C0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Multidrug resistance-associated protein lethal(2)03659</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PPYR_14768</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A6C0"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000973">
        <property type="entry name" value="Multidrug resistance-associated protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000014">
        <property type="entry name" value="Multidrug resistance-associated protein member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000163">
        <property type="entry name" value="Multidrug resistance-associated protein member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF448">
        <property type="entry name" value="FI20146P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024458338" description="Multidrug resistance-associated protein lethal(2)03659" evidence="11">
        <location>
            <begin position="18"/>
            <end position="1359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="424"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="457"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="797"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="838"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="920"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1023"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1049"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="356"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="513"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="797"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="1114"/>
            <end position="1346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="315"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="320"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAB0792809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1359" mass="149888" checksum="6CD50F64370A3BE0" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A715</accession>
    <name>A0A5N4A715_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ketimine reductase mu-crystallin</fullName>
            <ecNumber evidence="16">1.5.1.1</ecNumber>
            <ecNumber evidence="2">1.5.1.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">NADP-regulated thyroid-hormone-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PPYR_12731</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">1611_PpyrPB1</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(3R)-1,4-thiomorpholine-3-carboxylate + NAD(+) = 3,4-dehydrothiomorpholine-3-carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:12504"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58517"/>
            <dbReference type="ChEBI" id="CHEBI:176873"/>
            <dbReference type="EC" id="1.5.1.25"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="8">
            <dbReference type="Rhea" id="RHEA:12506"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(3R)-1,4-thiomorpholine-3-carboxylate + NADP(+) = 3,4-dehydrothiomorpholine-3-carboxylate + NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:12500"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58517"/>
            <dbReference type="ChEBI" id="CHEBI:176873"/>
            <dbReference type="EC" id="1.5.1.25"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="12">
            <dbReference type="Rhea" id="RHEA:12502"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(R)-lanthionine ketimine + NADPH + 2 H(+) = (3R,5R)-1,4-thiomorpholine-3,5-dicarboxylate + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:68040"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:176891"/>
            <dbReference type="ChEBI" id="CHEBI:176892"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:68041"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(S)-cystathionine ketimine + NADH + 2 H(+) = (3R,5S)-2,3,5,6,7-pentahydro-1,4-thiazepine-3,5-dicarboxylate + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:68032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:176808"/>
            <dbReference type="ChEBI" id="CHEBI:176810"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:68033"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(S)-cystathionine ketimine + NADPH + 2 H(+) = (3R,5S)-2,3,5,6,7-pentahydro-1,4-thiazepine-3,5-dicarboxylate + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:68036"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:176808"/>
            <dbReference type="ChEBI" id="CHEBI:176810"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:68037"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Delta(2)-thiazoline-2-carboxylate + NADPH + 2 H(+) = L-thiazolidine-2-carboxylate + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:68072"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:176895"/>
            <dbReference type="ChEBI" id="CHEBI:176896"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:68073"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-pipecolate + NAD(+) = Delta(1)-piperideine-2-carboxylate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:30807"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:61185"/>
            <dbReference type="ChEBI" id="CHEBI:77631"/>
            <dbReference type="EC" id="1.5.1.1"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="5">
            <dbReference type="Rhea" id="RHEA:30809"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-pipecolate + NADP(+) = Delta(1)-piperideine-2-carboxylate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12524"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:61185"/>
            <dbReference type="ChEBI" id="CHEBI:77631"/>
            <dbReference type="EC" id="1.5.1.1"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="14">
            <dbReference type="Rhea" id="RHEA:12526"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-proline + NAD(+) = 1-pyrroline-2-carboxylate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20321"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:39785"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.1"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="13">
            <dbReference type="Rhea" id="RHEA:20323"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-proline + NADP(+) = 1-pyrroline-2-carboxylate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20317"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:39785"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.1"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="7">
            <dbReference type="Rhea" id="RHEA:20319"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homodimer. Binds the thyroid hormone triiodothyronine (T3); T3 binding inhibits enzymatic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ornithine cyclodeaminase/mu-crystallin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.1" evidence="16"/>
    <dbReference type="EC" id="1.5.1.25" evidence="2"/>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A715"/>
    <dbReference type="FunCoup" id="A0A5N4A715">
        <property type="interactions" value="11"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A715"/>
    <dbReference type="OrthoDB" id="41492at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042562">
        <property type="term" value="F:hormone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050241">
        <property type="term" value="F:pyrroline-2-carboxylate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047127">
        <property type="term" value="F:thiomorpholine-carboxylate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1780.10">
        <property type="entry name" value="ornithine cyclodeaminase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003462">
        <property type="entry name" value="ODC_Mu_crystall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023401">
        <property type="entry name" value="ODC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13812">
        <property type="entry name" value="KETIMINE REDUCTASE MU-CRYSTALLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13812:SF19">
        <property type="entry name" value="KETIMINE REDUCTASE MU-CRYSTALLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02423">
        <property type="entry name" value="OCD_Mu_crystall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001439">
        <property type="entry name" value="CryM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00033420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00093190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00093197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00093203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00093226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00093227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00093248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00093250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00093263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00093264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00093273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00093567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00093598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00093650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAB0793111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="313" mass="34588" checksum="CB44EF84DF5188B6" modified="2020-02-26" version="1">MSALLHINENRVLQLLDWDKVFHVIEGALESVASNHVIQSARSVIDLKETNFMFVMPGKLRDDNGETLGCKIACHFPGNTTLPPLMANILLMDALTGELQAVIAATGITAWRTAAASAVATKYLHNENNKILAIIGAGAQGRIHAICLSYFFKFKEVRVWNRNRERAVRLVTELSNDSKWKCSFKACETVQSCLSDADVVVTTTGTDVSIVKLDWLKPSAHINAVGVGLDCREIDDEVYKAANVYIDHWDGAKEELKHLIDIGIQFKGQIGDLIRGSIKPPPKNSLTIFQSLGMAVEDCAVARMIYDLHMQNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A7E9</accession>
    <name>A0A5N4A7E9_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_12845</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A7E9"/>
    <dbReference type="FunCoup" id="A0A5N4A7E9">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A7E9"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024286589" evidence="2">
        <location>
            <begin position="20"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="148"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0793225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="465" mass="51095" checksum="1F8A56AB9C8414F0" modified="2020-02-26" version="1">MRIYLLLAVISATIIAINSNPVVITAHEDSKSVASPEAIASEGKIQEESTGVFKKDAEAEASAVKSTPEDASQPLVAPAGEKPKEKGRQSGSEDDDDDDDDLGIGDDDDDDDDDDDDDDYGLDGLFDDFLGDDDDDDDDDDDDDDDTPSSQPAPAPSQVVEPEDLSPDEELNAVEQAEGASDGSYVQNRMPSVYIAKYNRFLDTILTRINKILASSYDPVRVKLQTPDSKKNSKTKSGNKNKSKKNKKKNPNISRVDMPDGRHKMAEIPIARSTESELSFVLVSKTGNNSTSENRAVPAKNKKRRRNNKNKGKKNTKNKSNTKAARKSQKARATLYGLSSIRRDGDVNVNVASNYTTVKTNFVIGPLTLRVEREFSNGEKREMKSATAVTNEMHGRLNLRIVHGEAATLHSIRVLQPKQVRVESKDNHDKTSEYIWKRSSHIAHVVSSKLAKAAKSMLRPPPSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-06-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A812</accession>
    <name>A0A5N4A812_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_13074</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A812"/>
    <dbReference type="InParanoid" id="A0A5N4A812"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0793454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="125" mass="14453" checksum="4D02CD7D33EE4303" modified="2020-02-26" version="1">MLKKALIVNGNADISRFVARTIITVIAFMIAQNVNYVPKKSKILSVEDTRKFILEASDDFLLCKVVLIFGLYGACRRDELLKFIKNMLNYVLLMLERDAFFWDTEKESALLSRLVCIPLVVYREK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A8H8</accession>
    <name>A0A5N4A8H8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Serine/threonine-protein kinase ATM</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PPYR_13232</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">1611_PpyrPB1</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PI3/PI4-kinase family. ATM subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A5N4A8H8">
        <property type="interactions" value="1490"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A8H8"/>
    <dbReference type="OrthoDB" id="381190at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05171">
        <property type="entry name" value="PIKKc_ATM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000023">
        <property type="entry name" value="Serine/threonine-protein kinase ATM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038980">
        <property type="entry name" value="ATM_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003151">
        <property type="entry name" value="PIK-rel_kinase_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044107">
        <property type="entry name" value="PIKKc_ATM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021668">
        <property type="entry name" value="TAN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37079">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE ATM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37079:SF4">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE ATM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02259">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01342">
        <property type="entry name" value="TAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FAT" evidence="16">
        <location>
            <begin position="1749"/>
            <end position="2343"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="15">
        <location>
            <begin position="2453"/>
            <end position="2769"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="17">
        <location>
            <begin position="2789"/>
            <end position="2821"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00073111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAB0793612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="2821" mass="325183" checksum="567020D5DF23EC19" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2024-11-27" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A8V3</accession>
    <name>A0A5N4A8V3_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_13364</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A8V3"/>
    <dbReference type="InParanoid" id="A0A5N4A8V3"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010997">
        <property type="term" value="F:anaphase-promoting complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990757">
        <property type="term" value="F:ubiquitin ligase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905786">
        <property type="term" value="P:positive regulation of anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033010">
        <property type="entry name" value="Cdc20/Fizzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918">
        <property type="entry name" value="CELL DIVISION CYCLE 20 CDC20 FIZZY -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918:SF52">
        <property type="entry name" value="PROTEIN CORTEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="148"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0793744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="358" mass="40169" checksum="05E02CCC9480A5E0" modified="2020-02-26" version="1">MVNGGRGGVHLVPSVHKKKPISLPSDTSQHSTDWGSTGYLASVFAGEVYLWSSQKNDPKRVTNTGGKVGKCIRWNKNGTALAMAYELKGLAIFNSVKNKIVYEETCNCLSACCITAMEWTTSNMLITGCKLGRVVVWDEQLRYETDRFWSHDGMIIEMRLSCDEKYLVTSGEDNNVRIWFWPQLREHFQVSYTAPVRGIAWHPWNYSLLAIGGGVGQGCVTIWNASSMQQKGRKSPKENNAFAVDSLAWNPLTGELVVSYWHRRTNNDGVPRSSIIVLSNLTTEVDEIEWHVGRVLYLLWGNGGATLATAATDENLCMWNFFGNSPDTLKKLKKKKRDLCSSGNYMFETAKIFGQCIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A921</accession>
    <name>A0A5N4A921_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_13427</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A921"/>
    <dbReference type="InParanoid" id="A0A5N4A921"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000023">
        <property type="entry name" value="Pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF9">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="557"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="262"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0793807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="843" mass="95994" checksum="43A1ECD8B38F468C" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AAJ5</accession>
    <name>A0A5N4AAJ5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PPYR_11138</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">1611_PpyrPB1</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0794299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AAJ5"/>
    <dbReference type="InParanoid" id="A0A5N4AAJ5"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13990">
        <property type="entry name" value="STKc_TLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000037">
        <property type="entry name" value="Serine/threonine-protein kinase tousled-like 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22974">
        <property type="entry name" value="MIXED LINEAGE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22974:SF23">
        <property type="entry name" value="TOUSLED-LIKE KINASE, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="442"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="69"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="323"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="724"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="226"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="393"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="137"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="158"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="323"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="356"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="735"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="471"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAB0794299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="768" mass="87535" checksum="11EA5D4205D67F8E" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AAP4</accession>
    <name>A0A5N4AAP4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PPIase cyclophilin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_11167</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CFAP97 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0794328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AAP4"/>
    <dbReference type="FunCoup" id="A0A5N4AAP4">
        <property type="interactions" value="53"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AAP4"/>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029488">
        <property type="entry name" value="Hmw/CFAP97"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13879">
        <property type="entry name" value="Hmw_CFAP97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="2">
        <location>
            <begin position="207"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0794328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="368" mass="42762" checksum="00CD593B504FF111" modified="2020-02-26" version="1">MKKKSNKFKPFLKSPRYLVGQVDQDTIISDLRNYNNHRYQLFTAKPRIDTKPLPMNPHKYVNSQRLVNDRFRMSEINRQNRAMIQKINVINRNGGWIDTFNPIAYSYRSRWRAHELNMKEIERTNIVTYQKIVNAKSEYETKELDENWKHVVEKLRNSSKYPCVLLDKKSLDYHIRQQPSISSLEDLEKNERPKVFMDFRVKDGAYLGRIIIELYSDYVPVTVQNFISLCCKLDGLTYKNCQVHRVAPGKYVETGDITKGNGKGGTSIYGETFPEENHRLKHTKMGVLSMVPVRNGLNNSQFSITFTAIEKFDDTRVVFGKVIKGNTTLCKLNDLGKPFGRPIAPILINNCGKYTKGKTPSTLRKFKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ABD6</accession>
    <name>A0A5N4ABD6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PPYR_01647</name>
        <name evidence="9" type="ORF">PPYR_11407</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0794568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ABD6"/>
    <dbReference type="InParanoid" id="A0A5N4ABD6"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF237">
        <property type="entry name" value="SI:CH73-257C13.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="8">
        <location>
            <begin position="196"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0794568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0804677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="397" mass="44766" checksum="FA43DA80593CB866" modified="2020-02-26" version="1">MSNKDSIIHSTILGTSRKRATAALLAFWTSVVDSDDDDDNVIVSQQLLTTREHGESKRVCIKNYVAIVESYSLDGIVDFRKHFRLTKMSFEEVLIKIGDKLSMASSVHHTGRPGNDAKTQLLVGLWILANQESYRTVADRFDLTISTAWCYFRKVVDTLVSIASDVIQWPKNESQRQCFSTEFRKRQGFPNVIGAIDGTHIPIVAPHNMANSYINRNKYYSIVLQGVCNARYKFIDCYAGPPGSVHDARVLKMSPLGKKLNHNIHDLVPSDYHLLGDSAYSNASHLLTPYKDNGHLSRKQKNYNYKHSATRVAIEQAYGLLKGRFRILRYVNIYDTKVIPSVIISCCVLHNICVDANDVDVEPYQEDADANVAVGINDRNLDTKGRIKRDDIAEIIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ABH6</accession>
    <name>A0A5N4ABH6_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Luciferin sulfotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_00003</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfotransferase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0794676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ABH6"/>
    <dbReference type="SMR" id="A0A5N4ABH6"/>
    <dbReference type="FunCoup" id="A0A5N4ABH6">
        <property type="interactions" value="27"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4ABH6"/>
    <dbReference type="OrthoDB" id="205623at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001762">
        <property type="entry name" value="Sulfotransferase 3, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11783">
        <property type="entry name" value="SULFOTRANSFERASE SULT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="3">
        <location>
            <begin position="80"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0794676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="370" mass="43274" checksum="E299E8B1EBB6F05D" modified="2020-02-26" version="1">MFASILGKIPQYSTISSKCSLKECRKVKKVENSDEIGEIIHRDFLDPFCNEYVLIGEEETSLGINYLQFEEEIRTFEIRDSDIIVASYPKAGTTWTQELVWLIGNDLDFKAAEEHLDKRFPHFELCTIVNFAKMTEMLGSTRPEYIGNSINYLRDLEGTRFIKTHLTYNLLPEQILNGNRKPKIIYVMRDPKDVCVSYYHHGRLIQGWRADFQNFSKVFLSEKIMFGSYWKHVLGYWEHRDKPNVLILTYEEMKKDLLSVIRKTAQFLDKKLNENKIPQLLKHLSFESMKNNRAVNQQDKIESRMKHKLVPEQGAFMRSGTSQNYKGEMSEELILKFDEWTKKSISGSSFVTEPIADLYLNTSQKSVPKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ABM0</accession>
    <name>A0A5N4ABM0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PPYR_11551</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0794712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="interactions" value="286"/>
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    <dbReference type="InParanoid" id="A0A5N4ABM0"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15505">
        <property type="entry name" value="PHD_ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
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    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
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        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
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    <dbReference type="PANTHER" id="PTHR24394:SF29">
        <property type="entry name" value="MYONEURIN"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="829"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="9">
        <location>
            <begin position="1469"/>
            <end position="1520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="337"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="879"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1007"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1064"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1247"/>
            <end position="1298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1342"/>
            <end position="1464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="346"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="400"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="421"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="479"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="879"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="917"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="973"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1014"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1064"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1114"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1160"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1203"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1269"/>
            <end position="1285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1438"/>
            <end position="1448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="1455"/>
            <end position="1464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0794712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1530" mass="173904" checksum="41A51E0B5E50FDB6" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ABX7</accession>
    <name>A0A5N4ABX7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">VWFD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PPYR_11651</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the serine protease inhibitor-like (TIL domain-containing) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="alpha-tectorin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
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        <property type="match status" value="5"/>
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    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
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        <property type="entry name" value="Mucin_vWF_Thrombospondin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036084">
        <property type="entry name" value="Ser_inhib-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002919">
        <property type="entry name" value="TIL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014853">
        <property type="entry name" value="VWF/SSPO/ZAN-like_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001007">
        <property type="entry name" value="VWF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001846">
        <property type="entry name" value="VWF_type-D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11339">
        <property type="entry name" value="EXTRACELLULAR MATRIX GLYCOPROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11339:SF386">
        <property type="entry name" value="HEMOLECTIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08742">
        <property type="entry name" value="C8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01826">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00094">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00832">
        <property type="entry name" value="C8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00215">
        <property type="entry name" value="VWC_out"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00216">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57603">
        <property type="entry name" value="FnI-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57567">
        <property type="entry name" value="Serine protease inhibitors"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51233">
        <property type="entry name" value="VWFD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0768">Sushi</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024362255" description="VWFD domain-containing protein" evidence="9">
        <location>
            <begin position="24"/>
            <end position="1530"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="98"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="11">
        <location>
            <begin position="134"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="192"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="12">
        <location>
            <begin position="338"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="12">
        <location>
            <begin position="699"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="12">
        <location>
            <begin position="1175"/>
            <end position="1343"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="102"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="120"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="195"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="213"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAB0794812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1530" mass="168000" checksum="88B13B869B2EB6C3" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2024-11-27" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ACF8</accession>
    <name>A0A5N4ACF8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">SID1 transmembrane family member 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PPYR_11835</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SID1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0794996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ACF8"/>
    <dbReference type="InParanoid" id="A0A5N4ACF8"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051033">
        <property type="term" value="F:RNA transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025958">
        <property type="entry name" value="SID1_TM_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12185:SF14">
        <property type="entry name" value="CHOLESTEROL UPTAKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12185">
        <property type="entry name" value="SID1 TRANSMEMBRANE FAMILY MEMEBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13965">
        <property type="entry name" value="SID-1_RNA_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024402097" description="SID1 transmembrane family member 1" evidence="9">
        <location>
            <begin position="28"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="314"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="400"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="454"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="492"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="518"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="550"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="574"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="628"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="658"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="689"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="739"/>
            <end position="758"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0794996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="773" mass="88268" checksum="C048CE5E8C8CAD32" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ACW8</accession>
    <name>A0A5N4ACW8_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_11937</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0795098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ACW8"/>
    <dbReference type="InParanoid" id="A0A5N4ACW8"/>
    <dbReference type="OrthoDB" id="6776666at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="505"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="505"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0795098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="596" mass="68708" checksum="18507BB67E684F81" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AE55</accession>
    <name>A0A5N4AE55_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Caspase family p20 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_12357</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase C14A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0795518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AE55"/>
    <dbReference type="FunCoup" id="A0A5N4AE55">
        <property type="interactions" value="122"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AE55"/>
    <dbReference type="OrthoDB" id="6097640at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1470">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002398">
        <property type="entry name" value="Pept_C14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002138">
        <property type="entry name" value="Pept_C14_p10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001309">
        <property type="entry name" value="Pept_C14_p20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015917">
        <property type="entry name" value="Pept_C14A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47901">
        <property type="entry name" value="CASPASE RECRUITMENT DOMAIN-CONTAINING PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47901:SF8">
        <property type="entry name" value="CASPASE-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00376">
        <property type="entry name" value="IL1BCENZYME"/>
    </dbReference>
    <dbReference type="SMART" id="SM00115">
        <property type="entry name" value="CASc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50207">
        <property type="entry name" value="CASPASE_P10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50208">
        <property type="entry name" value="CASPASE_P20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Caspase family p20" evidence="8">
        <location>
            <begin position="183"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="Caspase family p10" evidence="7">
        <location>
            <begin position="331"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="33"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0795518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="413" mass="46103" checksum="C81D73AF13A22F9B" modified="2020-02-26" version="1">MPLSFFSKKSKSSKSKETSSVSKSLTITKNGESTVTTSSTSMTRQSSSTSHSSEVQVVSSSPTFDLNNIKTQGPIFDFKIPKMATDAKTFPKTYQPRPYRSACSPNFQPLTTAHSASTSNNKFNYNKPISPVPPRNVYVKNLVANPGISDLDCKLNVSVKQSAKFYDDCNESKVPVYRTRSKHRGKLLLINNVKFINDRHEREGAELDDANLTKLFQEIGFEVIRHQNLTKTDMEKKIKTFRDSTSLKKVDIGCVIVMSHGTGHERSDSTQVLCSDGLLIETTWIIDQFNSTLCKNLGAKPKIFIFQCCRGSAQDVQYDAVPLSTDQRSLSDMLLAYSTVPGFVSHRDPVHGTLYIQAVCKVFMEHAHDTHVEDLLKMVDSKLSMHVGAGLKQTSSFENRGFKTCYLHPKLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AE97</accession>
    <name>A0A5N4AE97_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_09718</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0795657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AE97"/>
    <dbReference type="FunCoup" id="A0A5N4AE97">
        <property type="interactions" value="719"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AE97"/>
    <dbReference type="OrthoDB" id="273823at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14951">
        <property type="entry name" value="NHL-2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045302">
        <property type="entry name" value="NHL2_NHL_rpt_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001258">
        <property type="entry name" value="NHL_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46388">
        <property type="entry name" value="NHL REPEAT-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46388:SF2">
        <property type="entry name" value="NHL REPEAT-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01436">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13905">
        <property type="entry name" value="Thioredoxin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="25"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0795657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="700" mass="77468" checksum="8C2C684CABE1CD43" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AEX8</accession>
    <name>A0A5N4AEX8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SOWAHA-C winged helix-turn-helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_09849</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0795788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AEX8"/>
    <dbReference type="InParanoid" id="A0A5N4AEX8"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058889">
        <property type="entry name" value="WHD_SOWAHA-C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14491">
        <property type="entry name" value="SOSONDOWAH, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14491:SF7">
        <property type="entry name" value="SOSONDOWAH, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25877">
        <property type="entry name" value="WHD_SOWAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="SOWAHA-C winged helix-turn-helix" evidence="4">
        <location>
            <begin position="5"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="95"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="114"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="160"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0795788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="282" mass="31345" checksum="C5901847D169B314" modified="2020-02-26" version="1">MAANELSIDVIRDYFIEKGGIVSNRDVVKHFKRYLTDPSTRDEARTTFKKLINTLATTKTEGDEKFLILKPKYSLCPDLPAIPITSPKPCLDPINSIGIPVSPSHSIQDASPRRQPPPYRPPPPPPPTTPSPNVSCDNISISSSISLAESIAPQAPPRRRNSEKSKMEEPPRDDCENPGVENDKQPISVKERTQKFNRMASVEDELSPRNQKGRKIPDKGADEDDGASVTSLDPKKCTEWLVTAAKGDYQELAKLASDDPRLVKLKDPFTVHRTSLGRQTWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AGD9</accession>
    <name>A0A5N4AGD9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GST N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_10339</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AGD9"/>
    <dbReference type="InParanoid" id="A0A5N4AGD9"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43969">
        <property type="entry name" value="GLUTATHIONE S TRANSFERASE D10, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43969:SF9">
        <property type="entry name" value="GLUTATHIONE S TRANSFERASE D10, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13417">
        <property type="entry name" value="GST_N_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0796278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="62" mass="6893" checksum="CD747B46A8610B51" modified="2020-02-26" version="1">MTLRLYYSEMSPTSRAVLLTAQAIGLELELVPINIVCGEHLTSEFKAMNPQHTIPTLDDDGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AH86</accession>
    <name>A0A5N4AH86_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_10776</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AH86"/>
    <dbReference type="InParanoid" id="A0A5N4AH86"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001667">
        <property type="term" value="P:ameboidal-type cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022412">
        <property type="term" value="P:cellular process involved in reproduction in multicellular organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003006">
        <property type="term" value="P:developmental process involved in reproduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035099">
        <property type="term" value="P:hemocyte migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035006">
        <property type="term" value="P:melanization defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0796715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="141" mass="16011" checksum="00DB0B396B76E374" modified="2020-02-26" version="1">MYESTVTNDKTSEVAVLIDTVADEDYDDLRPITYNLAKVILVCYSVDDELSFFHVVRKWVPEITKHQSRIPFILVGTKSDLVAKISTNEGKQLAEKLHAAAFLECSSKDGTGIKEVFTTALNIYTRSFAYKRRNKRPCNIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AIJ9</accession>
    <name>A0A5N4AIJ9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PPYR_08113</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">1611_PpyrPB1</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Microsome membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 15">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AIJ9"/>
    <dbReference type="InParanoid" id="A0A5N4AIJ9"/>
    <dbReference type="OrthoDB" id="1103324at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008395">
        <property type="term" value="F:steroid hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006805">
        <property type="term" value="P:xenobiotic metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000238">
        <property type="entry name" value="Cytochrome P450 2A6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050182">
        <property type="entry name" value="Cytochrome_P450_fam2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300:SF376">
        <property type="entry name" value="CYTOCHROME P450 15A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300">
        <property type="entry name" value="CYTOCHROME P450 508A4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 14 15" id="KW-0349">Heme</keyword>
    <keyword evidence="11 14 15" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0492">Microsome</keyword>
    <keyword evidence="12 15" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="10 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="14">
        <location>
            <position position="452"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAB0797119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="505" mass="57632" checksum="4E8D1ED830BC612F" modified="2020-02-26" version="1">MITSIILVILSTLVYIFVYRLSKPKLENFPPGPPSLPIWGGYWFLLLANYNFTHKAVEVLSRRYKSDLVGIMLGRTPTVLVTGHDLVKETLTRQEFIGRIDCYPNRFRSMGDLLGVIFTSGDYWRQQRRFALRQLRDFGFGRRFPTTEQMLESEVRNLIGQISSNPHPDNHDVQQKPGRILLPDLFYGMLSNSMLQMLVGKRFEDKQLRTIARSTLRFFRNMDTTGRALSITPWIRHVAPEYFGATPTLEENKKIQDFFMTLVEERTKTFSDDHHGDFLDTYISNMQRLGKGGGPSGSFNEMQMIWTAIDFFFPSPNVIGPSLNMLWARLCNHPEVQAKIQTEIEQVVGRARLPNLDDRKNMPYTEAVIRESLRIDPVLPINTARRVLEDTTLGGYSLPKGTCLLISLSSANRDRRVWTDPDVFKPERFLDADGNLLKKDIGLSFGGGKRLCPGETFSRHAMFLVLSGLLQNFTFVPVDGAPDPNGTMYGFICDIPPFWVDAVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AKK7</accession>
    <name>A0A5N4AKK7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Regulating synaptic membrane exocytosis protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PPYR_08873</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
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            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Synapse</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAB0797880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytoskeleton of presynaptic active zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042734">
        <property type="term" value="C:presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:small GTPase binding"/>
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    <dbReference type="GO" id="GO:0044325">
        <property type="term" value="F:transmembrane transporter binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048791">
        <property type="term" value="P:calcium ion-regulated exocytosis of neurotransmitter"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0050806">
        <property type="term" value="P:positive regulation of synaptic transmission"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:regulation of synaptic plasticity"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="PDZ_RIM-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Regulating synaptic membrane exocytosis protein 1, putative"/>
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        <property type="entry name" value="Regulating synaptic membrane exocytosis protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Uncharacterized protein, isoform D"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="C2_domain_sf"/>
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        <property type="entry name" value="PDZ"/>
    </dbReference>
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        <property type="entry name" value="PDZ_sf"/>
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        <property type="entry name" value="Rab_BD"/>
    </dbReference>
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        <property type="entry name" value="Rim-like"/>
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        <property type="entry name" value="RIM_Znf"/>
    </dbReference>
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        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
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        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
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        <property type="entry name" value="RAB3 INTERACTING MOLECULE, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12157">
        <property type="entry name" value="REGULATING SYNAPTIC MEMBRANE EXOCYTOSIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="C2"/>
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        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="RIM2a_ZnF"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50916">
        <property type="entry name" value="RABBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0770">Synapse</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RabBD" evidence="12">
        <location>
            <begin position="4"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="11">
        <location>
            <begin position="68"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="10">
        <location>
            <begin position="392"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="9">
        <location>
            <begin position="543"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="9">
        <location>
            <begin position="1135"/>
            <end position="1254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="136"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="214"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
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            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="671"/>
            <end position="822"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="876"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="908"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="962"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="147"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="248"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="357"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="680"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="708"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="723"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="735"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="793"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
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            <end position="974"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1016"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1042"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
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            <end position="1072"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1084"/>
            <end position="1103"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAB0797880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1262" mass="141391" checksum="570BDBFDA6A624E5" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AL01</accession>
    <name>A0A5N4AL01_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_08984</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asteroid family.</text>
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    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Asteroid"/>
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    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15665">
        <property type="entry name" value="ASTEROID PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15665:SF1">
        <property type="entry name" value="PROTEIN ASTEROID HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="335"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="685"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="697"/>
            <end position="706"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0797991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="730" mass="85008" checksum="450E853C61E1B058" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ALE5</accession>
    <name>A0A5N4ALE5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA-binding protein 48</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_09086</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RBM48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ALE5"/>
    <dbReference type="FunCoup" id="A0A5N4ALE5">
        <property type="interactions" value="18"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4ALE5"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12442">
        <property type="entry name" value="RRM_RBM48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039599">
        <property type="entry name" value="RBM48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034264">
        <property type="entry name" value="RBM48_RRM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20957">
        <property type="entry name" value="RNA-BINDING PROTEIN 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20957:SF0">
        <property type="entry name" value="RNA-BINDING PROTEIN 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0798093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="187" mass="21941" checksum="A1374445E80192C4" modified="2020-02-26" version="1">MEGSSTSTILKEEEHHKQQQLCESRPAYRQGRKLVAVKVYTITSESSHLFIYGVPKINLRNELKTACLKYGKIKAFHCVTGYKTEIFTECYHVHFERIQSARVAKRLLDNKSFYGGILHVCYAPEYETIEDTRAKLQHRLKDVRNRLEKQNVWPNQSEHKVELDDYINTTKSQLKKKRKYGAAFKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2024-11-27" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ALL0</accession>
    <name>A0A5N4ALL0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein big brother</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PPYR_09225</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CBF-beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ALL0"/>
    <dbReference type="InParanoid" id="A0A5N4ALL0"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016513">
        <property type="term" value="C:core-binding factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.250.10">
        <property type="entry name" value="Core binding factor, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003417">
        <property type="entry name" value="CBF_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036552">
        <property type="entry name" value="CBF_bsu_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10276:SF3">
        <property type="entry name" value="CORE-BINDING FACTOR SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10276">
        <property type="entry name" value="CORE-BINDING FACTOR, BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02312">
        <property type="entry name" value="CBF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50723">
        <property type="entry name" value="Core binding factor beta, CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="94"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="56"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0798232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="134" mass="15375" checksum="F2D2F6B1B3F7A042" modified="2020-02-26" version="1">MQNRECDFDKEPGKIHIKSSLIMNGVCVRWRGWIDLERLDGVGCLEYCEDRAAAEDALLREQIERYNQRLREFEDKQRGYRSQDRIDQDLELRMANSLHGSAHHGHHGGPVSSRCHGPPRHGLPLQVGLPLTPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AMV0</accession>
    <name>A0A5N4AMV0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine/threonine-protein phosphatase 1 regulatory subunit 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PPYR_09531</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AMV0"/>
    <dbReference type="FunCoup" id="A0A5N4AMV0">
        <property type="interactions" value="1319"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AMV0"/>
    <dbReference type="OrthoDB" id="2138378at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072357">
        <property type="term" value="C:PTW/PP1 phosphatase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008157">
        <property type="term" value="F:protein phosphatase 1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.10">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035441">
        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017923">
        <property type="entry name" value="TFIIS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46557">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46557:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08711">
        <property type="entry name" value="Med26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47676">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51319">
        <property type="entry name" value="TFIIS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS N-terminal" evidence="5">
        <location>
            <begin position="71"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="4">
        <location>
            <begin position="938"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="2">
        <location>
            <begin position="938"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="166"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="231"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="903"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="231"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="254"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="265"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="285"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="309"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="327"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="366"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="457"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="504"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="518"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="554"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="569"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0798538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="966" mass="108520" checksum="2434A0DC6C2CE346" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AP47</accession>
    <name>A0A5N4AP47_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PPYR_06979</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AP47"/>
    <dbReference type="FunCoup" id="A0A5N4AP47">
        <property type="interactions" value="12"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AP47"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20628">
        <property type="entry name" value="CYP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
        <property type="entry name" value="Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291:SF106">
        <property type="entry name" value="CYTOCHROME P450 4G1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="495"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0799099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="552" mass="62835" checksum="FE29540CA31BAA56" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4APN9</accession>
    <name>A0A5N4APN9_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_07113</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4APN9"/>
    <dbReference type="InParanoid" id="A0A5N4APN9"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0799233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="315" mass="35314" checksum="17CC95758CE2EB96" modified="2020-02-26" version="1">MRFSNLSKIFNYAPISVGKRFVGDVTYFPSFSGLETTYVYAVQATGSKCVLFLKCERSDESRSLEMESADDLRQRILKRLNIKTDEVPAPPTFEILSLDEIRKRKKKYGDTDFENPTEGDIGIKVKRQKVFLSNKPSTDITDIKIKTLAEIRAEKGKGVTADDGCFEVSSTSNPEELQETTEAPAPPKIIPEKRLKRKVSSSTDSSNPTKVKLKRIKLAADDVESTSPEVPHENNDELEAEKSPQPQIQDANENERDDAINDDVSENQCDKSSSKGDMSKLDDILLLDDEDIEDSSINLKAEEDILKDIDELLND</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4APZ0</accession>
    <name>A0A5N4APZ0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">nucleoside diphosphate phosphatase</fullName>
            <ecNumber evidence="3">3.6.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PPYR_07305</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GDA1/CD39 NTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.6" evidence="3"/>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4APZ0"/>
    <dbReference type="FunCoup" id="A0A5N4APZ0">
        <property type="interactions" value="1108"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4APZ0"/>
    <dbReference type="OrthoDB" id="6372431at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017110">
        <property type="term" value="F:nucleoside diphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd24046">
        <property type="entry name" value="ASKHA_NBD_NTPDase5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000052">
        <property type="entry name" value="Ectonucleoside triphosphate diphosphohydrolase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.150">
        <property type="entry name" value="Exopolyphosphatase. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000407">
        <property type="entry name" value="GDA1_CD39_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782">
        <property type="entry name" value="ADENOSINE/GUANOSINE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782:SF127">
        <property type="entry name" value="NTPASE, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01150">
        <property type="entry name" value="GDA1_CD39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="232"/>
            <end position="236"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0799425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="465" mass="51644" checksum="9FF5AE447D11B12C" modified="2020-02-26" version="1">MNSELRRRKLKESNGRPLPKRKRKDADTSSLHRSLLCLILSGTILTVFIILYIDYIPWHLGHRTVDSIAKRFGYDKPVHAVVIDAGSTGSRVLAFTFHEAYLDGHLILDKELFEYTKPGISVFADKPEKAAASISTLLEKAKKEIPKEYWSKTPLILRATAGLRLLPQEKAENLLNTLRAMFKKTPFVTNDDSVAIMDGTDEGIFSWFTVNFLLERIGGNAARTVAALDLGGGSTQVTFSPTTPETLSQTEHIHQAIAPQGSIPVFTNSYLGLGLMAARKEVITYNNNGLVNITSECVNPIISNKKFHYAGVDYLVSGLKENYPTIKVPGNSYTTAEERPIVSFDTCSEIVTSYIRSIAKPIGELPHKQINAFSYYFDRAAEVALIDERKGGLVKVSQFKTAAQNVCKQANADQPFMCLDLTFIWSLLENGFGLRADTNIFLFKKVNGHEISWALGVAYSLLKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AR52</accession>
    <name>A0A5N4AR52_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4806 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_07687</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AR52"/>
    <dbReference type="InParanoid" id="A0A5N4AR52"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032071">
        <property type="entry name" value="DUF4806"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34153:SF2">
        <property type="entry name" value="SI:CH211-262H13.3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34153">
        <property type="entry name" value="SI:CH211-262H13.3-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16064">
        <property type="entry name" value="DUF4806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4806" evidence="2">
        <location>
            <begin position="234"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0799807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="337" mass="39266" checksum="DAF12E97C130D1D4" modified="2020-02-26" version="1">MSWTVVEFVETKEVEAVPTKWIFNGQCYWPPQARDKVLHEIKQNSQPNTCWPLYDIRIFKDSTYKDYGIACKKSSNAQFTSDLNTTDDEHVSTKRKTVPSRRYMADSTDSEEDTIVMKKPPVLKYDNQSQRNSKKTSKATTDNNNLHIISNQLVTPSSVGTLSVSEFRPEAVIRSKSTTCSCTCQLHQSKNENMLREILRQLTTMKASLLQFNEDVQKLHGNKTKEFYRENFLNNFHLPINGEMELKELDSYLKSDINFKGTVEDISRIGGSNIYDFVRRSLSVLITDEVAKEYSYYGVKKKKIFKSLRLCDLLLVRTPRRYQYFNYRSRCNIKLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ARS9</accession>
    <name>A0A5N4ARS9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Lipase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_07886</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0800006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ARS9"/>
    <dbReference type="FunCoup" id="A0A5N4ARS9">
        <property type="interactions" value="49"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4ARS9"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017171">
        <property type="term" value="F:serine hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013818">
        <property type="entry name" value="Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000734">
        <property type="entry name" value="TAG_lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610:SF173">
        <property type="entry name" value="LIPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00151">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00821">
        <property type="entry name" value="TAGLIPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024308204" description="Lipase domain-containing protein" evidence="5">
        <location>
            <begin position="18"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="Lipase" evidence="6">
        <location>
            <begin position="76"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0800006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="341" mass="38252" checksum="AD57B3A9576BF5A7" modified="2020-02-26" version="1">MACKLLVILLFVAGAHSLEPTVGDLPDETLKELDLIHSNKKVAENCTNHKPGTIPQFLLFNRDHRETPIVLSSSNLDQVLPEKETIVLITGWLTSHDTPFFKEMRDAYLERYDCNLIIVDWSKIALLPYTYIHCEVPSIGLRAAKFLCQLSRTVELELNQMHVVGYSFGAQIAGYLGRYVRLQCDQEIGRITALDAAGPLYESAAANKSLTKTDALFVDVIHTTSSFGMWKNCGKVDFHPNCEWRPQPGCRDPSPTDKSAPVADTLCSSLRSVEYMTESIQSTQLIAISCGLCSRYCHPDIISEVYTIMGEECKTIPKPAKNFLIRTRDKRPYGQGMLPYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2024-01-24" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ATI9</accession>
    <name>A0A5N4ATI9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4817 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_06369</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000004">
        <property type="protein sequence ID" value="KAB0800629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ATI9"/>
    <dbReference type="InParanoid" id="A0A5N4ATI9"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032135">
        <property type="entry name" value="DUF4817"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47326:SF1">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47326">
        <property type="entry name" value="TRANSPOSABLE ELEMENT TC3 TRANSPOSASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16087">
        <property type="entry name" value="DUF4817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4817" evidence="1">
        <location>
            <begin position="7"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0800629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="123" mass="14427" checksum="FE28FDBE34E16895" modified="2020-02-26" version="1" fragment="single">MVFSNREGFDMLMVLGECRQNYRAAERLYAERYPQRPVQSRKVFQRLADRVKMTGEVQPKHNKNRRIGRYVQDERAPDILAAVALDPHVSTRRLAIDAGMSQMTAWRILNGNKLYPYHVNLHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AUF6</accession>
    <name>A0A5N4AUF6_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_05300</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000003">
        <property type="protein sequence ID" value="KAB0800946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AUF6"/>
    <dbReference type="FunCoup" id="A0A5N4AUF6">
        <property type="interactions" value="129"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AUF6"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd20520">
        <property type="entry name" value="CYCLIN_CCNE_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000154">
        <property type="entry name" value="Cyclin-B1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048258">
        <property type="entry name" value="Cyclins_cyclin-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00292">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 4" id="KW-0195">Cyclin</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="256"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="7">
        <location>
            <begin position="109"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="8">
        <location>
            <begin position="203"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="378"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="393"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="420"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0800946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="496" mass="56691" checksum="99A4BE1C4078F0F2" modified="2020-02-26" version="1">MAEDGSSGASTSKVQPSSSKRNFDQNTPHSEKHSIYPTGRKRSRMSESGDSWTPSEIRATPLPLLRWADSKDVWQMMVYREEATKHNRICRLFEDPTNFLPRMRAILIDWIMEVCEAYHLTRTTFYLAVDYIDRYLTVNPAVPKNQLQLIGITALFIAAKFEEIYPPKLSEFSYVCDGACSCEDIVQCEISILSALEWDLNFMTPTGWLNLYMQIHCLNENTGKDPNFNFMFPQYSPFAFVRASNLLDLFTLDPNYLLFSYSVIAAAAVYFIYGRTVALKVSGYQWKHIKCCVHFLSVHYKVLADLQDPRLESVVHYSVDSRQLALLEALQAAVPNLTADGYTIQSHLVTMTNFEDSVVFRVQLMGFSIRKFYVPVPASPNEEGGTSPGRDDSIEDEVPTDDEDLNPDEPEANPDENEAGNQEQVKIESEQTNDGDQEQQPTRLALMFEVKNIALPNQEDSCEEYFTDDKKYNFDELLYEIYLYTKRQIAKADSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AWL6</accession>
    <name>A0A5N4AWL6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">sulfite oxidase</fullName>
            <ecNumber evidence="6">1.8.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PPYR_03816</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">1611_PpyrPB1</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Energy metabolism; sulfur metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Sulfur metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the cytochrome b5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.3.1" evidence="6"/>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0801630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AWL6"/>
    <dbReference type="FunCoup" id="A0A5N4AWL6">
        <property type="interactions" value="1174"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AWL6"/>
    <dbReference type="UniPathway" id="UPA00096"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008482">
        <property type="term" value="F:sulfite oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006790">
        <property type="term" value="P:sulfur compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000007">
        <property type="entry name" value="Sulfite oxidase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.420.10:FF:000002">
        <property type="entry name" value="sulfite oxidase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.420.10">
        <property type="entry name" value="Oxidoreductase, molybdopterin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008335">
        <property type="entry name" value="Mopterin_OxRdtase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000572">
        <property type="entry name" value="OxRdtase_Mopterin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036374">
        <property type="entry name" value="OxRdtase_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19372:SF7">
        <property type="entry name" value="SULFITE OXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19372">
        <property type="entry name" value="SULFITE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00174">
        <property type="entry name" value="Oxidored_molyb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00407">
        <property type="entry name" value="EUMOPTERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56524">
        <property type="entry name" value="Oxidoreductase molybdopterin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0349">Heme</keyword>
    <keyword evidence="11 13" id="KW-0408">Iron</keyword>
    <keyword evidence="9 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="14">
        <location>
            <begin position="86"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAB0801630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="456" mass="51425" checksum="1C2B8AAD27DE9229" modified="2020-02-26" version="1">MYKYIRLTNTLRYSGERINNGIRLCCTHEFNSNKHRSRSHTAGLLFGAAVSSLLAYKIYKENKFVYLKEAEKQINTDKYGAYQPNLPEYSLEEVTKHATKSTKIWVIFRRGVYDITSFVEEHPGGDQIMLGAGNSIEPFWLLYGVHNQIQIYEMLEKMRIGNISEKDAGESVKDMSDPYHNDPKRHPILKPASVKPFNAEAPLSLLADNFISPNELFYVRNHLPVPEVDISTYELEVEVEGTKKKLVLSFKDLERLQKHTITATIMCAGNRRSEMSKLKTVKGLDWGCAAIGNATYTGVRLRDVLDKVGIKEGSDYKHVQFEGLDTDSTGKSYGASIPFWRAVDKKCDVLLAYEMNGKPLPKDHGFPIRVVVPGVVGARNVKWLGKIVVSQNESDSHWQQNDYKGFSPSIDWDNVDFSTAPAIQELPVTSAICKPAPGSTVKIEDGCIFVQEFSRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AXK8</accession>
    <name>A0A5N4AXK8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">WD repeat-containing protein 55 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PPYR_04209</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat Groucho/TLE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AXK8"/>
    <dbReference type="InParanoid" id="A0A5N4AXK8"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090090">
        <property type="term" value="P:negative regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000001">
        <property type="entry name" value="transducin-like enhancer protein 3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009146">
        <property type="entry name" value="Groucho_enhance"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10814:SF36">
        <property type="entry name" value="PROTEIN GROUCHO-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10814">
        <property type="entry name" value="TRANSDUCIN-LIKE ENHANCER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01850">
        <property type="entry name" value="GROUCHOFAMLY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="342"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="384"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="466"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="14"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="74"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="92"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="112"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0802023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="542" mass="58073" checksum="88633A9E088A13A8" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AY05</accession>
    <name>A0A5N4AY05_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">LRRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_04349</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AY05"/>
    <dbReference type="InParanoid" id="A0A5N4AY05"/>
    <dbReference type="OrthoDB" id="6765403at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366">
        <property type="entry name" value="IG(IMMUNOGLOBULIN) AND LRR(LEUCINE RICH REPEAT) DOMAINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366:SF96">
        <property type="entry name" value="LEUCINE RICH REPEAT CONTAINING 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024379898" description="LRRCT domain-containing protein" evidence="4">
        <location>
            <begin position="22"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="617"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0802163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="667" mass="76049" checksum="01E06867D4DFA580" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AZW2</accession>
    <name>A0A5N4AZW2_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PPYR_05019</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AZW2"/>
    <dbReference type="FunCoup" id="A0A5N4AZW2">
        <property type="interactions" value="86"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AZW2"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005283">
        <property type="term" value="F:amino acid:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0089718">
        <property type="term" value="P:amino acid import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF323">
        <property type="entry name" value="SODIUM-DEPENDENT TRANSPORTER BEDRAGGLED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0915">Sodium</keyword>
    <keyword evidence="5" id="KW-0769">Symport</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="84"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="204"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="288"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="403"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="443"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="477"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="517"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0802833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="835" mass="92757" checksum="7F65F00FA05C3EC0" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AZX0</accession>
    <name>A0A5N4AZX0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein Abitram</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Actin-binding transcription modulator</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_05078</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABITRAM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AZX0"/>
    <dbReference type="FunCoup" id="A0A5N4AZX0">
        <property type="interactions" value="819"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AZX0"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032433">
        <property type="term" value="C:filopodium tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030027">
        <property type="term" value="C:lamellipodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003785">
        <property type="term" value="F:actin monomer binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048813">
        <property type="term" value="P:dendrite morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051489">
        <property type="term" value="P:regulation of filopodium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039169">
        <property type="entry name" value="Abitram"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033753">
        <property type="entry name" value="GCV_H/Fam206"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13651">
        <property type="entry name" value="PROTEIN ABITRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13651:SF0">
        <property type="entry name" value="PROTEIN ABITRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01597">
        <property type="entry name" value="GCV_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0802892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="176" mass="20028" checksum="FC211ADA1316C55B" modified="2020-02-26" version="1">MIQPDIIDSIDLNSVNAFLPVSDRYYKHKYCIKFSTKEQNLDQKVSFHTNRICMISLAENHPVMKNNKKVAKINCTIDEKINRLLNSTSGKGKRGAQKLMKNSILCYIECEDGDVYPVYSCVQGKLLEINENLISNPNLLVTNPVDKGYIALVLPMLNVYESMKNSMLDADEYSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B0K1</accession>
    <name>A0A5N4B0K1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Peptidase M13 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PPYR_00092</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B0K1"/>
    <dbReference type="InParanoid" id="A0A5N4B0K1"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08662">
        <property type="entry name" value="M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF224">
        <property type="entry name" value="NEPRILYSIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00786">
        <property type="entry name" value="NEPRILYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="12">
        <location>
            <begin position="756"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="11">
        <location>
            <begin position="1034"/>
            <end position="1239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="536"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="692"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="594"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAB0803122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1241" mass="141150" checksum="0DAB7CB0C97F9DD2" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B0S2</accession>
    <name>A0A5N4B0S2_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH psq-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_00123</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B0S2"/>
    <dbReference type="InParanoid" id="A0A5N4B0S2"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
        <property type="entry name" value="HTH_psq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH psq-type" evidence="2">
        <location>
            <begin position="56"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0803153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="110" mass="12744" checksum="10A22D3597352D7D" modified="2020-02-26" version="1">MKWGISPLSSGVMPHYLSVEMPQQKMLLNANFCCFTDMPTEYKRKCLDRGKWSSQQLSDALEAINNGTMGVNEASRTFQIPSRTLRRRITSKKQPWVLLHCLAEKKKRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2024-07-24" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B0W0</accession>
    <name>A0A5N4B0W0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF659 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_00194</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B0W0"/>
    <dbReference type="InParanoid" id="A0A5N4B0W0"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007021">
        <property type="entry name" value="DUF659"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04937">
        <property type="entry name" value="DUF659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF659" evidence="1">
        <location>
            <begin position="28"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0803224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="409" mass="46114" checksum="C54BA8FC3FCB7450" modified="2020-02-26" version="1">MSANVPLNKLSNPQFKSFLEKYCKKSVPDQSTLRKRYVSECYTETMNNIRQTVQNRFLFFVVDETTDVCGRYIANLMVGVLGESSSNKSFLISCKHIEKTNNETISRFIVEGLSNLFLPKAVPHDKIVLMLSDAAPYMIKAAQNLKIFYPNLIHNTCLAHGVNRVAEEVRNQFPVVNDFINNVKKVFVKAPLRVQLYKEMLPGIPLPPKPILTRWGTWVEAALFYAQHFESIKKVLTELSSEDSSAAISESNQLAANPQLSQQLAYIKNNFSIFPKLFLELEKQDVLLIDAINLIENFKKTMNSLKGKIGKCISKKLNDTLSKNNGYQILKNVSMVLMGDIVEGLEIDPNILSALSNAPITSVDVERSFSAYKLILSDRRQSFLAENLEKHIIVSVNSNITINLNDATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2024-10-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B0Y6</accession>
    <name>A0A5N4B0Y6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">FUN14 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_00229</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FUN14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B0Y6"/>
    <dbReference type="InParanoid" id="A0A5N4B0Y6"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007014">
        <property type="entry name" value="FUN14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21346">
        <property type="entry name" value="FUN14 DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21346:SF0">
        <property type="entry name" value="RE45833P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04930">
        <property type="entry name" value="FUN14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0803259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="148" mass="16738" checksum="20F5877470F5A88C" modified="2020-02-26" version="1">MTHSSKSLLNMLLETVEKISLSKQILYGTFSGWIASYGLMKVGKTAALVIGGGIVLIEIASENGYVNINWNKINMRIEELAENRHQEDGEYWVDIVEQCIDINNERKKFEQKSVQRRTVDQDSIQSRRNNIVFLSSIFVGLLIGIGMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B119</accession>
    <name>A0A5N4B119_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7869 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_00226</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B119"/>
    <dbReference type="InParanoid" id="A0A5N4B119"/>
    <dbReference type="OrthoDB" id="434783at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057191">
        <property type="entry name" value="DUF7869"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10773:SF19">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10773">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25273">
        <property type="entry name" value="DUF7869"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7869" evidence="2">
        <location>
            <begin position="505"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0803256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="749" mass="86268" checksum="2BAE191E45847E0E" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B3X8</accession>
    <name>A0A5N4B3X8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Dystroglycan 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="23">Dystroglycan</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">Dystrophin-associated glycoprotein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="29" type="ORF">PPYR_01050</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="29 30" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="29">1611_PpyrPB1</strain>
            <tissue evidence="29">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization.</text>
    </comment>
    <comment type="function">
        <text evidence="20">Transmembrane protein that plays important roles in connecting the extracellular matrix to the cytoskeleton. Acts as a cell adhesion receptor in both muscle and non-muscle tissues. Receptor for both DMD and UTRN and, through these interactions, scaffolds axin to the cytoskeleton. Also functions in cell adhesion-mediated signaling and implicated in cell polarity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <location evidence="1">Sarcolemma</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
            <location evidence="5">Nucleoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="24">Postsynaptic cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="29">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B3X8"/>
    <dbReference type="InParanoid" id="A0A5N4B3X8"/>
    <dbReference type="OrthoDB" id="5990676at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016011">
        <property type="term" value="C:dystroglycan complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042383">
        <property type="term" value="C:sarcolemma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043236">
        <property type="term" value="F:laminin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002009">
        <property type="term" value="P:morphogenesis of an epithelium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021675">
        <property type="term" value="P:nerve development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11305">
        <property type="entry name" value="alpha_DG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1040">
        <property type="entry name" value="Dystroglycan, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027468">
        <property type="entry name" value="Alpha-dystroglycan_domain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041631">
        <property type="entry name" value="Alpha_DG1_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006644">
        <property type="entry name" value="Cadg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008465">
        <property type="entry name" value="DAG1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030398">
        <property type="entry name" value="SEA_DG_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21559:SF21">
        <property type="entry name" value="DYSTROGLYCAN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21559">
        <property type="entry name" value="DYSTROGLYCAN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18424">
        <property type="entry name" value="a_DG1_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05454">
        <property type="entry name" value="DAG1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05345">
        <property type="entry name" value="He_PIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00736">
        <property type="entry name" value="CADG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111006">
        <property type="entry name" value="Dystroglycan, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51699">
        <property type="entry name" value="SEA_DG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="16" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="26" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0964">Secreted</keyword>
    <keyword evidence="11 27" id="KW-0732">Signal</keyword>
    <keyword evidence="13" id="KW-0770">Synapse</keyword>
    <keyword evidence="10 26" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 26" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="27">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024272031" description="Dystroglycan 1" evidence="27">
        <location>
            <begin position="22"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="1142"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S72" evidence="28">
        <location>
            <begin position="731"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S72" evidence="28">
        <location>
            <begin position="986"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="275"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="536"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="1197"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="25">
        <location>
            <begin position="282"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="25">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="25">
        <location>
            <begin position="378"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="25">
        <location>
            <begin position="395"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="25">
        <location>
            <begin position="439"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="25">
        <location>
            <begin position="536"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="25">
        <location>
            <begin position="1259"/>
            <end position="1274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00024991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00026224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00030092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00031034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00034100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS51699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="EMBL" id="KAB0804080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1274" mass="142531" checksum="7692464C440E7C1C" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B485</accession>
    <name>A0A5N4B485_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_01401</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B485"/>
    <dbReference type="InParanoid" id="A0A5N4B485"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SAP" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="SWIM-type" evidence="3">
        <location>
            <begin position="130"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0804431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="277" mass="31785" checksum="88AB575E3C21C9C4" modified="2020-02-26" version="1">MNISDLKSALKQLGAKTSGSKQQLEKRLSTWKEHGLEKTLFEVDLMKCVPSEEFPTSALFKPLNTYSGTALISYDAIHKWFSDRRALKGMQKGRILAIKLFIKYSKTYIDGNKYYLQCKCCAEQRKTFEYNVKIKVVQHQSTFEIAQCQCTCPAGTGWSAACKHIGAFCFSLEYFSISGNTQEYVSCTSQPMEWNKPIVGRGIDVMSIFEITGRQRNSYTIRESDPLVNNLINNNISCPLTNKRKANLEGYTNDHFGLVHMGRYLINIFKYVYRRIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B4B7</accession>
    <name>A0A5N4B4B7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BESS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_01431</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B4B7"/>
    <dbReference type="InParanoid" id="A0A5N4B4B7"/>
    <dbReference type="OrthoDB" id="6781616at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0804461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="205" mass="23055" checksum="C4BD08F343D958E0" modified="2020-02-26" version="1">MDKNKCRKSVSSTKKMIHSQIEDSEVIDDNEVVAEEVYNENSEPIGERTEPELNPKKALEEEPLPSTSATSTNELPNSQLQKAKRAKRNKENSNVPNEDPRISAVVDIMRSAQDRDSCDIYGEHIASKLRTYSQRTQAMVQHMFSNILFNADMGRYDDVVPKNTSGHLSSSGSVTSASTCTNYPCSFTCWFKLSLFRSCFTVPYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B4Z0</accession>
    <name>A0A5N4B4Z0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_01400</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B4Z0"/>
    <dbReference type="InParanoid" id="A0A5N4B4Z0"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF74">
        <property type="entry name" value="POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="3">
        <location>
            <begin position="58"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="578"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0804430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="693" mass="77687" checksum="F8467E39DD21E4FB" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B4Z9</accession>
    <name>A0A5N4B4Z9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF659 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_01410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B4Z9"/>
    <dbReference type="InParanoid" id="A0A5N4B4Z9"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0804440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="102" mass="11903" checksum="BD593D7F9979021E" modified="2020-02-26" version="1">MDLCTALIAANIPWYKLDNPQFRQFLEKCSSTNIPDRTTLSKLYLPKCYNQAISDIRADIGHYNVWICVDETTDSMGRFNVNILKKSLNIITLMKRSFWQHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B5U8</accession>
    <name>A0A5N4B5U8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Chitin-binding type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_01700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B5U8"/>
    <dbReference type="InParanoid" id="A0A5N4B5U8"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052976">
        <property type="entry name" value="Scoloptoxin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22933">
        <property type="entry name" value="FI18007P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22933:SF43">
        <property type="entry name" value="LP10131P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chitin-binding type-2" evidence="1">
        <location>
            <begin position="45"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0804730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="127" mass="14963" checksum="CAADBF8CCDF05FEE" modified="2020-02-26" version="1">MYRLSGISLPSNDACVKHRIMVGYSAVHAQEKFTESYRFENMTFTFDCSNRAVGFYADPEYDCQIFHMCNGDGKRIPHVCANETSFNQEFRICDWEYNFDCSQAEKWYYLNELTYMTDSSQDEDIVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B5Z9</accession>
    <name>A0A5N4B5Z9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UDP-glucuronosyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PPYR_01956</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:132367"/>
            <dbReference type="ChEBI" id="CHEBI:132368"/>
            <dbReference type="EC" id="2.4.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Membrane</location>
            <topology evidence="5">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.17" evidence="5"/>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B5Z9"/>
    <dbReference type="InParanoid" id="A0A5N4B5Z9"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015020">
        <property type="term" value="F:glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000050">
        <property type="entry name" value="UDP-glucuronosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035595">
        <property type="entry name" value="UDP_glycos_trans_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF159">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00375">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024500908" description="UDP-glucuronosyltransferase" evidence="5">
        <location>
            <begin position="19"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="469"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0804986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="517" mass="59081" checksum="E0DFC39100AAA3A8" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B6P6</accession>
    <name>A0A5N4B6P6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">ZZ-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PPYR_02251</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">1611_PpyrPB1</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <location evidence="2">Sarcolemma</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0805281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B6P6"/>
    <dbReference type="FunCoup" id="A0A5N4B6P6">
        <property type="interactions" value="118"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4B6P6"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016010">
        <property type="term" value="C:dystrophin-associated glycoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042383">
        <property type="term" value="C:sarcolemma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050804">
        <property type="term" value="P:modulation of chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046716">
        <property type="term" value="P:muscle cell cellular homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099536">
        <property type="term" value="P:synaptic signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015153">
        <property type="entry name" value="EF-hand_dom_typ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015154">
        <property type="entry name" value="EF-hand_dom_typ2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050774">
        <property type="entry name" value="KCMF1/Dystrophin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12268:SF14">
        <property type="entry name" value="DYSTROPHIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12268">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE KCMF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09068">
        <property type="entry name" value="EF-hand_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09069">
        <property type="entry name" value="EF-hand_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00569">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50135">
        <property type="entry name" value="ZF_ZZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="WW" evidence="13">
        <location>
            <begin position="7"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="ZZ-type" evidence="14">
        <location>
            <begin position="256"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAB0805281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="632" mass="71949" checksum="361FC00AE78FCE09" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B7Z8</accession>
    <name>A0A5N4B7Z8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_02623</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0805653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B7Z8"/>
    <dbReference type="FunCoup" id="A0A5N4B7Z8">
        <property type="interactions" value="32"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4B7Z8"/>
    <dbReference type="OrthoDB" id="8825892at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013151">
        <property type="entry name" value="Immunoglobulin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23278">
        <property type="entry name" value="SIDESTEP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23278:SF30">
        <property type="entry name" value="SIDESTEP VIII, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00047">
        <property type="entry name" value="ig"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="676"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="55"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="179"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="271"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="370"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="467"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="706"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="905"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="707"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="722"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="909"/>
            <end position="929"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0805653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="929" mass="104102" checksum="DB29F4A287405C6E" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1JQM1</accession>
    <name>A0A1Y1JQM1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Vesicle tethering protein Uso1/P115-like head domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PPYR_13776</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
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    <reference evidence="8" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
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                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
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        <subcellularLocation>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <location>
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        <location>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="JAV51479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0794156.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="807" mass="90408" checksum="B3A86762106C7B57" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1JTR1</accession>
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            <taxon>Pterygota</taxon>
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            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
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            <taxon>Elateroidea</taxon>
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    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
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                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
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    <reference evidence="7" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
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        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:thiamine binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="thi_PPkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622:SF8">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE 1"/>
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    </dbReference>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
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            <taxon>Coleoptera</taxon>
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            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01097409">
        <property type="protein sequence ID" value="JAV54219.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1JY43"/>
    <dbReference type="InParanoid" id="A0A1Y1JY43"/>
    <dbReference type="OrthoDB" id="6610549at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036029733" description="EB domain-containing protein" evidence="3">
        <location>
            <begin position="22"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="137"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="215"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="JAV54219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0802200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="265" mass="29329" checksum="7F81B9C52ED0DFB2" modified="2017-08-30" version="1">MSKCWLRVILQGLLLLRALLAAEDLTTRHPDMVGRGDKMYDDRCNSTNDCGFWGSVCAAMGRCHCSPEYPISNHLDKCGKSARVNESCTFNEQCEYLNSVTTCRDGLCTCKFDRQPIIHPDGRSECIVIENTSNDEFVAPTMIGILVAMAVMFIIICIVFRLFSNARWRENRTIFNTPNPRLMNVSLLRDSKILHQERRSSRGSIRGPSRPPSMPSLAPHSPGSKGSHGSVDSPRSNKSSPGHINSGSAATTPMLESVTVEVRNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1K6E5</accession>
    <name>A0A1Y1K6E5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Scavenger receptor class B member 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PPYR_11925</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CD36 family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01095929">
        <property type="protein sequence ID" value="JAV55255.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0795086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1K6E5"/>
    <dbReference type="FunCoup" id="A0A1Y1K6E5">
        <property type="interactions" value="269"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1K6E5"/>
    <dbReference type="OrthoDB" id="514335at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005044">
        <property type="term" value="F:scavenger receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002159">
        <property type="entry name" value="CD36_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11923:SF93">
        <property type="entry name" value="GH07959P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11923">
        <property type="entry name" value="SCAVENGER RECEPTOR CLASS B TYPE-1 SR-B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01130">
        <property type="entry name" value="CD36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01609">
        <property type="entry name" value="CD36FAMILY"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="440"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="JAV55255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0795086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="507" mass="58209" checksum="4D846F8FD9F57C5A" modified="2017-08-30" version="1">MRPFSQRLRTMTCYGLIGTFLFTSGVLLLLLWSWLLDVLTASMLVLKPDGALFEVWRKPPMTLALDFYFFNWTNPEEINSKKPKFTEMGPYRFTELREKVNLVWNENDTITYQQLRRWNFDAEFSSGRLTDSVTTLNAVTMSAAHHIKDWNYFMKRGFSHTLSAVAPNAHIVKTVGELLFDGYDDPLVDIAATFPFLSTGIPSFDKFGWFYTRNNSDTFDGVFNMGTGVQGDFGQLKTWNYENETNYYSGECAKVHGSGAEFYTKPLKKDYIGFFSPDMCRYVQLDYEEDKSLSGISGYKYSAQAGMLDNGTLRPENECFCNGDCVPSGMLNVSSCRYGTPAFVSLPHFYGADPTYLSRVEGLHPEKDKHEMYITLEPTTTAPLDVAIRLQLNIRTTPIDYITLYEEIPEIFFPMLWFEQVVSIPDHFKWGLWILSHAEIIFPITGGLITISGAAMIAYVTIRWVTEDIQRRKLKIRTICREEVPLNQSACERSLKRKLNYLDIIYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1K8H2</accession>
    <name>A0A1Y1K8H2_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Homogentisate 1,2-dioxygenase</fullName>
            <ecNumber evidence="5">1.13.11.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Homogentisate oxygenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Homogentisic acid oxidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Homogentisicase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">PPYR_12671</name>
        <name evidence="23" type="ORF">PPYR_12684</name>
    </gene>
    <organism evidence="21">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="22 24" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">1611_PpyrPB1</strain>
            <tissue evidence="22">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">1611_PpyrPB1</strain>
            <tissue evidence="22">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>homogentisate + O2 = 4-maleylacetoacetate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15449"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16169"/>
            <dbReference type="ChEBI" id="CHEBI:17105"/>
            <dbReference type="EC" id="1.13.11.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 17">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 4/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the homogentisate dioxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.5" evidence="5"/>
    <dbReference type="EMBL" id="GEZM01094000">
        <property type="protein sequence ID" value="JAV56015.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1K8H2"/>
    <dbReference type="FunCoup" id="A0A1Y1K8H2">
        <property type="interactions" value="66"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1K8H2"/>
    <dbReference type="OrthoDB" id="1689029at2759"/>
    <dbReference type="UniPathway" id="UPA00139">
        <property type="reaction ID" value="UER00339"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004411">
        <property type="term" value="F:homogentisate 1,2-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:L-tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07000">
        <property type="entry name" value="cupin_HGO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000026">
        <property type="entry name" value="Homogentisate 1,2-dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046451">
        <property type="entry name" value="HgmA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046452">
        <property type="entry name" value="HgmA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005708">
        <property type="entry name" value="Homogentis_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01015">
        <property type="entry name" value="hmgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11056">
        <property type="entry name" value="HOMOGENTISATE 1,2-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11056:SF0">
        <property type="entry name" value="HOMOGENTISATE 1,2-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04209">
        <property type="entry name" value="HgmA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20510">
        <property type="entry name" value="HgmA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="11 17" id="KW-0408">Iron</keyword>
    <keyword evidence="7 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="domain" description="Homogentisate 1,2-dioxygenase N-terminal" evidence="20">
        <location>
            <begin position="5"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="Homogentisate 1,2-dioxygenase C-terminal" evidence="19">
        <location>
            <begin position="278"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="16">
        <location>
            <position position="289"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="338"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="347"/>
        </location>
        <ligand>
            <name>homogentisate</name>
            <dbReference type="ChEBI" id="CHEBI:16169"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="368"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="368"/>
        </location>
        <ligand>
            <name>homogentisate</name>
            <dbReference type="ChEBI" id="CHEBI:16169"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018757"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022878"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00030235"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00030437"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00033225"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR605708-1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR605708-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF04209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF20510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="JAV56015.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAB0793051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KAB0793064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="436" mass="49847" checksum="DCCC461B54532742" modified="2017-08-30" version="1">MDDLKYMSGFGSEFKSEDPRCPQSLPKGQNSPQKCPYGLYAEQLSGTAFTAPRLENRRSWFYRIRPSIGHDPFKPFSNSNVRCNWDQQEPDPNQMRWMPFDLPKSNEKRDFVEGLNTICGSGEIKGKNGLAIHVYVCNVSMNNRAFYNADGDFLIVPQKGTLKVTTEFGKLQVRPNEIVVIQQGMRFSIDIDEPSRGYILEVFGRHFCLPDLGPIGANGLANARDFLTPVAWYEDRDVQYEIIGKYQGKLFVCNQDHSPFDVVAWFGNYVPYKYDLANFMVINSVTFDHCDPSIFTLLTCQSEMKGTAIADFVIFPPRWSVQEHTFRPPYYHRNCMSEFMGLIFGNYEAKAEGFQPGGATLHSTMTPHGPDAQCFEMAFNEELKPKRVAEGTMAFMFETCMELAVTEWGAKTCQKLDLEYYKCWKNIKKHFTGPAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1KE78</accession>
    <name>A0A1Y1KE78_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosomal protein eL8/eL30/eS12/Gadd45 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_01682</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GADD45 family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01087520">
        <property type="protein sequence ID" value="JAV58651.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="interactions" value="362"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="FI09246P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10411">
        <property type="entry name" value="GROWTH ARREST AND DNA DAMAGE-INDUCIBLE PROTEIN GADD45"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="2">
        <location>
            <begin position="23"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="JAV58651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0804712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="164" mass="18095" checksum="4D379028323BD7F0" modified="2017-08-30" version="1">MCISKVQHPKCKMLNRNTIVGEVTGVLTRARVERRLICGLLPAITFLEDNPDGALLCMLSQTRPGDAATHIQTVLLQAFCYENFIPVIQVDSSEKLADLCGLSEGKGRNSECFCAIITTDTNNELNPDEDPPLSPSEQKLADFYECTLEEYPRPVIHLPSLGTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1KK05</accession>
    <name>A0A1Y1KK05_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mediator of RNA polymerase II transcription subunit 22</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Mediator complex subunit 22</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PPYR_03851</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 22 family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01086153">
        <property type="protein sequence ID" value="JAV59734.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01086152">
        <property type="protein sequence ID" value="JAV59736.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0801665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1KK05"/>
    <dbReference type="FunCoup" id="A0A1Y1KK05">
        <property type="interactions" value="1530"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1KK05"/>
    <dbReference type="OrthoDB" id="203279at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009332">
        <property type="entry name" value="Med22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12434">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12434:SF6">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06179">
        <property type="entry name" value="Med22"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="JAV59736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0801665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="140" mass="16309" checksum="3CC073AB0AD772A3" modified="2017-08-30" version="1">MTTPRGLPQSKEALLKSYRTRLKDDVKSMLENFEEIVKLAKGEHDTQLSRMTQCEQDTYEMHVRAANIVRAGESLMKLVSDIKQYLILNDFPSVNEAITQNSKLFRTKQAECDQKLMSLRDDMAADLYDLEEEYYNSIYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1KM25</accession>
    <name>A0A1Y1KM25_PHOPY</name>
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        <recommendedName>
            <fullName evidence="2">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_06934</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01079786">
        <property type="protein sequence ID" value="JAV62374.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KAB0799054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="OrthoDB" id="67516at2759"/>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="PANTHER" id="PTHR45960">
        <property type="entry name" value="GRB2-ASSOCIATED-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45960:SF2">
        <property type="entry name" value="PROTEIN DAUGHTER OF SEVENLESS"/>
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    </dbReference>
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    </feature>
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        </location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="489"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="JAV62374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0799054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="622" mass="70307" checksum="EB361AEB7E0616F8" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1KSY4</accession>
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        <recommendedName>
            <fullName evidence="5 6">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="8" type="ORF">PPYR_14048</name>
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    <organism evidence="7">
        <name type="scientific">Photinus pyralis</name>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
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            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
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            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
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                <person name="Al-Wathiqui N."/>
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                <person name="Lewis S.M."/>
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            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the GMC oxidoreductase family.</text>
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        <property type="protein sequence ID" value="JAV62524.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01079075">
        <property type="protein sequence ID" value="JAV62526.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000010">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="InParanoid" id="A0A1Y1KSY4"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <dbReference type="InterPro" id="IPR007867">
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    <dbReference type="PANTHER" id="PTHR11552:SF158">
        <property type="entry name" value="GH23626P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="5">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="310"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="544"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="588"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="148"/>
            <end position="151"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
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    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="JAV62526.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0792087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="620" mass="69894" checksum="B3F1189857854293" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1L240</accession>
    <name>A0A1Y1L240_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA-directed RNA polymerase II subunit RPB3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PPYR_08498</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01066656">
        <property type="protein sequence ID" value="JAV67743.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1L240"/>
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    </dbReference>
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    <dbReference type="OrthoDB" id="270173at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07031">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.120.12:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB3"/>
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    </dbReference>
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        <property type="entry name" value="DNA-directed RNA polymerase, insert domain"/>
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    </dbReference>
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        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA-dir_RNA_pol_30-40kDasu_CS"/>
    </dbReference>
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        <property type="entry name" value="DNA-dir_RNA_pol_insert"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RNAP_Rpo3/Rpb3/RPAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036643">
        <property type="entry name" value="RNApol_insert_sf"/>
    </dbReference>
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        <property type="entry name" value="Rpo3/RPB3_RNA_Pol_subunit"/>
    </dbReference>
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        <property type="entry name" value="PRK00783.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800:SF2">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01000">
        <property type="entry name" value="RNA_pol_A_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01193">
        <property type="entry name" value="RNA_pol_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00662">
        <property type="entry name" value="RPOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56553">
        <property type="entry name" value="Insert subdomain of RNA polymerase alpha subunit"/>
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    </dbReference>
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        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
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    </dbReference>
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        <property type="entry name" value="RNA_POL_D_30KD"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-0804">Transcription</keyword>
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        <location>
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        </location>
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        <location>
            <begin position="116"/>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00025804"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00072506"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="JAV67743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0797505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="274" mass="31379" checksum="6BB291E54168A1FA" modified="2017-08-30" version="1">MPYANQPSVHITDLTDENVKFYIEDTELSVANSMRRVFIAETPTLAIDWVKLEANSTVLSDEFLAHRIGLIPLISDEVVQRLHYPRDCICPDFCHNCSVEFTLDVKCTDDQTRHVTTADLKSSDPRVLPVTSKHRDDDSSEYGETDEILLIKLRKGQELKMRAYAKKGFGKEHAKWNPTAGVCFEYDPDNAMRHTLYPKPDEWPKSEYTELDDDQYEATFNWETKPNKFFFNVESSGALKPENIVIMGIAMLKDKLSNLQTQLSHELQTDALAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1L586</accession>
    <name>A0A1Y1L586_PHOPY</name>
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        <recommendedName>
            <fullName evidence="2">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="4" type="ORF">PPYR_02728</name>
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    <organism evidence="3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Pterygota</taxon>
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            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
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            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01068147">
        <property type="protein sequence ID" value="JAV67140.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01068146">
        <property type="protein sequence ID" value="JAV67145.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0790928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1L586"/>
    <dbReference type="FunCoup" id="A0A1Y1L586">
        <property type="interactions" value="778"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1L586"/>
    <dbReference type="OrthoDB" id="20229at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015036">
        <property type="term" value="F:disulfide oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
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    </dbReference>
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        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039101">
        <property type="entry name" value="TMX2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15853">
        <property type="entry name" value="THIOREDOXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15853:SF0">
        <property type="entry name" value="THIOREDOXIN-RELATED TRANSMEMBRANE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="110"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="JAV67145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0790928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="263" mass="30386" checksum="E3C02F91FCC99B94" modified="2017-08-30" version="1">MSLKEDLKQLVKPYYIFNIILSFSYIICRKTPGICNYLFDADECEFDGRETEILFFLIIVIMIRSRKTGSVTMINYLSSSFIYTKVANLILWFYADFIMGIIYAIIFILMGLLLPAPAYSGPDKVIYFHGQNSLEDELVRNKQVTWIITFYTVWNPACVTFAPIFAKLSSDYYLDNLKFGKIDVGRYPEAGVKYRVNDSSLSKQLPTMIVFKEGKEVDRRPLIDGKGKVIKFLFSRENVEAAFDLSNLYESCKADSKKHLKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LIS6</accession>
    <name>A0A1Y1LIS6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Microtubule-associated protein Jupiter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_01906</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01054579">
        <property type="protein sequence ID" value="JAV73549.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1LIS6"/>
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        <property type="interactions" value="119"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="6367565at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="JAV73549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0804936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="168" mass="18340" checksum="64A84842F1B6163E" modified="2017-08-30" version="1">MTTYATYRHIELDKVGYGKKRVRNPPSDIFTVLSSPESSPQSNGTSTPRRSQSHNDSFSRLFGSSGSNTPRKLSLNKHDVTVRNPVTGNGVTSWDQHRSSLSPKIKTERNPVTGEVYTIVSPATTPTKLIQNGFGHQNGFASPLKNRHEGIANELKAPADKPLTNGQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LL53</accession>
    <name>A0A1Y1LL53_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">hydroxymethylbilane synthase</fullName>
            <ecNumber evidence="4">2.5.1.61</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Hydroxymethylbilane synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PPYR_09703</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>dipyrromethane</name>
            <dbReference type="ChEBI" id="CHEBI:60342"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 2/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HMBS family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.61" evidence="4"/>
    <dbReference type="EMBL" id="GEZM01054541">
        <property type="protein sequence ID" value="JAV73568.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="FunCoup" id="A0A1Y1LL53">
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    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1LL53"/>
    <dbReference type="OrthoDB" id="564646at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00319"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:hydroxymethylbilane synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd13645">
        <property type="entry name" value="PBP2_HuPBGD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000005">
        <property type="entry name" value="Porphobilinogen deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000260">
        <property type="entry name" value="Porphobilinogen deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.40">
        <property type="entry name" value="Porphobilinogen deaminase, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00260">
        <property type="entry name" value="Porphobil_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000860">
        <property type="entry name" value="HemC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022419">
        <property type="entry name" value="Porphobilin_deaminase_cofac_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022417">
        <property type="entry name" value="Porphobilin_deaminase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022418">
        <property type="entry name" value="Porphobilinogen_deaminase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036803">
        <property type="entry name" value="Porphobilinogen_deaminase_C_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00212">
        <property type="entry name" value="hemC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11557">
        <property type="entry name" value="PORPHOBILINOGEN DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11557:SF0">
        <property type="entry name" value="PORPHOBILINOGEN DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01379">
        <property type="entry name" value="Porphobil_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03900">
        <property type="entry name" value="Porphobil_deamC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00151">
        <property type="entry name" value="PORPHBDMNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54782">
        <property type="entry name" value="Porphobilinogen deaminase (hydroxymethylbilane synthase), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00533">
        <property type="entry name" value="PORPHOBILINOGEN_DEAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Porphobilinogen deaminase N-terminal" evidence="8">
        <location>
            <begin position="12"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Porphobilinogen deaminase C-terminal" evidence="9">
        <location>
            <begin position="236"/>
            <end position="303"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004735"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00005638"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012655"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="JAV73568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0798710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="502" mass="55538" checksum="662EB7388630F123" modified="2017-08-30" version="1">MEQKEASTSSVIRVGSRKSELALIQTRHVISLLKNINPQKEFEIVTMSTLGDKVLDIPLPKIGEKSLFTRELETALITGAVDFVVHSLKDLPTTLPTGMAIGAVLTREDPRDALVLRSDHQHLTLETLPENSVIGTSSLRRTAQLAKKFPHLKVESIRGNLNTRLRKLDELGHFHAIILATAGLNRMGWKQRISKVIEEDELLYAVGQGALAVECRESDENTILLLKPLYDPKTAMQVIAERSFLRTLGGGCSAPVAVTTKLVPSETNKFKMSLTGAVWSLDGKEELIQSDESQIEIRECNRCAVCPFGFKSYDASNIGNISSCTADKCTNTDIECLQQCSFKRPTEETNGNIPKKQKSQNPPAELLNTDFHQYCPLKIPVGLDFMGKCPYLESEFNTVNIYPKRCPIFNKGQVEGMNGDFSKCPFLKEGLLQEVIPDNNNKEKEASASNNSNLYVGLVPHVDIPESSLKEAQQLGTRLAKNLMNQGATEIMSKAQEIIRNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LMA8</accession>
    <name>A0A1Y1LMA8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">U5 small nuclear ribonucleoprotein 40 kDa protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">WD repeat-containing protein 57</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PPYR_11917</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for pre-mRNA splicing as component of the activated spliceosome. Component of the U5 small nuclear ribonucleoprotein (snRNP) complex and the U4/U6-U5 tri-snRNP complex, building blocks of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the pre-catalytic and catalytic spliceosome complexes. Component of the postcatalytic spliceosome P complex. Part of the U5 snRNP complex. Interacts with PRPF8. Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, WDR57, SNRNP40, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39. Component of the minor spliceosome, which splices U12-type introns.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="JAV72137.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
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        <property type="protein sequence ID" value="KAB0795078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="interactions" value="2700"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:catalytic step 2 spliceosome"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:U5 snRNP"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="P:mRNA processing"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:RNA splicing, via transesterification reactions"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Small nuclear ribonucleoprotein U5 subunit 40"/>
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    </dbReference>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
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        <property type="entry name" value="U5_snRNP_Component"/>
    </dbReference>
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        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
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        <property type="entry name" value="WD40_PAC1"/>
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        <property type="entry name" value="WD40_repeat_CS"/>
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        <property type="entry name" value="WD40_repeat_dom_sf"/>
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        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44006">
        <property type="entry name" value="U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 40 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44006:SF1">
        <property type="entry name" value="U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 40 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
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        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
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        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="51"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="94"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="136"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="185"/>
            <end position="219"/>
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    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="220"/>
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    </feature>
    <feature type="repeat" description="WD" evidence="11">
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    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="312"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00057342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00064268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00073554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00075772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="JAV72137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAB0795078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="346" mass="38600" checksum="587FD3916318BBA5" modified="2017-08-30" version="1">MISESKRKADDSALVPVSKKTRNEVAVSRNKALSSTTVARTSNLFAPIMLLEGHEGEIFTLEFHPEGQYLASSGFDRRIFLWSVYGECENLSVMSGHTGAVMELHFSPDGSHIFTASTDHTLGLWDIATGQRVKKYKGHTNFVNSCQGARRGPQTLVSGSDDSTIRLWDTRKRNSVSTISTPYQVTAVTFSDTAEHIYSSGIDNEIKVWDIRKNELLYSMRGHADTVTGISLSPDGSYLLTNAMDNTLRIWDIRPYAPQERCVKVFTGHLHNFEKNLVRCSWSADGSKVSSGSADRYMYIWDTTSRRIIYKLPGHNGSVNDVDFHPNETIIASGSSDKQIYLGEIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LN67</accession>
    <name>A0A1Y1LN67_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PPYR_12942</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GEZM01052603">
        <property type="protein sequence ID" value="JAV74391.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="InParanoid" id="A0A1Y1LN67"/>
    <dbReference type="OrthoDB" id="427030at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000557">
        <property type="entry name" value="zinc finger and SCAN domain-containing protein 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000706">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000110">
        <property type="entry name" value="Zinc finger protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF29">
        <property type="entry name" value="MYONEURIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="79"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="107"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="135"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="163"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="219"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="JAV74391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0793322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="256" mass="29690" checksum="6B5511B0B2A7AB92" modified="2017-08-30" version="1">MFPFSSMFNNLPFYGNDVPLEIAPVNNEPINNEPVNNEIANDEIVNDPPAANEANPQQNVVNRTTTRRARGEYPQVKPQSCNICGRVLSSASSYYVHMKVHSDSKPFQCTSCDASFCRKPYLEAHLRTHTGERPFKCNYCHKRFTQKSSLNTHKRIHTGETPYFCDICEKRFTVKSYVTAHRFTHVNEKPVSCNHCSLPFTSRHQFAAHCKTHITREMFTCTFCGRSFARQSYLIRHHNRLHRYAEVKNEPVNNWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LPI8</accession>
    <name>A0A1Y1LPI8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">6-pyruvoyl tetrahydrobiopterin synthase</fullName>
            <ecNumber evidence="4">4.2.3.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PPYR_09660</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; tetrahydrobiopterin biosynthesis; tetrahydrobiopterin from 7,8-dihydroneopterin triphosphate: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PTPS family.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.12" evidence="4"/>
    <dbReference type="EMBL" id="GEZM01055858">
        <property type="protein sequence ID" value="JAV72907.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1LPI8"/>
    <dbReference type="FunCoup" id="A0A1Y1LPI8">
        <property type="interactions" value="977"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1LPI8"/>
    <dbReference type="OrthoDB" id="14045at2759"/>
    <dbReference type="UniPathway" id="UPA00849">
        <property type="reaction ID" value="UER00819"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003874">
        <property type="term" value="F:6-pyruvoyltetrahydropterin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006729">
        <property type="term" value="P:tetrahydrobiopterin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.10:FF:000003">
        <property type="entry name" value="6-pyruvoyl tetrahydrobiopterin synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.10">
        <property type="entry name" value="6-pyruvoyl tetrahydropterin synthase/QueD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007115">
        <property type="entry name" value="6-PTP_synth/QueD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038418">
        <property type="entry name" value="6-PTP_synth/QueD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022469">
        <property type="entry name" value="PTPS_His_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12589:SF7">
        <property type="entry name" value="6-PYRUVOYL TETRAHYDROBIOPTERIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12589">
        <property type="entry name" value="PYRUVOYL TETRAHYDROBIOPTERIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01242">
        <property type="entry name" value="PTPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55620">
        <property type="entry name" value="Tetrahydrobiopterin biosynthesis enzymes-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00988">
        <property type="entry name" value="PTPS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0783">Tetrahydrobiopterin biosynthesis</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="JAV72907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0798667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="139" mass="16247" checksum="777E1765E8F51262" modified="2017-08-30" version="1">MVHKAYLTRREVFSASHRLHSPKLSDEENLAIYGKCNHPNGHGHNYVVEVTLYGEVNEQTGMVMNITLLKEFMKSAIMDTMDHKNLDVDVAYFHIHPSTAEHVAIYIWQNMRKHMEEPNLLHEVKVFETENNIVRYRGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1M5T3</accession>
    <name>A0A1Y1M5T3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Mediator of RNA polymerase II transcription subunit 20</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 6">Mediator complex subunit 20</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">MED20</name>
        <name evidence="8" type="ORF">PPYR_09701</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the Mediator complex subunit 20 family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01040345">
        <property type="protein sequence ID" value="JAV80891.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01040344">
        <property type="protein sequence ID" value="JAV80892.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1M5T3"/>
    <dbReference type="FunCoup" id="A0A1Y1M5T3">
        <property type="interactions" value="2235"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1M5T3"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013921">
        <property type="entry name" value="Mediator_Med20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12465:SF0">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12465">
        <property type="entry name" value="UBIQUITIN SPECIFIC PROTEASE HOMOLOG 49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08612">
        <property type="entry name" value="Med20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="JAV80891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0798708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="207" mass="23383" checksum="BC60DF1C799ACC20" modified="2017-08-30" version="1">MGVTVLQQFPIVENRTGPLTIDLLTKRISALGATQQGQFLVDCETFTSIQQLGHQRTVHVLHNSEQPATVFSILETGTKTIPLATDGLFDLLMTKMNNFYTAKKQTKVESKGPRFEIGDFLVKLGSVTITQNFKGVLVEVEYKPCVVPAMCWELMREFLQGFLGSSVPNTPPAYLQNRMQEIYTPIDTIHQYLEQFTMYRKSPGMRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1MA14</accession>
    <name>A0A1Y1MA14_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Aminopeptidase</fullName>
            <ecNumber evidence="12">3.4.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PPYR_05936</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">1611_PpyrPB1</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">1611_PpyrPB1</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="11 12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11 12">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-" evidence="12"/>
    <dbReference type="EMBL" id="GEZM01036661">
        <property type="protein sequence ID" value="JAV82534.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000004">
        <property type="protein sequence ID" value="KAB0800196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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            <begin position="1"/>
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        <location>
            <position position="355"/>
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        <ligand>
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        <source>
            <dbReference type="EMBL" id="KAB0800196.1"/>
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        <source>
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    </evidence>
    <sequence length="945" mass="108419" checksum="E62585C2AFB62785" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1MDA6</accession>
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        <recommendedName>
            <fullName evidence="9">Nicalin</fullName>
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        <name evidence="13" type="ORF">PPYR_01907</name>
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        <name type="scientific">Photinus pyralis</name>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
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            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
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            <taxon>Photinus</taxon>
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    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
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                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
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        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
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        </source>
    </reference>
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        <text evidence="2 9">Belongs to the nicastrin family.</text>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="InterPro"/>
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        <source>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
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    </evidence>
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        <source>
            <dbReference type="PIRNR" id="PIRNR011018"/>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF04389"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="JAV82580.1"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAB0804937.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="551" mass="61878" checksum="EA7765A371C37626" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1MDH2</accession>
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        <recommendedName>
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        <name evidence="3" type="ORF">PPYR_05974</name>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
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                <person name="Al-Wathiqui N."/>
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                <person name="South A."/>
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                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
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            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
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    <reference evidence="3" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01034203">
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        <property type="molecule type" value="Transcribed_RNA"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245:SF11">
        <property type="entry name" value="LD23561P"/>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="6"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="JAV83869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0800234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="367" mass="41069" checksum="8F38233AA383D0AD" modified="2017-08-30" version="1">MEKPTILILGGCGFIGRNLVAYLVSNNLVKFVRIVDKVPPQVAWLNSAHQEVFNNPIIEYKSANLINLDSCKNAFSPSSEVHTWDYVINCAGETKPAQTDPVYKEGILKLSLNCANQAALHKAKRYIEISSGQMFNADKVAHKEDDAIKPWTFIAKWKRQVETELEQIPDLRYTIVRPAITYGLGDKAGLMPRLMVAAIYKQLGETMKLLWSSDLKLSTVHVNDICRAIWFLCRRDDTVGQIYNVADDAESTQGSICGLLTDILDVKVDYYGNLVSSAVDLTAAADDANDKHLKPWAEACRKDAVQNTPLSPHMDYEILLPKNLHLDCSKIKKLGFEVSIPKPTVENLQEIVRDYVDMKVFPNSLAS</sequence>
</entry>
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    <accession>A0A1Y1MRT5</accession>
    <name>A0A1Y1MRT5_PHOPY</name>
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            <fullName evidence="3">Mediator of RNA polymerase II transcription subunit 29</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Mediator complex subunit 29</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Protein intersex</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PPYR_09797</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 29 family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01023373">
        <property type="protein sequence ID" value="JAV88421.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01023371">
        <property type="protein sequence ID" value="JAV88422.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0795736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A1Y1MRT5"/>
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    <dbReference type="OrthoDB" id="6366949at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021018">
        <property type="entry name" value="Mediator_Med29_met"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28314">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28314:SF1">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 29"/>
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    <dbReference type="Pfam" id="PF11568">
        <property type="entry name" value="Med29"/>
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        <location>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00019684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="JAV88422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAB0795736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="161" mass="17693" checksum="32C9C40ACCAB4945" modified="2017-08-30" version="1">MNVPGIGLPPQNPQQQQQQPPQPLDNISKIKTLIGPLRESLSNTIKTAAQTLNQNSQVDVGSLKGVDVQIPRFDKCLEEFYSICDQVELHLKTSIKCLSQGESGNRYLQLPVAPTRNENLGIPDNTLTYPQFLSTVNSQIAFTKEIHDTLVAAAQNISPSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1MTD4</accession>
    <name>A0A1Y1MTD4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein THEM6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_06847</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
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            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
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            <taxon>Elateroidea</taxon>
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            <taxon>Lampyrinae</taxon>
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    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
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                <person name="Fallon T.R."/>
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                <person name="Weng J.K."/>
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            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the THEM6 family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01023404">
        <property type="protein sequence ID" value="JAV88408.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0798967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1MTD4"/>
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    <dbReference type="InParanoid" id="A0A1Y1MTD4"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="CDD" id="cd00586">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051490">
        <property type="entry name" value="THEM6_lcsJ_thioesterase"/>
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    <dbReference type="PANTHER" id="PTHR12475">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12475:SF11">
        <property type="entry name" value="PROTEIN THEM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13279">
        <property type="entry name" value="4HBT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00041112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="JAV88408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0798967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="219" mass="25401" checksum="D75CA7D7DC466000" modified="2017-08-30" version="1">MFCDIVAVILVLIVLLHLCLEVHYFLRISLSVIMARLCKPKISILQETTVQGICLTTDVDTFLYHMNNARFIRELDFARADFYERTGLFQCIRNKKGAFALGATTMRYRRFLRLFQRYIIKTKVVYWNEQDVFMEHRFVNLHDNFVNAIALVKIRFLNCTVADVMKELLEKTGVDASQVKPKLPLEVAKWIESNEISSTILRTENSPNNVTINVSSTDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1N820</accession>
    <name>A0A1Y1N820_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">LRRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PPYR_03735</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01010359">
        <property type="protein sequence ID" value="JAV94082.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1N820"/>
    <dbReference type="InParanoid" id="A0A1Y1N820"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001164">
        <property type="entry name" value="GH01279p"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050328">
        <property type="entry name" value="Dev_Immune_Receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373:SF398">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING G-PROTEIN COUPLED RECEPTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373">
        <property type="entry name" value="SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="23"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036029911" description="LRRCT domain-containing protein" evidence="4">
        <location>
            <begin position="19"/>
            <end position="812"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="JAV94082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0791935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="812" mass="91492" checksum="6E0DF1C18DD1AD98" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1NB45</accession>
    <name>A0A1Y1NB45_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosome maturation protein SBDS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PPYR_00283</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Associates with the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SDO1/SBDS family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01012961">
        <property type="protein sequence ID" value="JAV92847.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1NB45"/>
    <dbReference type="FunCoup" id="A0A1Y1NB45">
        <property type="interactions" value="1619"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1NB45"/>
    <dbReference type="OrthoDB" id="10253092at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1250.10:FF:000001">
        <property type="entry name" value="SBDS, ribosome maturation factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1250.10">
        <property type="entry name" value="Ribosome maturation protein SBDS, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.900">
        <property type="entry name" value="SBDS protein C-terminal domain, subdomain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018023">
        <property type="entry name" value="Ribosome_mat_SBDS_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036786">
        <property type="entry name" value="Ribosome_mat_SBDS_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002140">
        <property type="entry name" value="Sdo1/SBDS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039100">
        <property type="entry name" value="Sdo1/SBDS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018978">
        <property type="entry name" value="SDO1/SBDS_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037188">
        <property type="entry name" value="Sdo1/SBDS_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019783">
        <property type="entry name" value="SDO1/SBDS_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00291">
        <property type="entry name" value="RNA_SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10927">
        <property type="entry name" value="RIBOSOME MATURATION PROTEIN SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10927:SF1">
        <property type="entry name" value="RIBOSOME MATURATION PROTEIN SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09377">
        <property type="entry name" value="SBDS_domain_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01172">
        <property type="entry name" value="SBDS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89895">
        <property type="entry name" value="FYSH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109728">
        <property type="entry name" value="Hypothetical protein AF0491, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01267">
        <property type="entry name" value="UPF0023"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS N-terminal" evidence="9">
        <location>
            <begin position="15"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS central" evidence="10">
        <location>
            <begin position="110"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF09377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="JAV92847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAB0803313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="250" mass="28511" checksum="DFC45C7518C8F282" modified="2017-08-30" version="1">MPKIFTPTNQLRLTNVAVVRLKKTGKRFEIACYRNKVMAWRNNLETDIDEVLQTHTIFANVSKGQFAKKEDVVKAFGDKDETEICKEILTKGELQVSDKERESMFESQFKQIAYEVSTMCVNPTADCPYPPAIIEAAMRDSHYSVKPHHNIKQQALAVIKLLKGFMPIERAQIKLSISFVNKDGEKFTESFGKVKSLRVENEVKTDYSHTYVVLVEPDHFKEIEEIAKKEGCLLDVLSNREMGSSSNCPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1NBI4</accession>
    <name>A0A1Y1NBI4_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PPYR_10491</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GEZM01007196">
        <property type="protein sequence ID" value="JAV95304.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1NBI4"/>
    <dbReference type="FunCoup" id="A0A1Y1NBI4">
        <property type="interactions" value="1919"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1NBI4"/>
    <dbReference type="OrthoDB" id="9890280at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22652">
        <property type="entry name" value="NUCLEOPORIN NUP43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22652:SF0">
        <property type="entry name" value="NUCLEOPORIN NUP43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="JAV95304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0796430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="355" mass="40500" checksum="A5B66E70C4E43BD9" modified="2017-08-30" version="1">MVQNVHGTYISEKINKIRWRPDAFSYSYAFVTGSWDNDSQNSIKLWRFEEGDDMDIFPFTIQSFPFQGDITEIKFINPDFCVASSSIGSLSYLKFTTVHKGDTQITQENRWEKIHKFKNNDNSSCTGFASYNNDIASVGEDGCINLLNVEHKNVIRSLNEADSSCLNCVTFLKHSEILTGNSRGQMKIWDLRSEDVKPCSTFMLSPDQVASTCLTYHPTQRHIVIAGDEEGSLTVWDLRQNTFPVNLLSAHSESVAEIQFHPDHPDQMFSCSFSGELWHWITNKSSFHGGKLLDVSEVEINPWSSTDQAKNKFEVFMLMPKLHKPINSIDLNYNRVLCGCDNEALYLIDNINIYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1NJ41</accession>
    <name>A0A1Y1NJ41_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CBM39 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_07578</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01005511">
        <property type="protein sequence ID" value="JAV96126.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1NJ41"/>
    <dbReference type="InParanoid" id="A0A1Y1NJ41"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2140">
        <property type="entry name" value="Beta-1,3-glucan-recognition protein, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031756">
        <property type="entry name" value="BGBP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043030">
        <property type="entry name" value="BGBP_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15886">
        <property type="entry name" value="CBM39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51969">
        <property type="entry name" value="CBM39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033750404" description="CBM39 domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="CBM39" evidence="2">
        <location>
            <begin position="20"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="JAV96126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0799698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="188" mass="21483" checksum="9675625513DD98BD" modified="2017-08-30" version="1">MICTSTLILFWLHFVIGTAIEKPVPTFEAFRPIGIRVTMPHVDGLTEFFLWGNINVPLEGQDLGSIQLKTYEQTDGQWVIEDMSVKLNPGDTIYYTFFVNINNEVHRYERQQYTVEALVQRVERVQLSTYEDTCLNDVIALKFIEDGMAIIRKGQDGEEKETIVSTRPVAITIEKGRIEFGKSGSKKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N3ZYI8</accession>
    <name>A0A5N3ZYI8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Sodium-coupled monocarboxylate transporter 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PPYR_15560</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01001893">
        <property type="protein sequence ID" value="KAB0790121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N3ZYI8"/>
    <dbReference type="InParanoid" id="A0A5N3ZYI8"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11492">
        <property type="entry name" value="SLC5sbd_NIS-SMVT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051163">
        <property type="entry name" value="Sodium:Solute_Symporter_SSF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00813">
        <property type="entry name" value="sss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985">
        <property type="entry name" value="SODIUM-COUPLED MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985:SF21">
        <property type="entry name" value="SODIUM-DEPENDENT MULTIVITAMIN TRANSPORTER-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="10" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="119"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="184"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="269"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="313"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="400"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="432"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAB0790121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="482" mass="52096" checksum="3B83DD6C1FD3BA55" modified="2020-02-26" version="1" fragment="single">MFATIDYILFAGTIIVSLCIGIYFGFSKKSQTTDEYLLGGREMQVIPISVSLVASYISGLTVLGVPSDVYVYGANTVWVCLSIVIASIVGYFVFIPVILKLQGPTIFEYFELRFDRKLKVMATCMYTLQILLYSPVVAYIPAIAFSQATGINPHVIIPVVCATCVLYTCVGGFKAVIWTDVFQFLGTITSIVAVLIFGIQSVGGIGEVYKKASRGHRLDFNFSMDPTQRDGFWQMAIGFATHWIYNLTLQPAAVQKYLSLPKSGDIKRVMFFQCCGLIVVNVLAVLIGITVYAKYATCDPISTGKVTRVDQILPYFVMDISQTVPVLPGIFIGGVFSAALSTLSSTFNSLAATVYSDLVSLLISKEAKQDKEGRILKLIVITSGAICIGLTFFVDHMGSLLAFVNASIGLIYGIIVGLFALGVIAPVTNSKGAFLGALSSFLVVGTIAGLNQWHSFKGRLGNFAQPISLEGCNAHVNITTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N3ZZW7</accession>
    <name>A0A5N3ZZW7_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_14973</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01001006">
        <property type="protein sequence ID" value="KAB0790615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N3ZZW7"/>
    <dbReference type="InParanoid" id="A0A5N3ZZW7"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36159">
        <property type="entry name" value="PROTEIN CBG23766"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36159:SF1">
        <property type="entry name" value="RETROVIRUS-RELATED POL POLYPROTEIN FROM TRANSPOSON 412-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0790615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="375" mass="43366" checksum="628F538F6EC86FE9" modified="2020-02-26" version="1">MEIQNDYWNLTESVVIDRSTKSYQYNEFKENDISNILANSNYEITIKKGTWKLLSKAYLHVKSKIDPAPRGGVVTVSNNGLNDFSYAILTYENREIERIDNLGVTSTICNLTEFSGDVSDSVASSLCWYMDTSDKADINRFENSVDATQLKASEKIITDILKQNVNFNKGYAERLQLTKDGKILEKFIPLSKVFRFCRDIPKVLNGEIIIRLRKNDYKNILHAVNDLEYGYKITYLSIWIPEVEPSLQIRENLTDLLASNTTTQYGFNYVNGYRSTLQTAIDGTWRITNTQNKVSGIYVVFSKVGRESNYKNSLMIFDNMNMERIYININNKQFPTKPFETNFNPKNLDYMRLYVEFLNAGLKNDMDEGKEIFIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A032</accession>
    <name>A0A5N4A032_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">FLYWCH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_14867</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000899">
        <property type="protein sequence ID" value="KAB0790687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A032"/>
    <dbReference type="InParanoid" id="A0A5N4A032"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018289">
        <property type="entry name" value="MULE_transposase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007588">
        <property type="entry name" value="Znf_FLYWCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861:SF1">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04500">
        <property type="entry name" value="FLYWCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10551">
        <property type="entry name" value="MULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FLYWCH-type" evidence="4">
        <location>
            <begin position="6"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="MULE transposase" evidence="6">
        <location>
            <begin position="130"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransferase type 11" evidence="5">
        <location>
            <begin position="418"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0790687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="651" mass="75175" checksum="67F8736D574E8021" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A096</accession>
    <name>A0A5N4A096_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PPYR_15670</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome c oxidase subunit 6c family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000812">
        <property type="protein sequence ID" value="KAB0790740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A096"/>
    <dbReference type="FunCoup" id="A0A5N4A096">
        <property type="interactions" value="1057"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A096"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006119">
        <property type="term" value="P:oxidative phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd22901">
        <property type="entry name" value="CcO_VIc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.93.10">
        <property type="entry name" value="Mitochondrial cytochrome c oxidase subunit VIc/VIIs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051389">
        <property type="entry name" value="Cytochrome_c_oxidase_VIc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034884">
        <property type="entry name" value="Cytochrome_c_oxidase_VIc/VIIs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037169">
        <property type="entry name" value="Cytochrome_c_oxidase_VIc_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48416">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 6C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48416:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 6C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02937">
        <property type="entry name" value="COX6C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81415">
        <property type="entry name" value="Mitochondrial cytochrome c oxidase subunit VIc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0790740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="96" mass="10611" checksum="101EA31CAEDDDB53" modified="2020-02-26" version="1">MPTPQTSQPAKIGQSGAMCMMMMSGKPQLRGLLQSSIKRNLIIAIGTSIVAGITFKTLVGDARKKKYLEFYKNYDIDKEFNEMRNKGVFSSCAPDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A1U9</accession>
    <name>A0A5N4A1U9_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_03071</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A1U9"/>
    <dbReference type="InParanoid" id="A0A5N4A1U9"/>
    <dbReference type="OrthoDB" id="7457915at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.30">
        <property type="entry name" value="Haemolymph juvenile hormone binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010562">
        <property type="entry name" value="Haemolymph_juvenile_hormone-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038606">
        <property type="entry name" value="To_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008">
        <property type="entry name" value="PROTEIN TAKEOUT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008:SF41">
        <property type="entry name" value="RE70318P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06585">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00700">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024317303" evidence="1">
        <location>
            <begin position="17"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0791271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="246" mass="27934" checksum="C59EC28C0BA593D4" modified="2020-02-26" version="1">MHRFVLVFVFFASVHSQTDILGQLHICKRSDPKLNDCLKSSIKGALKILASGVPSLKIPSIDPIEVERWTIHASDVLPYEQYYENLNLTGYSDIEIEDVYTNVGDEYFSIHLMCSAPKLLVQGDYAYYLVRPTKGEDLSSQGTVEYKYDAHKFFVKFDGDIIKKGGVEYSEIIRTDFSMVRLRSFEMTFQTDHQRIGDKLGELVNGGTRKLATINMGEYEEMYAAAFQRIANAVFASNPSEKLLPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A207</accession>
    <name>A0A5N4A207_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_03098</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A207"/>
    <dbReference type="InParanoid" id="A0A5N4A207"/>
    <dbReference type="OrthoDB" id="2359216at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="entry name" value="R3H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01424">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00393">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="2">
        <location>
            <begin position="161"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="R3H" evidence="3">
        <location>
            <begin position="206"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0791298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="300" mass="33958" checksum="B84D8D27ECFC26A7" modified="2020-02-26" version="1">MNSRFDNHKHYNDRRPFKRKGRHPYKHRPDTTKYGIIHRVRTQTGVRSQIVLVYNPQLYEPISVLNNATQRFKGQIQIQNSGPDPNDKSRSCFSLNVNNERISHGSYLQESTAKKHLYELAIENLRKTCFSILRKTLPRDSPAVTLDSSTSDTNVQPQTAVGGIGAKMMLKMGWAGGGLGAQAQGITDIVQPTQQIERKGFGTHITIPIDKIREILQGYVESDNINGISFSPDFTKEERSVIHSVAQKMNLKSTSYGTGADRRLVIQKKLDPWQLVHKLLEVGGENEQYQLVMPTEFVNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A278</accession>
    <name>A0A5N4A278_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_03201</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A278"/>
    <dbReference type="InParanoid" id="A0A5N4A278"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="413"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="460"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="517"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="105"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="567"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="577"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0791401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="677" mass="76562" checksum="DEF542709BAB9E6B" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A2F4</accession>
    <name>A0A5N4A2F4_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_03310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A2F4"/>
    <dbReference type="InParanoid" id="A0A5N4A2F4"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024324906" evidence="2">
        <location>
            <begin position="21"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="136"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0791510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="154" mass="17795" checksum="1879E569810BA646" modified="2020-02-26" version="1">MKVLKSTFILLLAFILHTTCHPFHPKSDLVHKGHKKIAPKHDPLHVRTDIKKKLRTLTTGKSKLAEEAQARLEVIRKQLQELMERKVPPKSKVSKVAHEVKNVEKKKRWYKLKKDMKRVLSRASIVGESRTKEVETTSSTTEKSVILQPEDLYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A3Q2</accession>
    <name>A0A5N4A3Q2_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_03718</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A3Q2"/>
    <dbReference type="InParanoid" id="A0A5N4A3Q2"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01228">
        <property type="entry name" value="EGGSHELL"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="98"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="188"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0791918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="396" mass="38748" checksum="2DF645D1B8D9EE73" modified="2020-02-26" version="1">MRAFFWGWCLYKKRERCELKRKSEMRIVLCLYFLAVLQLSCQLKKKKHEERFRVHRSCRWVCYPGLGPGPVVPPTPRSTGGTTEVSPTPSEISPMTGSTSPRSSTEPVTSTSESSPTSPTEPGTGSSSNGSSPVSPTEPGTGSSSDGASPASSTESGSSNGSSTTSPTGGETGSTSDTRSTDDRTDPTPRSTTGDGSSPTTSRPRCHKHHGFGIGSLIGGLIGNGGNGKGGAGTGSVDISGGQVGGTGVGVGGTANGGQGGSGTGTGGGVRITSGNGGSGHGGSGWGGPGLGGSKGNGGWGVGGDGNGRTNISGGNIGGTGFGVGGSGNGTGRGGSGSGYGGNVNVNTGNGGPGYGGRGGYHGHGGYGIGIDVRRAKPKGSVKVRNPGNLKQAVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A4N3</accession>
    <name>A0A5N4A4N3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Intraflagellar transport protein 88 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_14245</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A4N3"/>
    <dbReference type="FunCoup" id="A0A5N4A4N3">
        <property type="interactions" value="130"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A4N3"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097546">
        <property type="term" value="C:ciliary base"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097730">
        <property type="term" value="C:non-motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019894">
        <property type="term" value="F:kinesin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042073">
        <property type="term" value="P:intraciliary transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000468">
        <property type="entry name" value="Intraflagellar transport 88 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44117">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 88 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44117:SF1">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 88 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="238"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="489"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="557"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="625"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="726"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="735"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="768"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="823"/>
            <end position="832"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0792286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="838" mass="94458" checksum="56A9827D83205F4D" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A4Y1</accession>
    <name>A0A5N4A4Y1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">ATP-dependent 6-phosphofructokinase</fullName>
            <shortName evidence="15">ATP-PFK</shortName>
            <shortName evidence="15">Phosphofructokinase</shortName>
            <ecNumber evidence="15">2.7.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Phosphohexokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PPYR_14278</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">1611_PpyrPB1</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 15">Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15 16">
            <text>beta-D-fructose 6-phosphate + ATP = beta-D-fructose 1,6-bisphosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="15">Allosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 15 16">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 15">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade "E" sub-subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.11" evidence="15"/>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A4Y1"/>
    <dbReference type="FunCoup" id="A0A5N4A4Y1">
        <property type="interactions" value="752"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A4Y1"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005945">
        <property type="term" value="C:6-phosphofructokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003872">
        <property type="term" value="F:6-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070095">
        <property type="term" value="F:fructose-6-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048029">
        <property type="term" value="F:monosaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061621">
        <property type="term" value="P:canonical glycolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030388">
        <property type="term" value="P:fructose 1,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.460:FF:000001">
        <property type="entry name" value="ATP-dependent 6-phosphofructokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.460:FF:000003">
        <property type="entry name" value="ATP-dependent 6-phosphofructokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.450:FF:000043">
        <property type="entry name" value="ATP-dependent 6-phosphofructokinase, platelet type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.450:FF:000064">
        <property type="entry name" value="Phosphofructokinase, platelet b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.450">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.460">
        <property type="entry name" value="Phosphofructokinase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03184">
        <property type="entry name" value="Phosphofructokinase_I_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009161">
        <property type="entry name" value="6-Pfructokinase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022953">
        <property type="entry name" value="ATP_PFK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015912">
        <property type="entry name" value="Phosphofructokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000023">
        <property type="entry name" value="Phosphofructokinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035966">
        <property type="entry name" value="PKF_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02478">
        <property type="entry name" value="6PF1K_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13697:SF4">
        <property type="entry name" value="ATP-DEPENDENT 6-PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13697">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00365">
        <property type="entry name" value="PFK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000533">
        <property type="entry name" value="ATP_PFK_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00476">
        <property type="entry name" value="PHFRCTKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53784">
        <property type="entry name" value="Phosphofructokinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00433">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 15" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="11 15 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13 15 16" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="10 15 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="12 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 15 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 15 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphofructokinase" evidence="17">
        <location>
            <begin position="20"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphofructokinase" evidence="17">
        <location>
            <begin position="412"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal catalytic PFK domain 1" evidence="15">
        <location>
            <begin position="1"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal regulatory PFK domain 2" evidence="15">
        <location>
            <begin position="411"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="90"/>
            <end position="91"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="120"/>
            <end position="123"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15">
        <location>
            <begin position="166"/>
            <end position="168"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15">
        <location>
            <begin position="210"/>
            <end position="212"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15">
        <location>
            <begin position="300"/>
            <end position="303"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15">
        <location>
            <position position="480"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15">
        <location>
            <begin position="537"/>
            <end position="541"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="575"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15">
        <location>
            <begin position="582"/>
            <end position="584"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15">
        <location>
            <position position="638"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="664"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15">
        <location>
            <begin position="670"/>
            <end position="673"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15">
        <location>
            <position position="745"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR000533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAB0792319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="788" mass="86617" checksum="7732E9AA23F24DAD" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A5D6</accession>
    <name>A0A5N4A5D6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_14492</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A5D6"/>
    <dbReference type="InParanoid" id="A0A5N4A5D6"/>
    <dbReference type="OrthoDB" id="3800936at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12249">
        <property type="entry name" value="RRM1_hnRNPR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000022">
        <property type="entry name" value="APOBEC1 complementation factor isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21245">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="56"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="136"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="230"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0792533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="385" mass="44079" checksum="CD82F22B63CF9DDD" modified="2020-02-26" version="1">MLTLPQLQRSKATPETIRYRNLLNFIEMNDLETVQFNGQRVTTPRKMKMSAPERGSEIFVGKIPRNIFEDELVPLFGRVGVITKFRLMLDFCGLNRGYAFVTYANAAYADRAVAMLDRYEIRCNRFIGVYKSIDNCRLFMGGVPVDKTKEEIYNVLKEYVDGITKVIMYPAQVLGDVNRGYIFIEFVDHKAAAMARRQLGYGFALWNKDIAIDWADPIPEVSSEIMSQVTKLYIRNLPLQYNESIIRALLRKIIDDAAITKIHQIKDYAFIHFFNRESAEFAMTMLKNTAILGEEVEVDWARPAKYSKFQRMNAPAQNFCTSVPPRMRKIVQERKLSLSRETAALRSPSGTDSPGENSSLCDGTFQLWNTEPLIDTALLSMHISD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A5P8</accession>
    <name>A0A5N4A5P8_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_14548</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A5P8"/>
    <dbReference type="InParanoid" id="A0A5N4A5P8"/>
    <dbReference type="OrthoDB" id="8190514at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007623">
        <property type="term" value="P:circadian rhythm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.15.10.30:FF:000001">
        <property type="entry name" value="Takeout-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.30">
        <property type="entry name" value="Haemolymph juvenile hormone binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010562">
        <property type="entry name" value="Haemolymph_juvenile_hormone-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038606">
        <property type="entry name" value="To_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008:SF18">
        <property type="entry name" value="BCDNA.GH05536-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008">
        <property type="entry name" value="PROTEIN TAKEOUT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06585">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00700">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0090">Biological rhythms</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024350086" evidence="4">
        <location>
            <begin position="17"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00060902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0792589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="242" mass="26937" checksum="26278AD7B16CF0A7" modified="2020-02-26" version="1">MMKTFLMGLLVAYVAAVDLPPNFPICKRQDPKLGECVRAATVEVALMFLKGIPELKLGKALPLKIERMSVEEGYGIVQVVQHYRNVEINGIDLLTVQRADVTATDDSLNLTLTCYGSELRLEADYDVDGHVLILPVVGNGRCTITLINATVTLEMYGVVEGGYLQIRALKITLQPKLVKLRYDNLFGGDPRMGEEINHILNENWSDLFHDVKHGYEEAIAQAIGQVVQALFKQVPYDKLLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A676</accession>
    <name>A0A5N4A676_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Multidrug resistance-associated protein lethal(2)03659</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PPYR_14786</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A676"/>
    <dbReference type="InParanoid" id="A0A5N4A676"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000973">
        <property type="entry name" value="Multidrug resistance-associated protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000026">
        <property type="entry name" value="Multidrug resistance-associated protein lethal(2)03659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000014">
        <property type="entry name" value="Multidrug resistance-associated protein member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000163">
        <property type="entry name" value="Multidrug resistance-associated protein member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF448">
        <property type="entry name" value="FI20146P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="241"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="323"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="695"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="735"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="823"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="920"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="946"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="101"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="406"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="696"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="1011"/>
            <end position="1243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAB0792827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1269" mass="141894" checksum="96B09C744784E99C" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A6S2</accession>
    <name>A0A5N4A6S2_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">ADP/ATP translocase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">ADP,ATP carrier protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PPYR_12578</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">1611_PpyrPB1</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell. Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane.</text>
    </comment>
    <comment type="function">
        <text evidence="16">Catalyzes the exchange of ADP and ATP across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ADP(in) + ATP(out) = ADP(out) + ATP(in)</text>
            <dbReference type="Rhea" id="RHEA:34999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:35000"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 16">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Membrane</location>
            <topology evidence="16">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0792958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A6S2"/>
    <dbReference type="InParanoid" id="A0A5N4A6S2"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005471">
        <property type="term" value="F:ATP:ADP antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140021">
        <property type="term" value="P:mitochondrial ADP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990544">
        <property type="term" value="P:mitochondrial ATP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002113">
        <property type="entry name" value="ADT_euk_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635">
        <property type="entry name" value="ADP,ATP CARRIER PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635:SF14">
        <property type="entry name" value="ADP_ATP TRANSLOCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00927">
        <property type="entry name" value="ADPTRNSLCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0050">Antiport</keyword>
    <keyword evidence="11 14 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="35"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="136"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="241"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU368008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAB0792958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="337" mass="37711" checksum="72309CFB91700070" modified="2020-02-26" version="1">MTVKNVTSDSLHSDFGQKFQNCHVQISMSNSNELRTFAISFMVGGLSGALVKSLTSPLDRVKVILQTQDVAAQFGEGKRKRYTGVIDCFRRIPKEQGFTSLWRGNIVNTVRYFPSQALNFSFNTWYKERINAAFGAGPLAHFASGALAGVTTVTLLYPLEFCQTRISADVGNDAKDRAKRTDFVEREFRGVSDCISKVTKTEGFHVLYRGYFVAVTGVALYRSFYFGMHGYWKEINKGAELSLMVQLIAAQVITITSGMISYPLDTIGRILMMDVGKPKNEKKLDTVRGVVNLVYRERGVAGFYKVNKGTTVNYLRSISGSMILVLYDQCMRYLNAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-09-13" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A733</accession>
    <name>A0A5N4A733_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_12743</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A733"/>
    <dbReference type="InParanoid" id="A0A5N4A733"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024348891" description="WAP domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0793123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="154" mass="17269" checksum="21F4D9B62B122D2A" modified="2020-02-26" version="1">MRGSGILCFLVLVVPAHLFIICQIACPQYQQPCGMPYNCGGCCNYYPPLPPPRPYPIIYPGPFYPVPYPPVTRPSIVVKPTPKPQGPVTVVVNTSTSTKEWHCPEDNDDEDYRSSLGELVECEFDTDCKTFSVRHKCCYHYILETHICKPAVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A7G8</accession>
    <name>A0A5N4A7G8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_12849</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A7G8"/>
    <dbReference type="InParanoid" id="A0A5N4A7G8"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048366">
        <property type="entry name" value="TNP-like_GBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048367">
        <property type="entry name" value="TNP-like_RNaseH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048365">
        <property type="entry name" value="TNP-like_RNaseH_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21788">
        <property type="entry name" value="TNP-like_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21789">
        <property type="entry name" value="TNP-like_RNaseH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21787">
        <property type="entry name" value="TNP-like_RNaseH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposable element P transposase-like RNase H" evidence="1">
        <location>
            <begin position="2"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Transposable element P transposase-like GTP-binding insertion" evidence="2">
        <location>
            <begin position="150"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="Transposable element P transposase-like RNase H C-terminal" evidence="3">
        <location>
            <begin position="351"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0793229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="602" mass="69041" checksum="0DBA6237CDC0CB20" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A7H2</accession>
    <name>A0A5N4A7H2_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phospholipid/glycerol acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_03502</name>
        <name evidence="4" type="ORF">PPYR_12883</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A7H2"/>
    <dbReference type="InParanoid" id="A0A5N4A7H2"/>
    <dbReference type="OrthoDB" id="44277at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07987">
        <property type="entry name" value="LPLAT_MGAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22753:SF14">
        <property type="entry name" value="MONOACYLGLYCEROL_DIACYLGLYCEROL O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22753">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="2">
        <location>
            <begin position="87"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0791702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0793263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="298" mass="34120" checksum="D0C3C77A23C081F3" modified="2020-02-26" version="1">MVIVWMLLLLLAVILLPFMIAVLLYQSALIVTVYVIYCKILRKPYDLLTTTNNVASRAHRYTWYLHGRIWNGYEVQGLENIPDSGPALLIFYHGALPIDIYYLLVTVFFHKDRILHVVADYFLFKVPGLKTLLDCMGVIAGSQETCTKTLKDGNLLAIFPGGVYESQFSHEYNLLWKNRVGFAKVAINAKVPIIPVFTENVREAYRTLRTGRSFFEKIYNATKFPFTPIYGGFPVKLITHIGKPIPYDPELSPEQLKMKVANAIEELIAKHQRTPPSILRAVIDRIPAFRVKHKDHKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A875</accession>
    <name>A0A5N4A875_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_13135</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A875"/>
    <dbReference type="InParanoid" id="A0A5N4A875"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024461719" evidence="2">
        <location>
            <begin position="24"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0793515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="173" mass="18568" checksum="D61869E3F92C4169" modified="2020-02-26" version="1">MKTLLVINFSVLLFFGISPAVHAAENLTDLKPLLDTLVKNLLACTSDVKITNITAIIDKNSKCAATTGETILQEYLSCLLGLLMESLTNLLKNLTGIQKLLFDILKPVLGLVSALLFILGKTLAPVVGAVTNLLTGLLKNEPIKACMQQNTPCDSPLLKLPLIGDLLKSLLKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A8C9</accession>
    <name>A0A5N4A8C9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Sodium-coupled monocarboxylate transporter 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PPYR_13138</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A8C9"/>
    <dbReference type="InParanoid" id="A0A5N4A8C9"/>
    <dbReference type="OrthoDB" id="6132759at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11492">
        <property type="entry name" value="SLC5sbd_NIS-SMVT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051163">
        <property type="entry name" value="Sodium:Solute_Symporter_SSF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00813">
        <property type="entry name" value="sss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985">
        <property type="entry name" value="SODIUM-COUPLED MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985:SF21">
        <property type="entry name" value="SODIUM-DEPENDENT MULTIVITAMIN TRANSPORTER-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="10" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="13"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="265"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="414"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="440"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="505"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAB0793518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="565" mass="62775" checksum="53AFDA86B0906BD0" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A8W0</accession>
    <name>A0A5N4A8W0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PPYR_13386</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A8W0"/>
    <dbReference type="InParanoid" id="A0A5N4A8W0"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000065">
        <property type="entry name" value="B-cell CLL/lymphoma 6, member B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001759">
        <property type="entry name" value="Crooked legs, isoform F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002048">
        <property type="entry name" value="Crooked legs, isoform F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000253">
        <property type="entry name" value="Crooked legs, isoform H"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000508">
        <property type="entry name" value="Myeloid zinc finger 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000358">
        <property type="entry name" value="zinc finger protein 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001498">
        <property type="entry name" value="Zinc finger protein 404"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050636">
        <property type="entry name" value="C2H2-ZF_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47772:SF9">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47772">
        <property type="entry name" value="ZINC FINGER PROTEIN 200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="18"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="415"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="443"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="471"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="499"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="527"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="555"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="583"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="611"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="639"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="667"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="695"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="723"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="751"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="779"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="807"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="835"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="867"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="895"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAB0793766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1057" mass="118573" checksum="2B3B304C3E68143C" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-06-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A915</accession>
    <name>A0A5N4A915_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_13433</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A915"/>
    <dbReference type="InParanoid" id="A0A5N4A915"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.20">
        <property type="entry name" value="Pheromone/general odorant binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006170">
        <property type="entry name" value="PBP/GOBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036728">
        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01395">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024352091" evidence="1">
        <location>
            <begin position="18"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0793813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="145" mass="17152" checksum="583BB20ED50A7243" modified="2020-02-26" version="1">MKVLCFVLLWCVMQVLSRDVPDESLDDYAFECFKELNIDKAKFSSYFDDDMRMRDLDETGIKIMKCGVEKSNFFNQDGNVNKDVMMKSVTKWLKLRLTKGGDKDWEALAEQFWGKCEDRLKGEDKVEVMKNWNHCFTDEVILYNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A941</accession>
    <name>A0A5N4A941_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_13447</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A941"/>
    <dbReference type="FunCoup" id="A0A5N4A941">
        <property type="interactions" value="1371"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A941"/>
    <dbReference type="OrthoDB" id="410701at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000009">
        <property type="entry name" value="Carnitinyl-CoA dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.12.10:FF:000001">
        <property type="entry name" value="Probable enoyl-CoA hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF171">
        <property type="entry name" value="SD19268P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0793827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="294" mass="32109" checksum="CF955444A2177395" modified="2020-02-26" version="1">MRALSFFPKTLNLNIIRRTFATPVQQVQQVQDVDLSHLCEKDTGISVLSLNCIQNRNTITSSLVDNLNRVFDTVGKLDTKVLIIKSNVPKIFCTGADLKERLKMSERDVASFVNYIRSTLHRLHLLPMPVIAALDGSALGGGLEMALACDIRVAASSIKLGLVETRLAIIPGAGGSVRLPRLINPALAKELIYTAKVFDGSEAKAMGVVNHVVEQNDDGNAAYLRSLGIAREILPNGPIALRMAKFAINKGVEVDINTALSFEEAAYSQVIPTRDRIEGLRAFVEKRRPSYTGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A993</accession>
    <name>A0A5N4A993_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">MRH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PPYR_13479</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A993"/>
    <dbReference type="InParanoid" id="A0A5N4A993"/>
    <dbReference type="OrthoDB" id="4504960at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005537">
        <property type="term" value="F:D-mannose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007041">
        <property type="term" value="P:lysosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000479">
        <property type="entry name" value="CIMR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044865">
        <property type="entry name" value="MRH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15071:SF0">
        <property type="entry name" value="MANNOSE 6-PHOSPHATE RECEPTOR-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15071">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE RECEPTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00878">
        <property type="entry name" value="CIMR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01404">
        <property type="entry name" value="CIMR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50911">
        <property type="entry name" value="Mannose 6-phosphate receptor domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51914">
        <property type="entry name" value="MRH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024351804" description="MRH domain-containing protein" evidence="9">
        <location>
            <begin position="21"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1016"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="10">
        <location>
            <begin position="299"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="10">
        <location>
            <begin position="447"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="10">
        <location>
            <begin position="582"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="10">
        <location>
            <begin position="880"/>
            <end position="999"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0793859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1068" mass="120231" checksum="0DAFD2D4F7418FCB" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AAA6</accession>
    <name>A0A5N4AAA6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PPYR_13873</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">1611_PpyrPB1</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0794253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AAA6"/>
    <dbReference type="FunCoup" id="A0A5N4AAA6">
        <property type="interactions" value="66"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AAA6"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11056">
        <property type="entry name" value="CYP6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000042">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050476">
        <property type="entry name" value="Insect_CytP450_Detox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292:SF54">
        <property type="entry name" value="CYP9F3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0492">Microsome</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="472"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAB0794253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="532" mass="61657" checksum="E927551CE3DD7537" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AAK6</accession>
    <name>A0A5N4AAK6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP synthase subunit beta</fullName>
            <ecNumber evidence="11">7.1.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PPYR_11192</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>ATP + H2O + 4 H(+)(in) = ADP + phosphate + 5 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) and CF(0) have multiple subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="11"/>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0794353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AAK6"/>
    <dbReference type="InParanoid" id="A0A5N4AAK6"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042776">
        <property type="term" value="P:proton motive force-driven mitochondrial ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18110">
        <property type="entry name" value="ATP-synt_F1_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18115">
        <property type="entry name" value="ATP-synt_F1_beta_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01133">
        <property type="entry name" value="F1-ATPase_beta_CD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000026">
        <property type="entry name" value="ATP synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01347">
        <property type="entry name" value="ATP_synth_beta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005722">
        <property type="entry name" value="ATP_synth_F1_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050053">
        <property type="entry name" value="ATPase_alpha/beta_chains"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01039">
        <property type="entry name" value="atpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15184">
        <property type="entry name" value="ATP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15184:SF71">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47917">
        <property type="entry name" value="C-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="N-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0139">CF(1)</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="12">
        <location>
            <begin position="141"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAB0794353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="430" mass="46846" checksum="2BC0329E9251E2FC" modified="2020-02-26" version="1">MTQGRVIAIIGAIIDVKFYDHLPPLFNALEVRAGDRKLVLEVAQHLGKTTVRAIAMDGTEGLVRGLPVIDTGFPIRVPVGVETLGRIMNVIGEPIDDRGPINSPTLASIHADCPELLEMNVKQEVLETGIKVIDLLAPYAKGSKIGLFGGAGVGKTVVIMELINNIAKAHGGYSVFAGVGERTREGNDLYHEMIESGVISITDNTSKVSLVYGQMNEPPGARARVALTGLTVAEYFRDQERQDVLLFVDNIYRFSQAGSEVSALLGRMPSAMGYQPTLATDMAALQERITTTTRGSITSVQAVYVPADDLTDAAPATTFSHLDATTVLSQNAQAYKSLQDLIAILGMDELSEQDKLTVQRARRVQRFLSQPFHVAEIFTGHPGKFVPLEETIKGFQDILKGDYDDFPEQAFYMVGSIEEVVEKANKLRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ABJ7</accession>
    <name>A0A5N4ABJ7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidase M13 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PPYR_11544</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0794705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ABJ7"/>
    <dbReference type="InParanoid" id="A0A5N4ABJ7"/>
    <dbReference type="OrthoDB" id="5808441at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF229">
        <property type="entry name" value="NEPRILYSIN-2-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="5">
        <location>
            <begin position="304"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="48"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0794705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="625" mass="69762" checksum="B3765F5377C80442" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AD56</accession>
    <name>A0A5N4AD56_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 17">Vesicle-fusing ATPase</fullName>
            <ecNumber evidence="4 17">3.6.4.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PPYR_12102</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">1611_PpyrPB1</strain>
            <tissue evidence="20">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16 17">Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 17">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="17">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 17">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.6" evidence="4 17"/>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0795263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AD56"/>
    <dbReference type="FunCoup" id="A0A5N4AD56">
        <property type="interactions" value="2055"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AD56"/>
    <dbReference type="OrthoDB" id="9982946at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035494">
        <property type="term" value="P:SNARE complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19504">
        <property type="entry name" value="RecA-like_NSF-SEC18_r1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000026">
        <property type="entry name" value="vesicle-fusing ATPase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000031">
        <property type="entry name" value="vesicle-fusing ATPase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000166">
        <property type="entry name" value="vesicle-fusing ATPase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000012">
        <property type="entry name" value="Vesicle-fusing ATPase protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000187">
        <property type="entry name" value="Vesicular-fusion ATPase SEC18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029067">
        <property type="entry name" value="CDC48_domain_2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003338">
        <property type="entry name" value="CDC4_N-term_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054419">
        <property type="entry name" value="NSF_ATPase_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039812">
        <property type="entry name" value="Vesicle-fus_ATPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23078:SF3">
        <property type="entry name" value="VESICLE-FUSING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23078">
        <property type="entry name" value="VESICULAR-FUSION PROTEIN NSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02359">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21964">
        <property type="entry name" value="NSF_ATPase_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01073">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="ADC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54585">
        <property type="entry name" value="Cdc48 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 17" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13 17" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="10 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14 17" id="KW-0653">Protein transport</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 17" id="KW-0813">Transport</keyword>
    <feature type="domain" description="CDC48 N-terminal subdomain" evidence="19">
        <location>
            <begin position="2"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="18">
        <location>
            <begin position="252"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="18">
        <location>
            <begin position="535"/>
            <end position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00056429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU367045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAB0795263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="745" mass="82781" checksum="101E406A83815DE7" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ADC7</accession>
    <name>A0A5N4ADC7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MADF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_12165</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0795326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ADC7"/>
    <dbReference type="InParanoid" id="A0A5N4ADC7"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21505">
        <property type="entry name" value="MADF DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21505:SF12">
        <property type="entry name" value="MADF DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00595">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51029">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MADF" evidence="2">
        <location>
            <begin position="10"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0795326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="195" mass="22820" checksum="0861D315CBF65BB2" modified="2020-02-26" version="1">MSWSREQCEILIQEYQKHPCLYATKSVLYKNRHARQHALEKIEAVLKEVRPSVTINEIKTKFGGLKTNFLNEYKKWNVSRRSGAGDNDDDDSLYKPTIWYFKVMFFLLEHCKVRLAVDSLTEDVETEQEDTERDSQSSEVQEYVVGEDGVLHDAGDENVQSPDIQNQRRGNCGKSQWKKISYGKRQIHLHLLIRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AE44</accession>
    <name>A0A5N4AE44_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Sedoheptulokinase</fullName>
            <ecNumber evidence="10">2.7.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Carbohydrate kinase-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PPYR_12408</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">1611_PpyrPB1</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Acts as a modulator of macrophage activation through control of glucose metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>sedoheptulose + ATP = D-sedoheptulose 7-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23844"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16802"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FGGY kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.14" evidence="10"/>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0795569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AE44"/>
    <dbReference type="InParanoid" id="A0A5N4AE44"/>
    <dbReference type="OrthoDB" id="10264182at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050277">
        <property type="term" value="F:sedoheptulokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071396">
        <property type="term" value="P:cellular response to lipid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901701">
        <property type="term" value="P:cellular response to oxygen-containing compound"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006091">
        <property type="term" value="P:generation of precursor metabolites and energy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046496">
        <property type="term" value="P:nicotinamide nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006163">
        <property type="term" value="P:purine nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009617">
        <property type="term" value="P:response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07777">
        <property type="entry name" value="ASKHA_NBD_FGGY_SHK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000111">
        <property type="entry name" value="Sedoheptulokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000132">
        <property type="entry name" value="Sedoheptulokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="FGGY_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196:SF67">
        <property type="entry name" value="SEDOHEPTULOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase FGGY N-terminal" evidence="14">
        <location>
            <begin position="29"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate kinase FGGY N-terminal" evidence="14">
        <location>
            <begin position="132"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00052736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00057196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00066341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00069425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00076706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAB0795569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="491" mass="54068" checksum="7B5CC233B5A35199" modified="2020-02-26" version="1">MENIIKLTLNNISSNDFRGKARRKMAGGLILGIDLGTTSVKVCVVNVTSREVIAKQSKDTQSHTPSDQGTGGSKQDVHKIIYALNTCVAKLPKDLLRKITRIGICGQMHGVVFWNSGKVKAWERIERNGTLVRYDVVQEELTALYTWQDSRCDSAFIESLPMPQSHLPTYSGYGVSTMFWMAKHRPEKMSRYNCAGTIQDFTVAMLCDLEKPVMSVQNAASWGYFDCKNNCWNFTLLKRADFPVHFLPEVVNSGKFVGTLADDWHSIPKGTPIGAGLGDLQCSVLATIESVHDAVLNISTSAQLAFVVENYEPTNGPPEVSPIEYFPYFHGKFLAVAASLNGGNALAMFVKMLQQWTMELGFSIPQSQIWERVLALGLDDNTRSDLQVQPTLLCERHQPDVHASVTNINIGNLGLGQAFRALCHGLLQNLHNMMPRDILSKAHITRIVGNGSGLSRNKVLQKEVQQLYQLPLVFTTGGDAAKGAALAVSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AET7</accession>
    <name>A0A5N4AET7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PiggyBac transposable element-derived protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_09809</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0795748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AET7"/>
    <dbReference type="InParanoid" id="A0A5N4AET7"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052638">
        <property type="entry name" value="PiggyBac_TE-derived"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47055">
        <property type="entry name" value="DDE_TNP_1_7 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47055:SF3">
        <property type="entry name" value="PHORBOL-ESTER_DAG-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="1">
        <location>
            <begin position="2"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0795748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="281" mass="32193" checksum="C9CA09881B943B6D" modified="2020-02-26" version="1">MLNKKYQQWGIIHEKLSVDEAMTRYYGHHSSLVRGKPVRFGFKNWSLCSSNGYCYSVDTYCGKTKGNPGDIQQPLGSRVVLSLLKCVCVYPVIIFLSLLSDLKRLGFRATGTLRQNRTEKSPLIPVKEMEKKKRGSYDSAFDSKNELLLIRWNDNSVCTIATNYDFLEPLQNDDVKQPNVFKAYNNGMGGVDSNDQVVNNYRISVRGKKWYWPLITSMFNVAMVNAWKLHQLVSEDKMDLLLFVRNVTRYYLRFSTKEHGKSRNSASVPKSIVEDDIGSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AEX4</accession>
    <name>A0A5N4AEX4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Dynein light chain Tctex-type 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PPYR_09948</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein light chain Tctex-type family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0795887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AEX4"/>
    <dbReference type="InParanoid" id="A0A5N4AEX4"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1140.40:FF:000001">
        <property type="entry name" value="Dynein light chain Tctex-type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.40">
        <property type="entry name" value="Tctex-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005334">
        <property type="entry name" value="Tctex-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038586">
        <property type="entry name" value="Tctex-1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21255:SF19">
        <property type="entry name" value="DYNEIN LIGHT CHAIN TCTEX-TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21255">
        <property type="entry name" value="T-COMPLEX-ASSOCIATED-TESTIS-EXPRESSED 1/ DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03645">
        <property type="entry name" value="Tctex-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0243">Dynein</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0795887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="109" mass="12122" checksum="C6A7BE37CC61F4C7" modified="2020-02-26" version="1">MEEEDNQFVVDDVSKIIKETIESTISGNVYQQDKVNQWSAAVSEQCLSALSKLKKSFKYVVTCSIMQKTGAGLHTASSCYWDSSTDGTCTVRWENKSMYCIVSVFGLAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AEZ2</accession>
    <name>A0A5N4AEZ2_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4806 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_09961</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0795900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AEZ2"/>
    <dbReference type="InParanoid" id="A0A5N4AEZ2"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032071">
        <property type="entry name" value="DUF4806"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33053">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33053:SF24">
        <property type="entry name" value="TRANSPOSASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16064">
        <property type="entry name" value="DUF4806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4806" evidence="2">
        <location>
            <begin position="546"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="418"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0795900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="666" mass="75315" checksum="CE4385066EDD316F" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AGQ3</accession>
    <name>A0A5N4AGQ3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">O-acyltransferase WSD1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_10530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AGQ3"/>
    <dbReference type="InParanoid" id="A0A5N4AGQ3"/>
    <dbReference type="OrthoDB" id="619536at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045034">
        <property type="entry name" value="O-acyltransferase_WSD1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009721">
        <property type="entry name" value="O-acyltransferase_WSD1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31650">
        <property type="entry name" value="O-ACYLTRANSFERASE (WSD1-LIKE) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31650:SF1">
        <property type="entry name" value="WAX ESTER SYNTHASE_DIACYLGLYCEROL ACYLTRANSFERASE 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06974">
        <property type="entry name" value="WS_DGAT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="271"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="O-acyltransferase WSD1 C-terminal" evidence="2">
        <location>
            <begin position="394"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0796469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="551" mass="61637" checksum="2A79CAF558C67335" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AH92</accession>
    <name>A0A5N4AH92_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Dynein light chain Tctex-type 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PPYR_10791</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein light chain Tctex-type family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AH92"/>
    <dbReference type="InParanoid" id="A0A5N4AH92"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1140.40:FF:000001">
        <property type="entry name" value="Dynein light chain Tctex-type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.40">
        <property type="entry name" value="Tctex-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005334">
        <property type="entry name" value="Tctex-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038586">
        <property type="entry name" value="Tctex-1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21255:SF19">
        <property type="entry name" value="DYNEIN LIGHT CHAIN TCTEX-TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21255">
        <property type="entry name" value="T-COMPLEX-ASSOCIATED-TESTIS-EXPRESSED 1/ DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03645">
        <property type="entry name" value="Tctex-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0243">Dynein</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0796730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="130" mass="14544" checksum="C5BD405619409A44" modified="2020-02-26" version="1">MFGKQNIVSKNILDVCQNLFKMEEEDNQFVVDDVSKIIKETIESTISGNVYQQDKVNQWSAAVSEQCLSALSKLKKSFKYVVTCSIMQKTGAGLHTASSCYWDSSTDGTCTVRWENKSMYCIVSVFGLAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-06-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AHA3</accession>
    <name>A0A5N4AHA3_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_10752</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AHA3"/>
    <dbReference type="InParanoid" id="A0A5N4AHA3"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0796691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="160" mass="17551" checksum="04F739DE49D5DA6D" modified="2020-02-26" version="1" fragment="single">TLTVDLVSAEVVAYVVVDSMQQVPVIVGQTFLNRTGVTLLLRDHQIRLFENHLAALPEVASLPPRKLPLWSKNAAVIPPNTIGFIEIANQEHHEGEVYVKATTRQKPGGEYNIPGCVTTIGGVIAIQNISTNHLTFRQHQLIARGTPCENEISQNEVSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AHL4</accession>
    <name>A0A5N4AHL4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Neurotransmitter-gated ion-channel ligand-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PPYR_10840</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">1611_PpyrPB1</strain>
            <tissue evidence="20">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Postsynaptic cell membrane</location>
            <topology evidence="16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AHL4"/>
    <dbReference type="InParanoid" id="A0A5N4AHL4"/>
    <dbReference type="OrthoDB" id="5975154at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022848">
        <property type="term" value="F:acetylcholine-gated monoatomic cation-selective channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18997">
        <property type="entry name" value="LGIC_ECD_nAChR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19051">
        <property type="entry name" value="LGIC_TM_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000073">
        <property type="entry name" value="Neuronal acetylcholine receptor subunit alpha-9-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000016">
        <property type="entry name" value="Nicotinic acetylcholine receptor subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002394">
        <property type="entry name" value="Nicotinic_acetylcholine_rcpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00860">
        <property type="entry name" value="LIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00254">
        <property type="entry name" value="NICOTINICR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15 17" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 17" id="KW-0406">Ion transport</keyword>
    <keyword evidence="14" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="9 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="17" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0770">Synapse</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 17" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024447886" description="Neurotransmitter-gated ion-channel ligand-binding domain-containing protein" evidence="17">
        <location>
            <begin position="28"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="239"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="270"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="302"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="459"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="18">
        <location>
            <begin position="32"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="19">
        <location>
            <begin position="245"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAB0796779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="22">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="487" mass="56300" checksum="3B6C81563DB79391" modified="2020-02-26" version="1">MALVIEMKTFLFVCFALKILLQDKCFGDEHEARLMRQLMSNYDPAVRPVKNSSLPLSVIFGISLHHIIDVDEKNQILTTNCWITQIWIDHHLKWNASDFSGIKVIRIPYNRVWRPDLILYNNADPQFQASVINTNVIVSNSGEVVWLSHGIYRSSCDINVEYFPFDLQNCHMKWASWTYDGYQIELMKQSEEGDVSNYQANGEFDLLSFSAIKHVEYYSCCPEPYPDITYTIKLKRRPLFYVFNLILPCILINGIALLVFYVPSESGEKVTLGISALLSMTVFLMTIRETLPPTEKTPLISLYYGVSICLVSFASGLSVVTLNIYHRGVRGAAVPKIIRKVVLERLSHIVFMRLETNNARHRNSQMQEVNPQTGNRLDCQWSWTDKGSQKDDCCFQQRSPRFLTRDRVDHIDYFENQIIRILHKVHASIDRNEQRLAEQDRRELTEMEWKQASLVLDRLLLAVFFLITIITTTTILCGGPPRDDLTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2024-05-29" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AIY9</accession>
    <name>A0A5N4AIY9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_08314</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AIY9"/>
    <dbReference type="InParanoid" id="A0A5N4AIY9"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20905:SF32">
        <property type="entry name" value="ARYLALKYLAMINE N-ACETYLTRANSFERASE-LIKE 7, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20905">
        <property type="entry name" value="N-ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0797320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="248" mass="28515" checksum="2BCB6DDA093C28A1" modified="2020-02-26" version="1">MPAESARWPRPETIPYPNVWKRFKGRKEINGVIPSFWIQDVPEDEFQNVVNCMVERFCTEEPLTKYSGMLKDPKSVEDMRNLWIYMLHNRVGLACYKENSDPRGKPIFAGVNCMHIKKKHEPEYKFSGTTVLQIFGTLVAAANKTDLYEFFGTDAFLSSLGLYVLPEFRGQGIGLEMLLARQEMCKALKVKAAITLFTSTVSQVLAEKAGYNVLNEISYADLRDVYKFDYPGAEEKHKSVKYMYVLYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AJ72</accession>
    <name>A0A5N4AJ72_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP-binding cassette sub-family F member 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PPYR_08337</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AJ72"/>
    <dbReference type="FunCoup" id="A0A5N4AJ72">
        <property type="interactions" value="1662"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AJ72"/>
    <dbReference type="OrthoDB" id="2110130at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000467">
        <property type="entry name" value="ATP-binding cassette sub-family F member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000104">
        <property type="entry name" value="ATP-binding cassette sub-family F member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF15">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="97"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="409"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="176"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00073918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0797343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="632" mass="71680" checksum="A8474CC642F65E24" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AJ76</accession>
    <name>A0A5N4AJ76_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Calponin-homology (CH) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_08365</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AJ76"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056343">
        <property type="entry name" value="CFAP47_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053879">
        <property type="entry name" value="HYDIN_VesB_CFA65-like_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45912">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45912:SF3">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24529">
        <property type="entry name" value="CFAP47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22544">
        <property type="entry name" value="HYDIN_VesB_CFA65-like_Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="1670"/>
            <end position="1793"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0797371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="2187" mass="247383" checksum="68E23000422EDDCF" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AJL7</accession>
    <name>A0A5N4AJL7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Lipid-binding serum glycoprotein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_08510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AJL7"/>
    <dbReference type="InParanoid" id="A0A5N4AJL7"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.30">
        <property type="entry name" value="Haemolymph juvenile hormone binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010562">
        <property type="entry name" value="Haemolymph_juvenile_hormone-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038606">
        <property type="entry name" value="To_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008:SF32">
        <property type="entry name" value="CIRCADIAN CLOCK-CONTROLLED PROTEIN DAYWAKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008">
        <property type="entry name" value="PROTEIN TAKEOUT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06585">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00700">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0797517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="253" mass="28664" checksum="36FF4CCAC0A0C9CB" modified="2020-02-26" version="1">MLVMYERYPIMVQQVLTVLTFTLFFCTGNSQLPSDVQKCSITDDDCLKTTIQTVLRHLQNDPSVFHVASVQPMRLSQGVVPAGQVWTFDQYYHDVEMYNHAMSTVTHVESSITNNTLTFAINISNPDVVFKTDYEYKNAFFDGFNVTSKGKVIHHHEGYVGVVQITGDIEGEGDTKHVTITDVAVSFVTSKLTFDYNTADPQFDAWLGKLFADNMESIFNDMKGAYGDFYAYAYNTIIITPIFTTFSYNDLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AKG2</accession>
    <name>A0A5N4AKG2_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxylesterase type B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_08792</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AKG2"/>
    <dbReference type="InParanoid" id="A0A5N4AKG2"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142:SF1">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024284162" description="Carboxylesterase type B domain-containing protein" evidence="5">
        <location>
            <begin position="20"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="6">
        <location>
            <begin position="22"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0797799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="564" mass="63456" checksum="8050F4286CE1D7AA" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AKQ1</accession>
    <name>A0A5N4AKQ1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Symplekin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_08869</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AKQ1"/>
    <dbReference type="FunCoup" id="A0A5N4AKQ1">
        <property type="interactions" value="2129"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AKQ1"/>
    <dbReference type="OrthoDB" id="331600at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021850">
        <property type="entry name" value="Symplekin/Pta1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032460">
        <property type="entry name" value="Symplekin/Pta1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022075">
        <property type="entry name" value="Symplekin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15245:SF20">
        <property type="entry name" value="SYMPLEKIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15245">
        <property type="entry name" value="SYMPLEKIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11935">
        <property type="entry name" value="SYMPK_PTA1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12295">
        <property type="entry name" value="Symplekin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Symplekin/Pta1 N-terminal" evidence="5">
        <location>
            <begin position="103"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="Symplekin C-terminal" evidence="6">
        <location>
            <begin position="813"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="326"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF11935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0797876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1059" mass="119710" checksum="73D01706F7D34CC8" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AL15</accession>
    <name>A0A5N4AL15_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific protein-tyrosine kinase</fullName>
            <ecNumber evidence="1">2.7.10.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PPYR_08989</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.2" evidence="1"/>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AL15"/>
    <dbReference type="FunCoup" id="A0A5N4AL15">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AL15"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030838">
        <property type="term" value="P:positive regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031274">
        <property type="term" value="P:positive regulation of pseudopodium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007266">
        <property type="term" value="P:Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055175">
        <property type="entry name" value="ACK/TNK-like_SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051296">
        <property type="entry name" value="Cdc42_Effector_BORG/CEP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15344">
        <property type="entry name" value="CDC42 EFFECTOR PROTEIN BORG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15344:SF12">
        <property type="entry name" value="CRIB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00786">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22931">
        <property type="entry name" value="SAM_TNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00285">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="CRIB" evidence="9">
        <location>
            <begin position="107"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="211"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="218"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0797996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="643" mass="70999" checksum="066C6E0BD5B5A620" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AN47</accession>
    <name>A0A5N4AN47_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Putative nuclease HARBI1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Harbinger transposase-derived nuclease</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PPYR_06655</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Transposase-derived protein that may have nuclease activity. Does not have transposase activity.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HARBI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0798775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AN47"/>
    <dbReference type="InParanoid" id="A0A5N4AN47"/>
    <dbReference type="OrthoDB" id="6740069at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026103">
        <property type="entry name" value="HARBI1_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF289">
        <property type="entry name" value="DDE TNP4 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02086">
        <property type="entry name" value="PUTNUCHARBI1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="13">
        <location>
            <begin position="154"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAB0798775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="350" mass="40191" checksum="53FB3E2F42B2CBD4" modified="2020-02-26" version="1">MLDISLSSFSSSSDEEEAPARRIRFIRDRNNPFQIYDDIDFKMRYRFSKPIVQNLLHMFGHLIEPKTKRNKSIDGLTQLLITLRFYATGTYQRVIGDHINVNQSTACRVINRVTRHLARQRPNFINMPKNQDDILQVCRGFYRIRGFPKVIGAIDCTHIKIQSPGGNNAELYRNRKGFFSINVQAICDATLKIRHIISRWPGSVHDSTIFNDSPLIPEFEADQYGAGTYLLGDSGYACKKYLLTPFLNPRTPAEERYNRSHVATRNTIERTFGVLKRRFPCLFLGLRNTVHVCLMIIVACAVLHNIAIDSNDHLNEFFENQGRAEDIPIAEGYRNENTSIRTALVNTTFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-06-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AN67</accession>
    <name>A0A5N4AN67_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_06672</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0798792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AN67"/>
    <dbReference type="InParanoid" id="A0A5N4AN67"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0798792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="111" mass="12250" checksum="F8867CCCB669745A" modified="2020-02-26" version="1">MRGSDRTTRYRKWKPSYFPCNNSIGQSAPTSCDLAIAVMKPAGGSSPWSANLQFIEREPLKKCGPITLQRSPSTSTINIQSPQASEIATKISRNYKEQQRLGESDVSVPFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4APH4</accession>
    <name>A0A5N4APH4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CHK kinase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_07094</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4APH4"/>
    <dbReference type="InParanoid" id="A0A5N4APH4"/>
    <dbReference type="OrthoDB" id="190089at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015897">
        <property type="entry name" value="CHK_kinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004119">
        <property type="entry name" value="EcKL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012">
        <property type="entry name" value="PROTEIN KINASE-LIKE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012:SF30">
        <property type="entry name" value="PROTEIN KINASE-LIKE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02958">
        <property type="entry name" value="EcKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00587">
        <property type="entry name" value="CHK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHK kinase-like" evidence="1">
        <location>
            <begin position="127"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0799214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="412" mass="48043" checksum="8E84306C8D625903" modified="2020-02-26" version="1">MDDCDKVVLNSKAQSLLNSLITNLGIENYTLNITRGNAKGDNYLGVIGKIHVKTEGATWNWIIKCAPEASQFRTTVPVAKVYQREVYVYEKILAEYQKFQEEKGVTTPFRSYAKYYTSLLEEPFETIILEDMKAVGYKLYNRQEPLDYHHALLAIREYGRFHAFSFAIRDQKPDLFHEFQQNVPEVFYDLLVNSESSRQLIQYQCNQIRDSISQIDSKRAYDNFSKFQDHMLELVKKLVTVEAAGPYAVISHGDCWINNFLFKYSKLQKSPTDMCLIDWQMARVGSPVLDLSCFLFTSTDKQLRDQHYDSLIKEYYDSLSSFLIELGSDPEVLFPFNILQEHLKIFSVYGLFMAIQSLYFMVSGEDEIPDVHNFTSEEEGMVQMKYVPKNIDRYTSRIRDVVVDFEKFGYNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AQA2</accession>
    <name>A0A5N4AQA2_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Alpha-L-iduronidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_07323</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 39 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AQA2"/>
    <dbReference type="FunCoup" id="A0A5N4AQA2">
        <property type="interactions" value="102"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AQA2"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003940">
        <property type="term" value="F:L-iduronidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1500">
        <property type="entry name" value="Glycosyl hydrolase domain, family 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049165">
        <property type="entry name" value="GH39_as"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049167">
        <property type="entry name" value="GH39_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049166">
        <property type="entry name" value="GH39_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000514">
        <property type="entry name" value="Glyco_hydro_39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051923">
        <property type="entry name" value="Glycosyl_Hydrolase_39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12631">
        <property type="entry name" value="ALPHA-L-IDURONIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12631:SF8">
        <property type="entry name" value="ALPHA-L-IDURONIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01229">
        <property type="entry name" value="Glyco_hydro_39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21200">
        <property type="entry name" value="Glyco_hydro_39_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00745">
        <property type="entry name" value="GLHYDRLASE39"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01027">
        <property type="entry name" value="GLYCOSYL_HYDROL_F39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolases family 39 N-terminal catalytic" evidence="5">
        <location>
            <begin position="13"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-iduronidase C-terminal" evidence="6">
        <location>
            <begin position="408"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600514-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF21200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0799443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="507" mass="59147" checksum="7F975CE810D67F0A" modified="2020-02-26" version="1">MGLPQTDDENSYYDPYTYDFWYNITFAIANRYIDRYGARYVKKWRFESWNEPDLRNYNILNFTLSQYLSYIEACEVALRAAFRAGGAQGKLKFGGPAGLFKSIGKHPLCWGSLEMCNLKGRSCPFQYISFHKKGNGSANAVSHDSIQLLNILYSKFPNLKGIPVSNDEADVLSNWSRSLDWRGDVRYAAMIAKIVIDFYKELVVKMEIPVQLLSFDNGFLNYNPYFFTQRTLLARFQMNNTNPTHIQFIRKPAYSVMGLLSLLGDEYLKENVTPPDPFVQFLATRSIRNKNESHLISLLITYVNDEREDKNVKEIRVNFNNLPNNECKYVIYVLDNKITNPFLSWRKHGSPVFPAMKLRNLMRHCEEPYRLEGPRSILNLTLQMNLALPSVALINICSRTSQPLGRVTRLVAHNITRNEVLLVWKDSKIRSKCILTYEVEFRPQVESCNRTKFRRINHRDTIFLSYHHAVEGNNSVEEWTQGWYRVRAVDYWNVPGRYSKVIRYSVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AQJ3</accession>
    <name>A0A5N4AQJ3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_07413</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AQJ3"/>
    <dbReference type="InParanoid" id="A0A5N4AQJ3"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009755">
        <property type="term" value="P:hormone-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24372">
        <property type="entry name" value="GLYCOPROTEIN HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24372:SF82">
        <property type="entry name" value="RICKETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="436"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0799533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="499" mass="55978" checksum="B7592D7FEE6E99A6" modified="2020-02-26" version="1" fragment="single">VLQSCGLKDIPTEALHPLTKLGTLLLKRNQIKEIAPEAFVNLTSLRVLELDDNALMEIPSALTKLPSLQELSISGNRIKFIPGGLLQKSPGLAVLELKGNPLVQVDSNAFSYLPRLRNLILSEARGLSTFPVLNGTTSLEVLRLDRAGISSVPSSLCYTCPRLRSLDLKSNKLTSIPDLNNCKEIRVLDLASNRIKSVEERPFHGMTKMHDLLLAHNEIEYVPNDAFFGLSRLQFLDMESNHVSYIHPDAFLAISHIEDLNLGNNIFPHLPTAGLERLRHLKTFNNPHLRDFPSPENFPRIQSLVLSYAYHCCAFIPLIPSNPPPPAKVKDIVLFPGDDEDIDLTFWNSSGTDLWPQNQNISHKLGKTFREFWDHIGGSDFTYPGNFPSYMEEYSEEDVLKVPNSDIPPGKIQCLPLPGPFLPCQDLFDWWTLRCGVWLVFLCAMLGNGTVVFVLVFSRSKMDVPRFLVCNLAAADFFMGIYLGRSPSHGPCENLQYLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AQT6</accession>
    <name>A0A5N4AQT6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_07561</name>
        <name evidence="3" type="ORF">PPYR_07562</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AQT6"/>
    <dbReference type="InParanoid" id="A0A5N4AQT6"/>
    <dbReference type="OrthoDB" id="1434354at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902936">
        <property type="term" value="F:phosphatidylinositol bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174">
        <property type="entry name" value="ALPHA-TOCOPHEROL TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174:SF213">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="142"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0799681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0799682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="277" mass="31577" checksum="9CFC6356E319D36D" modified="2020-02-26" version="1">MATQFGFSVRELFKLNRVSEEGIDAIKTWQSGTKDPKLSDQQIALFLIACNGNHEFAMKTIQAYIKVKTGTPKLFKGWNISNENLQKILSVVNMAVLPKRYSNSAIITTHFKDTDPMNFDFNSFCQLCCMTVEGILIDDHPPDDVILIIDLKGVTAIHLMGIEMKLLGAFLEYGQDCMPLRIQTIHVLNANYLTYAGYKMFQLFATSDEPSKVQFYQDGESLDKFHEAHVPKKYLPRDYGGDLESSGEYHEQNVQKLSRMQYHLDALDQQFFPSGTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AQW9</accession>
    <name>A0A5N4AQW9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Medium-chain acyl-CoA ligase ACSF2, mitochondrial</fullName>
            <ecNumber evidence="4">6.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PPYR_07488</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Acyl-CoA synthases catalyze the initial reaction in fatty acid metabolism, by forming a thioester with CoA. Has some preference toward medium-chain substrates. Plays a role in adipocyte differentiation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a medium-chain fatty acid + ATP + CoA = a medium-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:48340"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:59558"/>
            <dbReference type="ChEBI" id="CHEBI:90546"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>octanoate + ATP + CoA = octanoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:33631"/>
            <dbReference type="ChEBI" id="CHEBI:25646"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57386"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.2" evidence="4"/>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AQW9"/>
    <dbReference type="InParanoid" id="A0A5N4AQW9"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000008">
        <property type="entry name" value="2,3-dihydroxybenzoate-AMP ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF5">
        <property type="entry name" value="MEDIUM-CHAIN ACYL-COA LIGASE ACSF2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="8">
        <location>
            <begin position="8"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="9">
        <location>
            <begin position="371"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0799608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="460" mass="51211" checksum="785787D60A83A8FE" modified="2020-02-26" version="1">MLTVIFKVTINPKYQAAELQHALKLCDVKALVCSEKCKTLDFYGILLSLIPDLKTSEPGNVSCTSIPTLKNIITITTSKLKGTYSYYDVMNFGTGEIGDECEVAAEDIANLQFSSGTTGRPKVVCLTHFQMVNNAYHMGKRLGIDDDQHVYCLQPPLFHVFGICVCLLSAYHNGTTLVLPSPLYSPSANIKAMAEERCTVVCGTPTMYIDLVSLQSKLNLKLYARRALIGASPWPSKLVDDIKDILKIKDIKCLYGATELTSAAFHSLKEVNKHNDVAENIAYIGEYVEAKVVDRNQNVVPFGTPGELCIRGYLTMTGYWKEPELTAKVLNKDRWFRTGDQFVLYEDGRGKVVGRLKDMIIRGGENISPSEVEEFLHTHPDIVEASVIGIADERLGEDVGACIRLREGANLSLENLREFCKGKIATYKIPAQIKIMETFPKTLSGKVQKFVLRQEFSRTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AS25</accession>
    <name>A0A5N4AS25_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4806 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_07986</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0800106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AS25"/>
    <dbReference type="InParanoid" id="A0A5N4AS25"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032071">
        <property type="entry name" value="DUF4806"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34153:SF2">
        <property type="entry name" value="SI:CH211-262H13.3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34153">
        <property type="entry name" value="SI:CH211-262H13.3-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16064">
        <property type="entry name" value="DUF4806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4806" evidence="1">
        <location>
            <begin position="232"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0800106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="351" mass="40311" checksum="9978300B7CBD12C5" modified="2020-02-26" version="1">MYVGVEFSDAGEGIAVICNTWLTPLKQQCWWPPHKKLERYNKALKHVEQPSDDWELYNIKKRLFETDDLQKASIKLKKAETTSDVQSEQEATNPKPIKRIRTLPSRYQNYESSDEEQIPSKFPRPAAIKKLIGNQTVGSEVHVVQSPPFTPNSPSMQVDTDNLDLEISTPTTSSRPTILSSSYNNEEEKRFRSKLFTMLHLIKEQNNKIIDWIENQNPSHSTTVEEITTKFPVNFPLADVDSVSILDEYLKNEKHFTNLVTYLSSFGGKGITQKTNLILKRCISNPLATEYNFCGKRAGKHPFFELNLKNAIVATVRRSTDCTEREIEDIIKCWLKHAPQRQKLQNLKNNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AS32</accession>
    <name>A0A5N4AS32_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cation/H+ exchanger transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PPYR_07898</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0800018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AS32"/>
    <dbReference type="InParanoid" id="A0A5N4AS32"/>
    <dbReference type="OrthoDB" id="423807at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051843">
        <property type="entry name" value="CPA1_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31102">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31102:SF1">
        <property type="entry name" value="CATION_H+ EXCHANGER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="320"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="343"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="376"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="411"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="7">
        <location>
            <begin position="51"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0800018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="467" mass="50563" checksum="22F5945CE37AD829" modified="2020-02-26" version="1">MTVKLPRWANNSDKFSLFLLLFLVWAIAYSIFGDEHVGVNSVIFRLAVLFIVAKLAGCLLGLIRIPPMIGMLLIGVLMRNVGFIEIVGDYAKFTSVLRQLALVNILLPAGLGLDANALRQMGGMIANLAVVPVAIEVVGITILAHLTLDFPWLWGSLLGLLLAAVSPAVIIPCLFELQDLGYGVDKGIHTLVIAASTLNDILCIAIFGVMLGIIFSTQSLLMQIFYGPIIFAMGFAFGAALGFVCQHVPHKDETYVTTLRTLLLGLGCVLAALGSNAIGYMGAGPLGCMVAAFVASFIWKKQGWSSNNPVKANFVLLWKFFEPISFALIGVEVNFSILETNTVTWGLLVLCVPLLLRILTSFATTQCSNLNVKEKIFVALSWIPKATVQATLGPTALVLARNLNDPVLEGYANSVVIIAVISIIITSPIGAILIMQLGPKLLKRTKTVHYRNFGFWLRMTVHPQLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ASS3</accession>
    <name>A0A5N4ASS3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Gamma-butyrobetaine dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PPYR_06106</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amine and polyamine biosynthesis; carnitine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the gamma-BBH/TMLD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000004">
        <property type="protein sequence ID" value="KAB0800366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ASS3"/>
    <dbReference type="FunCoup" id="A0A5N4ASS3">
        <property type="interactions" value="145"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4ASS3"/>
    <dbReference type="OrthoDB" id="406634at2759"/>
    <dbReference type="UniPathway" id="UPA00118"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045329">
        <property type="term" value="P:carnitine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00250">
        <property type="entry name" value="CAS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2020.30:FF:000002">
        <property type="entry name" value="Putative gamma-butyrobetaine dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000001">
        <property type="entry name" value="Trimethyllysine dioxygenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2020.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050411">
        <property type="entry name" value="AlphaKG_dependent_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010376">
        <property type="entry name" value="GBBH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038492">
        <property type="entry name" value="GBBH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696:SF33">
        <property type="entry name" value="GAMMA-BUTYROBETAINE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696">
        <property type="entry name" value="GAMMA-BUTYROBETAINE HYDROXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06155">
        <property type="entry name" value="GBBH-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0124">Carnitine biosynthesis</keyword>
    <keyword evidence="7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma-butyrobetaine hydroxylase-like N-terminal" evidence="11">
        <location>
            <begin position="39"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="TauD/TfdA-like" evidence="10">
        <location>
            <begin position="140"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF06155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAB0800366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="402" mass="47159" checksum="31397F3094E944B8" modified="2020-02-26" version="1">MYPRQQAVTRLKQLTQLIRNYSSARLCENKENLILDIQKQQEVFPLVWLRDNCKCTSCFHEHSTSRIIKWINFDTSPKVSTIEITNDNNLVLQWHDKHISKFSIDWLKERSFREDSQQKYLQENYRPARIPWSQETFDAARKVYEYEDIMKNDHALYNWLVDFARYGMVFTRNAPNDNHAAAKVANRIAFIRKTHYVEEFEVRHTPGTSNVAYLSGSLQLHTDLPYYEYVPGAIILHCLVQTDGEGGDSLLSDGLYHAEKLRQENKEAFDLLSSVEVNWLDIGSEHGDKYHTIFRCPVIRLDLQGNIDKIHYSVPQRDSHFTVDVKHVKPWYEALKLFVNSITHGTSKLKLQPGELLAVDNVRLLHGRTSYQDSDKTERYLKGVYIDWDELFSKMRVLKSQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ATF3</accession>
    <name>A0A5N4ATF3_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_06394</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000004">
        <property type="protein sequence ID" value="KAB0800655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ATF3"/>
    <dbReference type="FunCoup" id="A0A5N4ATF3">
        <property type="interactions" value="13"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4ATF3"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23992">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.20">
        <property type="entry name" value="Pheromone/general odorant binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006170">
        <property type="entry name" value="PBP/GOBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036728">
        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01395">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00708">
        <property type="entry name" value="PhBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024408672" evidence="1">
        <location>
            <begin position="19"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0800655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="133" mass="14928" checksum="554C95158BA4A625" modified="2020-02-26" version="1">MWNTIALSILLLSSTVFSGKVPSDISEDWTKSVNKVKMECLEQGNTTVEAVDAMLATWDIPESLNCFMTCVFEKNGFVDKDGNFTEVLLQHKGVTQENLRKCENAVEAYNKESCNRVYYFCTCMISSVSISNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AU54</accession>
    <name>A0A5N4AU54_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PPYR_05259</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the DExH box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="VVIM01000003">
        <property type="protein sequence ID" value="KAB0800905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AU54"/>
    <dbReference type="OrthoDB" id="6103986at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17917">
        <property type="entry name" value="DEXHc_RHA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21134">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000526">
        <property type="entry name" value="DExH-box ATP-dependent RNA helicase DExH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000002">
        <property type="entry name" value="Putative ATP-dependent RNA helicase DHX36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.590.10">
        <property type="entry name" value="ph1033 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="entry name" value="R3H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007275">
        <property type="entry name" value="YTH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF213">
        <property type="entry name" value="3'-5' RNA HELICASE YTHDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01424">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04146">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50882">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="R3H" evidence="10">
        <location>
            <begin position="14"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="161"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="415"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="510"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="domain" description="YTH" evidence="9">
        <location>
            <begin position="1136"/>
            <end position="1259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00060772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAB0800905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1281" mass="146056" checksum="C1DF070233E64CB0" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AVY4</accession>
    <name>A0A5N4AVY4_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_02985</name>
        <name evidence="2" type="ORF">PPYR_05848</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000003">
        <property type="protein sequence ID" value="KAB0801494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AVY4"/>
    <dbReference type="InParanoid" id="A0A5N4AVY4"/>
    <dbReference type="OrthoDB" id="641149at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050390">
        <property type="entry name" value="C5-Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23068:SF25">
        <property type="entry name" value="DNA (CYTOSINE-5)-METHYLTRANSFERASE DRM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23068">
        <property type="entry name" value="DNA CYTOSINE-5- -METHYLTRANSFERASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0791185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0801494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="348" mass="39235" checksum="3C0AD47FF2D126CB" modified="2020-02-26" version="1">MCESGYCGKAYCVHCVDDFFKAGTWESFTGEEKWICFLCTRQEQVGVLSIRPDHILRIDKMFDEGNQIPLVNAPSISGSKIRVLSLFDGISTGFFALSKLGIEMDAYYASETDKGCINVSAHSSSGKVINVGDITSITEEDVKRMSPIHLVIGGPPCIEADLDNRKAKESVDFDGMFHPFLEFYRILCLVSKCNENGFYWLYENVTPEGLSPKDLINRYLQCEPFMQDTIYVSPQHKERLFWGNLPLQLHTIAVRRNNMQGDLLSCQSATSSQKVISERISCDSPISDEQNNNSSEFIAELEKILGFTVSNFNIWNMSATQRKRALQAARSIPVIMYLFTPFQQICVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AXV1</accession>
    <name>A0A5N4AXV1_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_04299</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AXV1"/>
    <dbReference type="InParanoid" id="A0A5N4AXV1"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0802113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="130" mass="15151" checksum="28363DA375BE4D8B" modified="2020-02-26" version="1">MRVWCEEDGELEQSDDSEESEEIKRNGDDTGLVQLARVSHVIWMQRKETDVVQLNNPQNGQWNKFASKQQSKKRKATLYCSGTSSHAKINRNNVQNFLRKHAYRSDKANKNCTDIAFICNTLHYLMFLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AYC8</accession>
    <name>A0A5N4AYC8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_04525</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AYC8"/>
    <dbReference type="InParanoid" id="A0A5N4AYC8"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33939:SF1">
        <property type="entry name" value="DUF4371 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33939">
        <property type="entry name" value="PROTEIN CBG22215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0802339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="318" mass="36712" checksum="2F4E6EDC6CF1AA45" modified="2020-02-26" version="1">MDATEAKQKNHGGVLTSVMAVQQRTADAVQVSKQTVVRTCAMREIGSDLKRNPYRRSKPRRTDLLENKKHTIRYLIYDMYANKEHVTLDTLLAVIKLKDLCDLGRTSLFYALKEMGFKFKMTNSRRGSCEQSHVVSMRNVFLRKYIRNLESEIPHDFFATTHKASDGKRYIIIHAGGRNGFIEGSSLIFSSTNKSFDYHDNMNAELFEKWFEESFLKKLAQPSIIVLDNASYHTRKSEKIPRASSTKEEISNWLKMKNRPFAKVTPDVWNRCVTHTEEIIKDTFNREKIIDDVRALVFTVTTGSDEESDYLSESDNDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AYJ1</accession>
    <name>A0A5N4AYJ1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Zinc finger protein 865</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PPYR_04618</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">1611_PpyrPB1</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AYJ1"/>
    <dbReference type="InParanoid" id="A0A5N4AYJ1"/>
    <dbReference type="OrthoDB" id="8113227at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000325">
        <property type="entry name" value="ZFP90 zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000145">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050589">
        <property type="entry name" value="Ikaros_C2H2-ZF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012934">
        <property type="entry name" value="Znf_AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404:SF114">
        <property type="entry name" value="KLUMPFUSS, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07776">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00868">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51915">
        <property type="entry name" value="ZAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZAD" evidence="14">
        <location>
            <begin position="27"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="181"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="211"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="238"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="267"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="295"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="323"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="351"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="377"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00068876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAB0802432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="411" mass="47784" checksum="3C0723EFECCFCB56" modified="2020-02-26" version="1">MCGYVPTKLVKIMETQISIDNLTNIKRVCRVCLTESKEMRKLNETFENMTIQEALQHTLSLKVILDEEYPSSICAVCSSLLKICYNFKLQFEASQGKLHKYFGKSETILESFQGAPSAQVELISKRGVYNLNDVFIVEDEDAHIPNYEGFLKNLGREITADFVPNTSLKLETAHRRCRNDAVCKDCNKSFSCSRYLKRHYKNMHLSKSDTFMCEVCGIITESKSKLHKHMHKQHSGRSKCEICQKCYFDANVLKLHMAAIHSKGRNLLCTICGKTFNYLSALTYHMRIHNDERNYKCTFCPRTFRMQCSLKRHLRTHTGIRPYQCSYCSKAFRSSGEVTCHEMIHTGFRPYHCKYCGKGFTKHFNLKVHLFNHKGPYVCELCDKSFIEQQFLKMHIEKIHLRLSKSNDMTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AZ07</accession>
    <name>A0A5N4AZ07_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_04750</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AZ07"/>
    <dbReference type="InParanoid" id="A0A5N4AZ07"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF269">
        <property type="entry name" value="NUCLEASE HARBI1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="8">
        <location>
            <begin position="94"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0802564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="355" mass="40005" checksum="F30AB9248BA0DC8D" modified="2020-02-26" version="1">MYFFLGFAADPDLNSFFCFANSLEYLGSGHTMKDLHIDYRIGLSSISNIIREVCASLWSRLKSACFPPLTKEFLAKSAEEFEARANFPNCVAAIDGKHIRMIKPAKSGSMNFNYKHYFSVLLLAACDSQYKFLYINVGAPGKSSDSTIFKNSKLYSQLKSGQIKMPPPRTISESRPTTVPYFLIGDEGFGLCDFLIRLFAGKYLPIGKKIFNYRLTRARRYIECTFGILSNKWRIFHRPLNVDEALTDSIVKTCCLLHNFVRERDGYQFEDTITVEGLVDNMAPDNSTRSQIAGNCSIALIKSSVFTLSPSISYIVKINTDDLTRVERCAIGGDANKLQRFELALVALLFSACWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AZI1</accession>
    <name>A0A5N4AZI1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">Phosphatidylinositol 3-kinase catalytic subunit type 3</fullName>
            <ecNumber evidence="1 8">2.7.1.137</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PPYR_04935</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12709"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58088"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.137"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:12710"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the PI3/PI4-kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.137" evidence="1 8"/>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AZI1"/>
    <dbReference type="FunCoup" id="A0A5N4AZI1">
        <property type="interactions" value="1771"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AZI1"/>
    <dbReference type="OrthoDB" id="67688at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034271">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034272">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016303">
        <property type="term" value="F:1-phosphatidylinositol-3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08397">
        <property type="entry name" value="C2_PI3K_class_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00870">
        <property type="entry name" value="PI3Ka_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00896">
        <property type="entry name" value="PI3Kc_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000002">
        <property type="entry name" value="Phosphatidylinositol 3-kinase catalytic subunit type 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000274">
        <property type="entry name" value="Phosphatidylinositol 3-kinase catalytic subunit type 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000002">
        <property type="entry name" value="Phosphatidylinositol 3-kinase catalytic subunit type 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.70">
        <property type="entry name" value="Phosphatidylinositol 3-kinase, accessory domain (PIK)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057756">
        <property type="entry name" value="PI3-kinase_type3/VPS34_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002420">
        <property type="entry name" value="PI3K-type_C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001263">
        <property type="entry name" value="PI3K_accessory_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042236">
        <property type="entry name" value="PI3K_accessory_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008290">
        <property type="entry name" value="PI3K_Vps34"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048:SF7">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00792">
        <property type="entry name" value="PI3K_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00613">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000587">
        <property type="entry name" value="PI3K_Vps34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00142">
        <property type="entry name" value="PI3K_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00145">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51547">
        <property type="entry name" value="C2_PI3K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51545">
        <property type="entry name" value="PIK_HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="C2 PI3K-type" evidence="12">
        <location>
            <begin position="16"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="PIK helical" evidence="11">
        <location>
            <begin position="282"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="10">
        <location>
            <begin position="647"/>
            <end position="913"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR000587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAB0802749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="929" mass="107248" checksum="007CAC25E5BA7031" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B2B8</accession>
    <name>A0A5N4B2B8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_00705</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B2B8"/>
    <dbReference type="FunCoup" id="A0A5N4B2B8">
        <property type="interactions" value="124"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4B2B8"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF16">
        <property type="entry name" value="JERKY PROTEIN HOMOLOG-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="3">
        <location>
            <begin position="6"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0803735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="259" mass="29916" checksum="6F2FA20C5EF4A2D0" modified="2020-02-26" version="1">MLKPSKKCTLKKSENPKLEKQLYSWFLKQREHNLPISGEMIKQKALMIGKNLNIPTFTASEGWLHRFKSRHGVRFLKITGERDAILHLSSAWDKLTPATIKKCWNVVMPNNDVSDNAADDPDDEVPLNILQQRWRNENVDMRSVVRDTISLLDEVAPAEYEFTDVEVWNEDLNQENTIEVEDESDSSEEEENEPPIVKIAHGAVLKALDTTIEWSKQNAIHISDLMVLKKIHEKAVMAKISQKRQQTKIQDYFSKEIPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B304</accession>
    <name>A0A5N4B304_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PPYR_00750</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B304"/>
    <dbReference type="FunCoup" id="A0A5N4B304">
        <property type="interactions" value="34"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4B304"/>
    <dbReference type="OrthoDB" id="432970at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034451">
        <property type="term" value="C:centriolar satellite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036159">
        <property type="term" value="P:inner dynein arm assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044458">
        <property type="term" value="P:motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036158">
        <property type="term" value="P:outer dynein arm assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052298">
        <property type="entry name" value="ZMYND10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13244">
        <property type="entry name" value="ZINC FINGER MYND DOMAIN CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13244:SF7">
        <property type="entry name" value="ZINC FINGER MYND DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="382"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0803780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="421" mass="48073" checksum="45C8CCDB6E3F198F" modified="2020-02-26" version="1">MDSILLSTEIDLYIDTMKAQDMASLGSKSWLEWHQRLQKLNQEALIEAAAVKEEYVQEALVSFGKIMILVHEAILSNVWKRKVLPLLLRMENDPPCTFVAYSVLYHEAVCVALLELVTYHANAAQALGDAAADLLHYSYGTVSQLLVLKENSENEDNSKVELIRQRDDLAFDIGIRSLTILRYLGDCLDRLPLAVTARMFGIDDVPVLLTQMLVERPWIRKGKQYVGGKWMDWDGESVAKVEAQVWLALRQLLLDPSCPSHYNITDARRRQLMRLQQFLTPVLIDQISPLIELQQWVYRLSVADQPCAPPVPILLEVMLEIQDRIMATCEGKWKKIARQQLPQIFSKNHDDIVQTAQCLSEAYNAELLEKLEDINKKPEKSCVKCGKGAMQRCSRCKSIWYCSRNCQVTHWSTHKDDCNAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B349</accession>
    <name>A0A5N4B349_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">threonine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Threonyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PPYR_00943</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Thr) + L-threonine + ATP = L-threonyl-tRNA(Thr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24624"/>
            <dbReference type="Rhea" id="RHEA-COMP:9670"/>
            <dbReference type="Rhea" id="RHEA-COMP:9704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78534"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.3" evidence="3"/>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B349"/>
    <dbReference type="FunCoup" id="A0A5N4B349">
        <property type="interactions" value="1771"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4B349"/>
    <dbReference type="OrthoDB" id="5423599at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006435">
        <property type="term" value="P:threonyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01667">
        <property type="entry name" value="TGS_ThrRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00860">
        <property type="entry name" value="ThrRS_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00771">
        <property type="entry name" value="ThrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000009">
        <property type="entry name" value="Threonine--tRNA ligase 2, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000003">
        <property type="entry name" value="Threonine--tRNA ligase 2, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000006">
        <property type="entry name" value="Threonine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.980.10:FF:000003">
        <property type="entry name" value="Threonine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.980.10">
        <property type="entry name" value="Threonyl-trna Synthetase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00184">
        <property type="entry name" value="Thr_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002320">
        <property type="entry name" value="Thr-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047246">
        <property type="entry name" value="ThrRS_anticodon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033728">
        <property type="entry name" value="ThrRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00418">
        <property type="entry name" value="thrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451:SF46">
        <property type="entry name" value="THREONINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451">
        <property type="entry name" value="THREONINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01047">
        <property type="entry name" value="TRNASYNTHTHR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="ThrRS/AlaRS common domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TGS" evidence="13">
        <location>
            <begin position="59"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="12">
        <location>
            <begin position="329"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAB0803973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="700" mass="80488" checksum="3F76C51088FC1653" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-09-13" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B4G6</accession>
    <name>A0A5N4B4G6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_01220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B4G6"/>
    <dbReference type="InParanoid" id="A0A5N4B4G6"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0804250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="106" mass="12459" checksum="3A42C7A9E07FE1B7" modified="2020-02-26" version="1">MFDICSDSVSKIATKLDRIKKRYQEIIDLIFRWVPSHAGLKGNEEIGQVVRLATYLRTHNNRATHPDLKKHLHLRTNEFWIPSGYSTVQQKLHKSEMVSTHKDKYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B4U9</accession>
    <name>A0A5N4B4U9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Splicing factor 3B subunit 5</fullName>
            <shortName evidence="2">SF3b5</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_01611</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the SF3B5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B4U9"/>
    <dbReference type="FunCoup" id="A0A5N4B4U9">
        <property type="interactions" value="558"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4B4U9"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009846">
        <property type="entry name" value="SF3b5/RDS3-10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017089">
        <property type="entry name" value="Splicing_factor_3B_subunit_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20978">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20978:SF0">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07189">
        <property type="entry name" value="SF3b10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037010">
        <property type="entry name" value="Splicing_factor_3B_subunit_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="2" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0747">Spliceosome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR037010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0804641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="85" mass="9819" checksum="46745C8325B7C3B6" modified="2020-02-26" version="1">MGDRYNIHSQLEHLQSKYIGTGHADTTKYEWLVNQHRDSCSSYLGHPDLLNYFAIAENEAKARVRFNIMEKMLQPCGPPPDKPED</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B6F1</accession>
    <name>A0A5N4B6F1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Double jelly roll-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_02157</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0805187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B6F1"/>
    <dbReference type="InParanoid" id="A0A5N4B6F1"/>
    <dbReference type="OrthoDB" id="6761856at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049512">
        <property type="entry name" value="DJR-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36159">
        <property type="entry name" value="PROTEIN CBG23766"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36159:SF1">
        <property type="entry name" value="RETROVIRUS-RELATED POL POLYPROTEIN FROM TRANSPOSON 412-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21738">
        <property type="entry name" value="DJR-like_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Double jelly roll-like" evidence="1">
        <location>
            <begin position="73"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0805187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="399" mass="45821" checksum="557F2D655FB89D7F" modified="2020-02-26" version="1">MEEALKNLFSSVKYEDMIVECDRRTYHPYSTNAYGNSDEINLVIQKADLITATYDSVIYLEGTLTSSEAKQFELTNNAPLFLFDEIRFTLGDQVIEIVRLPGINSAIKGFCSYTTDQSNCLSQAGWSPRNKPLQLLNANKTAFCASIPLKHVLGFAEGYKKPLVNIRQELTLIRSKTDEDCYKSEAEVKISLSKVTWKVPYVIPNDSMKLSIYSRIDKNVPIQVAFHARDLYAYPALPSTRSLVWPVKSSTGFQRPQWLLVAFQTKKRNQKGENASQFDHLGVENIKANINNRRYPYEQQNLSFADNKYIDAYEEYLNFRTQYYDSESSSLLSYEEFKKQPIFVINCTRHNESIHNVVIDLKLEVETSEAFAADTSAYCIILHDVLIEYEPFTNIVRKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B7A3</accession>
    <name>A0A5N4B7A3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_02393</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0805423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B7A3"/>
    <dbReference type="InParanoid" id="A0A5N4B7A3"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47510:SF3">
        <property type="entry name" value="ENDO_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47510">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="102"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0805423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="629" mass="73166" checksum="8CFB2331CD5BA7B2" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B7G4</accession>
    <name>A0A5N4B7G4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphorylated adapter RNA export protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">RNA U small nuclear RNA export adapter protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PPYR_02458</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PHAX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0805488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B7G4"/>
    <dbReference type="FunCoup" id="A0A5N4B7G4">
        <property type="interactions" value="1289"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4B7G4"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006408">
        <property type="term" value="P:snRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1440:FF:000001">
        <property type="entry name" value="phosphorylated adapter RNA export protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1440">
        <property type="entry name" value="PHAX RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039047">
        <property type="entry name" value="PHAX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019385">
        <property type="entry name" value="PHAX_RNA-binding_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038092">
        <property type="entry name" value="PHAX_RNA-binding_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13135">
        <property type="entry name" value="CYTOSOLIC RESINIFERATOXIN BINDING PROTEIN RBP-26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13135:SF0">
        <property type="entry name" value="PHOSPHORYLATED ADAPTER RNA EXPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10258">
        <property type="entry name" value="PHAX_RNA-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Phosphorylated adapter RNA export protein RNA-binding" evidence="12">
        <location>
            <begin position="232"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="97"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="362"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="97"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="383"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF10258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAB0805488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="428" mass="48941" checksum="D18A87387B9AD896" modified="2020-02-26" version="1">MTIVFLYKKSSSVIGGYLHRTVHFPQKTKLKCLTLKELITFINSILCTLITQIMDAEEPLEEGEILDTSLHEYTPLERPPNYSELFAARFPPIQDAESEEEFESTSESDSDDGGKKLKRPKLKLKPQAVSSKSNFRKKYDIWSTRVQEDLLLENLVNCDVSQVDRSRSVETYSKNYVPFLTSNKRTNSDRYKVNLRLPKKSRHTDEDSETVQATARVILDVHATVEDSEDDIAKDIANKLFEEKEDLIKTIVATAGKAKALELFKETQRIEKGGGMMIMNQTRRRTPGGVFLFLVKHDNNITREQMMTIFNEERMKYKQEVRLKRKLKLQQIKQKIAASKRNCEQNLPELLTRAELCAKNQERTKKETQDVIVKNPPPSPVTDGHDNSTDGMENAKDTDVTTESCVLGRSIVSYDDDCIDVGADMDLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B7I3</accession>
    <name>A0A5N4B7I3_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_02478</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0805508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B7I3"/>
    <dbReference type="InParanoid" id="A0A5N4B7I3"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024347995" evidence="2">
        <location>
            <begin position="17"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0805508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="101" mass="11311" checksum="B1BA808F91820F61" modified="2020-02-26" version="1">MRTTVLLLLLLSVVIAQRPGYLGGLPAGYPALASRFKEENSSPDPTSSAPISPTPAPVSNPPAPPSDVKFYYKPTNVHYPHWYPTKYHYKDVEYNDQFIFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B7W7</accession>
    <name>A0A5N4B7W7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_02669</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0805699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B7W7"/>
    <dbReference type="InParanoid" id="A0A5N4B7W7"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0805699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="105" mass="12396" checksum="A1A4A525BCBDF51A" modified="2020-02-26" version="1">MTRVQNHVKVRYFATGMSFRSLAFTFRVDHYTIGKLVEEVCDALWIKLRATHLGVPNQDRFRQISSKFNARWNFPNCIGCVDGKHIEIKCPPKSGTMYYNYKHFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B7X0</accession>
    <name>A0A5N4B7X0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Guanine nucleotide-binding protein G(s) subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Adenylate cyclase-stimulating G alpha protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PPYR_02430</name>
        <name evidence="15" type="ORF">PPYR_02438</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein-coupled receptors (GPCRs).</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 12">G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the G-alpha family. G(s) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0805460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0805468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B7X0"/>
    <dbReference type="FunCoup" id="A0A5N4B7X0">
        <property type="interactions" value="452"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4B7X0"/>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007191">
        <property type="term" value="P:adenylate cyclase-activating dopamine receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007606">
        <property type="term" value="P:sensory perception of chemical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000720">
        <property type="entry name" value="Guanine nucleotide-binding protein G(k) subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.400.10:FF:000003">
        <property type="entry name" value="Guanine nucleotide-binding protein G(S) subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:006178">
        <property type="entry name" value="Guanine nucleotide-binding protein G(s) subunit alpha isoforms short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000367">
        <property type="entry name" value="Gprotein_alpha_S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF212">
        <property type="entry name" value="G PROTEIN ALPHA S SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00443">
        <property type="entry name" value="GPROTEINAS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10 12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 11 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 10 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0564">Palmitate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0807">Transducer</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="52"/>
            <end position="57"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="185"/>
            <end position="191"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="210"/>
            <end position="214"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="279"/>
            <end position="282"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="353"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU369121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAB0805460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAB0805468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="381" mass="44496" checksum="85723FF570C08624" modified="2020-02-26" version="1">MGCFGNRESQQTAGGDDSRSQKRISDQINRQLQKDKQVYRATHRLLLLGAGESGKSTIVKQMRILHVNGFSETERKQKIEDIKKNVRDAILTITGAMSTLTPPVALEHAENQARVDYIQDYASGPDFDYPPEFYEYTEALWKDRGVQTTFDRSNEYQLIDCAKYFLDRVETIKLPDYTPTEQDILRCRVLTSGIFETRFQVDKVNFHMFDVGGQRDERRKWIQCFNDVTAIIFVTACSSYNMVLREDPTQNRLRESLDLFKSIWNNRWLRTISVILFLNKQDLLSEKILAGKSKLEDYFGEFTRYQTPLDAPADTSEPPEVMRAKYFIRDEFLRISTASGEGKHYCYPHFTCAVDTENIKRVFNDCRDIIQRMHLRQYELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B9K1</accession>
    <name>A0A5N4B9K1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_02670</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0805700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B9K1"/>
    <dbReference type="InParanoid" id="A0A5N4B9K1"/>
    <dbReference type="OrthoDB" id="2415966at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF85">
        <property type="entry name" value="GH03217P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="8">
        <location>
            <begin position="157"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0805700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="366" mass="41839" checksum="54407EA1BBC1EB7D" modified="2020-02-26" version="1">MADGFILLIDAFVEDEQRNNAALIRRNLRDQSDPMSMPETQFRSLYRLSRKMVHNLILELSPHLQDAEREELFIPKKLKIMVALHFFAHASYQKAVGQDFCTSMSQSSVSKCLTVVVNALENLYHYVRFPQTQEEVTLVKQGFMNMAHGFPGIVGAVDCTHIAIVAPPINHPDYPAILFYNRKGYYSLNVQIICDANLKILALNARYPGSVHDAAIWGTSQIRQNLYNSYQAGHTSYLLGDSGYPLEPWLMTPITAPDTDAKRAYNIAHRSVRNVIERLNGVLKTRFRCLLKHRVLHYSPPVAAKIVNSCAVLHNMCILHGDQALIDDVPEDEYVQDEHDQQQLQNGHERYQGEQVRTRIVRMYFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1K2J5</accession>
    <name>A0A1Y1K2J5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WD repeat-containing protein 79</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_13616</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TCAB1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01099984">
        <property type="protein sequence ID" value="JAV53077.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1K2J5"/>
    <dbReference type="FunCoup" id="A0A1Y1K2J5">
        <property type="interactions" value="1677"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1K2J5"/>
    <dbReference type="OrthoDB" id="239865at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015030">
        <property type="term" value="C:Cajal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030576">
        <property type="term" value="P:Cajal body organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051150">
        <property type="entry name" value="SWT21/TCAB1_mRNA_Telomere"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13211">
        <property type="entry name" value="TELOMERASE CAJAL BODY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13211:SF0">
        <property type="entry name" value="TELOMERASE CAJAL BODY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="227"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="282"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00041558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="JAV53077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0793996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="392" mass="43170" checksum="AF2E34C3A74A5B9A" modified="2017-08-30" version="1">MSTFEGSSVGYVNYNFQSTTLELARCQWANYSDQHYLKCCKWSPDGTCLLTIARGAGTHVVELPSDLYTGESMLTSRPVNPLSPAVSVPENGLIYDYSWYPGMNSSNPATCCWVASGHEGPIHLWDAFTGDLRCTYRGYNNVDELEAAISVTFSADGQNIFCGYKKNVKIFSTSRPGREYLEYATQHPASCIVSSIAQPGVVAIGTWKNTVELVSQSDGTFRHLCKLTGHKGGITAMAFSMDGMRLYTGARKDNEIICWDLRVPGRPLFCLGRQCNTNQKIAIDLSSDGRWLVSGGTDGKVQVWDVSQSVAPTVHMELPLHTDCCNGVSLHPYRPILASSSGQHHTLDPLHHTRSVLVYENALIMWWVGPQQEDPDFVGTYLKVSSGNTSNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1KB83</accession>
    <name>A0A1Y1KB83_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">ADP-ribosylation factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PPYR_11868</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">1611_PpyrPB1</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">1611_PpyrPB1</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01091879">
        <property type="protein sequence ID" value="JAV56726.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0795029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1KB83"/>
    <dbReference type="FunCoup" id="A0A1Y1KB83">
        <property type="interactions" value="2600"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1KB83"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051649">
        <property type="term" value="P:establishment of localization in cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04150">
        <property type="entry name" value="Arf1_5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003500">
        <property type="entry name" value="ADP-ribosylation factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045872">
        <property type="entry name" value="Arf1-5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 15" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 15" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 12 14" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10 15" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 15" id="KW-0519">Myristate</keyword>
    <keyword evidence="5 12 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 15" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 15" id="KW-0813">Transport</keyword>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="126"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU369003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="JAV56726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAB0795029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="182" mass="20678" checksum="B8A4E76A01F06603" modified="2017-08-30" version="1">MGNMFANLFKGLFGKKEMRILMVGLDAAGKTTILYKLKLGEIVTTIPTIGFNVETVEYKNISFTVWDVGGQDKIRPLWRHYFQNTQGLIFVVDSNDRERIGEAKDELMRMLAEDELRDAVLLIFANKQDLPNAMNAAEITDKLGLHSLRNRNWYIQATCATSGDGLYEGLDWLSNQLKNANR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1KIB5</accession>
    <name>A0A1Y1KIB5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">H15 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_11774</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01083398">
        <property type="protein sequence ID" value="JAV61114.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0794935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1KIB5"/>
    <dbReference type="InParanoid" id="A0A1Y1KIB5"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="JAV61114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0794935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="215" mass="24583" checksum="EE61BC3B67AA2950" modified="2017-08-30" version="1">MASNSSYLREIIRAIKVLDKEDGVTMKDLTRYLTPRVCKRYRNRKYAMLGVCAALRRGVESGNINVKPERYFLKRHASLIDTSSSSSYSSVDDGTRSKIKSSDSGDRLPATFTHQNSPKKVKQEETVHEVEVVSHTQVPKNSIDHIETFDDTNNSNNDDDDIKNVPQEETTVHEVEVLVHTVENKNSIDYIEQFERTRNSNNDDRDIALSLMYIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1KL93</accession>
    <name>A0A1Y1KL93_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PPYR_10570</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01080399">
        <property type="protein sequence ID" value="JAV62173.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1KL93"/>
    <dbReference type="InParanoid" id="A0A1Y1KL93"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000551">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24355">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR KINASE/RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24355:SF1">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="84"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="JAV62173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0796509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="253" mass="29008" checksum="B86AAC0D6F872D93" modified="2017-08-30" version="1">MGNSNCKPNALNVYKSNENIEVTKATQKRQFSVTVDSENQLPKLQPRYIAVKNERRKTVWPFTQLIQIFMPDFRYNSSTLDNNFTVFGEIGSGSFGRVYKVQELKTNSIFALKVLPKSQVIQDEAVHQVKNEVRIQSICGHHTFIINSPYHWQSRSHLYIVTDFAERGELFKLLEAYSILPTPVTKLYIAEIALALDFLHNAGIIHRDLKPENILLDSEGHIQITDFGLAKWVAYGCTTRRVCGTFEYMGMML</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1KN97</accession>
    <name>A0A1Y1KN97_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_10282</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
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                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
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        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
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                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
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                <person name="Sander Lower S.E."/>
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                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
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                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
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                <person name="Schmitz R.J."/>
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                <person name="Shigenobu S."/>
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        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
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                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FUN14 family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01078455">
        <property type="protein sequence ID" value="JAV62696.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01078454">
        <property type="protein sequence ID" value="JAV62697.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01078453">
        <property type="protein sequence ID" value="JAV62699.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01078452">
        <property type="protein sequence ID" value="JAV62700.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01078451">
        <property type="protein sequence ID" value="JAV62702.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1KTF7"/>
    <dbReference type="InParanoid" id="A0A1Y1KTF7"/>
    <dbReference type="OrthoDB" id="163794at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007014">
        <property type="entry name" value="FUN14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21346">
        <property type="entry name" value="FUN14 DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21346:SF0">
        <property type="entry name" value="RE45833P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04930">
        <property type="entry name" value="FUN14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="JAV62696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0802439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="123" mass="12950" checksum="155CA299FEFBE040" modified="2017-08-30" version="1">MCRGQAAKGLLTKLPHLISKSSGLAQLGVGTVTGLTTGCVMSKLGKTAVAVTGTGILLAQVAHSQGWGSMDWKKIKTKAHETTKAIDTKYHNTKFSSNMKEFSQTNPYFTAGFVGGFLIGMGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1KX04</accession>
    <name>A0A1Y1KX04_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_06944</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01075176">
        <property type="protein sequence ID" value="JAV64225.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1KX04"/>
    <dbReference type="FunCoup" id="A0A1Y1KX04">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1KX04"/>
    <dbReference type="OrthoDB" id="8188991at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1250">
        <property type="entry name" value="Sulfhydryl oxidase R596, ORFan domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="JAV64225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0799064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="243" mass="27803" checksum="8BB26871526F1F9E" modified="2017-08-30" version="1">MSEKTSPDTVPGLGFKDKEKAFETLKLLEGRDPDYQRLAIKGLIGRAKRTLTLTKAEDKLQNIKDAMEVFDKWLQNFEDMNLGKENKAYLPLPSIKVLSSLFKKYDVQDKLAKEFLEAYKKVGGEYKHLRTVSSGENEPTWDIVRNSQLKNILKDIEENKPDMWDDGLPTEEHLRLIAWAYSPEASHIKKNLSKMEEKLKGDDSMDDEGSEEEESPKKNSSKRKSSSGSESSEEETPKKKSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1KXZ4</accession>
    <name>A0A1Y1KXZ4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Solute carrier family 25 member 44</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PPYR_08095</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01074408">
        <property type="protein sequence ID" value="JAV64565.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1KXZ4"/>
    <dbReference type="FunCoup" id="A0A1Y1KXZ4">
        <property type="interactions" value="1800"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1KXZ4"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015658">
        <property type="term" value="F:branched-chain amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009083">
        <property type="term" value="P:branched-chain amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042164">
        <property type="entry name" value="SLC25A44"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46314">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 MEMBER 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46314:SF2">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 MEMBER 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="7">
        <location>
            <begin position="21"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="7">
        <location>
            <begin position="113"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="7">
        <location>
            <begin position="224"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="JAV64565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0797101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="318" mass="36405" checksum="4B67286A4FA5B005" modified="2017-08-30" version="1">MMAMVETPPPDFIKTIEWDMMDKTKFFPLSMLSSFSIRCALYPLTLIKTRLQIQKQNVLYRGMIDAYIKIFRKEGFSGLYKGFWVSSVQIVSGVFYISTYEGVRYSLAQKNIDSRFRSLMAGGVASAVSQTIIVPFDVVSQHLMMLGALDSKEAFYIKEDIMRKGKFAVTSEIVRQIFRCDGIAGFYRGYTASLCAYVPNSALWWAFYHFYQDQLHVILPSWISHLLIQTVSGTLGGFSTTIITNPLDVVRARLQVQRLESISGAFKDLWHEEGLKMFSKGLSARLVQSATFSFSIILGYETIKRISVNEEYKQFIRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1L2F7</accession>
    <name>A0A1Y1L2F7_PHOPY</name>
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            <taxon>Coleoptera</taxon>
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            <taxon>Elateroidea</taxon>
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            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
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            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
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    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01066609">
        <property type="protein sequence ID" value="JAV67764.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
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    </dbReference>
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        </source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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        </source>
    </evidence>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
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                <person name="Al-Wathiqui N."/>
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            <dbReference type="DOI" id="10.1038/srep38556"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
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        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
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            <dbReference type="PubMed" id="30324905"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1L6K7</accession>
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            <taxon>Elateroidea</taxon>
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            <taxon>Photinus</taxon>
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    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
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            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="15" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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        </source>
    </reference>
    <comment type="subunit">
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
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    </evidence>
    <sequence length="157" mass="18524" checksum="1E0370B7BD36F4E2" modified="2017-08-30" version="1">MMQFMLLFSRQGKLRLQKWYVAHPDKLKKKITRELITTILARKPKMCSFLEWKDLKVVYKRYASLYFCCAIEQDDNELLTLEVIHRYVELLDKYFGSVCELDIIFNFEKAYFILDELLLGGEIQETSKKNVLKAIAAQDLLQEEETPQGFFEDHGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Photinus pyralis</name>
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            <taxon>Neoptera</taxon>
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            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
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            <taxon>Lampyrinae</taxon>
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    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
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                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
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            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">1611_PpyrPB1</strain>
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    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">1611_PpyrPB1</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
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            <begin position="2608"/>
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            <begin position="130"/>
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        <location>
            <begin position="1813"/>
            <end position="1935"/>
        </location>
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            <begin position="2666"/>
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        </location>
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        </location>
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        </location>
    </feature>
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        </location>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
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        <location>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="JAV70554.1"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAB0799954.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LB74</accession>
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        <recommendedName>
            <fullName evidence="15">Myosin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="13" type="ORF">PPYR_13144</name>
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    <organism evidence="12">
        <name type="scientific">Photinus pyralis</name>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
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            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
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        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
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                <person name="Lewis S.M."/>
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            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
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                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
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                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
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                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
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            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
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        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Photinus pyralis genome working group"/>
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                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
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        <property type="term" value="P:imaginal disc-derived male genitalia morphogenesis"/>
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        <property type="entry name" value="UNCONVENTIONAL MYOSIN ID"/>
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    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
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        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="MYOSIN_MOTOR"/>
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    </dbReference>
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        <property type="entry name" value="TH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0009">Actin-binding</keyword>
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    <keyword evidence="5" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="7 9" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6 9" id="KW-0518">Myosin</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin motor" evidence="10">
        <location>
            <begin position="7"/>
            <end position="693"/>
        </location>
    </feature>
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        <location>
            <begin position="810"/>
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        <location>
            <begin position="570"/>
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        <location>
            <begin position="100"/>
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        <ligand>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
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    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
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        <source>
            <dbReference type="PROSITE" id="PS51757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="JAV70873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAB0793524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1013" mass="116290" checksum="7436FEF184B75AAE" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LPS5</accession>
    <name>A0A1Y1LPS5_PHOPY</name>
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        <recommendedName>
            <fullName evidence="10">Protein charybde</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PPYR_13643</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Inhibits cell growth by regulating the Tor pathway upstream of the Tsc1-Tsc2 complex and downstream of Akt1. Acts as a cell death activator during head development.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DDIT4 family.</text>
    </comment>
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        <property type="protein sequence ID" value="JAV72987.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KAB0794023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="10018535at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008258">
        <property type="term" value="P:head involution"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045926">
        <property type="term" value="P:negative regulation of growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009968">
        <property type="term" value="P:negative regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032006">
        <property type="term" value="P:regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.470.40:FF:000003">
        <property type="entry name" value="Charybde, isoform E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.40">
        <property type="entry name" value="RTP801-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012918">
        <property type="entry name" value="RTP801-like"/>
    </dbReference>
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        <property type="entry name" value="RTP801-like_C_sf"/>
    </dbReference>
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        <property type="entry name" value="DNA-DAMAGE-INDUCIBLE TRANSCRIPT 4 PROTEIN DDIT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12478:SF16">
        <property type="entry name" value="PROTEIN CHARYBDE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07809">
        <property type="entry name" value="RTP801_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00059352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="JAV72987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0794023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="205" mass="22882" checksum="9647167EF1754F8B" modified="2017-08-30" version="1">MFRKKDERVQSDSKLHAVFSKLTGVFPRAADLNNATTHKMSSDIIESVLTDVPIPQPQHLDCDSQCTSDDNCEVAINALSKRLETELRQAKSTSLGCCEVLLPCGLLQRISKDIIAMAESEPCGLRGCTLYLNFEGLEECRRLSIIKCDPTTASTFELYLTLKQAPSGWNSFLPQFLRNLTRGGTIVISPAYILSKNKLYRSYIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LXV5</accession>
    <name>A0A1Y1LXV5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">G-protein coupled receptors family 2 profile 2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PPYR_14485</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 2 family. Mth subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01046505">
        <property type="protein sequence ID" value="JAV77180.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1LXV5"/>
    <dbReference type="FunCoup" id="A0A1Y1LXV5">
        <property type="interactions" value="151"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1LXV5"/>
    <dbReference type="OrthoDB" id="6134459at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15039">
        <property type="entry name" value="7tmB3_Methuselah-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.180.11">
        <property type="entry name" value="Methuselah ectodomain, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023311">
        <property type="entry name" value="Methusela_ecto_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036272">
        <property type="entry name" value="Methuselah_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051384">
        <property type="entry name" value="Mth_GPCR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47154">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR MTH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47154:SF2">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR MTH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63877">
        <property type="entry name" value="Methuselah ectodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033289897" description="G-protein coupled receptors family 2 profile 2 domain-containing protein" evidence="11">
        <location>
            <begin position="21"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="220"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="398"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="433"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="12">
        <location>
            <begin position="186"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="JAV77180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAB0792526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="489" mass="56106" checksum="AD978A4E41B2ABC5" modified="2017-08-30" version="1">MTYLFIFAISLNLIIASLSSVCVPDTRQRSDDLAPDGNSYSAVFFNKSYTSDCGCDSKYTCVRKCCDEGYFIDLNEETLELKCLRNDSIKLSVPIYKMGNVIIDNNPIIDFRYLSGVNECLLDDDDKNAYTATMDEFYIQKNGKLWMSSLNTYFKPEHYCLEYDEDNGPIAYLCLLSYDVQSLEISSRITVIGMMISLPFLLVTFIVYGVLPLRNLHGKALMCYIFSLFTTYLLYIIIQLHPDAESLDAVLCKTLAMIFMYFFEASFVWMNVMCIDIYLTFSGIKLIISERRRIESRRFIYYSIYAWGAPLLLLILVIVMSNSVKPNAWYNPGISDQQCWLNDGIPTLLYLYLPMAILIITNVILFVITAHKVRVASRATAMLRTGDNRSSNDDTVRLGVYVKLFLCMGVNWALEIVTWAIDWQVENVPRALWYVADLCNALFGLLIFIIFVCNKKVWKLMKIKYYEVTGKTPPTAVSSTDEVTLEKYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LY15</accession>
    <name>A0A1Y1LY15_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">ER lumen protein-retaining receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PPYR_13224</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERD2 family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01044993">
        <property type="protein sequence ID" value="JAV77991.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1LY15"/>
    <dbReference type="FunCoup" id="A0A1Y1LY15">
        <property type="interactions" value="913"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1LY15"/>
    <dbReference type="OrthoDB" id="7694678at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046923">
        <property type="term" value="F:ER retention sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006621">
        <property type="term" value="P:protein retention in ER lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000133">
        <property type="entry name" value="ER_ret_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10585">
        <property type="entry name" value="ER LUMEN PROTEIN RETAINING RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00810">
        <property type="entry name" value="ER_lumen_recept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00660">
        <property type="entry name" value="ERLUMENR"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00951">
        <property type="entry name" value="ER_LUMEN_RECEPTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="91"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="JAV77991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAB0793604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="211" mass="24426" checksum="D7705CE1E78DF60D" modified="2017-08-30" version="1">MNIFRLVGDLSHLLAIIILLLKIWKTRSCAGISGKSQILFAIVYTSRYLDLPNFVSMYNTLMKIVFIAASYATVYLIYMKFKATYDHNHDTFRVEFLVLPSFVLALLINHDFTVLEVLWTFSIYMESVAILPQLFMVSKTGEAESITSHYLFALGSYRALYILNWIYRYTTEDHYDLIAIVAGIVQTVLYCDFFYLYITKVLKGKKLQLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LYK0</accession>
    <name>A0A1Y1LYK0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Deoxyribonuclease TATDN1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_06526</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Deoxyribonuclease which catalyzes (in vitro) the decatenation of kinetoplast DNA, which are circular DNA catenated to each other, producing linear DNA molecules. Plays an important role in chromosomal segregation and cell cycle progression during eye development probably via its DNA decatenation activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01043889">
        <property type="protein sequence ID" value="JAV78684.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000004">
        <property type="protein sequence ID" value="KAB0800787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1LYK0"/>
    <dbReference type="FunCoup" id="A0A1Y1LYK0">
        <property type="interactions" value="1397"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1LYK0"/>
    <dbReference type="OrthoDB" id="6079689at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01310">
        <property type="entry name" value="TatD_DNAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018228">
        <property type="entry name" value="DNase_TatD-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050891">
        <property type="entry name" value="TatD-type_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10060:SF15">
        <property type="entry name" value="DEOXYRIBONUCLEASE TATDN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10060">
        <property type="entry name" value="TATD FAMILY DEOXYRIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005902">
        <property type="entry name" value="DNase_TatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01090">
        <property type="entry name" value="TATD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00045223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR005902-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="JAV78684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0800787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="299" mass="34044" checksum="19D968644800E9B5" modified="2017-08-30" version="1">MTKFIDIGANLLDAMYTGVYNGSKKHEPDLKDVLHRSWSNGLNKIIITAGNLEESKNALSLSTSDERLYSTVGCHPTRCLEFEDNPEEYLAQLKDVASANRNKIVAIGECGLDYDRTQFCPIDVQKRYFEKQIHLAQSLNLPLFLHCRNAADDLYAILSKYQNLRGVVHSFDGTIDEANRFMELGYYIGLNGCSLKTKENLETVAQLPSNRVLLETDCPWCEIRPTHAGYGYVKEENRSHPSVKKEKWKADCLIKSRNEPMNIRQVLDVLAALKKEDPSEIGEVIYRNSEELFFENGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1M0Z4</accession>
    <name>A0A1Y1M0Z4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Anti-proliferative protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_01519</name>
        <name evidence="6" type="ORF">PPYR_11326</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BTG family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01045015">
        <property type="protein sequence ID" value="JAV77975.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0794487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1M0Z4"/>
    <dbReference type="FunCoup" id="A0A1Y1M0Z4">
        <property type="interactions" value="306"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1M0Z4"/>
    <dbReference type="OrthoDB" id="19928at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.90:FF:000001">
        <property type="entry name" value="TOB1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.90">
        <property type="entry name" value="Anti-proliferative protein, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002087">
        <property type="entry name" value="Anti_prolifrtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036054">
        <property type="entry name" value="BTG-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015676">
        <property type="entry name" value="Tob1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17537">
        <property type="entry name" value="TRANSDUCER OF ERBB2 TOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17537:SF5">
        <property type="entry name" value="TRANSDUCER OF ERBB2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07742">
        <property type="entry name" value="BTG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00310">
        <property type="entry name" value="ANTIPRLFBTG1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00099">
        <property type="entry name" value="btg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160696">
        <property type="entry name" value="BTG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Anti-proliferative protein" evidence="4">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="186"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="265"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="336"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="190"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="265"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="JAV77975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0794487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0804549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="375" mass="41501" checksum="8AF3BA15408F9D48" modified="2017-08-30" version="1">MHIEVQVALNFVISYLYNKLPRRRVNIFGEELEKALKDKFQGHWYPDKPFKGSAFRCIKTGDPVDKVLERAARESGVTIQDILENLPQELAVWVDPGEVSYRIGEKGAVKILFSEKGDPQDESSADREVTKTFNPEAQCFKPIDSVSSSLSNLSLSPKSSPFTSQAAITTPQVPANSIVQNANQNINHLSSPSSAPSPTSVGNSYKGSPSPVPSFIPRTTTPLTFTTATFAQTKFGSTKLKTSSKRANRMSPTEFSNYIKQRAMQQQMHQQQAQHHSPGGRALSPDPSAYYYSHGPYAHQFPHRSMFESSNQFLSADLYPGKLPFDHTPLGSYYPNNATMGAPTTTPNTPQDSNKLLDNWPYPSAGQYQHLLVAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1M5U5</accession>
    <name>A0A1Y1M5U5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Protein twisted gastrulation</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PPYR_11081</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
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        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="entry name" value="TWISTED GASTRULATION PROTEIN HOMOLOG 1-A-RELATED"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR12312:SF16">
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    </dbReference>
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        <location>
            <begin position="22"/>
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        </location>
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    </evidence>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
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            <authorList>
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                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
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            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
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    </reference>
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        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
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                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
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        </location>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
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            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
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            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
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            <dbReference type="PubMed" id="30324905"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">1611_PpyrPB1</strain>
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        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="16">1611_PpyrPB1</strain>
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        </source>
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        <property type="molecule type" value="Transcribed_RNA"/>
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        <property type="entry name" value="ZINC FINGER RAN-BINDING DOMAIN-CONTAINING PROTEIN 2 ZRANB2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00641">
        <property type="entry name" value="Zn_ribbon_RanBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037956">
        <property type="entry name" value="UCP037956_ZnF_Ran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RanBP2-type" evidence="14">
        <location>
            <begin position="21"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="14">
        <location>
            <begin position="76"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="108"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="148"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="170"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR037956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="JAV84275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAB0799668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="214" mass="24146" checksum="AA4B1254C404DC18" modified="2017-08-30" version="1">MAEAELTPPPPPNISGTLKISEGDWTCEDCGNVNFARRNACNRCSKERVPPAVSKRKKLGQEIGKAAAEKSRGLFSADDWQCNKCGNVNWARRQQCNVCNAPKFGEVEERTGLGGGYNDRGVVEYKERNDSDDEYDEFGRRKKRKSKSERSSSDEAEREVETKKKKVVEAAEDEDEEEDDGDLSKYDLSDWGVEPDVKSTRRKSRSRSRSPITK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1MJX6</accession>
    <name>A0A1Y1MJX6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serine-threonine kinase receptor-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_13688</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the WD repeat STRAP family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01029604">
        <property type="protein sequence ID" value="JAV86049.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0794068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1MJX6"/>
    <dbReference type="FunCoup" id="A0A1Y1MJX6">
        <property type="interactions" value="1618"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1MJX6"/>
    <dbReference type="OrthoDB" id="200206at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032797">
        <property type="term" value="C:SMN complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000133">
        <property type="entry name" value="Serine-threonine kinase receptor-associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19877">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19877:SF13">
        <property type="entry name" value="SERINE-THREONINE KINASE RECEPTOR-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="56"/>
            <end position="97"/>
        </location>
    </feature>
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        <location>
            <begin position="97"/>
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        </location>
    </feature>
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        <location>
            <begin position="140"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="263"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="JAV86049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0794068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="327" mass="35621" checksum="698B0B32F9B8E6A6" modified="2017-08-30" version="1">MANLRQTPLTCSGHTRPVVHLDFSAVTECGYFLISACKDGKPMLRQGDTGDWIGTFEGHKGAVWGVALNAQATKAASGAADFTGKVWDAVTGEELHSFQHNHIVKSVNFSKDSNFLATGSNEKLVRIFDLNKPDASPTVFSGHTAGVRHALFFRDDSHLISCADDKSLRVWDRVSGKEVQKLEFSAVPNSLEVSRDGSVITVTHSNNITFLDSGSLSKIREFPLPTTANSASLHPDKCIFVAGGDDFKMYKFDYTTGTEIESFKGHFGPVHCVRFSPDGELYASGSEDGTLRLWQTTVGKTYGLWKCVDGPQLNNEPLSPPREVSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1MTX4</accession>
    <name>A0A1Y1MTX4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Cyclic nucleotide-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="18" type="ORF">PPYR_07021</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
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        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">1611_PpyrPB1</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">1611_PpyrPB1</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GEZM01022962">
        <property type="protein sequence ID" value="JAV88637.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01022961">
        <property type="protein sequence ID" value="JAV88638.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1MTX4"/>
    <dbReference type="FunCoup" id="A0A1Y1MTX4">
        <property type="interactions" value="311"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1MTX4"/>
    <dbReference type="OrthoDB" id="447251at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.260:FF:000003">
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
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                <person name="Bessho-Uehara M."/>
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                <person name="Bewick A.J."/>
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                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
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                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
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                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
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                <person name="Sander Lower S.E."/>
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                <person name="Bessho-Uehara M."/>
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                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
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                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01012000">
        <property type="protein sequence ID" value="JAV93293.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01011999">
        <property type="protein sequence ID" value="JAV93295.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01011998">
        <property type="protein sequence ID" value="JAV93297.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01011997">
        <property type="protein sequence ID" value="JAV93300.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01011996">
        <property type="protein sequence ID" value="JAV93301.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01011995">
        <property type="protein sequence ID" value="JAV93303.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01011994">
        <property type="protein sequence ID" value="JAV93306.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01011993">
        <property type="protein sequence ID" value="JAV93307.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1N8U2"/>
    <dbReference type="InParanoid" id="A0A1Y1N8U2"/>
    <dbReference type="OrthoDB" id="417891at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000149">
        <property type="entry name" value="15-hydroxyprostaglandin dehydrogenase [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229:SF8">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="JAV93300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0796767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="272" mass="29875" checksum="29EC93AB98A42B37" modified="2017-08-30" version="1">MNAIYGKVALISGGAAGIGLHYAKELLRNGLRAVTLADVSEERGKHAVEELTKEFGGSRSLFVKTDVTDKEQFAEAFERTVDTFKNIDMLVNNAGIMNDAVWERQIGINFVGTIIGCILALHHYLPKYKTANEGIIVNVASTTGLEVFGAIPVYVATKHAVVGLTQSWGTESHYKRTQVRFLALCPGPTDTTLALDGLDKNLGPAYQDIFRESQPFVTLQGPEYVAKGLLHAIEHGENGSIWVVEDSEVPYEVVIPSREKLKIINYHDSELM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1N907</accession>
    <name>A0A1Y1N907_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_13605</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01010605">
        <property type="protein sequence ID" value="JAV93978.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1N907"/>
    <dbReference type="InParanoid" id="A0A1Y1N907"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007608">
        <property type="term" value="P:sensory perception of smell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23992">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.20">
        <property type="entry name" value="Pheromone/general odorant binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006170">
        <property type="entry name" value="PBP/GOBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036728">
        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11857">
        <property type="entry name" value="ODORANT BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01395">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00708">
        <property type="entry name" value="PhBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036029915" evidence="2">
        <location>
            <begin position="17"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="JAV93978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0793985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="133" mass="15379" checksum="BD824AC66857EAC3" modified="2017-08-30" version="1">MLKLVVLVSLFAASLASFKFNVDQKHVNSWKKLSVPHNVCLEKENISPERFDSALDNMDFPEDKHFKCLFHCFFEKLNFYNEAEGTYNHELMIEQISGLTKERANNCYTPRGPHDDCEHVFHGVKCAIKALEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1NC00</accession>
    <name>A0A1Y1NC00_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Peptidase M13 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PPYR_05947</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M13 family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01007017">
        <property type="protein sequence ID" value="JAV95474.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000004">
        <property type="protein sequence ID" value="KAB0800207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1NC00"/>
    <dbReference type="InParanoid" id="A0A1Y1NC00"/>
    <dbReference type="OrthoDB" id="6711293at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08662">
        <property type="entry name" value="M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF224">
        <property type="entry name" value="NEPRILYSIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00786">
        <property type="entry name" value="NEPRILYSIN"/>
    </dbReference>
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    </dbReference>
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        <location>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
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        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="JAV95474.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAB0800207.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
    <sequence length="714" mass="83275" checksum="C68D53DE09A09627" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1NEU2</accession>
    <name>A0A1Y1NEU2_PHOPY</name>
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        <name evidence="10" type="ORF">PPYR_12414</name>
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        <name type="scientific">Photinus pyralis</name>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Coleoptera</taxon>
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            <taxon>Elateroidea</taxon>
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        </lineage>
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    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
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                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
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        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="10">1611_PpyrPB1</strain>
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        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <source>
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</entry>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
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            <dbReference type="DOI" id="10.1038/srep38556"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
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            <authorList>
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                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
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            <dbReference type="PubMed" id="30324905"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
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    <reference evidence="7" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
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        </source>
    </reference>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF74">
        <property type="entry name" value="POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
        <property type="entry name" value="HTH_psq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="5">
        <location>
            <begin position="64"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="428"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="503"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="522"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="539"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="553"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="JAV97001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0799328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="663" mass="75234" checksum="28DA2DBC65DB24E4" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1NGY9</accession>
    <name>A0A1Y1NGY9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cytochrome b5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PPYR_03883</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">1611_PpyrPB1</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">1611_PpyrPB1</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Microsome membrane</location>
            <topology evidence="11">Single-pass membrane protein</topology>
            <orientation evidence="11">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12 14">Belongs to the cytochrome b5 family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01007769">
        <property type="protein sequence ID" value="JAV94947.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0801697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1NGY9"/>
    <dbReference type="FunCoup" id="A0A1Y1NGY9">
        <property type="interactions" value="1667"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1NGY9"/>
    <dbReference type="OrthoDB" id="260519at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000002">
        <property type="entry name" value="Cytochrome b5 type B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050668">
        <property type="entry name" value="Cytochrome_b5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359">
        <property type="entry name" value="CYTOCHROME B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359:SF150">
        <property type="entry name" value="CYTOCHROME B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 14" id="KW-0349">Heme</keyword>
    <keyword evidence="9 14" id="KW-0408">Iron</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0492">Microsome</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="16">
        <location>
            <begin position="2"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="90"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00039806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="JAV94947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAB0801697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="130" mass="14923" checksum="383089FFE80D1B7B" modified="2017-08-30" version="1">MAKLYRREEVKQHNDNENSWIVINNSIYDVTAFLNEHPGGEEVLLEQAGRDGSEAFDDVGHSSDAKELMLKYKIGEVVESERRPVKDKTNTWSTSDDSPPQSFSSLKSWILPITIGILVTIIYRYYFQSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N3ZYG6</accession>
    <name>A0A5N3ZYG6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PPYR_15579</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01001918">
        <property type="protein sequence ID" value="KAB0790102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N3ZYG6"/>
    <dbReference type="InParanoid" id="A0A5N3ZYG6"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF158">
        <property type="entry name" value="GH23626P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024442058" description="Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein" evidence="5">
        <location>
            <begin position="17"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="7">
        <location>
            <begin position="314"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="522"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="566"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0790102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="586" mass="65407" checksum="CAE055F9A6CA0D1D" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N3ZZ52</accession>
    <name>A0A5N3ZZ52_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_15286</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01001438">
        <property type="protein sequence ID" value="KAB0790347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N3ZZ52"/>
    <dbReference type="InParanoid" id="A0A5N3ZZ52"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF269">
        <property type="entry name" value="NUCLEASE HARBI1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="8">
        <location>
            <begin position="107"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0790347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="354" mass="40494" checksum="64BF1562117B7336" modified="2020-02-26" version="1">MYPAQFDKLLELVKPKLLKRSRRPALPPEMRLAMTLKYLAHGGSFVNLCFEFRVGHSTASKTIRETCEAIWEVLHTEYFKRSTDQDWLNISEEFWTRWNFPNTLGAIDGKHVAVQCPTNSGSLYYNYKKYYSIVLLACCDADYKFTWVDIGAYGSENDAGIFKRSQIKIDMETVSSSLPEGELNGSSAKVPYYFVGDEAFPLNHYLLRPYPGSGLTNERLIFNYRLSRARRTIENSFGILASRWRVYRQPLLCSVETSEAIIKATVCLHNFLKINISDKYAPPTLTDVVLNNGEVVEGKWREIVSNDKNLTRVGRIGANVSSKKAYSQRDIVAKYLLTPEGSVPWQMKYINRGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A164</accession>
    <name>A0A5N4A164_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetylglucosaminylphosphatidylinositol deacetylase</fullName>
            <ecNumber evidence="2">3.5.1.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_02839</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PIGL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.89" evidence="2"/>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A164"/>
    <dbReference type="FunCoup" id="A0A5N4A164">
        <property type="interactions" value="1477"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A164"/>
    <dbReference type="OrthoDB" id="440160at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000225">
        <property type="term" value="F:N-acetylglucosaminylphosphatidylinositol deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="entry name" value="LmbE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003737">
        <property type="entry name" value="GlcNAc_PI_deacetylase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993:SF11">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL DE-N-ACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL DE-N-ACETYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02585">
        <property type="entry name" value="PIG-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="LmbE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0791039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="300" mass="35197" checksum="68DC9C65ECA00A8E" modified="2020-02-26" version="1">MQNELAVHLSDSWSAILSTTTTLCSDQFENLSDYTRNASKQFLLAFLIYCTLCVSIYIATFKWKWPLFASDFDEPKRILIVTAHPDDECMFFGPTILNVVRNRKSLVYLMCLSTGANYGMGRTRKRELYDACDILGIEHGHIIIRNHSNLPDAQGARWPTELLSRMILDQIERYDIDTLVTFDKYGISRHINHCSIYYAIAYLSIEKNLPKDCKVYVLETINVLRKYSLIFEIPFSYLLSRRRFILSYADRNVLVSAMRKHKSQMVWFRYLYLTFSRYFIINTLQEMDLEDIELELAVDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A175</accession>
    <name>A0A5N4A175_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chitin-binding type-4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_02841</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A175"/>
    <dbReference type="InParanoid" id="A0A5N4A175"/>
    <dbReference type="OrthoDB" id="64893at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004302">
        <property type="entry name" value="Cellulose/chitin-bd_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21113">
        <property type="entry name" value="AGAP001705-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21113:SF4">
        <property type="entry name" value="CHITIN-BINDING TYPE-4 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03067">
        <property type="entry name" value="LPMO_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024357402" description="Chitin-binding type-4 domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-4" evidence="4">
        <location>
            <begin position="20"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0791041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="322" mass="36149" checksum="9EA9C939B54C6253" modified="2020-02-26" version="1">MIQTSLVLVLIAHLGNVNGHGRLIEPPSRASAWRYGFDTPHNYNDHELFCGGFTRQWQANGGKCGVCGDAWDSKLPRAHEYGGTYGQGVIVRQYNVGSAINLRVELTASHMGYFTFSVCPDYKNASQECLDKHILKTLRPQDGLAMSDIRFYPRDGSRVYEMKYRLPKLSCSHCLLQWRYIAGNNWGACPNGTEQVGCGPQEEFRACADITIGKGFVEQPETTTIEPEVVVTSTALPPSSDESYSPLSAILISIVSFLVVFLIFFLLYFHYYRVGGKIKSWIKQRGENKTEESGAPMPPPRNRRSKSRSDSQSDLQEINLKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A1H3</accession>
    <name>A0A5N4A1H3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nuclease HARBI1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_02918</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A1H3"/>
    <dbReference type="InParanoid" id="A0A5N4A1H3"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0791118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="276" mass="31896" checksum="78F71711F1389EC6" modified="2020-02-26" version="1">MWGYRVIVQKILQSSTLKELHSSHFGVNKCKSLARSYIRDSLALPEPETEHSSSSNLTDINQTPCVAESSVTEEHKHKSILIYEMDPNLAIFAITVLNGMAAAKLKAKRKKSRNCWVKQWVDKRDERGIMQMVNNELRVEDPEKFKNYIRMSKESFFKLLQRVEPHIAKINTNMRQSISARDKLMTTLRFLATGESYRNLMYSTRIHESTISLFIPEVCKCIYSVLKDEYLRLPRTQQPLGQQSGNHFSVRATSIRGEFLNYFNGPGAVEWQEAML</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A2H3</accession>
    <name>A0A5N4A2H3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Calcium release-activated calcium channel protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PPYR_03330</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Orai family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A2H3"/>
    <dbReference type="InParanoid" id="A0A5N4A2H3"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015279">
        <property type="term" value="F:store-operated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002115">
        <property type="term" value="P:store-operated calcium entry"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.140">
        <property type="entry name" value="Calcium release-activated calcium channel protein Orai"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012446">
        <property type="entry name" value="CRAC_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038350">
        <property type="entry name" value="Orai_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31501">
        <property type="entry name" value="CALCIUM RELEASE-ACTIVATED CALCIUM CHANNEL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31501:SF7">
        <property type="entry name" value="CALCIUM RELEASE-ACTIVATED CALCIUM CHANNEL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07856">
        <property type="entry name" value="Orai-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="227"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="13"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0791530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="314" mass="34836" checksum="62B0C0DEAEDD528D" modified="2020-02-26" version="1">MVQGYLGLSKAVTARSSQMDQSPQASLGPKRGRNVLQRYNTTSGATPPIVPQIRITPRPRSLNLHNEIAPPNFATGGGELTLSVISRDRSSPHFLQVPPLPYQPSERSQSIASCCRCELEETPKNLLSWRRLHMSRAKLKATSTTSELLSGFAMVAMVELQINEGTAVPEWLFVMFSVCTTVLVAVHIFALMISTYILPNIDAISKLEVSELVSESPHERMKGFIQLAWAFSTVLGLFLFLVEVAILCWVKFWDYSFTAAIAATVIVIPVLVIFVLFVVHFYHSLVAHRCDTSVEDLEGLENMKKHLDHASSPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A2Z4</accession>
    <name>A0A5N4A2Z4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">sphingolipid 4-desaturase</fullName>
            <ecNumber evidence="3">1.14.19.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PPYR_03500</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the fatty acid desaturase type 1 family. DEGS subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.17" evidence="3"/>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A2Z4"/>
    <dbReference type="FunCoup" id="A0A5N4A2Z4">
        <property type="interactions" value="909"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A2Z4"/>
    <dbReference type="OrthoDB" id="200948at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042284">
        <property type="term" value="F:sphingolipid delta-4 desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03508">
        <property type="entry name" value="Delta4-sphingolipid-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011388">
        <property type="entry name" value="DES1/DES2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013866">
        <property type="entry name" value="Sphingolipid_d4-desaturase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12879">
        <property type="entry name" value="SPHINGOLIPID DELTA 4 DESATURASE/C-4 HYDROXYLASE PROTEIN DES2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12879:SF8">
        <property type="entry name" value="SPHINGOLIPID DELTA(4)-DESATURASE DES1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08557">
        <property type="entry name" value="Lipid_DES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017228">
        <property type="entry name" value="Sphnglp_dlt4_des"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01269">
        <property type="entry name" value="Lipid_DES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="107"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Sphingolipid delta4-desaturase N-terminal" evidence="11">
        <location>
            <begin position="5"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR017228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAB0791700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="321" mass="37261" checksum="BD770050506FDD6A" modified="2020-02-26" version="1">MGQRVSRTDFEWTYTEEPHASRRKVILEKYPQIKKLFGYDPNFKWVVSFMVAIQFAMLFVMRDRSWGVTLLAAYCFGGVINHSLMLAIHEIAHNLAFGHARPFANRLFGFFANLPIGLPVSISFKKYHLEHHRYQGDELIDTDIPTYIEAKLFCTTVGKIFWVMLQPFFYTIRPLMVNPKPPTLLEFVNLVIQLVFDVIVAYFFGVRVLLYLVLGSLMAMGLHPVAGHFISEHYMFKKGFETYSYYGPLNWITFNVGYHNEHHDFPAVPGSRLPLVKKIAPEFYDDLPQHNSWSAVLYDFIMDPDIGPYARIRRRTVGLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A3G0</accession>
    <name>A0A5N4A3G0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Haemolymph juvenile hormone binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_03641</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A3G0"/>
    <dbReference type="InParanoid" id="A0A5N4A3G0"/>
    <dbReference type="OrthoDB" id="8196554at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.30">
        <property type="entry name" value="Haemolymph juvenile hormone binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010562">
        <property type="entry name" value="Haemolymph_juvenile_hormone-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038606">
        <property type="entry name" value="To_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008:SF32">
        <property type="entry name" value="CIRCADIAN CLOCK-CONTROLLED PROTEIN DAYWAKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008">
        <property type="entry name" value="PROTEIN TAKEOUT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06585">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00700">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024443455" description="Haemolymph juvenile hormone binding protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0791841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="241" mass="26796" checksum="49318653ADD56D14" modified="2020-02-26" version="1">MNMCVLIVLLGTALFATIEPAQLPSYIPRCYQNDRNINECFISAANSLNENVRSGIPELGLRPLDPFVAPDLNITLESPITDLFVATQRFTFHRFYNYRFTSADIRPKDGAVSGSVTFPDLGASVDYILQGHLINLPIGGAGVAKFKFAAINCDFLIDNWLEKATCGEIKLELTCKIEDVEMNFTGLSNEEMMNRLLNLSSKLVASEVSPAYSNIFKALLRPFLKRLCKKYPLGELFPPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A483</accession>
    <name>A0A5N4A483_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_14040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A483"/>
    <dbReference type="InParanoid" id="A0A5N4A483"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0792079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="120" mass="13869" checksum="3DE00D96491024CE" modified="2020-02-26" version="1">MLERSLMVRAQTKTLLHTKFFLVPCSFVKVLSDPCQSVQEQRVGIIDEDEETGGQNLLTRRYPKSSESTSKRHLLPLVWKVPASQAKEGERRPPRWTLHHIEGGEAPHFTSRYTTRQQQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A4P0</accession>
    <name>A0A5N4A4P0_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_14231</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A4P0"/>
    <dbReference type="InParanoid" id="A0A5N4A4P0"/>
    <dbReference type="OrthoDB" id="2386367at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058519">
        <property type="entry name" value="DUF8206"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32046">
        <property type="entry name" value="G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32046:SF11">
        <property type="entry name" value="IMMUNE-ASSOCIATED NUCLEOTIDE-BINDING PROTEIN 10-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26633">
        <property type="entry name" value="DUF8206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="2">
        <location>
            <begin position="38"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8206" evidence="3">
        <location>
            <begin position="364"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="623"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="708"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="623"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="651"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="747"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="791"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="809"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="844"/>
            <end position="856"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0792272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="904" mass="104528" checksum="198EF9C0483243CD" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A5L3</accession>
    <name>A0A5N4A5L3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AIP/AIPL N-terminal FKBP-type PPIase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PPYR_14585</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A5L3"/>
    <dbReference type="FunCoup" id="A0A5N4A5L3">
        <property type="interactions" value="404"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A5L3"/>
    <dbReference type="OrthoDB" id="5829758at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000052">
        <property type="entry name" value="Aryl-hydrocarbon-interacting protein-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039663">
        <property type="entry name" value="AIP/AIPL1/TTC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056277">
        <property type="entry name" value="PPIase_AIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11242">
        <property type="entry name" value="ARYL HYDROCARBON RECEPTOR INTERACTING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11242:SF0">
        <property type="entry name" value="TPR_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23322">
        <property type="entry name" value="PPIase_AIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="AIP/AIPL N-terminal FKBP-type PPIase" evidence="5">
        <location>
            <begin position="18"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0792626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="325" mass="37136" checksum="4DD4AB9091FB3EE5" modified="2020-02-26" version="1">MSTSISGDPKIIKKVLHAGSKAVNFGNDCKVQFHFQTRLCDQDKTLLDDSRRMGDGKPLEIILGRKFKFELWEAIVQCMAIGEVSQFTVSKDLLTQYPFVSKTLRDVHLPADKRNNHRCVMTAHQHGIGHDDLNRLMSNPADLEFTIELVKVEEPNEYQKESWQMNELEQVDRVHELKELGNAEYKSSNHEAASKMYAEAIGILERLMIKEKPQSEEWNDLNKMKIPLLSNYSQCMMAKGDFYAVIEHCTSVLKIEPDNVKALFRRAKAHIGAWNPTEARADFERVVKLDHGLAASVKKEIDVLDQLIKSKDGTDKQLFKGMFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A5T1</accession>
    <name>A0A5N4A5T1_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_14642</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A5T1"/>
    <dbReference type="InParanoid" id="A0A5N4A5T1"/>
    <dbReference type="OrthoDB" id="7665616at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23992">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.20">
        <property type="entry name" value="Pheromone/general odorant binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006170">
        <property type="entry name" value="PBP/GOBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036728">
        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01395">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024282199" evidence="1">
        <location>
            <begin position="20"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0792683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="144" mass="16044" checksum="4421E8E2AA5BACDB" modified="2020-02-26" version="1">MNLLRVFVYLPLAFLASQAATPEEIANAWRKQIAPFETVCACESGSSVENIQSTWASFTYPTNPCFKCYFPCLYRKLGLVLPDGSINRDVMIKTVLGVTGTIYDTCMAPVVKCLDPCYKIWAFDYCVSYVMNYTAVKPAITACT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A668</accession>
    <name>A0A5N4A668_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Golgi integral membrane protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_14718</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A668"/>
    <dbReference type="InParanoid" id="A0A5N4A668"/>
    <dbReference type="OrthoDB" id="6288648at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042336">
        <property type="entry name" value="GOLIM4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22909">
        <property type="entry name" value="GOLGI INTEGRAL MEMBRANE PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22909:SF24">
        <property type="entry name" value="GOLGI INTEGRAL MEMBRANE PROTEIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="426"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="451"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="463"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0792759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="476" mass="53925" checksum="9526C2105AB86C84" modified="2020-02-26" version="1">MSSSRVVRGSKGRILLGIFVIVALTIIIACFNNILNQLSETRKNYEQCHQQQENLSTQLQVIFDYKQRLEKSLKTEKAEHQQTKKELDARLEEEQTNHEKSVSEINLKFSSLQQHYNILQAEYNDFKEESSKIQRQQLNEVNDLQSKLKELEGQFKQSIKEKDKNFEHLKTQYAQIQVDKENLESQMKGTLDGHIQSESDINHLKKVNFELTKEIEELKKKLPTQNEAQADDTNIKPPEVKQTDNEPKDPNDNGDNVLPAPNNDLHPNQKSSTPSSSSLVSKASFDAVAPIHVPIVTSSKTPNKQAEPPALPLPYKRVLPAGVPPVPAAAVDDSKPKPEEEKDVRDEINNGYPNRYRSNIIVNEMAKEEAEKQSALKVEAGDRENKALEVFDPPLNNLDAFGIEDPHEVKRVQQNNAPGIQVEGVKAQGHNKAYDAQNNGDYDKEVMNDMQLEEEAEDDDPDYGDHMARKDPAVRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A6Q0</accession>
    <name>A0A5N4A6Q0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">guanylate cyclase</fullName>
            <ecNumber evidence="2">4.6.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PPYR_12615</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.2" evidence="2"/>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0792995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A6Q0"/>
    <dbReference type="FunCoup" id="A0A5N4A6Q0">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A6Q0"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001653">
        <property type="term" value="F:peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007168">
        <property type="term" value="P:receptor guanylyl cyclase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000028">
        <property type="entry name" value="Guanylate cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018297">
        <property type="entry name" value="A/G_cyclase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011645">
        <property type="entry name" value="HNOB_dom_associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013587">
        <property type="entry name" value="Nitrate/nitrite_sensing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF504">
        <property type="entry name" value="GUANYLATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07701">
        <property type="entry name" value="HNOBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08376">
        <property type="entry name" value="NIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00452">
        <property type="entry name" value="GUANYLATE_CYCLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0141">cGMP biosynthesis</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="13">
        <location>
            <begin position="359"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAB0792995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="572" mass="64137" checksum="07786DB1AEE3B106" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A7H0</accession>
    <name>A0A5N4A7H0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_12865</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWC22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A7H0"/>
    <dbReference type="FunCoup" id="A0A5N4A7H0">
        <property type="interactions" value="1147"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A7H0"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000032">
        <property type="entry name" value="Nucleolar MIF4G domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050781">
        <property type="entry name" value="CWC22_splicing_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003891">
        <property type="entry name" value="Initiation_fac_eIF4g_MI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN CWF22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034:SF4">
        <property type="entry name" value="NUCLEOLAR MIF4G DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02847">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00544">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51366">
        <property type="entry name" value="MI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MI" evidence="6">
        <location>
            <begin position="620"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="201"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="93"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="212"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0793245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="829" mass="96075" checksum="751280AD744078B7" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-09-13" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A7I3</accession>
    <name>A0A5N4A7I3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_12838</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A7I3"/>
    <dbReference type="InParanoid" id="A0A5N4A7I3"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0793218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="99" mass="11557" checksum="A9487F0DEF297F1C" modified="2020-02-26" version="1">MCQIRTSNIRRFKATFDGVTYRIDLTDICSICNSNSIQSFQHVFFECVPLRQGLTLDTEIVSNCENLLYFLNDISKDNVKAVVHYFLNILRLRSFILNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-06-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A7Q1</accession>
    <name>A0A5N4A7Q1_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_12898</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A7Q1"/>
    <dbReference type="InParanoid" id="A0A5N4A7Q1"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0793278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="127" mass="15216" checksum="20D37ABA51B674F1" modified="2020-02-26" version="1">MTQFCRFWLVVEDICQWCHLRFQAKGIFSYSLYPELGRNFLLIQDRKRKLQYFLVAFHQLNAYVRYFPNSAVSVNFTLRRRLDYDGKINKILLQSEATTLIFHESLALPDFARIYIGRSVLKDNLRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A821</accession>
    <name>A0A5N4A821_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Odorant receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PPYR_13084</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cell membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A821"/>
    <dbReference type="FunCoup" id="A0A5N4A821">
        <property type="interactions" value="13"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A821"/>
    <dbReference type="OrthoDB" id="6756505at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU351113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0793464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="426" mass="48900" checksum="2CAA229C3F0DE986" modified="2020-02-26" version="1">MIFLITMYKYLHPHPLNVIIRMSTKSDVYFRRELLMLRLIGISFADNEKVSYRIYAFFCNVLLFGYPVIAFSDLFKHEFDIVADLLIYELATIMVCCEAFVVMWNRQKLKALFRKLECAPFTPNFERGGEVEESFLKDFSIVTGRQANICWGSVFSTVGMSIVATIIKRVRSSDYRDWEFTYGPLTVLDVTRSPYFEITWLYQITCVLVIGLTHCSVILIISEILGHASVQFKILQNNLSQVTENAHRIMTKKVRGVAGDEVDVSKVPWKYLQKSLNEAISYHLSILDVTSEVEKTINMLTLIIFLFSLAVTCFQVYHASILSAFNVRFLKCFTDSSSAIFPVFILCFWSHQVAHESEQVAKYAFQANFVGSDLRYQKGLNLIMVRGQRPVILKAGKFIEISLPTFVSIIRASYSAFMVLRSVNEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A837</accession>
    <name>A0A5N4A837_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA methyltransferase 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PPYR_13116</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A837"/>
    <dbReference type="FunCoup" id="A0A5N4A837">
        <property type="interactions" value="931"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A837"/>
    <dbReference type="OrthoDB" id="414133at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.120.10">
        <property type="entry name" value="DNA Methylase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050750">
        <property type="entry name" value="C5-MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001525">
        <property type="entry name" value="C5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00675">
        <property type="entry name" value="dcm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46098">
        <property type="entry name" value="TRNA (CYTOSINE(38)-C(5))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46098:SF1">
        <property type="entry name" value="TRNA (CYTOSINE(38)-C(5))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00145">
        <property type="entry name" value="DNA_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00105">
        <property type="entry name" value="C5METTRFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51679">
        <property type="entry name" value="SAM_MT_C5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="active site" evidence="4">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0793496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="332" mass="38106" checksum="EB678223219C0A39" modified="2020-02-26" version="1">MKILELYSGIGGMHFSFKESGLEGEVIASVDINQTANLVYGHNFKDTLLLNRNIQSLTFEYINSLEVDTILMSPPCQPFTRNGLQRDVNDARTISFMHIINILQELNIRNILMENVKGFESSDMRDLFIGKLKECNFQYQEFLLSPTQFGIPNTRCRYYCLAKKQPAKLCFECGPLMTHHPTKTAETPYVLSEIVDNGNVERYLLSDTDLLKRAIALDICFKTCTRSCCFTKSYGRYVTGTGSVYTDKTKQELDYVYRSLDSLKGDREGYLSCIRQLRLRFFTPKEVCRLMSFPDTFEFPSTVTDKQKYMLLGNSINVRVVSELIKLLNDPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-06-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A9G1</accession>
    <name>A0A5N4A9G1_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_13586</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A9G1"/>
    <dbReference type="InParanoid" id="A0A5N4A9G1"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0793966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="107" mass="12196" checksum="CD583D2EC974A715" modified="2020-02-26" version="1">MSVISDIQALSDIFTSKMQGFELQLQSAMVKQSNSEGPIINEIADNFIAFKKFVISALEKMREKVCIFESKIDYLENCSRKNCLLIHGIPETKGERIENVLFVNHLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AAI1</accession>
    <name>A0A5N4AAI1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Osiris 20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_11153</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0794314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AAI1"/>
    <dbReference type="FunCoup" id="A0A5N4AAI1">
        <property type="interactions" value="58"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AAI1"/>
    <dbReference type="OrthoDB" id="6631139at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012464">
        <property type="entry name" value="DUF1676"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21879">
        <property type="entry name" value="FI03362P-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21879:SF2">
        <property type="entry name" value="OSIRIS 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07898">
        <property type="entry name" value="DUF1676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0794314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="243" mass="26182" checksum="CC61306BA0387A46" modified="2020-02-26" version="1">MAAAVASASALIGGEIRTGNQLLSSVVSNCADMGCVKEHVISYLDTMIDKDYTSGRQFKNMDAAILKRVSRIIKTHEFRLTLPEFMFDKTQVVYNPKSGLDVVSTDGEEGRGLLKKKLLLPVLLLLKLKMKALLPIFVALIGLKSFKALILSKLAITIVLGFIIYTLLTKSGMPMPMSMAPVEPPAPIYGPPASTAAPNSYEPSWEPNSGGPYSRVWNSANDAHNLAYSAYYPGPVSSSTAGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AB72</accession>
    <name>A0A5N4AB72_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4218 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_11406</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0794567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AB72"/>
    <dbReference type="InParanoid" id="A0A5N4AB72"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33053">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0794567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="359" mass="41892" checksum="0F11F71E115F578B" modified="2020-02-26" version="1">MNGVQVNVKLNAIICDAPAKAFVCGIKGHSGYFGCGKCTQEGDFIQNRVVFPEVNNPLRMDTTFKRKTQPEHHIRESCLEKLGLEWFHRLPRTLLEVDNWKATEFRQFLLYSGPILLLNRLPNIYYEHFVSLSVALRILIDSELCFKLNKYAESLLVWFVKFYGDLYGEEFLSYNVHNLIHLAADVKELGSLDKFSAFKFENFMQEIKHKLQNSGNYLQQFVNRLREEMCLSVTYENSKKYPIIFYCKNNVQIVDYIQFDGFTISKSKYDNCILLHNGMYGIVNDITVIDNNCELCINRFSKSEPFFSLPCDSRKHGIAIIDLKEIQKVTISVKSIKRKCIMFDYSKYKYVFLPLLHSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ABV1</accession>
    <name>A0A5N4ABV1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_11630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0794791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ABV1"/>
    <dbReference type="InParanoid" id="A0A5N4ABV1"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042477">
        <property type="entry name" value="HMGXB4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46584">
        <property type="entry name" value="HMG DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46584:SF1">
        <property type="entry name" value="HMG DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0794791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="324" mass="35547" checksum="5DFBC159A6EB3B45" modified="2020-02-26" version="1">MDNFQLKKQKAEDLEVTGVSRSGRVRKKSSKLMDFESPDEIDRNYKRQNAAPRKHSDQFDLLSPRSNRDVKPFPSPQKSEEEYPYDDMDPHGSGSEFDSETYDDGNQPESSEDSMGSETDYEDSPEPAGFRRLDPDADNLGNQSLYMAEKSAKKRLVIKDGKIVGRAKAQRKDKEQQDPKFKSTGKSGNKFINKKGGGAGAVQSPSSTFQLELPSLGNINNSPPSPRGRESNLIFKSTGIKPIDVAAHLKLLGESLTIIGERLKEHEGQIAVSGSLSVLLDSLLCALGPLLCLTQQVPELQGSSCTTEQLATILDNVAFIMPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-06-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AD19</accession>
    <name>A0A5N4AD19_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_12018</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0795179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AD19"/>
    <dbReference type="InParanoid" id="A0A5N4AD19"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="7"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="386"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="572"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="679"/>
            <end position="794"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0795179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="984" mass="113919" checksum="A359081E5542917F" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AEH3</accession>
    <name>A0A5N4AEH3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">BRCA2 OB1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PPYR_09783</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0795722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AEH3"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04493">
        <property type="entry name" value="BRCA2DBD_OB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015525">
        <property type="entry name" value="BRCA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015252">
        <property type="entry name" value="BRCA2_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036315">
        <property type="entry name" value="BRCA2_hlx_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015187">
        <property type="entry name" value="BRCA2_OB_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015188">
        <property type="entry name" value="BRCA2_OB_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002093">
        <property type="entry name" value="BRCA2_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11289:SF0">
        <property type="entry name" value="BREAST CANCER TYPE 2 SUSCEPTIBILITY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11289">
        <property type="entry name" value="BREAST CANCER TYPE 2 SUSCEPTIBILITY PROTEIN BRCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09169">
        <property type="entry name" value="BRCA-2_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09103">
        <property type="entry name" value="BRCA-2_OB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09104">
        <property type="entry name" value="BRCA-2_OB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00634">
        <property type="entry name" value="BRCA2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81872">
        <property type="entry name" value="BRCA2 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81878">
        <property type="entry name" value="BRCA2 tower domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50138">
        <property type="entry name" value="BRCA2_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Breast cancer type 2 susceptibility protein helical" evidence="9">
        <location>
            <begin position="735"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="domain" description="BRCA2 OB1" evidence="7">
        <location>
            <begin position="848"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="domain" description="BRCA2 OB3" evidence="8">
        <location>
            <begin position="1195"/>
            <end position="1325"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="661"/>
            <end position="688"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0795722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1389" mass="155103" checksum="9370426FA8539D03" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AFR0</accession>
    <name>A0A5N4AFR0_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_10129</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AFR0"/>
    <dbReference type="InParanoid" id="A0A5N4AFR0"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024389798" evidence="2">
        <location>
            <begin position="23"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="178"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0796068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="192" mass="21419" checksum="2305681BB43320B8" modified="2020-02-26" version="1">MSPLSVLLCALVALSPLGSSNGWDFPKGHYGSWRERLASDKEKKGDDWRPQHFTPRSDLLHHEASLHDWVEKHLKPLAAKHGPFFRRPQHHENEAPPHGMVRPSVGDEPIPESVKKDVLDRLKEIEKMLIAELSTGHQTPAVAEVVVNTEKNDHSPPPPTEKPATKKPTEKPKDVTTEKATTPPKSKTTTDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AG87</accession>
    <name>A0A5N4AG87_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_10385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AG87"/>
    <dbReference type="InParanoid" id="A0A5N4AG87"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0796324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="365" mass="41595" checksum="4663B393B5630ACD" modified="2020-02-26" version="1">MESDIDTSRDTSIWQNIEKTTNIIFPPYLKNLMTAFGFDNEISISAFAEDDIPKLENFALTVLPLILPENCSSEEKKKYFGIFYANIKNFQIVDGHKKLLIKLINYYTSKNSEKNSVQKPKSKRQKQTISKILDTPDARPDDIPEGGADNSKSQTPLSLPSSNETINEKEEKTKIRQMCLKWLVSYKENLPPNKDSIKEIISSHLDSKIDYNIRVYTTPQSAVNCAIAYLTCSFCKADIKIVNAIKENKTYWTLSNFFKHIRNHYDSKSKKQRFNTLHQYFNKYNESESATSEATSFKPGTSAEVEAEARAEVYNYQRSKQKENVQADTLPADANGDGESDDVTIILQEVVEQVEGVGEPQQDFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AH05</accession>
    <name>A0A5N4AH05_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Magnesium-dependent phosphatase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_10658</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AH05"/>
    <dbReference type="InParanoid" id="A0A5N4AH05"/>
    <dbReference type="OrthoDB" id="2865258at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07501">
        <property type="entry name" value="HAD_MDP-1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010033">
        <property type="entry name" value="HAD_SF_ppase_IIIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035679">
        <property type="entry name" value="MDP-1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010036">
        <property type="entry name" value="MDP_1_eu_arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01681">
        <property type="entry name" value="HAD-SF-IIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01685">
        <property type="entry name" value="MDP-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17901:SF14">
        <property type="entry name" value="MAGNESIUM-DEPENDENT PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17901">
        <property type="entry name" value="MAGNESIUM-DEPENDENT PHOSPHATASE 1 MDP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12689">
        <property type="entry name" value="Acid_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01131">
        <property type="entry name" value="C1.5.2:_MDP_Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0796597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="170" mass="19370" checksum="63DA7D9BFCCDC571" modified="2020-02-26" version="1">MAASTSSTETRPKLIVFDLDYTLWPFWVDTHVTPPFRKSSSGKIVDARGATISCYKEVPKVLKKLNEDGYTLGVASRTSEIQGANQLIKLFGWSKYFKYKEIYPGSKTAHFARFKKQLEVPYSDMLFFDDESRNIRDLKEVGVTSILVKDGVDAKVVEMGIREYRNEHSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AHP2</accession>
    <name>A0A5N4AHP2_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aromatic amino acid beta-eliminating lyase/threonine aldolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_10799</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the threonine aldolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AHP2"/>
    <dbReference type="FunCoup" id="A0A5N4AHP2">
        <property type="interactions" value="112"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AHP2"/>
    <dbReference type="OrthoDB" id="10261951at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008732">
        <property type="term" value="F:L-allo-threonine aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006545">
        <property type="term" value="P:glycine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:L-threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06502">
        <property type="entry name" value="TA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000030">
        <property type="entry name" value="Low-specificity L-threonine aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001597">
        <property type="entry name" value="ArAA_b-elim_lyase/Thr_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023603">
        <property type="entry name" value="Low_specificity_L-TA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041359">
        <property type="entry name" value="GntG_guanitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48097:SF9">
        <property type="entry name" value="L-THREONINE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48097">
        <property type="entry name" value="L-THREONINE ALDOLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01212">
        <property type="entry name" value="Beta_elim_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017617">
        <property type="entry name" value="Thr_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aromatic amino acid beta-eliminating lyase/threonine aldolase" evidence="6">
        <location>
            <begin position="22"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5">
        <location>
            <position position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR017617-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0796738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="408" mass="45177" checksum="EFD71D228E5F8B88" modified="2020-02-26" version="1">MPPVVEVVTGSNSEVYSVHVVDMRSDTVSKPTPAMRQAMAVAEVGDDVMGEDPTVRELERRAAEMLGKESAIFVPSGTMANLIAIMVHCEQRGSEFIAGHKSHIFLYEQGGSASLAGAQCSLVKNNPDGTFDLGELRKRIRVKVDFHEPITSLILVENTHNMCGGQVIPLSWLDELHSITSQHKIPIHMDGARLVNAVIQSKVPASRIVRDMASVSLCLSKSLGCPIGSMLCGSEKFITHARRIRKLLGGGLRQSGIVAAAGLVAFDEMIDRLQIDHDNTYKIAKGIHCLQSELIRVDLDRVQTNILMVHVADERMSADDFSKRMATIKETDTVKVIVKVSVRHAKCVRIVLHWEIDDHDVEKTVEKIYMVVKEFEMNSFRKMQGLCIGSTEDSQKKSFDSVHPRLKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AI17</accession>
    <name>A0A5N4AI17_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Band 7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PPYR_02797</name>
        <name evidence="7" type="ORF">PPYR_11028</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the band 7/mec-2 family. Flotillin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0790997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AI17"/>
    <dbReference type="InParanoid" id="A0A5N4AI17"/>
    <dbReference type="OrthoDB" id="6080404at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016600">
        <property type="term" value="C:flotillin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002020">
        <property type="term" value="F:protease binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901890">
        <property type="term" value="P:positive regulation of cell junction assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000049">
        <property type="term" value="P:positive regulation of cell-cell adhesion mediated by cadherin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045807">
        <property type="term" value="P:positive regulation of endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070528">
        <property type="term" value="P:protein kinase C signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002090">
        <property type="term" value="P:regulation of receptor internalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03399">
        <property type="entry name" value="SPFH_flotillin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031905">
        <property type="entry name" value="Flotillin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027705">
        <property type="entry name" value="Flotillin_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13806:SF46">
        <property type="entry name" value="FLOTILLIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13806">
        <property type="entry name" value="FLOTILLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15975">
        <property type="entry name" value="Flot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="5">
        <location>
            <begin position="87"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0790997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0796967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="429" mass="47565" checksum="9F9B448C26DD7677" modified="2020-02-26" version="1">MGWGFYTCGPNEALVVSGCCYRRPHVVPGGRVWVWPCVQLVQKISLNTMTLQIDSPKVYTSQGVPISVSGVAQVKIQGQNKDMLLAACEQFLGKKESEVQHIALATLEGYQRAIMGSMTVEEIYKDRKKFSRQVFEVASSDLVNMGITVVSYTLKDISDDTGYLLSLGMARTAEVKRDARIGEAEARAEATIKEALAEEQRMASVLHNDTLIAKAKRDYELKKAAYDLEVHTQRATAELAYDLQAAKTKQRIREEEMQIKVVERTQQIAIQEQETSRRLQELESTIRRPAEAEKYRLEKIAEANCKRVVLEAEAEAEALRLKGEAEAFAIEAKAKAEAEQMAKKAEAWKEYKRAAMVDMFMDILPQVVAEVSAPLSQANKITMVSTGQGEIGAAKLTSEVLTMVAGIPQVVKAMTGVDLVQNLQSIRSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AI29</accession>
    <name>A0A5N4AI29_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_11063</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0797002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AI29"/>
    <dbReference type="InParanoid" id="A0A5N4AI29"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23992">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036728">
        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024443883" evidence="1">
        <location>
            <begin position="18"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0797002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="125" mass="14284" checksum="DAE784CE91536CDE" modified="2020-02-26" version="1">MKFSLIVGLSLLTCSAALHMVVPIYLREAWYAMISPYISECVCETRVDPSFVRRTFLETEFPDDSSTGEWNEKELVRQVAGVTPEIASTCNNQTAGLVDVCEKTFNFYQCLVYSVMVEEYYDHKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AIH6</accession>
    <name>A0A5N4AIH6_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_08108</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AIH6"/>
    <dbReference type="InParanoid" id="A0A5N4AIH6"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23992">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.20">
        <property type="entry name" value="Pheromone/general odorant binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006170">
        <property type="entry name" value="PBP/GOBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036728">
        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01395">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024398233" evidence="1">
        <location>
            <begin position="17"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0797114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="135" mass="15783" checksum="B5C5CF585588C91F" modified="2020-02-26" version="1">MKPLITFLVILCTTTAFKFNVNPELTKKWIAMIGPYNDQCATENAIDKNKPYKAILNMNYPENRSFQCYAECIWWRWGFYDSETDTIDGDKIEKVIAGFTKGDTEQCFKTYKMIDDHCQKIFSTIKCCIGKLMRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AIZ3</accession>
    <name>A0A5N4AIZ3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF5641 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_08319</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AIZ3"/>
    <dbReference type="InParanoid" id="A0A5N4AIZ3"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008042">
        <property type="entry name" value="Retrotrans_Pao"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05380">
        <property type="entry name" value="Peptidase_A17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0797325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="204" mass="23121" checksum="7EB93C73B45073CA" modified="2020-02-26" version="1">MLLNEHMPYGCCIYLKPTDKHNFIINLLSAKSRIAPLEKAFTTNTILGLPIERFSSLIKLKRVTAYCLRFITNLRTEKSSRHQGILSVDYNCGPSLLKSGVGRGIQHVKAYPLTPAHFLIGHLFTTLPDPDVRDVAQNRLNRYQVGTKAQQSVLGQMVKGILKIGSLVILKNEHSLPCHWKLGRIIQATSRFRWNYSSGYGEMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AJ67</accession>
    <name>A0A5N4AJ67_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_08386</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AJ67"/>
    <dbReference type="InParanoid" id="A0A5N4AJ67"/>
    <dbReference type="OrthoDB" id="6775814at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024327191" evidence="3">
        <location>
            <begin position="17"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0797392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="186" mass="20003" checksum="9CC0609E0566DF92" modified="2020-02-26" version="1">MLRLVISCICLALAAAQTPGPFPVAGGFPGQFGAHPFFPGYGPQPHAFPVQPNPSPAPVPKPIVAPKPIAPAPQFPKGHIDILSQQNFPYHPHHQPGQFIPILRQNSNQQPGAGYQWDFASANGISAYENAEIIPINEEQATKNVQGGYQYTSPEGIPVEVTYTAGDFGFVPNVRVHIGHAGEYKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AK00</accession>
    <name>A0A5N4AK00_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PPYR_08619</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">1611_PpyrPB1</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AK00"/>
    <dbReference type="InParanoid" id="A0A5N4AK00"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11056">
        <property type="entry name" value="CYP6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000042">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050476">
        <property type="entry name" value="Insect_CytP450_Detox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292:SF45">
        <property type="entry name" value="CYTOCHROME P450 6G1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0492">Microsome</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024301174" description="Cytochrome P450" evidence="15">
        <location>
            <begin position="19"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="431"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAB0797626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="488" mass="55514" checksum="6EE960A459BB96E3" modified="2020-02-26" version="1">MLIVLVLVVLLYAYLTRNKNYWKNLGVPFDKPVPLFGSLLPLAKQAISVGDFFCKLYRSTDHPYYGLFILGQPSLLLRDPRLIQDMLIGDFECFQERMGGKCDHDQIGTNILFYMKASSWKVMRGNLSPFFSSSKLSRMLELINSVGENLVSHIRKKTSVGLAVNSLDASTMYVTDIVASCFFGFISDSLSKGVTEFLQISELWTKLTFMRVVQTSCFVFVPTLAKMFKIKLFDQTSEKYLQDVFLQVMGERKRSGQERRDLVDLLIKIEKEQSHLFKREEIIAQTLQLHFGSYDTTSYSTSFALYELCANVGIQKKLRGEINSVLSQHEIVSLEAIKKMSYLHMVVSESLRKHPIIPIMDRVCSKPYTIPNSSVTIKAGTPCFVSIYGLHYDSRYFPNPETFDPERFSPENKANIIPGTYIPFGVGPRNCIGSRFAVLAVKVALICIIRNFEFELAEDAGSFLGYDRKAFLLTPRNKSLNIKYKPIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AKA4</accession>
    <name>A0A5N4AKA4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_08732</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AKA4"/>
    <dbReference type="InParanoid" id="A0A5N4AKA4"/>
    <dbReference type="OrthoDB" id="6682367at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902936">
        <property type="term" value="F:phosphatidylinositol bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1200">
        <property type="entry name" value="Alpha-tocopherol transfer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.20">
        <property type="entry name" value="N-terminal domain of phosphatidylinositol transfer protein sec14p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174">
        <property type="entry name" value="ALPHA-TOCOPHEROL TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174:SF216">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="111"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0797739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="309" mass="35614" checksum="74CC58D093FD90F4" modified="2020-02-26" version="1">MYREITDELKQSAECKLNEVSSRIEDDIEHIRQWMAKQPHLSFEIDNQLILSFLRCSKFSLQQTKEKIDAHYTARTIMPEMFSNRDPFLPEIQHLLNAGVMLPLPNLDPGDGSRIICATYGRNLDPNLVNLYNVSKLVYMVLDILLMEDDNMIINGIKILVQAKGFPLGFLPNVTPVYMKKHWYGIEKGFPFRIQELCVAHLPAPFVFAYNVLKKFASGKMSQRMVLVSESKIPELCQKSPHYFPKEMGGNNGSVQELIVTWKKKVESYKEWYLQEETKKSYENLRIGKPKTSSGELGVEGSFRQLDID</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AMA7</accession>
    <name>A0A5N4AMA7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_09437</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AMA7"/>
    <dbReference type="InParanoid" id="A0A5N4AMA7"/>
    <dbReference type="OrthoDB" id="5969565at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070888">
        <property type="term" value="F:E-box binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061564">
        <property type="term" value="P:axon development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007423">
        <property type="term" value="P:sensory organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11428">
        <property type="entry name" value="bHLH_TS_NGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050359">
        <property type="entry name" value="bHLH_transcription_factors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19290:SF163">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX NEURAL TRANSCRIPTION FACTOR TAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19290">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX PROTEIN NEUROGENIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="2">
        <location>
            <begin position="155"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0798444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="317" mass="36160" checksum="0A87033358C20C81" modified="2020-02-26" version="1">MSRIGYMNSSYYGYDDSKDSGFDISFKSETSDVVDDMFDNERFSNNDKIYKVEESDSKILYEKFNAAFYKGLGESSFDHFKSYKSESSTEFNCDESLSESEFLNNEFLTSTPVKNRKRASTSSFKESKPKRRYSTGRHRVSRTKSPTHVQRLKKNRRMKANDRERNRMHILNEALDRLRCVLPTFPEDTKLTKIETLRFAYSYIWALSQTVNNVDKYSSSETGVVTVNVGNVTVSISREGNTITSKHCGDQNVSTAVVTSGSINNASFMQGFDFDLKTGSPSPYWLPASNPCSTYPSICPSPYTYDFNSPDMVYECI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AMT1</accession>
    <name>A0A5N4AMT1_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_08255</name>
        <name evidence="3" type="ORF">PPYR_09643</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AMT1"/>
    <dbReference type="InParanoid" id="A0A5N4AMT1"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036728">
        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036147776" evidence="1">
        <location>
            <begin position="21"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0797261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0798650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="130" mass="14231" checksum="2C4A1B41CF1570D9" modified="2020-02-26" version="1">MKLGSLVFVAGLLVVGRVNGQEWLTKWPTITSCICKTGYNANSALQFLKSCTLPVEPCANCFLACQREHMKAMLATGAVNVTFYTSRNSKLTAAQVQECDTPLANEKDKCKRAQLFDACLKAINPTCLSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AQ91</accession>
    <name>A0A5N4AQ91_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DIRP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_07313</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the lin-9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AQ91"/>
    <dbReference type="FunCoup" id="A0A5N4AQ91">
        <property type="interactions" value="495"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AQ91"/>
    <dbReference type="OrthoDB" id="2339771at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017053">
        <property type="term" value="C:transcription repressor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033471">
        <property type="entry name" value="DIRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010561">
        <property type="entry name" value="LIN-9/ALY1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045831">
        <property type="entry name" value="LIN9_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21689">
        <property type="entry name" value="LIN-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21689:SF2">
        <property type="entry name" value="PROTEIN LIN-9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06584">
        <property type="entry name" value="DIRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19438">
        <property type="entry name" value="LIN9_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01135">
        <property type="entry name" value="DIRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DIRP" evidence="6">
        <location>
            <begin position="193"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="101"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="452"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="34"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="67"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="152"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0799433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="604" mass="68388" checksum="3FC4F43C6A52275A" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AQ95</accession>
    <name>A0A5N4AQ95_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_07359</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AQ95"/>
    <dbReference type="InParanoid" id="A0A5N4AQ95"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031720">
        <property type="entry name" value="DUF4728"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47510:SF3">
        <property type="entry name" value="ENDO_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47510">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15860">
        <property type="entry name" value="DUF4728"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0799479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="251" mass="27845" checksum="7B6DF27D229AED65" modified="2020-02-26" version="1">MVVEFPDFCCGISLKTGTIIIGVIQSILSFMFMVLCAAYAENPHELVDMTDKSLLPDTLTLRCLLIVIAVASALQCIFSICLIFGAETNRPLLFLPWLIFNPISIVAYVITTIIGMVQHSTINNTYFIVGHLMVGLGVCQYSTSKDIANGFADYFSGVYDQIASSYNIETAIEQSHYERLHLSSITVADVSEALKRLKPKKSVGPDRVPPYVYKACAEHLTYPLLVIFNLMIKTGTFPEAWKTHCVVIDTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AQN6</accession>
    <name>A0A5N4AQN6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pseudouridine synthase I TruA alpha/beta domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_07520</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AQN6"/>
    <dbReference type="FunCoup" id="A0A5N4AQN6">
        <property type="interactions" value="2031"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AQN6"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02569">
        <property type="entry name" value="PseudoU_synth_ScPus3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.580:FF:000007">
        <property type="entry name" value="tRNA pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00171">
        <property type="entry name" value="TruA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020097">
        <property type="entry name" value="PsdUridine_synth_TruA_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020095">
        <property type="entry name" value="PsdUridine_synth_TruA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041707">
        <property type="entry name" value="Pus3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00071">
        <property type="entry name" value="hisT_truA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142:SF5">
        <property type="entry name" value="TRNA PSEUDOURIDINE(38_39) SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01416">
        <property type="entry name" value="PseudoU_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pseudouridine synthase I TruA alpha/beta" evidence="4">
        <location>
            <begin position="196"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0799640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="409" mass="47960" checksum="15CA570926F4184D" modified="2020-02-26" version="1">MLQSWYHVYLFQDLIDKIIALQCHNVELKNIIAKSQQRNQKRSYPPQKPFDFTRCKFRHVLLQVLYLGWDYQGYACQEDSLNTIEHFLFEALLKTCLIKDRQSSNYHRCGRTDKGVSAFGQVISLDLRSNNHDLDREINYCIILNKVLPPAIRCVAWCPVSDNFSARFNCTLRKYKYFFPKGFLNIQKMVEGTQFLVGSHDFRNFCKMDVGNGVVKYNRTITHVDILPYSLNKENEEYSMFVLVIQGQAFLWHQIRCIMGVLLLIGQEKEDPSIVKDLLDVEKHSRKPDYNMASDIPLNLYDCEYELESNWRYDDNNLTDLIKKLQSFWTFHAIKANMVESMLLDLRKRSGSTVDLSLCQSNYLLNGVRAKKYVPLVQRQKCESLENRIQHFIKRRKLEGSNSSPVVDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AR28</accession>
    <name>A0A5N4AR28_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_07603</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AR28"/>
    <dbReference type="InParanoid" id="A0A5N4AR28"/>
    <dbReference type="OrthoDB" id="6156669at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031521">
        <property type="entry name" value="DUF4695"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15766">
        <property type="entry name" value="DUF4695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="104"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0799723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="120" mass="13566" checksum="FC824417E2F9032B" modified="2020-02-26" version="1">MPSCTSTTPVMDTVYPEPMSRLHRRVVPKRRAGPSSRYRTQPITFSEIQEVDEENVEDAVPKPSSSKSELSLLHNKFEEFKKSRDLILGKNDAEYTEVSKNPVPLSSSRSTSRLPSRTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ARC9</accession>
    <name>A0A5N4ARC9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Pickpocket protein 28</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PPYR_07736</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ARC9"/>
    <dbReference type="InParanoid" id="A0A5N4ARC9"/>
    <dbReference type="OrthoDB" id="6502088at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015280">
        <property type="term" value="F:ligand-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.470.10">
        <property type="entry name" value="Acid-sensing ion channels like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.770">
        <property type="entry name" value="YojJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF288">
        <property type="entry name" value="AMILORIDE-SENSITIVE NA+ CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01078">
        <property type="entry name" value="AMINACHANNEL"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="4 12" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="10 12" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="484"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAB0799856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="538" mass="61769" checksum="354F94E485A76A6E" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ARU9</accession>
    <name>A0A5N4ARU9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mitochondrial import inner membrane translocase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_07818</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small Tim family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ARU9"/>
    <dbReference type="FunCoup" id="A0A5N4ARU9">
        <property type="interactions" value="1477"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4ARU9"/>
    <dbReference type="OrthoDB" id="344165at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim13 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004217">
        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="1" id="KW-0653">Protein transport</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0811">Translocation</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Tim10-like" evidence="2">
        <location>
            <begin position="26"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0799938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="93" mass="10576" checksum="6064A484F1091974" modified="2020-02-26" version="1">MTDFGDSFAPPPPQGKDDKELQEFLFVEKQKAQFNAQIHEFNDFCWDKCVEKPGSKLDSKTETCLTNCVDRFIDVSLLITNRFAQLLQKSGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ARX8</accession>
    <name>A0A5N4ARX8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MD-2-related lipid-recognition domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_07982</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0800102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ARX8"/>
    <dbReference type="InParanoid" id="A0A5N4ARX8"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010512">
        <property type="entry name" value="DUF1091"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21112">
        <property type="entry name" value="CHEMOSENSORY PROTEIN A 29A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21112:SF0">
        <property type="entry name" value="CHEMOSENSORY PROTEIN A 29A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06477">
        <property type="entry name" value="DUF1091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0800102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="188" mass="22466" checksum="586D1EA9C6F4B1E6" modified="2020-02-26" version="1">MKSVMSNIRIVYYFVLFSTFACDFPKYFQNDYVMKYERHLVHFYNEKYIRYNLTYSKVSKTSRRFLFTVDVLQDIGSNIKVVLEALKFTSNEYRRFGFRYEEHPCSFTFNSPFGFSYKNSDTNLTTCPTKKGSYYLRDLNLDQSKFPPFVPRGRFMLNGYLYVDDILLTNMSFYIKIVPTDPLEVVIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ASJ1</accession>
    <name>A0A5N4ASJ1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cyclin-dependent kinase</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PPYR_06075</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="VVIM01000004">
        <property type="protein sequence ID" value="KAB0800335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ASJ1"/>
    <dbReference type="FunCoup" id="A0A5N4ASJ1">
        <property type="interactions" value="785"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4ASJ1"/>
    <dbReference type="OrthoDB" id="647at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040019">
        <property type="term" value="P:positive regulation of embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07843">
        <property type="entry name" value="STKc_CDC2L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000533">
        <property type="entry name" value="cyclin-dependent kinase 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000054">
        <property type="entry name" value="Cyclin-dependent kinase 11B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045267">
        <property type="entry name" value="CDK11/PITSLRE_STKc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF107">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 11A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="270"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="8"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="34"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="70"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="94"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAB0800335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="616" mass="71150" checksum="ABC647F5F34C9BC4" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ASJ7</accession>
    <name>A0A5N4ASJ7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">V-type proton ATPase subunit a</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PPYR_05993</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the V-ATPase 116 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000004">
        <property type="protein sequence ID" value="KAB0800253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ASJ7"/>
    <dbReference type="FunCoup" id="A0A5N4ASJ7">
        <property type="interactions" value="1032"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4ASJ7"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000220">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051117">
        <property type="term" value="F:ATPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002490">
        <property type="entry name" value="V-ATPase_116kDa_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026028">
        <property type="entry name" value="V-type_ATPase_116kDa_su_euka"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629:SF63">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629">
        <property type="entry name" value="VACUOLAR PROTON ATPASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01496">
        <property type="entry name" value="V_ATPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001293">
        <property type="entry name" value="ATP6V0A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 9" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="401"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="450"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="538"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="571"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="645"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="777"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="690"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="51"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAB0800253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="845" mass="96758" checksum="57AD78772E8E470D" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AT80</accession>
    <name>A0A5N4AT80_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="6">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_06203</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="VVIM01000004">
        <property type="protein sequence ID" value="KAB0800463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AT80"/>
    <dbReference type="InParanoid" id="A0A5N4AT80"/>
    <dbReference type="OrthoDB" id="19653at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142:SF1">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024345459" description="Carboxylic ester hydrolase" evidence="7">
        <location>
            <begin position="16"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="8">
        <location>
            <begin position="20"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0800463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="554" mass="62452" checksum="EA22709B27AC82A1" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ATB9</accession>
    <name>A0A5N4ATB9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Retinol dehydrogenase 12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_06317</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000004">
        <property type="protein sequence ID" value="KAB0800577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ATB9"/>
    <dbReference type="InParanoid" id="A0A5N4ATB9"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF73">
        <property type="entry name" value="WW DOMAIN-CONTAINING OXIDOREDUCTASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0800577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="313" mass="34519" checksum="A17501FB0CBEB40C" modified="2020-02-26" version="1">MGISHTKFTPNVRLNTKTAIITGANTGLGKAVARDFYKRGARVIMACRNMEKGNQAAKDIKISCTDEKLVGELVLADLDLSSLKSIRDCACKLLNDEKRINILVNNAGVMMCPKSQTSDGFETQLGTNHLGHFLFTLLLLPRIISSAPSRIINVSSKGHTFGRIDFDDLNFERSKYSAFGAYSQSKLANILFAKELARQLEENGIDGVSTYSVHPGVVSTELGRHLNKTYFTGLSKAIRLLMGRFFKTAEEGAQTIVYCALSVEAGKETGLYYYNCETVKPAGAAENMEDAKKLWEESIKLVKLENYNPFTSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2024-10-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AU57</accession>
    <name>A0A5N4AU57_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Saposin A-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_05228</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GILT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000003">
        <property type="protein sequence ID" value="KAB0800874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AU57"/>
    <dbReference type="InParanoid" id="A0A5N4AU57"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016671">
        <property type="term" value="F:oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004911">
        <property type="entry name" value="Interferon-induced_GILT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13234">
        <property type="entry name" value="GAMMA-INTERFERON INDUCIBLE LYSOSOMAL THIOL REDUCTASE GILT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13234:SF8">
        <property type="entry name" value="GAMMA-INTERFERON-INDUCIBLE LYSOSOMAL THIOL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03227">
        <property type="entry name" value="GILT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024330307" description="Saposin A-type domain-containing protein" evidence="6">
        <location>
            <begin position="22"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0800874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="219" mass="24820" checksum="AC43A7BB4DEA8785" modified="2020-02-26" version="1">MMKLSLITILLTLIILVKCSSSKFEKQKLKVSLYYETLCPFCMTFINDQLYPGYQKLGDYLDLELIPYGNARRKKTDNGWTIECQHGPKECVYNKIEACGMARNVDQNAVISFVHCIEKGIKTDDSNYKRITKKCGPLLNVNTADIIKCAEGQEGDELMVANGVKTDAVQPSIDGVPTVLYNNYYNDTLEEYNDNFLTIACKLLDDEPAACMHLDNEIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AUB2</accession>
    <name>A0A5N4AUB2_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_05319</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000003">
        <property type="protein sequence ID" value="KAB0800965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AUB2"/>
    <dbReference type="InParanoid" id="A0A5N4AUB2"/>
    <dbReference type="OrthoDB" id="8250900at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0800965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="120" mass="13054" checksum="A8792087F75A96C7" modified="2020-02-26" version="1">MEIRIVVFLMAAGLAYGSVIYSSNLNSALVNFKQLGGNFAYSSFEFPTYLGPTVLRQVIGQYPFYPPQQVLYPGYPIFTYPGLPIQGPVSPPFITQQKPPSSGSPSQVIIDEDTVAIDSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AUZ0</accession>
    <name>A0A5N4AUZ0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FLYWCH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_05412</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000003">
        <property type="protein sequence ID" value="KAB0801058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AUZ0"/>
    <dbReference type="InParanoid" id="A0A5N4AUZ0"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007588">
        <property type="entry name" value="Znf_FLYWCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47160:SF5">
        <property type="entry name" value="MULE TRANSPOSASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47160">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04500">
        <property type="entry name" value="FLYWCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FLYWCH-type" evidence="4">
        <location>
            <begin position="16"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0801058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="403" mass="46601" checksum="F4C77C3DE96CDF89" modified="2020-02-26" version="1">MGILHCKESALPVQIIISKRGKQKLVYENHLYLFSKKTRDNINAIWVCEKRSTCKGRVWTEGMNGEVIKVVNLHNHAAQAARPEAVRLVNEVCTRARTTQETPQQILAEVVSEAHANVAALLPRKDSLKRSIRAMRKVGNMPRLPQTIDQLNIPQEFREINIDGTLHQFLLWDSVGTGKGCFRQLPETGSIKIGFSMFDEEFPNIEKTGCFFHLSQSVWRKVQNEGLKARYQNDHEFSRWIRMIPSLAFLPPDRVTQSFEDLLDDPDFPQEALPIANYFEDTYIGRINRRGRQAPLFPIQFWNVYQRTLNGQHRTNNDVEGWHRSFQETCGSLFPNIYRFINCLKRQQGLHNFEMVQVLAGNAPTARNKKYAVISARVLRIVEDLGNRNLIDYLRGIAYNFEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AV22</accession>
    <name>A0A5N4AV22_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_05569</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000003">
        <property type="protein sequence ID" value="KAB0801215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AV22"/>
    <dbReference type="InParanoid" id="A0A5N4AV22"/>
    <dbReference type="OrthoDB" id="1730117at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17491">
        <property type="entry name" value="MFS_MFSD12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000431">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039672">
        <property type="entry name" value="MFS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11328">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11328:SF28">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13347">
        <property type="entry name" value="MFS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="296"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="329"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="359"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="392"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="425"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0801215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="481" mass="53252" checksum="0ADDE4F97B1109DD" modified="2020-02-26" version="1">MDTSGSGAVMDSGEYTEVYRRLPLKLQLAYGMGHVLNDVCASMWFTYLLVFFHLVLEFSNWEAGFMLLVGQVADALSTPFVGFHSDQSDNIWLCRYGRRKTWHLLGSICVISSFPFIFSPCLNCSGSHSWAQMIYFSVFIIIFQFGWASIQISHLSLIPELTPNEHDRTKLTAIRYGFTVLSNVLVYIITWYVLHLNGGTNEGQIGPADASKFQTVVWTGLSIGVFCTIIFHIFVKEQNDYGGDNVHAGQLRTSISEIFKNLQIYQVAVTYMATRLFVNLSQVFIPLYLHETLNMVASALALIPLIMYIGSFVTSMCIEKLNRSFGRRFAYVIGSALSLVACCWIGVRSGPQYTDYEIYVVAVLFGAGGSIILVTSLGITADLIGDKTGNGAFIYGIMSFTDKLANGVAVIIIQDLHKNNSDVTYYRNTITFVCGGSAILGALSVISLIKRRQDNSLFGETPNYVSINSDASPSEIQPLIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AWM6</accession>
    <name>A0A5N4AWM6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_03951</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0801765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AWM6"/>
    <dbReference type="InParanoid" id="A0A5N4AWM6"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048366">
        <property type="entry name" value="TNP-like_GBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048367">
        <property type="entry name" value="TNP-like_RNaseH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048365">
        <property type="entry name" value="TNP-like_RNaseH_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47577:SF2">
        <property type="entry name" value="THAP DOMAIN CONTAINING 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47577">
        <property type="entry name" value="THAP DOMAIN-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21788">
        <property type="entry name" value="TNP-like_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21789">
        <property type="entry name" value="TNP-like_RNaseH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21787">
        <property type="entry name" value="TNP-like_RNaseH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposable element P transposase-like RNase H" evidence="1">
        <location>
            <begin position="251"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="Transposable element P transposase-like GTP-binding insertion" evidence="2">
        <location>
            <begin position="407"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="Transposable element P transposase-like RNase H C-terminal" evidence="3">
        <location>
            <begin position="595"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0801765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="689" mass="78634" checksum="FAD2A2CC14A90767" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AWT2</accession>
    <name>A0A5N4AWT2_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">H15 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PPYR_03980</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the histone H1/H5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0801794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AWT2"/>
    <dbReference type="InParanoid" id="A0A5N4AWT2"/>
    <dbReference type="OrthoDB" id="6361449at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00073">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000140">
        <property type="entry name" value="Histone H1.0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005819">
        <property type="entry name" value="H1/H5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005818">
        <property type="entry name" value="Histone_H1/H5_H15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00538">
        <property type="entry name" value="Linker_histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00624">
        <property type="entry name" value="HISTONEH5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00526">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51504">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="H15" evidence="9">
        <location>
            <begin position="50"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="118"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="123"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="144"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="170"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="190"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="224"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0801794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="261" mass="26086" checksum="773C2DA90BF19965" modified="2020-02-26" version="1">MADTAVANQASEASTGGGGASPPAAAKKAVASSSQQQKKGTKGGARSKPSHPPTADMVNGAIKSLKERGGSSLQAIKKYLVTTYKIDAEKMAPFIKKYIKGAVASGALIQTKGKGASGSFKLAADAASPSSGGSAAKGRKKRVAAAVAATKRQKAAVSPAKKASPAASVKKPKSSPKKKKAPATASPQRKVAKAAAAKKRTGASASSAPETQAAAASSPSKPKSPSKAKKTTKVPTKKPKAPKPKKAKQTKKPATGSPKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AXI9</accession>
    <name>A0A5N4AXI9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serpin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_04154</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the serpin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0801968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AXI9"/>
    <dbReference type="FunCoup" id="A0A5N4AXI9">
        <property type="interactions" value="35"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AXI9"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19601">
        <property type="entry name" value="serpin42Da-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.39.10">
        <property type="entry name" value="Alpha-1-antitrypsin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.497.10">
        <property type="entry name" value="Antithrombin, subunit I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023795">
        <property type="entry name" value="Serpin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023796">
        <property type="entry name" value="Serpin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000215">
        <property type="entry name" value="Serpin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036186">
        <property type="entry name" value="Serpin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042178">
        <property type="entry name" value="Serpin_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042185">
        <property type="entry name" value="Serpin_sf_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461:SF211">
        <property type="entry name" value="GH10112P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR, SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00079">
        <property type="entry name" value="Serpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00093">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56574">
        <property type="entry name" value="Serpins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00284">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024276891" description="Serpin domain-containing protein" evidence="5">
        <location>
            <begin position="16"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="Serpin" evidence="6">
        <location>
            <begin position="30"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0801968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="381" mass="43576" checksum="858A360185A5439B" modified="2020-02-26" version="1">MKFLLLCVIFTVINSEEIQEFQDSNLQFATDIYKQISKRNTENFLICPLSAQIVLSLATVGARENSAKQLSNCLYLPNDSVKIQSIFQKLNNNFDVTKPYQFSSANKIYLNNKCEIKSHYRDIAINTFKAGIENINFSETEKATKIINQWVESKTNSKIKDLIQKNTIQSNTFAILVNALYFHGDWVNEFGYSGDYKQDFYVSENETVSVNYMTQRNYFNYCYNEKLHAEFLELPFVGDDITMTIVLPKDTHGLKKLENHISSVISPQRLAKSDALITIPKFKMESTIDFKQVLKELGVTDPFNTKANFKGITEAPIYIDEVVQKTFIEINEKGTTAAAATKISFGSISMPLVTFTADHPFIYYLRHRTTGIVFIGRFSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AXN1</accession>
    <name>A0A5N4AXN1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PPYR_04262</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AXN1"/>
    <dbReference type="InParanoid" id="A0A5N4AXN1"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021896">
        <property type="entry name" value="THAP9-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052224">
        <property type="entry name" value="THAP_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048366">
        <property type="entry name" value="TNP-like_GBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048365">
        <property type="entry name" value="TNP-like_RNaseH_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46927">
        <property type="entry name" value="AGAP005574-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46927:SF3">
        <property type="entry name" value="THAP-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21788">
        <property type="entry name" value="TNP-like_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21787">
        <property type="entry name" value="TNP-like_RNaseH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12017">
        <property type="entry name" value="Tnp_P_element"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00692">
        <property type="entry name" value="DM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="7">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="133"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0802076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="575" mass="66653" checksum="4045B4325C095232" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AXX7</accession>
    <name>A0A5N4AXX7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">TIR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PPYR_04373</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Toll-like receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AXX7"/>
    <dbReference type="FunCoup" id="A0A5N4AXX7">
        <property type="interactions" value="74"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AXX7"/>
    <dbReference type="OrthoDB" id="1421090at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10140:FF:000020">
        <property type="entry name" value="Blast:Protein toll"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001164">
        <property type="entry name" value="GH01279p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000727">
        <property type="entry name" value="Toll-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="entry name" value="Toll/interleukin-1 receptor homology (TIR) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000483">
        <property type="entry name" value="Cys-rich_flank_reg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000372">
        <property type="entry name" value="LRRNT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24365:SF541">
        <property type="entry name" value="PROTEIN TOLL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24365">
        <property type="entry name" value="TOLL-LIKE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01582">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01537">
        <property type="entry name" value="INTRLKN1R1F"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00082">
        <property type="entry name" value="LRRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00013">
        <property type="entry name" value="LRRNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00255">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="Toll/Interleukin receptor TIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50104">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 12" id="KW-0732">Signal</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024437875" description="TIR domain-containing protein" evidence="12">
        <location>
            <begin position="23"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="783"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="domain" description="TIR" evidence="13">
        <location>
            <begin position="836"/>
            <end position="972"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAB0802187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1051" mass="120888" checksum="6DB6CF47F4536104" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AYZ2</accession>
    <name>A0A5N4AYZ2_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">YqaJ viral recombinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_04751</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AYZ2"/>
    <dbReference type="FunCoup" id="A0A5N4AYZ2">
        <property type="interactions" value="12"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AYZ2"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd22343">
        <property type="entry name" value="PDDEXK_lambda_exonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019080">
        <property type="entry name" value="YqaJ_viral_recombinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39953">
        <property type="entry name" value="RE54151P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39953:SF1">
        <property type="entry name" value="RE54151P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09588">
        <property type="entry name" value="YqaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YqaJ viral recombinase" evidence="1">
        <location>
            <begin position="205"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0802565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="389" mass="42947" checksum="073D9250D4D82C13" modified="2020-02-26" version="1">MADPGFVKAQSDNLPHVDALMVAEFFASSDKYTAAEIRGLKAMRAGRESYGDAAVGYVQIQRSQNVCTIKCRLCPEHRVRQKNYSVVVVIDEVEEKILSADCQDCAAGAGGCKHAVAFVMWLHRRSEEPSPTDVESYWRKSKLAGVGTSLKYITVKNFGAAEDTPAGSSVGAPLLARLIEGKRMTPEICNKCFIATKEQSSSVLWHELRYARITASKVYEAARCKTLSGSLVESIFGAKLKETAAINRGKLLEDEVLSVLQKQLNMKFSKVGLMLSGKYPVLGASPDAVNEEFVVEVKCPSSEKAVNAYVTKDNKIVNKYRAQIQLQMLVNNKKSGIFCVADTNFESNKVITVVRDEYDHDFIQPIIEMAVDFWKAAIFPKVLNSLPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AZT3</accession>
    <name>A0A5N4AZT3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mitochondrial import inner membrane translocase subunit TIM50</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PPYR_05048</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">1611_PpyrPB1</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 14">Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the TIM23 complex at least composed of Tim23, Tim17 (Tim17a1, Tim17a2 or Tim17b1) and a Tim50.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Mitochondrion inner membrane</location>
            <topology evidence="2 14">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the TIM50 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AZT3"/>
    <dbReference type="FunCoup" id="A0A5N4AZT3">
        <property type="interactions" value="2314"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AZT3"/>
    <dbReference type="OrthoDB" id="287041at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000019">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit TIM50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7 14" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 14" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="10 14" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 14" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FCP1 homology" evidence="15">
        <location>
            <begin position="160"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00061911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU365079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAB0802862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="366" mass="41612" checksum="FFB7E71038CFF291" modified="2020-02-26" version="1">MFIRRVFALFIQLPNKSSAQFLVKRSIPIVQQNRILSKVVNSKIGEQQTQISGYLTESPLISSHLNGDGTAANREAAWRTIKYTLLLSATAVLGTGIYLVVKFGKPQAAENGLLIPDEFYAQPTPLQYIRRALKVLEGYVRLISEPSREKLLPDELNPPYYQPPFTLVLELTDVLVHPDWTYQTGWRFKKRPGVEYLLETLSGLYEIVIYTAEQGMTVFPIVEALDPKNLIMYKLVRDATNFVDGAHVKDLNKLNRDLSRVIVVDWNANSAKFHPDNVFQIPRWDGNDNDTSLIDLTALLVTIAHSGVEDVREVINYYKDFDDGLAAFREKRNAILEDQDLRPNTPSESPIQKLSKNLFAKQHKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AZX9</accession>
    <name>A0A5N4AZX9_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_05093</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CWC16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AZX9"/>
    <dbReference type="InParanoid" id="A0A5N4AZX9"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007590">
        <property type="entry name" value="Saf4/Yju2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111">
        <property type="entry name" value="SPLICING FACTOR YJU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111:SF2">
        <property type="entry name" value="SPLICING FACTOR YJU2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04502">
        <property type="entry name" value="Saf4_Yju2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0802907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="169" mass="18975" checksum="4ABCE4883614B4CE" modified="2020-02-26" version="1">MFKLEHGTDDQNYAENAKTALVNLYNRNESTWADDYSANCMLRQAFRKNKNDFKTSIAKDNALLKKSSLNIKLVPEAEEDKQLAAVLSLKLKPKLDAEKTTELIRKNIISESSLPCTSFTPAKERKAIKVLNNNDLKKLVLINKPTQAKKIKLTPSLVGDYGNSTSESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B1Z1</accession>
    <name>A0A5N4B1Z1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4806 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_00508</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B1Z1"/>
    <dbReference type="InParanoid" id="A0A5N4B1Z1"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34153:SF2">
        <property type="entry name" value="SI:CH211-262H13.3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34153">
        <property type="entry name" value="SI:CH211-262H13.3-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0803538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="481" mass="55265" checksum="BA8DC869F8F741EC" modified="2020-02-26" version="1">MLKSNTHFNSYNVCRTSLPIAFYHFNECTDNTRFGTIKFMDFVKVKVNNRTALPALSSATRLSLFTEIHTILINTLRLRFTCLPWPWHPSLGPNCFCLFIMDMDSLNSTWSVVKFPKENSVCVVPTSWIHKDKCYWPPYNDKLTRTAIEKHESFNAQTWLEFPCEPFRNATYDTFKEANRKSQIAMTTSDLESSAEAGATTVSSRKRKIFRKTFSFSSIDEENEESVLPEPPKLTIRETFERRADEPQHSSCSAASIDVECEELILPELHTANKRKENSQTRDDTMVETTMQGQTRGQSIKAISRKGDGHGQDGTQTIKYLQQIIKKQNILQSILMDISNRITNLESQNSTQTQENVDDNAESFFVIMTNLPIDSQEHLNDLEMYLSTPEHMESAVKEVSHIGGKDTYDFVFRATQKLITNNFCGSTFSFLGRRKKEPFTKLKLNELLIKSSMHLFPSATLKDVEGSITKWLRRCLERSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B2N9</accession>
    <name>A0A5N4B2N9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">CD109 antigen</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_00851</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A5N4B2N9">
        <property type="interactions" value="34"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4B2N9"/>
    <dbReference type="OrthoDB" id="6359008at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004866">
        <property type="term" value="F:endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.130.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1930">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.690">
        <property type="entry name" value="Alpha-macroglobulin, receptor-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009048">
        <property type="entry name" value="A-macroglobulin_rcpt-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036595">
        <property type="entry name" value="A-macroglobulin_rcpt-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050473">
        <property type="entry name" value="A2M/Complement_sys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011625">
        <property type="entry name" value="A2M_N_BRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011626">
        <property type="entry name" value="Alpha-macroglobulin_TED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001599">
        <property type="entry name" value="Macroglobln_a2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002890">
        <property type="entry name" value="MG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041555">
        <property type="entry name" value="MG3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412:SF172">
        <property type="entry name" value="LD23292P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412">
        <property type="entry name" value="MACROGLOBULIN / COMPLEMENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00207">
        <property type="entry name" value="A2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07703">
        <property type="entry name" value="A2M_BRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07677">
        <property type="entry name" value="A2M_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01835">
        <property type="entry name" value="MG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17791">
        <property type="entry name" value="MG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07678">
        <property type="entry name" value="TED_complement"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01360">
        <property type="entry name" value="A2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01359">
        <property type="entry name" value="A2M_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01361">
        <property type="entry name" value="A2M_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49410">
        <property type="entry name" value="Alpha-macroglobulin receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024312120" description="CD109 antigen" evidence="5">
        <location>
            <begin position="21"/>
            <end position="1754"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1729"/>
            <end position="1751"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-2-macroglobulin bait region" evidence="6">
        <location>
            <begin position="637"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-2-macroglobulin" evidence="7">
        <location>
            <begin position="909"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-macroglobulin receptor-binding" evidence="8">
        <location>
            <begin position="1607"/>
            <end position="1698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="372"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="856"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="868"/>
            <end position="883"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0803881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1754" mass="202008" checksum="CC5A08F50A6FBC63" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B342</accession>
    <name>A0A5N4B342_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase M13 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_00918</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B342"/>
    <dbReference type="InParanoid" id="A0A5N4B342"/>
    <dbReference type="OrthoDB" id="6766519at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF167">
        <property type="entry name" value="FI17812P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="28"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="4">
        <location>
            <begin position="80"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0803948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="633" mass="73644" checksum="CA843F088D88EFB0" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B376</accession>
    <name>A0A5N4B376_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Photoreceptor-specific nuclear receptor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Nuclear receptor subfamily 2 group E member 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Retina-specific nuclear receptor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PPYR_00984</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">1611_PpyrPB1</strain>
            <tissue evidence="20">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Orphan nuclear receptor of retinal photoreceptor cells. Transcriptional factor that is an activator of rod development and repressor of cone development. Binds the promoter region of a number of rod- and cone-specific genes, including rhodopsin, M- and S-opsin and rod-specific phosphodiesterase beta subunit. Enhances rhodopsin expression. Represses M- and S-cone opsin expression.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the nuclear hormone receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B376"/>
    <dbReference type="FunCoup" id="A0A5N4B376">
        <property type="interactions" value="103"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4B376"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06970">
        <property type="entry name" value="NR_DBD_PNR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06950">
        <property type="entry name" value="NR_LBD_Tlx_PNR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.565.10:FF:000022">
        <property type="entry name" value="Nuclear receptor subfamily 2 group E member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000028">
        <property type="entry name" value="Nuclear receptor subfamily 2, group E, member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050274">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24083">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 16" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="3 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10 16" id="KW-0675">Receptor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 16" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 16" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="5 16" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="18">
        <location>
            <begin position="85"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="19">
        <location>
            <begin position="261"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="219"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="238"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="256"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00053319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00071097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00079595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00082944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU004334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAB0804014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="477" mass="52496" checksum="3759274909F497E0" modified="2020-02-26" version="1">MNLTTTSIEQVTALLPSLHQSCASPSENHHLHNDVRGSPGNVDCYSSAPEDHPLSLSLQGSQTLVQASRTPPPPWSFPTKKGTPGLVCVVCGDTSSGKHYGILACNGCSGFFKRSVRRKLIYRCQAGTGRCIVDKAHRNQCQACRLKKCLSMGMNKDAVQNERQPRNTATIRPESLREMSAEQERALREAAVAVGVFGPPVSLTMALSSPVRYGPSLLPPVPPPPVINREPSPKQETSDNDEESIDVTNEEEDAPSSGCGVSSSSGPFRHEPHQITSGLSTIGIYPSTHETIYETSARLLFMAVKWAKNLPSFASLPFRDQVILLEEAWSELFLLNAIQWCMPLDAVSSSLFNPNEHTKNGQGAADVRILCDTLMRFKAVHVDPAEFACLKAIVLFRAETRGLKDPSQIENLQDQAQVMLWQHCRTQLPAQVARFGRLLLMLPLLRIVPAIRVEAVFFQKTIGNTPMEKVLCDMYKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2024-07-24" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B481</accession>
    <name>A0A5N4B481_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF659 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_01372</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B481"/>
    <dbReference type="InParanoid" id="A0A5N4B481"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0804402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="231" mass="26022" checksum="89AF8ED6FFB9466B" modified="2020-02-26" version="1" fragment="single">FYIANLLVGVLDTDEPQKPFLIACKRLPTTNFETICQFINKSLTAFSSTINGRVLLLLTDAAPYMVKAAKTEAHGINRVAEVARELCPGVNKLVNNGKKAFLKAPSRVAIYKEIMPDSPLPPEPIITRWGTWLEAAIFYANNYEKFAAVVRRLEDDAESVKKLKLLIEERSVQNELIFIKTHLCFLPECLKQLENQGMSLYDSISIVQDVKSKIIRIPGEKGKRLKSKLDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B5J2</accession>
    <name>A0A5N4B5J2_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_01845</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B5J2"/>
    <dbReference type="InParanoid" id="A0A5N4B5J2"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF269">
        <property type="entry name" value="NUCLEASE HARBI1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="8">
        <location>
            <begin position="62"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0804875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="141" mass="16330" checksum="B258571D39062382" modified="2020-02-26" version="1">MDLHYSFRIASTTIGKIVRDVCRNIWIHMKDMCMEQLTEDKWKDIINGFKKTAKFPNCLGPVDGKHIKIIQPAQSGSAYYNYKNYFSIILLAVCDNNYMFTFVDIGSYGRHADSTIFEESCLYKMLQEKKLNIPPPSTISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B5U6</accession>
    <name>A0A5N4B5U6_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_01957</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B5U6"/>
    <dbReference type="InParanoid" id="A0A5N4B5U6"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0804987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="103" mass="11549" checksum="C610CF99CB0FADA4" modified="2020-02-26" version="1">MLSTNNSIPIPCNSTSYSHIDPSTASENTEENVLTVNATNPVTMLTNTKSPKKTVSYASNQEFQFSNQKLQQGLSLNIRGYDDQATFNFHFHYSNSTNDNEKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B7P0</accession>
    <name>A0A5N4B7P0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UDP-glucuronosyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PPYR_01058</name>
        <name evidence="7" type="ORF">PPYR_02601</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:132367"/>
            <dbReference type="ChEBI" id="CHEBI:132368"/>
            <dbReference type="EC" id="2.4.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Membrane</location>
            <topology evidence="5">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.17" evidence="5"/>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0805631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B7P0"/>
    <dbReference type="InParanoid" id="A0A5N4B7P0"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015020">
        <property type="term" value="F:glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000050">
        <property type="entry name" value="UDP-glucuronosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035595">
        <property type="entry name" value="UDP_glycos_trans_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF159">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00375">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="468"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0804088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0805631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="509" mass="58378" checksum="0E427042D0CE5193" modified="2020-02-26" version="1">MNVVLLLLIRMALSANILYIVPLGSPSHVIWNRALAVSLNDKGHNVTMVTHTEEKQKIKNFHTILLEGFYEKKYEAHSLESLSKRDAFSNIKARYDYSFYSCVHDLETEGFKTLLNYPKDFNFALIIFDITNEGCLYPLIQRFNNPPVVAVTTFLLSPALAHVFGNPMQAAYFPFYSTKHTDRMIFVERMKNFLLIHFEILYRRYISLPAELKLAKQYFGENIRDFEEVERNMSLLICNYDPLLSFPLALAPNIVPAGGLHIEPVKPLPVDLKKIVEDAQEGLVIFALGSYFRSDQLSITKRTAILDAFAKLPQTVLWKFESEITDLPKNVFVRKWLPQNDLLGNCKTKLLITHGGALSTQEAMYHGVPVIVVPFFIDQHANGEKLADRRMGKVVSYHDITSENLFAAITEVINNPMYSKNIKQLSQLYRDSPDHPLERAVYWVEFVLRHGTAKHFNLASRDMSTYQLASYDVVLVLLLGLFLLYELTLFIFTCCRWTYSIKSPVNIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1K3X0</accession>
    <name>A0A1Y1K3X0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MADF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_07759</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01099031">
        <property type="protein sequence ID" value="JAV53557.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1K3X0"/>
    <dbReference type="FunCoup" id="A0A1Y1K3X0">
        <property type="interactions" value="7"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1K3X0"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21505">
        <property type="entry name" value="MADF DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21505:SF12">
        <property type="entry name" value="MADF DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00595">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51029">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MADF" evidence="2">
        <location>
            <begin position="10"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="JAV53557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0799879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="259" mass="29447" checksum="349C607A6486C38C" modified="2017-08-30" version="1">MSWSREQVTMLIEVYKNHPCLYVVKSPQYKNKHARNAALTDICSKLEAVKAGVTIADVKNKFAALRQNFLVEYRKHENSMKSGSGTDQVYIPTIWYYDLMLFVLEHSIAKTAIYDSIPKPLSPSLSSDSNIESLEFTDISQLEVVYEDEPDDSQTEEEPVNGGASNVHVIEQTPQTSRPQSQLKRKKGNEIDYLADASRAINEIANAVARKKPDVSTIKADRIDVFLKYIEPKLRRIKNDDLLDKIESDIVHIISKNFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1KNJ4</accession>
    <name>A0A1Y1KNJ4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Glyceraldehyde-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="12">1.2.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PPYR_12988</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">1611_PpyrPB1</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">1611_PpyrPB1</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 12">
            <text>D-glyceraldehyde 3-phosphate + phosphate + NAD(+) = (2R)-3-phospho-glyceroyl phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10300"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="1.2.1.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 1/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 12">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.12" evidence="12"/>
    <dbReference type="EMBL" id="GEZM01080423">
        <property type="protein sequence ID" value="JAV62148.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01080422">
        <property type="protein sequence ID" value="JAV62149.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1KNJ4"/>
    <dbReference type="InParanoid" id="A0A1Y1KNJ4"/>
    <dbReference type="OrthoDB" id="1152826at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00184"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004365">
        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019682">
        <property type="term" value="P:glyceraldehyde-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd18126">
        <property type="entry name" value="GAPDH_I_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05214">
        <property type="entry name" value="GAPDH_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000001">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000266">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020831">
        <property type="entry name" value="GlycerAld/Erythrose_P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020830">
        <property type="entry name" value="GlycerAld_3-P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020829">
        <property type="entry name" value="GlycerAld_3-P_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020828">
        <property type="entry name" value="GlycerAld_3-P_DH_NAD(P)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006424">
        <property type="entry name" value="Glyceraldehyde-3-P_DH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01534">
        <property type="entry name" value="GAPDH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10836">
        <property type="entry name" value="GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10836:SF76">
        <property type="entry name" value="GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02800">
        <property type="entry name" value="Gp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00044">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000149">
        <property type="entry name" value="GAP_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00078">
        <property type="entry name" value="G3PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00846">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00071">
        <property type="entry name" value="GAPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5 9 12" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding" evidence="14">
        <location>
            <begin position="20"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="29"/>
            <end position="30"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Activates thiol group during catalysis" evidence="10">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="JAV62148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAB0793368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="363" mass="39719" checksum="B727BEEF60D436C2" modified="2017-08-30" version="1">MEGDRHEDVGNQNDKPKKMSKIGINGFGRIGRLVLRAAMQKGAQVLAINDPFVDLNYMVYLFKHDSTHGRYKGDVTTEDGCLVVNGNKIILFQERDPKAIPWASVGVEYVIEATGAFTTVEKASAHLEGGAKKVIISAYSPDAPTYVVGVNLDMYDPRHKVISNSSCTTNCLAPLAKVIHDNFEIIEGLTTTIHGVTSCQKTVDAACSKWRYGRGSLQNIIPAATVAATAVGKVIPSLTGKLHGLAFRIPTPNVAIVDLNVRLRKETTYEEIKAKVKEASEGPLRGILGYTEEELVSSDFNGDTHSAVFDAEAGIHLSDNFVKLVAWYDNEIGYSHRVIDLITHIQTKDEEYANGSFYQSCEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1KRD0</accession>
    <name>A0A1Y1KRD0_PHOPY</name>
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        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PPYR_13363</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01075803">
        <property type="protein sequence ID" value="JAV63953.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KAB0793743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
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        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
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            <begin position="20"/>
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            <begin position="33"/>
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            <end position="98"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="99"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="JAV63953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0793743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="169" mass="17927" checksum="B461D39AD6228348" modified="2017-08-30" version="1">MRTVLAVVLAILCTTGTAAAVDKRNHLTIGDVNGDTPLHLTVRLNDLNLTRLLLIAGADINAKNNAGIAPLHMAIYKSNVEMVKLLLEHGANVDAQTNRGNSPLHEAVAKKDVGIVTTLLKSGASLDIQNEAGNTPLLVTLQNGLQDIAQILITHSSSKVPLNFKVNAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1KUF2</accession>
    <name>A0A1Y1KUF2_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PPYR_12452</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the Msh homeobox family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01075192">
        <property type="protein sequence ID" value="JAV64218.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0795613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1KUF2"/>
    <dbReference type="InParanoid" id="A0A1Y1KUF2"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048598">
        <property type="term" value="P:embryonic morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050674">
        <property type="entry name" value="Msh_Homeobox_Regulators"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24338">
        <property type="entry name" value="HOMEOBOX PROTEIN MSX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24338:SF0">
        <property type="entry name" value="MUSCLE SEGMENTATION HOMEOBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 7 8" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="10">
        <location>
            <begin position="207"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="7">
        <location>
            <begin position="209"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="320"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="29"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="64"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="86"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="329"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="JAV64218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAB0795613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="343" mass="37991" checksum="45F96C5BB1A9305E" modified="2017-08-30" version="1">MLKKQTDSVQSMTIQSIDSLNTKNAETMQSLSEKSQNQQQQQTASKNGHISFSVASLLADTRPAKSTSPESHPNSSLSPQHHSSDDDYDSNQEDSIVDVEDLNCTDQKSDSLSKDSEHFLRQSQRERAEFQRDGMVNQGPIRPTPFSALAAAVYQAAHPNWAAQGLVTPFGGPGPMFQGPTPFGVPTITADSNGEGPKLKCNLRKHKPNRKPRTPFTTQQLLALEKKFRDKQYLSIAERAEFSSSLRLTETQVKIWFQNRRAKAKRLQEAEIEKLKMASLTRHPHPLYPHPALQGYFPPGAHPLASLLGARPPMAPLGIISQPPPHHLTSPQSSMRTPSPHMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1KZR6</accession>
    <name>A0A1Y1KZR6_PHOPY</name>
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        <recommendedName>
            <fullName evidence="4">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PPYR_04452</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acetyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01068526">
        <property type="protein sequence ID" value="JAV66909.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="FunCoup" id="A0A1Y1KZR6">
        <property type="interactions" value="152"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1KZR6"/>
    <dbReference type="OrthoDB" id="7305308at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000064">
        <property type="entry name" value="GNAT family acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
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        <property type="entry name" value="Diverse_Substrate_AcTransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10545">
        <property type="entry name" value="DIAMINE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10545:SF29">
        <property type="entry name" value="GH14572P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="7"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="JAV66909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0802266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="164" mass="18852" checksum="8DA4CE455A90A632" modified="2017-08-30" version="1">MEHRNNVIIRKAKKDDMYQVCQLIKELAIHEKCEQECVMTPEILIADGFASPDPPFKMFVADVNGQIVGYSAYFNGYRTNTGNFIFLQDLFVSLQYRNEGIGKKLFQSVAKVASKTASKRLELHCLSWNPSLEFYLKMGFRNTTEINGWNYLIIDGDNLSKHVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1L8T1</accession>
    <name>A0A1Y1L8T1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphatidylinositol-specific phospholipase C X domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_12693</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01066301">
        <property type="protein sequence ID" value="JAV67983.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01066300">
        <property type="protein sequence ID" value="JAV67986.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01066299">
        <property type="protein sequence ID" value="JAV67987.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1L8T1"/>
    <dbReference type="FunCoup" id="A0A1Y1L8T1">
        <property type="interactions" value="129"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1L8T1"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="PI-PLCXD1c"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PLCXD1/2/3"/>
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    <dbReference type="InterPro" id="IPR000909">
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    <dbReference type="PANTHER" id="PTHR13593">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593:SF113">
        <property type="entry name" value="SI:DKEY-266F7.9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
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    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="18"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="JAV67986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0793073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="324" mass="37351" checksum="825BA8494641C36C" modified="2017-08-30" version="1">MAKTNINLEYWMSNLPVHLRTWPLIRLAIPGSHDSMTASITKSSKIAPDAECLLQKLRFLGPLLRLIMSRWSKTQDLTIGDQLRCGIRYYDLRVATRRNKTYPYFVHGLYADEITTMVTSVREFIDSHPHEVVILDFQHFYAFAEEDHHNLITLLLTVFKSKLLPYTNDMNHITLEFMTESNKYQIILIYRANYSRLSQQYLWPSFTFPTPWPQTISQTDLFDKLNRGIATRLQSFAYVSQCVLTPTNGFVAKKLCSTLKKTCVVPIHGARIEWIQQQRIGEGGVNIVIGDFVNLNDFEFPAEVVQLNLQVFPTNASILTPVDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1L9C6</accession>
    <name>A0A1Y1L9C6_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_12905</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01063893">
        <property type="protein sequence ID" value="JAV68930.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1L9C6"/>
    <dbReference type="InParanoid" id="A0A1Y1L9C6"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.30">
        <property type="entry name" value="Haemolymph juvenile hormone binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010562">
        <property type="entry name" value="Haemolymph_juvenile_hormone-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038606">
        <property type="entry name" value="To_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008:SF32">
        <property type="entry name" value="CIRCADIAN CLOCK-CONTROLLED PROTEIN DAYWAKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008">
        <property type="entry name" value="PROTEIN TAKEOUT-LIKE PROTEIN"/>
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    </dbReference>
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        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00700">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036312536" evidence="1">
        <location>
            <begin position="18"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="JAV68930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0793285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="237" mass="26854" checksum="B413F539C1AAD466" modified="2017-08-30" version="1">MTGIYLLFFANILLVNAGINPKTRVYFKQCMEEDAVENNNACLLLNAQRVVALIPSDKPIEIKQWTIKGTKLLSYDQHYQNIKLYNHHQAKILKAGLEANEILETWKLVLEFHVPEVLFVSDYEFEPGSKLLNVDIASKGKVTYHHKDYNGTLTLSGGVTFDPDANFTATDSKVSLTMGGMSARFETGDSKLDERINTVYNANWPAIFEDATGEYTKVYAHVYKNIANDLIFDKEPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LBK0</accession>
    <name>A0A1Y1LBK0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Corticotropin-releasing factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_10559</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GEZM01065531">
        <property type="protein sequence ID" value="JAV68437.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1LBK0"/>
    <dbReference type="InParanoid" id="A0A1Y1LBK0"/>
    <dbReference type="OrthoDB" id="6418774at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005179">
        <property type="term" value="F:hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018446">
        <property type="entry name" value="Corticotropin-releasing_fac_CS"/>
    </dbReference>
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        <property type="entry name" value="CRF"/>
    </dbReference>
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        <property type="entry name" value="CRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00039">
        <property type="entry name" value="CRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00511">
        <property type="entry name" value="CRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0372">Hormone</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033289691" description="Corticotropin-releasing factor domain-containing protein" evidence="4">
        <location>
            <begin position="19"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Corticotropin-releasing factor" evidence="5">
        <location>
            <begin position="95"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="JAV68437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0796498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="153" mass="17506" checksum="D51AF38D29936248" modified="2017-08-30" version="1">MRVPVYFVCAALILYVKSEDRTNYDRRIEPLDLTADQETVSYLLPKLTAKYRPNTEWNGVKDPRFYVLTEAESNDIDFQEPLIGEGRIKRQGLNGGPSLSIVNSLDVLRNRLLLEIARKKQLEGMNRNRNLLSSVGKRAILGHRGLVPTFDNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LCH2</accession>
    <name>A0A1Y1LCH2_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein yellow</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_13881</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
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        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major royal jelly protein family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01061260">
        <property type="protein sequence ID" value="JAV70598.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0794261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1LCH2"/>
    <dbReference type="FunCoup" id="A0A1Y1LCH2">
        <property type="interactions" value="8"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1LCH2"/>
    <dbReference type="OrthoDB" id="7776143at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017996">
        <property type="entry name" value="MRJP/yellow-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10009">
        <property type="entry name" value="PROTEIN YELLOW-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10009:SF11">
        <property type="entry name" value="RH54244P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03022">
        <property type="entry name" value="MRJP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01366">
        <property type="entry name" value="ROYALJELLY"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036029805" description="Protein yellow" evidence="5">
        <location>
            <begin position="17"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="JAV70598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0794261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="408" mass="46274" checksum="4A8EB1640083393B" modified="2017-08-30" version="1">MWKLLIVTSVIAVSYAAKLQEVFRWRDVDFAWPSEQAKQEALQNQRYIPANNLPLGLARWKNKLFITIPRWKAGVASSLNYIPLNTSNSSPALIPYPSLKANTLPTNGEKLGDDRIVSTFRVEVDACDRLWVMDTGLADILGSGDQHSKPALVVFDLNTDRLLRRYEFKPEDLKDSSFFANVIVDVQPGRCDEAFAYVPDLGGYGIVVYSWKNNESWRIHHNYFHFDPLNGDLTVGGVNFQWTDGIFGLALGRMRSNGYRTLFFHPLVSTHEFSVSTEVLRNQTLAVDPNSYNLYKIEGNRGAATQASSSNLDLKTEVLFLTQLQKDGVACWNTNKPLNPENFGNVAQDKVGLVFPNDLKIDAERNLWVLSDRMPVFLFHSLNRNEYNYRIFRIKVDDAIVNTPCALN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LFC5</accession>
    <name>A0A1Y1LFC5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_06282</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="JAV72333.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
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        <property type="protein sequence ID" value="JAV72334.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KAB0800542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="9994780at2759"/>
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        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="arfaptin-2 isoform X1"/>
        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ARFAPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ARFAPTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Arfaptin"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
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        <location>
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            <end position="306"/>
        </location>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="1"/>
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        <location>
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        <source>
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            <dbReference type="ARBA" id="ARBA00023034"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="PROSITE" id="PS50870"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="JAV72334.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAB0800542.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="325" mass="36922" checksum="BF72FDECD5C6B1B9" modified="2017-08-30" version="1">MSQLKSSASERTSIHDMLKETPSNENRSSNVVAAVETKPACPYSRSVPTGLSACTSSPAILTPTAPTQNDDATIMKTSSRIENLKNWSISTYKCTKQLMFEKLGKSSRTVDTELEAQIEQLRETQRKYSNILRLSRALTSHFYHVVQTQHALGEAFSELAQKSPELQEEFLYNSETQRNLTKNGETLLGALNFFTSSVNTLCNKTIEDTLQSVRQYEAARIEYDAYRTDLESLMPKADGTVDFDEAQKSFEMHRQNFMKLRTEVTIKMKFLDENRIKVMHKQLLLFHNAISAYFSGNQVALEATLKQFNIKVKTPNSAFPSWLEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LFR7</accession>
    <name>A0A1Y1LFR7_PHOPY</name>
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        <recommendedName>
            <fullName evidence="5">Cytokine-like nuclear factor N-PAC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Glyoxylate reductase 1 homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Nuclear protein NP60 homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Putative oxidoreductase GLYR1 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PPYR_07714</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HIBADH-related family. NP60 subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="JAV72474.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1LFR7"/>
    <dbReference type="FunCoup" id="A0A1Y1LFR7">
        <property type="interactions" value="2080"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1LFR7"/>
    <dbReference type="OrthoDB" id="21615at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140673">
        <property type="term" value="P:transcription elongation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05836">
        <property type="entry name" value="PWWP_GLYR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000058">
        <property type="entry name" value="Putative oxidoreductase GLYR1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035501">
        <property type="entry name" value="GLYR1_PWWP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="HIBADH-like_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051265">
        <property type="entry name" value="HIBADH-related_NP60_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000313">
        <property type="entry name" value="PWWP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43580:SF2">
        <property type="entry name" value="CYTOKINE-LIKE NUCLEAR FACTOR N-PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43580">
        <property type="entry name" value="OXIDOREDUCTASE GLYR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00855">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00293">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50812">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PWWP" evidence="9">
        <location>
            <begin position="7"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="97"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="132"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00078412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00082969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="JAV72474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0799834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="506" mass="56211" checksum="CAD7F91FB4D18340" modified="2017-08-30" version="1">MSEKLQIGSLVWAKMKGFSPWPGLISKPKHWVKKPAKKTDFQCIYFFGTKNYAWIEESNIMPYLEFKEKLVNSCKSASFKEAVAEIEEFLERIEADPTFTPEQFDNEREQDTTFDRIKEDSKSAPKKKKESTGGTKRLSTAITPKASKKRKSSQSEENGAISPVLSNHVPKNYEELLNRPLVEKPASPSLDINSISESFKSKKIEASTKTFGFIGLGIMGSRIVKNLINSGHKVNLWNRTAKKAEEVKEQADLTSPGQVKTFSVPCDVVYNSDIIFSCVSDTRAAKNIVFTNCGVLYQQDGNSLEGKGYVELTSIDTETSKDISNVITSKGGRYLEAQLQGSKDEADNGSLIVLGAGDKSLFDDCQTCFQAMGKTAFYLGEVGYATKMNLILQVMRGISLAGLTEGLVLADRSGLSLKDVLEIFSITSMSSPALMEKANIIVNQDFRNPRMPLQHMQKDLKLALELSDSLQQPLLLTATANEVFKHARRLGYSKHDSAAVYMRARH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LI32</accession>
    <name>A0A1Y1LI32_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">V-type proton ATPase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_09241</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. May play a role in coupling of proton transport and ATP hydrolysis.</text>
    </comment>
    <comment type="function">
        <text evidence="7">Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits VhaAC45 and ATP6AP2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the V-ATPase V0D/AC39 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01056946">
        <property type="protein sequence ID" value="JAV72551.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1LI32"/>
    <dbReference type="FunCoup" id="A0A1Y1LI32">
        <property type="interactions" value="1857"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1LI32"/>
    <dbReference type="OrthoDB" id="10250083at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007430">
        <property type="term" value="P:terminal branching, open tracheal system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.50:FF:000002">
        <property type="entry name" value="V-type proton ATPase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1690.10:FF:000001">
        <property type="entry name" value="V-type proton ATPase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1690.10:FF:000002">
        <property type="entry name" value="V-type proton ATPase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.50">
        <property type="entry name" value="ATP synthase (C/AC39) subunit, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1690.10">
        <property type="entry name" value="V-type ATP synthase subunit C domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036079">
        <property type="entry name" value="ATPase_csu/dsu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002843">
        <property type="entry name" value="ATPase_V0-cplx_csu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016727">
        <property type="entry name" value="ATPase_V0-cplx_dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035067">
        <property type="entry name" value="V-type_ATPase_csu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044911">
        <property type="entry name" value="V-type_ATPase_csu/dsu_dom_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11028">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT AC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01992">
        <property type="entry name" value="vATP-synt_AC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018497">
        <property type="entry name" value="V-ATP_synth_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103486">
        <property type="entry name" value="V-type ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00046957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00056400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR018497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="JAV72551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0798248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="348" mass="39646" checksum="1DD8A6FAEDA3C0B1" modified="2017-08-30" version="1">MKGCIFNIDSGYLEGLCRGFKCGILKQSDYLNLVQCETLEDLKLHLQGTDYGTFLANEPSPLAVSTIDDKLREKLVIEFQHLRNHAVEPLSTFLDFITYSYMIDNIILLITGTLHQRPISELIPKCHPLGSFEQMEAIHVAATPAELYNAVLVDTPLAPFFVDCISEQDLDEMNIEIIRNTLYKAYLEAFFQFCKEIGGTTADCMCEILAFEADRRAIIITINSFGTELSKDDRAKLYPRCGKLNPDGLAALARAEDYDQVKAVAEYYAEYSKLFEGAGNNPGDKTLEDKFFEHEVKLNVMAFLQQFHFGVFYSYLKLKEQECRNIVWISECVAQKHRAKIDNYIPIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LJQ8</accession>
    <name>A0A1Y1LJQ8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">KIAA0930-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_07712</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01053932">
        <property type="protein sequence ID" value="JAV73904.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1LJQ8"/>
    <dbReference type="FunCoup" id="A0A1Y1LJQ8">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1LJQ8"/>
    <dbReference type="OrthoDB" id="1906921at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019141">
        <property type="entry name" value="DUF2045"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21477:SF13">
        <property type="entry name" value="KIAA0930"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21477">
        <property type="entry name" value="ZGC:172139"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09741">
        <property type="entry name" value="DUF2045"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="472"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="481"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="JAV73904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0799832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="679" mass="77841" checksum="08A0149BB14327B2" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LJX8</accession>
    <name>A0A1Y1LJX8_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_05444</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Recycling endosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GEZM01058110">
        <property type="protein sequence ID" value="JAV71896.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000003">
        <property type="protein sequence ID" value="KAB0801090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1LJX8"/>
    <dbReference type="FunCoup" id="A0A1Y1LJX8">
        <property type="interactions" value="1096"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1LJX8"/>
    <dbReference type="OrthoDB" id="8956628at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045055">
        <property type="term" value="P:regulated exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000151">
        <property type="entry name" value="Rab11 family-interacting protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037245">
        <property type="entry name" value="FIP-RBD_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037789">
        <property type="entry name" value="FIP_classI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019018">
        <property type="entry name" value="Rab-bd_FIP-RBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15746:SF23">
        <property type="entry name" value="RAB11 INTERACTING PROTEIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15746">
        <property type="entry name" value="RAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09457">
        <property type="entry name" value="RBD-FIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144270">
        <property type="entry name" value="Eferin C-derminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51511">
        <property type="entry name" value="FIP_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="C2" evidence="6">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="FIP-RBD" evidence="7">
        <location>
            <begin position="415"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="JAV71896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0801090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="489" mass="54935" checksum="38D1ABF5B119237D" modified="2017-08-30" version="1">MWMPTHVQVTVQRAADLLTKGKNNTNDCFVTIALGKTKYQTSVKEKAEPSVEWHEECELLIPDQGNTAVIILTVLHRNFLGVDEFLGRVEIPLNQLDVYERPKNRWYTLQSKPGKEGKHKERGKLEVKTAFIVKSGSLTDLTKKDKHKSSIGHLSHLAQSVGGSLLSISSIDKRKGIKKIAKSLGSKMHLKGKKKDVDLDDASSIGSIGSLQRRNDNLNINYKTKQTREDADPGVVSEDEDDFTFDDLSHKSSGSSLNHMVTQTGIVTSTSVTSLENVAPVEAARKNSAGHVAPVKPPRAEQKGQDEWELKLYGKQSKNLLKPNSTESLNKKPWESPKLEAQIEEDEVIEFRVPVTKEDDSFNYANSPVLPKKEEKESMLSKLKKIRKDKLEKFHLNSQERIIIGGETEVKVTGNNKASNEILQKFDGKSREDLILLVCDMQGELEHSRKKMSDLEDYLDELLLRVMETTPRILQIPYVGCKMGNTKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LP59</accession>
    <name>A0A1Y1LP59_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">V-type proton ATPase 16 kDa proteolipid subunit c</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">V-type proton ATPase 21 kDa proteolipid subunit c''</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Vacuolar proton pump 16 kDa proteolipid subunit c</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PPYR_05853</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">1611_PpyrPB1</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">1611_PpyrPB1</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the V-ATPase proteolipid subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01051750">
        <property type="protein sequence ID" value="JAV74721.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000003">
        <property type="protein sequence ID" value="KAB0801499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1LP59"/>
    <dbReference type="InParanoid" id="A0A1Y1LP59"/>
    <dbReference type="OrthoDB" id="10264021at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18177">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6F_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18178">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6F_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.610:FF:000002">
        <property type="entry name" value="V-type proton ATPase proteolipid subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.610">
        <property type="entry name" value="lithium bound rotor ring of v- atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000245">
        <property type="entry name" value="ATPase_proteolipid_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10263">
        <property type="entry name" value="V-TYPE PROTON ATPASE PROTEOLIPID SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00122">
        <property type="entry name" value="VACATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="89"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="133"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="173"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="13">
        <location>
            <begin position="50"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="13">
        <location>
            <begin position="139"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00071448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="JAV74721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAB0801499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="208" mass="21869" checksum="2D0AA6C0E475272D" modified="2017-08-30" version="1">MRYYLSYLFSLAVSLFVIFVALYYLFTGKGTEISLGWFLESTSPYMWASLGIGFSVSLSVVGAAVGIYTTGVSILGGGVKAPRIKTKNLISIIFCEAVAIYGLIMAIVLSGIITDYSSSKFEFNDDLRAKNYMGGYVIFGAGLSVGLVNLFCGLAVGIVGSGAALADAANAALFVKVLIIEIFGSAIGLFGLIVGVYMNSRASMGDSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LX45</accession>
    <name>A0A1Y1LX45_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">S-phase kinase-associated protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_04883</name>
        <name evidence="8" type="ORF">PPYR_12818</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the SKP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01048052">
        <property type="protein sequence ID" value="JAV76645.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1LX45"/>
    <dbReference type="FunCoup" id="A0A1Y1LX45">
        <property type="interactions" value="1880"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1LX45"/>
    <dbReference type="OrthoDB" id="2342932at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18322">
        <property type="entry name" value="BTB_POZ_SKP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000018">
        <property type="entry name" value="S-phase kinase-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016897">
        <property type="entry name" value="SKP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001232">
        <property type="entry name" value="SKP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036296">
        <property type="entry name" value="SKP1-like_dim_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016072">
        <property type="entry name" value="Skp1_comp_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016073">
        <property type="entry name" value="Skp1_comp_POZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11165">
        <property type="entry name" value="SKP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01466">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03931">
        <property type="entry name" value="Skp1_POZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028729">
        <property type="entry name" value="E3_ubiquit_lig_SCF_Skp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00512">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81382">
        <property type="entry name" value="Skp1 dimerisation domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="SKP1 component POZ" evidence="6">
        <location>
            <begin position="3"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="SKP1 component dimerisation" evidence="5">
        <location>
            <begin position="112"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR028729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="JAV76645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0793198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0802697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="162" mass="18525" checksum="3561C7CC2A04DC79" modified="2017-08-30" version="1">MPNIKLQSSDGETFEIDVEIAKCSVTIKTMLEDLGMDDDEEEIVPLPNVNSAILKKVIQWATYHKDDPPPPEDDENKEKRTDDISSWDADFLKVDQGTLFELILAANYLDIKGLLDVTCKTVANMIKGKTPEEIRKTFNIKNDFTASEEEQVRKENEWCEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1M3Z5</accession>
    <name>A0A1Y1M3Z5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Ras-related protein Rab-2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PPYR_01932</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">1611_PpyrPB1</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">1611_PpyrPB1</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Endomembrane system</location>
            <topology evidence="12">Lipid-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01042610">
        <property type="protein sequence ID" value="JAV79758.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01042609">
        <property type="protein sequence ID" value="JAV79759.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1M3Z5"/>
    <dbReference type="FunCoup" id="A0A1Y1M3Z5">
        <property type="interactions" value="1517"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1M3Z5"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01866">
        <property type="entry name" value="Rab2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000275">
        <property type="entry name" value="Putative ras-related protein Rab-2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0636">Prenylation</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="188"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="200"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="JAV79758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAB0804962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="213" mass="23603" checksum="74135C6AD3DCCC6A" modified="2017-08-30" version="1">MSYAYLFKYIIIGDTGVGKSCLLLQFTDKRFQPVHDLTIGVEFGARMITIDGKQIKLQIWDTAGQEAFRSITRSYYRGAAGALLVYDITRRETFNHLTTWLEDARQHSNSNMVIMLIGNKSDLESRREVKKEEGEAFAREHGLVFMETSAKTAANVEEAFINTAREIYEKIQEGVFDINNEANGIKIGPQHSPTNPSLPGTGGQGGSQGGGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1M7T1</accession>
    <name>A0A1Y1M7T1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zinc finger CCCH domain-containing protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
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                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
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                <person name="Shigenobu S."/>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
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                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
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        <source>
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    <sequence length="124" mass="14250" checksum="C7975963095450A6" modified="2017-08-30" version="1">MSNPTEEQLFKAVKESLEKDGRLGRFKAQLCSSVMSILHTRQPTKEDFGEIPEETKIINELLREYLLWNGYVYSENFLSVESGADKDKQPKEKVAAKLGIIDVPRKSEIPLLYYIVSAFQNHDE</sequence>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
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                <person name="Bessho-Uehara M."/>
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                <person name="Schmitz R.J."/>
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            <strain evidence="3">1611_PpyrPB1</strain>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
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                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
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            <dbReference type="PubMed" id="30324905"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 5">
            <text>N-terminal glycyl-[protein] + tetradecanoyl-CoA = N-tetradecanoylglycyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15521"/>
            <dbReference type="Rhea" id="RHEA-COMP:12666"/>
            <dbReference type="Rhea" id="RHEA-COMP:12667"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57385"/>
            <dbReference type="ChEBI" id="CHEBI:64723"/>
            <dbReference type="ChEBI" id="CHEBI:133050"/>
            <dbReference type="EC" id="2.3.1.97"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the NMT family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.97" evidence="2 5"/>
    <dbReference type="EMBL" id="GEZM01013523">
        <property type="protein sequence ID" value="JAV92511.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1N3L6"/>
    <dbReference type="FunCoup" id="A0A1Y1N3L6">
        <property type="interactions" value="2161"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1N3L6"/>
    <dbReference type="OrthoDB" id="60315at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004379">
        <property type="term" value="F:glycylpeptide N-tetradecanoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.170:FF:000001">
        <property type="entry name" value="Glycylpeptide N-tetradecanoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000042">
        <property type="entry name" value="Glycylpeptide N-tetradecanoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000903">
        <property type="entry name" value="NMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022677">
        <property type="entry name" value="NMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022678">
        <property type="entry name" value="NMT_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022676">
        <property type="entry name" value="NMT_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11377:SF5">
        <property type="entry name" value="GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11377">
        <property type="entry name" value="N-MYRISTOYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01233">
        <property type="entry name" value="NMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02799">
        <property type="entry name" value="NMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015892">
        <property type="entry name" value="N-myristl_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00975">
        <property type="entry name" value="NMT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00976">
        <property type="entry name" value="NMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycylpeptide N-tetradecanoyltransferase N-terminal" evidence="8">
        <location>
            <begin position="116"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Glycylpeptide N-tetradecanoyltransferase C-terminal" evidence="9">
        <location>
            <begin position="288"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="JAV92511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0798108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="475" mass="54785" checksum="ED8537713AD7A570" modified="2017-08-30" version="1">MSGKNDLSNKSQKNGNLDSNIQSKGVKKRHKGKKANAENREEKEEITPVEEFVSGTDLNRLGNMMTIKDLRAAVEAFSLQEKPAKTQEEALHKSYQFWSTQPVPKMDEKITANEAIEADKEVAEIRNEPYTLPDGFQWDTLNLDEPLVLKELYTLLNENYVEDDDCMFRFDYQPDFLKWALQPPGWRKDWHCGVRVIKSGRLVGFISAIPATLNIYDKQQRMVEINFLCVHKKLRSKRVAPVLIREITRRVHLTGIFQAVYTAGVVLPKPIGTCRYWHRSLNPKKLIDVKFSHLSRNMTMQRTLKLYKLPDQPKTPGFRKMTLGDVPKTHKVLQDYLKRFDLAPHFSQEDFVHWFLPQAGIVDSFIVENGGVVTDFVSYYTLPSTVMHHPVHKTLKAAYSFYNVSAKTPWVDLMNDGLISAKQLEFDVFNALDLMDNKEFLETLKFGIGDGNLQYYLYNWKCPSMQANKIGLVLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1N5X0</accession>
    <name>A0A1Y1N5X0_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_13702</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01016967">
        <property type="protein sequence ID" value="JAV91003.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01016963">
        <property type="protein sequence ID" value="JAV91007.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0794082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1N5X0"/>
    <dbReference type="InParanoid" id="A0A1Y1N5X0"/>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007188">
        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007266">
        <property type="term" value="P:Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000563">
        <property type="entry name" value="Guanine nucleotide-binding protein alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.400.10:FF:000007">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000692">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000469">
        <property type="entry name" value="Gprotein_alpha_12/13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF231">
        <property type="entry name" value="GUANINE NUCLEOTIDE BINDING PROTEIN (G PROTEIN) ALPHA V1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00440">
        <property type="entry name" value="GPROTEINA12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="45"/>
            <end position="50"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="153"/>
            <end position="154"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="178"/>
            <end position="184"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="203"/>
            <end position="207"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="272"/>
            <end position="275"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="331"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="JAV91007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0794082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="359" mass="41146" checksum="7F80DF87E12256DA" modified="2017-08-30" version="1">MGACLSIEREEGKARRRSEEIDRQLGELAKQQNHVIKILLLGAGESGKSTLVKQMKIIHADGFTSTELCSFRPTVLDNLLASMKYVLAGMGLLRINLEYSRNKTHAQVVLQSRSCFDMTFTVLPNVAASLQVLWSDRGVRLAVARGYEYELNDSALYLFENMDRICDAKYVPSPTDVLRARVRTQGIIETHFRINDMVVSMYDVGGQRSQRRKWIYCFDDVRAVLFVVSLSGYDMTLLEDPSVNRLDESLNLFGQIVNNPFFRDASFVLLLNKFDLFREKILYSQRHLRLYFPDYKGPDKDVDRGALFIQHKFVLRNKDSRKVLYPHFTTATDTANVQVVFQSIMEMVISENLGQVTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1N6I1</accession>
    <name>A0A1Y1N6I1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_06362</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Elbow/Noc family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01011895">
        <property type="protein sequence ID" value="JAV93349.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000004">
        <property type="protein sequence ID" value="KAB0800622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1N6I1"/>
    <dbReference type="FunCoup" id="A0A1Y1N6I1">
        <property type="interactions" value="302"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1N6I1"/>
    <dbReference type="OrthoDB" id="10054079at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051520">
        <property type="entry name" value="Elbow/Noc_ZnFinger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12522:SF4">
        <property type="entry name" value="ZINC FINGER PROTEIN ELBOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12522">
        <property type="entry name" value="ZINC-FINGER PROTEIN NOLZ1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="328"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="41"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="53"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="70"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="89"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="110"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="158"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="JAV93349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0800622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="452" mass="47456" checksum="761F52AD601A2855" modified="2017-08-30" version="1">MLTSGNQYLRPEYLTPLPTTLDAKKSPLALLAQTCSQIGADLPNSKLIQSAEKGNKSSKSDSIKSKSPSAINCNESHNKSSFKPYDASLPRDKTQSPEDRSSANRVRTPAKSTITNSRCSSNQSEASPGPSPAASDRKTPIVDPNELERTSPTKSRDSISSPTPASSNGKTASTPSILTSTTDPSIKDLPLGTFKPGAMPPTSTFLGGYPTPGIPLPMDLMASSLLSHHQSLKSGAFGPYSSYVRMKGALGSESLAPACRDPYCTGCSLSSHLLASSGVGGKSNCPAGCTQCDHVASKTAGYLGHNPLAAAYAHAQLAALAAASQLPYVCNWIAGDATYCGKRFSTSEELLQHLRSHTAIVSAAETNPTLSMLNTTSLPPTHPLLHRTYPTPPLSPLATARYHPYSKPSLLPPSFTSSTLSSFPLGHPGLPAYLSPYSLYGPRLSTSSGMHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N3ZYG5</accession>
    <name>A0A5N3ZYG5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_15580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01001918">
        <property type="protein sequence ID" value="KAB0790103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N3ZYG5"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01644">
        <property type="entry name" value="RT_pepA17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040676">
        <property type="entry name" value="DUF5641"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008042">
        <property type="entry name" value="Retrotrans_Pao"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF1">
        <property type="entry name" value="GAG-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18701">
        <property type="entry name" value="DUF5641"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05380">
        <property type="entry name" value="Peptidase_A17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="1417"/>
            <end position="1609"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0790103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1738" mass="198329" checksum="EFD2840A6AAE9497" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N3ZYP2</accession>
    <name>A0A5N3ZYP2_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Peptidoglycan recognition protein family domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_15490</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Peptidoglycan-recognition protein probably involved in innate immunity by binding to peptidoglycans (PGN) of bacteria and activating the prophenoloxidase (proPO) cascade immune response. Binds to 1,3-beta-D-glucan and PGN.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01001726">
        <property type="protein sequence ID" value="KAB0790180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N3ZYP2"/>
    <dbReference type="FunCoup" id="A0A5N3ZYP2">
        <property type="interactions" value="56"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N3ZYP2"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06583">
        <property type="entry name" value="PGRP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.80.10:FF:000001">
        <property type="entry name" value="Peptidoglycan recognition protein 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.80.10">
        <property type="entry name" value="Peptidoglycan recognition protein-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036505">
        <property type="entry name" value="Amidase/PGRP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002502">
        <property type="entry name" value="Amidase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015510">
        <property type="entry name" value="PGRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006619">
        <property type="entry name" value="PGRP_domain_met/bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11022">
        <property type="entry name" value="PEPTIDOGLYCAN RECOGNITION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11022:SF41">
        <property type="entry name" value="PEPTIDOGLYCAN-RECOGNITION PROTEIN LC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01510">
        <property type="entry name" value="Amidase_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00644">
        <property type="entry name" value="Ami_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00701">
        <property type="entry name" value="PGRP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55846">
        <property type="entry name" value="N-acetylmuramoyl-L-alanine amidase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0391">Immunity</keyword>
    <keyword evidence="2" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidoglycan recognition protein family" evidence="8">
        <location>
            <begin position="209"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetylmuramoyl-L-alanine amidase" evidence="7">
        <location>
            <begin position="221"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidoglycan recognition protein family" evidence="8">
        <location>
            <begin position="385"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetylmuramoyl-L-alanine amidase" evidence="7">
        <location>
            <begin position="397"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="174"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00057187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0790180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="558" mass="62046" checksum="C4C17F056AF2B5BD" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N3ZYZ7</accession>
    <name>A0A5N3ZYZ7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA-directed DNA polymerase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_15393</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01001577">
        <property type="protein sequence ID" value="KAB0790269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N3ZYZ7"/>
    <dbReference type="InParanoid" id="A0A5N3ZYZ7"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0790269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="200" mass="23642" checksum="33200059D1CC5FF6" modified="2020-02-26" version="1" fragment="single">ININPEKTQQIIFSKKYTYNKIYSPLKVQNHIITPTNTVKYLGMYLDTRLNHRAHTTKTLQKAYATMRLAYPIMKNPATSEENKKLVYTPIIRPIITYAAPVWCNASNPTLQKLQIFQNKCLRLIANADRYTRIEYLHERTGIETIKEYINRISQHFYKTQLKHNPLTNTITMLRAHNTVKEPKHKLTYQHLPIFNEIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N3ZZU0</accession>
    <name>A0A5N3ZZU0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_15006</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01001082">
        <property type="protein sequence ID" value="KAB0790587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N3ZZU0"/>
    <dbReference type="InParanoid" id="A0A5N3ZZU0"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0790587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="108" mass="11955" checksum="131D295DA1E8AD63" modified="2020-02-26" version="1">MEFYEIARFPGVTGCIDGTHIPIRSPGGDRAEVFRNRKGYFSINCQATGNLSGLLLGDSAHAQSRFMFTPVPEPNNIADQAYNAAQVRTRNVVERTFGQWNNASVAYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A014</accession>
    <name>A0A5N4A014_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_14891</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000938">
        <property type="protein sequence ID" value="KAB0790665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A014"/>
    <dbReference type="InParanoid" id="A0A5N4A014"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0790665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="191" mass="21534" checksum="536677AD21B6663D" modified="2020-02-26" version="1">MSKELTDKCLLSISTRQINRIISNLKKHDTSNSERINVDKQVDINPAGSSNDEPDEPFNNEIPFDTRSECFIESGNDETTFPSECKNDDLDDDVNALNDSFNMADVLSDSLQRTPSFANDLRLWAIKNKIPHSALSELMKILLKHNIKSDELPSDSRTLLKTPRSTVIRPVKPGNYLHFGVLPNLRAIKNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A0T3</accession>
    <name>A0A5N4A0T3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">V-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_02716</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0790916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A0T3"/>
    <dbReference type="FunCoup" id="A0A5N4A0T3">
        <property type="interactions" value="414"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A0T3"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15870">
        <property type="entry name" value="R-SNARE_VAMP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016444">
        <property type="entry name" value="Synaptobrevin/VAMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45701">
        <property type="entry name" value="SYNAPTOBREVIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="3">
        <location>
            <begin position="7"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0790916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="107" mass="12219" checksum="10BD89E8DAA3BA9E" modified="2020-02-26" version="1">MPGKKTVLEQTQDQVNEVVGIMRVNVEKVLERDQKLSELDSRADALQEGGKRFEQQAQRLHKKYWWKNMKMMIILGVIGVAILIIIIVSLTGKSDDSPKTEKPSEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A378</accession>
    <name>A0A5N4A378_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Kringle domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PPYR_03567</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A378"/>
    <dbReference type="InParanoid" id="A0A5N4A378"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2000.10">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.20.10">
        <property type="entry name" value="Plasminogen Kringle 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020067">
        <property type="entry name" value="Frizzled_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036790">
        <property type="entry name" value="Frizzled_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000001">
        <property type="entry name" value="Kringle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013806">
        <property type="entry name" value="Kringle-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038178">
        <property type="entry name" value="Kringle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050759">
        <property type="entry name" value="Serine_protease_kringle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24261:SF7">
        <property type="entry name" value="KRINGLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24261">
        <property type="entry name" value="PLASMINOGEN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00051">
        <property type="entry name" value="Kringle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00018">
        <property type="entry name" value="KRINGLE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00130">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57440">
        <property type="entry name" value="Kringle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50038">
        <property type="entry name" value="FZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50070">
        <property type="entry name" value="KRINGLE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 7" id="KW-0420">Kringle</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="266"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="FZ" evidence="10">
        <location>
            <begin position="15"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Kringle" evidence="11">
        <location>
            <begin position="190"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="327"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="390"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="437"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="329"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="437"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="455"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="465"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAB0791767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="508" mass="57591" checksum="CE521F5373E7F966" modified="2020-02-26" version="1">MEDLSQIANTSDYDVTQPFCQTYQGTTCREYLDGKLIFVQPPYTQENIEIKLEQAVLVVSQSNEISTSCSKFAIPSLCFSAFPICIDPKHVAHYQKDFTKKYLAEQDKSIFKNLRNKLSMSLQRICKEECELLEKELCRREYAIAKRHPIISQPLELDECEFLPDESDKNSMYCLSLGVERTQNVNEDELCYWDYGESYRGVYDATISNKKCIRWSHQFTIALSEYPELSGHSYCRNPGRTEAEPFCFVDQTRKEVCGLPKCASMLWMYLIVGGLIVLIIAVVIILSIYCHRARKRRKTRLQNVSMAPCRCDFDRSSQMSVPTADKNIYGNTGPNSPMELNTLLPTRINNMPPRSQSSQRNGFQPAPQYTYKEGDLHEFLIANSPNEGKSSYCKPAEAHPRHSSKSSHASDSPTVCASSADPPHIWDLKKVSSNKLNESQSSLTSHSSSLGNSNKTQSTSLSNENSKRKSIDRRSNKNIRPENVPEGYAPKNIVVNSNGDTFETKLTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A408</accession>
    <name>A0A5N4A408_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_14026</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A408"/>
    <dbReference type="FunCoup" id="A0A5N4A408">
        <property type="interactions" value="1718"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A408"/>
    <dbReference type="OrthoDB" id="445357at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000380">
        <property type="term" value="P:alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12381:SF56">
        <property type="entry name" value="B30.2_SPRY DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12381">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN U FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13671">
        <property type="entry name" value="AAA_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAP" evidence="2">
        <location>
            <begin position="6"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="854"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1022"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="467"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="477"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="854"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="892"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="915"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="939"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="953"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1030"/>
            <end position="1045"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0792065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1076" mass="121258" checksum="2C61E120E6B24068" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A430</accession>
    <name>A0A5N4A430_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">G-protein coupled receptors family 2 profile 2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PPYR_14013</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 2 family. Mth subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A430"/>
    <dbReference type="FunCoup" id="A0A5N4A430">
        <property type="interactions" value="151"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A430"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15039">
        <property type="entry name" value="7tmB3_Methuselah-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.180.11">
        <property type="entry name" value="Methuselah ectodomain, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023311">
        <property type="entry name" value="Methusela_ecto_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036272">
        <property type="entry name" value="Methuselah_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051384">
        <property type="entry name" value="Mth_GPCR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47154">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR MTH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47154:SF2">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR MTH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63877">
        <property type="entry name" value="Methuselah ectodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024274330" description="G-protein coupled receptors family 2 profile 2 domain-containing protein" evidence="11">
        <location>
            <begin position="21"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="154"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="257"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="308"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="358"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="391"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="12">
        <location>
            <begin position="146"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAB0792052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="444" mass="50953" checksum="BCE755CED2FAAECA" modified="2020-02-26" version="1">MGGLNCAALLIFVLKTAVFCEKSVVSYSVQDKIYNSSTQCAQNLTCIRKCCDVDYVMREKTCILRNDTDLNIPVYEATEVTGQVIVEYLVGFINCDHGFYKLEPNVYEDDAYYLQTNGSLWMPNTGEWLGFEEFCLENMGGNEISALLCFSERMMISLPFLFATFLVYAVLPDLTLHAKCLMCYVITLGLGYASLLFIQFNSSLIEDASCATIGISCYYFLMTSFFWMNAIAIDIWWTFSGLRRLSGSRKESERKHFFLYCGYACGASFLLISIVVGLTVGDVDQKAWYYPGFGKNQCWFKGEMAQCLYIYVPLAAIIIANVVLFAVTAFKIKRVQRDTAVLRKEDKSYENDKQKFHLFLKLMLAMGVNWTTEFVSWLVNWQVAHVPPSVWYLTDFCNAVYGVLIFFLFVFKRNVWKQLKRRYYMIIGKPHLARSDTETSTTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A4I9</accession>
    <name>A0A5N4A4I9_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_14192</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A4I9"/>
    <dbReference type="InParanoid" id="A0A5N4A4I9"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000095">
        <property type="entry name" value="Ankyrin 2, isoform J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000003">
        <property type="entry name" value="Ankyrin, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000001">
        <property type="entry name" value="Ankyrin-2 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="24"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="21"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="21"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="110"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="143"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="176"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="271"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="304"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="337"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="370"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="403"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="436"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="469"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="502"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="535"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="568"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="601"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="634"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="667"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="700"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="733"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="766"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="799"/>
            <end position="831"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0792233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="898" mass="96061" checksum="FE515F47BDEE4E2A" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A4R2</accession>
    <name>A0A5N4A4R2_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phorbol-ester/DAG-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_14269</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the DEF8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A4R2"/>
    <dbReference type="FunCoup" id="A0A5N4A4R2">
        <property type="interactions" value="16"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A4R2"/>
    <dbReference type="OrthoDB" id="1918044at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20819">
        <property type="entry name" value="C1_DEF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051366">
        <property type="entry name" value="DEF8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047983">
        <property type="entry name" value="DEF8_C1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025258">
        <property type="entry name" value="RH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12326:SF3">
        <property type="entry name" value="DIFFERENTIALLY EXPRESSED IN FDCP 8 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12326">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13901">
        <property type="entry name" value="RH_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01175">
        <property type="entry name" value="DUF4206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="6">
        <location>
            <begin position="114"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0792310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="426" mass="48072" checksum="E39A5065B5626803" modified="2020-02-26" version="1">MTNTERAASVSSPSSNTSGALSIDFDDHLLPSSLAAEELQLALNKEAGEVELQTAIDRCKELVLECDQCSSERKWLVRHLIELRLRLQECQDALSDPLHPRNSSSGASTRTVRGHHLHLQPLLSTSSHYCDHCTGTIWSVVQAWYQCRDCGYNCHHKCISFIVRECAHVTITERGGYEPDICPEIGLSRQKFQCAECQVALPIDTLWSEARKCDYSGLYYCSACHWGSSAVIPARVVHNWDFVPQYVCQASLQLLRISAHLPLINLEKLNPSIFSVVHELKLVRRLRNELNGMRKYLLVCRDAEGSRFIWKNVDRPHIIESPDLYSLQDLVDTQSGELPSKLHSLSHTFSEHIKTKCEVCKGRGHICEVCSNDEVLYPFDVDASICKACGVVLHKSCSARRKKCPKCLRLEQRKQELADVTDGDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A6A5</accession>
    <name>A0A5N4A6A5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PPYR_14823</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A6A5"/>
    <dbReference type="InParanoid" id="A0A5N4A6A5"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17318">
        <property type="entry name" value="MFS_SLC17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000003">
        <property type="entry name" value="Solute carrier family 17 member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050382">
        <property type="entry name" value="MFS_Na/Anion_cotransporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662:SF336">
        <property type="entry name" value="LP19554P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0769">Symport</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024322966" description="Major facilitator superfamily (MFS) profile domain-containing protein" evidence="8">
        <location>
            <begin position="19"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="162"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="249"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="293"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="337"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="385"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="423"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="2"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0792864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="482" mass="52447" checksum="2A633CB78D7DE482" modified="2020-02-26" version="1">MAIFMVCFFNYMLRVNMSINLIAMVQPITNNNKTHIAECLIINGKMNQSDDFSQLSVVPDYGVRYTWTSKQQGLILAAYFWGSILTSIPGGYLAERFGPTKTIAISNIVSALVTFLTPFVADWSWIAVIAFRFILGLMAGVCYPALHCMVSRWVPPDEKGKFGGALLGGTIGTVVTWPLSGSIIEHLGWSWAFYIQGGLVLAFSCVWLIAVADSPDTHPRISKEEKFYINKCLGEGVGKVKATPPYLKIFASIPFWALAILHFGNLWGLYLLLTAGPKYMSEVLGFNLGHSGLLAALPYLARAISGFVFGFVGDVLRKHQCLSVTTIRKLFVTTSHFLPGVLLLTILCAGCNITLCIALITLSLGFNGSSSITNIQNNQDLSPNFAGTIYGIINCIGGTTGFFTPMITGYLTADHNGLKEWHIIFAIGASVYISTGIVFCIFGSGDQQPWNQIDTKQVEGVDNAAFDGGASKETQTTENTKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A7A4</accession>
    <name>A0A5N4A7A4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Centrosomal protein of 162 kDa</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PPYR_12805</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
            <location evidence="1">Centriole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CEP162 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A7A4"/>
    <dbReference type="FunCoup" id="A0A5N4A7A4">
        <property type="interactions" value="14"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A7A4"/>
    <dbReference type="OrthoDB" id="2157184at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005879">
        <property type="term" value="C:axonemal microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038774">
        <property type="entry name" value="CEP162-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34031">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 162 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34031:SF1">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 162 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="7 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="26"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="106"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="477"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="205"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="398"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="515"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="643"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="131"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0793185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="762" mass="87814" checksum="F60F5EA40CA3F62D" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A7N6</accession>
    <name>A0A5N4A7N6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Actin-interacting protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_12953</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat AIP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A7N6"/>
    <dbReference type="FunCoup" id="A0A5N4A7N6">
        <property type="interactions" value="1453"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A7N6"/>
    <dbReference type="OrthoDB" id="2306at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030042">
        <property type="term" value="P:actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040011">
        <property type="term" value="P:locomotion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030834">
        <property type="term" value="P:regulation of actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045214">
        <property type="term" value="P:sarcomere organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000167">
        <property type="entry name" value="Actin-interacting protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000097">
        <property type="entry name" value="WD repeat domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19856:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19856">
        <property type="entry name" value="WD-REPEATCONTAINING PROTEIN WDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="54"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="185"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="229"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="315"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="522"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00067845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0793333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="601" mass="65730" checksum="A308CC5F14F60555" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A7Z7</accession>
    <name>A0A5N4A7Z7_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_13076</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A7Z7"/>
    <dbReference type="InParanoid" id="A0A5N4A7Z7"/>
    <dbReference type="OrthoDB" id="8194670at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.20">
        <property type="entry name" value="Pheromone/general odorant binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036728">
        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024367610" evidence="1">
        <location>
            <begin position="18"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0793456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="123" mass="13732" checksum="F8DA55E1C94DE1E5" modified="2020-02-26" version="1">MKIFIAVVACILAVTLAQDDELEKLVNDCAETAGLGDLEGYRKAAEENGINDEKVQKFSECVLRTRDEIKDDGTLDFSKYRAWCQVTGKDCSFVDECEKKKEDTTGKTYANVLLCGLKHSLKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A845</accession>
    <name>A0A5N4A845_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_13126</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A845"/>
    <dbReference type="InParanoid" id="A0A5N4A845"/>
    <dbReference type="OrthoDB" id="6738770at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23992">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.20">
        <property type="entry name" value="Pheromone/general odorant binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006170">
        <property type="entry name" value="PBP/GOBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036728">
        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01395">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024415265" evidence="1">
        <location>
            <begin position="20"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0793506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="137" mass="15371" checksum="ECCE14D15488536E" modified="2020-02-26" version="1">MNTLLMPVIVSLSVFLSSAYDQSGLEGRDYECMKELNLTVDFVVNGFDEYNFLREGDPELNAFLNCTWRKAGYLTTEGQINPDGLKAWLEVDLIQKKPGIKTTAEDLVRPCQSIRGDDPGDTGIKVYNCIVRTLWGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A8D0</accession>
    <name>A0A5N4A8D0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Endonuclease III homolog</fullName>
            <ecNumber evidence="13">3.2.2.-</ecNumber>
            <ecNumber evidence="13">4.2.99.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Bifunctional DNA N-glycosylase/DNA-(apurinic or apyrimidinic site) lyase</fullName>
            <shortName evidence="13">DNA glycosylase/AP lyase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">NTH1</name>
        <name evidence="16" type="ORF">PPYR_13169</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">1611_PpyrPB1</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 13">Belongs to the Nth/MutY family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.-" evidence="13"/>
    <dbReference type="EC" id="4.2.99.18" evidence="13"/>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A8D0"/>
    <dbReference type="FunCoup" id="A0A5N4A8D0">
        <property type="interactions" value="1085"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A8D0"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000703">
        <property type="term" value="F:oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1670.10:FF:000003">
        <property type="entry name" value="Endonuclease III homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.30:FF:000005">
        <property type="entry name" value="Endonuclease III-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="entry name" value="Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03183">
        <property type="entry name" value="Endonuclease_III_Nth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004036">
        <property type="entry name" value="Endonuclease-III-like_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000445">
        <property type="entry name" value="HhH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030841">
        <property type="entry name" value="NTH1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43286">
        <property type="entry name" value="ENDONUCLEASE III-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43286:SF1">
        <property type="entry name" value="ENDONUCLEASE III-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00633">
        <property type="entry name" value="HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01155">
        <property type="entry name" value="ENDONUCLEASE_III_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 13" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9 13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="10 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="HhH-GPD" evidence="15">
        <location>
            <begin position="124"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAB0793549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="305" mass="34610" checksum="4FC6560E6B473F1C" modified="2020-02-26" version="1">MKRITRNSTKENPGRATTSSEAVETGTKPNLSQFKLEPKRNLHSKRTHVPVEYEEPTNPKKPSKLIEKTFASSAPKDWEKAFRNLREMRKDYDAPVDTMGCDRCAEDGAPPEDQRLQSLISLMLSSQTKDQINHATMLKLREYGCNLTGMLEISEEKLGEIIRPVNFWKTKTKNIKRAVEMIRDEFNSDIPKTVEGLCRLPGVGPKMAHLCMKTAWGEISGIGVDTHVHRITNRLGWVKTKTPEDTRKALEAWLPRELWNDINLLMVGFGQQLCQPVKPQCHNCLNSDLCPTGMKELKSQKGKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A8J0</accession>
    <name>A0A5N4A8J0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_13254</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A8J0"/>
    <dbReference type="InParanoid" id="A0A5N4A8J0"/>
    <dbReference type="OrthoDB" id="8120565at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050549">
        <property type="entry name" value="MFS_Trehalose_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021:SF46">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="259"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="14"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0793634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="300" mass="33018" checksum="8BCF06C69B353E10" modified="2020-02-26" version="1">MRGLREILQNCRYMQYLAAMSAAMAAICSFMIGSWGSPSIPKLTSADSPLGVALNSEEVSWVASSHLLGYTVGSLVSPIPLKMIGPKWSLLITSLPLAGCWFGIAFSKSPIGLILLRFLSGVCDGVILTVLPLYIGEVADKDIRGKLISFSPIFAGLGNFIVLAVGPFVEYKTLTFICAAVPIIFGSVFVFLPESPYFLLKTGRTEESKCSLRTLSGSSVDEPTIDERMNEIEATVRVHCEASQRCNVLYIFSKRHFRFALFISLHLRLINVFGGMSVIKPYLQTKLEQQEAVFLPKFRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A8J2</accession>
    <name>A0A5N4A8J2_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PPYR_13260</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A8J2"/>
    <dbReference type="InParanoid" id="A0A5N4A8J2"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000218">
        <property type="entry name" value="facilitated trehalose transporter Tret1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050549">
        <property type="entry name" value="MFS_Trehalose_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021:SF1">
        <property type="entry name" value="GH07001P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="312"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="346"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="383"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="410"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="1"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0793640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="455" mass="49656" checksum="F1C5DC723E6F7D3E" modified="2020-02-26" version="1">MRRLTELFGKCRYMQYLAVTSGSWGSPSIPKLTSSDSPIGVTLSSEEVSWVASSPLLGFALGALTSSIPLKIIGPKWSLLSASLPIAGCWLGIAFSKSAVVLIVLRFLSGVCDGIIVTVGPLYIGEVADKDIRGKLITFFPIFSGLGNLIVLAVGPFVEYKTLNFICATVPILFATIFVFLPDSPYFLLRSGRGAESKRSLRRLLSNDVDDTTIDERLKEIEATIRSEGTHKFNVIHMFSKKHFRFAIFISLNTRLILAFGGMTVLKSYLQTIIGGTASSISPEISSLIFAIAQQPPVILTAFLVDRVGRKILLTISTLGCALMLGLEGIYFYLQRVAEIDLSAVSWLPTACLVIYSFMQPIGIGAMPSIIVGEIFADEIKSAAAGIPTTFSGSCHFLLAIFFLPISEAWGMHVMFWVFSVFCFYGAIFAMFVLPETKGKSFLEIQETLSKSRCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A8R6</accession>
    <name>A0A5N4A8R6_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_13341</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A8R6"/>
    <dbReference type="InParanoid" id="A0A5N4A8R6"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126:SF14">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126">
        <property type="entry name" value="ANKYRIN REPEAT, PH AND SEC7 DOMAIN CONTAINING PROTEIN SECG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024397385" evidence="4">
        <location>
            <begin position="23"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="476"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="509"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="542"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="575"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="608"/>
            <end position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0793721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="682" mass="70932" checksum="B965E3C47F987433" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A9Z4</accession>
    <name>A0A5N4A9Z4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PPYR_13762</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">1611_PpyrPB1</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0794142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A9Z4"/>
    <dbReference type="FunCoup" id="A0A5N4A9Z4">
        <property type="interactions" value="317"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A9Z4"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11056">
        <property type="entry name" value="CYP6-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000042">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050476">
        <property type="entry name" value="Insect_CytP450_Detox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292:SF100">
        <property type="entry name" value="CYTOCHROME P450 6A16, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 13" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13" id="KW-0408">Iron</keyword>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0492">Microsome</keyword>
    <keyword evidence="11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="489"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="441"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAB0794142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="991" mass="113715" checksum="531C1FD3ED7964BB" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AA95</accession>
    <name>A0A5N4AA95_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Allatostatin C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_13829</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0794209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AA95"/>
    <dbReference type="InParanoid" id="A0A5N4AA95"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0794209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="139" mass="15994" checksum="C53C9671016E4788" modified="2020-02-26" version="1">MVRVIYVRVPDSRRPNSRTFKSRRGIYLSSSTMPQQIMQFLMRSILLLLVLATVSTSARSTTHFGETNQINQEQDGSSGGLIDSGLTPLQLEMLAQRLSEYNQIPPIPAAWERLARNPEVKRQSRYRQCYFNPISCFRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AAI9</accession>
    <name>A0A5N4AAI9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DDE-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_11179</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0794340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AAI9"/>
    <dbReference type="InParanoid" id="A0A5N4AAI9"/>
    <dbReference type="OrthoDB" id="6777587at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF71">
        <property type="entry name" value="ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE-1" evidence="2">
        <location>
            <begin position="198"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0794340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="302" mass="34361" checksum="F1492A46747177F3" modified="2020-02-26" version="1">MIEALNKVKQGDSVNATAKRFNIPEATLRRYAKNYPNNNFPTSTGRFKTTFSEDQFLNLKKYVEDVDRRAFGVTREQFARIAFDYAESLNIPHRFNKDKKRAGKDFVQAFMTKFNFSLRKPEATSAARLAAFNKNNVESFFDLYKEILANKKFEPQQIYNIDETSCSTVPTKTPNVLSPTGNRRVVKVPSGERGVNVSVACCFNATGHYVPPFFIYPRVRMQSHFLANAPTGSGAACNESGWMKSETFVQWLEHFVKHVRPSNSNQILLLMDNHSSHVTLQAVNMCRENYISATYKPSYAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AAL9</accession>
    <name>A0A5N4AAL9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mif2/CENP-C cupin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_11193</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0794354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AAL9"/>
    <dbReference type="InParanoid" id="A0A5N4AAL9"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0794354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="281" mass="32137" checksum="11730CD927D52513" modified="2020-02-26" version="1">MSIALFNAEMSVSKIIEKRRQSLKAGLRLRLRSRAVRNLQECFEEASRPVNCSRKTRSKVRLKTNPENKTKSHGISKVKFTLAGGAEDLRRTRRTIRPPLKFMDLSFKSYRPKPLPPPSSPETKNKRQKLANVKQERPESRVVTPRTPLAVENLSYYSCVHTIINNKTLPITWYSTPTPTVGKFANPVEVFYTLKDIPAHGFTVSCGYMVISPDIEILEFPRSEVTMFKIENGKAIVKQQLKEVQMEKLFCFYVPLGSAYYIKNISCSKPLVLFFSKLTSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AAV9</accession>
    <name>A0A5N4AAV9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PPYR_11258</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0794419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AAV9"/>
    <dbReference type="FunCoup" id="A0A5N4AAV9">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AAV9"/>
    <dbReference type="OrthoDB" id="6481667at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050578">
        <property type="entry name" value="MARVEL-CKLF_proteins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22776:SF92">
        <property type="entry name" value="LD04844P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22776">
        <property type="entry name" value="MARVEL-CONTAINING POTENTIAL LIPID RAFT-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51225">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="7">
        <location>
            <begin position="25"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0794419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="162" mass="18352" checksum="1CD15129B33DA4C9" modified="2020-02-26" version="1">MSHTVTVTRTTTTTTTSALILNIGYLKTWPGIFKLFQLLLGIVNVGLVGYYYNERFITVPATFFLLMAVTFLVGTFLILLSCLASISTASIIAKTFYEFIYHLFAFILYLAASLTLLVHVNQYKRSYYYIYDEYTAASVIGLIISILYLLSAIFAYRSYKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AB35</accession>
    <name>A0A5N4AB35_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Metalloendopeptidase</fullName>
            <ecNumber evidence="11">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PPYR_11363</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="10 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10 11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="11"/>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0794524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AB35"/>
    <dbReference type="InParanoid" id="A0A5N4AB35"/>
    <dbReference type="OrthoDB" id="6665824at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04280">
        <property type="entry name" value="ZnMc_astacin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000015">
        <property type="entry name" value="Meprin A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034035">
        <property type="entry name" value="Astacin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF814">
        <property type="entry name" value="MEPRIN A SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 10 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10 11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 10 11" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0732">Signal</keyword>
    <keyword evidence="5 10 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024506096" description="Metalloendopeptidase" evidence="11">
        <location>
            <begin position="26"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12A" evidence="12">
        <location>
            <begin position="54"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAB0794524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="249" mass="28418" checksum="1D0D10DAA04ABBD0" modified="2020-02-26" version="1">MIRRLTFPSTMIVIVLLVSLALVQAVPAPLSDHDLWQRSGKFEGDMVLAPWQKNGVIDVKLRWTNRNIPYELSDDFDEQQKAQINEVLEREFAKTCISVKPRVGESDYVYVTGDNSGCWSQVGRLGGRQELNLKVRGCVWNHTIVHEFLHAAGFYHQQSSVDRDDFVDIFWENISKGLEHNFNKYNADFVTSFNETYDYGSIMHYAKTAFSSNGKPTILPKGDSTIPIGVTNVMSEIDIRKVKKMYDCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AB68</accession>
    <name>A0A5N4AB68_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquitin-like domain-containing CTD phosphatase 1</fullName>
            <ecNumber evidence="4">3.1.3.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Nuclear proteasome inhibitor UBLCP1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">PPYR_11415</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">1611_PpyrPB1</strain>
            <tissue evidence="21">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Peptidoglycan-recognition protein probably involved in innate immunity by binding to peptidoglycans (PGN) of bacteria and activating the prophenoloxidase (proPO) cascade immune response. Binds to 1,3-beta-D-glucan and PGN.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="4"/>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0794576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AB68"/>
    <dbReference type="InParanoid" id="A0A5N4AB68"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090364">
        <property type="term" value="P:regulation of proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06583">
        <property type="entry name" value="PGRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01813">
        <property type="entry name" value="Ubl_UBLCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.80.10:FF:000001">
        <property type="entry name" value="Peptidoglycan recognition protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000060">
        <property type="entry name" value="ubiquitin-like domain-containing CTD phosphatase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.80.10">
        <property type="entry name" value="Peptidoglycan recognition protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036505">
        <property type="entry name" value="Amidase/PGRP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002502">
        <property type="entry name" value="Amidase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011943">
        <property type="entry name" value="HAD-SF_hydro_IIID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006619">
        <property type="entry name" value="PGRP_domain_met/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051658">
        <property type="entry name" value="UBLCP1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02245">
        <property type="entry name" value="HAD_IIID1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48493">
        <property type="entry name" value="UBIQUITIN-LIKE DOMAIN-CONTAINING CTD PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48493:SF1">
        <property type="entry name" value="UBIQUITIN-LIKE DOMAIN-CONTAINING CTD PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01510">
        <property type="entry name" value="Amidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00644">
        <property type="entry name" value="Ami_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00701">
        <property type="entry name" value="PGRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55846">
        <property type="entry name" value="N-acetylmuramoyl-L-alanine amidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0391">Immunity</keyword>
    <keyword evidence="6" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="7" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="19">
        <location>
            <begin position="231"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="FCP1 homology" evidence="20">
        <location>
            <begin position="364"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00057187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAB0794576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="703" mass="81341" checksum="44D6425C3774FCCE" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ABR5</accession>
    <name>A0A5N4ABR5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PIN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PPYR_11602</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0794763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A5N4ABR5">
        <property type="interactions" value="1720"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4ABR5"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005697">
        <property type="term" value="C:telomerase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070034">
        <property type="term" value="F:telomerase RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09885">
        <property type="entry name" value="PIN_Smg6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000047">
        <property type="entry name" value="Blast:Telomerase-binding protein EST1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018834">
        <property type="entry name" value="DNA/RNA-bd_Est1-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019458">
        <property type="entry name" value="Est1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045153">
        <property type="entry name" value="Est1/Ebs1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15696">
        <property type="entry name" value="SMG-7 SUPPRESSOR WITH MORPHOLOGICAL EFFECT ON GENITALIA PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15696:SF0">
        <property type="entry name" value="TELOMERASE-BINDING PROTEIN EST1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10374">
        <property type="entry name" value="EST1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10373">
        <property type="entry name" value="EST1_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13638">
        <property type="entry name" value="PIN_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PIN" evidence="7">
        <location>
            <begin position="1368"/>
            <end position="1520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="297"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="478"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="603"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="932"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="978"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="98"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="262"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="299"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="375"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="394"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="428"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="478"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="496"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="513"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="551"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="627"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="932"/>
            <end position="957"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0794763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1542" mass="177231" checksum="457CC12B2B8FF029" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ADQ1</accession>
    <name>A0A5N4ADQ1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Medium-chain acyl-CoA ligase ACSF2, mitochondrial</fullName>
            <ecNumber evidence="4">6.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PPYR_12285</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Acyl-CoA synthases catalyze the initial reaction in fatty acid metabolism, by forming a thioester with CoA. Has some preference toward medium-chain substrates. Plays a role in adipocyte differentiation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a medium-chain fatty acid + ATP + CoA = a medium-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:48340"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:59558"/>
            <dbReference type="ChEBI" id="CHEBI:90546"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>octanoate + ATP + CoA = octanoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:33631"/>
            <dbReference type="ChEBI" id="CHEBI:25646"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57386"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.2" evidence="4"/>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0795446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ADQ1"/>
    <dbReference type="InParanoid" id="A0A5N4ADQ1"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000008">
        <property type="entry name" value="2,3-dihydroxybenzoate-AMP ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF5">
        <property type="entry name" value="MEDIUM-CHAIN ACYL-COA LIGASE ACSF2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="8">
        <location>
            <begin position="48"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="9">
        <location>
            <begin position="483"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0795446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="570" mass="62936" checksum="81B2CD54FB9980AE" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AEV1</accession>
    <name>A0A5N4AEV1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutathione transferase</fullName>
            <ecNumber evidence="2">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PPYR_09892</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the GST superfamily. Sigma family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="2"/>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0795831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AEV1"/>
    <dbReference type="FunCoup" id="A0A5N4AEV1">
        <property type="interactions" value="320"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AEV1"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03192">
        <property type="entry name" value="GST_C_Sigma_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd03039">
        <property type="entry name" value="GST_N_Sigma_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000030">
        <property type="entry name" value="Glutathione S-transferase S1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000035">
        <property type="entry name" value="hematopoietic prostaglandin D synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050213">
        <property type="entry name" value="GST_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571:SF224">
        <property type="entry name" value="HEMATOPOIETIC PROSTAGLANDIN D SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01205">
        <property type="entry name" value="AMPS.1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00363">
        <property type="entry name" value="AMPS_(cytGST):_Alpha-__Mu-__Pi"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="6">
        <location>
            <begin position="3"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="7">
        <location>
            <begin position="82"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="GST N-terminal" evidence="6">
        <location>
            <begin position="202"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="7">
        <location>
            <begin position="281"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0795831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="403" mass="45964" checksum="3ED6D513D414F713" modified="2020-02-26" version="1">MAPAYKLTYFPVKGLGEAIRFLLSYGNIEFEDFRLESANWAKIKPTMPFGQVPVLEFSGITAYQSIAICRYVAKQVKLTGANDLEDLEIDAIVDTINDMRTKISAYYHETDEIIKEILRKVLFDETIPYYMERIEAITKKNKGHLAAGKLTWADFYFVGVLDTLNVICGKNLIADCPSLQVMQQNVLSLPGVKEWVAKPMVPAYKLTYCPVKALAEPIRLLMSYGNIEFEDFRFDMDDWPQIKATTPFGQVPVLEFKGTTAYQSIAICRYLAKQVKLTGANDIEDLEIDAVVDTVMDLRTKIVEYFYEEDAAVKERRRKPLFEETLPFYMKRMEAAAKKNKSHLAAGKLTWADVHFVGIVDYLSFMIGRDLLADCPSLQVMQKTVLKLPGIKEWVVKRPVTDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AF04</accession>
    <name>A0A5N4AF04_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peptidase metallopeptidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PPYR_09955</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="8">Can bind about 5 Ca(2+) ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M10A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0795894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AF04"/>
    <dbReference type="InParanoid" id="A0A5N4AF04"/>
    <dbReference type="OrthoDB" id="10030048at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030574">
        <property type="term" value="P:collagen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04278">
        <property type="entry name" value="ZnMc_MMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033739">
        <property type="entry name" value="M10A_MMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001818">
        <property type="entry name" value="Pept_M10_metallopeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021190">
        <property type="entry name" value="Pept_M10A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201">
        <property type="entry name" value="MATRIX METALLOPROTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201:SF169">
        <property type="entry name" value="MATRIX METALLOPROTEINASE-16-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00413">
        <property type="entry name" value="Peptidase_M10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00138">
        <property type="entry name" value="MATRIXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="PGBD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024440023" description="Peptidase metallopeptidase domain-containing protein" evidence="9">
        <location>
            <begin position="19"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase metallopeptidase" evidence="10">
        <location>
            <begin position="95"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <feature type="binding site" description="in inhibited form" evidence="8">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR621190-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR621190-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0795894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="254" mass="28232" checksum="3111AF6141321503" modified="2020-02-26" version="1">MKGLLIVTLAIFAAGVYAAPAISSEDQVHNYLVRFGYATKEDLQNRASLTDAIKKLQRMGKVPETGVIDEATIELIKKPRCGVADYENGKPRYNAYKGWTKKQVEFYIGTGTSYLTHEEYSSYFGAALRLWSGHTSGTTFHPTTNKSEADIITYFGSHDHGDGYPFDGRGGVLAHAFFPDDGDVHFDASEKWDIDGMGDYTSFYSVAVHELGHSMGLEHSEVEEAVMYPWYKGGGIDKLHQDDIDGMNKLYASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AFA2</accession>
    <name>A0A5N4AFA2_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PPYR_10037</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0795976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AFA2"/>
    <dbReference type="InParanoid" id="A0A5N4AFA2"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049012">
        <property type="entry name" value="Mutator_transp_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF74">
        <property type="entry name" value="POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
        <property type="entry name" value="HTH_psq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20700">
        <property type="entry name" value="Mutator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="5">
        <location>
            <begin position="61"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="414"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="473"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="414"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="481"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0795976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="687" mass="78274" checksum="5E5C84F96946178C" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AFG0</accession>
    <name>A0A5N4AFG0_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_10100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AFG0"/>
    <dbReference type="InParanoid" id="A0A5N4AFG0"/>
    <dbReference type="OrthoDB" id="6344725at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2080.10">
        <property type="entry name" value="Insect odorant-binding protein A10/Ejaculatory bulb-specific protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005055">
        <property type="entry name" value="A10/PebIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036682">
        <property type="entry name" value="OS_D_A10/PebIII_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11257">
        <property type="entry name" value="CHEMOSENSORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11257:SF12">
        <property type="entry name" value="EJACULATORY BULB-SPECIFIC PROTEIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03392">
        <property type="entry name" value="OS-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100910">
        <property type="entry name" value="Chemosensory protein Csp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024336135" evidence="1">
        <location>
            <begin position="17"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0796039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="126" mass="14676" checksum="199800D9911175C0" modified="2020-02-26" version="1">MKLIVLVCLVIVVVYAKDEPPYTTKYDDIDVDEILANKRLTLYYADCLLGKGKCNDQGQTLKDIVPDALNNECKRCSEKQKEATEKVLRYLAKHYRDIWNSLIAHFDKDGKHRDQYKKYIDEMEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AG51</accession>
    <name>A0A5N4AG51_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase-like protein 22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_10327</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AG51"/>
    <dbReference type="InParanoid" id="A0A5N4AG51"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038899">
        <property type="entry name" value="METTL22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23108:SF0">
        <property type="entry name" value="METHYLTRANSFERASE-LIKE PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23108">
        <property type="entry name" value="METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0796266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="136" mass="15372" checksum="43A630EF09C6769B" modified="2020-02-26" version="1">MEVSSELYSEFEYETDSKPTVDPCNVVSKFSFIYPISPTVTDSDGDLVVRRKSEEKRGIIEIEHSKRTELSLVGLQVWRGALLLADWILYIREELIKRNLKILELGSGTGLTSIVASMFSDVICTDVNKVIDTRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AI20</accession>
    <name>A0A5N4AI20_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_11066</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0797005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AI20"/>
    <dbReference type="InParanoid" id="A0A5N4AI20"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000068">
        <property type="entry name" value="transmembrane protease serine 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050430">
        <property type="entry name" value="Peptidase_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276:SF96">
        <property type="entry name" value="PEPTIDASE S1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276">
        <property type="entry name" value="POLYSERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024286996" description="Peptidase S1 domain-containing protein" evidence="7">
        <location>
            <begin position="16"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="8">
        <location>
            <begin position="24"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0797005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="252" mass="27583" checksum="BEC0F390C632D259" modified="2020-02-26" version="1">MSRFLLLLLSSSVFGATLKKDKRIADGQPAGEGAFPYLVSIRIDGQHECAGSILDATTILTAAHCLFGFQQMSMTVTAGSITLDTGGDTYEVSVRRTHEFYDPYTTRGFKNDIGILKLKTAIKFSDKVQPIRYLAAGDVGVSVHCILPGWGITKEDGDRSNELRFVNLLTIPTETCSETWLASEYKFSIDDRQLCTFTQDGQGACRGDSGGPLIVGTGLQIGIASMALRCGIGPNVYTKVAYYRDWIERNRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AIA9</accession>
    <name>A0A5N4AIA9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PPYR_11090</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">1611_PpyrPB1</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0797029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AIA9"/>
    <dbReference type="InParanoid" id="A0A5N4AIA9"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11056">
        <property type="entry name" value="CYP6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000042">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050476">
        <property type="entry name" value="Insect_CytP450_Detox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292:SF54">
        <property type="entry name" value="CYP9F3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0492">Microsome</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="470"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAB0797029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="525" mass="60137" checksum="AFDBA9CFDA7373E9" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AIQ7</accession>
    <name>A0A5N4AIQ7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_08092</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AIQ7"/>
    <dbReference type="InParanoid" id="A0A5N4AIQ7"/>
    <dbReference type="OrthoDB" id="19132at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045165">
        <property type="term" value="P:cell fate commitment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042051">
        <property type="term" value="P:compound eye photoreceptor development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002009">
        <property type="term" value="P:morphogenesis of an epithelium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061061">
        <property type="term" value="P:muscle structure development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048477">
        <property type="term" value="P:oogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045466">
        <property type="term" value="P:R7 cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18315">
        <property type="entry name" value="BTB_POZ_BAB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000091">
        <property type="entry name" value="Lola, isoform F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051095">
        <property type="entry name" value="Dros_DevTransReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23110">
        <property type="entry name" value="BTB DOMAIN TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23110:SF82">
        <property type="entry name" value="PROTEIN TRAMTRACK, ALPHA ISOFORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BTB" evidence="6">
        <location>
            <begin position="57"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="191"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="233"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="195"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="239"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="249"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0797098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="535" mass="60880" checksum="ECD8F9A278EEA16D" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AJ53</accession>
    <name>A0A5N4AJ53_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CHK kinase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_08379</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AJ53"/>
    <dbReference type="InParanoid" id="A0A5N4AJ53"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015897">
        <property type="entry name" value="CHK_kinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004119">
        <property type="entry name" value="EcKL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012">
        <property type="entry name" value="PROTEIN KINASE-LIKE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012:SF30">
        <property type="entry name" value="PROTEIN KINASE-LIKE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02958">
        <property type="entry name" value="EcKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00587">
        <property type="entry name" value="CHK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="301"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="CHK kinase-like" evidence="2">
        <location>
            <begin position="86"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0797385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="367" mass="42504" checksum="2BF7279E0320D181" modified="2020-02-26" version="1">MENSTNLIRLTASQMRELKQVIHTFGMDRYSLDLSLGAEENFGGIIIKADVLPEFVSIQKEFQIKKPFESYATYYSSLKIDREEMIILQNMKTLGLKQRERHLPLDYNHVLLTVKEYARLHALSYALHYHRPELFEELEQNMADPMYFDFKLEGVRQVLQHRCSEALKALSPTEDQSAYQKLLYFSDNAVSIVIKLLNSANPHRVVSHIDCGIPNLLFEYENASNAPIRVIMLDWQASRMESPAVDLVTFLFSATDKATRYRYNELISEYYGCLCSFLAEFGCDGKKLLPFEVLQQQLKEYGIMGLFMVIGLIYVYSTVNQRVPDIYKEESHAEGLSFLYDLDDSSCFSKRVREAILDFHNLGYNFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AL83</accession>
    <name>A0A5N4AL83_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cathepsin L</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PPYR_09059</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AL83"/>
    <dbReference type="InParanoid" id="A0A5N4AL83"/>
    <dbReference type="OrthoDB" id="190265at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000006">
        <property type="entry name" value="Cathepsin S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024370126" description="Cathepsin L" evidence="7">
        <location>
            <begin position="21"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="Cathepsin propeptide inhibitor" evidence="9">
        <location>
            <begin position="110"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="8">
        <location>
            <begin position="202"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0798066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="422" mass="46865" checksum="4B17CE4CD90DD651" modified="2020-02-26" version="1">MFLQALRIFVVVLYFKNITSEKNDTKTIHTRQTPTNFDVVRTETRRIPLLTAVPRLLTSPQNYFQTDAFGPQQSFSAIPQKTIRIQAPAVKSKVQIITSLSTDDILELEWSNFKKTFQKNYSTLTEDRQRKEIFIENRNKVAKFNQAYGFGYHSFVKKLNEYADMLHHEFNHQLNGFNRTDARGRSAGSVPSAFIRSENAETPIRVDWSEFGAVSSVKSQGKCGACYAFASAGALEGQHFRKTGQLLDLSVQNIIDCSTPYSNNGCVGGVMDKSYEYIKDNKGVATEAAYPFEGKDGLECRYTPEKYGAHATGHVVIDEGDENSLESAVAHLGPVSVAIDASPDSFQFYSSGVYFEPSCQPGLETLNHAVLVVGYGTEPNGQDYWLIKNSYGAGWGIGGYMKIAKFANNHCGIASFASYPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ALI9</accession>
    <name>A0A5N4ALI9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PPYR_09193</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">1611_PpyrPB1</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein heavy chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A5N4ALI9">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4ALI9"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097729">
        <property type="term" value="C:9+2 motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005858">
        <property type="term" value="C:axonemal dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001221">
        <property type="entry name" value="Axonemal dynein heavy chain 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.1220:FF:000001">
        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.710:FF:000003">
        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1120:FF:000004">
        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.30:FF:000004">
        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.180.20:FF:000001">
        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002141">
        <property type="entry name" value="Dynein heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.20:FF:000001">
        <property type="entry name" value="dynein heavy chain 2, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.720:FF:000004">
        <property type="entry name" value="Dynein heavy chain 5, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.280:FF:000002">
        <property type="entry name" value="Dynein heavy chain 5, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.490.20:FF:000003">
        <property type="entry name" value="Dynein heavy chain 5, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000044">
        <property type="entry name" value="Dynein heavy chain 5, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.2620:FF:000003">
        <property type="entry name" value="Dynein, axonemal, heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.100:FF:000003">
        <property type="entry name" value="Dynein, axonemal, heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000049">
        <property type="entry name" value="Dynein, axonemal, heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000320">
        <property type="entry name" value="Dynein, axonemal, heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001080">
        <property type="entry name" value="Dynein, axonemal, heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.100">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.20">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.720">
        <property type="entry name" value="Region D6 of dynein motor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035699">
        <property type="entry name" value="AAA_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035706">
        <property type="entry name" value="AAA_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041658">
        <property type="entry name" value="AAA_lid_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042219">
        <property type="entry name" value="AAA_lid_11_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041589">
        <property type="entry name" value="DNAH3_AAA_lid_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042222">
        <property type="entry name" value="Dynein_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043157">
        <property type="entry name" value="Dynein_AAA1S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041466">
        <property type="entry name" value="Dynein_AAA5_ext"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041228">
        <property type="entry name" value="Dynein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043160">
        <property type="entry name" value="Dynein_C_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024743">
        <property type="entry name" value="Dynein_HC_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024317">
        <property type="entry name" value="Dynein_heavy_chain_D4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004273">
        <property type="entry name" value="Dynein_heavy_D6_P-loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013602">
        <property type="entry name" value="Dynein_heavy_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013594">
        <property type="entry name" value="Dynein_heavy_tail"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042228">
        <property type="entry name" value="Dynein_linker_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46532:SF4">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46532">
        <property type="entry name" value="MALE FERTILITY FACTOR KL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12774">
        <property type="entry name" value="AAA_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12775">
        <property type="entry name" value="AAA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12780">
        <property type="entry name" value="AAA_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12781">
        <property type="entry name" value="AAA_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17857">
        <property type="entry name" value="AAA_lid_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18198">
        <property type="entry name" value="AAA_lid_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08385">
        <property type="entry name" value="DHC_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08393">
        <property type="entry name" value="DHC_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17852">
        <property type="entry name" value="Dynein_AAA_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18199">
        <property type="entry name" value="Dynein_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03028">
        <property type="entry name" value="Dynein_heavy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12777">
        <property type="entry name" value="MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0966">Cell projection</keyword>
    <keyword evidence="10" id="KW-0969">Cilium</keyword>
    <keyword evidence="9 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0243">Dynein</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="15">
        <location>
            <begin position="1927"/>
            <end position="2063"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="15">
        <location>
            <begin position="2206"/>
            <end position="2335"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="15">
        <location>
            <begin position="2533"/>
            <end position="2681"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="599"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="3378"/>
            <end position="3433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAB0798200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="4526" mass="521271" checksum="811C7AABFC771E73" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ALX1</accession>
    <name>A0A5N4ALX1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FYVE-type zinc finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_09348</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ALX1"/>
    <dbReference type="InParanoid" id="A0A5N4ALX1"/>
    <dbReference type="OrthoDB" id="10072397at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="624"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="950"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="625"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0798355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1008" mass="112178" checksum="AFB04046CCEDA695" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AMT6</accession>
    <name>A0A5N4AMT6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_09665</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AMT6"/>
    <dbReference type="InParanoid" id="A0A5N4AMT6"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021896">
        <property type="entry name" value="THAP9-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055035">
        <property type="entry name" value="THAP9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048366">
        <property type="entry name" value="TNP-like_GBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048367">
        <property type="entry name" value="TNP-like_RNaseH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048365">
        <property type="entry name" value="TNP-like_RNaseH_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47577:SF2">
        <property type="entry name" value="THAP DOMAIN CONTAINING 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47577">
        <property type="entry name" value="THAP DOMAIN-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22824">
        <property type="entry name" value="THAP9_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21788">
        <property type="entry name" value="TNP-like_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21789">
        <property type="entry name" value="TNP-like_RNaseH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21787">
        <property type="entry name" value="TNP-like_RNaseH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12017">
        <property type="entry name" value="Tnp_P_element"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00692">
        <property type="entry name" value="DM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0798672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="898" mass="101738" checksum="3C92669B14A6EC54" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AN64</accession>
    <name>A0A5N4AN64_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_06626</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0798746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AN64"/>
    <dbReference type="FunCoup" id="A0A5N4AN64">
        <property type="interactions" value="169"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AN64"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0798746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="415" mass="44999" checksum="EA63C5224396C252" modified="2020-02-26" version="1">MCSYKSGRSAREKRILVVYGEYKGGIIGGGSGSGNDNLILYICLTVGAIVLIIIIVILLCCYCKRSSRQSRSKNNDTSQSTDYVSLNGRPEHEKALITEVNPIVKPPRQYSVPPSVTSGITEVSDIKKTLLDDDSTFGAGDEDSRSFDFDSRPRVPIHHLEADYRNDNQQPDLLAFPARGIQVSPAGSTASTVADHSRLPPHHGPQSPIHSPLYDSVSLYRTLPYSRSQSPFTSPLGAPVVTPRAGGYVTIPRRPRASWSSEPLNPMFVDPVYDNLGLRTTAAGNSALSLNKIGETSTPKIPRNANPSTPASSVPWHPIAEHEAIGVSATLPKNSASLRAPTNEFQKPNWIRNTSDTSSLKSIDNDSRRQSTSSLLPTTPDGKITKIPPRPPPKPKKRISTGPLFEDEGEDGTEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4APA8</accession>
    <name>A0A5N4APA8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Transient receptor ion channel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PPYR_06928</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">1611_PpyrPB1</strain>
            <tissue evidence="19">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cell projection</location>
            <location evidence="13">Rhabdomere membrane</location>
            <topology evidence="13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A5N4APA8">
        <property type="interactions" value="83"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4APA8"/>
    <dbReference type="OrthoDB" id="2373987at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034703">
        <property type="term" value="C:cation channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033583">
        <property type="term" value="C:rhabdomere membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070679">
        <property type="term" value="F:inositol 1,4,5 trisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015279">
        <property type="term" value="F:store-operated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050877">
        <property type="term" value="P:nervous system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051480">
        <property type="term" value="P:regulation of cytosolic calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000221">
        <property type="entry name" value="Transient receptor potential-gamma protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013555">
        <property type="entry name" value="TRP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002153">
        <property type="entry name" value="TRPC_channel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00870">
        <property type="entry name" value="trp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10117">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10117:SF47">
        <property type="entry name" value="TRANSIENT-RECEPTOR-POTENTIAL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08344">
        <property type="entry name" value="TRP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01097">
        <property type="entry name" value="TRNSRECEPTRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01420">
        <property type="entry name" value="TRP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="3" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0966">Cell projection</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="360"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="537"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="627"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="15">
        <location>
            <begin position="139"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Transient receptor ion channel" evidence="18">
        <location>
            <begin position="174"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1023"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1102"/>
            <end position="1286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1037"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1107"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1231"/>
            <end position="1246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1254"/>
            <end position="1269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00043946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00060916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM01420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAB0799048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1286" mass="145759" checksum="070D8D77C43CCC0F" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4APE1</accession>
    <name>A0A5N4APE1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CN hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_07095</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4APE1"/>
    <dbReference type="InParanoid" id="A0A5N4APE1"/>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040154">
        <property type="entry name" value="Biotinidase/VNN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043957">
        <property type="entry name" value="Vanin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10609:SF14">
        <property type="entry name" value="BIOTINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10609">
        <property type="entry name" value="BIOTINIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19018">
        <property type="entry name" value="Vanin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024306455" description="CN hydrolase domain-containing protein" evidence="3">
        <location>
            <begin position="19"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="CN hydrolase" evidence="4">
        <location>
            <begin position="22"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0799215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="519" mass="57875" checksum="84BB5A30FF5ADCB4" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-06-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4APS8</accession>
    <name>A0A5N4APS8_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_07204</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4APS8"/>
    <dbReference type="InParanoid" id="A0A5N4APS8"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="59"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0799324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="121" mass="14241" checksum="224BF77248784AA1" modified="2020-02-26" version="1">MAMKVSSRTLLLIEKSQVRQNSDKVTMSSDVKDFEEEFQAEADISSIYGNSYITQKTIVNQLHLEIDVLERMLKRKKKQVLREENVLSTYKKMYNSIVPNKRKKRDCVYQHFDCLNCSDKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4APX9</accession>
    <name>A0A5N4APX9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PPYR_07148</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4APX9"/>
    <dbReference type="InParanoid" id="A0A5N4APX9"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000026">
        <property type="entry name" value="Transposon Ty3-G Gag-Pol polyprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="11">
        <location>
            <begin position="226"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="12">
        <location>
            <begin position="468"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="158"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAB0799268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="938" mass="107815" checksum="5C2C1D222564F91D" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2024-05-29" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4APZ1</accession>
    <name>A0A5N4APZ1_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_07277</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4APZ1"/>
    <dbReference type="InParanoid" id="A0A5N4APZ1"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0799397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="65" mass="7436" checksum="73C3DCE8D064F676" modified="2020-02-26" version="1">MGNFKQINSQYQASNIANPCLKNGSNSDLSQIYRETDFSYSLFTCTVSFQLSMRLLFPSCRDIIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ARA9</accession>
    <name>A0A5N4ARA9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Scavenger receptor class B member 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_07744</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CD36 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ARA9"/>
    <dbReference type="FunCoup" id="A0A5N4ARA9">
        <property type="interactions" value="56"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4ARA9"/>
    <dbReference type="OrthoDB" id="514335at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005044">
        <property type="term" value="F:scavenger receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002159">
        <property type="entry name" value="CD36_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11923:SF114">
        <property type="entry name" value="FI02050P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11923">
        <property type="entry name" value="SCAVENGER RECEPTOR CLASS B TYPE-1 SR-B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01130">
        <property type="entry name" value="CD36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01609">
        <property type="entry name" value="CD36FAMILY"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="439"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0799864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="479" mass="54701" checksum="D7E898876B3E8E1E" modified="2020-02-26" version="1">MSSKKLLFSGIVLTTLGVILLVFWTKICTTVLHSKLVLSNTSLSFKLWKDPPIPIHLSIYLFDWENAETVIKSEWKVKPRFEEKGPFVFSEHHVREISSWNGNGTVSYQQRRIWKFVQSMSNGSLLDNITSVNPIVVILGQKVKNIRFIGPVINSILWYFDEKLYVTKTVNEWLFEGYEDPIISDLVEYHIPGVEIPFDRIGWLYSRNDSATYEGNFTVYTGINDINKLGEMNLWNGRGKTDAYDYPCSLLDGSSGELYSPFNQKQHLSIFLTDICSTLTLERNDTEEVFGIEGAKFIGTDYNFDNGSKYNRQKCFTRNSLPSGVRDISKCKYGAPAFVSYPHFYLADHSYGANVEGLKPDKARHETHITLEPNTGVPLNASAKLQLNLFVDNVKGISVFDNVVPTYMPILWFQEDASLTEKYCNLIGIFQKVLSGGFYFGYVLFGVGLFTMLFAWYSMNGLICRRRYTDLLAEEENES</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ARS8</accession>
    <name>A0A5N4ARS8_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_07907</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the mab-21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0800027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ARS8"/>
    <dbReference type="FunCoup" id="A0A5N4ARS8">
        <property type="interactions" value="125"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4ARS8"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1410.40:FF:000002">
        <property type="entry name" value="protein mab-21-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.90:FF:000001">
        <property type="entry name" value="protein mab-21-like 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046903">
        <property type="entry name" value="Mab-21-like_nuc_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046906">
        <property type="entry name" value="Mab-21_HhH/H2TH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024810">
        <property type="entry name" value="MAB21L/cGLR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10656">
        <property type="entry name" value="CELL FATE DETERMINING PROTEIN MAB21-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10656:SF70">
        <property type="entry name" value="PROTEIN MAB-21-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03281">
        <property type="entry name" value="Mab-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20266">
        <property type="entry name" value="Mab-21_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01265">
        <property type="entry name" value="Mab-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mab-21-like nucleotidyltransferase" evidence="2">
        <location>
            <begin position="68"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Mab-21-like HhH/H2TH-like" evidence="3">
        <location>
            <begin position="252"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0800027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="365" mass="41806" checksum="C394AE253B5A3C19" modified="2020-02-26" version="1">MLVPPDMLAAQSKMLYQINKYYGERVQTRMGTIAKTIREVCKVVQDVLKEVEVQEPRFISSLTECNGRYEGLEVVSPTEFEVVLYLNQMGVFNFVDDGTLPGCAVLKLSDGRKRSMSLWVEFITASGYLSARKIRSRFQTLVAQACDKCSYRDCVKMISETTEVKLRIRERYVVQITPAFKCSGVWPRSAAHWPIPHIPWPHPNLVAEVKTEGFDLLSKESVAIQGKQSAMEGDAWVLSFNEAENRLLQGGCRRRCLSILKTLRDRHLDLPGNPVTSYHMKTLLLYECEKHPRESEWDESCIGDRINGIFLQLISCLQCKRCPHYFLPNLDLFKGKSPSALENASKQVWRLTREMLTNTRCLEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ARU1</accession>
    <name>A0A5N4ARU1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Synembryn</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PPYR_07896</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cell cortex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the synembryn family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0800016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ARU1"/>
    <dbReference type="FunCoup" id="A0A5N4ARU1">
        <property type="interactions" value="1738"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4ARU1"/>
    <dbReference type="OrthoDB" id="5585685at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001965">
        <property type="term" value="F:G-protein alpha-subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008376">
        <property type="entry name" value="Chaperone_Ric-8_A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019318">
        <property type="entry name" value="Gua_nucleotide_exch_fac_Ric8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12425">
        <property type="entry name" value="SYNEMBRYN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12425:SF5">
        <property type="entry name" value="SYNEMBRYN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10165">
        <property type="entry name" value="Ric8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01802">
        <property type="entry name" value="SYNEMBRYN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0800016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="533" mass="60273" checksum="A1CE935C8641ABF7" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ARV7</accession>
    <name>A0A5N4ARV7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Transportin-3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PPYR_07962</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Importin, which transports target proteins into the nucleus. Specifically mediates the nuclear import of splicing factor serine/arginine (SR) proteins, such as RBM4, SFRS1 and SFRS2, by recognizing phosphorylated SR domains. Also mediates the nuclear import of serine/arginine (SR) protein CPSF6, independently of CPSF6 phosphorylation. The nuclear import process is regulated by the small GTPase Ran that partitions between cytoplasm and nucleus in the predominantly GDP- and GTP-bound form, respectively. Importin associates with target cargo proteins in the cytoplasm, and the competitive binding of GTP-bound Ran induces the release of cargos in the nucleus.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with (GTP-bound) Ran. Interacts with (phosphorylated) SFRS1 and SFRS2; leading to their nuclear import. Interacts with NUP62. Interacts with RBM4. Interacts with CPSF6, promoting its nuclear import.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus envelope</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0800082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ARV7"/>
    <dbReference type="FunCoup" id="A0A5N4ARV7">
        <property type="interactions" value="2644"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4ARV7"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000079">
        <property type="entry name" value="transportin-3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051345">
        <property type="entry name" value="Importin_beta-like_NTR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057941">
        <property type="entry name" value="TPR_TNPO3_IPO13_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057942">
        <property type="entry name" value="TPR_TNPO3_IPO13_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058537">
        <property type="entry name" value="TPR_TNPO3_IPO13_4th"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12363">
        <property type="entry name" value="TRANSPORTIN 3 AND IMPORTIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12363:SF42">
        <property type="entry name" value="TRANSPORTIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24138">
        <property type="entry name" value="TPR_TNPO3_IPO13_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24140">
        <property type="entry name" value="TPR_TNPO3_IPO13_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24139">
        <property type="entry name" value="TPR_TNPO3_IPO13_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="12">
        <location>
            <begin position="29"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00060097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00063116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00067328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAB0800082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="936" mass="106277" checksum="22EBF1B04879A975" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AS74</accession>
    <name>A0A5N4AS74_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_08003</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0800123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AS74"/>
    <dbReference type="FunCoup" id="A0A5N4AS74">
        <property type="interactions" value="1340"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AS74"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161:SF85">
        <property type="entry name" value="PALMITOYLTRANSFERASE HIP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="314"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="369"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="72"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="106"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="139"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="207"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0800123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="411" mass="45446" checksum="F9EA3C9C484EBBF4" modified="2020-02-26" version="1">MYQNACGAAAASAGGCVEADRECHSLISKEPIVPAEHDYSGFDIVKATQYGAYQRVKDLIDAGYNVNQRDSETVTLLHWAAINNRKEIMRFFIDNGSEVDAVGGELDATPLHWATRQGHLDAVVLLMNAGADPTLRDAEGCSCIHLAAQFGHTALVAYFVARGVSPDLQDRGGMTPLMWSCWKVCSLDPTRLLLTLGASTKLTDSTQGNTALHWAILSRNTTAISTLIIQSNASLDIPNHRGDTPLALLQNCSGSVWIGAKVGDRIREAMNSNRSQNMFIRISKDKRVKWWCMVGTPFISFYIAGLILSANVLILIKIFLLVCLYIVLHFIGQVFYDDRLMALLPLSIYLATKIWIYITWIIYIMPHTAIFLTLTFLSSSGALWYCFLKAWLGDPGVISTTKDLQFRVSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ASB3</accession>
    <name>A0A5N4ASB3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Choline O-acetyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PPYR_05967</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the carnitine/choline acetyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.6" evidence="5"/>
    <dbReference type="EMBL" id="VVIM01000004">
        <property type="protein sequence ID" value="KAB0800227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ASB3"/>
    <dbReference type="FunCoup" id="A0A5N4ASB3">
        <property type="interactions" value="85"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4ASB3"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004102">
        <property type="term" value="F:choline O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008292">
        <property type="term" value="P:acetylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007274">
        <property type="term" value="P:neuromuscular synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.70">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000542">
        <property type="entry name" value="Carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039551">
        <property type="entry name" value="Cho/carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042231">
        <property type="entry name" value="Cho/carn_acyl_trans_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589">
        <property type="entry name" value="CARNITINE O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589:SF14">
        <property type="entry name" value="CHOLINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00755">
        <property type="entry name" value="Carn_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00439">
        <property type="entry name" value="ACYLTRANSF_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00440">
        <property type="entry name" value="ACYLTRANSF_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0530">Neurotransmitter biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Choline/carnitine acyltransferase" evidence="10">
        <location>
            <begin position="105"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600542-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0800227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="736" mass="82083" checksum="609AEF3B0EB6FD6E" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ASE5</accession>
    <name>A0A5N4ASE5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_06004</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000004">
        <property type="protein sequence ID" value="KAB0800264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ASE5"/>
    <dbReference type="InParanoid" id="A0A5N4ASE5"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF71">
        <property type="entry name" value="ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
        <property type="entry name" value="HTH_psq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH psq-type" evidence="3">
        <location>
            <begin position="15"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="DDE-1" evidence="2">
        <location>
            <begin position="216"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0800264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="353" mass="39825" checksum="CA17238D469D1D59" modified="2020-02-26" version="1" fragment="single">MAPRKTNRQSWSEIAMAEAIKAVSTGEFGYLKASKVFSVPKSTLERRVKGFNKQISGSAKGLGSRQQTFSIVLEEQLVAYIKNMECMLFGLTTTDVRRLAYQFAERNNIRHFFNANKKMAGWVWLRAFMKRNRLSLRTPEATSAARARGFNRVSVDKFFELLEPLQDKNKYTPSRIFNVDETGMSTVQGHPSKIIAMRDRKQVGTLSSAERGTLSTAVICMSASGSFIPPMMIYPRVRNKEEFSIGVPPETLVACHPSGWMQLNLFDHFVKHSMASVENPALLIMDGHKTHTQNIAVIEKARNNGVTILCLPPHCSHRMQPLDVAFMGPLSTFYNQEVEIFLRNNPGRVVTIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ATV2</accession>
    <name>A0A5N4ATV2_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PPYR_06544</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">1611_PpyrPB1</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000004">
        <property type="protein sequence ID" value="KAB0800805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ATV2"/>
    <dbReference type="InParanoid" id="A0A5N4ATV2"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001607">
        <property type="term" value="F:neuromedin U receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005390">
        <property type="entry name" value="NeuromedU_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF208">
        <property type="entry name" value="PYROKININ-1 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01565">
        <property type="entry name" value="NEUROMEDINUR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 12" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 12" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="64"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="185"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="14">
        <location>
            <begin position="84"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAB0800805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="332" mass="37553" checksum="62EF4C2A505FCC42" modified="2020-02-26" version="1" fragment="single">MQDRGSTFYEYNYATDEDQMKRSLLTNISESPIITNVTLPSQVSSRFPILSYEVSDWGPKRDSLYVVVPITLLYVAIFITGLLGNICTCIVIARNKSMHTATNYYLFSLAISDLLLLISGLPTEIYSTWSKYPYVFGEIFCILQGFAAETSANATVLTITAFTIERYVAICHPFLSHTMSKLSRAVKYIIVIWLLAMCLALPQAMAFGIFYEQYPDGYGTSNDHYVCTVKRIVIPHAFEISTFVFFIAPMTVITILYVLIGIRIHKSTSARNRDGSIKLKHYKNKTCVQSPNKKMKVMLGSNSDNIKIMYEDAGRKNYSRNSQASKHVVEML</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AUC7</accession>
    <name>A0A5N4AUC7_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PPYR_05270</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000003">
        <property type="protein sequence ID" value="KAB0800916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AUC7"/>
    <dbReference type="InParanoid" id="A0A5N4AUC7"/>
    <dbReference type="OrthoDB" id="6624577at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001234">
        <property type="term" value="P:negative regulation of apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006214">
        <property type="entry name" value="Bax_inhibitor_1-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291">
        <property type="entry name" value="BAX INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291:SF127">
        <property type="entry name" value="PROTEIN LIFEGUARD 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01027">
        <property type="entry name" value="Bax1-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0800916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="343" mass="39167" checksum="6BBB057783CD076C" modified="2020-02-26" version="1">MNGIGIDVTAHKVITTRNIILFNEDNPNIKEPNESILFLDNVINSAARAKNQSNRYDNRIQEAAGSGQATYYQQHMIGNQPQYAQDLAQNNTESRVFIRNSDQYEYSRTELIFISSFENQRIRGRFIQRVYTILGIQLSCMSGFIFVSTYVQPVKHQLQKHTLYVFLAMCIFLFVYLTLVCSRKARRSFPFNFVLLTIFTIALSYMLAILSLIYKTQIVLMSVGTTVVTTFAMAIMACQHSCDCTRCLPCLCVITSATILFGIILTLIAVTTQTPLVYAIYSAMIGFVFTSYLVFDTQMIMGGRRIQLSPEEYIYAVLTLYTDVVEILMNTLRTFNIFKKTQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AUN9</accession>
    <name>A0A5N4AUN9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Neuroglian</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PPYR_05446</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">1611_PpyrPB1</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000003">
        <property type="protein sequence ID" value="KAB0801092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AUN9"/>
    <dbReference type="FunCoup" id="A0A5N4AUN9">
        <property type="interactions" value="395"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AUN9"/>
    <dbReference type="OrthoDB" id="6244967at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098632">
        <property type="term" value="F:cell-cell adhesion mediator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007420">
        <property type="term" value="P:brain development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000035">
        <property type="entry name" value="Contactin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000004">
        <property type="entry name" value="DCC isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001928">
        <property type="entry name" value="neuroglian isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001718">
        <property type="entry name" value="Neuroglian, isoform D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001687">
        <property type="entry name" value="Neuroglian, isoform E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000005">
        <property type="entry name" value="Neuronal cell adhesion molecule"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000028">
        <property type="entry name" value="Neuronal cell adhesion molecule"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000032">
        <property type="entry name" value="palladin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013151">
        <property type="entry name" value="Immunoglobulin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026966">
        <property type="entry name" value="Neurofascin/L1/NrCAM_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170:SF6">
        <property type="entry name" value="CONTACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170">
        <property type="entry name" value="PROTEIN SIDEKICK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13882">
        <property type="entry name" value="Bravo_FIGEY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00047">
        <property type="entry name" value="ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 15" id="KW-0732">Signal</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024307826" description="Neuroglian" evidence="15">
        <location>
            <begin position="19"/>
            <end position="1252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1122"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="16">
        <location>
            <begin position="25"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="16">
        <location>
            <begin position="143"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="16">
        <location>
            <begin position="241"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="16">
        <location>
            <begin position="334"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="16">
        <location>
            <begin position="427"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="16">
        <location>
            <begin position="516"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="17">
        <location>
            <begin position="609"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="17">
        <location>
            <begin position="708"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="17">
        <location>
            <begin position="813"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="17">
        <location>
            <begin position="912"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="695"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1163"/>
            <end position="1217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1231"/>
            <end position="1252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="707"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1163"/>
            <end position="1173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAB0801092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="20">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1252" mass="140266" checksum="CB79250186541FA4" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AVG7</accession>
    <name>A0A5N4AVG7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PPYR_05719</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000003">
        <property type="protein sequence ID" value="KAB0801365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AVG7"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000003">
        <property type="entry name" value="Transmembrane serine protease 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252">
        <property type="entry name" value="ACROSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252:SF11">
        <property type="entry name" value="ATRIAL NATRIURETIC PEPTIDE-CONVERTING ENZYME ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="68"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="9">
        <location>
            <begin position="1068"/>
            <end position="1306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="241"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="326"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="621"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="326"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="635"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="837"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="844"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="856"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="925"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="1325"/>
            <end position="1343"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="1337"/>
            <end position="1352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0801365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1355" mass="150762" checksum="EC149929088E4F58" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AVU7</accession>
    <name>A0A5N4AVU7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PPYR_05737</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000003">
        <property type="protein sequence ID" value="KAB0801383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AVU7"/>
    <dbReference type="InParanoid" id="A0A5N4AVU7"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000034">
        <property type="entry name" value="Eupolytin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050430">
        <property type="entry name" value="Peptidase_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276:SF91">
        <property type="entry name" value="AT26814P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276">
        <property type="entry name" value="POLYSERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S1" evidence="7">
        <location>
            <begin position="33"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0801383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="261" mass="28208" checksum="03A8178F6FC062D9" modified="2020-02-26" version="1">MYPSRMMNLIVAILAFVTIFCFTYGHLIKSQRIMGGSAADMTTFSFQLSLRYENVHQCGAVLISAQTALTAAHCLYNDYNLAIQVEDLSVFGGSAYLDQGTGVNLRSVVKHSGYLPNKPFDDIAVLILQDVIGNNMVSPIALPTPNAVIEAGSKANVSGWGSLELYGDMSNLLHYVEIEVVDDNVCVDIYSTITPVTDDMVCAGSSEDGKDACYGDSGGPLTQNGMLIGIVSWGRKCGSAKYPGVYTRVDKYLDFIDSHII</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AWJ8</accession>
    <name>A0A5N4AWJ8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Cadherin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PPYR_03890</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">1611_PpyrPB1</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0801704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A5N4AWJ8">
        <property type="interactions" value="166"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AWJ8"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016342">
        <property type="term" value="C:catenin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008013">
        <property type="term" value="F:beta-catenin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045296">
        <property type="term" value="F:cadherin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060429">
        <property type="term" value="P:epithelium development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000098">
        <property type="entry name" value="cadherin-23 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000378">
        <property type="entry name" value="Cadherin-87A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000168">
        <property type="entry name" value="Cadherin-related family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000020">
        <property type="entry name" value="Dachsous cadherin-related 1b"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000026">
        <property type="entry name" value="FAT atypical cadherin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039808">
        <property type="entry name" value="Cadherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027:SF438">
        <property type="entry name" value="CADHERIN 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027">
        <property type="entry name" value="CADHERIN-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 11" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 13" id="KW-0732">Signal</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024443089" description="Cadherin domain-containing protein" evidence="13">
        <location>
            <begin position="24"/>
            <end position="1893"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1694"/>
            <end position="1718"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="14">
        <location>
            <begin position="31"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="14">
        <location>
            <begin position="135"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="14">
        <location>
            <begin position="253"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="14">
        <location>
            <begin position="361"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="14">
        <location>
            <begin position="476"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="14">
        <location>
            <begin position="590"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="14">
        <location>
            <begin position="695"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="14">
        <location>
            <begin position="799"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="14">
        <location>
            <begin position="925"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="14">
        <location>
            <begin position="1024"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="14">
        <location>
            <begin position="1132"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="14">
        <location>
            <begin position="1241"/>
            <end position="1350"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="14">
        <location>
            <begin position="1353"/>
            <end position="1471"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="14">
        <location>
            <begin position="1472"/>
            <end position="1594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00059331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAB0801704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1893" mass="210027" checksum="AAAE0BADF3EC58A0" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AXI8</accession>
    <name>A0A5N4AXI8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Regulatory protein zeste</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_04268</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in transvection phenomena (= synapsis-dependent gene expression), where the synaptic pairing of chromosomes carrying genes with which zeste interacts influences the expression of these genes. Zeste binds to DNA and stimulates transcription from a nearby promoter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Self-associates forming complexes of several hundred monomers.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AXI8"/>
    <dbReference type="InParanoid" id="A0A5N4AXI8"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028002">
        <property type="entry name" value="Myb_DNA-bind_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21411">
        <property type="entry name" value="APONTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21411:SF0">
        <property type="entry name" value="REGULATORY PROTEIN ZESTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13873">
        <property type="entry name" value="Myb_DNA-bind_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Myb/SANT-like DNA-binding" evidence="6">
        <location>
            <begin position="11"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0802082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="139" mass="16439" checksum="BE338A9A62C58F2B" modified="2020-02-26" version="1">MSVPRAKRVIFSDNDMNMLVDLVYKYKHIIECKKTDALTWKDKDATWIKISDAFNASVMEKKTPEQLRTKYDNLKKDARRYFAKQRQDIYRTGGGINKIAEMMMTKLELNDGTEANLHRFKHRRLQLASYLVTFQPQQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AXT6</accession>
    <name>A0A5N4AXT6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">sulfiredoxin</fullName>
            <ecNumber evidence="2">1.8.98.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PPYR_04166</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>S-hydroxy-S-oxy-L-cysteinyl-[peroxiredoxin] + [protein]-dithiol + ATP = S-hydroxy-L-cysteinyl-[peroxiredoxin] + [protein]-disulfide + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17545"/>
            <dbReference type="Rhea" id="RHEA-COMP:10593"/>
            <dbReference type="Rhea" id="RHEA-COMP:10594"/>
            <dbReference type="Rhea" id="RHEA-COMP:13681"/>
            <dbReference type="Rhea" id="RHEA-COMP:17976"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:61973"/>
            <dbReference type="ChEBI" id="CHEBI:61974"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="1.8.98.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfiredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.98.2" evidence="2"/>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0801980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AXT6"/>
    <dbReference type="FunCoup" id="A0A5N4AXT6">
        <property type="interactions" value="58"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AXT6"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032542">
        <property type="term" value="F:sulfiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16395">
        <property type="entry name" value="Srx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1530.10:FF:000001">
        <property type="entry name" value="Sulfiredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1530.10">
        <property type="entry name" value="Conserved hypothetical protein from pyrococcus furiosus pfu- 392566-001, ParB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036086">
        <property type="entry name" value="ParB/Sulfiredoxin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003115">
        <property type="entry name" value="ParB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016692">
        <property type="entry name" value="Sulfiredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21348">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21348:SF2">
        <property type="entry name" value="SULFIREDOXIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02195">
        <property type="entry name" value="ParB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110849">
        <property type="entry name" value="ParB/Sulfiredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ParB-like N-terminal" evidence="10">
        <location>
            <begin position="51"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0801980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="150" mass="16646" checksum="4A360B1D75ED6F69" modified="2020-02-26" version="1">MNTGEGKSAAALYTIHLLNKVNLKVWESLNIKSRRLHINKMASIHGAGIMEVHNVPMTAIIRPIMPEVNLNKVESIMGTLSNPETADLIPPIDVMWITGREGGNYYYSFGGCHRYVAHKNLNLPTIKAKLIKSTMNDLKCYLGASTPDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AYT2</accession>
    <name>A0A5N4AYT2_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Protein krueppel</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PPYR_04691</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AYT2"/>
    <dbReference type="InParanoid" id="A0A5N4AYT2"/>
    <dbReference type="OrthoDB" id="427030at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000702">
        <property type="entry name" value="Transcription factor E4F1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000478">
        <property type="entry name" value="Zinc finger protein 133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001289">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012934">
        <property type="entry name" value="Znf_AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24409:SF295">
        <property type="entry name" value="AZ2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24409">
        <property type="entry name" value="ZINC FINGER PROTEIN 142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00868">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51915">
        <property type="entry name" value="ZAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZAD" evidence="12">
        <location>
            <begin position="9"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="198"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="226"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="254"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="282"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="310"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="338"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAB0802505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="364" mass="41807" checksum="D8BACF409E830433" modified="2020-02-26" version="1">MEETYFFNKLCWVCLSEESNMISLANDRKVEIDDHSPISLYDLLKYVTNANVFYVDGPYLICNNCKLQAFAAYGFKKRCHLSYTIFQKCGLVACDGNLDRSLDVDLLPAPSEKKSTNALLDTESEEIKEECVKIEELTENLEENFFENSSVFEIIHEDVVPPSKSRNHSKVLCTICGVERSRSGIKAHMLRHNNIKNHACPFCERRFNDKGNLKVHIRIHTGVHPYVCDICGKTFIQSTGLRTHKRIHDNVKPYKCNICPYATRTSSHLQLHIKRHKGVKNYHCLHCDYSACSKAELSYHLLKHSNEKPHVCGVCGKCFARYKGLKIHQKSHTGEKPYDCQLCTKKFTQAHSLRSHLKNVHKVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AZG7</accession>
    <name>A0A5N4AZG7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Bee-milk protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PPYR_04736</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major royal jelly protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AZG7"/>
    <dbReference type="InParanoid" id="A0A5N4AZG7"/>
    <dbReference type="OrthoDB" id="7776143at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017996">
        <property type="entry name" value="MRJP/yellow-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10009">
        <property type="entry name" value="PROTEIN YELLOW-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10009:SF11">
        <property type="entry name" value="RH54244P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03022">
        <property type="entry name" value="MRJP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01366">
        <property type="entry name" value="ROYALJELLY"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024372618" description="Bee-milk protein" evidence="5">
        <location>
            <begin position="22"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0802550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="404" mass="46020" checksum="774DE0A748E21DC2" modified="2020-02-26" version="1">MTWLVLVLIFGLLALIPGSFCRGLNEEFTWTRISYAASIRLAESYIYENNIPMSANRWRNKLFVTVPRRRPGIPSTLNFIWTNTSQKHNVPLISYPNFAINQLPTGDSDGFVSIYRTAVDPCNRLWMVDTGTLEYPGNVNRLQQPAVVIIDLLTDQIIRRYELRPLDITNRTSLATMVVDVTPATCNSAYAYMPDLSGFGVVVYSFQENRSWRVSHNYFSPDAQAKDFTIGNVNFQLNDGIFSLSLSDVKPDGHRNAYFHSLAGTHTYSVSTHILKNRRLATRMDHGNDFMVEVNRGQQTQASASDLHRTSGILFLGLVNQNALACWNSFTPATPDNFDIIYKDDQKFQYPCDVKISGDDVIVITNAMPVFLFGKLNYNEINFRIWIRNVYEAIRDTKCAMRPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B0D2</accession>
    <name>A0A5N4B0D2_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MADF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_00022</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B0D2"/>
    <dbReference type="InParanoid" id="A0A5N4B0D2"/>
    <dbReference type="OrthoDB" id="9909584at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0803052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="129" mass="14848" checksum="8304FB532E17BB53" modified="2020-02-26" version="1">MKPQVTIGEMKTKFLSLKTTSLVEYRKQQRSHCSGAGEDGYTPSLWYYDKIKFVLEHQTPRQSYDSYSPDDVSSESQASIIDDDAQDTIAEEIDQTQDKDNTFRETYEIDEDETLNLLTRTPKRPAPTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B130</accession>
    <name>A0A5N4B130_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_00279</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein intermediate chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B130"/>
    <dbReference type="FunCoup" id="A0A5N4B130">
        <property type="interactions" value="857"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4B130"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045503">
        <property type="term" value="F:dynein light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010970">
        <property type="term" value="P:transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000781">
        <property type="entry name" value="Cytoplasmic dynein intermediate chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025956">
        <property type="entry name" value="DYNC1I1/DYNC1I2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050687">
        <property type="entry name" value="Dynein_IC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442:SF22">
        <property type="entry name" value="CYTOPLASMIC DYNEIN 1 INTERMEDIATE CHAIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442">
        <property type="entry name" value="DYNEIN INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11540">
        <property type="entry name" value="Dynein_IC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="491"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0803309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="672" mass="74916" checksum="E1F591F1A2EF0370" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B197</accession>
    <name>A0A5N4B197_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_00342</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B197"/>
    <dbReference type="InParanoid" id="A0A5N4B197"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF85">
        <property type="entry name" value="GH03217P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="8">
        <location>
            <begin position="162"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0803372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="369" mass="42476" checksum="C5081A89D5685A43" modified="2020-02-26" version="1">MENAFIMVISIADDMFFGSDEEDESGTVPKVVDYGEEIVPPYSDHQFKTHFRVGPAIFELLVGMVHDVVPQEVHCGRQAIPLEKQIIITLWCLANIESFRSVADRFGITKSTCWDVLYRTCKHLLRVNNVHHIISWPIGARCQRIMNEFQSVNGFPGIIGAIDECHIRIKKPQEHPNSYCNRKNYHSVLLQGVCDHSKVFLDVYAGEPGSMHDMGMFRKSDLYYRIINNEIEFPQDSHLIGDLAYKLSTTLMVGFKNLGGLTNAQMNFNYKLSQCRVDIENAFGYLKGRFRRLKYMETIRLDLMSLLIVSSCILHNLCIFNNDLPENIVMDNEVQEIRNDILHEPHVDQFEENQAIIKRTMIMNALVID</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B290</accession>
    <name>A0A5N4B290_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4806 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_00675</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B290"/>
    <dbReference type="InParanoid" id="A0A5N4B290"/>
    <dbReference type="OrthoDB" id="10069532at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032071">
        <property type="entry name" value="DUF4806"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34153:SF2">
        <property type="entry name" value="SI:CH211-262H13.3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34153">
        <property type="entry name" value="SI:CH211-262H13.3-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16064">
        <property type="entry name" value="DUF4806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4806" evidence="2">
        <location>
            <begin position="281"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="198"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0803705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="406" mass="46021" checksum="D3F36D018B4CF2F0" modified="2020-02-26" version="1">MAYVGVEFDQEERGFVAIVSDKWLTPSKQHTYWPNYTTQYDYDKSLHRGELPVIDKWQHTKLARIFFETDDYNTAQRKIKLAEELSDVATDHEQTTTNKSTTSVCEKSKRKRVAPRRLYDDVDESDCSIEEENILPKPPRISIEGRNNYNSNQILDANPESLPLRRSSSKTSKSIGSVQSNLSPQHSSTFLRDKELSTPRSTLSSRSCSSASSTITLIEEQQGSSFQSNPSTGKKRRALTDETIIDLFSFIKEQNKQILAWIQKQSNSSSESQINQNQDLPFVLPITKSADLATTETCIKEKEIFNLLVSHLSRLGGKDVTSKTNNMMRQLLSNDLATKYSFMGSRQEKKAFNDLLVKTAVVRAVQRSCTSTVVSDDQVHTAIKIWLKHAPQRLQAELKTKQKKAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B3W1</accession>
    <name>A0A5N4B3W1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein BRICK1-B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PPYR_01281</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BRK1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B3W1"/>
    <dbReference type="FunCoup" id="A0A5N4B3W1">
        <property type="interactions" value="1480"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4B3W1"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031209">
        <property type="term" value="C:SCAR complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048870">
        <property type="term" value="P:cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008064">
        <property type="term" value="P:regulation of actin polymerization or depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000017">
        <property type="entry name" value="BRICK1, SCAR/WAVE actin-nucleating complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033378">
        <property type="entry name" value="BRICK1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33668">
        <property type="entry name" value="PROTEIN BRICK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33668:SF1">
        <property type="entry name" value="PROTEIN BRICK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0804311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="76" mass="8805" checksum="724960801D7B9568" modified="2020-02-26" version="1">MSAPHREAIQKQIQQDWANREYIEVITVSIKKITDFLNSFDMSCRSKLAVLNEKLTTLERKIDYLEACVTKGETLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B494</accession>
    <name>A0A5N4B494_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase aspartic putative domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_01385</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B494"/>
    <dbReference type="InParanoid" id="A0A5N4B494"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF5">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0804415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="358" mass="41293" checksum="29E667D76B338E41" modified="2020-02-26" version="1">MKKEWENSLPTNSLPTLQEFIEFLTKRCFTLETLYNHSQTNIHNTKSIPNKQLPQFSKPFKDREHSFAITNTILCPYCKNNHYIYNCYAFLNLPTEEKFSQIRKMKLCSNCLRSGHLKNSCHSSKCRKCNKSHNTLLHDDNFNAHKFNTSHNARNDTAANIHQAQSSVMQVINSETSQQQPSESQNITRTYHSFTGICQTEVLLSTAEVFIDDRFGRPHKCRALLDSGSQSHLITQKLCNKLQLNLEEFSLHLKGINQASTNITQKATTNIKSKFYSFQARFWEVEELPQKQILTSEAQYCETYFKETTTRNAEGRFIVRLPFSDKIDELVKTSNNISLNDRLLMGPISPIYSILSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-06-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B6B2</accession>
    <name>A0A5N4B6B2_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_02112</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0805142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B6B2"/>
    <dbReference type="InParanoid" id="A0A5N4B6B2"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0805142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="98" mass="10696" checksum="D53EF393D1842DC4" modified="2020-02-26" version="1">MEEASTEEAEAADTISFQIVRGEVAVKSQEVEAPVGELAVEQIPVMTAAEPLPAEDIATTEEDTSSENVEKSETLSRRQIIRPAYLNDYVNELTLNVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B6G6</accession>
    <name>A0A5N4B6G6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein odr-4 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_01920</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ODR-4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B6G6"/>
    <dbReference type="FunCoup" id="A0A5N4B6G6">
        <property type="interactions" value="1261"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4B6G6"/>
    <dbReference type="OrthoDB" id="21458at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029454">
        <property type="entry name" value="ODR-4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33966">
        <property type="entry name" value="PROTEIN ODR-4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33966:SF1">
        <property type="entry name" value="PROTEIN ODR-4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14778">
        <property type="entry name" value="ODR4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="414"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0804950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="436" mass="49298" checksum="981C09432D5E5FAC" modified="2020-02-26" version="1">MVRGAFTDENFLKYLDTFTKLEFPTVGLMLGQRTDAKDFIIHFTRTPPYRGDAEQSIKKFADVPDSWVADHARHVTRMLPGGMYVLGLFVVCQEDIFATCVPKLKAMLSQIHKRLTPNAFLYGTPQQTEKLVLHYSQLSRYVCKSYNYDTFSLSNAEIKFQSNLAVKWLQVECKYELDQTFPIIAERANWPLKKHMNEILHLINMNLQTAVYFLDGEIKDGKECLETIGKKQKSHLRLSQLEDENKLMQVTIVLPMGGDVAPEVEILNSGGQIRLTGHVASKVWLHPKATVQYASDAIMQDIVRSLAARLEMHWDSLLEEEHGSPEDTNSVHETPRRVLINLPTTKVTLSDYLFPGEGSQEAQISLSELLDITIAQPDAIFDVEGQPDIPEMTLEGPEADCDDILASSTNRKKYIMGLVIAFVVLIISLLIHFIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B6N3</accession>
    <name>A0A5N4B6N3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase A2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_02241</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0805271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B6N3"/>
    <dbReference type="InParanoid" id="A0A5N4B6N3"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040676">
        <property type="entry name" value="DUF5641"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001995">
        <property type="entry name" value="Peptidase_A2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008042">
        <property type="entry name" value="Retrotrans_Pao"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF5">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18701">
        <property type="entry name" value="DUF5641"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05380">
        <property type="entry name" value="Peptidase_A17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50175">
        <property type="entry name" value="ASP_PROT_RETROV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase A2" evidence="3">
        <location>
            <begin position="301"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="966"/>
            <end position="991"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0805271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="991" mass="112683" checksum="48E87D43B277C379" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B6Z4</accession>
    <name>A0A5N4B6Z4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_02298</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0805328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B6Z4"/>
    <dbReference type="InParanoid" id="A0A5N4B6Z4"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009007">
        <property type="term" value="F:site-specific DNA-methyltransferase (adenine-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09275">
        <property type="entry name" value="RNase_HI_RT_DIRS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008593">
        <property type="entry name" value="Dam_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052055">
        <property type="entry name" value="Hepadnavirus_pol/RT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050:SF7">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05869">
        <property type="entry name" value="Dam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0805328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="204" mass="23667" checksum="2A1C6B9AC26AF98E" modified="2020-02-26" version="1" fragment="single">LMAVFNGISAFTPHLRNLNILIRSDNTTAISCINRMGSVSHTRLNMISRQIWDWCEERNLWISAAYVSSKENWKADAESRALLPETEWSLHQSEFEFIVSIFGNPEIDLFASKENKKCKRYISWKRNSSAEAVDAFTVPWKECFFYAFPPFSLILRTLRKIIEEEATGIVVVPFWKSQPWYPLFCKLSIDKIIHLGPNDNLLVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1K0V9</accession>
    <name>A0A1Y1K0V9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA damage-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PPYR_00801</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DDB1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01096134">
        <property type="protein sequence ID" value="JAV55134.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1K0V9"/>
    <dbReference type="FunCoup" id="A0A1Y1K0V9">
        <property type="interactions" value="2750"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1K0V9"/>
    <dbReference type="OrthoDB" id="433457at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.910:FF:000001">
        <property type="entry name" value="DNA damage-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000070">
        <property type="entry name" value="DNA damage-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000081">
        <property type="entry name" value="DNA damage-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018846">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058543">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050358">
        <property type="entry name" value="RSE1/DDB1/CFT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004871">
        <property type="entry name" value="RSE1/DDB1/CPSF1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10644">
        <property type="entry name" value="DNA REPAIR/RNA PROCESSING CPSF FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10433">
        <property type="entry name" value="Beta-prop_RSE1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23726">
        <property type="entry name" value="Beta-prop_RSE1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03178">
        <property type="entry name" value="CPSF_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RSE1/DDB1/CPSF1 first beta-propeller" evidence="5">
        <location>
            <begin position="14"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 second beta-propeller" evidence="6">
        <location>
            <begin position="396"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 C-terminal" evidence="4">
        <location>
            <begin position="798"/>
            <end position="1107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23726"/>
        </source>
    </evidence>
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                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
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                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
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                <person name="Weng J.K."/>
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                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
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        </source>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
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        <source>
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                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
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                <person name="Weng J.K."/>
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                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
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                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
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        </source>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
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                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
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                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </reference>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
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                <person name="South A."/>
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                <person name="Lewis S.M."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
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                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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                <person name="Debat H.J."/>
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                <person name="Schmitz R.J."/>
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                <person name="Oba Y."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
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    <reference evidence="11" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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    <comment type="similarity">
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
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                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
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                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
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                <person name="Sander Lower S.E."/>
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</entry>
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    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
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                <person name="Bessho-Uehara M."/>
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                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
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                <person name="Day J.C."/>
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                <person name="Shigenobu S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">1611_PpyrPB1</strain>
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        </source>
    </reference>
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        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
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                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">1611_PpyrPB1</strain>
            <tissue evidence="20">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>firefly D-luciferin + ATP + O2 = firefly oxyluciferin + hnu + AMP + CO2 + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:10732"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16792"/>
            <dbReference type="ChEBI" id="CHEBI:30212"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58038"/>
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        </reaction>
    </comment>
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            <name>Mg(2+)</name>
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        </cofactor>
    </comment>
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        <subcellularLocation>
            <location evidence="2">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="AMP-bd_C"/>
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        <property type="entry name" value="AMP-bd_C_sf"/>
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        <property type="entry name" value="AMP-binding_CS"/>
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        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
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        <property type="entry name" value="ANL_N_sf"/>
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        <property type="entry name" value="GM05240P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0455">Luminescence</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="14" id="KW-0599">Photoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="17">
        <location>
            <begin position="35"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="18">
        <location>
            <begin position="445"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="JAV71653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAB0804141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="531" mass="59215" checksum="EDFDCB17B86DA896" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LEM1</accession>
    <name>A0A1Y1LEM1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A</fullName>
            <ecNumber evidence="6">2.4.99.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">PPYR_04458</name>
    </gene>
    <organism evidence="23">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="24 25" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">1611_PpyrPB1</strain>
            <tissue evidence="24">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="24">1611_PpyrPB1</strain>
            <tissue evidence="24">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a di-trans,poly-cis-dolichyl diphosphooligosaccharide + L-asparaginyl-[protein] = N(4)-(oligosaccharide-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginyl-[protein] + a di-trans,poly-cis-dolichyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22980"/>
            <dbReference type="Rhea" id="RHEA-COMP:12804"/>
            <dbReference type="Rhea" id="RHEA-COMP:12805"/>
            <dbReference type="Rhea" id="RHEA-COMP:19506"/>
            <dbReference type="Rhea" id="RHEA-COMP:19509"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:50347"/>
            <dbReference type="ChEBI" id="CHEBI:57497"/>
            <dbReference type="ChEBI" id="CHEBI:57570"/>
            <dbReference type="ChEBI" id="CHEBI:132529"/>
            <dbReference type="EC" id="2.4.99.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="19">Component of the oligosaccharyltransferase (OST) complex. There are 2 OST complexes, OST-A and OST-B, which contain STT3A or STT3B as catalytic subunit, respectively. OST-A and OST-B contain common core subunits RPN1, RPN2, OST48, OST4, DAD1 and TMEM258, and OST-A contains DC2/OSTC and KRTCAP2/KCP2 specific accessory subunits. OST-A complex assembly occurs through the formation of 3 subcomplexes. Subcomplex 1 contains RPN1 and TMEM258, subcomplex 2 contains the OST-A-specific subunits STT3A, DC2/OSTC, and KCP2 as well as the core subunit OST4, and subcomplex 3 contains RPN2, DAD1, and OST48. The OST-A complex can form stable complexes with the Sec61 complex or with both the Sec61 and TRAP complexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the STT3 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.99.18" evidence="6"/>
    <dbReference type="EMBL" id="GEZM01062156">
        <property type="protein sequence ID" value="JAV70006.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01062155">
        <property type="protein sequence ID" value="JAV70007.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1LEM1"/>
    <dbReference type="FunCoup" id="A0A1Y1LEM1">
        <property type="interactions" value="1332"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1LEM1"/>
    <dbReference type="OrthoDB" id="10261066at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004579">
        <property type="term" value="F:dolichyl-diphosphooligosaccharide-protein glycotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043687">
        <property type="term" value="P:post-translational protein modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12610:FF:000002">
        <property type="entry name" value="dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003674">
        <property type="entry name" value="Oligo_trans_STT3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048999">
        <property type="entry name" value="STT3-PglB_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048307">
        <property type="entry name" value="STT3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13872">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13872:SF43">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT STT3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02516">
        <property type="entry name" value="STT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21436">
        <property type="entry name" value="STT3-PglB_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16" id="KW-0464">Manganese</keyword>
    <keyword evidence="14 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="144"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="173"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="195"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="271"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="301"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="363"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="389"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="413"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="454"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="Oligosaccharyl transferase STT3 N-terminal" evidence="21">
        <location>
            <begin position="21"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="STT3/PglB/AglB core" evidence="22">
        <location>
            <begin position="525"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00040922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00062993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF02516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF21436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="JAV70006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KAB0802272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="706" mass="80043" checksum="445E8EA1137C09D5" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LG07</accession>
    <name>A0A1Y1LG07_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutaminyl-peptide cyclotransferase</fullName>
            <ecNumber evidence="4">2.3.2.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PPYR_10262</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">1611_PpyrPB1</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">1611_PpyrPB1</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Acts as a glutaminyl-peptide cyclotransferase. Responsible for the biosynthesis of pyroglutamyl peptides. Might be more efficient in the conversion of tri and tetrapeptides in vitro. Might have a relative preference for substrates containing hydrophobic amino acids in vitro.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>N-terminal L-glutaminyl-[peptide] = N-terminal 5-oxo-L-prolyl-[peptide] + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:23652"/>
            <dbReference type="Rhea" id="RHEA-COMP:11736"/>
            <dbReference type="Rhea" id="RHEA-COMP:11846"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:64722"/>
            <dbReference type="ChEBI" id="CHEBI:87215"/>
            <dbReference type="EC" id="2.3.2.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glutaminyl-peptide cyclotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.5" evidence="4"/>
    <dbReference type="EMBL" id="GEZM01058203">
        <property type="protein sequence ID" value="JAV71798.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1LG07"/>
    <dbReference type="FunCoup" id="A0A1Y1LG07">
        <property type="interactions" value="567"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1LG07"/>
    <dbReference type="OrthoDB" id="3907302at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016603">
        <property type="term" value="F:glutaminyl-peptide cyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03880">
        <property type="entry name" value="M28_QC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000029">
        <property type="entry name" value="Glutaminyl-peptide cyclotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037457">
        <property type="entry name" value="M28_QC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040234">
        <property type="entry name" value="QC/QCL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12283">
        <property type="entry name" value="GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12283:SF6">
        <property type="entry name" value="GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033291753" description="Glutaminyl-peptide cyclotransferase" evidence="13">
        <location>
            <begin position="22"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="14">
        <location>
            <begin position="103"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00057903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="JAV71798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAB0796201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="351" mass="40431" checksum="B2EFB965C5AE2107" modified="2017-08-30" version="1">MNIINVLTLNILVFVFKFSAAAKGTSSRQTLNDRQVHYLSDLTDTQYTKETFKHLLVPRVVGTEGHKNVAKYIINELDKLGYEIEVDEFQERTPIFGTLTFKNIVARLNPNAAKFISLACHYDSKYFEEFDFIGATDSAVPCAMMLNLAKVLRKELDNAKNRTDISLKLVFFDGEEAFEQWGPNDSIYGAKHLAEKWDQTLRNTADGASVSHIESIELLVLLDLLGARNPRFYSFFENTRSWYNVLSNAEKQLASLGLLTGYKQPYFVDRSQYSFIEDDHIPFYHRGVKILHIIPTPFPFVWHRREDDASAIDLNVVENLNKIFRIFVARSLHLFGDDLKQETVQEKKEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LJC3</accession>
    <name>A0A1Y1LJC3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Chitin-binding type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PPYR_06137</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01057072">
        <property type="protein sequence ID" value="JAV72460.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000004">
        <property type="protein sequence ID" value="KAB0800397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1LJC3"/>
    <dbReference type="FunCoup" id="A0A1Y1LJC3">
        <property type="interactions" value="30"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1LJC3"/>
    <dbReference type="OrthoDB" id="439917at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.140.10:FF:000002">
        <property type="entry name" value="Gasp, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051940">
        <property type="entry name" value="Chitin_bind-dev_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301:SF104">
        <property type="entry name" value="BCDNA.GH02976"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301">
        <property type="entry name" value="CHITIN BINDING PERITROPHIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036312548" description="Chitin-binding type-2 domain-containing protein" evidence="7">
        <location>
            <begin position="20"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="8">
        <location>
            <begin position="37"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="8">
        <location>
            <begin position="105"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="8">
        <location>
            <begin position="170"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="243"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="JAV72460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0800397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="277" mass="31787" checksum="34AA86DAA709613A" modified="2017-08-30" version="1">MARVLNLLMLLLTAGTVFAARNKQSRPAEKDFEQESSDQCPEPYGYFADVEQCDKYYECKDGQITEKLCPDGMVFNDFSTQDEKCDLPFNIDCTTRPKLQTPQPSQNCPRKHGYFAHEEANVCDKFYYCTDGKFNLIVCPDGLVYNEKVGICSWPDEAKKKGCSSRDVFQFDCPKVNESVGLTHPRYPDPEDCQYFYVCIDGVTPRRNGCKLGQAFDERTSKCDWARKIPECADWYKDRLTDEQLDALENPPTPRPRPTGPINRRKPARKPVVHEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LPH0</accession>
    <name>A0A1Y1LPH0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein Wnt</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PPYR_01628</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Ligand for members of the frizzled family of seven transmembrane receptors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Secreted</location>
            <location evidence="1 9">Extracellular space</location>
            <location evidence="1 9">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Wnt family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01054656">
        <property type="protein sequence ID" value="JAV73506.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1LPH0"/>
    <dbReference type="InParanoid" id="A0A1Y1LPH0"/>
    <dbReference type="OrthoDB" id="5945655at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005109">
        <property type="term" value="F:frizzled binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045165">
        <property type="term" value="P:cell fate commitment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060560">
        <property type="term" value="P:developmental growth involved in morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007517">
        <property type="term" value="P:muscle organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19338">
        <property type="entry name" value="Wnt_Wnt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2460.20:FF:000001">
        <property type="entry name" value="Wnt homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2460.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005817">
        <property type="entry name" value="Wnt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009143">
        <property type="entry name" value="Wnt6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043158">
        <property type="entry name" value="Wnt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018161">
        <property type="entry name" value="Wnt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12027:SF99">
        <property type="entry name" value="PROTEIN WNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12027">
        <property type="entry name" value="WNT RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00110">
        <property type="entry name" value="wnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01349">
        <property type="entry name" value="WNTPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00097">
        <property type="entry name" value="WNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00246">
        <property type="entry name" value="WNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="6 9" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033289707" description="Protein Wnt" evidence="10">
        <location>
            <begin position="25"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="JAV73506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAB0804658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="355" mass="40829" checksum="09934E762BBBC927" modified="2017-08-30" version="1">MKRRGAGRLAAVALWTLLLHLTHADWWQLGLPSSLSNSVDLTPTSHKDRCHKLEYLVDRQRELCAQNDRVLSIIGNGAKLAMDECQHQFRNSRWNCSTFPEYNSVFGNVVSVKSRESAYIYAISAASVAFAITRACSKGELTDCSCDNRVRQRKGRFWQWGGCSEDIQYGEQFSRDFLDSREDANTPSGLMNLHNNEAGRRNIRQRMQRVCKCHGMSGSCSMRVCWRRLPPLRQVGEALFQRYEGASHVKFVERRRKKLKVISPDLKKPNKTDLVYLEDSPDYCERNETLNVLGTKGRICNTTSHGIDGCRLLCCGRGYQTRVREVEEKCKCQFVWCCNVVCEMCRYKKEEHICN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LQ27</accession>
    <name>A0A1Y1LQ27_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_05741</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01049871">
        <property type="protein sequence ID" value="JAV75794.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01049870">
        <property type="protein sequence ID" value="JAV75795.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01049869">
        <property type="protein sequence ID" value="JAV75796.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000003">
        <property type="protein sequence ID" value="KAB0801387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1LQ27"/>
    <dbReference type="FunCoup" id="A0A1Y1LQ27">
        <property type="interactions" value="1258"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1LQ27"/>
    <dbReference type="OrthoDB" id="5632at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14500">
        <property type="entry name" value="PTP-IVa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000081">
        <property type="entry name" value="Tyrosine phosphatase type IVA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050561">
        <property type="entry name" value="PTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23339">
        <property type="entry name" value="TYROSINE SPECIFIC PROTEIN PHOSPHATASE AND DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22785">
        <property type="entry name" value="Tc-R-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="2">
        <location>
            <begin position="83"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="JAV75794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0801387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="172" mass="19510" checksum="2FE5C20874059C36" modified="2017-08-30" version="1">MRQKDIRPAPAEIQYKGFKFLITDRPSDQSILTYIQELKKHNVSAVVRVCEPSYKTDDLNSIGIEVIDLVYDDGTFPPSEVVDEWFKLLKNQLHENPDACVAVHCVSGLGRAPVMVALALIELGLKYEEAVELIREKRRGAINAKQLGFLEKYRPKSRLKLKNGHKNSCCVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LRT9</accession>
    <name>A0A1Y1LRT9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Membrane insertase YidC/Oxa/ALB C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PPYR_14058</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Membrane</location>
            <topology evidence="1 5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the OXA1/ALB3/YidC family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01048828">
        <property type="protein sequence ID" value="JAV76372.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1LRT9"/>
    <dbReference type="FunCoup" id="A0A1Y1LRT9">
        <property type="interactions" value="654"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1LRT9"/>
    <dbReference type="OrthoDB" id="2148490at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032977">
        <property type="term" value="F:membrane insertase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032979">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane from matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20069">
        <property type="entry name" value="5TM_Oxa1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001708">
        <property type="entry name" value="YidC/ALB3/OXA1/COX18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028055">
        <property type="entry name" value="YidC/Oxa/ALB_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428:SF65">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX18, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428">
        <property type="entry name" value="OXA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02096">
        <property type="entry name" value="60KD_IMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Membrane insertase YidC/Oxa/ALB C-terminal" evidence="6">
        <location>
            <begin position="69"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="JAV76372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0792097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="325" mass="37252" checksum="91CFCC1BD52CB240" modified="2017-08-30" version="1">MYSVLLKRPAYALPRFYKLTRNERRFSLNSITDALRVQSGIFRIISESAPVECLQKFVINVHDVTGLPWWATIVCTTFFLRSTVTVPLALYQNFVMAKVQNAQAELIELSKELKREVAVAVKLYDWDQKTAAYNFKRSLKKQWKALIERDNCHPAKASLLIWFQLPLWVCFSVALRNLAYQLPHSHVNAELVHHDLSVEGFGWIVNLTQVDPYFVLPLSFGLINLTIIEIQAASRRGSPSKFQRFVLNFFRGVTIVMVPVAAGVPSCITLYWTTSSLYGFVQNLVLMSPKLKRWCRIPKTPNDIDKPYSHVIKGIKNKFVVSKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LSU7</accession>
    <name>A0A1Y1LSU7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PPYR_05474</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="20 21" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">1611_PpyrPB1</strain>
            <tissue evidence="20">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">1611_PpyrPB1</strain>
            <tissue evidence="20">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01051892">
        <property type="protein sequence ID" value="JAV74646.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000003">
        <property type="protein sequence ID" value="KAB0801120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1LSU7"/>
    <dbReference type="FunCoup" id="A0A1Y1LSU7">
        <property type="interactions" value="642"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1LSU7"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042562">
        <property type="term" value="F:hormone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006898">
        <property type="term" value="P:receptor-mediated endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000105">
        <property type="entry name" value="Lipophorin receptor 1, isoform K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000009">
        <property type="entry name" value="Low-density lipoprotein receptor isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000002">
        <property type="entry name" value="low-density lipoprotein receptor isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000004">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000015">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000113">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000030">
        <property type="entry name" value="Sortilin related receptor 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051221">
        <property type="entry name" value="LDLR-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000033">
        <property type="entry name" value="LDLR_classB_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22722">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22722:SF14">
        <property type="entry name" value="MEGALIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14670">
        <property type="entry name" value="FXa_inhibition"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00058">
        <property type="entry name" value="Ldl_recept_b"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00135">
        <property type="entry name" value="LY"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51120">
        <property type="entry name" value="LDLRB"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11 14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="6" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="17" id="KW-0732">Signal</keyword>
    <keyword evidence="7 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033289727" description="EGF-like domain-containing protein" evidence="17">
        <location>
            <begin position="26"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="807"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="18">
        <location>
            <begin position="388"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="15">
        <location>
            <begin position="490"/>
            <end position="533"/>
        </location>
    </feature>
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        <location>
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        </location>
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        <location>
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            <end position="184"/>
        </location>
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        <location>
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        </location>
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        <location>
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        </location>
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        </location>
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        <location>
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        <location>
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        </location>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS01186"/>
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            <dbReference type="EMBL" id="JAV74646.1"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAB0801120.1"/>
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            <dbReference type="Proteomes" id="UP000327044"/>
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    </evidence>
    <sequence length="889" mass="99571" checksum="2552CA29322497A9" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
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    <organism evidence="2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
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            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
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    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
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        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
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                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">1611_PpyrPB1</strain>
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        </source>
    </reference>
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        <source>
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    <sequence length="352" mass="39672" checksum="30215C42A27645B8" modified="2017-08-30" version="1">MDASNKTHWGEIPNQETNSNDDSFFPDVRADIERSMNRFCLAEFDSDYHDERFQSEEVSLDSMDPLIMYAITLHKHMNEMVRVAELAIESDLIPPADVIPPIPPMPEVQKKHTRNCLNFIPKEFTQFSLGEAELSPEISSTIVKQILTKSVATMFAHIGYETTSASVLNVLVDVLSAFLKKIIYHLKLAQEDKENGKLDEFPNIVERVLVELGMGGVKGLHDYYQTRVIKYIDVLQRRCKELNKHYEGLLVRQTPSPDSKENKVIRVHVEEEEDVIEIDNPQVHLAIDGEVGFSTLDAGYQLLSSLEAGTSSQGLVENEEDTSITISPGVVSIPETELVTALSPFIKKKRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LVM3</accession>
    <name>A0A1Y1LVM3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GTPase Era, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ERA-like protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_13482</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
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            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
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            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.</text>
    </comment>
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        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01045907">
        <property type="protein sequence ID" value="JAV77629.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KAB0793862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <dbReference type="OrthoDB" id="8954335at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="F:ribosomal small subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002220">
        <property type="entry name" value="GTPase Era, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030388">
        <property type="entry name" value="G_ERA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005662">
        <property type="entry name" value="GTPase_Era-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42698">
        <property type="entry name" value="GTPASE ERA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42698:SF1">
        <property type="entry name" value="GTPASE ERA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Prokaryotic type KH domain (KH-domain type II)"/>
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    </dbReference>
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        <property type="entry name" value="G_ERA"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4 6" id="KW-0342">GTP-binding</keyword>
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        <location>
            <begin position="42"/>
            <end position="239"/>
        </location>
    </feature>
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            <begin position="50"/>
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        </location>
    </feature>
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        </location>
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        </location>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="217"/>
            <end position="219"/>
        </location>
    </feature>
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        <location>
            <position position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030975"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01050"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="JAV77629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0793862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="349" mass="39991" checksum="7767826829156EBC" modified="2017-08-30" version="1" fragment="single">MNCFKLSKIHFRLYISKEIIRKCNTLQNSAYKEHENSHESQSLVKVAVIGMPNAGKSTFINYLMDRKVCPTSSKVHTTRTKASAIFTHGNTQIVFLDTPGLVNNNVRRRHNLENSFIKDSNISLQQCDLISVIHDVSNSWTRNTLDIKILRLLEQHQNKESFLVLNKVDVLKSKRKLLDIVRLLTHNSLAGKPIGKNEEPLDIEKKGWPNFKDIFMVSALTGTGLNELKQYLIRAAKPGKWLYPEEMFTDQSPEKIIENTVKATLLDFLPQEIPYQMKPQIELYEVNDGIINTVVIIKCVSDRVAKLVAGLGDGRLRQITESTQRNLQSVFQHFVRIRIVLESKEKKIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1MHB0</accession>
    <name>A0A1Y1MHB0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PPYR_05271</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
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    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.</text>
    </comment>
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        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="OrthoDB" id="3257095at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Y+L amino acid transporter 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Amino acid/polyamine transporter I"/>
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    </dbReference>
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        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
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    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
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        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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            <end position="86"/>
        </location>
    </feature>
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        <location>
            <begin position="113"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <end position="325"/>
        </location>
    </feature>
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        <location>
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            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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        </location>
    </feature>
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        <location>
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            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00007040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="JAV82697.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAB0800917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="486" mass="53585" checksum="D450339759EA78E0" modified="2017-08-30" version="1">MSSFDNIKSEHLAELETEDDLQTGKIRLKKELGLLEGVAVILGIIFGSGIFISPKGIIQEVESIGFSLVVWVLCGLLSMIGAICYAELGTTVPKSGGDYAYINEAFGPLPAFLYLWAANLIFVPTTNAIMGLTFANYVIQPFFPNCSIPNVAVMLLATITISSLSYLNGYNVKATTKIQNVFMFCKVGALIVVILVGVTWMCMGHVEHFDEPFEGTITNPGKIAKAFYSGIFSYSGWNYLNFMTEELKNPYVNLPRAIFISIPLVTAIYVLANMSYLAVLTPDAMKASDAIAVTFGNRVMGKVAWIIPVMVAISAFGGLSVHIMASSRMLFVGARNGHFPAFLSHLSITRFTPVASLVFLNVLSLLMLGIGSIHKLITYCTIVESFFVMLSVMGLLYMRWKRPKLERPIKVWIGVPIIFVMLCFFLIVMPCVEAPYEVGMGVLITLSGIPAYYLGVCWTNKPLWFQTIMRKVTKVCQIIFIAAKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1MTS8</accession>
    <name>A0A1Y1MTS8_PHOPY</name>
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        <recommendedName>
            <fullName evidence="13">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="15" type="ORF">PPYR_12959</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">1611_PpyrPB1</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">1611_PpyrPB1</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GEZM01023093">
        <property type="protein sequence ID" value="JAV88588.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1MTS8"/>
    <dbReference type="InParanoid" id="A0A1Y1MTS8"/>
    <dbReference type="OrthoDB" id="9451254at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048619">
        <property type="term" value="P:embryonic hindgut morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016348">
        <property type="term" value="P:imaginal disc-derived leg joint morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007366">
        <property type="term" value="P:periodic partitioning by pair rule gene"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000958">
        <property type="entry name" value="Odd skipped"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002020">
        <property type="entry name" value="Odd skipped"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000254">
        <property type="entry name" value="Odd-skipped related transciption factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000311">
        <property type="entry name" value="protein odd-skipped-related 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Classic Zinc Finger"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF00096">
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    </dbReference>
    <dbReference type="Pfam" id="PF13912">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
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        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
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    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="127"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="155"/>
            <end position="182"/>
        </location>
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    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="183"/>
            <end position="210"/>
        </location>
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    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="211"/>
            <end position="238"/>
        </location>
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    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="238"/>
            <end position="265"/>
        </location>
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            <begin position="1"/>
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            <end position="311"/>
        </location>
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
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        <source>
            <dbReference type="EMBL" id="JAV88588.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAB0793339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="311" mass="35765" checksum="86D24A7DDDB6A531" modified="2017-08-30" version="1">MSAASDYINSDAIVKGHQGYPPPPYQEIKIEATHTSPLLTPPHTPTYSTSPPPRYPCEPWFQEPQRYQYQSQPPPVPYPSYNAVLVNQWLRNAALYHARSQVDLRAPGRAPMPMKMGPGSSRPKKQFICKFCNRQFTKSYNLLIHERTHTDERPYSCDICGKAFRRQDHLRDHRYIHSKEKPFKCGECGKGFCQSRTLAVHKILHLEESPHKCPVCNRSFNQRSNLKTHLLTHTERPLECSMCSQFFTSYAELRAHEIQHSTTSNPSVDTNSCLDLSTKRYSSVQRLPNTTDKDGSTRKPLGFSIEDIMKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1MUR8</accession>
    <name>A0A1Y1MUR8_PHOPY</name>
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        <recommendedName>
            <fullName evidence="5">Carboxylesterase type B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_06607</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
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        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
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    </dbReference>
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    </dbReference>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="JAV89433.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAB0798727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="529" mass="59647" checksum="CBDD8D5047F8785C" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1MXZ0</accession>
    <name>A0A1Y1MXZ0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Group XV phospholipase A2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_09278</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01017645">
        <property type="protein sequence ID" value="JAV90524.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01017642">
        <property type="protein sequence ID" value="JAV90527.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01017640">
        <property type="protein sequence ID" value="JAV90529.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01017633">
        <property type="protein sequence ID" value="JAV90532.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1MXZ0"/>
    <dbReference type="FunCoup" id="A0A1Y1MXZ0">
        <property type="interactions" value="180"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1MXZ0"/>
    <dbReference type="OrthoDB" id="190846at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003386">
        <property type="entry name" value="LACT/PDAT_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11440">
        <property type="entry name" value="LECITHIN-CHOLESTEROL ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02450">
        <property type="entry name" value="LCAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011907530" description="Group XV phospholipase A2" evidence="1">
        <location>
            <begin position="21"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="JAV90524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0798285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="401" mass="45199" checksum="1DF229E9937A5C4C" modified="2017-08-30" version="1">MRLIHTSVIVLSLIFSSASGGGLNPVVFIPGDGGSQLEAKLNKSAVVHYLCQKTTSSYFNIWLNLELLTPVIIDCWIDNVKLKYDNVTRKTSNMDGVDIRVTGFGNTESVEYLDPSHASSGYYFKDIGNALVNLGYVRNLSVRGAPFDFRKAPNENQDYFIQLRELIEATYTANNNTPIILIAHSMGGPMSIYFLSIQSSAWKAKYIKSLVSLSGAWGGTVKAVKVYTIGDNLGSYFLRESVMRQEQITSPSLAWLLPSPYFWHQDETLVQTEHKNYSLRNLQEYFKDIQFMDGWEMKKDTDPFRINITAPGVEVHCLYGINVPTVEKLYYKPGAWLDGYPVLINGDGDGTVNRRSLEGCMLWQRMQKQPVHVVPMRNVDHMQILNSGSVISYITNLMKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1N1X8</accession>
    <name>A0A1Y1N1X8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Catalase</fullName>
            <ecNumber evidence="11">1.11.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PPYR_10010</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">1611_PpyrPB1</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">1611_PpyrPB1</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the degradation of hydrogen peroxide (H(2)O(2)) generated by peroxisomal oxidases to water and oxygen, thereby protecting cells from the toxic effects of hydrogen peroxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 11">
            <text>2 H2O2 = O2 + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the catalase family.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.6" evidence="11"/>
    <dbReference type="EMBL" id="GEZM01015046">
        <property type="protein sequence ID" value="JAV91911.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0795949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1N1X8"/>
    <dbReference type="FunCoup" id="A0A1Y1N1X8">
        <property type="interactions" value="1312"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1N1X8"/>
    <dbReference type="OrthoDB" id="6880011at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042542">
        <property type="term" value="P:response to hydrogen peroxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08156">
        <property type="entry name" value="catalase_clade_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.180.10:FF:000001">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.180.10">
        <property type="entry name" value="Catalase core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040333">
        <property type="entry name" value="Catalase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024708">
        <property type="entry name" value="Catalase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024711">
        <property type="entry name" value="Catalase_clade1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002226">
        <property type="entry name" value="Catalase_haem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010582">
        <property type="entry name" value="Catalase_immune_responsive"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465">
        <property type="entry name" value="CATALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465:SF9">
        <property type="entry name" value="CATALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06628">
        <property type="entry name" value="Catalase-rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038928">
        <property type="entry name" value="Catalase_clade1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00067">
        <property type="entry name" value="CATALASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="Heme-dependent catalase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00437">
        <property type="entry name" value="CATALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00438">
        <property type="entry name" value="CATALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10 11" id="KW-0349">Heme</keyword>
    <keyword evidence="7 11" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="6 10 11" id="KW-0408">Iron</keyword>
    <keyword evidence="4 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 11" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catalase core" evidence="14">
        <location>
            <begin position="69"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="427"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="10">
        <location>
            <position position="398"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR038928-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR038928-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="JAV91911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAB0795949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="546" mass="61620" checksum="9F9FDF7CC18B32FE" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1N3A5</accession>
    <name>A0A1Y1N3A5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">SAGA-associated factor 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PPYR_02926</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates histone H2B. The SAGA complex is recruited to specific gene promoters by activators, where it is required for transcription.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of some SAGA transcription coactivator-HAT complexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the SGF11 family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01018751">
        <property type="protein sequence ID" value="JAV90037.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01018749">
        <property type="protein sequence ID" value="JAV90038.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01018748">
        <property type="protein sequence ID" value="JAV90039.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1N3A5"/>
    <dbReference type="FunCoup" id="A0A1Y1N3A5">
        <property type="interactions" value="190"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1N3A5"/>
    <dbReference type="OrthoDB" id="21557at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071819">
        <property type="term" value="C:DUBm complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAB0791126.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="243" mass="27567" checksum="B0B7DF280A379C08" modified="2017-08-30" version="1">MAFHRHPTTEDYYKEFKRLQSNKELLKKATEEFLDKLIDHVIIGVAFQVHRNKKLKVIELDEVVVKQEGPRPCVDIFGPYNFKKKYECLCRNCDRVVGASVFAPHLEVCMGMGRSRSRNASRRIANNSRERENSTYSSGVPSDDEDDMDWGSGDKRKKKKDRNGNKKLKGNSKKSTDLNDSAESINIDVEGEADDILNLRDLMQDLSRGPSPADSVSSSGSTKRRDKSKNKKRKERVSPNSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Photinus pyralis</name>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
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                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
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            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
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            <dbReference type="PubMed" id="30324905"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="11">1611_PpyrPB1</strain>
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    <reference evidence="11" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
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                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
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            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
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</entry>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
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                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
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            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </comment>
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</entry>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
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            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
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        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01002435">
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        <property type="molecule type" value="Transcribed_RNA"/>
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        <property type="protein sequence ID" value="KAB0790938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="6575879at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:phosphatidylinositol bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1200">
        <property type="entry name" value="Alpha-tocopherol transfer"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174">
        <property type="entry name" value="ALPHA-TOCOPHEROL TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174:SF222">
        <property type="entry name" value="GH10083P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00180">
        <property type="entry name" value="CRETINALDHBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="158"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="JAV97261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0790938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="306" mass="35964" checksum="B178C7C641B8954A" modified="2017-08-30" version="1">MSSFDLLKCTPEERKCILAKYDKTPENIREDVQTVKNWIKSQPHLPEVPEDGLIERFLLLNKFRIEIAKRKIDGYYSIRSLIPEFYDKDPNGEVIRELTKMIYYIPLPKLTEEHYRVVIVKPRKPITESIDAVTYMAHSLNMAELRVRHDYYHREAHIYDLEGVRITNMTKFTPSLIKKIGLVLEKVFTNSIGGLHFINVPNFVDSFIILLKNTLQPKVASRVNVHKGTESLYDMFSKDILPKDYGGTEMSLDELSEEWMKFFQNHVDLFEKLSKMRVNEELRQKPLFDEDELFGIQGNFKQLNVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N3ZYA7</accession>
    <name>A0A5N3ZYA7_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_15643</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01002028">
        <property type="protein sequence ID" value="KAB0790038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N3ZYA7"/>
    <dbReference type="InParanoid" id="A0A5N3ZYA7"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34239">
        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34239:SF2">
        <property type="entry name" value="TRANSPOSABLE ELEMENT P TRANSPOSASE_THAP9 CONSERVED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0790038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="333" mass="37063" checksum="1D829AFC2ADAEE2A" modified="2020-02-26" version="1">MQLVICILLGAGRRSSTPTDPSIIYANTPSLSDRSDVSLPEEDGHRHFKDLWRASPSDDDVPGLSAPLQPGVPFRDVNPTVQIVADVASTEQEDLLSLLGNETTPDVTFGLPIHERIANNLNFILRSGLKTEDLNRLLSKYPIPENCRAFKSPELNAIVQHSLCDKFVQRDKKLANLQSRIGTAMAASANCLNKLLEIKNIDKGLIESLNDALKILSDVHFNESQVRRSLIRSNINDSLRLTLDNNGIDDFLFGSDLEEKVKATKHLEKASRDLSLTKPKPSNTKSKNGQNPLAFNRFRYRGRGASRPQNASGTKRLMANRVPYGKKPFQFRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2024-01-24" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N3ZYS7</accession>
    <name>A0A5N3ZYS7_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_15456</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the C19orf12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01001675">
        <property type="protein sequence ID" value="KAB0790210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N3ZYS7"/>
    <dbReference type="InParanoid" id="A0A5N3ZYS7"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033369">
        <property type="entry name" value="C19orf12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31493">
        <property type="entry name" value="NAZO FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31493:SF1">
        <property type="entry name" value="PROTEIN C19ORF12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20721">
        <property type="entry name" value="C19orf12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0790210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="140" mass="15151" checksum="AED7D3EEA35E6D7E" modified="2020-02-26" version="1">MPLNQRELINVVVKLAEHKNLRVTIKESAKAGAIAGGSALIGGLLGGPIGIAIGGTIGSVFAAATAKEFKSVAAIILEDMTPRQRQQFVSTIRRALQQYSWMDVYELQRILRENQSVEILLLAAISNFFKDVMGHTISMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A0B8</accession>
    <name>A0A5N4A0B8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_15551</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000793">
        <property type="protein sequence ID" value="KAB0790761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A0B8"/>
    <dbReference type="InParanoid" id="A0A5N4A0B8"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33939:SF1">
        <property type="entry name" value="DUF4371 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33939">
        <property type="entry name" value="PROTEIN CBG22215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0790761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="314" mass="36121" checksum="24E2696F633B9D79" modified="2020-02-26" version="1" fragment="single">KNHGGVGTYFSNGSSTKNSGCGASIETNSCEDMCYARDCGSDLKRNPYRRSKPRRTDLLENKKHTIRYLIYDMYANKEHVTLDTLLAVIKLKDLCDLGRTSLFYALKEMGFKFKMTNSRRGSCEQSHVVSMRNVFLRKYIRNLESEVPHDFVFLEETWVFSRGATKHGKRYIIIHAGGRNGFTDGSSLIFSSTNKSFDYHDNMNAELVEKRFEESFLKKLAQPSIIVLDNASYHTRKSEKIPTASSTKEEISNWLKMKNRPFDVWNRCVTHTEEIIKDTFNREKIIDDVRALVFTVNTGSDEESDYLSESDNDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A0C7</accession>
    <name>A0A5N4A0C7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable oligoribonuclease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_15352</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oligoribonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000765">
        <property type="protein sequence ID" value="KAB0790777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A0C7"/>
    <dbReference type="FunCoup" id="A0A5N4A0C7">
        <property type="interactions" value="2229"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A0C7"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06135">
        <property type="entry name" value="Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000003">
        <property type="entry name" value="Oligoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022894">
        <property type="entry name" value="Oligoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003765">
        <property type="entry name" value="PRK05359.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11046">
        <property type="entry name" value="OLIGORIBONUCLEASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11046:SF0">
        <property type="entry name" value="OLIGORIBONUCLEASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="6">
        <location>
            <begin position="1"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00072681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0790777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="168" mass="19435" checksum="915551D41BE54402" modified="2020-02-26" version="1">MTGLDIEKDRIMEIACIVTDGNLNVVAEGPNVILNVPKDILENMNGWCLKQHNKTGLTESSLNSKITAEIAETELLNFISNHVVEKCSPLAGNSVYMDRLFLRKFMPRVDSYLHYRIVDVSSIKELCRIWNRDVYKNAPTKTLEHRALQDIRESIQELQFYRMNFFNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A111</accession>
    <name>A0A5N4A111_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_02812</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A111"/>
    <dbReference type="InParanoid" id="A0A5N4A111"/>
    <dbReference type="OrthoDB" id="8300214at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="1">
        <location>
            <begin position="56"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0791012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="224" mass="26081" checksum="F8DD32F1BD22DCBA" modified="2020-02-26" version="1">MWNRQRNARCSSTRVTSINEGSYRDRQGEYPGGGGKLRFENVDIVHGKNFVDAHLKYFDHIFSFSCLHFVREQGTALQHIREMLRPGGDFSFFCVNSNSFFKVVAHLAQSESWRLHIAHYENFMSPYQFSQNPMDELEDLLIKTGFQIRSLTIEPRGVEMPLSYCPGHFIAHLRMEIPADLHHEFGLSVLETIRELNLSRLAEDNVEYYDDYFDGIFGHVIRPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A137</accession>
    <name>A0A5N4A137_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">sn-1-specific diacylglycerol lipase ABHD11</fullName>
            <ecNumber evidence="3">3.1.1.116</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Alpha/beta hydrolase domain-containing protein 11</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PPYR_02844</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>1,2-didecanoylglycerol + H2O = decanoylglycerol + decanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48596"/>
            <dbReference type="ChEBI" id="CHEBI:11152"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:27689"/>
            <dbReference type="ChEBI" id="CHEBI:90605"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + H2O = 2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-glycerol + octadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:77107"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:25629"/>
            <dbReference type="ChEBI" id="CHEBI:77129"/>
            <dbReference type="ChEBI" id="CHEBI:186738"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + H2O = 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + octadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38507"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:25629"/>
            <dbReference type="ChEBI" id="CHEBI:52392"/>
            <dbReference type="ChEBI" id="CHEBI:75728"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + H2O = 2-(9Z-octadecenoyl)-glycerol + octadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:77103"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:25629"/>
            <dbReference type="ChEBI" id="CHEBI:73990"/>
            <dbReference type="ChEBI" id="CHEBI:75468"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 1,2-diacyl-sn-glycerol + H2O = a 2-acylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33275"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17389"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.116"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 1,3-diacyl-sn-glycerol + H2O = a 1-acyl-sn-glycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38503"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:64683"/>
            <dbReference type="ChEBI" id="CHEBI:77272"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.116" evidence="3"/>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A137"/>
    <dbReference type="FunCoup" id="A0A5N4A137">
        <property type="interactions" value="1393"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A137"/>
    <dbReference type="OrthoDB" id="8119704at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46118">
        <property type="entry name" value="PROTEIN ABHD11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46118:SF4">
        <property type="entry name" value="PROTEIN ABHD11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="12">
        <location>
            <begin position="43"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00026104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00042703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00043667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00043742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAB0791044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="300" mass="33667" checksum="BF707BCE4F807FB2" modified="2020-02-26" version="1">MAVAHTKLVQIFRLFFKQISTRSDETIEMSFDVFNDVKETTAPVLVMHGLLGARTNWRSLCALLRKQTDPPRAVISVDARNHGASPQSSEHTYPLMAEDIKRFVSKLGIKRSTLIGHCMGGRAMMYFALKYPDFVEKLVIVDVSPVGPSPFLKLVPGLLEAIAAIPLPKDASIIEAKRDLKRMLLKSITNKAYVNFIVDTNLMKDNHGSLRWRFNTQVLLESFASSLAVFPNMSPLRFEKPALFVSGGLSNFVLKSHHAEILKLFPQAEFRVIEGAGHIVHVEKPKEFLAVCLNFLNKHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A206</accession>
    <name>A0A5N4A206_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nose resistant-to-fluoxetine protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_03119</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A206"/>
    <dbReference type="InParanoid" id="A0A5N4A206"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006621">
        <property type="entry name" value="Nose-resist-to-fluoxetine_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052728">
        <property type="entry name" value="O2_lipid_transport_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161">
        <property type="entry name" value="O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161:SF0">
        <property type="entry name" value="O-ACYLTRANSFERASE LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20146">
        <property type="entry name" value="NRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00703">
        <property type="entry name" value="NRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="350"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="388"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="447"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="Nose resistant-to-fluoxetine protein N-terminal" evidence="2">
        <location>
            <begin position="124"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0791319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="483" mass="54942" checksum="8D2D3671450AE9D7" modified="2020-02-26" version="1">MEKPKRKVRVRPRREWMDQIRERGTERGKTAGKMKILGRDRKKWRNWIQDKKPTSDDKEEEEFLIQKTNPQYATMAPQKLLCLILLVAGTKGDVFDYNFEALSSPRMLSDALESFLLRNATAVSWNCSAQLSEYVDGLRSREEWALTMYDSTGKLPAGVLDGNLAELGSFDECLYVTKLNEEPEGSSFTGQYCLGSIYVNATRNISAEILFGVFANKLAFSTCLPDACSDTDVQTIIRGIGINFTTEDPHCQTLAKRPELDTGGIIGLTITVCLALLMVASTIYDIRNKFTGKRAPNRLLSAFSIYTNLKNIFNTKSAFGEITCLHGVRSIAMFIWIYQIQNMPLLKADLAMDVFLFLSGSMIAYGYFQKMAKQQRFGIILHYVNRYLRLTPSLAAVVLFAATMVKYLGSGPLWPAFNEGILDPCVQNWWYNMLYIQTFLEKRCLTYTWYSAVDFQLFLLSPLLLIPHNRISRSIYVIAYNCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A295</accession>
    <name>A0A5N4A295_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Fatty acyl-CoA reductase</fullName>
            <ecNumber evidence="10">1.2.1.84</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PPYR_03232</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>a long-chain fatty acyl-CoA + 2 NADPH + 2 H(+) = a long-chain primary fatty alcohol + 2 NADP(+) + CoA</text>
            <dbReference type="Rhea" id="RHEA:52716"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:77396"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="EC" id="1.2.1.84"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the fatty acyl-CoA reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.84" evidence="10"/>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A295"/>
    <dbReference type="FunCoup" id="A0A5N4A295">
        <property type="interactions" value="72"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A295"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102965">
        <property type="term" value="F:alcohol-forming long-chain fatty acyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080019">
        <property type="term" value="F:alcohol-forming very long-chain fatty acyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035336">
        <property type="term" value="P:long-chain fatty-acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05236">
        <property type="entry name" value="FAR-N_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09071">
        <property type="entry name" value="FAR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000143">
        <property type="entry name" value="Fatty acyl-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026055">
        <property type="entry name" value="FAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033640">
        <property type="entry name" value="FAR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011:SF118">
        <property type="entry name" value="FATTY ACYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011">
        <property type="entry name" value="MALE STERILITY PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03015">
        <property type="entry name" value="Sterile"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0521">NADP</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="348"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="474"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="Thioester reductase (TE)" evidence="12">
        <location>
            <begin position="16"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acyl-CoA reductase C-terminal" evidence="11">
        <location>
            <begin position="358"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00052530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAB0791432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="497" mass="56465" checksum="5CB6D07E3A0CE940" modified="2020-02-26" version="1">MTPTVSEWFSDQHVLITGATGFMGKVLVEKLLRCCPKIATIYVLVRPKRGRNPQQRLEDFVNTPVFDRVRDTNVKLFQKLHCVSGDLIQSELGMSNDDIQLLQDRVTVVFHMAANVRFDQSLKTALVMNTGGTLMVLELIASFKRLRAFVHVSTSYCHCDETVLEERVYFAPHRPRKMLDLASWIDEDILKGLTPKFLKNSPNTYAYTKCLTEELVWEYRAKFPIAIVRPSIVIASWKEPMPGWIDNLNGPTGLLVGAGKGVIRSMHCDPSYEADLVPVDICTNSIILTAWKLGTTAPSGEPLVLNVTMPSENSITWGEALEMGRRHFYNNPFSVCLWYPDGGITSNYWVHAACVLLFHVIPAYLIDFLLILTRGKPFLVRTQKRIANGLGVLQYYTTRTWHFKNEGIGKIARSLTSHDSLVFYTSTVDLNWSNYLLSYVLGARKYCVHEEPSTIPYARKVLRRLYYLDAAKNIVFGAIFIWLTYVVFLRVLSAVAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A2A2</accession>
    <name>A0A5N4A2A2_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_03255</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A2A2"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024463580" evidence="2">
        <location>
            <begin position="19"/>
            <end position="1854"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="420"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="585"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="613"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="732"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="874"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="967"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1063"/>
            <end position="1524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1571"/>
            <end position="1665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1689"/>
            <end position="1784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="426"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="453"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="874"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="988"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1581"/>
            <end position="1592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1593"/>
            <end position="1606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1632"/>
            <end position="1652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1693"/>
            <end position="1708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1710"/>
            <end position="1719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1762"/>
            <end position="1775"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0791455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1854" mass="194045" checksum="BD59944FEDC4AF43" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A3J3</accession>
    <name>A0A5N4A3J3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ODAD1 central coiled coil region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_03658</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A3J3"/>
    <dbReference type="FunCoup" id="A0A5N4A3J3">
        <property type="interactions" value="8"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A3J3"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051876">
        <property type="entry name" value="ODA-DC/CCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049258">
        <property type="entry name" value="ODAD1_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21694">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21694:SF18">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21773">
        <property type="entry name" value="ODAD1_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ODAD1 central coiled coil region" evidence="3">
        <location>
            <begin position="145"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="42"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="265"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="377"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0791858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="489" mass="57829" checksum="7F79E5C86F38D074" modified="2020-02-26" version="1">MDRDKKPLTAQEKIEMDLMAEAELGKLQRQYRIMECDRKAFSEETNTKLAKQRKVIAALKKEQAELLTDLKAAASDSNKRKDRKMTAKVNRLLDEHENYTRLIAREKSRLQDVSREIRKLERRVDQVRGKDIPDRQFEDKVRGAQRAAQALENQLDYETKRFCAVLEDNRDLRERIEHLLKDRAHFNSVWETLVEDLNQGKKLMLDLIEQATLSYDQREEWCSKLHALRIRNRNDFMLHAEEMKELQRQLDHDSKLYEFLGIKGQKRIMRDLEEKEMKKVELQKEEVIKQQERYQKMLVEIRELVGEEDVSRLASQYFKQEEENFALFNYVNELNHEIEVILEETEKLRTNIGKKSVSNYRLIEFSEDQKEINDLKADQQQKTVQTLTEDLEAATMQTERARKEMEEAEADLESILKGIDGLFQLIECDYAPILQLLGEDAAINQDNVMLYLGVLEKKVGELTANMYLKEKSLFAKKRRAIQTKDEKHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A4J6</accession>
    <name>A0A5N4A4J6_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_14177</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A4J6"/>
    <dbReference type="InParanoid" id="A0A5N4A4J6"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0792218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="70" mass="7905" checksum="6C3839898A234695" modified="2020-02-26" version="1">MVTSRDRSIRPPDVRLSRRSESRSSLSVSYERLHLAEEFIYADSNGAVELILEGLIADPDEASLKINQED</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A509</accession>
    <name>A0A5N4A509_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 17">Exonuclease 1</fullName>
            <ecNumber evidence="17">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">PPYR_14383</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">1611_PpyrPB1</strain>
            <tissue evidence="21">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">5'-&gt;3' double-stranded DNA exonuclease which may also possess a cryptic 3'-&gt;5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="17">Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 17">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the XPG/RAD2 endonuclease family. EXO1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="17"/>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A509"/>
    <dbReference type="FunCoup" id="A0A5N4A509">
        <property type="interactions" value="820"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A509"/>
    <dbReference type="OrthoDB" id="26491at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035312">
        <property type="term" value="F:5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09908">
        <property type="entry name" value="H3TH_EXO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09857">
        <property type="entry name" value="PIN_EXO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000011">
        <property type="entry name" value="exonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000002">
        <property type="entry name" value="Exonuclease 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037315">
        <property type="entry name" value="EXO1_H3TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044752">
        <property type="entry name" value="PIN-like_EXO1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019974">
        <property type="entry name" value="XPG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF8">
        <property type="entry name" value="EXONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00841">
        <property type="entry name" value="XPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 17" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9 17" id="KW-0228">DNA excision</keyword>
    <keyword evidence="15 17" id="KW-0234">DNA repair</keyword>
    <keyword evidence="14 17" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="13 17" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="11 17" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="10 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 17" id="KW-0540">Nuclease</keyword>
    <keyword evidence="16 17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="20">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="19">
        <location>
            <begin position="138"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="408"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU910737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAB0792424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="628" mass="71571" checksum="C94D5947CB7491B2" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A5M7</accession>
    <name>A0A5N4A5M7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transcription initiation protein SPT3 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_14570</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the SPT3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A5M7"/>
    <dbReference type="FunCoup" id="A0A5N4A5M7">
        <property type="interactions" value="343"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A5M7"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07978">
        <property type="entry name" value="HFD_TAF13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000023">
        <property type="entry name" value="transcription initiation protein SPT3 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003195">
        <property type="entry name" value="TFIID_TAF13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID/SUPT3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380:SF16">
        <property type="entry name" value="TRANSCRIPTION INITIATION PROTEIN SPT3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02269">
        <property type="entry name" value="TFIID-18kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0010">Activator</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00061274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0792611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="295" mass="34070" checksum="C6EBD55A4382C752" modified="2020-02-26" version="1">MEPQKVTYCTEISLMMFGFGDSHKPNPETVRFVESIVLRQLRTIVHEATRYWDGKLLGGEELIFLMRKNKWKMRRFVKYLNLKHLKTQCETEMNAEFQTKTPQSRHPLLEFIERIDETGELTDLSELDEVIHRRQVRADCISQALDDSKYLEFQKARCVSFNSRGTSRSANLEKLRAWIDPKKQINTSGIALEVLAYYAYQTVAEIIDYALLVRMDARRSSDPLGNLAGLHYTAAMFVGEHRFSGSNPDYSRVYSGQPPITVAEIREVMRRFNVPQAGRLTFGGRLPETSFLFAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A5R1</accession>
    <name>A0A5N4A5R1_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PPYR_14606</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A5R1"/>
    <dbReference type="InParanoid" id="A0A5N4A5R1"/>
    <dbReference type="OrthoDB" id="6371647at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000028">
        <property type="entry name" value="Serine protease easter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022700">
        <property type="entry name" value="CLIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051333">
        <property type="entry name" value="CLIP_Serine_Protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038565">
        <property type="entry name" value="CLIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24260:SF145">
        <property type="entry name" value="FI17609P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12032">
        <property type="entry name" value="CLIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00680">
        <property type="entry name" value="CLIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51888">
        <property type="entry name" value="CLIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
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            <begin position="31"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="9">
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            <begin position="110"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51888"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAB0792647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="348" mass="39068" checksum="452A078B9AE946E0" modified="2020-02-26" version="1">MGIMPSSFLVLAAFFFAATYSDMIDIRITEDCTTPNGDKGKCKLLEDCPHAVSLFANPSKEIVNYMQGFLCKFSDPALPGAAICCTEPPPKRAVIPDKRYCGFQHSDDLMLDIRKTSIIEFPWLSAIMKKDQGGEDVVTCLGTLITNRYVLTSGFCAEKTGTWVRLGEFYVKNKTDCETWKSELNDCNQHEDFQIEEAVPHPFINTGISSLNDIGLLRLEKSVSYSDYIRPICLPSPTEKVEVQFFTSGWDDSQLKIKIPSTLASDRECLGEGSALSKYSKCVRYQNVEGGRESCHVINNGAPIMASAKYQWYLEGVSHMFYQKNGSCFAKFTPIVPYMDWIKNNLRS</sequence>
</entry>
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    <accession>A0A5N4A5S3</accession>
    <name>A0A5N4A5S3_PHOPY</name>
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        <recommendedName>
            <fullName evidence="9">Protein stum</fullName>
        </recommendedName>
    </protein>
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        <name evidence="7" type="ORF">PPYR_14577</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
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            <taxon>Elateroidea</taxon>
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        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:sensory perception of mechanical stimulus"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:taxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="SPEC3/Stum"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN STUM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21676:SF6">
        <property type="entry name" value="PROTEIN STUM"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="722"/>
            <end position="749"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="5">
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        </location>
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        <source>
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        <source>
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        </source>
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        <source>
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        </source>
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        </source>
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        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="833" mass="91494" checksum="303AD8818F534D2E" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A5T2</accession>
    <name>A0A5N4A5T2_PHOPY</name>
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        <recommendedName>
            <fullName evidence="6">LRRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="4" type="ORF">PPYR_14621</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="GH01279p"/>
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        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Leu-rich_rpt"/>
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        <property type="entry name" value="LRR_dom_sf"/>
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    </dbReference>
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        <property type="match status" value="3"/>
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        <property type="match status" value="8"/>
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        <location>
            <begin position="467"/>
            <end position="486"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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        <source>
            <dbReference type="EMBL" id="KAB0792662.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
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    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="519" mass="58291" checksum="16F55692AD74AF83" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A663</accession>
    <name>A0A5N4A663_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">B30.2/SPRY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PPYR_14783</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
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            <taxon>Coleoptera</taxon>
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    <reference evidence="6 7" key="1">
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                <person name="Bessho-Uehara M."/>
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                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
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                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
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                <person name="Weng J.K."/>
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            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPSB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A663"/>
    <dbReference type="FunCoup" id="A0A5N4A663">
        <property type="interactions" value="126"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A663"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12906">
        <property type="entry name" value="SPRY_SOCS1-2-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.750.20:FF:000001">
        <property type="entry name" value="Ankyrin repeat and SOCS box containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.920:FF:000007">
        <property type="entry name" value="SPRY domain-containing SOCS box protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.750.20">
        <property type="entry name" value="SOCS box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050672">
        <property type="entry name" value="FBXO45-Fsn/SPSB_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001496">
        <property type="entry name" value="SOCS_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12245:SF11">
        <property type="entry name" value="PROTEIN GUSTAVUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12245">
        <property type="entry name" value="SPRY DOMAIN CONTAINING SOCS BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07525">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00969">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50225">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="4">
        <location>
            <begin position="146"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="SOCS box" evidence="5">
        <location>
            <begin position="333"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0792824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="389" mass="43684" checksum="46376E41C271B33B" modified="2020-02-26" version="1">MITTPLFGVCWLPNNFSVLSVHNKLLGQLVWNNQCFLTFGHVQSAPYVGFWNSIAIFQPSHSFTMETRYRSGFRSSTVRNTSGAGSGRLCEVRRAYKAAVVPCKTGRRRARGMSMGQKVSGGVKSVSRDAAAPYKPVIPRELAQRPARLDMLLDMPPALRETQLKYSWNADDRSLNIFVKEDDKLTFHRHPVAQSTDCIRGKIGFTKGLHAWEVSWSTRQRGTHAVVGVATSEAPLHSVGYQSLVGSTDSSWGWDLGRNKLYHDSKNYAGVTYPALLKPDETFIVPDKFVVVLDMDEGTLSFMVDGQYLGVAFRGLKGRKLYPIVSAVWGHCEITMKYIGGLDPEPLPLTDLCRRIIRQRIGKANIEERVSSLNLPQPLQTYLLYRDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A6Q9</accession>
    <name>A0A5N4A6Q9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aromatic amino acid beta-eliminating lyase/threonine aldolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_12621</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the threonine aldolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A6Q9"/>
    <dbReference type="FunCoup" id="A0A5N4A6Q9">
        <property type="interactions" value="112"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A6Q9"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008732">
        <property type="term" value="F:L-allo-threonine aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006545">
        <property type="term" value="P:glycine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:L-threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000030">
        <property type="entry name" value="Low-specificity L-threonine aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001597">
        <property type="entry name" value="ArAA_b-elim_lyase/Thr_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023603">
        <property type="entry name" value="Low_specificity_L-TA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041359">
        <property type="entry name" value="GntG_guanitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48097:SF9">
        <property type="entry name" value="L-THREONINE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48097">
        <property type="entry name" value="L-THREONINE ALDOLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01212">
        <property type="entry name" value="Beta_elim_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017617">
        <property type="entry name" value="Thr_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aromatic amino acid beta-eliminating lyase/threonine aldolase" evidence="6">
        <location>
            <begin position="15"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5">
        <location>
            <position position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR017617-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0793001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="382" mass="41962" checksum="C84B83F5A8F37F8B" modified="2020-02-26" version="1">MPQNHVSGEGVRIVDIRTDTITKPTQAMRNVMAIAEVGDSVFGEDPTVDKLERRCADLLGKEDAVYLPSGTMCNLIAIMVHCNKRGVEFIAGDKSHSYLCELGGAAVLAGVQCSQIHNKPDGTFCLEELQRRIHPEVNLRSATTGLIIIENTHNLCGGKVLPLEWIDDLAKIASKFKVPLHMDGARIMNAVVQSKVPAKRIARDMDSVFFCFSKGLGCPMGSVLCGTASFVNEARRLRKMLGGDVRQVGIIAAACLLALDEMIDRLQIDHDHALQIAKAIDDMQSDIVRVDLSSVQTNMALITFDSKLVTAKEFLEKLAHVSPTDSVQVCVKGGFINDEEARFVLQWEVTDEDVSCAIEKVKMVIGQIHQDLKRRGKKRPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A6T3</accession>
    <name>A0A5N4A6T3_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_12588</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0792968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A6T3"/>
    <dbReference type="InParanoid" id="A0A5N4A6T3"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0792968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="156" mass="17711" checksum="112DB67BFC192064" modified="2020-02-26" version="1">MVVNVAVTITPQNRINKRESVEYSEDNLCNMLPKHRLAIMLCTTLVRSKQSTQLVRKTPSCRRGIDPSLSNKKNPMSSCSKDMRSNSIDKRSHRMCRHSEWKSKAYLQNHADRPNLKAPVAHNTHSGCPNGERTHFVAHRLRHPPDVAAVCTCSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A6U6</accession>
    <name>A0A5N4A6U6_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PPYR_12667</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A6U6"/>
    <dbReference type="InParanoid" id="A0A5N4A6U6"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070531">
        <property type="term" value="C:BRCA1-A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031436">
        <property type="term" value="C:BRCA1-BARD1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0085020">
        <property type="term" value="P:protein K6-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF8">
        <property type="entry name" value="BRCA1-ASSOCIATED RING DOMAIN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="44"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="79"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="113"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="146"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="179"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="212"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="269"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="417"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="459"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="361"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="272"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="286"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="420"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="459"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0793047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="650" mass="70612" checksum="AB5479195A6E24ED" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A8F2</accession>
    <name>A0A5N4A8F2_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_13215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A8F2"/>
    <dbReference type="InParanoid" id="A0A5N4A8F2"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23992">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.20">
        <property type="entry name" value="Pheromone/general odorant binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006170">
        <property type="entry name" value="PBP/GOBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036728">
        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01395">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024347993" evidence="1">
        <location>
            <begin position="23"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0793595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="147" mass="16968" checksum="4C50D5FE0913996E" modified="2020-02-26" version="1">MSAVLWRITLLCVLLQATHVLSEYFDNEHAQRCREENKVEISDLEGVFDENDIVVRSDSRLHALMLCMYQRQNLIKDGKYVRDAVIKHIAERPTPIDVAEKVFDKCRTEDEEVTGEIAINLRNCLIKEIGEYFASVKGSESNDTRNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A8N5</accession>
    <name>A0A5N4A8N5_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_13300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="6681239at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001164">
        <property type="entry name" value="GH01279p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050333">
        <property type="entry name" value="SLRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45712">
        <property type="entry name" value="AGAP008170-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45712:SF22">
        <property type="entry name" value="INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN COMPLEX ACID LABILE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0793680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="550" mass="62169" checksum="695B0D7345FF09C2" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2024-11-27" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AA68</accession>
    <name>A0A5N4AA68_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">E3 ubiquitin-protein ligase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_13837</name>
        <name evidence="2" type="ORF">PPYR_13846</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0794217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0794226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AA68"/>
    <dbReference type="InParanoid" id="A0A5N4AA68"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004162">
        <property type="entry name" value="SINA-like_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45877">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SIAH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45877:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SINA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0794217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0794226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="353" mass="40591" checksum="288334CAE9756598" modified="2020-02-26" version="1">MPSIPEGILDKLTCVQCHEWLSCGPIRLLPNGGSICGRCPRFEGPRDQYRHFAFEALACYFKFPCRNWGDGCQEWMPFKGVMNHEKNCSYGSTCSVLCCHPLAFIKSKRHLDAHSGNDVTMPLAIKLEIIPDGVLEYLRCTNCAGYLSYTPIYVCRDGTSICQRCTSQLPQPDGEFIRDFSFERFVDMMIFPCIYRYRGCTLLFKFGQEMKNHELDCPYGKPYKREPTAPKSDPQEDIQRKGVIKTLSGHIYATITPNAPLFAAPSTSNKEQQALFLDEFQKHRENLSSKWGRYNEDDYQNEYVNQVTHLNVIDELKIKQQYRNSSGNNGDMNAYYNHTEAQKADYSVYNQRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AAC0</accession>
    <name>A0A5N4AAC0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Dynein regulatory complex subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Coiled-coil domain-containing protein 65</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PPYR_13818</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">1611_PpyrPB1</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Plays a critical role in the assembly of N-DRC and also stabilizes the assembly of multiple inner dynein arms and radial spokes. Coassembles with DRC1 to form a central scaffold needed for assembly of the N-DRC and its attachment to the outer doublet microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Flagellum axoneme</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
            <location evidence="8">Cytoskeleton</location>
            <location evidence="8">Flagellum basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DRC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0794198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AAC0"/>
    <dbReference type="FunCoup" id="A0A5N4AAC0">
        <property type="interactions" value="46"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AAC0"/>
    <dbReference type="OrthoDB" id="7760980at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005858">
        <property type="term" value="C:axonemal dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070286">
        <property type="term" value="P:axonemal dynein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060285">
        <property type="term" value="P:cilium-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003352">
        <property type="term" value="P:regulation of cilium movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039505">
        <property type="entry name" value="DRC1/2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039750">
        <property type="entry name" value="DRC1/DRC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21625:SF0">
        <property type="entry name" value="DYNEIN REGULATORY COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21625">
        <property type="entry name" value="NYD-SP28 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14772">
        <property type="entry name" value="NYD-SP28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0969">Cilium</keyword>
    <keyword evidence="4 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0282">Flagellum</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynein regulatory complex protein 1/2 N-terminal" evidence="15">
        <location>
            <begin position="27"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="371"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="13"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="474"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="379"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="395"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF14772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAB0794198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="534" mass="62773" checksum="D2D6A7667ED671C5" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AAD0</accession>
    <name>A0A5N4AAD0_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_13859</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0794239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AAD0"/>
    <dbReference type="InParanoid" id="A0A5N4AAD0"/>
    <dbReference type="OrthoDB" id="6688683at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032222">
        <property type="term" value="P:regulation of synaptic transmission, cholinergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030431">
        <property type="term" value="P:sleep"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031424">
        <property type="entry name" value="QVR-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17064">
        <property type="entry name" value="QVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0794239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="130" mass="13620" checksum="7D6C36A18DDC3AC9" modified="2020-02-26" version="1">MLNSFAASALKCYSCTGFTCGYGLLSFTYPEVECEARTGISVLDAVASIVPTQCVKIVGKDEQGNGFVARNCTPYSGQVACNLIAGALEIGSGHKDLECYTCTDNLCNSATQFTGMAVVGLIIACFAFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ABJ8</accession>
    <name>A0A5N4ABJ8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Nephrin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PPYR_11536</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0794697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ABJ8"/>
    <dbReference type="FunCoup" id="A0A5N4ABJ8">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4ABJ8"/>
    <dbReference type="OrthoDB" id="10006996at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23278:SF31">
        <property type="entry name" value="SIDESTEP II, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23278">
        <property type="entry name" value="SIDESTEP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="460"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="58"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="154"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="252"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="7">
        <location>
            <begin position="351"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="503"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0794697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="644" mass="71125" checksum="A676473B46F00266" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ADH7</accession>
    <name>A0A5N4ADH7_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_12214</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRP12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0795375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A5N4ADH7">
        <property type="interactions" value="1493"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4ADH7"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012978">
        <property type="entry name" value="HEAT_RRP12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057860">
        <property type="entry name" value="HEAT_RRP12_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052087">
        <property type="entry name" value="RRP12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48287">
        <property type="entry name" value="ARM REPEAT SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48287:SF1">
        <property type="entry name" value="ARM REPEAT SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25772">
        <property type="entry name" value="HEAT_RRP12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08161">
        <property type="entry name" value="RRP12_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRP12 N-terminal HEAT" evidence="6">
        <location>
            <begin position="111"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="RRP12 HEAT" evidence="5">
        <location>
            <begin position="426"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1041"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1118"/>
            <end position="1259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1276"/>
            <end position="1297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1073"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1118"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1149"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1232"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1277"/>
            <end position="1286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1287"/>
            <end position="1297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0795375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1297" mass="144570" checksum="B6EB296431A0CDB9" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ADK2</accession>
    <name>A0A5N4ADK2_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PPYR_12235</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acyl-CoA oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0795396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ADK2"/>
    <dbReference type="InParanoid" id="A0A5N4ADK2"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005504">
        <property type="term" value="F:fatty acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016402">
        <property type="term" value="F:pristanoyl-CoA oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033540">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA oxidase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000007">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055060">
        <property type="entry name" value="ACOX_C_alpha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012258">
        <property type="entry name" value="Acyl-CoA_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002655">
        <property type="entry name" value="Acyl-CoA_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909">
        <property type="entry name" value="ELECTRON TRANSPORT OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909:SF390">
        <property type="entry name" value="PEROXISOMAL ACYL-COENZYME A OXIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01756">
        <property type="entry name" value="ACOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22924">
        <property type="entry name" value="ACOX_C_alpha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA oxidase C-alpha1" evidence="10">
        <location>
            <begin position="59"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase C-terminal" evidence="9">
        <location>
            <begin position="259"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF22924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0795396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="443" mass="50556" checksum="E35D81F1B1153659" modified="2020-02-26" version="1">MWSTGKVEMTISFRLIMFNKYRIPKENLLNRLADVNDDGVYISTVVNPKLQFANSLSMLSTARVNIAGFCTEYMRYGITIAIRNASVVKQRLPENGRDLPILENPAHQIRLTPCLALAYVGHVVFGYLAAIQSQFTSITDEDVLINLGNEYHALSSAAKPVSSWLIRDFMKDCKEICGSHVYLTKMEEIYGEVEPSSNYEGDNYVLTQQCANFLLKLWPIVMRGGRIDFPLSSVNFLSNAKEILKCKFTANNTADFVQPENILTCFQWLTCYLLKETFEKQQLLGKSETNPFWIKNNSQVYYCRALATAYILTFYIDRFRQIISNTADIATKTVLIKLLSLYGVWNLHNYVHYFYQGGFAIGAEFGHMIENVILKLCMDLKDDIVALVDAIAPPDFLLNSVFGHSDGHIYERLESTITHTPETFSKAKWRGDVSEWKYQLSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AEK4</accession>
    <name>A0A5N4AEK4_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_09790</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0795729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AEK4"/>
    <dbReference type="InParanoid" id="A0A5N4AEK4"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097363">
        <property type="term" value="F:protein O-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000252">
        <property type="entry name" value="O-linked N-acetylglucosamine (GlcNAc) transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037919">
        <property type="entry name" value="OGT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44366">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--PEPTIDE N-ACETYLGLUCOSAMINYLTRANSFERASE 110 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44366:SF1">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--PEPTIDE N-ACETYLGLUCOSAMINYLTRANSFERASE 110 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13414">
        <property type="entry name" value="TPR_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="109"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="143"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0795729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="247" mass="27348" checksum="B7E17A5764CFAF21" modified="2020-02-26" version="1">MQAQQVSGSQQSQASSGTTAAAPSATGGVLLKMNDLQPISSVGLLELAHREYQAGDYENGERHCMQLWRQDQTNTGVLLLLSSIHFQCRRLDKSAQFSTLAIKQNPLLAEAYSNLGNVYKERGQLQEALDNYRHAVRLKPDFIDGYINLAAALVAAGDMEQAVQAYITALQYNPELYCVRSDLGNLLKALGRLDEAKVRLFQLLSLFLSPSSFRATILSCANCEFLSLCINYYFVAKRILLRTTSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AFM4</accession>
    <name>A0A5N4AFM4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cubilin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PPYR_10184</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AFM4"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000279">
        <property type="entry name" value="Neurogenic locus notch 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24255">
        <property type="entry name" value="COMPLEMENT COMPONENT 1, S SUBCOMPONENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24255:SF31">
        <property type="entry name" value="CUBILIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-type lectin" evidence="9">
        <location>
            <begin position="152"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="7">
        <location>
            <begin position="311"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="9">
        <location>
            <begin position="449"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="7">
        <location>
            <begin position="589"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="7">
        <location>
            <begin position="711"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="971"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="1012"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="1044"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1203"/>
            <end position="1235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1339"/>
            <end position="1368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1425"/>
            <end position="1457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1641"/>
            <end position="1666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1743"/>
            <end position="1853"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1983"/>
            <end position="2123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="2154"/>
            <end position="2188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1211"/>
            <end position="1223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1358"/>
            <end position="1368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1425"/>
            <end position="1440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1750"/>
            <end position="1768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1814"/>
            <end position="1832"/>
        </location>
    </feature>
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            <begin position="1834"/>
            <end position="1845"/>
        </location>
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    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1994"/>
            <end position="2010"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="2055"/>
            <end position="2066"/>
        </location>
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        <location>
            <begin position="2071"/>
            <end position="2090"/>
        </location>
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        <location>
            <begin position="2101"/>
            <end position="2110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="2111"/>
            <end position="2123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="2169"/>
            <end position="2178"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="711"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="997"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="1032"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="1070"/>
            <end position="1079"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0796123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2237" mass="247844" checksum="BADB0F69C212BE4F" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AFQ9</accession>
    <name>A0A5N4AFQ9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Sodium/solute symporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PPYR_10226</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="InParanoid" id="A0A5N4AFQ9"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051163">
        <property type="entry name" value="Sodium:Solute_Symporter_SSF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00813">
        <property type="entry name" value="sss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985">
        <property type="entry name" value="SODIUM-COUPLED MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985:SF21">
        <property type="entry name" value="SODIUM-DEPENDENT MULTIVITAMIN TRANSPORTER-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="10" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
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            <end position="65"/>
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    <feature type="transmembrane region" description="Helical" evidence="12">
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            <end position="100"/>
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    <feature type="transmembrane region" description="Helical" evidence="12">
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            <end position="144"/>
        </location>
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        <location>
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            <end position="178"/>
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    <feature type="transmembrane region" description="Helical" evidence="12">
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            <end position="212"/>
        </location>
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            <end position="395"/>
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    <feature type="transmembrane region" description="Helical" evidence="12">
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            <end position="422"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
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            <end position="455"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="502"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAB0796165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="572" mass="62211" checksum="CEED1AFD4B6C5C76" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-06-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AFY2</accession>
    <name>A0A5N4AFY2_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_10313</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AFY2"/>
    <dbReference type="InParanoid" id="A0A5N4AFY2"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0796252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="103" mass="12625" checksum="210D77241A93DC77" modified="2020-02-26" version="1">MAEVNKKKRTDKQNLHRSRQLNPCDILYWKSRGFSERPHDWQARVYGVNKYHHHEEYHFQGNGWKMTRWDNRSCVPALSRAITQHYRHGGVFVYNVYIYNFRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AG06</accession>
    <name>A0A5N4AG06_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_10318</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AG06"/>
    <dbReference type="InParanoid" id="A0A5N4AG06"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02961">
        <property type="entry name" value="PDI_a_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051063">
        <property type="entry name" value="PDI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45672:SF11">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE C17H9.14C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45672">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE C17H9.14C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024400872" description="Thioredoxin domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="15"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0796257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="131" mass="14631" checksum="4FAADD61048BB99E" modified="2020-02-26" version="1">MSSLPLCLIGIVLVLPLGSNGNVIKLTESNFNEMTSQNKIMVKFCMCALDTTWCSYCKKMAEPYIKLAKELKDTGSDIKVAEVDCEKYSRVCDKAGIKGLPTLQYYRNGSPTEYKGQRTTKPMLQWLTSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AG28</accession>
    <name>A0A5N4AG28_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PPYR_10363</name>
        <name evidence="7" type="ORF">PPYR_15535</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01001845">
        <property type="protein sequence ID" value="KAB0790141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AG28"/>
    <dbReference type="InParanoid" id="A0A5N4AG28"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001827">
        <property type="entry name" value="Homeobox_Antennapedia_CS"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00032">
        <property type="entry name" value="ANTENNAPEDIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="17"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="17"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="85"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="122"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="145"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="156"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="188"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0790141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0796302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="238" mass="24494" checksum="3A36E28D67F1C87F" modified="2020-02-26" version="1">MSSYQFVNSLAQCYGQQPRAAAASDQAAHQVSSPGSDYYNPNAASASSYPPACYSPPQVGPQYHQHPYATPAPGHGLQPAMGDYTQLQPQRLTGTSTHMHHSSPGAQSPGILNAAASCKYADSTSSTGVASPQDLSTTGAPARSTPPMSSSQTSSNATLTAKNSALTSPLSVSTSPQGKQPTSSTTASQNLSSPASSTSSTSSTEKTGGSNNNSKNSTSQNPPQIYPWMKRVHLGQSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AHE3</accession>
    <name>A0A5N4AHE3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_10784</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AHE3"/>
    <dbReference type="InParanoid" id="A0A5N4AHE3"/>
    <dbReference type="OrthoDB" id="6247875at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22031">
        <property type="entry name" value="HMG-box_SoxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000004">
        <property type="entry name" value="Transcription factor SOX-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022151">
        <property type="entry name" value="Sox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050917">
        <property type="entry name" value="SOX_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45803">
        <property type="entry name" value="SOX100B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45803:SF5">
        <property type="entry name" value="SOX100B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12444">
        <property type="entry name" value="Sox_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HMG box" evidence="8">
        <location>
            <begin position="82"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="6">
        <location>
            <begin position="82"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="183"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="189"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0796723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="395" mass="44411" checksum="275D9F3A8924BC6C" modified="2020-02-26" version="1">MLSSGNLVRSSPVPINSNAAASIAAASVASIINETSTSPKVENASLDKSEINEAVSKVLRGYDWSLVPIATKASSDKRKLHVKRPMNAFMVWAQAARRKLADQYPQLHNAELSKTLGKLWRLLNDADKKPFVEEAERLRVIHKRDHPDYKYQPRRRKQNKGSTESLNQLTHVQNVSFGRCLKQEDSPCSPRSQNSTSPSSCSSPQSPSLSAGQPLRHCMEQAGSSIDFNRLPDLDNSYMPEDCLDSHDLDQYLPQDNGHAFPANVYHETYKRHIEEDESNNNTHKIKKMCADPLGQPHEVFEEHTTPLPFIRYHELQPTNPLTKTERYVPPPTTSVFGYNHLSTTSGYYTNSGHHQYLPPYQYLPQRSPVFGNPSMAAYGVNSATTSDTWTPYSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AHR2</accession>
    <name>A0A5N4AHR2_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MADF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_10877</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AHR2"/>
    <dbReference type="InParanoid" id="A0A5N4AHR2"/>
    <dbReference type="OrthoDB" id="6768983at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21505:SF8">
        <property type="entry name" value="DPT-YFP REPRESSOR BY OVEREXPRESSION, ISOFORM D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21505">
        <property type="entry name" value="MADF DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00595">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51029">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MADF" evidence="2">
        <location>
            <begin position="3"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="282"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0796816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="335" mass="37697" checksum="29E91F73A70571EF" modified="2020-02-26" version="1">MELFLESYQRYECLWNNKCSDYSKSNVREKAYLSMLADLNLPGLTVPDIKAKIKTIRTRYGAELCKIKNSERSGASADDVYEPRLFWFKLADVFLRSICTPKESSSNLKELESTRKGISGKATDDSQHLEEREQQTGQTAHIQDTEQQTEQTAHIQDTEATSPNTIATSSAVITNTPKNTKGRKRSLNTTISGVQDAIKQLKTLSEENKEDLNEFDVFCESLAIQLKKMPLNRALICQEHLQKVMTQERPFQLTSNPQSHSSMSPADYQQSIPTSGRYSAMSSGQSSTHSRQSQNHYYQSTEKDDDYESTQYTSDVLSDALSSAGLIVGDELMPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AI88</accession>
    <name>A0A5N4AI88_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_08069</name>
        <name evidence="2" type="ORF">PPYR_10014</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0795953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AI88"/>
    <dbReference type="FunCoup" id="A0A5N4AI88">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AI88"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23992">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.20">
        <property type="entry name" value="Pheromone/general odorant binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006170">
        <property type="entry name" value="PBP/GOBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036728">
        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01395">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00708">
        <property type="entry name" value="PhBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036147791" evidence="1">
        <location>
            <begin position="17"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0795953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0797075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="138" mass="15445" checksum="BB1882BD7B4DDA63" modified="2020-02-26" version="1">MKTCILISLLFYTASAFKYNVHLEVSKAWDIMASFPREKCILQTGVDRNAANVALLNMDLPEDYPFKCFSKCIFVELGFYNPATDTFNSDRILKGLVGIPSGLVEECSEKHKGVRDQCERVFSVITCGIAKIQSLPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AIQ9</accession>
    <name>A0A5N4AIQ9_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_08177</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AIQ9"/>
    <dbReference type="InParanoid" id="A0A5N4AIQ9"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0797183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="208" mass="23808" checksum="2B416CC11892B904" modified="2020-02-26" version="1">MFGTNGIFPWGVSHSCDRSPFSSSTICMQCPSPMHPCACPSIRKPPLTLEQHIVCRQLKNDWLELKQIQKTIERRPPHDDCALTINWPECSTNLFVENRVNLPLAHHLRMSFKSDVEDTKGPMLFTRKRLALKKTPDLQWQPKWFSGNAMENEETLEVGVTADLAGNGTSRRERRKKDKKKSAYLLAYEFSDSSVDDSCEDYGAINKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AKA7</accession>
    <name>A0A5N4AKA7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carboxylesterase type B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PPYR_08785</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AKA7"/>
    <dbReference type="InParanoid" id="A0A5N4AKA7"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142:SF1">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="5">
        <location>
            <begin position="202"/>
            <end position="680"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0797792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="694" mass="78341" checksum="396672663A9F6ECE" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AKC3</accession>
    <name>A0A5N4AKC3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ras-associating domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_08783</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AKC3"/>
    <dbReference type="FunCoup" id="A0A5N4AKC3">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AKC3"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048699">
        <property type="term" value="P:generation of neurons"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01259">
        <property type="entry name" value="PH_APBB1IP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16138">
        <property type="entry name" value="RA_MRL_MIG10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039664">
        <property type="entry name" value="GRB/APBB1IP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039665">
        <property type="entry name" value="PH_APBB1IP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11243">
        <property type="entry name" value="GROWTH FACTOR RECEPTOR-BOUND PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11243:SF23">
        <property type="entry name" value="LD06925P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21989">
        <property type="entry name" value="RA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00314">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-associating" evidence="3">
        <location>
            <begin position="211"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="341"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="521"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="593"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="998"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1106"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="159"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="531"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="604"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="628"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="670"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="690"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="755"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="802"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="839"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="866"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="886"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="901"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="932"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="967"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1132"/>
            <end position="1141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0797790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1141" mass="126557" checksum="B759B583FE0C7883" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AKW4</accession>
    <name>A0A5N4AKW4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 13">Protein-S-isoprenylcysteine O-methyltransferase</fullName>
            <ecNumber evidence="4 13">2.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PPYR_08988</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + S-adenosyl-L-methionine = [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:21672"/>
            <dbReference type="Rhea" id="RHEA-COMP:12125"/>
            <dbReference type="Rhea" id="RHEA-COMP:12126"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90510"/>
            <dbReference type="ChEBI" id="CHEBI:90511"/>
            <dbReference type="EC" id="2.1.1.100"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Endoplasmic reticulum membrane</location>
            <topology evidence="13">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.100" evidence="4 13"/>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AKW4"/>
    <dbReference type="FunCoup" id="A0A5N4AKW4">
        <property type="interactions" value="683"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AKW4"/>
    <dbReference type="OrthoDB" id="422086at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004671">
        <property type="term" value="F:protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007269">
        <property type="entry name" value="ICMT_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025770">
        <property type="entry name" value="PPMT_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12714">
        <property type="entry name" value="PROTEIN-S ISOPRENYLCYSTEINE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12714:SF9">
        <property type="entry name" value="PROTEIN-S-ISOPRENYLCYSTEINE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04140">
        <property type="entry name" value="ICMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51564">
        <property type="entry name" value="SAM_ICMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="155"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="214"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAB0797995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="280" mass="32333" checksum="63BDF378FABFA1E9" modified="2020-02-26" version="1">MLCYIGQVSLYCFLGAAAPFLVSLMCNYHRFQFYGSFYLLPIIYFLLINAIVGLVYKKNTYKIAVRSVNLGFLLALGVYIRLVAPDHIQIFGLYMCTMSIFHYSEFLCMANIQPKLVSADSFVINHSVQYTIAALTSWVEFFVEAYFFPDLKTKFWLSHIGLVVCIIGELLRKAAMLTASSNFNHLVQCEKVEGHILVTHGVYSIFRHPSYVGWFYWSIGTQVILLNPLCIIAYTIASWTFFRERILIEEIMLLNFFGQQYCDYQEKVRTGLPFIDGYKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ALF8</accession>
    <name>A0A5N4ALF8_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_09163</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ALF8"/>
    <dbReference type="InParanoid" id="A0A5N4ALF8"/>
    <dbReference type="OrthoDB" id="6337960at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038832">
        <property type="entry name" value="CDCA3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34756">
        <property type="entry name" value="CELL DIVISION CYCLE-ASSOCIATED PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34756:SF1">
        <property type="entry name" value="CELL DIVISION CYCLE-ASSOCIATED PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0798170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="344" mass="38385" checksum="EDDDE87E95E1BCDD" modified="2020-02-26" version="1">MGSNLSRVQNGFKEEGDEKLPSAPIQTPQTRRLEFDPRSPSSHISRTPIEVLRTPLPKEASTCHSISVLDCNVSNEIDIDPRSPTADFHRTPLMIKGETKLPYGVHNKFLDKARRPPVTLTPLKQSAQVISTISNDVLEDTPPKLLETNTKLVKHIENKRHSFIGLLETNIDYVETDIDNVIIREKELNSDVDPLPVEVESGTAITESNQSENSYLPDIPDEETCSNISDASEAIPDITKCITEIDRKLTNLIYEDKEVNISPKVSKPIESGHRTPLSDRNANNQTKRTIPVLKVSDKPTKLQKGSKIPVLKGKDLKGAFGQCENTPPRLKNRSHWGKEDSLVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AMC5</accession>
    <name>A0A5N4AMC5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatidylinositol N-acetylglucosaminyltransferase subunit P</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PPYR_09483</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PIGP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AMC5"/>
    <dbReference type="FunCoup" id="A0A5N4AMC5">
        <property type="interactions" value="79"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AMC5"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017176">
        <property type="term" value="F:phosphatidylinositol N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052263">
        <property type="entry name" value="GPI_Anchor_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013717">
        <property type="entry name" value="PIG-P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016542">
        <property type="entry name" value="PIG-P_GPI19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46346">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46346:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08510">
        <property type="entry name" value="PIG-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF008765">
        <property type="entry name" value="PIG-P_GPI19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="6 7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="PIG-P" evidence="9">
        <location>
            <begin position="15"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR008765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0798490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="167" mass="19500" checksum="F8FC1B9113385D9C" modified="2020-02-26" version="1">MANKMPEHTPAPTPHRAVYGFALYLSFKVFFVLYVIWAVVPESWFKYLNITCLPQRYWAIAVPIFIITSLLIFGFIIYPSINLCMTPDFNDINTITDETTLQRKISKQLYTITKNSSRDCNCTDSTKCERRQYLKEFKNFNDKCIPSAEDLDISEVSKLLYSKNKHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-06-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AMG7</accession>
    <name>A0A5N4AMG7_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_09494</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AMG7"/>
    <dbReference type="InParanoid" id="A0A5N4AMG7"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0798501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="115" mass="13516" checksum="89FD9ABF752342C0" modified="2020-02-26" version="1">MTQKYADRLQDEARRLFYNTTITLNNTGIKILQIRLNVLSDMCCCARILKMSRDQSVYFNYETSIRIIDCLRLVDSVINRVYDRNSSYVNSQDLHIVVRSDEHKSNKYAIVRSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AMS1</accession>
    <name>A0A5N4AMS1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PPYR_00594</name>
        <name evidence="9" type="ORF">PPYR_09501</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AMS1"/>
    <dbReference type="FunCoup" id="A0A5N4AMS1">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AMS1"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF269">
        <property type="entry name" value="NUCLEASE HARBI1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="8">
        <location>
            <begin position="136"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0798508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0803624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="366" mass="41685" checksum="D023879466CCDDEF" modified="2020-02-26" version="1">MGMGILHMLNDELLQEDSAAYKNFLRLTNHQFEKLLRLVEPHISRQDTVMRQCVSARSRLELTLRFLATGESYRSLMYSSRIHESTISLFIPEVCEVIFNVLKDEFLMTPSTPESWQSIADQFMELWQFPQCVGALDGRHITFRSPKSAGSFYHNYKGDHSLVLLAMADACCKFTYINIGVNGRISDGGVFRDCTLSKAIQNNSLNFPQSRPLPGSSNNVPYVIVADDAFPLSTRILKPYPQRGLSHDKKIFNYRLSRARRIIEHAFGILANRFRVLLNPICLSPNKVEKITLACVALHNYLCTNSGQFYTDFDEASIITLDTWKPQGTNRTSRSALSVRDEYKNYFCSPTGSVEWQDAAVLRHNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-06-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ANE0</accession>
    <name>A0A5N4ANE0_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_06727</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0798847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ANE0"/>
    <dbReference type="InParanoid" id="A0A5N4ANE0"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0798847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="105" mass="12417" checksum="0AC8CD1487C00133" modified="2020-02-26" version="1" fragment="single">QFSYSLQGLTTTTPVHFNSLKYIENYYLILRQVTTEKKKRFTQLLKLDLHLELTPQLSAYPTNPLVPFKALCANRSCIILRYSTYSAISRKFVRLRCRYKTYAQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4APM4</accession>
    <name>A0A5N4APM4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase</fullName>
            <ecNumber evidence="6">3.1.4.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PPYR_07157</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6 9">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="8">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="6"/>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4APM4"/>
    <dbReference type="FunCoup" id="A0A5N4APM4">
        <property type="interactions" value="253"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4APM4"/>
    <dbReference type="OrthoDB" id="269822at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008344">
        <property type="term" value="P:adult locomotory behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043153">
        <property type="term" value="P:entrainment of circadian clock by photoperiod"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042592">
        <property type="term" value="P:homeostatic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046488">
        <property type="term" value="P:phosphatidylinositol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051209">
        <property type="term" value="P:release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00275">
        <property type="entry name" value="C2_PLC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13361">
        <property type="entry name" value="PH_PLC_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08591">
        <property type="entry name" value="PI-PLCc_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000024">
        <property type="entry name" value="1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1230.10:FF:000005">
        <property type="entry name" value="1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.240:FF:000001">
        <property type="entry name" value="1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000008">
        <property type="entry name" value="1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.190:FF:000005">
        <property type="entry name" value="1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1230.10">
        <property type="entry name" value="Phospholipase C beta, distal C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001192">
        <property type="entry name" value="PI-PLC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016280">
        <property type="entry name" value="PLC-beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042531">
        <property type="entry name" value="PLC-beta_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037862">
        <property type="entry name" value="PLC-beta_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053945">
        <property type="entry name" value="PLCB1-4-like_EFh"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF36">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17787">
        <property type="entry name" value="PH_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00387">
        <property type="entry name" value="PI-PLC-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22631">
        <property type="entry name" value="PLCB1-4-like_EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000956">
        <property type="entry name" value="PLC-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00390">
        <property type="entry name" value="PHPHLIPASEC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00149">
        <property type="entry name" value="PLCYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69989">
        <property type="entry name" value="C-terminal domain of PLC-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50008">
        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="2 6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6 9" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4 6 9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="PI-PLC Y-box" evidence="12">
        <location>
            <begin position="584"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="11">
        <location>
            <begin position="701"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="540"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1050"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="380"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="427"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="381"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="410"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="412"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="461"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000956-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000956-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAB0799277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1128" mass="130437" checksum="BB984A39CA0A640D" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4APT7</accession>
    <name>A0A5N4APT7_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_07186</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4APT7"/>
    <dbReference type="InParanoid" id="A0A5N4APT7"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061750">
        <property type="term" value="F:acid sphingomyelin phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006685">
        <property type="term" value="P:sphingomyelin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340">
        <property type="entry name" value="SPHINGOMYELIN PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340:SF29">
        <property type="entry name" value="SPHINGOMYELIN PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0799306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="115" mass="13378" checksum="1DBC0FA2BC8AE8FD" modified="2020-02-26" version="1">MEISTRWIFSLAAELWRDWLPPEATKTILRGGYYTALVRPGFRVIALNSNVCYSYNFWLLYEGSDPYGQLQWLIDTLLDAETNNEKVHILSHVPSGDSSCVKNWGREYVNIVNRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AQK5</accession>
    <name>A0A5N4AQK5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_07490</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AQK5"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053010">
        <property type="entry name" value="SET_SmydA-8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46455:SF2">
        <property type="entry name" value="AT24727P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46455">
        <property type="entry name" value="SET AND MYND DOMAIN CONTAINING, ARTHROPOD-SPECIFIC, MEMBER 4, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="6">
        <location>
            <begin position="16"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="5">
        <location>
            <begin position="43"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0799610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="624" mass="70606" checksum="676A32A978230A56" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ARJ8</accession>
    <name>A0A5N4ARJ8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Kinesin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PPYR_07855</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ARJ8"/>
    <dbReference type="FunCoup" id="A0A5N4ARJ8">
        <property type="interactions" value="51"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4ARJ8"/>
    <dbReference type="OrthoDB" id="540783at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005875">
        <property type="term" value="C:microtubule associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051231">
        <property type="term" value="P:spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969:SF15">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="9">
        <location>
            <begin position="4"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="489"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="595"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="756"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="80"/>
            <end position="87"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0799975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="909" mass="103454" checksum="004F97C5515FF52B" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AU94</accession>
    <name>A0A5N4AU94_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_05296</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000003">
        <property type="protein sequence ID" value="KAB0800942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AU94"/>
    <dbReference type="InParanoid" id="A0A5N4AU94"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0800942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="165" mass="18008" checksum="F4862A458DC82BA6" modified="2020-02-26" version="1">MRSKQIPAVVPLYVDNYEDLLDLEITATPMQGPTTSRAHMESKPCHHAIPPNPTMGQHFSVREHEKEKISSQTGPTEPSTGNAVVTAEESEPYSKEELKELMELFGLLMDDDDPSGQQSTETGPKAQDLEQLLTGEDAHTASGTGESSSDEKEALTCDDPPIRES</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AV33</accession>
    <name>A0A5N4AV33_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cuticle protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_05579</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000003">
        <property type="protein sequence ID" value="KAB0801225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AV33"/>
    <dbReference type="FunCoup" id="A0A5N4AV33">
        <property type="interactions" value="24"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AV33"/>
    <dbReference type="OrthoDB" id="6371055at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062129">
        <property type="term" value="C:chitin-based extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008010">
        <property type="term" value="F:structural constituent of chitin-based larval cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050468">
        <property type="entry name" value="Cuticle_Struct_Prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380">
        <property type="entry name" value="CUTICLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380:SF205">
        <property type="entry name" value="CUTICULAR PROTEIN 97EB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00947">
        <property type="entry name" value="CUTICLE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0193">Cuticle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024285147" description="Cuticle protein 6" evidence="3">
        <location>
            <begin position="19"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="83"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="118"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="147"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0801225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="254" mass="29504" checksum="6E79E5907808A747" modified="2020-02-26" version="1">MNCYILLISGLCFVVAKAQQYTTPVPILKQINKHNEDGSYSYGYEGADGAFKIETKYPNGEVHGKYGYVDDTGKLREIEYGASRRGFEPQGNDINVPPPTIHNNQPIRPLGPNEEDDGQYREDPSIYYKDETYNQPQQKNNYAAPKYTQTYQQPQTYQRQQTYQQPQTYQQPQTYQQPQIYQQPQTYHQPSRQATKFSFDDFISNHQPQQQQPQPAATYYNPRPAYNQHYQGGFGPATNVDLNYGSYSVNYRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AVG9</accession>
    <name>A0A5N4AVG9_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_05683</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000003">
        <property type="protein sequence ID" value="KAB0801329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AVG9"/>
    <dbReference type="InParanoid" id="A0A5N4AVG9"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34239">
        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34239:SF2">
        <property type="entry name" value="TRANSPOSABLE ELEMENT P TRANSPOSASE_THAP9 CONSERVED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0801329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="251" mass="27412" checksum="2184582F402E0239" modified="2020-02-26" version="1">MAPAATVTSSEGAPDPPDFDDRESPVLQINNEDDLPEAFLHVLGEDPRQNTPAPFDLHEALNSRWSHVIANGLVSSERDSLFKSYQLPSNCVALTPPILNPEISSILSGPNLKRDNAYLQMQTQLSHGSSALASAVHLILENKEIISQDLTARLLAGLSDASRIHLDLLHQMSQLRLTLIYPSLSKSVKVIVEKSTPLQFLFGKELGEQIKAAKLVAKAGKDLKAPITHLYCFVQTDFSKVCQGGKGGRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AX09</accession>
    <name>A0A5N4AX09_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PPYR_03999</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0801813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AX09"/>
    <dbReference type="InParanoid" id="A0A5N4AX09"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000358">
        <property type="entry name" value="zinc finger protein 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF49">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="73"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="101"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="129"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="50"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0801813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="162" mass="18416" checksum="01A920A895A19951" modified="2020-02-26" version="1">MKMTTKYNQDSEKSEKVCTAAHPYTCDCSTCITNLGNLPILMKVIEEQENIDQTTKPSTSSEKSNPVQPSSSMSCSSCGKNFVHRGDLNKHLRKHTKEQPYVCMVCKRKFAHSSNLNRHLQVHDGTRPFSCKTCMKTFGRKDKLEAHKKTKRCKNLSDKSIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AY73</accession>
    <name>A0A5N4AY73_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PPYR_04384</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AY73"/>
    <dbReference type="InParanoid" id="A0A5N4AY73"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="327"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0802198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="347" mass="38805" checksum="3272175EE65009B4" modified="2020-02-26" version="1">MTFLDSVSRAGSFTNAYIIVFEFVAPEKRTVVGVILNIACAISGIIVGALAWTLQTWRILDQILYGSSLMMVTYYWLLPESVRWLLTRKMYTKVEKILRSISKTNGTNLSENNLKELWRPAEPIPEITPHYMKELLNSPILTRRFINCALCWSIGLFSYYGLTINSVALSSNAYFDFILTMFVEIPGCVLVYFLLDTIGRPYSLAMGFFTCAVACSIFIFVPKHLYWLQLLTYLLGKFGTSVVISVVYIITSECFPTHLRSSLYSSCSMVGRVGPMIAPQIPLLKLYWQQLPLVLFGSTALVGSILSLQLPETKLIMLPDTVEEAESIGQGSIGQGSIGQRSDLSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AY93</accession>
    <name>A0A5N4AY93_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PPYR_04518</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">1611_PpyrPB1</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AY93"/>
    <dbReference type="InParanoid" id="A0A5N4AY93"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11056">
        <property type="entry name" value="CYP6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050476">
        <property type="entry name" value="Insect_CytP450_Detox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292:SF54">
        <property type="entry name" value="CYP9F3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0492">Microsome</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="435"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAB0802332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="491" mass="56966" checksum="C62C640F58755F6D" modified="2020-02-26" version="1">MFVTISILLLIFTIFYTWYVKKKYSYWEERGVPNPKPSLILGNIGKMITWQRTLTDFFKDVYREYEGYSYVGIYNCLTPAVVLRDPDLISDLLIRNFDSFTDTMIEIADPIASIHPGFVERDRWKTLRREMVGNLTKTKIKGMLVHIEKVCEEMLEYLKRKNYCVKATDLSFKFTGDNVMACAYGLDGKSFITGTSLMEQIRDEMSMSTKIGSLFHTSGLFFPKLCKLFQISYLGKQVPDKFKELIAMVVTYREDSTYAYNDFANFLKESKQKNDDNYFGYAMSFFLDGFETSGYALIYTLLEVTRNPIVQETARKEVEVTLKTHNTVHSYEALKSMVYLDSIIHETVRKHTVIKFINRKCTKDFVLPAPRAGHGKPVTITKGTHIFVPIEAIHRDEKYFPNSSKFDPNRFFDEHIMESRPKNAYLGFGDGPRVCLGKKFAVVQMKMILVTLLLNFTLKIHEKTVFPLGKEFYHLSKSPKGDIWIEFLPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AZL9</accession>
    <name>A0A5N4AZL9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="11">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PPYR_04952</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>acetylcholine + H2O = choline + acetate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17561"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15355"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="EC" id="3.1.1.7"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Synapse</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="11"/>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AZL9"/>
    <dbReference type="InParanoid" id="A0A5N4AZL9"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003990">
        <property type="term" value="F:acetylcholinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006581">
        <property type="term" value="P:acetylcholine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019695">
        <property type="term" value="P:choline metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00312">
        <property type="entry name" value="Esterase_lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000029">
        <property type="entry name" value="Acetylcholinesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000997">
        <property type="entry name" value="Cholinesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF13">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00878">
        <property type="entry name" value="CHOLNESTRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0531">Neurotransmitter degradation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="5" id="KW-0770">Synapse</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="12">
        <location>
            <begin position="25"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="10">
        <location>
            <position position="220"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="10">
        <location>
            <position position="344"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="10">
        <location>
            <position position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR600997-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAB0802766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="554" mass="62440" checksum="46C19A4CE237ACF2" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B0P7</accession>
    <name>A0A5N4B0P7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MADF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_00137</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B0P7"/>
    <dbReference type="FunCoup" id="A0A5N4B0P7">
        <property type="interactions" value="42"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4B0P7"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039353">
        <property type="entry name" value="TF_Adf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243">
        <property type="entry name" value="MADF DOMAIN TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243:SF60">
        <property type="entry name" value="SI:CH211-15D5.12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00595">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51029">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MADF" evidence="2">
        <location>
            <begin position="5"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0803167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="241" mass="27465" checksum="3F6BC220C6C7602C" modified="2020-02-26" version="1">MEDGELIDQVRLFSHLYDKSNKLYKDSSAIKNAWETISHVLGSTVEDCQRRWAVLRARFNAERKKYTPSGAAGDTSSWVYFNAMSFLTEHVTQRRTKRNIPAATSSCAAEKQKLNPWESFSIMIEGESEEFEEDPHVNLLSPTSSMSRTSTLTQQSAPSPTERPTKAKSQKKVDENVNKTIQQAMGTLDGYMTSKAHQPTMPTEEDRDMCFGKMVGLELKEIKDENKKKELKRQILQILYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B0W3</accession>
    <name>A0A5N4B0W3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MULE transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_00020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B0W3"/>
    <dbReference type="InParanoid" id="A0A5N4B0W3"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018289">
        <property type="entry name" value="MULE_transposase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47160:SF10">
        <property type="entry name" value="MULE TRANSPOSASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47160">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10551">
        <property type="entry name" value="MULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MULE transposase" evidence="1">
        <location>
            <begin position="137"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0803050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="416" mass="47896" checksum="4AF31CD3A72464A8" modified="2020-02-26" version="1">MENMGYGCANSDQAARVEPAAIRLVTTVKERAATTQESPHQIIANVIPQAHADVAAIMPKKDALKKTIRRARRDEEAPALPRNMQELVIPRGFSEIVIDGEVQQFLMYDSENQLMPGRILIFSTRSNLHLLAQSQEWFADGTFSTAPAIFEQLYTLHAIKNSAVVPLVYALLPNKTRATYVTFLQQLKRLQPGLQPTQLMTDFELAAMQAFELEFPGILKTGCFFHLSQSVWRKVQSEGPKARYENDHEFARWIRMIPALAFVPEHNVSDSFTELLETEGFPEEAVPIANYFEDTYIGRRLRRGRQIPLFPTQIWNVYQRTLNDQHRTNNHVEGWHRAFQETCGSQFPNIFRFIECLRKQQGIHNYEIIQSIAGNQGNPRNKKYVAISARIKRIVEDFEDRHLTDYLHGIAYNFEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B0X4</accession>
    <name>A0A5N4B0X4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MADF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_00030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B0X4"/>
    <dbReference type="InParanoid" id="A0A5N4B0X4"/>
    <dbReference type="OrthoDB" id="6617753at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21505:SF8">
        <property type="entry name" value="DPT-YFP REPRESSOR BY OVEREXPRESSION, ISOFORM D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21505">
        <property type="entry name" value="MADF DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00595">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51029">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MADF" evidence="2">
        <location>
            <begin position="14"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0803060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="334" mass="38258" checksum="A52727909884E182" modified="2020-02-26" version="1">MADSRYWSKEIVANFIEIYKGHPCLWKVKSKDYTNKNLKNLAYDKLVDFCKTFNTEANRDYVIKKIQSFRGSFRKELKKLLQSKRSGAGVPDVYEPTLWYYDLLLFTCDQEIPNASVQSNMSHDETVVDNNSQDDEEEENQDTQLSEHTEWETDELVEERRENKSNKDLLLTENDNASNSTPKSAYSSGMKSLSTTPRQKKKTTIKKRNEEFMEFCKQQLQAHNDIDEYDAVGISWAKKLKRMNPEQAVYAESLINSIVSRGLLNKLSDAVTLSDANEQRPASSSSSYTLNSSDSRQCWQVTLPCEDAPQPPVVVPSSSLVEYYTSIANINTNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B1R2</accession>
    <name>A0A5N4B1R2_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_00495</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B1R2"/>
    <dbReference type="InParanoid" id="A0A5N4B1R2"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024337212" evidence="2">
        <location>
            <begin position="19"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0803525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="71" mass="7001" checksum="C157A243A9311186" modified="2020-02-26" version="1" fragment="single">AYIVVVIAMLCITQLAFGEAIPDHHSGHHGGGSHHGGGGHHGGEGHHGGGSHHGGGGHHGGGGHHGHKNHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B2G2</accession>
    <name>A0A5N4B2G2_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nematode cuticle collagen N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_00550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B2G2"/>
    <dbReference type="InParanoid" id="A0A5N4B2G2"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.320">
        <property type="entry name" value="6-Phosphogluconate Dehydrogenase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637">
        <property type="entry name" value="COLLAGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637:SF421">
        <property type="entry name" value="CUTICLE COLLAGEN DPY-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="145"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0803580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="333" mass="36798" checksum="A9358C5109A724FD" modified="2020-02-26" version="1">MLDVEDEKPITPKTVIKVALLLGSLILVQVAVAIYSYRLLKTEIENDIHRQIDLEYNKLLRDIKEIEIKDVDKQRFYGTDILDRRKRGDDGDIAQICKTIEQSCPIRGPPGFPGMPGLPGQKGQPGYPGYPGPQGQKGDQGERGLPGAPGLMGPPGNEQLSEAFVTMGAEVKTDSNNYSFYIVLLLVIILLSQIFIGLYSYKILRRDVIRTVENNLEISKRDILKVIENYESVGDGELLHRSKREAEGSGDDSEDSENEYEIEDIELFCNKVNDNCVQRGPVGPPGRVGLIGIKGERGQPGIPGPMGIPGMYISSSAISMWGIISSNFKVHRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-09-13" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B3Q1</accession>
    <name>A0A5N4B3Q1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_01166</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B3Q1"/>
    <dbReference type="InParanoid" id="A0A5N4B3Q1"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0804196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="234" mass="27400" checksum="683841F8C980558F" modified="2020-02-26" version="1">MFNYQLSRVIIAGDFNIKFNLKDKFATMFCDLLSTFGYSQTIFSATREGNCLDNIFINFDTTSIETSVPETGLSDHLGQTITIPKIFLEYINDNKIVNTSFRSITAKGSYLLYMLLTSCNWDFLDSHELSCDIMFDTFFKKFIDAFVVAFPFKKCYVRSRDNKVVWFNEKLKRIRDRVAFINDVYRVDKSYFVQREKKRLRMEYRYAIKTAKCLANDNFISNSSNPGKAAWQFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B3V9</accession>
    <name>A0A5N4B3V9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PPYR_01030</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B3V9"/>
    <dbReference type="InParanoid" id="A0A5N4B3V9"/>
    <dbReference type="OrthoDB" id="3026777at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF1">
        <property type="entry name" value="FI18259P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="230"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="294"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="331"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="362"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="389"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="420"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="454"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0804060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="491" mass="55485" checksum="69D42473AF2F7E05" modified="2020-02-26" version="1">MYQSTMQSINQAEEQDKTPATFCVRVRSILSLVTVEPLMFLFVFPSMLLTLSIVNLHMDKACRVNLQLNASVCDGLSQRNSSMYTSEEENMVQRMVANMNMWKAVIQSVLPPCLLLMLGAWSDKHNRRKLLMGFPIVGEVITVTGFILCTYFFYELPMEVTGVVESLPTSATGGWFVMFMAVYSYVGAVSTLESRTLRIGALKICATGSIMVGTAMSGICYRLIGLYGIFSTALFLFVVGLIYTVLVIREVGTAAPQANKSTYTSYKDFFNYQHMKSTFYFAFKRRDGNRRARMFVSFVLLCLTFGPVQGETSVVYLFIRKRFQWSEVEFSILFSIKIVLHLVGTVLPLLILSKYLKMDDTVIGMICYLGKFVSGFLCAFSTSPLMYCIGMVVEMFSPTTFITVRSIGTKLVSVEEQGRLNALNSIFEALIPLGFVSVYNFVYKKTIDFFPGTFYIVSSLTCIPTMILLGWLYLQRKHDIEEDKMHEQSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B4L4</accession>
    <name>A0A5N4B4L4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Odorant receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PPYR_01527</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cell membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B4L4"/>
    <dbReference type="FunCoup" id="A0A5N4B4L4">
        <property type="interactions" value="15"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4B4L4"/>
    <dbReference type="OrthoDB" id="7545962at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="119"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="165"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="363"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU351113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0804557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="391" mass="44667" checksum="E4203B95729957AC" modified="2020-02-26" version="1">MAISLNSNAFKIQKRLMIMTGLWPRRDSGTLYRIYGASHYWLLATFSLSLLLSTMVVKDFSQLIQGWSMFVAILNCVIKFTIFYFKMPVFLDLLDFLHSPHFSYHKDEVDHHLKRIIDFAIAVVKLFLCSCVTTVFCMITTPLFASKGTRLTPLPFPLDFEKHSFLTYISVYLYQCLGLASACCSSIGFDNLSTSMMGLCSAYFAILTETIISTTNEFQKKANENHIRSYEKFDEQVYSDLSQCVEHHLAVIKFTETIENIFSYVFLSQFLCSAFGICLAGFTSINAKPGSVEFIFALSFLGTLMFQITLYCSYGNEVTIQSYRVLEACYMTEWVYRGPKVRQNLFLIMERSKRPMVMTAGKFVNLSLSSLVSVFRSAASYAMVLYQLYNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-06-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B674</accession>
    <name>A0A5N4B674_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_02024</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0805054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B674"/>
    <dbReference type="InParanoid" id="A0A5N4B674"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0805054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="157" mass="18549" checksum="EB058C91C9C80197" modified="2020-02-26" version="1">MRLLVSLPTGKHIESFTELMRSNLSISLDAESWMIFRIFSFISNDVPIKELKQPLRKNDDPYNLTKSWYADKSFVFDMLLKTLQSIELRLQVSPPPYFVDTELFPTITNVFVSEKCFYFIDSLDVFIDRLTESGLYDKLEQDRKFYAEKEKSKFISE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B675</accession>
    <name>A0A5N4B675_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PPYR_02028</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0805058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B675"/>
    <dbReference type="FunCoup" id="A0A5N4B675">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4B675"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF258">
        <property type="entry name" value="PROTEIN ALP1-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="DDE Tnp4" evidence="9">
        <location>
            <begin position="179"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0805058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="408" mass="46570" checksum="FBDB5B7A28975626" modified="2020-02-26" version="1">MNRNLIASSALAASVIVIMSCLLTKRRNKRTRIWSRNWLQRRNEGRDVLNMLNTELLPEDPNAYTNFLRLTNDQFEYLLSLISNEICKQDTLMRECIPSRSKLEVTLRFLATGETYRSLMYTTRIHETTISRFIPEVCQAIVLKLKPIYLKAPRTAEEWKKISQDFDQLWQFPHCVGALDGRHITFRAPISAGSYYYNYKGANSIVLLALAAANYKFIYANIGVNGRISDGGVFQNSSLSRALQDNSLSLPAPEVLPGMTEALPYVIVADDAFPLSKNLLKPYPDRGLGNDSRIFNYRLSRARRIIENSFGILANRFRLLLNPVNLDAEKVELITLTCVVLHNFLATDNAQSYIELEEFNENLPKINRQCGNRTSIAARDIPDHFRSYFNSSQGSVPWQQNAINNFNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B6P0</accession>
    <name>A0A5N4B6P0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Hydin adenylate kinase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_02198</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0805228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B6P0"/>
    <dbReference type="InParanoid" id="A0A5N4B6P0"/>
    <dbReference type="OrthoDB" id="10262413at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22967">
        <property type="entry name" value="DD_AK7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.890.10">
        <property type="entry name" value="cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047499">
        <property type="entry name" value="DD_AK7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007858">
        <property type="entry name" value="Dpy-30_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033768">
        <property type="entry name" value="Hydin_ADK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051783">
        <property type="entry name" value="NAD(P)-dependent_oxidoreduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079:SF6">
        <property type="entry name" value="NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079">
        <property type="entry name" value="PROTEIN YEEZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05186">
        <property type="entry name" value="Dpy-30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17213">
        <property type="entry name" value="Hydin_ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydin adenylate kinase-like" evidence="3">
        <location>
            <begin position="433"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="487"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="577"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="696"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="98"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="496"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="579"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0805228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="836" mass="96661" checksum="7F7C60F42C2EB415" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1JVF1</accession>
    <name>A0A1Y1JVF1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Lysosomal-associated transmembrane protein 4B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PPYR_13640</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LAPTM4/LAPTM5 transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01102829">
        <property type="protein sequence ID" value="JAV51770.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0794020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1JVF1"/>
    <dbReference type="FunCoup" id="A0A1Y1JVF1">
        <property type="interactions" value="294"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1JVF1"/>
    <dbReference type="OrthoDB" id="10002163at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004687">
        <property type="entry name" value="LAPTM4/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051115">
        <property type="entry name" value="LAPTM_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12479">
        <property type="entry name" value="LYSOSOMAL-ASSOCIATED TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12479:SF10">
        <property type="entry name" value="LYSOSOMAL-ASSOCIATED TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03821">
        <property type="entry name" value="Mtp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="184"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="280"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="292"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="319"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
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        </source>
    </evidence>
    <sequence length="335" mass="37666" checksum="6FCB509112E9BE7A" modified="2017-08-30" version="1">MFPMRLKMGPGRNSEWRCFFCLHVRTATVLLGIWHLILHVLALSVLAIIMRNHQQLMVEQQTTPDYVEPNNLLPTPLSKVKDNDNPYFLPTTQDGRTLYSSDMDMGALMTVCTLAITLLLVYGTLKGRATHLLPFFCLQLFDFAITTLTATGYFCYLRSVHSLVADHWHNLPFRKELLQLSPQYLSLIVLIAFLISMLWKAYCIGIVWRCYKFLTLRKQAMRSTVHYILPGEGSDRLPEPDYSSLLPDYEAACASVLKQPPPPSYAVAMSCLPPAYSNTQISADGTPAENEPATTEPNQITQSVIVENENKDEEVAPQGNVTSQVVVESANVHQN</sequence>
</entry>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
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                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
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        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
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        </source>
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    <reference evidence="3" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
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    </dbReference>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="318" mass="36705" checksum="AB2E63934FA40429" modified="2017-08-30" version="1">MKLQEKQNQLLIKAELTELNEEFLKFGHNLHELKYAIRNESTSLNRKLISVLISVSIVIFCICYQCGIFDILSRHALGVRCIIPNNYFVWEATRPISDCQFCTNVTEPILLYNATREEFSKYAFSSKPIVIKRALLHWPAVKVFSFEFFKNLYNSLDDAYRSVDEECQFLHFRSNFISLRDVFAMSEARSNNAPGETPWYVGWGNCDPDVLEVMRKYYPKPHFLPADSELSAKEYVFMGYDAGATMHLDFINRLMWQAQLQGTKTWHLKPSPECETVCHSLTFLAEPGDAVLIDTRVWYHGTTIAPGEFSLAIQSEYG</sequence>
</entry>
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    <name>A0A1Y1K4K0_PHOPY</name>
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            <fullName evidence="6">BHLH domain-containing protein</fullName>
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        <name type="scientific">Photinus pyralis</name>
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    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
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                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
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                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
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    <reference evidence="8" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
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    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
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                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="24 26" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">1611_PpyrPB1</strain>
            <tissue evidence="24">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="24">1611_PpyrPB1</strain>
            <tissue evidence="24">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>3-O-(5'-adenylyl)-L-threonyl-[protein] + H2O = L-threonyl-[protein] + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:55932"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13847"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:138113"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-threonyl-[protein] + ATP = 3-O-(5'-adenylyl)-L-threonyl-[protein] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:54292"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13847"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:138113"/>
            <dbReference type="EC" id="2.7.7.108"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-tyrosyl-[protein] + ATP = O-(5'-adenylyl)-L-tyrosyl-[protein] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:54288"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:13846"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:83624"/>
            <dbReference type="EC" id="2.7.7.108"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fic family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.108" evidence="15"/>
    <dbReference type="EMBL" id="GEZM01083370">
        <property type="protein sequence ID" value="JAV61122.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0798827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1KI47"/>
    <dbReference type="FunCoup" id="A0A1Y1KI47">
        <property type="interactions" value="248"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1KI47"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070733">
        <property type="term" value="F:AMPylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3290.10">
        <property type="entry name" value="Fido-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003812">
        <property type="entry name" value="Fido"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036597">
        <property type="entry name" value="Fido-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040198">
        <property type="entry name" value="Fido_containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13504">
        <property type="entry name" value="FIDO DOMAIN-CONTAINING PROTEIN DDB_G0283145"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13504:SF34">
        <property type="entry name" value="PROTEIN ADENYLYLTRANSFERASE FICD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02661">
        <property type="entry name" value="Fic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140931">
        <property type="entry name" value="Fic-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51459">
        <property type="entry name" value="FIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fido" evidence="22">
        <location>
            <begin position="260"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="active site" evidence="19">
        <location>
            <position position="338"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="291"/>
            <end position="294"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="342"/>
            <end position="349"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="374"/>
            <end position="375"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for autoinhibition of adenylyltransferase activity" evidence="21">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR640198-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR640198-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR640198-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="JAV61122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KAB0798827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="KAB0799000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="418" mass="47203" checksum="D267DF43689CB2CD" modified="2017-08-30" version="1">MTIISLIICLLIGIVCVLAILLQAIYNRFIYIKGCVEAPSILEDMMVIDYANKSEVSHLLKRVASDGLVTLRNKHFVTYTEMLHLLEAALAFKLSGNVGKAAKLLDRATSVALQSPDVLNRYGEFIEHVHNDIVAADLLYYKALTYCPNHKGALDNRKRSAPIVEKLDLEMLALIDKKRNLLQERQKTSAVYSAMKRKMYYLQIYHTVGLEGNTLTLDQIVSLLETGLAVQGKSLIEHNEILGVELAMNYVKLLIRYPTISTKEIQAVHSRVLGHVDPVSAGKLRREQVFVGSHVPPEPEDVPFLLEGYAYWLNSDAAHSLHPVKYAALAHYKLVDIHPFMDGNGRISRLIMNLVLLRTGYPPILIFKYQRDKYYQSLNLADRGDVCLFVRFIAECMKSSLELYLSNVEYMAGITHLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1KP05</accession>
    <name>A0A1Y1KP05_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Rootletin-like coiled-coil domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PPYR_04638</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01080366">
        <property type="protein sequence ID" value="JAV62191.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A1Y1KP05">
        <property type="interactions" value="25"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1KP05"/>
    <dbReference type="OrthoDB" id="3549872at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000793">
        <property type="term" value="C:condensed chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055167">
        <property type="entry name" value="Rootletin-like_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43941">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43941:SF1">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15035">
        <property type="entry name" value="Rootletin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rootletin-like coiled-coil" evidence="4">
        <location>
            <begin position="63"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="100"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="374"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1722"/>
            <end position="1758"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1899"/>
            <end position="1926"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="138"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="280"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="414"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="498"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="827"/>
            <end position="1244"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1270"/>
            <end position="1318"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1374"/>
            <end position="1401"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1758"/>
            <end position="1850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="102"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1722"/>
            <end position="1732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1742"/>
            <end position="1758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1899"/>
            <end position="1915"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF15035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="JAV62191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0802452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1926" mass="223954" checksum="311805945CCEBDC6" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1KS37</accession>
    <name>A0A1Y1KS37_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Lipase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PPYR_07347</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01075353">
        <property type="protein sequence ID" value="JAV64124.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1KS37"/>
    <dbReference type="InParanoid" id="A0A1Y1KS37"/>
    <dbReference type="OrthoDB" id="9974421at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000057">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006693">
        <property type="entry name" value="AB_hydrolase_lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025483">
        <property type="entry name" value="Lipase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11005">
        <property type="entry name" value="LYSOSOMAL ACID LIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04083">
        <property type="entry name" value="Abhydro_lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000862">
        <property type="entry name" value="Steryl_ester_lip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033750342" description="Lipase" evidence="9">
        <location>
            <begin position="25"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="Partial AB-hydrolase lipase" evidence="10">
        <location>
            <begin position="53"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="362"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000862-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="JAV64124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAB0799467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="421" mass="48242" checksum="D3AC2A9938F2FB70" modified="2017-08-30" version="1">MKRITILSVFIALISLLLIPRSKNNVCKSFSDYYGDRDKNENCYYNPDTYMNVSQIIKQRGYPVEEHDVTTKDGYILTLFRIPLGKNSSTLLSGRPILILHGVLTNSASFVNRGNKSLAFLLADAGYDVWLGNFRGTVYGKKHTQLKNTDRLFWEFNTYELGVYDIAAKIDHIYSITKQKITYLGFSFGSTAGYMYSVTNPSLAEEKIRIIISLAPTVFLSNWKSITKYFIQFWPYTEPFFTFFTNGEVALRGTYQSKLREMLCLPYPFQMYLCQLMDMIAMGFDYEQNDPETLPVTLLQNSDATSYKTISHGLQLVSKGNFDYLDYGSEELNMAAYGSPEVPKHNLSRLSVPTYLVTAINDMMITVEDVKLLHEHLPKKVNPYDLYIVKHEAFNHDDFIAARDVVPLVYNPLVNFINNLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1KU60</accession>
    <name>A0A1Y1KU60_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sulfhydryl oxidase</fullName>
            <ecNumber evidence="9">1.8.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PPYR_10886</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + H2O2</text>
            <dbReference type="Rhea" id="RHEA:17357"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:16520"/>
            <dbReference type="ChEBI" id="CHEBI:17412"/>
            <dbReference type="EC" id="1.8.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="1.8.3.2" evidence="9"/>
    <dbReference type="EMBL" id="GEZM01077596">
        <property type="protein sequence ID" value="JAV63255.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1KU60"/>
    <dbReference type="FunCoup" id="A0A1Y1KU60">
        <property type="interactions" value="1287"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1KU60"/>
    <dbReference type="OrthoDB" id="17199at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016971">
        <property type="term" value="F:flavin-dependent sulfhydryl oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.310:FF:000003">
        <property type="entry name" value="Sulfhydryl oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.310">
        <property type="entry name" value="ERV/ALR sulfhydryl oxidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039799">
        <property type="entry name" value="ALR/ERV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036774">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017905">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12645">
        <property type="entry name" value="ALR/ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12645:SF0">
        <property type="entry name" value="FAD-LINKED SULFHYDRYL OXIDASE ALR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04777">
        <property type="entry name" value="Evr1_Alr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69000">
        <property type="entry name" value="FAD-dependent thiol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51324">
        <property type="entry name" value="ERV_ALR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 9" id="KW-0274">FAD</keyword>
    <keyword evidence="3 9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERV/ALR sulfhydryl oxidase" evidence="10">
        <location>
            <begin position="55"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU371123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51324"/>
        </source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
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    </evidence>
    <sequence length="166" mass="19265" checksum="6DF94609E9250214" modified="2017-08-30" version="1">MHRSSPLDSENCRSCTSFSDYFKSTKAKLKAEQNANELSNKSSNEMMEKPIRLDCPLDKDELGNATWGLLHTMASKYPDQPNEEQKRDMKQFFNLLGKFYPCEYCAKDLRKDLKVDPPNVENQTALSQWLCKLHNKVNIKIGKPEFDCSKVNERWRDGWLDGSCDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
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        <name evidence="3" type="ORF">PPYR_01158</name>
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        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
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    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
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                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </reference>
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        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
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        <property type="molecule type" value="Transcribed_RNA"/>
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        <property type="protein sequence ID" value="KAB0804188.1"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
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    <organism evidence="13">
        <name type="scientific">Photinus pyralis</name>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
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            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
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                <person name="Al-Wathiqui N."/>
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                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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            <tissue evidence="14">Whole body</tissue>
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    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
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        </subcellularLocation>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Znf_C2H2_type"/>
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        <property type="entry name" value="KLUMPFUSS, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
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        <property type="match status" value="14"/>
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        <property type="match status" value="5"/>
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        <source>
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        <source>
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    </evidence>
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        <source>
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1L4D3</accession>
    <name>A0A1Y1L4D3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Multiple inositol polyphosphate phosphatase 1</fullName>
            <ecNumber evidence="4">3.1.3.62</ecNumber>
            <ecNumber evidence="3">3.1.3.80</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">2,3-bisphosphoglycerate 3-phosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PPYR_13267</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">1611_PpyrPB1</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">1611_PpyrPB1</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(2R)-2,3-bisphosphoglycerate + H2O = (2R)-2-phosphoglycerate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:27381"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58248"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="EC" id="3.1.3.80"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:27382"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>1D-myo-inositol 1,2,4,5,6-pentakisphosphate + H2O = 1D-myo-inositol 1,2,5,6-tetrakisphosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:77115"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57798"/>
            <dbReference type="ChEBI" id="CHEBI:195535"/>
            <dbReference type="EC" id="3.1.3.62"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:77116"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>1D-myo-inositol 1,2,5,6-tetrakisphosphate + H2O = 1D-myo-inositol 1,2,6-trisphosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:77119"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:195535"/>
            <dbReference type="ChEBI" id="CHEBI:195537"/>
            <dbReference type="EC" id="3.1.3.62"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:77120"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>1D-myo-inositol hexakisphosphate + H2O = 1D-myo-inositol 1,2,4,5,6-pentakisphosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16989"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57798"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="EC" id="3.1.3.62"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:16990"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histidine acid phosphatase family. MINPP1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.62" evidence="4"/>
    <dbReference type="EC" id="3.1.3.80" evidence="3"/>
    <dbReference type="EMBL" id="GEZM01066909">
        <property type="protein sequence ID" value="JAV67658.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1L4D3"/>
    <dbReference type="FunCoup" id="A0A1Y1L4D3">
        <property type="interactions" value="137"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1L4D3"/>
    <dbReference type="OrthoDB" id="6509975at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034417">
        <property type="term" value="F:bisphosphoglycerate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052745">
        <property type="term" value="F:inositol phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963:SF8">
        <property type="entry name" value="MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963">
        <property type="entry name" value="MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033750238" description="Multiple inositol polyphosphate phosphatase 1" evidence="15">
        <location>
            <begin position="24"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="31"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="372"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="112"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="396"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="428"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00043668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00043671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00043691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00043832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="JAV67658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAB0793647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="711" mass="82939" checksum="8D48623334810767" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2024-01-24" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1L9G7</accession>
    <name>A0A1Y1L9G7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TGF-beta propeptide domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_03680</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01065053">
        <property type="protein sequence ID" value="JAV68575.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1L9G7"/>
    <dbReference type="InParanoid" id="A0A1Y1L9G7"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001111">
        <property type="entry name" value="TGF-b_propeptide"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00688">
        <property type="entry name" value="TGFb_propeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033750354" description="TGF-beta propeptide domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="TGF-beta propeptide" evidence="2">
        <location>
            <begin position="190"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="JAV68575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0791880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="465" mass="52570" checksum="45EE1B9C92FAF3A6" modified="2017-08-30" version="1">MPLDFVLLLLLALLLRTRAMPVDFDDKVKFENAPEIEKNLVDYLNWYYDTYMVAGANHEVQENGVENEDIYEKMQSDQAPPADFGQLNKPMYVNLSSIVNLTSENQSDEYHRIMRNRTKDAWIQILKNNILRHVGRTNSSTSKPPNGFDVPGLNMSKIIPDLLPLPDDSVDDVTEKIRSYYPSCELPKNTDQDLWKDENTMNLYFNVEHPDSSSINVATATLRLYRVPAGNVTSTTTDSCENSTGSEEQLMRISIYWYTKSLKRQRVKRRLSDSKVIAQSAKWVELSVLPATKAWMKGKNLGLAILVEDQEGAVLKADKYFKGASCMVGTSTPKPIPTVIVDAARWANELERINGSPGRNTTTAFFNHLSLLPTVDICTLEFPQNSTHDTAANYKGNVCDLKRVHQKPVNADAPGALPTSRHIRHQKHNMDPRSRMVGQRLVLTSEEMRNLNAHLANSTYPSIQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1L9J0</accession>
    <name>A0A1Y1L9J0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HOOK N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_03903</name>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="JAV69350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0799021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0799846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="324" mass="36197" checksum="7B70B65847DA7B8C" modified="2017-08-30" version="1">MWVYFLFSCLTLTAAVLIRLKVIKVRTRWDRSPTCLVGKTAIVTGANCGLGFYTAQDLAKRGARVILACRSRERAEAARRQIVRATHNQNVHVRIVDFASLKSVREFAKEINSSEERLDILVNNAGALIFEDDVTEDGLSKFMQVNHFGPFLLTELLIDLLKKSKPSRIVYVSSSSVTHGQIHLDNLNYSANSRIARLTFSNYANSKLCHLATTNELAKRLRGSGITVNSLDPGTVRTEVTRNLNIMTQGLFRILASFFKISEEGAQTSIYLAVSDDVQDVTGKYFYNCALSEMPSTAIDSTLNRKVWEKSAELVHLTHTESTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LFP8</accession>
    <name>A0A1Y1LFP8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ubiquitin-conjugating enzyme E2 Z</fullName>
            <ecNumber evidence="3">2.3.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">E2 ubiquitin-conjugating enzyme Z</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Ubiquitin carrier protein Z</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Ubiquitin-protein ligase Z</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PPYR_05084</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">1611_PpyrPB1</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">1611_PpyrPB1</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="3"/>
    <dbReference type="EMBL" id="GEZM01057089">
        <property type="protein sequence ID" value="JAV72454.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1LFP8"/>
    <dbReference type="InParanoid" id="A0A1Y1LFP8"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:cysteine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="UBCc_UBE2Z"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46116">
        <property type="entry name" value="(E3-INDEPENDENT) E2 UBIQUITIN-CONJUGATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46116:SF26">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2 Z"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="16">
        <location>
            <begin position="22"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00039894"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00041798"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00042316"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00042401"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="JAV72454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAB0802898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="275" mass="30922" checksum="88576FD288C0FE98" modified="2017-08-30" version="1">MPMPKPEWDPTDSADGGTLSFTASTRIKRDLRCIFNDPPAGIFVVGDESNLRIVHAIIFGVVDTPYEGGFFYFILRCPNDYPIHPPKVKLMTTNAGRVRFNPNLYKSGKVCLSILGTWEGPAWSPALQLSSLLISIQSLLCENPYFNEPGFVKEHVPGDSKRYNEYIRHETLRVAVCGMIENECHLNIPSKLREIMEKTFLEFYDQYVEIIKANIHLHGTELIDPFSKGRFVCQYKALLTRLEKIKGNLMPQSESVSKQASCSSAGDNGNEGNLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LJQ3</accession>
    <name>A0A1Y1LJQ3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">SRP54-type proteins GTP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PPYR_07269</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GTP-binding SRP family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01057672">
        <property type="protein sequence ID" value="JAV72165.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1LJQ3"/>
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    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1LJQ3"/>
    <dbReference type="OrthoDB" id="1727884at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005785">
        <property type="term" value="C:signal recognition particle receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005047">
        <property type="term" value="F:signal recognition particle binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14826">
        <property type="entry name" value="SR_alpha_SRX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17876">
        <property type="entry name" value="SRalpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000015">
        <property type="entry name" value="Signal recognition particle receptor subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000188">
        <property type="entry name" value="signal recognition particle receptor subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="entry name" value="Signal recognition particle SRP54, nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRP54-type proteins GTP-binding" evidence="9">
        <location>
            <begin position="596"/>
            <end position="609"/>
        </location>
    </feature>
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        <location>
            <begin position="154"/>
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        <location>
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        </location>
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        <location>
            <begin position="179"/>
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    </feature>
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        <location>
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        <location>
            <begin position="237"/>
            <end position="247"/>
        </location>
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        <location>
            <begin position="279"/>
            <end position="292"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="JAV72165.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAB0799389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="623" mass="69837" checksum="80E7DAFE7AB52D22" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LQ39</accession>
    <name>A0A1Y1LQ39_PHOPY</name>
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        <recommendedName>
            <fullName evidence="9">Trafficking protein particle complex subunit</fullName>
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    </protein>
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        <name evidence="7" type="ORF">PPYR_03420</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
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        <subcellularLocation>
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        </subcellularLocation>
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        <text evidence="2">Belongs to the TRAPP small subunits family. Sedlin subfamily.</text>
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    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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    </dbReference>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006626"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="JAV74025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0791620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="146" mass="17519" checksum="60B3086829B6AB58" modified="2017-08-30" version="1">MPKKSEQMSASYYFVIVGHRDNPIFEVEFTNVKEPKKEDHRHLNQFIAHAALDLIDEHKWKTHNMYLKSVDKFNQWFVSAFITASHIRFVMVHDNKNEDGIKNFFNDIYELYIKHSMNPFYEEDKPIKSSVFEKKAQFYGKKYLSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1M0X6</accession>
    <name>A0A1Y1M0X6_PHOPY</name>
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        <recommendedName>
            <fullName evidence="12">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="14" type="ORF">PPYR_07843</name>
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    <organism evidence="13">
        <name type="scientific">Photinus pyralis</name>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
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            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
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                <person name="Al-Wathiqui N."/>
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                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GEZM01045043">
        <property type="protein sequence ID" value="JAV77955.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="E3 ubiquitin-protein ligase RNF128"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="E3 ubiquitin-protein ligase RNF130"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46539">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE ATL42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46539:SF23">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZF_RING_2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033750368" description="RING-type domain-containing protein" evidence="11">
        <location>
            <begin position="24"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="223"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="291"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="397"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="JAV77955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAB0799963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="481" mass="53620" checksum="9C3F1345ADC7EAF7" modified="2017-08-30" version="1">MDFSWNRTVFIVTFSQIIAIVSSTSGPEDFPIGAALQLSPGDDARSFDDEIPNSFTSAYVNVTYKDSANTWKWERTEVGRYGGGYVGPAFGVVVHVTADNDPSDHSGCRLPFRSSRGDRQLPKPGEPWIALIKRGHCNFESKVDNAFKSKATGVLVYNDRDSVDLDKMKLSNDNDRNISAVFTYKWKGEEIAKLLENDTKVLVHMTIASRSTSPSATINRTSVLFVSVTFIVLMIISLAWLVFYYVQRFRYIHAKDRLSKKLCNAARKALSKIPTKNIKSDDNEVQEGECCAICIEPYKISEVLRMLPCHHEFHKSCIDPWLLEHRTCPMCKMDILRHYGFMFTGSQESILHMEIDEVVGLGSNESQDSDSPRHGGVSPLPQIRTVVLTDRRRSFGSSIDVEERSSRASTPDEMTPSLATRPVRPDLCANCIAAAASLAAQDETKTVKSIVQQVLTSENVTDSAQVQIGDNTDSDSKVLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1M837</accession>
    <name>A0A1Y1M837_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PPYR_02924</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMEK family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01037657">
        <property type="protein sequence ID" value="JAV81999.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01037654">
        <property type="protein sequence ID" value="JAV82002.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1M837"/>
    <dbReference type="FunCoup" id="A0A1Y1M837">
        <property type="interactions" value="2454"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1M837"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030289">
        <property type="term" value="C:protein phosphatase 4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072542">
        <property type="term" value="F:protein phosphatase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Serine/threonine-protein phosphatase 4 regulatory subunit 3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055236">
        <property type="entry name" value="EVH1_PP4R3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006887">
        <property type="entry name" value="P4R3-like_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051137">
        <property type="entry name" value="PP4R3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23318">
        <property type="entry name" value="ATP SYNTHASE GAMMA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23318:SF0">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 4 REGULATORY SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22972">
        <property type="entry name" value="EVH1_PP4R3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PP4R3 EVH1-like" evidence="6">
        <location>
            <begin position="5"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Serine/threonine-protein phosphatase 4 regulatory subunit 3-like central" evidence="5">
        <location>
            <begin position="145"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="756"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="761"/>
            <end position="773"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF22972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="JAV81999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0791124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="782" mass="90302" checksum="9541B416A07558E0" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1M8D0</accession>
    <name>A0A1Y1M8D0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Lethal giant larvae homologue 2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_13037</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat L(2)GL family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01042812">
        <property type="protein sequence ID" value="JAV79575.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01042810">
        <property type="protein sequence ID" value="JAV79577.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1M8D0"/>
    <dbReference type="FunCoup" id="A0A1Y1M8D0">
        <property type="interactions" value="440"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1M8D0"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045159">
        <property type="term" value="F:myosin II binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030866">
        <property type="term" value="P:cortical actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051294">
        <property type="term" value="P:establishment of spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032878">
        <property type="term" value="P:regulation of establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008593">
        <property type="term" value="P:regulation of Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10241">
        <property type="entry name" value="LETHAL 2 GIANT LARVAE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10241:SF29">
        <property type="entry name" value="LETHAL(2) GIANT LARVAE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08366">
        <property type="entry name" value="LLGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00962">
        <property type="entry name" value="LETHAL2GIANT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Lethal giant larvae homologue 2" evidence="7">
        <location>
            <begin position="261"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="439"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="640"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="982"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1059"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="673"/>
            <end position="695"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="JAV79577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0793417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1081" mass="118676" checksum="839AEC3E66E1D8B8" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1M8P0</accession>
    <name>A0A1Y1M8P0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">BOS complex subunit TMEM147</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Transmembrane protein 147</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PPYR_07428</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the TMEM147 family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01037116">
        <property type="protein sequence ID" value="JAV82159.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1M8P0"/>
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    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1M8P0"/>
    <dbReference type="OrthoDB" id="9993532at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019164">
        <property type="entry name" value="TMEM147"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12869:SF0">
        <property type="entry name" value="BOS COMPLEX SUBUNIT TMEM147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12869">
        <property type="entry name" value="SMALL SEVEN TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09767">
        <property type="entry name" value="DUF2053"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="141"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="196"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="JAV82159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAB0799548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="227" mass="25317" checksum="202BBD512F7287FA" modified="2017-08-30" version="1">MTLYHFGNCIALIYVPYYLTYKYSGLSEYGAFWKCIQAGCVYMFTQLAKMLILATFFPDNESDLGGDFVGEFLKSTVDLADLVGLYMVLGSIPGKGHSKVLTAGVGWATAEVILSRALLLWVGARGAEFDWKYIHKCLESNIALVQHISTVTLIWLWTRHDLPLNFKPVVTALLLFSSFKPFLLETLFKFLITGPWVVIFVKALVTVSVSVFTLIIYAGLAQSIGIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1MDM5</accession>
    <name>A0A1Y1MDM5_PHOPY</name>
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        <recommendedName>
            <fullName evidence="4">General transcription and DNA repair factor IIH helicase subunit XPD</fullName>
            <ecNumber evidence="18">5.6.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">CXPD</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">DNA 5'-3' helicase XPD</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">DNA excision repair protein ERCC-2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="23">DNA repair protein complementing XP-D cells</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="24">Xeroderma pigmentosum group D-complementing protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">PPYR_13908</name>
    </gene>
    <organism evidence="26">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="27 28" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">1611_PpyrPB1</strain>
            <tissue evidence="27">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="27" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="27">1611_PpyrPB1</strain>
            <tissue evidence="27">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the helicase family. RAD3/XPD subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="18"/>
    <dbReference type="EMBL" id="GEZM01036437">
        <property type="protein sequence ID" value="JAV82700.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0791947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1MDM5"/>
    <dbReference type="FunCoup" id="A0A1Y1MDM5">
        <property type="interactions" value="1702"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1MDM5"/>
    <dbReference type="OrthoDB" id="272481at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035315">
        <property type="term" value="P:hair cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045951">
        <property type="term" value="P:positive regulation of mitotic recombination"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18788">
        <property type="entry name" value="SF2_C_XPD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA repair helicase RAD3, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Putative DNA repair helicase RAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000381">
        <property type="entry name" value="TFIIH basal transcription factor complex helicase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
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        <property type="entry name" value="DinG/Rad3-like"/>
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    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
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    <dbReference type="InterPro" id="IPR010643">
        <property type="entry name" value="HBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
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        <property type="entry name" value="Helicase-like_DEXD_c2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010614">
        <property type="entry name" value="RAD3-like_helicase_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013020">
        <property type="entry name" value="Rad3/Chl1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001945">
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    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00604">
        <property type="entry name" value="rad3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472:SF1">
        <property type="entry name" value="GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06733">
        <property type="entry name" value="DEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00852">
        <property type="entry name" value="XRODRMPGMNTD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00488">
        <property type="entry name" value="DEXDc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0347">Helicase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="16" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="25">
        <location>
            <begin position="7"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00044969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00078828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00079246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00081072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00081188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00082576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="JAV82700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="KAB0791947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="759" mass="86706" checksum="641C164F48EF25EF" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1MDN8</accession>
    <name>A0A1Y1MDN8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">protein O-GlcNAcase</fullName>
            <ecNumber evidence="6">3.2.1.169</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Beta-N-acetylhexosaminidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Beta-hexosaminidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PPYR_11980</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>3-O-(N-acetyl-beta-D-glucosaminyl)-L-seryl-[protein] + H2O = N-acetyl-D-glucosamine + L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:48876"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:12251"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:90838"/>
            <dbReference type="ChEBI" id="CHEBI:506227"/>
            <dbReference type="EC" id="3.2.1.169"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonyl-[protein] + H2O = L-threonyl-[protein] + N-acetyl-D-glucosamine</text>
            <dbReference type="Rhea" id="RHEA:48892"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:12252"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:90840"/>
            <dbReference type="ChEBI" id="CHEBI:506227"/>
            <dbReference type="EC" id="3.2.1.169"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.2.1.169" evidence="6"/>
    <dbReference type="EMBL" id="GEZM01034451">
        <property type="protein sequence ID" value="JAV83783.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0795141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1MDN8"/>
    <dbReference type="FunCoup" id="A0A1Y1MDN8">
        <property type="interactions" value="2277"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1MDN8"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102571">
        <property type="term" value="F:[protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine/L-threonine O-N-acetyl-alpha-D-glucosaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016231">
        <property type="term" value="F:beta-N-acetylglucosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009100">
        <property type="term" value="P:glycoprotein metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.240:FF:000002">
        <property type="entry name" value="Bifunctional protein NCOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000009">
        <property type="entry name" value="O-GlcNAcase BT_4395"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.240">
        <property type="entry name" value="STAT, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051822">
        <property type="entry name" value="Glycosyl_Hydrolase_84"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011496">
        <property type="entry name" value="O-GlcNAcase_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13170">
        <property type="entry name" value="O-GLCNACASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13170:SF16">
        <property type="entry name" value="PROTEIN O-GLCNACASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07555">
        <property type="entry name" value="NAGidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52009">
        <property type="entry name" value="GH84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH84" evidence="9">
        <location>
            <begin position="57"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="527"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="527"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="553"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00050933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00052136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00066938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00076634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="JAV83783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0795141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1017" mass="113462" checksum="F2618DDE0D232283" modified="2017-08-30" version="1"> </sequence>
</entry>
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            <taxon>Metazoa</taxon>
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            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
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    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
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                <person name="Al-Wathiqui N."/>
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                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
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            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
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        <property type="protein sequence ID" value="JAV83922.1"/>
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    </dbReference>
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        <location>
            <begin position="57"/>
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        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00177"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="JAV83932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0796502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="227" mass="26492" checksum="9EC3438F9E0CDA5D" modified="2017-08-30" version="1">MFTRPLLLSSKLELTRCFKFPQNGMSQYPSYYIKPIYSNDKQTDLIKSGEAQKLAHVPTRAALNDQTSSIYHDDLICLLVNYLMKDGNKLLARDLVEKTMEKIKRVQLEKYHKLANEEEKEKVVLNPRAIIHQAITNVKPILQLTPIKRGGVTYQVPVPITDRRSQFLSMKWLIEAGNEKERTVRFYDQFAYELIDAANNTGRAVKKKQDLHKQCEMNRAYAHYRWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1MMU4</accession>
    <name>A0A1Y1MMU4_PHOPY</name>
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            <fullName evidence="10">Uncharacterized protein</fullName>
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    </protein>
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    </gene>
    <organism evidence="10">
        <name type="scientific">Photinus pyralis</name>
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            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
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            <taxon>Elateroidea</taxon>
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    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
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            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAB0792912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="2">F-box domain-containing protein</fullName>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
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            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
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                <person name="Debat H.J."/>
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                <person name="Day J.C."/>
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    <reference evidence="6" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL24 family.</text>
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    <dbReference type="EMBL" id="GEZM01013992">
        <property type="protein sequence ID" value="JAV92233.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
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        <property type="protein sequence ID" value="KAB0802970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="60S ribosomal protein L26"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
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    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_uL24_CS"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_uL24_euk/arc"/>
    </dbReference>
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        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="KOW" evidence="4">
        <location>
            <begin position="48"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="JAV92233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0802970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="149" mass="17137" checksum="DB824CB960FD64B8" modified="2017-08-30" version="1">MKLNKLVTASRRKNRKRHFSAPSHIRRRLMSSPLSKELRQKYNVRSIPIRKDDEVQVVRGHYKGQQVGKVVQVYRKKFVIYIERIQREKANGASVYVGIHPSKVVIVKLKMDKDRKNIIDRRAKGRLAALGKDKGKYTEESAAAAVDAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1N8S3</accession>
    <name>A0A1Y1N8S3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Signal recognition particle subunit SRP72</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PPYR_05863</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">1611_PpyrPB1</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">1611_PpyrPB1</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the SRP72 family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01009749">
        <property type="protein sequence ID" value="JAV94341.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01009748">
        <property type="protein sequence ID" value="JAV94342.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KAB0801509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="FunCoup" id="A0A1Y1N8S3">
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    </dbReference>
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    <dbReference type="OrthoDB" id="5421607at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000062">
        <property type="entry name" value="Signal recognition particle subunit SRP72"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="Signal_recog_part_SRP72_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026270">
        <property type="entry name" value="SRP72"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031545">
        <property type="entry name" value="SRP72_TPR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14094">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14094:SF9">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE SUBUNIT SRP72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08492">
        <property type="entry name" value="SRP72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17004">
        <property type="entry name" value="SRP_TPR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038922">
        <property type="entry name" value="SRP72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="10 11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="9 11" id="KW-0733">Signal recognition particle</keyword>
    <keyword evidence="7 12" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="12">
        <location>
            <begin position="223"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="Signal recognition particle SRP72 subunit RNA-binding" evidence="14">
        <location>
            <begin position="532"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="528"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="547"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="568"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
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            <end position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR038922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="JAV94342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAB0801509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="648" mass="74033" checksum="27A6E341BF0CAD18" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1NIB8</accession>
    <name>A0A1Y1NIB8_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_00992</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01002383">
        <property type="protein sequence ID" value="JAV97288.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1NIB8"/>
    <dbReference type="InParanoid" id="A0A1Y1NIB8"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="421"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="433"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="489"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="512"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="JAV97288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0804022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="658" mass="75803" checksum="026700B6E1C4701B" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1NID0</accession>
    <name>A0A1Y1NID0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">40S ribosomal protein S4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PPYR_15297</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the eukaryotic ribosomal protein eS4 family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01003689">
        <property type="protein sequence ID" value="JAV96630.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000761">
        <property type="protein sequence ID" value="KAB0790787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1NID0"/>
    <dbReference type="FunCoup" id="A0A1Y1NID0">
        <property type="interactions" value="1040"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1NID0"/>
    <dbReference type="OrthoDB" id="1109245at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06087">
        <property type="entry name" value="KOW_RPS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000005">
        <property type="entry name" value="40S ribosomal protein S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.740:FF:000001">
        <property type="entry name" value="40S ribosomal protein S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.10:FF:000051">
        <property type="entry name" value="40S ribosomal protein S4, X isoform"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00485">
        <property type="entry name" value="Ribosomal_eS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000876">
        <property type="entry name" value="Ribosomal_eS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032277">
        <property type="entry name" value="Ribosomal_eS4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013845">
        <property type="entry name" value="Ribosomal_eS4_central_region"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038237">
        <property type="entry name" value="Ribosomal_eS4_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041982">
        <property type="entry name" value="Ribosomal_eS4_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013843">
        <property type="entry name" value="Ribosomal_eS4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018199">
        <property type="entry name" value="Ribosomal_eS4_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11581">
        <property type="entry name" value="30S/40S RIBOSOMAL PROTEIN S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11581:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN ES4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16121">
        <property type="entry name" value="40S_S4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00900">
        <property type="entry name" value="Ribosomal_S4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08071">
        <property type="entry name" value="RS4NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002116">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00528">
        <property type="entry name" value="RIBOSOMAL_S4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="RNA-binding S4" evidence="8">
        <location>
            <begin position="42"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="9">
        <location>
            <begin position="174"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="JAV96630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0790787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="261" mass="29480" checksum="11F4206EEAD0EEB9" modified="2017-08-30" version="1">MARGPKKHLKRLNAPKAWMLDKLGGVFAPRPSTGPHKLRECLPLVIFLRNRLKYALTNCEVTKIVMQRLIKVDGKVRTDTNYPAGFMDVITIEKTGENFRLIYDVKGRFAIHRITPEEAKYKLCKVKRVQKGPRGIPFIVTHDGRTIRYPDPAIKVHDTIQLEIATCKILDNIKFETGNVCMITGGRNLGRVGTVVNRERHPGSFDIVHVKDANEHTFATRLHNVFIIGKGTKPYVSLPKGKGIKLSIAEERDKRLAAKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N3ZZ50</accession>
    <name>A0A5N3ZZ50_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_15316</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01001449">
        <property type="protein sequence ID" value="KAB0790343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N3ZZ50"/>
    <dbReference type="InParanoid" id="A0A5N3ZZ50"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF1">
        <property type="entry name" value="GAG-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0790343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="130" mass="15121" checksum="B76BBC6B9E835FA5" modified="2020-02-26" version="1" fragment="single">MPWIEPNVRVDSNFNGAFNRLKSLTRKLNERGKLREYDCAMREYMNNDCAELLPEVTNDIRIYFMPHRAVYRDDKDTSKLRIVFDASAHAPGMPSLNDVLLQGENLVPFLLRILMNFRVGRVAFTADIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N3ZZ62</accession>
    <name>A0A5N3ZZ62_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">FLYWCH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PPYR_15285</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01001438">
        <property type="protein sequence ID" value="KAB0790346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N3ZZ62"/>
    <dbReference type="InParanoid" id="A0A5N3ZZ62"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018289">
        <property type="entry name" value="MULE_transposase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007588">
        <property type="entry name" value="Znf_FLYWCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47160:SF10">
        <property type="entry name" value="MULE TRANSPOSASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47160">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04500">
        <property type="entry name" value="FLYWCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10551">
        <property type="entry name" value="MULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FLYWCH-type" evidence="4">
        <location>
            <begin position="5"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="MULE transposase" evidence="5">
        <location>
            <begin position="185"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0790346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="432" mass="49695" checksum="C00D2B57AD6346C3" modified="2020-02-26" version="1" fragment="single">MALEFVSSEKGKSKLFFESFLFIKDKQVDTKIYWKCEHSKKMKCKARVITVNNFVSSSNNDHNHNADAAQLEANKVMQKIKEDAENTRDTPQFIVSQASAGLGNAVAAKLPTVNNIKRTIRNVRVRENVAPAIPRHREEIIFPEEFTITTNGELFLLHDSGPVNDRILIFSTARNINLLAMSQHWYADGTFKVVPPLFLQLYTIHGIKDHVAIPLIYALLPNKTEQTYLNLLREIKNLLPADDAQPQTIMTDFEVAMINAIRIEFPQTIHRGCFFHLCQSIFRHIQENGLKREYERNPEVALTLKLLPALAFVPPQDVIPAFEDICEQNIFSPELQVIVDYFEDTWIGRPQRRGRRPPHFAINMWNCFDAVQHGLPKTNNAVEGWHRAFQMQLCADHPNIWKFISALKREQSINELRIEQHISGQPPTISRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-06-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N3ZZC8</accession>
    <name>A0A5N3ZZC8_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_15213</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01001349">
        <property type="protein sequence ID" value="KAB0790416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N3ZZC8"/>
    <dbReference type="InParanoid" id="A0A5N3ZZC8"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0790416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="69" mass="7679" checksum="928363CB67387E97" modified="2020-02-26" version="1" fragment="single">ILWREKPSDPLTEFQLNTVTYGISSASYWAIRSLFQIALENVNAYPAASKGSNSLTDLTNICKEIIINS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N3ZZM7</accession>
    <name>A0A5N3ZZM7_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_15127</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01001226">
        <property type="protein sequence ID" value="KAB0790478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N3ZZM7"/>
    <dbReference type="InParanoid" id="A0A5N3ZZM7"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052997">
        <property type="entry name" value="RRT15-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33047">
        <property type="entry name" value="PROTEIN TAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33047:SF8">
        <property type="entry name" value="REGULATOR OF RDNA TRANSCRIPTION PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0790478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="62" mass="6700" checksum="AC87111CE51E109E" modified="2020-02-26" version="1" fragment="single">PAFAVPMLTEHRDQASICPFALREVSVLAELALGHLRYSLTDVPPQSNSPPGGVLESDRDRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A1L9</accession>
    <name>A0A5N4A1L9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Small ribosomal subunit protein eS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PPYR_02989</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="5">Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the eukaryotic ribosomal protein eS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A1L9"/>
    <dbReference type="FunCoup" id="A0A5N4A1L9">
        <property type="interactions" value="840"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A1L9"/>
    <dbReference type="OrthoDB" id="9834376at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03122">
        <property type="entry name" value="Ribosomal_eS1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001593">
        <property type="entry name" value="Ribosomal_eS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018281">
        <property type="entry name" value="Ribosomal_eS1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027500">
        <property type="entry name" value="Ribosomal_eS1_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11830">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01015">
        <property type="entry name" value="Ribosomal_S3Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01397">
        <property type="entry name" value="Ribosomal_S3Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01191">
        <property type="entry name" value="RIBOSOMAL_S3AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="initiator methionine" description="Removed" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="236"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0791189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="267" mass="30117" checksum="A49E3F013131E473" modified="2020-02-26" version="1">MAVGKNKGLSKGGKKGVKKKIVDPFTRKDWYDVKAPTMFATRQIGKTLVNRTQGTKIASEGLKNRVFEVSLADLQNDNDAERSFRKFKLVAEDVQGNTVLTNFHGMDLTTDKLRSMVKKWQTLIEASADVKTTDNYLLRVFCIGFTNKDQLSQKKTCYAQHTQVRQIRKKMIEIITRDITGSELKEVVNKLLPDSIAKDIEKACQGIYPLHDVYIRKVKVLKKPRFELSKLLELHGEGGKTSSSEPAEVGSKVDRPEGYEPPVQESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A1Q3</accession>
    <name>A0A5N4A1Q3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Peptidase M14 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PPYR_03060</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the peptidase M14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A5N4A1Q3">
        <property type="interactions" value="770"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A1Q3"/>
    <dbReference type="OrthoDB" id="10249045at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006518">
        <property type="term" value="P:peptide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03858">
        <property type="entry name" value="M14_CP_N-E_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03868">
        <property type="entry name" value="M14_CPD_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11308">
        <property type="entry name" value="Peptidase_M14NE-CP-C_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000020">
        <property type="entry name" value="Carboxypeptidase D"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1120">
        <property type="entry name" value="Carboxypeptidase-like, regulatory domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057246">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057247">
        <property type="entry name" value="CARBOXYPEPT_ZN_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050753">
        <property type="entry name" value="Peptidase_M14_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11532:SF62">
        <property type="entry name" value="CARBOXYPEPTIDASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11532">
        <property type="entry name" value="PROTEASE M14 CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13620">
        <property type="entry name" value="CarboxypepD_reg"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="Carboxypeptidase regulatory domain-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00132">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00133">
        <property type="entry name" value="CARBOXYPEPT_ZN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024393587" description="Peptidase M14 domain-containing protein" evidence="11">
        <location>
            <begin position="20"/>
            <end position="1385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1287"/>
            <end position="1311"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M14" evidence="12">
        <location>
            <begin position="34"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M14" evidence="12">
        <location>
            <begin position="442"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M14" evidence="12">
        <location>
            <begin position="835"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="301"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="704"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAB0791260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1385" mass="156593" checksum="963A04F1BBA7F297" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A2A5</accession>
    <name>A0A5N4A2A5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RIIa domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_03231</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
            <location evidence="1">Flagellum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ropporin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A2A5"/>
    <dbReference type="InParanoid" id="A0A5N4A2A5"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd23019">
        <property type="entry name" value="DD_ROP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.890.10">
        <property type="entry name" value="cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047844">
        <property type="entry name" value="ROP_DD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14952:SF9">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14952">
        <property type="entry name" value="ROPPORIN-1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47391">
        <property type="entry name" value="Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0969">Cilium</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0282">Flagellum</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="282"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0791431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="445" mass="49799" checksum="4FCC9BF815E2C9FE" modified="2020-02-26" version="1">MPDFNDDMYCSQQICIPPTFPYLLRQYAKAAIRTQPADLLRWSTAYFRCLALNVPPPVKPRLEYPIPKSHFGLTPGWLRALMYQLQNNLTVSFKVLWDRWIGACLQHENLIEILVLGGFADPNAIPWFRFVALCAGHLTENLTQTMVMVCEILTEEPEGGSATVPLEVFADLYGFLAAIDASEPQRLANLYFTDSLLSLYREPPPAVASESTIEIEEEVVEEEAVSEEEKVEEAEAGPVEDLVGVVISCPDIAIDDNKTEDDFMAETVGRPSADYQSPVVPAEVIALENADLEEERQQQADESVDTLIGYMPERQGIAEYLEEVQKCEVEEEGGEEEVDEDLQKLKALLEMAPGAPEAAVDETVLSDASMEERQDMVSEEGVDEVEQRLNYILVDAIPGIGPIVPHELVEDVKKYMKECSVAQHGMVMPRNLRHFRCPPLEVVHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A5D9</accession>
    <name>A0A5N4A5D9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">GTP-binding protein Rhes</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PPYR_14480</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the small GTPase superfamily. RasD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A5D9"/>
    <dbReference type="FunCoup" id="A0A5N4A5D9">
        <property type="interactions" value="82"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A5D9"/>
    <dbReference type="OrthoDB" id="265044at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000475">
        <property type="entry name" value="GTP-binding protein Rhes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052236">
        <property type="entry name" value="Small_GTPase_RasD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46149:SF7">
        <property type="entry name" value="GTP-BINDING PROTEIN DI-RAS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46149">
        <property type="entry name" value="MIP08469P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0636">Prenylation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="234"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0792521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="276" mass="30961" checksum="7B71545B2D90C87C" modified="2020-02-26" version="1">MKGRHQFRRRFSLQPSFHKEEPENDRHHHTRSQRSEDASDLEEKHDTIGSLTIVRHKIVVLGAAKVGKSSLISQFLYGTFSPKYKRTVEEMHQGDFDVSGVQLTLDILDTSGAYEFPAMRALSISSADAFILVYDVNDAPTFEEVRSLRDLIHETKCSSAVPIVVVGNKTDLVGNREMDTAMTESVVTVDWENGFVECSAKDNVNVSKVFKELLAQAKVKYNLSPALRRRRRQSLPSQAGVPPSSSPHPAIPSAVQLQHLQQIRDRHGKRNSCILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A631</accession>
    <name>A0A5N4A631_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">UDP-glucuronosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PPYR_14753</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A631"/>
    <dbReference type="InParanoid" id="A0A5N4A631"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF159">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024336338" description="UDP-glucuronosyltransferase" evidence="5">
        <location>
            <begin position="17"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="404"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0792794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="438" mass="49827" checksum="742E4793A320A2CB" modified="2020-02-26" version="1">MKEIWFVFSLVVSCSSERILAVTPSHENQAAFQPLWKELVSKGHHITLLTTDSQANWSLKKVNEINLGSALSTTFEKLDHPKVRALIADQTERFDLLMVDYTMPELLLFSQRFNCPSIGLLAKEVPIPALYDIGNPTYPYPRRFRDRIANVVNNYLSEWLVAFRHRELQKLFGSNHPPSRDPSALLVFSNQMLLQNRPLVPNVIQVGQLTNDNAIPKDVLPFLDEATEGFIYINLAVPPHGLLEALADIPYKLVWDSILDNQQKKPPNMLTRKHLPRRAILEHPKIKLLVTSGDLQTLDDAVSGHVPVICMPLDSSDEESCRTVVVDKGFGISIDPETLHGEDLKRRIDEVVLNPLYRDNLQRFAKLLRNSPLGGLDLAVWWTEYVLRHNGAPHLRSPLCDLPWWQYLFIDVLLAYLLITLCLLVIIGKVIGHFVKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A650</accession>
    <name>A0A5N4A650_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_14775</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A650"/>
    <dbReference type="InParanoid" id="A0A5N4A650"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF9">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="251"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="271"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0792816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="505" mass="57545" checksum="A5DB304AECE91EE9" modified="2020-02-26" version="1">MVLSATLILFPAKLFMSRKKNKKNIDESFGELQDNSSVGRRHITFQPPAQFDFQCPEKWEKWFKRFERYRMASGLDQEPEEKQVTSLIYCMGENAEDILTRSQLPEEKLNSYKTVKAAFDEAFIGKRNILYERAKFNSRNQKKGEIFEQFLTDISLMAERCAFRDLRDELVRDRIVVGILDKTLSSQLQEDADLTLEKAIQKAKQRESIKKQTYELEEIQSKPSSEVDRIHSSSSSKFPLKESTTDIMEGGCWNCGGPRHPRNSCPAKDYTCKCGKVGHFKKMCKSNTIVGKFTKKIGELRESSQISVSEQEDDATYLGALNTIGGVSNAWYVDIFINNQKVKAKLDSRAEVTAIPSNILKQIPNLFKSDKTLKNADQNIMVVDGMFTADLEFNGQKVKEKIYVIPTLSEPLLGITAIKSLNLITVRKSYESGNIQSIALDKVVQEYPQLFMGLGNIPGEYKIELIDDAKPYSFVPNLAGKTEAFRERKIESFVGPKIIRKFFQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A6B6</accession>
    <name>A0A5N4A6B6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Short-chain dehydrogenase/reductase 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Retinal short-chain dehydrogenase/reductase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PPYR_14826</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the reduction of all-trans-retinal to all-trans-retinol in the presence of NADPH.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A6B6"/>
    <dbReference type="FunCoup" id="A0A5N4A6B6">
        <property type="interactions" value="119"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A6B6"/>
    <dbReference type="OrthoDB" id="10253736at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052650">
        <property type="term" value="F:all-trans-retinol dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05339">
        <property type="entry name" value="17beta-HSDXI-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000131">
        <property type="entry name" value="Short-chain dehydrogenase/reductase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322:SF729">
        <property type="entry name" value="MIP05442P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322">
        <property type="entry name" value="PKSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="17"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00059620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00068717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00082544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAB0792867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="317" mass="35688" checksum="C217BD9D1252889F" modified="2020-02-26" version="1">MWFKELVLRVVGGTWEFLVICALCVYYCMETVLLTITPSFLRWQKSLKGKRIVITGGAGGVGQELALQLGRLQAKVVVWDTNERAVEALRLRFYNEGMELQSYIVDVTDRHSVYKHANLVKSDLGPVDILINNAGIVTGRTFLDIPDDMVEKTFQVNVISHYWTIKAFLSDMLKRGKGHVVSVGSLTGMLGTYKCTDYSATKYALHGLHESLLTELKTHGYDNIHLTLVSPFFINTGMFAGCKPRTLSMLEPKNVATRIITAIRREETFLTMPASYRFIIPIKFYVPSKLCWAVMYRVIQGPQSMMGLVGRQDTTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A6P1</accession>
    <name>A0A5N4A6P1_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_12605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0792985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A6P1"/>
    <dbReference type="InParanoid" id="A0A5N4A6P1"/>
    <dbReference type="OrthoDB" id="6782215at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0792985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="151" mass="16884" checksum="F4DCB9164311B0D1" modified="2020-02-26" version="1">MSKKKVSRLTPTGNFDGKMSKDLGSLCKEPKFFLKIIVLVLCILETSILFHYGLSWCIRRSPLYMSIFCAHAYICIMGVYILAYVFDSGHEFTEKLFLIIGAIMSVVTGIVIFLETSDRFSTCSNDPVTALGVITTASGVVMVIDYLMQRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A704</accession>
    <name>A0A5N4A704_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_12730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A704"/>
    <dbReference type="InParanoid" id="A0A5N4A704"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0793110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="201" mass="22501" checksum="6BB6138640BA8032" modified="2020-02-26" version="1">MTRKSSLFAVTSNMPKKNTTQTKAPSKTQTRWADNDDMENDLYSISCFGQQVKDPPAPSIHVRKPVVKSVYDLDDFDSEQMPVKAFGRGRMMQNIKGSDFLKRTSEISQEIRLTQSGYGYCNDQIEHALNCDTIQSSVRSSPQLSETASRSSTPNNVATSRPLMPLCDIVRSGVRARKVDVHTPTEKNPINLSSLKEFPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A7S8</accession>
    <name>A0A5N4A7S8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Dynein regulatory complex protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_12969</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DRC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A7S8"/>
    <dbReference type="FunCoup" id="A0A5N4A7S8">
        <property type="interactions" value="28"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A7S8"/>
    <dbReference type="OrthoDB" id="10260459at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005858">
        <property type="term" value="C:axonemal dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070286">
        <property type="term" value="P:axonemal dynein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060285">
        <property type="term" value="P:cilium-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003352">
        <property type="term" value="P:regulation of cilium movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039505">
        <property type="entry name" value="DRC1/2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039750">
        <property type="entry name" value="DRC1/DRC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029440">
        <property type="entry name" value="DRC1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21625:SF1">
        <property type="entry name" value="DYNEIN REGULATORY COMPLEX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21625">
        <property type="entry name" value="NYD-SP28 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14772">
        <property type="entry name" value="NYD-SP28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14775">
        <property type="entry name" value="NYD-SP28_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynein regulatory complex protein 1/2 N-terminal" evidence="5">
        <location>
            <begin position="91"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein regulatory complex protein 1 C-terminal" evidence="6">
        <location>
            <begin position="702"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="111"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="325"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="728"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0793349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="784" mass="91662" checksum="163B9E9163A51C9D" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A829</accession>
    <name>A0A5N4A829_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_13093</name>
        <name evidence="4" type="ORF">PPYR_13094</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A829"/>
    <dbReference type="InParanoid" id="A0A5N4A829"/>
    <dbReference type="OrthoDB" id="6819313at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="16"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="63"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="98"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="365"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0793473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0793474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="475" mass="53596" checksum="F95782A633FE7D56" modified="2020-02-26" version="1">MPFLLRFLGLSKSHEVALLVSIVICHAMYDMYNLEFTVNLNRIWDARFRFGSFPEEIETCIKYILWTLVVLRSFTTPFYLALSCVIFWAALLSDRPLFLVPWLVTGFFKNVVPSILSLIVAVYTCIVTDLQIWACCIFILTQMSSSAFFVYLWSSVQSLYKDQQIDTSTDQMAKEKEVVVRRRKARLMKGYPEVFYESCIEEEIHLKCVSTFENLMQRVREKKGPKQAKSIDSLLQSIASTVEENEWNNMFERSHRLVSNKTIKQTVMQTFGLTDEDIYIAKIHQNEEFKRILSETGIPKVSSDDDTFLSALSNPSSSAQDTVSNDENACGSASTLESTFSNDSETQICAVVNYSTTSLADKSVETNPISDDSKLETRSPIPLPTPNLRTTPAFYFEVSNGASKPSVNNKVVLSDFGCQVSTLSRNILNSPPKEFLTFFPESTSLSYGICESRSSLLNRGTSAHALKSPTAQYCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A8F4</accession>
    <name>A0A5N4A8F4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF19 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_13212</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A8F4"/>
    <dbReference type="InParanoid" id="A0A5N4A8F4"/>
    <dbReference type="OrthoDB" id="8194670at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007608">
        <property type="term" value="P:sensory perception of smell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23992">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.20">
        <property type="entry name" value="Pheromone/general odorant binding protein domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006170">
        <property type="entry name" value="PBP/GOBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036728">
        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11857">
        <property type="entry name" value="ODORANT BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01395">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024432667" description="DUF19 domain-containing protein" evidence="2">
        <location>
            <begin position="16"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0793592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="229" mass="25472" checksum="247FBAFC5C6F1535" modified="2020-02-26" version="1">MKILVIFACFSVVYAQKEHGKIMKECMEESGVNKDLLHYTFKTRNVTKDDNLIAFFTCTMVKYGSLNNQTCQVNLTGIKDMCTKMQLGDCSFVDTCEKKQGADCKETVFLVNQCVLPHLPGNGSENVIEACKNQSKVGADLIMKLHKEGIVSDDPSMVKFLGCVTDRFGCFDESGSISLKYLRGICAWKKCADCSFIDECEKKKGGSKDETAFLALSCAYPQMCKAKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ABT4</accession>
    <name>A0A5N4ABT4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Fringe-like glycosyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PPYR_11547</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Endomembrane system</location>
            <topology evidence="9">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0794708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ABT4"/>
    <dbReference type="FunCoup" id="A0A5N4ABT4">
        <property type="interactions" value="23"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4ABT4"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.50:FF:000008">
        <property type="entry name" value="Beta-1,3-glucosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003378">
        <property type="entry name" value="Fringe-like_glycosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10811">
        <property type="entry name" value="FRINGE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02434">
        <property type="entry name" value="Fringe"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fringe-like glycosyltransferase" evidence="11">
        <location>
            <begin position="127"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Fringe-like glycosyltransferase" evidence="11">
        <location>
            <begin position="268"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAB0794708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="495" mass="56580" checksum="9F59DC91C5DD3463" modified="2020-02-26" version="1">MDAMSSSRFSGSRLPEGPKTKKEVQTKVESEVEIVDLTVEQMKSHGLQSDTLCITNINEIVIIISSQSNRHHEALAEDLKSDIIQQSHILNKDAPIVHLTHIDFPDVVGAWTILPLIPYLRKLHHGNCSWFFFMEDKTRIRLGELLELLNGYDYTQEMWLGHAIRDREATIIHHFQFFEDPQRFAYPNAASGFAISAGLMKRLEVQWGRRKTSSADFSIDYAYELALFIWNDKKGTELTHAPRLCRSAKGNCATYSTSFQHCETSVPKTSIYFAVKTCGKFHGDRVTVVKGTWGKYAEIIRYFSDVEDEAIPTISLGIPNTEQGHCGKTIAILQYVANEIENRPEIKWIIIADDDTILSVARIQKFLSCYNDSEQIVLGERYGFNVYNEDGYNYITGGGGIIFSRGSMQNVVNSNMCKCPSISSPDDMFLGVCFRRLKIEVIHSSLFHQARPVDYAPEYLKDENVVSFHKHWMIDPFAVYNQWFQQEDTQMHNEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ABZ1</accession>
    <name>A0A5N4ABZ1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">S1 motif domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_00282</name>
        <name evidence="3" type="ORF">PPYR_11607</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0794768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ABZ1"/>
    <dbReference type="FunCoup" id="A0A5N4ABZ1">
        <property type="interactions" value="325"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4ABZ1"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.310:FF:000001">
        <property type="entry name" value="RNA-binding transcriptional accessory protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.140:FF:000001">
        <property type="entry name" value="RNA-binding transcriptional accessory protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.650:FF:000001">
        <property type="entry name" value="S1 RNA-binding domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.650">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3500.10">
        <property type="entry name" value="Tex N-terminal region-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.310">
        <property type="entry name" value="Tex RuvX-like domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.140">
        <property type="entry name" value="YqgF/RNase H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041692">
        <property type="entry name" value="HHH_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050437">
        <property type="entry name" value="Ribos_protein_bS1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055179">
        <property type="entry name" value="Tex-like_central_region"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023323">
        <property type="entry name" value="Tex-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023319">
        <property type="entry name" value="Tex-like_HTH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018974">
        <property type="entry name" value="Tex-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032639">
        <property type="entry name" value="Tex_YqgF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006641">
        <property type="entry name" value="YqgF/RNaseH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037027">
        <property type="entry name" value="YqgF/RNaseH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10724">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10724:SF10">
        <property type="entry name" value="S1 RNA-BINDING DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12836">
        <property type="entry name" value="HHH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17674">
        <property type="entry name" value="HHH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22706">
        <property type="entry name" value="Tex_central_region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09371">
        <property type="entry name" value="Tex_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16921">
        <property type="entry name" value="Tex_YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00732">
        <property type="entry name" value="YqgFc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158832">
        <property type="entry name" value="Tex N-terminal region-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1 motif" evidence="2">
        <location>
            <begin position="743"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0794768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0803312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="808" mass="91308" checksum="1771064241A6B419" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ADJ3</accession>
    <name>A0A5N4ADJ3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PPYR_12147</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0795308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ADJ3"/>
    <dbReference type="FunCoup" id="A0A5N4ADJ3">
        <property type="interactions" value="169"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4ADJ3"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000095">
        <property type="entry name" value="B(0,+)-type amino acid transporter 1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF531">
        <property type="entry name" value="LARGE NEUTRAL AMINO ACIDS TRANSPORTER SMALL SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="155"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="231"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0795308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="346" mass="38246" checksum="EF0C762481FFF2BC" modified="2020-02-26" version="1">MTSTSKKDFAFEQLFVLSGVLTFVNCYDVKWATRVQDVFTYAKLLALFVIIAAGGYQLCNGHTEHFTFINTKTEVTSLALSFYSGLFAYNGWNYLNFIIEELKDPVRNLPLAIAISCTLVTIVYVLTNVAFYTTLSPAEVLGSEAVAVSFANKLFGPFALSIPIFVALSTFGAVNGILLTSSRLFYAGACHGQMPEILTMIQAKRLTPTPAVLAMALLSMLYLTVSDIFALINYVGFATWLSIGVSVLCLPWLRWKAPNLERPIKVNLIWPIIYLLATIFVTAVPMIASPVETGIGLLMILTSVPVYVALIMWKNKPWWYQKIISKITVALQMIFVVVGKSKAAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AEL1</accession>
    <name>A0A5N4AEL1_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_09800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0795739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AEL1"/>
    <dbReference type="InParanoid" id="A0A5N4AEL1"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23992">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.20">
        <property type="entry name" value="Pheromone/general odorant binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006170">
        <property type="entry name" value="PBP/GOBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036728">
        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01395">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0795739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="123" mass="13814" checksum="B8FCA713D6631EEC" modified="2020-02-26" version="1" fragment="single">QVPEEFRMDWVSTAEPFRADCECESGIAPDLSQRVLSLADFPNDSCLKSYMFCIDTKLNLINPATPTYELRVNEYVHRVTGVDHTIASKCVNATSGLKDPREKVYQMSLCIVFSLVQPPISIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AER2</accession>
    <name>A0A5N4AER2_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FLYWCH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PPYR_09881</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0795820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AER2"/>
    <dbReference type="InParanoid" id="A0A5N4AER2"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007588">
        <property type="entry name" value="Znf_FLYWCH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04500">
        <property type="entry name" value="FLYWCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="281"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="FLYWCH-type" evidence="5">
        <location>
            <begin position="4"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0795820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="312" mass="35349" checksum="62FDDE43C1E15A11" modified="2020-02-26" version="1">MATFFTSERKKQKMVWEGFVYNLNKDPGKGRRYWICEEYFTSVKCVGRAITDGDNVVTVTKTHYGHAPSAVAVQAKQVRSKIQEVAGDPGNRNAPRTVVNECLAGTSDAAIAIHPKLTSLEQAVRRKRKFGGANEDIPNSLADVYFPDELRHTKTELEEDIVFADTGANDPQRIIILGSPTNLRRLLRCTTWLCDGTFHTSPNAFYQIDSVHGLYQRRVIPFLTCLLPNKTRATHEKLIQLILDRIDRIIEVDNIQYRPQTIIIDRLSRRVSNKLFAPRSLWLIFMVAGSIFVKLIGELFSAATCKQGMHRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AES7</accession>
    <name>A0A5N4AES7_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_09799</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0795738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AES7"/>
    <dbReference type="InParanoid" id="A0A5N4AES7"/>
    <dbReference type="OrthoDB" id="6758797at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23992">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.20">
        <property type="entry name" value="Pheromone/general odorant binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006170">
        <property type="entry name" value="PBP/GOBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036728">
        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01395">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024387683" evidence="1">
        <location>
            <begin position="20"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0795738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="142" mass="15614" checksum="1278BF889A8C9E3D" modified="2020-02-26" version="1">MYTTLHVLSCLLIPTLTAAISVVPEEIRMDWVSTAEPFRTDCECESGIAPDLSQRVLSLAEFPNDSCLKCYMCCLSTNLNLMNPATYELSVKELVRRVAGVDYVIATKCVNATSGLKNPSEKVYQTSLCIVFSLVQPPISIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AFG3</accession>
    <name>A0A5N4AFG3_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_10112</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AFG3"/>
    <dbReference type="InParanoid" id="A0A5N4AFG3"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032222">
        <property type="term" value="P:regulation of synaptic transmission, cholinergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030431">
        <property type="term" value="P:sleep"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031424">
        <property type="entry name" value="QVR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045860">
        <property type="entry name" value="Snake_toxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17064">
        <property type="entry name" value="QVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57302">
        <property type="entry name" value="Snake toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024443088" evidence="3">
        <location>
            <begin position="20"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0796051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="107" mass="11870" checksum="1DE0895B2538C418" modified="2020-02-26" version="1">MKIVVTLWVFIVAITGGSALKCYLCAGSLKSDCKVGKQISMVEQECLNFPNFHDFCIQGTSTKTVRPEVFMRGCAIIPKNETDPCKYLANFVPILGCQFCTTDFCNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AFH5</accession>
    <name>A0A5N4AFH5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">15-hydroxyprostaglandin dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_10153</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AFH5"/>
    <dbReference type="InParanoid" id="A0A5N4AFH5"/>
    <dbReference type="OrthoDB" id="37659at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000149">
        <property type="entry name" value="15-hydroxyprostaglandin dehydrogenase [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229:SF8">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0796092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="265" mass="28447" checksum="62D06276C0271CEF" modified="2020-02-26" version="1">MFEITGKVALITGASSGIGAAIASELLQAGAKGVSVVDINEGLGWEVSAELNKKFGNGRAVFIKTDVSNRRQLEDAFTKTVNVFNQLDIVVNNAAARGERNWEKNIAVNLTGIVTGTILAYEHFLPKYKSSEEGAIINIASMAALYSYPSTPVYSAAKMGVIGITRSLGAKQHYQRTKIKVIAVCPGYTSTNILQDIAAEDLLGDDYYKIQVDMMKLAPIAQPTTAVSRAVVEVIGIGASGSVWIADQNQSPYEVKVLCKRKSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AG34</accession>
    <name>A0A5N4AG34_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">15-hydroxyprostaglandin dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_10371</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AG34"/>
    <dbReference type="FunCoup" id="A0A5N4AG34">
        <property type="interactions" value="119"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AG34"/>
    <dbReference type="OrthoDB" id="417891at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000149">
        <property type="entry name" value="15-hydroxyprostaglandin dehydrogenase [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229:SF8">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0796310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="265" mass="29107" checksum="3857051B0D3CB7A3" modified="2020-02-26" version="1">MFELEGKVALITGGASGIGLSIVKELMANGLKAITVVDFNETAGDRVGQEVIEEFGANRAIFVKADVGNVTEFKGAFEATVEKFGNLDIVINSAGIFNEIEWERMIKTNINGTIHGCLLALDYLQRYRRAIEGVIINISSIMGLQTAGHTPFYNTTKHAIVGLGRSLGLHGHYESTAVKVITICPGCTATPLLLENMEERFSKKQIEMHTEVMKKFQLQSANNVARELTAIIKHGQSGSVWLIENDEPAYQVETPHYSDMRVPHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AG80</accession>
    <name>A0A5N4AG80_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">VM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_10392</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AG80"/>
    <dbReference type="InParanoid" id="A0A5N4AG80"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024393393" description="VM domain-containing protein" evidence="2">
        <location>
            <begin position="25"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="103"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="135"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0796331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="144" mass="15824" checksum="29DCA1C156795643" modified="2020-02-26" version="1">MYQVFVSLLVAFALLGVIPQTTSSQIYGYGQVIPNLLDILVPQQMLDYYPQRPNDFGRSGDQFRQGYQSPPPQPPQEKECPVPNTDNTVPSRVPSNDQPINLTPHEPAPTAAPHVPPAPHVTPAPHVTPKPPPKKVCTCPPDQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AGR1</accession>
    <name>A0A5N4AGR1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Peptidase M14 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PPYR_10544</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the peptidase M14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AGR1"/>
    <dbReference type="InParanoid" id="A0A5N4AGR1"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000084">
        <property type="entry name" value="Carboxypeptidase B2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057246">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705:SF140">
        <property type="entry name" value="FI02848P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705">
        <property type="entry name" value="PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00132">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024407534" description="Peptidase M14 domain-containing protein" evidence="11">
        <location>
            <begin position="20"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M14" evidence="12">
        <location>
            <begin position="33"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAB0796483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="274" mass="32079" checksum="F5CEDC0CBBB6F358" modified="2020-02-26" version="1">MNWMKLMVIAFFQIARLRVQETPNKSGEIKFDQYLAYRDIQHYLNVLKTKYNEIVEVKNFGMSVENRHLTYIQIGNKTRRNGPLIFIDAGIHAREWISPAQALYTISQLVENRNNAAMIKDVDWVIVPLVNPDGYEYSRRVDRFWRKNRAKGRICYGVDLNRNFDFHWLGHGGSDSECSNFFAGMRPFSEPESFALSRLIRENSKRIKIYISFHAAAQSILYPWGYTKDLPENGKELHKLATKVSDAVHKFRLDLRCCECKTVLHNRVKRSIRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AH80</accession>
    <name>A0A5N4AH80_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">O-acyltransferase WSD1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_10763</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AH80"/>
    <dbReference type="InParanoid" id="A0A5N4AH80"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009721">
        <property type="entry name" value="O-acyltransferase_WSD1_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06974">
        <property type="entry name" value="WS_DGAT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="O-acyltransferase WSD1 C-terminal" evidence="2">
        <location>
            <begin position="386"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0796702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="528" mass="59687" checksum="43161084EEF5E99D" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AI70</accession>
    <name>A0A5N4AI70_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">LRRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_11072</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0797011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AI70"/>
    <dbReference type="InParanoid" id="A0A5N4AI70"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001164">
        <property type="entry name" value="GH01279p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050328">
        <property type="entry name" value="Dev_Immune_Receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373:SF370">
        <property type="entry name" value="FISH-LIPS, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373">
        <property type="entry name" value="SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0797011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="337" mass="38364" checksum="2D71879EE2785D17" modified="2020-02-26" version="1">MEWLAPLRSLKHLDLSYNRINNFSMSLQSLEFLNMSNNKLEEINAGAFEKLQTLGELDLSYNSLVTLPDDALKGLEHLAILHLAGNKINHLPSKVFMHTPTLEMLLLSGNRLTSIGNIGFDYLGKLRHLQLSSNNLQTLPASPFSKLQALEELDLENTGLSALDPAMFVGLHTLQSLNVSANKLQHLKPGVFHHLVNLQVLNVQDTGLTRLELGTFSDTKNLIHLNLAENRVPQLSEGIFDDISLEILSIRGNPIRTIGRNIYRGQVKLREINFENTSIESLEETDVIPDLRYAMLRGTKFENRTVFRIKTRRFERINERTWDTWCPEYLLTCHDDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AIL4</accession>
    <name>A0A5N4AIL4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Protein krueppel</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PPYR_08189</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the snail C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AIL4"/>
    <dbReference type="InParanoid" id="A0A5N4AIL4"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048598">
        <property type="term" value="P:embryonic morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000557">
        <property type="entry name" value="zinc finger and SCAN domain-containing protein 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000478">
        <property type="entry name" value="Zinc finger protein 133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000072">
        <property type="entry name" value="zinc finger protein 143 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000358">
        <property type="entry name" value="zinc finger protein 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050527">
        <property type="entry name" value="Snail/Krueppel_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012934">
        <property type="entry name" value="Znf_AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388:SF99">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF52.1-LIKE ISOFORM X1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07776">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00868">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51915">
        <property type="entry name" value="ZAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZAD" evidence="10">
        <location>
            <begin position="14"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="129"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="162"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="190"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="220"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="248"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="277"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="308"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="337"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="365"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="393"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0797195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="416" mass="48239" checksum="3D887378EDC1C50F" modified="2020-02-26" version="1">MSEEVKNDHLDFKKICRICLQSSTKMQYLFEFNAKATQLMDELTNIKATENDGLPTNLCDPCATILQQSVDFKRKIQESHKILERCLLNNLVQRQEPRAPKVINSEMQLALTELKNSTPATFITQKNLCKCHICEKHFTCKGQLTRHLKTHTAKHSDRKKPHNCPECNQGFDLRSTLIRHQRIHTGEKPFGCEICRKFYPSKSYLNKHKKIHFATRDKLFICEICSKSFSLKDGLKAHLITHSSERAHKCSLCDRSFAMKASLVSHIKYIHTKEKDFMCQVCAKTFVTRCELNEHIRRHTGEKKEPKHICMMCNKKLSSATHLKFHLRSEHTGERPYCCKFCTKSFITAQALKIHTRYHTGERPYTCNFCSKSFVTNESLKVHERIHTGEKPFTCTICNSSFSQSSTLKTHLKTHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2024-05-29" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AKD6</accession>
    <name>A0A5N4AKD6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_08736</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AKD6"/>
    <dbReference type="InParanoid" id="A0A5N4AKD6"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902936">
        <property type="term" value="F:phosphatidylinositol bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1200">
        <property type="entry name" value="Alpha-tocopherol transfer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.20">
        <property type="entry name" value="N-terminal domain of phosphatidylinositol transfer protein sec14p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174">
        <property type="entry name" value="ALPHA-TOCOPHEROL TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174:SF216">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00180">
        <property type="entry name" value="CRETINALDHBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="50"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0797743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="392" mass="45170" checksum="C23F291305316408" modified="2020-02-26" version="1">MSSLALNLTRFLGDQLLVSFLRCSKFSLERTKERLDRYFTIRTMAPEVFTNRDPLLPELQAILEAGFILPLPNVAKENNHRIIVLRYSNNLDPNLMTMVNIAKLSYMILDILLREDDNAVVSGVVFWSYCKDCPSKYAIQLTPASLQRYSVIEEKGFPFRMKGAYYSHVPQIFEACYNIFKVFCSDKLKQRMGLYSESNIEELFKKIPKDLLPQEFGGCNGSVKDLTVFWKDKVESCRDWFLKDEHCKIDERLRPGTPKTCSEVFGLEGAPTSTRTATDCRERIERSEFSSEFNLTRFLGDQLLVSFLRCSKFSLERTKERLDRYFTIRTMAPEAFTNRDPLLPELQAILNAGFFLPLPKVANENGPRIILLRINDNLNPNLMTVVNLSKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AKV4</accession>
    <name>A0A5N4AKV4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PPYR_08975</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the DEAD box helicase family. DECD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AKV4"/>
    <dbReference type="FunCoup" id="A0A5N4AKV4">
        <property type="interactions" value="2322"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AKV4"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17950">
        <property type="entry name" value="DEADc_DDX39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000111">
        <property type="entry name" value="DEAD-box ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000168">
        <property type="entry name" value="DEAD-box ATP-dependent RNA helicase 56-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="13">
        <location>
            <begin position="43"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="74"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="259"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="9">
        <location>
            <begin position="43"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAB0797982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="425" mass="48734" checksum="D7F482D9F69C2090" modified="2020-02-26" version="1">MADADDLLDYEDEENPEQNSAETPAATEQKKGVKGTYVSIHSSGFRDFLLKPEILRAIVDCGFEHPSEVQHECIPQAVLGMDILCQAKSGMGKTAVFVLATLQQLEPTENVVYVLVMCHTRELAFQISKEYERFSKYMPTIKVGVFFGGLPIQKDEELLKSNCPHIVVGTPGRILALVRSKKLNLKHIKHFILDECDKMLELLDMRRDVQEIYRNTPHGKQVMMFSATLSKDIRPVCKKFMQDPMEVYVDDEAKLTLHGLQQHYVKLKENEKNKKLFELLDVLEFNQVVIFVKSVQRCMALAQLLTEQNFPAIGIHRGMTQEERLSRYQQFKDFQKRILVATNLFGRGMDIERVNIVFNYDMPEDSDTYLHRVARAGRFGTKGLAITFVSEESDAKILNEVQDRFDVNITELPDEIDLSSYIEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AKY3</accession>
    <name>A0A5N4AKY3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_08959</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AKY3"/>
    <dbReference type="FunCoup" id="A0A5N4AKY3">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AKY3"/>
    <dbReference type="OrthoDB" id="2142683at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024405255" description="C-type lectin domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="159"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0797966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="311" mass="35675" checksum="D67B72F8B8C8C05D" modified="2020-02-26" version="1">MHLKLLIITLIAYNSNCVYLNSSKPTENNPAKWTESEIWGPIFEDWILTKNRRSSRVTHLIPIQSVYENDTSIIDRSDEEKESKIASNLKIVNSNPVRNKPPQRQVTETEMYLLNAIEKMVYKVDFMEKRLRRVEQMLYFVMAGNKVDQEPCADNFNRAGQNCYLFAGTAGRELDWKAASKQCNKYGAALAEMETIEENQDVISYIQSQDHLRGREYWTGGLNPGLLWIWSNSARPIKTPTAPNKQDADPGSHIPGNGRCLRLAYNPSLRSYGYKGTDCSTRYSYICEIAENSATNELRRLGRSRKIIDEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ALA1</accession>
    <name>A0A5N4ALA1_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_09092</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ALA1"/>
    <dbReference type="InParanoid" id="A0A5N4ALA1"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23992">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.20">
        <property type="entry name" value="Pheromone/general odorant binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006170">
        <property type="entry name" value="PBP/GOBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036728">
        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01395">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024467679" evidence="1">
        <location>
            <begin position="17"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0798099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="134" mass="15669" checksum="5119413CD124E036" modified="2020-02-26" version="1">MKAFILAFVLFYTCSAFKHNVHPDLVKSWDKMVGRHRERCIAETKVDKEDAMGAVLAMDLPEYYEYKCFAYCIWRESEFYNPQTKQLNYANIVRGVTGFTKENTKQCYKKYKNTGDHCERIYGIVTCGIGKLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AM32</accession>
    <name>A0A5N4AM32_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PPYR_09367</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AM32"/>
    <dbReference type="InParanoid" id="A0A5N4AM32"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015232">
        <property type="term" value="F:heme transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097037">
        <property type="term" value="P:heme export"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049680">
        <property type="entry name" value="FLVCR1-2_SLC49-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10924:SF4">
        <property type="entry name" value="GH15861P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10924">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="298"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="351"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="377"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="411"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="471"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="510"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0798374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="543" mass="59936" checksum="F3E07928DABED878" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AMD7</accession>
    <name>A0A5N4AMD7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_09467</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AMD7"/>
    <dbReference type="InParanoid" id="A0A5N4AMD7"/>
    <dbReference type="OrthoDB" id="10257471at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38926:SF5">
        <property type="entry name" value="F-BOX AND LEUCINE-RICH REPEAT PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38926">
        <property type="entry name" value="F-BOX DOMAIN CONTAINING PROTEIN, EXPRESSED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="12"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0798474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="411" mass="47461" checksum="99A18596DF1CA0E1" modified="2020-02-26" version="1">MSQTSCRSSSSPTWYHNLPSEILVRIFEHLEESEIRKSVMLVCRQWKFAATRPVLWKKLHIYGERVPTNFICQRIRCLPYLTTIHLREISEPAFIIRQIMRWLPKLKHFTLRNSGTVSETVLRNLIQRCRQLETLDISGTTFRGCKFYEEIAGLMNLRHINLSKNYSLNINNFMTALVNCHKLEELKVTTVLSDKETGRLSDTHVLFIISNFANNLTGLGLDASSLTDFSFKVVTQCTKLKTLSLHNARNLSPEVLLRIWKSLQNLNTLKVREANQIDGSTIAELFNSNRENLLRVTSIDLTGCWKINDAGIAAIANCRELERLRLKGCKSIQSLRPIRDSCTKLKKLNIAFCINLDPWTILPLPEKLNKLILDKSSRFSPIRHSMFAYDHVMVKVCLSEYNRSMENYTCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-06-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AME7</accession>
    <name>A0A5N4AME7_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_09477</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AME7"/>
    <dbReference type="InParanoid" id="A0A5N4AME7"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0798484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="115" mass="13545" checksum="95CA12D6A3C7B544" modified="2020-02-26" version="1">MHILFLPVGLQKIMGSFLRQSKSEICIIARWLSIFPLEKAVKLTFNSKISTTYGKVGKYRYTHFLIITLYANNISEKLRFIIQCTQTAHIMWITTIMIRDKTLPYFECFFPSTER</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ANI4</accession>
    <name>A0A5N4ANI4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_06785</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0798905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ANI4"/>
    <dbReference type="InParanoid" id="A0A5N4ANI4"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000182">
        <property type="entry name" value="Paired like homeobox 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050649">
        <property type="entry name" value="Paired_Homeobox_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24329:SF543">
        <property type="entry name" value="FI01017P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24329">
        <property type="entry name" value="HOMEOBOX PROTEIN ARISTALESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="129"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="131"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="189"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="195"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="267"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0798905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="354" mass="37847" checksum="191D957A94A67701" modified="2020-02-26" version="1">MDYSYLNQAAAAGFDSSCLQASAMDPTGLGNMPCSYGDLTSCSQMSQAAYRYTAAAASMARTYNPATAGAGAMVHHPGSTGSQCAVMGGRPHVQDVHHRAAMFPSTMNLQSGLPYKVYPGHDGVLTEKRKQRRIRTTFTSAQLKELERAFQETHYPDIYTREEIAMKIDLTEARVQVWFQNRRAKFRKQERLAQQKASNNSSDGNNTQSSVKSESNGPKSSINTKDIKPGSPHSGVSTTPNSNTSVSSHQSSNGDIKPMNGKLSEDSLGSNNNKWSSMSPQSCNTALLVHQANKVLSSQPSHLQLQTHSSHHAAAAAAAALSAPFSSLLGASGGAASYLLGDHLKPTAATNHLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AP84</accession>
    <name>A0A5N4AP84_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Peptidase M14 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PPYR_07035</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the peptidase M14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AP84"/>
    <dbReference type="FunCoup" id="A0A5N4AP84">
        <property type="interactions" value="159"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AP84"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06907">
        <property type="entry name" value="M14_AGBL2-3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000011">
        <property type="entry name" value="cytosolic carboxypeptidase 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050821">
        <property type="entry name" value="Cytosolic_carboxypeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040626">
        <property type="entry name" value="Pepdidase_M14_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12756">
        <property type="entry name" value="CYTOSOLIC CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12756:SF45">
        <property type="entry name" value="CYTOSOLIC CARBOXYPEPTIDASE NNA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18027">
        <property type="entry name" value="Pepdidase_M14_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M14" evidence="11">
        <location>
            <begin position="337"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="629"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="785"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="849"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="867"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="927"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="942"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAB0799155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="972" mass="111888" checksum="8F6B84246F11DD71" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AR80</accession>
    <name>A0A5N4AR80_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_07686</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AR80"/>
    <dbReference type="InParanoid" id="A0A5N4AR80"/>
    <dbReference type="OrthoDB" id="6782345at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0799806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="269" mass="30306" checksum="F99C59868465379D" modified="2020-02-26" version="1">MLALPIKFRILFGGPSVWLTTDKRQCWWPNSLNARPYMVKSEKPNEQWKLYDIEVEGYSSTLEGARKKAENPEYTSTQEDVTLAGRGHRKITKKQVSTDESSDECSPPPSPGCIPPSTRSTLRNNEADNLRGTTVCSSASEPLPTLSENSNETNFNYGAAVDDYVNSTEYIAVQEHTAVGAPLAIETVNINELPVHIEGNITVQDLHNSIDQLKYICLENQKCINDIYKILRNMSLKEGEINVSQKEKFCKWLPLVDLDKLKQLEDELN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-06-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ARA3</accession>
    <name>A0A5N4ARA3_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_07762</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ARA3"/>
    <dbReference type="InParanoid" id="A0A5N4ARA3"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024343409" evidence="1">
        <location>
            <begin position="17"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0799882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="133" mass="15617" checksum="EAF6022DABF91F8E" modified="2020-02-26" version="1">MFVLVLLLWRIVKVILKVFVNNIGYISNNMLFIECSCLPHVLKIYEQNKKILKLLEQQHHPLADVTFGDEFQFPLHTVEDVEQMENLISSDIGLQRRLVGIYIIYCKIICFQLCILGNATFQTGWEWSCFHNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ASJ4</accession>
    <name>A0A5N4ASJ4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Progestin and adipoQ receptor family member 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_06047</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ADIPOR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000004">
        <property type="protein sequence ID" value="KAB0800307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ASJ4"/>
    <dbReference type="FunCoup" id="A0A5N4ASJ4">
        <property type="interactions" value="399"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4ASJ4"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="ADIPOR/PROGESTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855:SF15">
        <property type="entry name" value="PROGESTIN AND ADIPOQ RECEPTOR FAMILY MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="159"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR604254-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0800307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="329" mass="37936" checksum="8DB97575E1A2D159" modified="2020-02-26" version="1">MQKRNDTSTDHTGSLLSACDDDENVNDPILEESESKCKKEICEHHKPNGEMRLYSLKDAPEYLQHNVFILTGYRGILNTKLCIESIFWWTNETINIWSHIFGWLLFVGLTIYDLSLLNLHASFLDKLCVAMLLICFQVCMGLSAVYHTFSCRSEDDCNYYLSLDLFGIALSLLAIYMSGIYYAFWCHQAMLNFYLVTIFLIFCGAMALQHPKLNANTNVKMFVFVLWAAYGIVPTIHWTFIMGGFANPLVSMLIPRVMGMYSISGTAFLIYLTKVPERFCAGKFDYLGHSHQWWHLFVVGALYYWHNTGIMYAEYRMNHGCATSLRLDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ATW2</accession>
    <name>A0A5N4ATW2_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Ionotropic glutamate receptor C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PPYR_06506</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">1611_PpyrPB1</strain>
            <tissue evidence="20">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000004">
        <property type="protein sequence ID" value="KAB0800767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ATW2"/>
    <dbReference type="FunCoup" id="A0A5N4ATW2">
        <property type="interactions" value="10"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4ATW2"/>
    <dbReference type="OrthoDB" id="5984008at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13717">
        <property type="entry name" value="PBP2_iGluR_putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000649">
        <property type="entry name" value="AGAP010272-PA-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000080">
        <property type="entry name" value="Glutamate receptor ionotropic, kainate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000142">
        <property type="entry name" value="Ionotropic receptor 25a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001508">
        <property type="entry name" value="Iono_Glu_rcpt_met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015683">
        <property type="entry name" value="Ionotropic_Glu_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18966">
        <property type="entry name" value="IONOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00177">
        <property type="entry name" value="NMDARECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00918">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00079">
        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="17" id="KW-0732">Signal</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024453369" description="Ionotropic glutamate receptor C-terminal domain-containing protein" evidence="17">
        <location>
            <begin position="26"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="556"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="631"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="852"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="18">
        <location>
            <begin position="432"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="19">
        <location>
            <begin position="442"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="517"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="767"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="site" description="Crucial to convey clamshell closure to channel opening" evidence="14">
        <location>
            <position position="661"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with the cone snail toxin Con-ikot-ikot" evidence="14">
        <location>
            <position position="688"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="779"/>
            <end position="837"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAB0800767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="22">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="934" mass="107037" checksum="D81D785B2BB65B21" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ATZ4</accession>
    <name>A0A5N4ATZ4_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PPYR_06429</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000004">
        <property type="protein sequence ID" value="KAB0800690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ATZ4"/>
    <dbReference type="InParanoid" id="A0A5N4ATZ4"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046949">
        <property type="term" value="P:fatty-acyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000007">
        <property type="entry name" value="4-coumarate--CoA ligase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF422">
        <property type="entry name" value="BCDNA.GH02901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="4">
        <location>
            <begin position="45"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="4">
        <location>
            <begin position="217"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="5">
        <location>
            <begin position="446"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0800690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="535" mass="59659" checksum="44A60B52AF678CF4" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AV16</accession>
    <name>A0A5N4AV16_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Catenin delta-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PPYR_05545</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the beta-catenin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000003">
        <property type="protein sequence ID" value="KAB0801191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AV16"/>
    <dbReference type="FunCoup" id="A0A5N4AV16">
        <property type="interactions" value="437"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AV16"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000336">
        <property type="entry name" value="Catenin delta-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028435">
        <property type="entry name" value="Plakophilin/d_Catenin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10372:SF27">
        <property type="entry name" value="ADHERENS JUNCTION PROTEIN P120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10372">
        <property type="entry name" value="PLAKOPHILLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="5" id="KW-0965">Cell junction</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="369"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="413"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="672"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="165"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="580"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="817"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="873"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="244"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="818"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="833"/>
            <end position="844"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0801191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="939" mass="103868" checksum="060BAD6166F13A09" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AW83</accession>
    <name>A0A5N4AW83_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CN hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_03785</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0801599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AW83"/>
    <dbReference type="InParanoid" id="A0A5N4AW83"/>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040154">
        <property type="entry name" value="Biotinidase/VNN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043957">
        <property type="entry name" value="Vanin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10609:SF14">
        <property type="entry name" value="BIOTINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10609">
        <property type="entry name" value="BIOTINIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19018">
        <property type="entry name" value="Vanin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024450598" description="CN hydrolase domain-containing protein" evidence="3">
        <location>
            <begin position="19"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="domain" description="CN hydrolase" evidence="4">
        <location>
            <begin position="23"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0801599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="528" mass="59724" checksum="C22E063143924566" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AXT9</accession>
    <name>A0A5N4AXT9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCDC174 alpha/beta GRSR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_04322</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AXT9"/>
    <dbReference type="FunCoup" id="A0A5N4AXT9">
        <property type="interactions" value="1003"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AXT9"/>
    <dbReference type="OrthoDB" id="333551at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025066">
        <property type="entry name" value="CCDC174-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057464">
        <property type="entry name" value="CCDC174_GRSR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15885">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 174"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15885:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 174"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25449">
        <property type="entry name" value="CCDC174_GRSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13300">
        <property type="entry name" value="DUF4078"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCDC174 alpha/beta GRSR" evidence="3">
        <location>
            <begin position="150"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="114"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="280"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="280"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="304"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="333"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="404"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="458"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0802136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="534" mass="62668" checksum="4D95D386D642439E" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AXV7</accession>
    <name>A0A5N4AXV7_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_04367</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AXV7"/>
    <dbReference type="InParanoid" id="A0A5N4AXV7"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0802181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="138" mass="15318" checksum="86305851919B8199" modified="2020-02-26" version="1">MMIKGPLMRYLVLNKKIQFRHGCCALVKTASIHTTRGFGGYKPSTCHPNSLFRFLGPSIRIAVLVIVLWGSACLFVTALVVQSVRTITGTHNYEVFDNFVQENAMDITILAIVELSLSIVTLLSVSLLARIDCKYDPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AXY6</accession>
    <name>A0A5N4AXY6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_04408</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AXY6"/>
    <dbReference type="FunCoup" id="A0A5N4AXY6">
        <property type="interactions" value="457"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AXY6"/>
    <dbReference type="OrthoDB" id="72772at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000323">
        <property type="term" value="C:lytic vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035493">
        <property type="term" value="P:SNARE complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018791">
        <property type="entry name" value="UV_resistance/autophagy_Atg14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15157">
        <property type="entry name" value="UV RADIATION RESISTANCE-ASSOCIATED GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15157:SF5">
        <property type="entry name" value="UV RADIATION RESISTANCE-ASSOCIATED GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10186">
        <property type="entry name" value="ATG14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="563"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0802222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="804" mass="90996" checksum="D9536003409B38CD" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AZ21</accession>
    <name>A0A5N4AZ21_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CHK kinase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_04719</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AZ21"/>
    <dbReference type="InParanoid" id="A0A5N4AZ21"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015897">
        <property type="entry name" value="CHK_kinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004119">
        <property type="entry name" value="EcKL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012:SF54">
        <property type="entry name" value="CHK KINASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012">
        <property type="entry name" value="PROTEIN KINASE-LIKE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02958">
        <property type="entry name" value="EcKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00587">
        <property type="entry name" value="CHK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHK kinase-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0802533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="282" mass="32464" checksum="64CF7E59879326EC" modified="2020-02-26" version="1">MDNMKSKGFVTGNHRVEVDYPHALLVMKELGKFHAMSLAMRDQKPGVFRHLQDNCQESFFNSDSFEPVLTMIKNLGNIVLESYDPIRDSLYIEPLKRSLSKVNDTFAGMRLQERYGEYAVINHGDAQMRNIMFKYGDSAHPSTPTELCLIDWQLAHVASPAFDILWFIFVCTGQEFRNRHYKQLLEEYYGSMSTLLRQLGSNAEKLLPFDVLMEHLRKFAPYGLYIAIWIAALNMKESANIPDLYNSSEDVIINHLSVAPSQAYMTKIRGVISDFIEYGYTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AZC4</accession>
    <name>A0A5N4AZC4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_04862</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AZC4"/>
    <dbReference type="InParanoid" id="A0A5N4AZC4"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd09275">
        <property type="entry name" value="RNase_HI_RT_DIRS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03714">
        <property type="entry name" value="RT_DIRS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052055">
        <property type="entry name" value="Hepadnavirus_pol/RT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050:SF7">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="12"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0802676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="577" mass="67160" checksum="4F9C5462FA79AD50" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AZQ4</accession>
    <name>A0A5N4AZQ4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">TATA box binding protein associated factor (TAF) histone-like fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_05027</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AZQ4"/>
    <dbReference type="InParanoid" id="A0A5N4AZQ4"/>
    <dbReference type="OrthoDB" id="6621890at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046695">
        <property type="term" value="C:SLIK (SAGA-like) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.770">
        <property type="entry name" value="TAF6, C-terminal HEAT repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037796">
        <property type="entry name" value="TAF6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046344">
        <property type="entry name" value="TAF6_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10221">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10221:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="29"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0802841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="539" mass="62495" checksum="E2AF82423A04B3A7" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AZU7</accession>
    <name>A0A5N4AZU7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase/retrotransposon-derived protein RNase H-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_05051</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AZU7"/>
    <dbReference type="InParanoid" id="A0A5N4AZU7"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008042">
        <property type="entry name" value="Retrotrans_Pao"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF4">
        <property type="entry name" value="PEPTIDASE S1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05380">
        <property type="entry name" value="Peptidase_A17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0802865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="307" mass="35074" checksum="91AC388ADB57E626" modified="2020-02-26" version="1" fragment="single">ELCNLEGKKFPLAARAVLHNTYVDDILAGGDTVEEVIQLRDELIQLLSNGSFELHKWCSNNPSILNGIPIELQHFDEREMNHDLIVKTLGLSFDVKLDMFKISSPKESITKANTKRKILSFLCKFYDPLGLVGPLFVSAKIIMQRLWLKKIDWDDILSDELLETWEEFVENLRKMEPINIPRYLQLNSHATSELVGFCDASMFAYGAVVYIRTVNETVTSTLLCSKSRIAPLNKKLTIPRLELNSALLLANVIHKVYSVLKKRINKVYLYSDSNIVLAWIKTNSVKLNPCGKQNNKDSRLNERYAMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B054</accession>
    <name>A0A5N4B054_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_05177</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B054"/>
    <dbReference type="InParanoid" id="A0A5N4B054"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041515">
        <property type="entry name" value="PPAF-2-like_Clip"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051487">
        <property type="entry name" value="Ser/Thr_Proteases_Immune/Dev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24256">
        <property type="entry name" value="TRYPTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18322">
        <property type="entry name" value="CLIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S1" evidence="3">
        <location>
            <begin position="92"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0802991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="351" mass="39226" checksum="1220C633AA4B46AC" modified="2020-02-26" version="1">MLIRSFFDYQSTSTKAPEPAEAECLCTPFYLCNNGEVNKDRSKLFEPRLAQKSVNPCKTLGEVCCEPLAPSPLRKKVKGIPFNFACGFGSEIPGDYNISDPTTATFGEYPWTALVLNLEYHYECVGSLIHPEVVLTTAHCINDSESYIALVKEWNTTGKTEPIAHQNMRVKSIVMHPKFVIHNLMYNAALLFLEKPFKLDRRVNTACLADSSTVSYNQLQKSKCAATGWGSDAPNGVYRRVMKKIEFSLISNRLCQIQLRKTGLGKWFQLHQTFLCATGKNGSGLCNGDEGGPLVCEISGQPLRYLQVGITSLRRDCAQNPSVFTKIASIKDWIDQEMSARNLDTSYYTPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B0L6</accession>
    <name>A0A5N4B0L6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_00063</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B0L6"/>
    <dbReference type="InParanoid" id="A0A5N4B0L6"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0803093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="139" mass="15615" checksum="D880FC15B7A0D613" modified="2020-02-26" version="1">MQNLRACPLVEFIHRRYITFPDTRASIGRNTMEFYEIARFPGVTGCIDGTHIPIRSPGGDRAEVFRNRKGYFSINCQATGNLSGLLLGDSAHAQSRFMFTPVPEPNNIADQAYNAAQVRTRNVVERTFGQWNNASVAYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B168</accession>
    <name>A0A5N4B168_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Papilin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PPYR_00276</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A5N4B168">
        <property type="interactions" value="14"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4B168"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048019">
        <property type="term" value="F:receptor antagonist activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050431">
        <property type="term" value="F:transforming growth factor beta binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00109">
        <property type="entry name" value="Kunitz-type"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="CDD" id="cd22639">
        <property type="entry name" value="Kunitz_papilin_lacunin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.410.10:FF:000020">
        <property type="entry name" value="Collagen, type VI, alpha 3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000107">
        <property type="entry name" value="Myosin, light chain kinase a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.410.10:FF:000005">
        <property type="entry name" value="Pancreatic trypsin inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.10">
        <property type="entry name" value="Pancreatic trypsin inhibitor Kunitz domain"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036645">
        <property type="entry name" value="Elafin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002223">
        <property type="entry name" value="Kunitz_BPTI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036880">
        <property type="entry name" value="Kunitz_BPTI_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010909">
        <property type="entry name" value="PLAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020901">
        <property type="entry name" value="Prtase_inh_Kunz-CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008197">
        <property type="entry name" value="WAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45938">
        <property type="entry name" value="ACP24A4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45938:SF11">
        <property type="entry name" value="WAP, KAZAL, IMMUNOGLOBULIN, KUNITZ AND NTR DOMAIN-CONTAINING PROTEIN 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00014">
        <property type="entry name" value="Kunitz_BPTI"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08686">
        <property type="entry name" value="PLAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19030">
        <property type="entry name" value="TSP1_ADAMTS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00095">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00759">
        <property type="entry name" value="BASICPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00131">
        <property type="entry name" value="KU"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00217">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57362">
        <property type="entry name" value="BPTI-like"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57256">
        <property type="entry name" value="Elafin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00280">
        <property type="entry name" value="BPTI_KUNITZ_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50279">
        <property type="entry name" value="BPTI_KUNITZ_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50900">
        <property type="entry name" value="PLAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51390">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="3" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="10">
        <location>
            <begin position="1618"/>
            <end position="1668"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="10">
        <location>
            <begin position="1677"/>
            <end position="1727"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="10">
        <location>
            <begin position="1736"/>
            <end position="1786"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="10">
        <location>
            <begin position="1798"/>
            <end position="1848"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="10">
        <location>
            <begin position="1876"/>
            <end position="1926"/>
        </location>
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    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="10">
        <location>
            <begin position="1933"/>
            <end position="1983"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="10">
        <location>
            <begin position="2013"/>
            <end position="2063"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="10">
        <location>
            <begin position="2072"/>
            <end position="2122"/>
        </location>
    </feature>
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        <location>
            <begin position="2220"/>
            <end position="2266"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="2291"/>
            <end position="2379"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="2387"/>
            <end position="2477"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="2547"/>
            <end position="2639"/>
        </location>
    </feature>
    <feature type="domain" description="PLAC" evidence="12">
        <location>
            <begin position="2645"/>
            <end position="2684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="363"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1319"/>
            <end position="1358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="2504"/>
            <end position="2529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="397"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="449"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="784"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="800"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="913"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1037"/>
            <end position="1171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAB0803306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2707" mass="292790" checksum="A566B82428E907BD" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B223</accession>
    <name>A0A5N4B223_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">OAR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_00573</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the paired homeobox family. Bicoid subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="InParanoid" id="A0A5N4B223"/>
    <dbReference type="Proteomes" id="UP000327044">
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    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003654">
        <property type="entry name" value="OAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043562">
        <property type="entry name" value="RAX/RAX2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46271">
        <property type="entry name" value="HOMEOBOX PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46271:SF4">
        <property type="entry name" value="HOMEOBOX PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03826">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50803">
        <property type="entry name" value="OAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
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        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
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    <feature type="domain" description="OAR" evidence="8">
        <location>
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            <end position="112"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="3"/>
            <end position="14"/>
        </location>
    </feature>
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        <location>
            <position position="1"/>
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    <evidence type="ECO:0000256" key="1">
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0803603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="122" mass="13425" checksum="BBF389FE13B38BBF" modified="2020-02-26" version="1" fragment="single">VWFQNRRAKWRRQEKMEAARLGLTDYHSVSTLTRVGGSSLGLPMDPWLSPPLLSALPGFLSHPQTGYPSYLTSPVAADHSRPPVAHSQSPTTSPDPRSTSIAALRLKAKEHVENITKGLQMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B2Q3</accession>
    <name>A0A5N4B2Q3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">U1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_00847</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A5N4B2Q3">
        <property type="interactions" value="563"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4B2Q3"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032446">
        <property type="entry name" value="SCAPER_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31434">
        <property type="entry name" value="S PHASE CYCLIN A-ASSOCIATED PROTEIN IN THE ENDOPLASMIC RETICULUM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31434:SF2">
        <property type="entry name" value="S PHASE CYCLIN A-ASSOCIATED PROTEIN IN THE ENDOPLASMIC RETICULUM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16501">
        <property type="entry name" value="SCAPER_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="U1-type" evidence="3">
        <location>
            <begin position="945"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="150"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="314"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="506"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="854"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="692"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="156"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="318"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="506"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="545"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="566"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="854"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="896"/>
            <end position="917"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0803877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1483" mass="166404" checksum="893D9F9EC7BD3832" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B313</accession>
    <name>A0A5N4B313_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 12">Glucose-6-phosphate 1-dehydrogenase</fullName>
            <ecNumber evidence="5 12">1.1.1.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PPYR_00926</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">1611_PpyrPB1</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Cytosolic glucose-6-phosphate dehydrogenase that catalyzes the first and rate-limiting step of the oxidative branch within the pentose phosphate pathway/shunt, an alternative route to glycolysis for the dissimilation of carbohydrates and a major source of reducing power and metabolic intermediates for fatty acid and nucleic acid biosynthetic processes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>D-glucose 6-phosphate + NADP(+) = 6-phospho-D-glucono-1,5-lactone + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15841"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="1.1.1.49"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:15842"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the glucose-6-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.49" evidence="5 12"/>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B313"/>
    <dbReference type="InParanoid" id="A0A5N4B313"/>
    <dbReference type="OrthoDB" id="60984at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00408"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004345">
        <property type="term" value="F:glucose-6-phosphate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009051">
        <property type="term" value="P:pentose-phosphate shunt, oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000111">
        <property type="entry name" value="Glucose-6-phosphate 1-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00966">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001282">
        <property type="entry name" value="G6P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022675">
        <property type="entry name" value="G6P_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022674">
        <property type="entry name" value="G6P_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00871">
        <property type="entry name" value="zwf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23429:SF0">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23429">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02781">
        <property type="entry name" value="G6PD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00479">
        <property type="entry name" value="G6PD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000110">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00079">
        <property type="entry name" value="G6PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7 12" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="8 12" id="KW-0521">NADP</keyword>
    <keyword evidence="9 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-6-phosphate dehydrogenase NAD-binding" evidence="13">
        <location>
            <begin position="32"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-6-phosphate dehydrogenase C-terminal" evidence="14">
        <location>
            <begin position="209"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAB0803956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="513" mass="59136" checksum="6E7D5D1DE4D0B9AA" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B399</accession>
    <name>A0A5N4B399_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Aftiphilin clathrin-binding box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_00978</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B399"/>
    <dbReference type="FunCoup" id="A0A5N4B399">
        <property type="interactions" value="26"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4B399"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030121">
        <property type="term" value="C:AP-1 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032588">
        <property type="term" value="C:trans-Golgi network membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046359">
        <property type="entry name" value="Aftin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029205">
        <property type="entry name" value="Clathrin-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16156">
        <property type="entry name" value="AFTIPHILIN A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16156:SF10">
        <property type="entry name" value="AFTIPHILIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15045">
        <property type="entry name" value="Clathrin_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aftiphilin clathrin-binding box" evidence="2">
        <location>
            <begin position="225"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="434"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0804008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="723" mass="80120" checksum="0DF546B50BE6A5DB" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B4A5</accession>
    <name>A0A5N4B4A5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transposase Helix-turn-helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_01395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B4A5"/>
    <dbReference type="InParanoid" id="A0A5N4B4A5"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0804425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="136" mass="16017" checksum="AC9D6A941F395EBB" modified="2020-02-26" version="1" fragment="single">MNRNLIASSALAASVIVIMSCLLTKRRNKRTRIWSRNWLQRRNEGRDVLNMLNTELLPEDPNAYTNFLRLTNDQFEYLLSLISNEICKQDTLMRECIPSRSKLEVTLRFLATGETYRSLMYTTRIHETTISRFIPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B4D5</accession>
    <name>A0A5N4B4D5_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_01383</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B4D5"/>
    <dbReference type="InParanoid" id="A0A5N4B4D5"/>
    <dbReference type="OrthoDB" id="6764596at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33480">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33480:SF1">
        <property type="entry name" value="TYR RECOMBINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="712"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0804413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="804" mass="92713" checksum="7B0D96D1056A5322" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B555</accession>
    <name>A0A5N4B555_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_01638</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B555"/>
    <dbReference type="InParanoid" id="A0A5N4B555"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF1">
        <property type="entry name" value="GAG-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0804668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="305" mass="35429" checksum="ABD941F7099297FD" modified="2020-02-26" version="1">MEKRFNVHTSKQTRKYFATCLPGIPQCYLCIVNHFERTISQKKSTNNLAVDLLRFLKHPITKDVEMFMGELPNDRLEPTFPLFPTGVDYGNPILIKLGYMRSGPTQKERIVFFICIAAKAIHLKMATSATFIACLQRFISRQLKILFNHRNRSKIGYFCAGEDIEWNIIPPRASHFGGEWKAGVKSMKLQYKRIVGNANLTYEETLTLLVQIENILNSRPINAMSNDPNDFNPLTPPHFLIARSLFRWERIVQIRQHLWKRRRKCNIGAVEIEMVQDKTKDCSRNVGAVERRQSAFIKMEIGTYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B582</accession>
    <name>A0A5N4B582_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_01686</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B582"/>
    <dbReference type="InParanoid" id="A0A5N4B582"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032063">
        <property type="entry name" value="MavL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16062">
        <property type="entry name" value="MavL-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024427793" evidence="1">
        <location>
            <begin position="22"/>
            <end position="1019"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0804716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1019" mass="113386" checksum="E46C8C24747984EB" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B5M7</accession>
    <name>A0A5N4B5M7_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_01630</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B5M7"/>
    <dbReference type="FunCoup" id="A0A5N4B5M7">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4B5M7"/>
    <dbReference type="OrthoDB" id="10264154at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="73"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="153"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0804660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="319" mass="35490" checksum="2CE827259D364A9A" modified="2020-02-26" version="1">MSLKESGKRLIPFAAAGLGIFQGLVWTILAILGIVSRFLVIDQISWITHSEKLSNTLTAIMQNDASDGPLTGVGLFAVTIVYLVMSVLWVILSSILFICTRAQRHDYLNGVRVAWGVLTLVICIYDVIVTGMLGANYKEYLDLYNSTHASGVLYVLIGYGTLFSLAARGYVLWIINLVASILMLRGELNQKTKANTDIYDSSTIDAFDEPRTPYPGHNNPAYGWENEQPKFDARPSSGNHDYPGGNNSRPQADRVAGLGKQGPKSYPQNILPAEQPNNYRYPTPHIPQPDYYPPQQSNPAMKRFPPPPPNPKFNRNERY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B6Q7</accession>
    <name>A0A5N4B6Q7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF4758 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_02252</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0805282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B6Q7"/>
    <dbReference type="InParanoid" id="A0A5N4B6Q7"/>
    <dbReference type="OrthoDB" id="8193595at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024355547" description="DUF4758 domain-containing protein" evidence="2">
        <location>
            <begin position="25"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="525"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="711"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="789"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="571"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="592"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="615"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="713"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="797"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="820"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="843"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="870"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="917"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="962"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="978"/>
            <end position="989"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0805282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1083" mass="123049" checksum="CAA962FCD9A5FB4B" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B6Y6</accession>
    <name>A0A5N4B6Y6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HECT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PPYR_02341</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0805371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B6Y6"/>
    <dbReference type="InParanoid" id="A0A5N4B6Y6"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="1 2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024389367" description="HECT domain-containing protein" evidence="4">
        <location>
            <begin position="18"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="5">
        <location>
            <begin position="327"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="243"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="273"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0805371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="469" mass="52503" checksum="47C2964D01893FE3" modified="2020-02-26" version="1">MYFIIVSLVTISRFIMAERVEEIVSQILNSSTLRNTLETAVRQATQGSSASPDSNPITSAVPPPLARNVATTTREELRRLFPTIRSTSAADQSNRMIASRTNNTRKRKRAHSPVHSNFCRDVLLLKSPRTILTLKGREKTKAFEQGFAFSKVKFNSGWNREEVNTAFRDLFQSLLADVEFELLIPMSGRLVKPNLPPGGELNGDTIRSIFNHKMIYIRPTVQLTTIDVTDYLACPDVLSDSSHEDVDIANPEANPASSESPNEIQDEHPALSLEQSETTSGTNEGHSESEMTLKSLLQNLNEQITEEGVTMFNIYREGIFDCCLRALKRSSFSPFHKISVNFSDIEGTGEGAVDAGGPSREMFRLVLNHIKESSMFCGSDKKYIRLDMRAMNERHYYAAGQMIALSLIHGGDGPHFFSQSFYSVLRQDIAEGFPTINDIDDHHIRDELNKLSNATDASVIQDIFHHSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B7R1</accession>
    <name>A0A5N4B7R1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MADF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_02576</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0805606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B7R1"/>
    <dbReference type="FunCoup" id="A0A5N4B7R1">
        <property type="interactions" value="7"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4B7R1"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21505">
        <property type="entry name" value="MADF DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21505:SF12">
        <property type="entry name" value="MADF DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00595">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51029">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MADF" evidence="1">
        <location>
            <begin position="18"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0805606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="287" mass="32511" checksum="DF841A25DF98CEB0" modified="2020-02-26" version="1">MHSFRVKQFVWTPDVTTVLIHLYEEHPCLYLTSCNSYKNKNVRNAAYNSITAELNKNLNKSLTVKDVQTKLHDLRTQYLSELGKIKKSKVSGTSSDEVYTPKWQYFEILAFIGQSTVVTEGESNIPASISGVPDSERETWSQSQYTEETYYTEGDGEQMETQENLEVVFDGTVAELNESEIVVENPTQVPPRASSAPPTTRMKQNKQKNTGFGELLASATKALDKIQTTSTAPKMPERLPGDNILFEQMIASEMDKIKDEEILDNLKMAIYSSLLNAKKEFRRSLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2024-01-24" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B7T7</accession>
    <name>A0A5N4B7T7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tyr recombinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_02622</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0805652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B7T7"/>
    <dbReference type="InParanoid" id="A0A5N4B7T7"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00397">
        <property type="entry name" value="DNA_BRE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="entry name" value="Intergrase catalytic core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="2">
        <location>
            <begin position="80"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0805652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="248" mass="29118" checksum="14FC781A5EFF63A7" modified="2020-02-26" version="1">MNSWPWIHLLRLCNRQKKCVQIYCPKSLERSTNTYMESLWNGDCEHCELSDMKVEDIKDFEGGVIITIPKTKTKILRTREELCKMKPTDIEFRNDVVVVFRKLRRAHPDHLPLHSITFSYWQKYQFDRFMKRKPCTQRYFLIYNNSKCVNTPVGINTIGKIPMKITQFLGLENPWTFTGHSFRRTSATILANHGEGLIGIKQLVGWKSSAVAESYIEDSLHNKAQLSKKIHSHEVHKRRIVKNNVKIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1JQS7</accession>
    <name>A0A1Y1JQS7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">GTP-binding protein Di-Ras2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PPYR_11480</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the small GTPase superfamily. Di-Ras family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01103095">
        <property type="protein sequence ID" value="JAV51564.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01103093">
        <property type="protein sequence ID" value="JAV51566.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0794641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1JQS7"/>
    <dbReference type="FunCoup" id="A0A1Y1JQS7">
        <property type="interactions" value="385"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1JQS7"/>
    <dbReference type="OrthoDB" id="265044at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000303">
        <property type="entry name" value="GTP-binding protein Di-Ras2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0636">Prenylation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="JAV51564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0794641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="196" mass="21877" checksum="7BD104BABABD50AA" modified="2017-08-30" version="1">MPEQSNDYRVVVFGAGGVGKSSLVLRFVKGTFRESYIPTIEDTYRQVISCNKNICTLQITDTTGSHQFPAMQRLSISKGHAFILVYSVSSRQSLEELRPIWELIREIKGPDLTQIPVMLVGNKCDESAELREVSTSEGQGEAGSWGVNFMETSAKTNHNVKQLFQELLNMEKTRNVSLQLGNKATGRVAKDKCDLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1JYN4</accession>
    <name>A0A1Y1JYN4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Round spermatid basic protein 1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_05727</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the round spermatid basic protein 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01097361">
        <property type="protein sequence ID" value="JAV54253.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000003">
        <property type="protein sequence ID" value="KAB0801373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1JYN4"/>
    <dbReference type="InParanoid" id="A0A1Y1JYN4"/>
    <dbReference type="OrthoDB" id="6020087at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
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                <person name="Shigenobu S."/>
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                <person name="Debat H.J."/>
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                <person name="Day J.C."/>
                <person name="Suvorov A."/>
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                <person name="Stanger-Hall K.F."/>
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        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="7"/>
    <dbReference type="EMBL" id="GEZM01095997">
        <property type="protein sequence ID" value="JAV55217.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01001524">
        <property type="protein sequence ID" value="KAB0790303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="FunCoup" id="A0A1Y1K8V9">
        <property type="interactions" value="2160"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1K8V9"/>
    <dbReference type="OrthoDB" id="331948at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12246">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="8">
        <location>
            <begin position="85"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="JAV55217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0790303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="392" mass="44803" checksum="E0565529561EBDE7" modified="2017-08-30" version="1">MCFGPFSRICHWGPLTALGIIKLITGVTLYCGSMWWPSTTWGGFFNTSFFMGMSGLTLYNFMSSMFHGPGYLPLLWRPVNEKECENLQWCGVCQGYKAPRSHHCRKCGRCVMKMDHHCPWINNCVGWGNHAHFTAFLFFAVVGCGHSSTILSFSLYRGINRTWYMYHNIQNVPIVHFGLYGLILTVFGLGLAVGVVLAVGMLLGLQLRAIIRNRTGIEDWILEKAIYRRKDTDDTFVFPYHLGLWRNVRQVLNVGCEPVGDGILWEVAEGCDQFTLTKEQLAQKTDKRHRTKLYNILYPASGAWFPITKGLRVFLSIPCTDEPRIKLKQGDVVIVSRWRKHWLFGEKIQAQLDASEQSIARVRGWFPRKCAVELVDSSSTNSQLNFQDKKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1KAB6</accession>
    <name>A0A1Y1KAB6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PPYR_01107</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01087893">
        <property type="protein sequence ID" value="JAV58413.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1KAB6"/>
    <dbReference type="FunCoup" id="A0A1Y1KAB6">
        <property type="interactions" value="215"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1KAB6"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090734">
        <property type="term" value="C:site of DNA damage"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:ubiquitin protein ligase activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
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    </dbReference>
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        <property type="entry name" value="TRAIP_ubiq-protein_ligase"/>
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        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46569:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RFWD3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46569">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRAIP"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1 3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="5"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="342"/>
            <end position="384"/>
        </location>
    </feature>
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            <begin position="84"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="JAV58413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0804137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="409" mass="46586" checksum="36B627029F7A2DA7" modified="2017-08-30" version="1">MNLKCLICSDLLTPYSEIFGTTCGHLFHYHCLIQWIERSKTCPQCRFKATEKTIFKIYLTVEENTETVDLAVLHNKLDNLQFQINLKNLDVKNTKEKNETLRKQNLALIEENKEQENKLRVMESAMFALKEQVTYFKTKSKEAKKLETDLLELQGKLDRIKNVELVLAGTQDEVNSMLRNNQDPQSLSILVATLKKELIESDKSKKQLKGAIKTVQAESVAYRKKFQELRDASVHMREELESHKGCETERQYLKGKLAEFQNKYNRLSLETANNVNRIVSESPIPISRLTEPNTSSPSVPEVVETIAQSNSPYLRVQTSSIGLSGLLTYNNLSAGPNKTSILKQHPLQKETLKRPSISYDGLGGHSKDDDFPSPRSSLPFKKPKISVTTTARKFKKLAPQPKLSFQKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1KJY0</accession>
    <name>A0A1Y1KJY0_PHOPY</name>
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            <fullName evidence="2">Ubiquitin carboxyl-terminal hydrolase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PPYR_13205</name>
    </gene>
    <organism evidence="5">
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        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
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        <lineage>
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            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 2">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="EMBL" id="GEZM01081310">
        <property type="protein sequence ID" value="JAV61712.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1KJY0"/>
    <dbReference type="FunCoup" id="A0A1Y1KJY0">
        <property type="interactions" value="112"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1KJY0"/>
    <dbReference type="OrthoDB" id="265776at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02674">
        <property type="entry name" value="Peptidase_C19R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000046">
        <property type="entry name" value="ubiquitin carboxyl-terminal hydrolase 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF14">
        <property type="entry name" value="FI05488P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="4">
        <location>
            <begin position="133"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="24"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="JAV61712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0793585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="982" mass="110632" checksum="E075EC22BC834150" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1KRF1</accession>
    <name>A0A1Y1KRF1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">TGF-beta family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PPYR_05308</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the TGF-beta family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01080869">
        <property type="protein sequence ID" value="JAV62016.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000003">
        <property type="protein sequence ID" value="KAB0800954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1KRF1"/>
    <dbReference type="FunCoup" id="A0A1Y1KRF1">
        <property type="interactions" value="61"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1KRF1"/>
    <dbReference type="OrthoDB" id="6516235at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13752">
        <property type="entry name" value="TGF_beta_INHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001839">
        <property type="entry name" value="TGF-b_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001111">
        <property type="entry name" value="TGF-b_propeptide"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015615">
        <property type="entry name" value="TGF-beta-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017948">
        <property type="entry name" value="TGFb_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11848:SF298">
        <property type="entry name" value="DAWDLE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11848">
        <property type="entry name" value="TGF-BETA FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00019">
        <property type="entry name" value="TGF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00688">
        <property type="entry name" value="TGFb_propeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00669">
        <property type="entry name" value="INHIBINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00204">
        <property type="entry name" value="TGFB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00250">
        <property type="entry name" value="TGF_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51362">
        <property type="entry name" value="TGF_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 6" id="KW-0339">Growth factor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033289624" description="TGF-beta family profile domain-containing protein" evidence="7">
        <location>
            <begin position="24"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="TGF-beta family profile" evidence="8">
        <location>
            <begin position="292"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="JAV62016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0800954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="412" mass="46770" checksum="41DFDF0F4705CB87" modified="2017-08-30" version="1">MCHLVYVVGFVLALSSQTWICSGNSRTRSLFGATFDARPPASTINADSASELCLGCSQKYFEVDQDHVQQRYTVTEEELTALRIEYIKNQILKKLRLKTKPNVSIANLPKPVTEDENLVPRGYDQSTPSPFDDYYGRTTQAIVFPYEEQARCMKKVRHPSVCLPFQLPSDIHAIDLSTAELWIYKEPDELDGNGQTFVVTEVAHWDTKKSFQKTTPIAIHHTNLTEGWIKIDVAQVIRNWLDYQDSPIHAINVACKTCAKELKNSPVSFKNQHKPFLVIYTHSQQKQLAYRRQKRNTNCSPNMNECCRESLYVSFADIGWDDWIIQPAGYNAYFCRGSCNTVASVTLSATQHSSIMQKVLHGPNRNNVRKLELTPCCAATKFQPLQLFYMGNNKTLTSKVLSNMIVETCGCM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1KWK5</accession>
    <name>A0A1Y1KWK5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Condensin-2 complex subunit H2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_04910</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01071506">
        <property type="protein sequence ID" value="JAV65742.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
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    <dbReference type="EMBL" id="GEZM01071505">
        <property type="protein sequence ID" value="JAV65744.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
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        <property type="protein sequence ID" value="KAB0802724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="10038475at2759"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CNDH2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Condensin-2 complex subunit H2 C-terminal" evidence="1">
        <location>
            <begin position="759"/>
            <end position="860"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="JAV65742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0802724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="900" mass="100723" checksum="E0CEFD37DA1D72D1" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1L636</accession>
    <name>A0A1Y1L636_PHOPY</name>
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        <recommendedName>
            <fullName evidence="17">Agenet-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PPYR_06253</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="19 20" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">1611_PpyrPB1</strain>
            <tissue evidence="19">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">1611_PpyrPB1</strain>
            <tissue evidence="19">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Neuron projection</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Stress granule</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Perikaryon</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Synapse</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the FMR1 family.</text>
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        <property type="protein sequence ID" value="JAV68278.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
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        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0003730">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:animal organ development"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of long-term neuronal synaptic plasticity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:regulation of mRNA stability"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:regulation of translation at presynapse, modulating synaptic transmission"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22425">
        <property type="entry name" value="KH_I_FMR1_FXR_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22427">
        <property type="entry name" value="KH_I_FMR1_FXR_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20402">
        <property type="entry name" value="Tudor_Agenet_FMRP-like_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fragile X mental retardation 1, isoform CRA_e"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fragile X mental retardation protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040148">
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    </dbReference>
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    <dbReference type="InterPro" id="IPR040472">
        <property type="entry name" value="FMRP_KH0"/>
    </dbReference>
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        <property type="entry name" value="KH_dom"/>
    </dbReference>
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        <property type="entry name" value="KH_dom_type_1"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR10603">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10603:SF7">
        <property type="entry name" value="FRAGILE X MESSENGER RIBONUCLEOPROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FXMRP1_C_core"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17904">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18336">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
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    </dbReference>
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        <property type="entry name" value="AGENET_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0678">Repressor</keyword>
    <keyword evidence="13" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="9 15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="11" id="KW-0770">Synapse</keyword>
    <keyword evidence="8" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="Agenet-like" evidence="17">
        <location>
            <begin position="6"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="Agenet-like" evidence="17">
        <location>
            <begin position="63"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="385"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="385"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="16">
        <location>
            <begin position="409"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="436"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="473"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="493"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="JAV68278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAB0800513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="561" mass="63341" checksum="A7BB715EE3F7ECD6" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1L748</accession>
    <name>A0A1Y1L748_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_02827</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
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                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
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        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
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        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
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    </dbReference>
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        <property type="match status" value="7"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAB0791027.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="552" mass="62762" checksum="048591837C9EF80E" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1L7L4</accession>
    <name>A0A1Y1L7L4_PHOPY</name>
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            <fullName evidence="8">Uracil phosphoribosyltransferase homolog</fullName>
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        <name evidence="11" type="ORF">PPYR_09377</name>
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            <taxon>Coleoptera</taxon>
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            <taxon>Elateroidea</taxon>
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    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
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            <dbReference type="DOI" id="10.1038/srep38556"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
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            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
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    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
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        </source>
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        <subcellularLocation>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Transcribed_RNA"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-KW"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF14681"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="JAV69682.1"/>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
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        </source>
    </evidence>
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</entry>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
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            <dbReference type="DOI" id="10.1038/srep38556"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
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            <dbReference type="PubMed" id="30324905"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
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    <reference evidence="3" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
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        <property type="molecule type" value="Transcribed_RNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <location>
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            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036029822" evidence="1">
        <location>
            <begin position="20"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="JAV68516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0804953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="144" mass="16398" checksum="06F88C60F7CA4F04" modified="2017-08-30" version="1">MSTSFTVICFFATILGVSAICSFNFDDVLRKCGDLHGYDPNTVAKNYLTEYSEDEGPKFREFLDCAWTGWRFLRNAEVDFDAIKSKKVEPLLVTGVCDDVLQSSRPTDPFIDAVDTCEDSLPADIRSENARRCITKEYQKNIWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LE21</accession>
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        <recommendedName>
            <fullName evidence="6">Protein pinocchio</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_01860</name>
        <name evidence="2" type="ORF">PPYR_12956</name>
        <name evidence="3" type="ORF">PPYR_12958</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2 5" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01058107">
        <property type="protein sequence ID" value="JAV71899.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="JAV71900.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1LE21"/>
    <dbReference type="InParanoid" id="A0A1Y1LE21"/>
    <dbReference type="OrthoDB" id="10062522at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="JAV71899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0793336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0793338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0804890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="146" mass="15911" checksum="D9409B18A4DB93AF" modified="2017-08-30" version="1">MSLVGVHPRGYHSNSGSLSSFSYSLDDITTCCSPQFNSEHVLTIEELRLQMSSCFTCGVSWVEDHVSLDCSECGGYAMERPCPKCDGTCGSLWKRDLTKTHSSSKAQWEGECKRAATKPQPPKSFVSSTAATHEVCAKLEKLAAHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LHF4</accession>
    <name>A0A1Y1LHF4_PHOPY</name>
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        <recommendedName>
            <fullName evidence="2">ADP-ribosylation factor 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PPYR_09288</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01055251">
        <property type="protein sequence ID" value="JAV73063.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01055250">
        <property type="protein sequence ID" value="JAV73064.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1LHF4"/>
    <dbReference type="FunCoup" id="A0A1Y1LHF4">
        <property type="interactions" value="1559"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1LHF4"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051649">
        <property type="term" value="P:establishment of localization in cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="Arf6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000286">
        <property type="entry name" value="ADP-ribosylation factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041838">
        <property type="entry name" value="Arf6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0519">Myristate</keyword>
    <keyword evidence="5 9 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="20"/>
            <end position="27"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="44"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
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        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
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    </feature>
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        <location>
            <begin position="122"/>
            <end position="125"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="JAV73064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAB0798295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="175" mass="20108" checksum="81DC2E1E38EEB8EA" modified="2017-08-30" version="1">MGKLLSKIFGNKEMRILMLGLDAAGKTTILYKLKLGQSVTTIPTVGFNVETVTYKNVKFNVWDVGGQDKIRPLWRHYYTGTQGLIFVVDCADRDRIDEARQELHRIINDREMRDAIILIFANKQDLPEAMKPHEIQEKLGLTRIRDRNWYVQPACATTGDGLYEGLTWLTSNHKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LHI4</accession>
    <name>A0A1Y1LHI4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">40S ribosomal protein S8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_08911</name>
        <name evidence="10" type="ORF">PPYR_08913</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the eukaryotic ribosomal protein eS8 family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01059548">
        <property type="protein sequence ID" value="JAV71435.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1LHI4"/>
    <dbReference type="FunCoup" id="A0A1Y1LHI4">
        <property type="interactions" value="1098"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1LHI4"/>
    <dbReference type="OrthoDB" id="1703270at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11380">
        <property type="entry name" value="Ribosomal_S8e_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.70:FF:000004">
        <property type="entry name" value="40S ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.70:FF:000005">
        <property type="entry name" value="40S ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001047">
        <property type="entry name" value="Ribosomal_eS8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018283">
        <property type="entry name" value="Ribosomal_eS8_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022309">
        <property type="entry name" value="Ribosomal_Se8/biogenesis_NSA2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00307">
        <property type="entry name" value="eS8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10394">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01201">
        <property type="entry name" value="Ribosomal_S8e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01193">
        <property type="entry name" value="RIBOSOMAL_S8E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="JAV71435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0797918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0797920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="208" mass="23847" checksum="2D2C719AF8F72A1D" modified="2017-08-30" version="1">MGISRDHWHKRRATGGKRKPLRKKRKFELGRPAANTKLGARRIHYVRTRGGNLKYRALRLDHGNFGWGSEGIARSTRIIDVVYNASNNELVRTKTLVKNAIVVVDATPFRQWYEGHYILPLGRKKGAKLSEAEEAVLNKKRSKKVTRKYTTRQRTAKVEPALEEQFQTGRILACLASRPGQCGRADGYILEGKELEFYMRKIKSKKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LHN7</accession>
    <name>A0A1Y1LHN7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">N-acetylneuraminate lyase</fullName>
            <ecNumber evidence="5">4.1.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PPYR_01316</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>aceneuramate = aldehydo-N-acetyl-D-mannosamine + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:23296"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:17122"/>
            <dbReference type="ChEBI" id="CHEBI:173083"/>
            <dbReference type="EC" id="4.1.3.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-sugar metabolism; N-acetylneuraminate degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DapA family. NanA subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.3" evidence="5"/>
    <dbReference type="EMBL" id="GEZM01055082">
        <property type="protein sequence ID" value="JAV73162.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1LHN7"/>
    <dbReference type="InParanoid" id="A0A1Y1LHN7"/>
    <dbReference type="OrthoDB" id="191315at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008747">
        <property type="term" value="F:N-acetylneuraminate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="DIHYDRODIPICOLINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128:SF21">
        <property type="entry name" value="N-ACETYLNEURAMINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0704">Schiff base</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="29"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="JAV73162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAB0804346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="454" mass="51951" checksum="612E4D1B9AFE55E5" modified="2017-08-30" version="1">MESVLEVFVRDDDVETQVEPHSIKELFTDEYQSSPTFDLEDGSNGSDTSQPDEAVKLNPKKRKIKLDSGYPKKRFYSQKYRKEWETVPAYKPWLSESVLGRHYFYCKFCKNNNKCGRTEIEKHMACRKHIRNSTIPQYRVQKKFTFRGLLCSVFTPFKNRENDINYMVIPNYAKYLLACGVKGILLNDVVGEGMSLTVAERIRVLEEWMKICEKTKQFLMVQIGGAAFKDVQEMVKHAERKKVDAIVVLPDLYNKPKDHFDLMRYIKLVSDCATTIPLLYHHYPSYTGVNIDMAKFLSDILGEIDSFVGIIYNDNNLKDATLSLLVNPNKFTVFIGADEIVLGACASGFSSIMATSLNFVSHIVQSIYNDLKSGKIDDAQKCQNMLNNILECIYRQGDMLPTLKSAMNLLSPIDVGPVRDPLVPVWQDKVYKMKLELQDFDVFSSNATVKTECL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LJ75</accession>
    <name>A0A1Y1LJ75_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_13321</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
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                <person name="Fallon T.R."/>
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                <person name="Weng J.-K."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </reference>
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        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
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        <location>
            <begin position="16"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="JAV72931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0793701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="126" mass="14762" checksum="32577C26426D3B96" modified="2017-08-30" version="1">MKILLTLCLISSIHAINQVDTFLRRPTCVCTGKITAIMHDINGAYCMYYGTGVYRKWECENTEDWDQFLRSTPRRVAEPTCQCTSTATGIMQDETGTYCVYNGVDKRTRWECENTEEWDLYKRNRY</sequence>
</entry>
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    <name>A0A1Y1LJT0_PHOPY</name>
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        <recommendedName>
            <fullName evidence="9">Polycomb protein esc</fullName>
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        <alternativeName>
            <fullName evidence="10">Protein extra sex combs</fullName>
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        <name evidence="14" type="ORF">PPYR_04504</name>
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        <name type="scientific">Photinus pyralis</name>
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            <taxon>Neoptera</taxon>
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            <taxon>Coleoptera</taxon>
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    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
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                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
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            <dbReference type="DOI" id="10.1038/srep38556"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
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        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
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                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
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                <person name="Weng J.-K."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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</entry>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
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                <person name="Bessho-Uehara M."/>
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                <person name="Bewick A.J."/>
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                <person name="Debat H.J."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
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                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
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            <dbReference type="PubMed" id="28004739"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
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        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
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                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
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                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
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                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
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        <source>
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</entry>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
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            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
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            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
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                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
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            <dbReference type="PubMed" id="28004739"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
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                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
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                <person name="Day J.C."/>
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                <person name="Stanger-Hall K.F."/>
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                <person name="Schmitz R.J."/>
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                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
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                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Photinus pyralis genome working group"/>
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                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 14">
            <text>N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + 2 2-oxoglutarate + 2 O2 = L-lysyl(9)-[histone H3] + 2 formaldehyde + 2 succinate + 2 CO2</text>
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            <dbReference type="Rhea" id="RHEA-COMP:15541"/>
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            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
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            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
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        </reaction>
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        <subcellularLocation>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Putative lysine-specific demethylase 3B"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
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        <property type="entry name" value="LSDs-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12549:SF38">
        <property type="entry name" value="JMJC DOMAIN-CONTAINING HISTONE DEMETHYLASE 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12549">
        <property type="entry name" value="JMJC DOMAIN-CONTAINING HISTONE DEMETHYLATION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="10">
        <location>
            <begin position="1715"/>
            <end position="1920"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
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    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
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        <location>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="9">
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        <source>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
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                <person name="Weng J.K."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
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                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
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                <person name="Sander Lower S.E."/>
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    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
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            <dbReference type="DOI" id="10.1038/srep38556"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
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                <person name="Bessho-Uehara M."/>
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                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
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                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
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                <person name="Oba Y."/>
                <person name="Weng J.K."/>
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            <dbReference type="PubMed" id="30324905"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
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                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="7">1611_PpyrPB1</strain>
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        </source>
    </reference>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
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        <location>
            <begin position="299"/>
            <end position="335"/>
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        <location>
            <begin position="1"/>
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        <location>
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        <location>
            <begin position="1105"/>
            <end position="1130"/>
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    </feature>
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        <location>
            <begin position="1"/>
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        <location>
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            <begin position="1115"/>
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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        <source>
            <dbReference type="Pfam" id="PF11502"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAB0801550.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
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    <sequence length="1130" mass="119090" checksum="AC4189213BC46457" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
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                <person name="Al-Wathiqui N."/>
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                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
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        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
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                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </reference>
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            <end position="115"/>
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        </source>
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        </source>
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</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
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    <name>A0A1Y1MB63_PHOPY</name>
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    </gene>
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        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
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            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
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            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
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            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
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                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
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                <person name="Debat H.J."/>
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                <person name="Schmitz R.J."/>
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                <person name="Shigenobu S."/>
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            <dbReference type="PubMed" id="30324905"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">1611_PpyrPB1</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">1611_PpyrPB1</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Forms the polymerase active center together with the second largest subunit. A single-stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol III. A bridging helix emanates from RPC1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol III by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition.</text>
    </comment>
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        <reaction evidence="12 14">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
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            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
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            <dbReference type="ChEBI" id="CHEBI:61557"/>
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        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.</text>
    </comment>
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        </subcellularLocation>
    </comment>
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    <dbReference type="EMBL" id="GEZM01036154">
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        <property type="molecule type" value="Transcribed_RNA"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB1"/>
        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA' N-TERMINAL SECTION"/>
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    </dbReference>
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        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA' N-TERMINAL SECTION"/>
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    </dbReference>
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        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNA_pol_Rpb1_2"/>
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    </dbReference>
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        <property type="entry name" value="RNA_pol_Rpb1_3"/>
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    </dbReference>
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        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 14" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 14" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase N-terminal" evidence="15">
        <location>
            <begin position="256"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00058108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="JAV82934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAB0796390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1390" mass="154717" checksum="8C4C15CCB512E979" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1MBA2</accession>
    <name>A0A1Y1MBA2_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_03053</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01036989">
        <property type="protein sequence ID" value="JAV82285.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01036988">
        <property type="protein sequence ID" value="JAV82287.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01036987">
        <property type="protein sequence ID" value="JAV82288.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01036986">
        <property type="protein sequence ID" value="JAV82291.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1MBA2"/>
    <dbReference type="InParanoid" id="A0A1Y1MBA2"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35385:SF2">
        <property type="entry name" value="PROTEIN B, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35385">
        <property type="entry name" value="PROTEIN B, PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="JAV82288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0791253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="140" mass="16372" checksum="EDDEE0DA02F77338" modified="2017-08-30" version="1">MSTLEEGLRILFTELDQHSKIIKYENVISDDNFSVSLRTKLSNESTWSKACDRWVERFTVQTNSKWVVKYTFPKTLRMAYRKVYICKENSVASRNRNKSCKAKIDIRIKKVTESALKKDSLLRTGYNGDIKVVFSHSHSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1MND7</accession>
    <name>A0A1Y1MND7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UDP-glucose 4-epimerase</fullName>
            <ecNumber evidence="6">5.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_01789</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>UDP-N-acetyl-alpha-D-glucosamine = UDP-N-acetyl-alpha-D-galactosamine</text>
            <dbReference type="Rhea" id="RHEA:20517"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:67138"/>
            <dbReference type="EC" id="5.1.3.7"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>UDP-alpha-D-glucose = UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:22168"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="5.1.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 6">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.2" evidence="6"/>
    <dbReference type="EMBL" id="GEZM01026181">
        <property type="protein sequence ID" value="JAV87171.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01026180">
        <property type="protein sequence ID" value="JAV87172.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1MND7"/>
    <dbReference type="InParanoid" id="A0A1Y1MND7"/>
    <dbReference type="OrthoDB" id="9402762at2759"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003978">
        <property type="term" value="F:UDP-glucose 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003974">
        <property type="term" value="F:UDP-N-acetylglucosamine 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose, Leloir pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05247">
        <property type="entry name" value="UDP_G4E_1_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005886">
        <property type="entry name" value="UDP_G4E"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01179">
        <property type="entry name" value="galE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007956">
        <property type="entry name" value="PRK10675.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43725">
        <property type="entry name" value="UDP-GLUCOSE 4-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43725:SF31">
        <property type="entry name" value="UDP-GLUCOSE 4-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="5 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3 6" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="7">
        <location>
            <begin position="7"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="JAV87171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0804819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="362" mass="40799" checksum="6266F697D823C474" modified="2017-08-30" version="1">MAQFETVFVTGGAGYIGSHTIVELLNANYEVIVIDNFVNSVDEPNGESAALRRVEKITGKTVTFYKCDLLDRTALFDIFEKHKIDCVIHFAAIKAVGESMEYPLLYYKNNLIGMLNLLEVMERHECYQLVFSSSCTIYGEPKQLPITEDHEIGGNITNVYGKTKYFIEEMLADISHSNKKWNIICLRYFNPVGAHPSGEIGEDPTKAFSNIMPYIAQVAIGHKPILTIFGGDYNTSDGTGVRDYIHVMDLATGHVAALRKLCREHQHLKAYNLGTGRGVTVLELVKTFEKVTGAAVPFRIMEKREGDITAMFANADLADQELEWKAKHTLEEMCIDFWRWQTKNPYGYRPNKSSKITNGHGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1MPC6</accession>
    <name>A0A1Y1MPC6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_08135</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01025275">
        <property type="protein sequence ID" value="JAV87529.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1MPC6"/>
    <dbReference type="FunCoup" id="A0A1Y1MPC6">
        <property type="interactions" value="394"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1MPC6"/>
    <dbReference type="OrthoDB" id="75724at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902936">
        <property type="term" value="F:phosphatidylinositol bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1200">
        <property type="entry name" value="Alpha-tocopherol transfer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.20">
        <property type="entry name" value="N-terminal domain of phosphatidylinositol transfer protein sec14p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174">
        <property type="entry name" value="ALPHA-TOCOPHEROL TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174:SF212">
        <property type="entry name" value="MIP26555P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00180">
        <property type="entry name" value="CRETINALDHBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="92"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="JAV87529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0797141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="286" mass="32856" checksum="371C5FA62C834BD2" modified="2017-08-30" version="1">MAFTLEVGPLTDEVKEFAKVDIRETPENVAQGLKELKELLQNDPTLNFSTDDEFLLIFLRPCKFYAKSAYELMKRIADFKQKHKDLIGNLMPEDEKAGFINNNVVNVLKNRDHKGRRVLIQNCGSLWDTSKVSADNVFRMLYLMHEAACLEPETQVRGGVVILDFDGLSTKQVMAFTPAISMRLLTFIQDAMPLRLKEVHIVKQPFIFNMVWTIFKPFIKEKLKGRLFFHGSKMSSLHKHLEPSCLPKNYGGDLPEMDYTGADWYPAIENHLDHMRLMNSCGLAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1MPP9</accession>
    <name>A0A1Y1MPP9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glutaredoxin-2, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PPYR_12917</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Glutathione-dependent oxidoreductase that facilitates the maintenance of mitochondrial redox homeostasis upon induction of apoptosis by oxidative stress. Involved in response to hydrogen peroxide and regulation of apoptosis caused by oxidative stress. Acts as a very efficient catalyst of monothiol reactions because of its high affinity for protein glutathione-mixed disulfides. Can receive electrons not only from glutathione (GSH), but also from thioredoxin reductase supporting both monothiol and dithiol reactions. Efficiently catalyzes both glutathionylation and deglutathionylation of mitochondrial complex I, which in turn regulates the superoxide production by the complex. Overexpression decreases the susceptibility to apoptosis and prevents loss of cardiolipin and cytochrome c release.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer; active form. Homodimer; inactive form. The homodimer is probably linked by 1 2Fe-2S cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutaredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01029795">
        <property type="protein sequence ID" value="JAV85925.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01029794">
        <property type="protein sequence ID" value="JAV85926.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1MPP9"/>
    <dbReference type="FunCoup" id="A0A1Y1MPP9">
        <property type="interactions" value="689"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1MPP9"/>
    <dbReference type="OrthoDB" id="418495at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015038">
        <property type="term" value="F:glutathione disulfide oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03419">
        <property type="entry name" value="GRX_GRXh_1_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000026">
        <property type="entry name" value="Glutaredoxin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011767">
        <property type="entry name" value="GLR_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011899">
        <property type="entry name" value="Glutaredoxin_euk/vir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014025">
        <property type="entry name" value="Glutaredoxin_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02180">
        <property type="entry name" value="GRX_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694">
        <property type="entry name" value="GLUTAREDOXIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694:SF5">
        <property type="entry name" value="GLUTAREDOXIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00160">
        <property type="entry name" value="GLUTAREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00195">
        <property type="entry name" value="GLUTAREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6" id="KW-0318">Glutathionylation</keyword>
    <keyword evidence="7" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="11">
        <location>
            <begin position="28"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00039819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="JAV85926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAB0793297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="112" mass="12402" checksum="760EDAD9286F2B2E" modified="2017-08-30" version="1">MGLFSSKIIDMSSPKAALVKELISSDKVVIFSKTYCPYCKLAKEVFDKLQQKYTAIELDERSDAEEIQLILGEMTGAKTVPRVFVKGECLGGGSDVKALYDNGKLMHYFNAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1MW52</accession>
    <name>A0A1Y1MW52_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_01224</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
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                <person name="Bessho-Uehara M."/>
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                <person name="Shigenobu S."/>
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        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0865">Zymogen</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="Cathepsin propeptide inhibitor" evidence="9">
        <location>
            <begin position="34"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="8">
        <location>
            <begin position="134"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="JAV92281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0799852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="350" mass="40198" checksum="B11659426B64329A" modified="2017-08-30" version="1">MNWYNLFLTVAFIFFLFCYIPITIKKTSNSHGDFNRFLERYNKTYDDDKQYQEHYAAFKNSTDSIAKLNNNRKSKLSALYGLTKFSDMTESEFKDRYLQSDLPTRITNRKLRRSRDGGRHKHHHRNKRATTTTIPLKFDWRERGIVTKVNNQKKCGACWAFSTVQNMESMYALKYKNLTSLSVQQAIDCARYDNDGCNGGDDCTFLQWLKDYSVKVYSDSTYPLHLKNEVCKLNNDSFFVQVDKYACDSFVDDEAYIVQAIATIGPVAVAVNAISWQHYVGGIIQFHCGGDFDLLNHSVQLVGYDLTADIPYYIARNSWGEDFGDKGYLYLAIGDNLCGLANEVSALTVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1N6S8</accession>
    <name>A0A1Y1N6S8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein mL43</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_04031</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL43 family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01011226">
        <property type="protein sequence ID" value="JAV93583.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0801845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1N6S8"/>
    <dbReference type="FunCoup" id="A0A1Y1N6S8">
        <property type="interactions" value="703"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1N6S8"/>
    <dbReference type="OrthoDB" id="88at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000257">
        <property type="entry name" value="39S ribosomal protein L43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039927">
        <property type="entry name" value="Ribosomal_mL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007741">
        <property type="entry name" value="Ribosomal_mL43/mS25/NADH_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21396">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21396:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05047">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein/NADH dehydrogenase" evidence="7">
        <location>
            <begin position="36"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="JAV93583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0801845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="184" mass="21374" checksum="46F70FE284436471" modified="2017-08-30" version="1">MSNKLFLTPKFITTPSQNGVGRYVCQLQRVVLKFCKNHGSSRGLREFIEHDLINYSKENPGTVVYLKPRRHRGPVIVGEYLNGDQQSIYCRNFSREEISKWLNLLLSQSGNHDGTRLRKLWHTEHPSIQGPWTPYTFRDPMLNLVKFPNADLSKVLNQPKTATEQLLELFEKKKNDHAPKQQSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1N7I5</accession>
    <name>A0A1Y1N7I5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PPYR_07575</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">1611_PpyrPB1</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">1611_PpyrPB1</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01011814">
        <property type="protein sequence ID" value="JAV93428.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1N7I5"/>
    <dbReference type="InParanoid" id="A0A1Y1N7I5"/>
    <dbReference type="OrthoDB" id="1095242at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048598">
        <property type="term" value="P:embryonic morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
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        <property type="entry name" value="Zinc finger 45-like"/>
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    </dbReference>
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    </dbReference>
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            <end position="218"/>
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        </location>
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    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="288"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
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            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="344"/>
            <end position="371"/>
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        <location>
            <begin position="372"/>
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        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="400"/>
            <end position="428"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022723"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
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        <source>
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            <dbReference type="ARBA" id="ARBA00023015"/>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
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        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="JAV93428.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAB0799695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="452" mass="53104" checksum="FF758C285AF17A53" modified="2017-08-30" version="1">MDLCTADTISLKEEQKLFTIDEADIKKEVIEPPPQEVVEVEPKVSVKEECLTNNSYLPQMKTEPNLVLNTKEENTPMLPKYDPLKCGICSSSFETETHLSDHVQEPAQKRTFECCGCRKRFRDMTQLNVHYRKHTGEKPYSCDTCGKQFSINGNLSKHMRTHTGERRFSCEVCERKFTQYAHLEDHMKTHSLDRPFLCEQCDGSFKTKSRLRKHIKSHDQTVKRKNVGCQICFRTFWSAKQLMVHMSRRHTKTDLPFQCIVCDKKFKEYQNYQSHMRVHRKHPIMRTYKCHMCEKCFASSSHLSRHINSHAGIKPYICQLCMRAFPCSQNLKRHMMTHTGEKPFTCETCQKSFLTLENLNRHTRVHTGEKPYECPTCGRHFAHSTTVKEHMRLHTGEKPFGCSVCNKRFGMNKLLYRHIRKQHPEEAGLIIKKENHRSFHYVDIKSEPIKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1NC19</accession>
    <name>A0A1Y1NC19_PHOPY</name>
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        <recommendedName>
            <fullName evidence="2">PSP proline-rich domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="4" type="ORF">PPYR_10200</name>
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    <organism evidence="3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
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        <property type="protein sequence ID" value="JAV95494.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KAB0796139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="10260794at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:U12-type spliceosomal complex"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="DUF382"/>
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    </dbReference>
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        <property type="entry name" value="U2_snRNP_Complex_Component"/>
    </dbReference>
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        <property type="entry name" value="SPLICING FACTOR 3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12785:SF6">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DUF382"/>
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    </dbReference>
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    </dbReference>
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            <end position="482"/>
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            <begin position="1"/>
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        </location>
    </feature>
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            <end position="550"/>
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        </location>
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            <end position="727"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="JAV95494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0796139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="727" mass="81345" checksum="DB58A4203067A5D0" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1NC86</accession>
    <name>A0A1Y1NC86_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Striatin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PPYR_07785</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat striatin family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01006997">
        <property type="protein sequence ID" value="JAV95493.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1NC86"/>
    <dbReference type="FunCoup" id="A0A1Y1NC86">
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        <source>
            <dbReference type="Pfam" id="PF08232"/>
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            <dbReference type="EMBL" id="KAB0799905.1"/>
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</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1NCP5</accession>
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            <taxon>Insecta</taxon>
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            <taxon>Neoptera</taxon>
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            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
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    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
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                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
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            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
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    <reference evidence="8" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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    </feature>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF14656"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="JAV95712.1"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAB0795581.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
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    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1289" mass="146121" checksum="A4EABA823045ABC1" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
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        <recommendedName>
            <fullName evidence="4">Nuclear speckle splicing regulatory protein 1 N-terminal domain-containing protein</fullName>
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        <name evidence="6" type="ORF">PPYR_03245</name>
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            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
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            <taxon>Coleoptera</taxon>
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        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
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                <person name="Al-Wathiqui N."/>
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            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
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                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
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        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NSRP1 family.</text>
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    <dbReference type="EMBL" id="GEZM01006624">
        <property type="protein sequence ID" value="JAV95678.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1NDN6"/>
    <dbReference type="FunCoup" id="A0A1Y1NDN6">
        <property type="interactions" value="238"/>
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    <dbReference type="InParanoid" id="A0A1Y1NDN6"/>
    <dbReference type="OrthoDB" id="446635at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    <dbReference type="InterPro" id="IPR018612">
        <property type="entry name" value="NSRP1_N"/>
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    <dbReference type="PANTHER" id="PTHR31938">
        <property type="entry name" value="NUCLEAR SPECKLE SPLICING REGULATORY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31938:SF4">
        <property type="entry name" value="NUCLEAR SPECKLE SPLICING REGULATORY PROTEIN 1"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
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        <location>
            <begin position="55"/>
            <end position="169"/>
        </location>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
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        <location>
            <begin position="99"/>
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        </location>
    </feature>
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        <location>
            <begin position="187"/>
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        </location>
    </feature>
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        <location>
            <begin position="103"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="187"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="249"/>
            <end position="260"/>
        </location>
    </feature>
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        <location>
            <begin position="265"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF09745"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="JAV95678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0791445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="328" mass="38034" checksum="9E2E5073DADEBE1E" modified="2017-08-30" version="1">MEKQYGLIVPNKSKPLHPIGPVRPSIFGNDSDSDSGAAKPTGLKTALKRQDRLLQEKAIEEDPTVFQYDELYDDMDAKRKESKLSRKDLDKKPKYINKLLQSAERRKRENERRIERQVQREREAEGEEFKDKDSFVTSAYRAKLEELKKLDEEEEREDYLEAIGDVRKQGNIDGFYRHLYDQKVLYEDKVEEGEGAKSKRRRYRSQREQSSDSEPEVKPQLQHLPSNIDADSDFSIDSSDSEGEKGRAEAVPPVEAATETSAEVVRTDENKTEAEEVEEVKVEAKVREKVKVDIWKKRTVGDVFDSALRRYFERKALRESGSYVRPIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1NG92</accession>
    <name>A0A1Y1NG92_PHOPY</name>
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        <recommendedName>
            <fullName evidence="3">Zinc finger protein 830</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Coiled-coil domain-containing protein 16</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PPYR_04004</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">1611_PpyrPB1</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">1611_PpyrPB1</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Transcribed_RNA"/>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ZNF830-like"/>
    </dbReference>
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        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
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        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13278">
        <property type="entry name" value="ZINC FINGER PROTEIN 830"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13278:SF0">
        <property type="entry name" value="ZINC FINGER PROTEIN 830"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="6" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger double-stranded RNA binding" evidence="15">
        <location>
            <begin position="65"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="ZNF380 coiled-coil" evidence="16">
        <location>
            <begin position="184"/>
            <end position="262"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF23406"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="JAV96558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAB0801818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="302" mass="35007" checksum="1517238BD9C53E0F" modified="2017-08-30" version="1">MSAAFKNAKKKLPQSELRRIMNDHKIKKTTKIESPLAKYPFLLIVIRLPSLYFFLTLNKYNDLGQLTCVLCQSIVRSEGVWNVHINSKQHRDKVEEARRLKETTNNFTTNPKRSLEVPIEVPTKKIKGILKNSKTSTHDNDASNTEISSNVGNAVTFKEVSVDPVSNKQDEQMVIDPKDDQSAIPEGFFDDPKQDAKVRHIDYKDPVEEEWERFQKAIRDANNESANIIAEDHEEATNERQIDEIDEQMKNWSKVLTLEKRKLELTTTTNTFENMDADLSEDSADDVEFEEYVDWRTKKFLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1NGB1</accession>
    <name>A0A1Y1NGB1_PHOPY</name>
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        <recommendedName>
            <fullName evidence="5">G-protein coupled receptors family 2 profile 2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_11196</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
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        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
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            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01007507">
        <property type="protein sequence ID" value="JAV95136.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0794357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1NGB1"/>
    <dbReference type="InParanoid" id="A0A1Y1NGB1"/>
    <dbReference type="OrthoDB" id="10069455at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035240">
        <property type="term" value="F:dopamine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072544">
        <property type="term" value="F:L-DOPA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035643">
        <property type="term" value="F:L-DOPA receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072545">
        <property type="term" value="F:L-tyrosine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032438">
        <property type="term" value="P:melanosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050848">
        <property type="term" value="P:regulation of calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001414">
        <property type="entry name" value="GPR143"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15177">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15177:SF2">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02101">
        <property type="entry name" value="Ocular_alb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00965">
        <property type="entry name" value="OCULARALBNSM"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="JAV95136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0794357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="361" mass="41586" checksum="48521C0C0B332CA8" modified="2017-08-30" version="1">MADPTIQTFCCYNTNGNNSPWKTENTLLVATEFNSATYNAICLFSSTLGILGAIYQILPRREFSRHHRWISFSAERGRKIILWLAVTDLLASLGVLIRACLWLNFKDIMPAIDGSHSVIFCALSSAWIQYFYTSTWVWTLCYAIDMRLILNEKAERIKLYHTAAWIIPAVLTAIGLSLLYYPDANCRASLSKKEAMLRILPNYIVTYIPIAIIMIASPCLYLFSCKDMEKIIMCSSGQFTRSEREVIGAIRIKFAVINIVFYVCWFPNLLNAFLLWTLWFQLPVTLVIVTWYIMAFTNPLQAFFNCLVYRRWNTGSEEVVLPWGRSKSSGIYNTTRTTDSQEDLPLLHNFQRNNSHLYVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N3ZYN0</accession>
    <name>A0A5N3ZYN0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PPYR_15513</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01001797">
        <property type="protein sequence ID" value="KAB0790159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N3ZYN0"/>
    <dbReference type="FunCoup" id="A0A5N3ZYN0">
        <property type="interactions" value="110"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N3ZYN0"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000176">
        <property type="entry name" value="pancreas/duodenum homeobox protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001827">
        <property type="entry name" value="Homeobox_Antennapedia_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050848">
        <property type="entry name" value="Homeobox_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24333">
        <property type="entry name" value="HOMEO BOX HB9 LIKE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24333:SF13">
        <property type="entry name" value="HOMEOBOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00032">
        <property type="entry name" value="ANTENNAPEDIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="9">
        <location>
            <begin position="137"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="139"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="192"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="251"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="689"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="262"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="311"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="324"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0790159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="726" mass="79910" checksum="BA9AB766CB90E219" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N3ZZP0</accession>
    <name>A0A5N3ZZP0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DDE-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_15068</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01001149">
        <property type="protein sequence ID" value="KAB0790535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N3ZZP0"/>
    <dbReference type="InParanoid" id="A0A5N3ZZP0"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF71">
        <property type="entry name" value="ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE-1" evidence="1">
        <location>
            <begin position="39"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0790535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="383" mass="42856" checksum="85CBDDBE90A13751" modified="2020-02-26" version="1" fragment="single">MDESGLSTVPSKNSKIIACKGKKQVGVLTSAERGQHLTVVCSFSAAGVYVPPAFIFPRKNMKKELMDNAPAGAVAFTQEHGWMDKNIFVKWLNHFVKHVKPTKEDKVLLMLDGHISHKSLEAQEYAKANGIILFCFPPHCTHRVQPLYVVFFGPLSTYYNQELNLWLKTHPGRTVTHYQVAELFKNAYQKAATLSNAENGFSTTGIYPFQPDIFPDWMFAPAEATDVEQENVGLPESNFANKEPEALLADATQKDISFENTGPSTSIQKPLSSCCSVAITDISPLPKATSLHRKKRSGKTGKSGVLNSTPEIAALKEIVAQKEEAKRRKSARKTKRVLNLHEYKEIQKDAQEEEEFPVEDTDDEDDAVCIYCNELYSQSRRNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A1B5</accession>
    <name>A0A5N4A1B5_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_02889</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A1B5"/>
    <dbReference type="InParanoid" id="A0A5N4A1B5"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001164">
        <property type="entry name" value="GH01279p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050328">
        <property type="entry name" value="Dev_Immune_Receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373:SF370">
        <property type="entry name" value="FISH-LIPS, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373">
        <property type="entry name" value="SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0791089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="387" mass="43099" checksum="2E9495588A359627" modified="2020-02-26" version="1">MDSALKNRNVELFGSLLCCQGIHSAESFKEAIAETSAKKIEELRLQDSTIEYLAPSWFAEFSALTKLSITSSAVKTIPSSAFAIPSDLQELHVDNCAIAHIDNEGFSGLCQLKRLLFTNCTSYPLRLHGLTSLEILDLSSNSIDRIEPGTFDHLDRLRVLILSRNKLIHIPKLIFEHLTSLHLDRNHIESLDPEVFLGLPHLEVLRLENNSLVELHRELLNPLLSLASLNLSGNSLRYLHQGTFAQLLNLSDLNLSNNELTSIPKGLFDNLPRLTSLDLAFNQIKQLETDTFGCIPRLESVNLEGNRLRQLPAAIFSGSPAMTRLDLNSNQIEAINRGAFQELSNLDELFLNKNRISHIEVGAFQGLGLSSIDLGENCLHSIHLACR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A415</accession>
    <name>A0A5N4A415_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Coatomer subunit delta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PPYR_14024</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 10">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10 11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10 11">Cytoplasmic vesicle</location>
            <location evidence="10 11">COPI-coated vesicle membrane</location>
            <topology evidence="10 11">Peripheral membrane protein</topology>
            <orientation evidence="10 11">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10 11">Golgi apparatus membrane</location>
            <topology evidence="10 11">Peripheral membrane protein</topology>
            <orientation evidence="10 11">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the adaptor complexes medium subunit family. Delta-COP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A415"/>
    <dbReference type="FunCoup" id="A0A5N4A415">
        <property type="interactions" value="1790"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A415"/>
    <dbReference type="OrthoDB" id="10266042at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051645">
        <property type="term" value="P:Golgi localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09254">
        <property type="entry name" value="AP_delta-COPI_MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14830">
        <property type="entry name" value="Delta_COP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1170:FF:000007">
        <property type="entry name" value="Coatomer subunit delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000003">
        <property type="entry name" value="Coatomer subunit delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027059">
        <property type="entry name" value="Coatomer_dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10121">
        <property type="entry name" value="COATOMER SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10121:SF0">
        <property type="entry name" value="COATOMER SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5 10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="13">
        <location>
            <begin position="271"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="148"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAB0792063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="512" mass="57168" checksum="8EC253827EF26659" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A467</accession>
    <name>A0A5N4A467_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_06505</name>
        <name evidence="2" type="ORF">PPYR_14074</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000004">
        <property type="protein sequence ID" value="KAB0800766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A467"/>
    <dbReference type="InParanoid" id="A0A5N4A467"/>
    <dbReference type="OrthoDB" id="6781892at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34239">
        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34239:SF2">
        <property type="entry name" value="TRANSPOSABLE ELEMENT P TRANSPOSASE_THAP9 CONSERVED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="393"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0792113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0800766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="443" mass="50573" checksum="97BB8E9F878E019D" modified="2020-02-26" version="1">MGKHKRDRSRSRSSTKRSFNKEIRDLKRKLDKLEKERDRAKRDFSRFRESCSRNETISRGNRECRSPSESDSSRRRRRRSRSQRRSPSETSLNPGRDTQGRREGRSSSKATSTKLPFRREQESRSPSVALSLFTRTDTSRAANSATIDFVGPGGRHSSSAALVASSADFSPRKEESPALILLDDAGISEEIRLILGPDPNQQKKSTFNLHKAVEPIWTHILGFGLPKEECDELFKKYELPINCKFLTPPRINPEVEANLNTLHSTRDQTHSQYQFRLSKALAALGISLNVILEEEENIPRASKDRILSSIADSGRLLCSLFNDISLKRRQLILPLMNKHIKTLVEQIPPGDFLFGPDLGDKIQAIKTMEKVGKEIRVPQPLYNRYQQNSVAFQKKKGGGAEKSHTATSGQLNRRRPTYRKREVRSQRGRLSMPQKSSIHQKYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A508</accession>
    <name>A0A5N4A508_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small-subunit processome Utp12 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_14340</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UTP5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A508"/>
    <dbReference type="FunCoup" id="A0A5N4A508">
        <property type="interactions" value="1955"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A508"/>
    <dbReference type="OrthoDB" id="30195at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007148">
        <property type="entry name" value="SSU_processome_Utp12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052414">
        <property type="entry name" value="U3_snoRNA-assoc_WDR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44267">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44267:SF1">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04003">
        <property type="entry name" value="Utp12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="Small-subunit processome Utp12" evidence="6">
        <location>
            <begin position="422"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="552"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="565"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0792381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="590" mass="65007" checksum="711DC7942206807A" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A558</accession>
    <name>A0A5N4A558_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Protein-lysine N-methyltransferase SMYD4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">SET and MYND domain-containing protein 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PPYR_14401</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">1611_PpyrPB1</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Protein-lysine N-methyltransferase. Monomethylates PRMT5, modulating its transcriptional activity. May also act as a histone methyltransferase. Plays a critical role in cardiac development. Acts as a key epigenetic regulator of gene expression during cardiac development via its dual activities as a methyltransferase and negative regulator of HDAC1.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-lysyl-[protein] + S-adenosyl-L-methionine = N(6)-methyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51736"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:13053"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61929"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A558"/>
    <dbReference type="FunCoup" id="A0A5N4A558">
        <property type="interactions" value="270"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A558"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042826">
        <property type="term" value="F:histone deacetylase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10536">
        <property type="entry name" value="SET_SMYD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052097">
        <property type="entry name" value="SET-MYND_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044421">
        <property type="entry name" value="SMYD4_SET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46165">
        <property type="entry name" value="SET AND MYND DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46165:SF2">
        <property type="entry name" value="SET AND MYND DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SET" evidence="16">
        <location>
            <begin position="199"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="MYND-type" evidence="17">
        <location>
            <begin position="248"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00093423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00093635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00093680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAB0792442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="505" mass="57535" checksum="8E192BF01C723156" modified="2020-02-26" version="1">MDGLFEKYTGITIKGAEDNVAEIFSQFYAIDQHAKLWLRTLLQSSQLKDDTKSIALRLEGNKYYAEKNFRKAFRCYTKALCFARNDLGFITANRSALFYMTGHYEDCLSDIAFAFKHDLPDHIKLKLLIRRIKCLAILHLDVKNAVDEAVDFTSTREDKVKEEILKASLSKGSTEPKPAAKVPSLKDAEINCNFLSASSAVSLRYDEIRGRHVVANKRLKPGDILFVEKPFVFAPVFNDDKELSLTRCYNCLKLIYSSIPCQTCVVCVFCNEECRESSWQEFHQWECCGMRADLWYHLGIGFPAVRALFKGLPHGLRALSSSYEDTAKFGDPFDNYPYFDKLISNLSKMDNILPLIVTACVIVLYLEDYTGYLKGMSKQTEFVCSLGGRLVKHMAQLQCNSSLICTKLNTDKFFASEDSSLACGIYPSVSMMNHSCKSNITIDYFDQVLVAKAAEEVYPGEEISNCYGIDYRYADKETRQEHCNQLYFFTCNCRICKHPELELPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A7Q7</accession>
    <name>A0A5N4A7Q7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">TAP-C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PPYR_12949</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NXF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A7Q7"/>
    <dbReference type="FunCoup" id="A0A5N4A7Q7">
        <property type="interactions" value="1026"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A7Q7"/>
    <dbReference type="OrthoDB" id="25872at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14342">
        <property type="entry name" value="UBA_TAP-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000018">
        <property type="entry name" value="Nuclear RNA export factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.50:FF:000004">
        <property type="entry name" value="Nuclear RNA export factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000384">
        <property type="entry name" value="Nuclear RNA export factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002075">
        <property type="entry name" value="NTF2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018222">
        <property type="entry name" value="Nuclear_transport_factor_2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057125">
        <property type="entry name" value="NXF1/2/3/5-like_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030217">
        <property type="entry name" value="NXF_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005637">
        <property type="entry name" value="TAP_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015245">
        <property type="entry name" value="Tap_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10662">
        <property type="entry name" value="NUCLEAR RNA EXPORT FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10662:SF22">
        <property type="entry name" value="NUCLEAR RNA EXPORT FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24048">
        <property type="entry name" value="LRR_NXF1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22602">
        <property type="entry name" value="NXF_NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09162">
        <property type="entry name" value="Tap-RNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03943">
        <property type="entry name" value="TAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00804">
        <property type="entry name" value="TAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50177">
        <property type="entry name" value="NTF2_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51281">
        <property type="entry name" value="TAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NTF2" evidence="10">
        <location>
            <begin position="366"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="TAP-C" evidence="11">
        <location>
            <begin position="563"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAB0793329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="617" mass="70079" checksum="5CAB533980C281B2" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A9M1</accession>
    <name>A0A5N4A9M1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pupal cuticle protein C1B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_13642</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0794022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A9M1"/>
    <dbReference type="InParanoid" id="A0A5N4A9M1"/>
    <dbReference type="OrthoDB" id="6630852at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022727">
        <property type="entry name" value="Cuticle_C1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39068">
        <property type="entry name" value="LARVAL/PUPAL CUTICLE PROTEIN H1C-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39068:SF5">
        <property type="entry name" value="PUPAL CUTICLE PROTEIN C1B-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11018">
        <property type="entry name" value="Cuticle_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0193">Cuticle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024438447" description="Pupal cuticle protein C1B" evidence="3">
        <location>
            <begin position="19"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0794022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="248" mass="25170" checksum="DD98ACCB811928FC" modified="2020-02-26" version="1">MAFKFIVLCAALIVGTQAGGLLSPATYAPGPAIGVAYSAAPAVSHFTYSSPLVSYGTPYAAAAPAITSQSSNILRTYGNLGQISTYSKTIDTPFSSVQKSDVRVSNPGLKIAAAPALAYAAAPVAYAAAPAAISYSAAPAVSHFSYSSPIVSYGTPYTAAHAPAITSQSSNILRSYGNLGQISTYSKTIDTPFSSVQKSDVRVSNPGLKIAAAPALAYAAAPAAVTYSAAPAVSHFTYAGSYGLNYGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A9N8</accession>
    <name>A0A5N4A9N8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cyclic nucleotide-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PPYR_13588</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A9N8"/>
    <dbReference type="InParanoid" id="A0A5N4A9N8"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015386">
        <property type="term" value="F:potassium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051453">
        <property type="term" value="P:regulation of intracellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098719">
        <property type="term" value="P:sodium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018422">
        <property type="entry name" value="Cation/H_exchanger_CPA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110">
        <property type="entry name" value="SODIUM/HYDROGEN EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110:SF86">
        <property type="entry name" value="SODIUM_HYDROGEN EXCHANGER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0915">Sodium</keyword>
    <keyword evidence="9" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="186"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="260"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="294"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="522"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="552"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="595"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="12">
        <location>
            <begin position="804"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1137"/>
            <end position="1157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAB0793968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1157" mass="132268" checksum="B3B2AEF25EF98536" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A9Y4</accession>
    <name>A0A5N4A9Y4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="6">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PPYR_13755</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0794135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A9Y4"/>
    <dbReference type="InParanoid" id="A0A5N4A9Y4"/>
    <dbReference type="OrthoDB" id="19653at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000155">
        <property type="entry name" value="Carboxylic ester hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142:SF1">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024503394" description="Carboxylic ester hydrolase" evidence="6">
        <location>
            <begin position="17"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="7">
        <location>
            <begin position="22"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0794135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="546" mass="61393" checksum="BEE9105ECF087C23" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AA70</accession>
    <name>A0A5N4AA70_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_13768</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0794148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AA70"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511">
        <property type="entry name" value="PROTEIN CBG23764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511:SF12">
        <property type="entry name" value="RHO TERMINATION FACTOR N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="His-Me finger endonucleases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="1346"/>
            <end position="1367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0794148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1809" mass="208936" checksum="27A1543352D2142E" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AAA2</accession>
    <name>A0A5N4AAA2_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Gamma-interferon-inducible lysosomal thiol reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PPYR_13872</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GILT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0794252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AAA2"/>
    <dbReference type="InParanoid" id="A0A5N4AAA2"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016671">
        <property type="term" value="F:oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004911">
        <property type="entry name" value="Interferon-induced_GILT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13234">
        <property type="entry name" value="GAMMA-INTERFERON INDUCIBLE LYSOSOMAL THIOL REDUCTASE GILT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13234:SF8">
        <property type="entry name" value="GAMMA-INTERFERON-INDUCIBLE LYSOSOMAL THIOL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03227">
        <property type="entry name" value="GILT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0794252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="217" mass="24048" checksum="228DB876D356BCAE" modified="2020-02-26" version="1">MWFDFPVPIIWEKQIIEIESCQNSLFLLQVSSEKLQVSIYYEALCSDSVQFITKQLQPAYKLIGSNLEVDLVPYGKASQTQENGKWFFRCQHGPPECHGNILQACGLATDKSQAQKVDFVYCVMNQWDPSSDDAIEKCSGKLGLTSDAIFQCANSGEGEILLAKNGVQTHAVTPKITFIPTIVFNGVYSSANQNGAFSNFLKTACDQFHDKPKGCNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AAU6</accession>
    <name>A0A5N4AAU6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">VPS9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PPYR_11217</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0794378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AAU6"/>
    <dbReference type="FunCoup" id="A0A5N4AAU6">
        <property type="interactions" value="747"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AAU6"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.80">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041545">
        <property type="entry name" value="DUF5601"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003123">
        <property type="entry name" value="VPS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045046">
        <property type="entry name" value="Vps9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037191">
        <property type="entry name" value="VPS9_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002653">
        <property type="entry name" value="Znf_A20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101">
        <property type="entry name" value="RAB GDP/GTP EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101:SF122">
        <property type="entry name" value="RABAPTIN-5-ASSOCIATED EXCHANGE FACTOR FOR RAB5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18151">
        <property type="entry name" value="DUF5601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02204">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01754">
        <property type="entry name" value="zf-A20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00167">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00259">
        <property type="entry name" value="ZnF_A20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109993">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51205">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51036">
        <property type="entry name" value="ZF_A20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="A20-type" evidence="4">
        <location>
            <begin position="13"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="VPS9" evidence="5">
        <location>
            <begin position="216"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0794378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="592" mass="66754" checksum="50010EB2F061827A" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AB96</accession>
    <name>A0A5N4AB96_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PPYR_11420</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">1611_PpyrPB1</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0794581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AB96"/>
    <dbReference type="InParanoid" id="A0A5N4AB96"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11056">
        <property type="entry name" value="CYP6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000042">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050476">
        <property type="entry name" value="Insect_CytP450_Detox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292:SF45">
        <property type="entry name" value="CYTOCHROME P450 6G1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0492">Microsome</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="435"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAB0794581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="489" mass="55494" checksum="21275C2D716E6B9E" modified="2020-02-26" version="1">MAIILATLAAVFAGIVIPLYLYCKHKFNYWKSRGVPNKKPTFLFGNALSVAFSPDPISLYISKLCGKFGSSPYFGFYSFTRPYLILKDPDIIKHILVKDFDAFPNRLEDAPWEPILSNTLFAIRTPNWKELRAQMSPVFSSAKMRSMMSLIMECGKNMEQYITMKVGENVEVKEVCSKFMTDVISSCAFGINTNSFKHEKNELKKHAEMILPNTIIGCLKMAAYFFAPTAVRLLKFPLFNKESVKFFKCIYATVIKQRAQNNAGRKDLVDILSKNPYFCHESNDMLIANPLVFFIAGLEPTSIAIALTLHELGVNPNIQRKLRAEIASVTGRCDGLTFEAVNEMKYLHMVISETLRKYPMTVMIPRQAVEDYKIKKTGLIIEKGTQIIISHDALHKDPKYFPNPEVFDPERFSESNVHSLNSYTYLPFGKGSRNCIGERFALLTAKVGIIYALTKFMVHTNSNTTDPMEFSRSLFLTAKHGVNLTFTRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ACB5</accession>
    <name>A0A5N4ACB5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Single domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_11804</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0794965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ACB5"/>
    <dbReference type="FunCoup" id="A0A5N4ACB5">
        <property type="interactions" value="61"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4ACB5"/>
    <dbReference type="OrthoDB" id="6744323at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029277">
        <property type="entry name" value="SVWC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053308">
        <property type="entry name" value="Vago-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39957">
        <property type="entry name" value="AT09846P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39957:SF1">
        <property type="entry name" value="AT09846P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15430">
        <property type="entry name" value="SVWC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01318">
        <property type="entry name" value="SVWC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024373413" description="Single domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="Single" evidence="4">
        <location>
            <begin position="33"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0794965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="100" mass="10525" checksum="279DB84A664BBC00" modified="2020-02-26" version="1">MKMQIALVLSFALFSAALGWTSREQVEVDPEKCVSSDPNVGTLKVGISTLPDSCVRATCRPGMIDLAGCGVGSVGKPCYMSGEDLSKPYPECCPRPVCPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ACS6</accession>
    <name>A0A5N4ACS6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UDP-glucuronosyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PPYR_11951</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:132367"/>
            <dbReference type="ChEBI" id="CHEBI:132368"/>
            <dbReference type="EC" id="2.4.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Membrane</location>
            <topology evidence="5">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.17" evidence="5"/>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0795112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ACS6"/>
    <dbReference type="FunCoup" id="A0A5N4ACS6">
        <property type="interactions" value="429"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4ACS6"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015020">
        <property type="term" value="F:glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000050">
        <property type="entry name" value="UDP-glucuronosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035595">
        <property type="entry name" value="UDP_glycos_trans_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF159">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00375">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="473"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0795112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="521" mass="58985" checksum="95720830DC61B07F" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AD18</accession>
    <name>A0A5N4AD18_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">DNA ligase</fullName>
            <ecNumber evidence="19">6.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">PPYR_12055</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">1611_PpyrPB1</strain>
            <tissue evidence="25">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18 19">
            <text>ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + diphosphate.</text>
            <dbReference type="EC" id="6.5.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 20">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="19"/>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0795216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AD18"/>
    <dbReference type="FunCoup" id="A0A5N4AD18">
        <property type="interactions" value="1378"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AD18"/>
    <dbReference type="OrthoDB" id="206088at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070421">
        <property type="term" value="C:DNA ligase III-XRCC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006273">
        <property type="term" value="P:lagging strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07902">
        <property type="entry name" value="Adenylation_DNA_ligase_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07967">
        <property type="entry name" value="OBF_DNA_ligase_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3260.10:FF:000002">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000085">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.30:FF:000003">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3260.10">
        <property type="entry name" value="DNA ligase, ATP-dependent, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1740.10">
        <property type="entry name" value="Zinc finger, PARP-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050191">
        <property type="entry name" value="ATP-dep_DNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000977">
        <property type="entry name" value="DNA_ligase_ATP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016059">
        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012308">
        <property type="entry name" value="DNA_ligase_ATP-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031916">
        <property type="entry name" value="LIG3_BRCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001510">
        <property type="entry name" value="Znf_PARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036957">
        <property type="entry name" value="Znf_PARP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00574">
        <property type="entry name" value="dnl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674">
        <property type="entry name" value="DNA LIGASE 1/3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674:SF9">
        <property type="entry name" value="DNA LIGASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04675">
        <property type="entry name" value="DNA_ligase_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16759">
        <property type="entry name" value="LIG3_BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00645">
        <property type="entry name" value="zf-PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01336">
        <property type="entry name" value="zf-PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117018">
        <property type="entry name" value="ATP-dependent DNA ligase DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00697">
        <property type="entry name" value="DNA_LIGASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00333">
        <property type="entry name" value="DNA_LIGASE_A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50064">
        <property type="entry name" value="ZF_PARP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="17" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="9 19" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14 19" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="15 19" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4 19" id="KW-0436">Ligase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PARP-type" evidence="22">
        <location>
            <begin position="13"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-dependent DNA ligase family profile" evidence="23">
        <location>
            <begin position="479"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="24">
        <location>
            <begin position="798"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="107"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="735"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="133"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="144"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="746"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="767"/>
            <end position="785"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00034003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU000617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="KAB0795216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="893" mass="101159" checksum="BC94A3A7377823A1" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AF28</accession>
    <name>A0A5N4AF28_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Peptidase M13 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PPYR_09998</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0795937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AF28"/>
    <dbReference type="FunCoup" id="A0A5N4AF28">
        <property type="interactions" value="79"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AF28"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08662">
        <property type="entry name" value="M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF228">
        <property type="entry name" value="PROTEIN GONE EARLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="10">
        <location>
            <begin position="6"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="9">
        <location>
            <begin position="369"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0795937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="568" mass="64802" checksum="26679DF0276B3C25" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AFE9</accession>
    <name>A0A5N4AFE9_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_10116</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AFE9"/>
    <dbReference type="InParanoid" id="A0A5N4AFE9"/>
    <dbReference type="OrthoDB" id="6777429at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0796055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="348" mass="40747" checksum="39C311C5972CE26D" modified="2020-02-26" version="1">MSGNDIDEEIQWGLHYRQDKKRNVKGFVVPKKSPLNVKDLWQRYQVTKNIQDLQSIKKRASIKIPPNSFRTPPKNKVGLLSRATFTRRQYFNYLATPSTFRVDEEPDPITVLKKKLRPKKCSARLVELARPRKVRVYGTWTDFWPQLSGEAIERLGGLLQTDRTLDPTFARCCFSDMDRKRKKENRKQKRKQKKTRKRRKREDVKWIKLQTSTTADLLVSFLRDSVPKDISYKQMLLSDTILEQLKERQHLKSKPLRNSKNVYQRSIYEIVDQIALWIDNVARYVDAQYTDSVEEITNKTSFETSSALDEEQEEEGSTVQRFVLPPIPSFPNSPVSNFASPFESGIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AFS0</accession>
    <name>A0A5N4AFS0_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_10222</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AFS0"/>
    <dbReference type="InParanoid" id="A0A5N4AFS0"/>
    <dbReference type="OrthoDB" id="5917530at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0796161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="198" mass="21772" checksum="01E9FDD43E98D333" modified="2020-02-26" version="1">MVPGAERKLREHQRLSTEYLVKHAGTSHRQQYDPICTDRPKYECECGPLLNKTPPDVCTMNKSMEFISSDISTTPGITEPNYTGVSNTLAAQTVPIQIKNHCTTTLHTTPFSYSNFSCNKYGTMPHSGVTVHQGFLGVAEIGSSSSNSSSSYCSKSKTLQHQRPKKKCVKIETFQTPDAGFVDFTKRSSTFGYSGSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AGB8</accession>
    <name>A0A5N4AGB8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13 16">Amidophosphoribosyltransferase</fullName>
            <shortName evidence="16">ATase</shortName>
            <ecNumber evidence="3 16">2.4.2.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14 16">Glutamine phosphoribosylpyrophosphate amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">PPYR_10414</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">1611_PpyrPB1</strain>
            <tissue evidence="21">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>5-phospho-beta-D-ribosylamine + L-glutamate + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + L-glutamine + H2O</text>
            <dbReference type="Rhea" id="RHEA:14905"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58681"/>
            <dbReference type="EC" id="2.4.2.14"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="15">
            <dbReference type="Rhea" id="RHEA:14907"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="18">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="19">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="19">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 16">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.14" evidence="3 16"/>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AGB8"/>
    <dbReference type="FunCoup" id="A0A5N4AGB8">
        <property type="interactions" value="1397"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AGB8"/>
    <dbReference type="OrthoDB" id="191723at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00124"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004044">
        <property type="term" value="F:amidophosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00715">
        <property type="entry name" value="GPATase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000047">
        <property type="entry name" value="Amidophosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01931">
        <property type="entry name" value="PurF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005854">
        <property type="entry name" value="PurF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035584">
        <property type="entry name" value="PurF_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01134">
        <property type="entry name" value="purF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11907">
        <property type="entry name" value="AMIDOPHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13522">
        <property type="entry name" value="GATase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000485">
        <property type="entry name" value="Amd_phspho_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="5 16" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 19" id="KW-0408">Iron</keyword>
    <keyword evidence="12 19" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 18" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 16" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="20">
        <location>
            <begin position="26"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="17">
        <location>
            <position position="26"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="403"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="404"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="440"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="498"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="501"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00033770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00033776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAB0796353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="516" mass="56299" checksum="CB68DBE8B480C9B6" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AGZ5</accession>
    <name>A0A5N4AGZ5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Anticodon-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_10648</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AGZ5"/>
    <dbReference type="FunCoup" id="A0A5N4AGZ5">
        <property type="interactions" value="84"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AGZ5"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030956">
        <property type="term" value="C:glutamyl-tRNA(Gln) amidotransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070681">
        <property type="term" value="P:glutaminyl-tRNAGln biosynthesis via transamidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036113">
        <property type="entry name" value="Asp/Glu-ADT_sf_sub_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003837">
        <property type="entry name" value="GatC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15004">
        <property type="entry name" value="GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT C, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15004:SF0">
        <property type="entry name" value="GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT C, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02686">
        <property type="entry name" value="GatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141000">
        <property type="entry name" value="Glu-tRNAGln amidotransferase C subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Anticodon-binding" evidence="3">
        <location>
            <begin position="394"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0796587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="482" mass="55385" checksum="EFDB546506332984" modified="2020-02-26" version="1">MFRQRLIYKTVINKCNCKFLCSPVKSPSPLAGKPSKKRFLPLKPVQSKIDVNKLPPHTKIDANTIAHLERLSLVDCANKEGIKSLEDAIAFADQILQVDTTGVQPLVTVLEDRPLEVREDVVTDGGCLNEVLSHGQICYTKTMLKKVLELCEVRGFLKSFKDGLKLVGPVGALLRRNLETEWFYNLVINRETSVFMNEGSFVDTYEFARRVCQERSPFGVAEVVKDTEDLFDLDGHFFHKPRYLLTTVFVPPSLSTQFFHDWQRLRRTWWRKLSAYPGRYAFSDLQTNGDSQLLQIRAEYESEKVLVESLRFNQEPHPLLTPEQLFVRDGRKKVQAHYISSNISLDNMLLNCIWDAYDEPDFIGKPRPLLRFHRKLAPYKISFAISATKSSTLEELSSLALYLCRKLRDGHVSCLLLPMTIKTTLESQWAPYDEMGVPYTVILNETTLKNGISLLRSRDTTLKEQVHVTKLPAYVEQLFKNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AI98</accession>
    <name>A0A5N4AI98_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Retrotransposon Copia-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_08079</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AI98"/>
    <dbReference type="InParanoid" id="A0A5N4AI98"/>
    <dbReference type="OrthoDB" id="6779775at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47481">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47481:SF7">
        <property type="entry name" value="CCHC-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0797085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="204" mass="23469" checksum="9611CCD7A96E5377" modified="2020-02-26" version="1">MESDRVNIEKLEGGSNWLTWKFQMRQVLEASELFDVVDGTDSPPSIRDENYRTDIVAWKKNDAKARRAISTACKKQPLLQIMNCDTANSMWTTLKSTYEQTSKSNVLFLQQKYYSFTKEPGDDIATCISKLMEIVQQLKDQKENISDTMVMTKILMALPAEYNHFHSAWESTSAENQTMSNLRARLMAEELRLKSQGQIEHVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AIC2</accession>
    <name>A0A5N4AIC2_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein ECT2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_08086</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AIC2"/>
    <dbReference type="FunCoup" id="A0A5N4AIC2">
        <property type="interactions" value="245"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AIC2"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000281">
        <property type="term" value="P:mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000431">
        <property type="term" value="P:regulation of cytokinesis, actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17733">
        <property type="entry name" value="BRCT_Ect2_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17732">
        <property type="entry name" value="BRCT_Ect2_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01229">
        <property type="entry name" value="PH_Ect2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026817">
        <property type="entry name" value="Ect2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049396">
        <property type="entry name" value="ECT2_BRCT0"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049395">
        <property type="entry name" value="ECT2_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001331">
        <property type="entry name" value="GDS_CDC24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16777">
        <property type="entry name" value="PROTEIN ECT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16777:SF2">
        <property type="entry name" value="PROTEIN ECT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21243">
        <property type="entry name" value="ECT2_BRCT0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21242">
        <property type="entry name" value="ECT2_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12738">
        <property type="entry name" value="PTCB-BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00741">
        <property type="entry name" value="DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="3">
        <location>
            <begin position="128"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="3">
        <location>
            <begin position="218"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="2">
        <location>
            <begin position="401"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="846"/>
            <end position="879"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0797092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="879" mass="99257" checksum="0056D4770638C70C" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AJ37</accession>
    <name>A0A5N4AJ37_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Golgin subfamily A member 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Golgin-97</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PPYR_08356</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">1611_PpyrPB1</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Involved in vesicular trafficking at the Golgi apparatus level. Involved in endosome-to-Golgi trafficking. Mechanistically, captures transport vesicles arriving from endosomes via the protein TBC1D23. Recognized vesicles are then tethered to the trans-Golgi before subsequent SNARE engagement and vesicle fusion. Selectively regulates E-cadherin transport from the trans-Golgi network in tubulovesicular carriers.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Interacts with RAB6A. Directly interacts with TBC1D23. Interacts with FAM91A1; this interaction may be mediated by TBC1D23. Interacts with ARL1; this interaction recruits Golgin-97/GOLGA1 onto the Golgi apparatus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">Secretory vesicle</location>
            <location evidence="2">Acrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AJ37"/>
    <dbReference type="FunCoup" id="A0A5N4AJ37">
        <property type="interactions" value="1451"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AJ37"/>
    <dbReference type="OrthoDB" id="5848685at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001669">
        <property type="term" value="C:acrosomal vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.60:FF:000002">
        <property type="entry name" value="Golgin subfamily A member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.60">
        <property type="entry name" value="GRIP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051952">
        <property type="entry name" value="Golgi-autophagy_related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000237">
        <property type="entry name" value="GRIP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23157:SF24">
        <property type="entry name" value="GOLGIN SUBFAMILY A MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23157">
        <property type="entry name" value="GRIP AND COILED-COIL DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01465">
        <property type="entry name" value="GRIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00755">
        <property type="entry name" value="Grip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50913">
        <property type="entry name" value="GRIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0013">ADP-ribosylation</keyword>
    <keyword evidence="7 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GRIP" evidence="16">
        <location>
            <begin position="572"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="31"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="102"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="314"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00070165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00078935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00093371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00093537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAB0797362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="647" mass="74741" checksum="5C76793680AC9CDD" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AKC5</accession>
    <name>A0A5N4AKC5_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_08754</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AKC5"/>
    <dbReference type="InParanoid" id="A0A5N4AKC5"/>
    <dbReference type="OrthoDB" id="6815232at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062129">
        <property type="term" value="C:chitin-based extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008010">
        <property type="term" value="F:structural constituent of chitin-based larval cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050468">
        <property type="entry name" value="Cuticle_Struct_Prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380">
        <property type="entry name" value="CUTICLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380:SF173">
        <property type="entry name" value="CUTICULAR PROTEIN 47EF, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024425974" evidence="3">
        <location>
            <begin position="17"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0797761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="110" mass="12152" checksum="C34E437B0BFBE368" modified="2020-02-26" version="1">MKAVIFFLPLLGLVIGQSDRPTGEYNRAQDVAAYIVRFSNENDIEKGYKFGFDTSNGISRDEQGTLTNVGTEHEAMEVVGGYQYTDPLQRKVTVTYTAGVNGFVPTITYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AL28</accession>
    <name>A0A5N4AL28_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_09012</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AL28"/>
    <dbReference type="FunCoup" id="A0A5N4AL28">
        <property type="interactions" value="32"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AL28"/>
    <dbReference type="OrthoDB" id="8192957at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051217">
        <property type="entry name" value="Insect_Cuticle_Struc_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236:SF76">
        <property type="entry name" value="ADULT-SPECIFIC CUTICULAR PROTEIN ACP-20-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236">
        <property type="entry name" value="STRUCTURAL CONTITUENT OF CUTICLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00947">
        <property type="entry name" value="CUTICLE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024421255" evidence="3">
        <location>
            <begin position="18"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0798019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="132" mass="13720" checksum="F4AEC75A59BE3F71" modified="2020-02-26" version="1">MYSQIVAFSALVAYASAGLIGGHGYAAAPIAYSHAAPIAVAAHAAPIAVAAHAAPAVDYYAHPKYEFNYGVADAHTGDQKSQHEVRDGDVVKGSYSLHESDGTIRTVHYTADDHNGFNAVVSRSGHALLSNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AL41</accession>
    <name>A0A5N4AL41_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WH2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_09068</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AL41"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003785">
        <property type="term" value="F:actin monomer binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039895">
        <property type="entry name" value="COBL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003124">
        <property type="entry name" value="WH2_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21557">
        <property type="entry name" value="CORDON-BLEU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21557:SF2">
        <property type="entry name" value="CORDON-BLEU PROTEIN-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51082">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WH2" evidence="2">
        <location>
            <begin position="1481"/>
            <end position="1501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="722"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1136"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="243"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="273"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="375"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="730"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1152"/>
            <end position="1173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0798075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1503" mass="167398" checksum="CE6D13474A5480CD" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AM78</accession>
    <name>A0A5N4AM78_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA polymerase</fullName>
            <ecNumber evidence="12">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PPYR_09432</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">1611_PpyrPB1</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="12"/>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A5N4AM78">
        <property type="interactions" value="1626"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AM78"/>
    <dbReference type="OrthoDB" id="6755010at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006273">
        <property type="term" value="P:lagging strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05776">
        <property type="entry name" value="DNA_polB_alpha_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05532">
        <property type="entry name" value="POLBc_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.60:FF:000004">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.690:FF:000003">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3200.20">
        <property type="entry name" value="DNA Polymerase alpha, zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.690">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024647">
        <property type="entry name" value="DNA_pol_a_cat_su_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038256">
        <property type="entry name" value="Pol_alpha_znc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045846">
        <property type="entry name" value="POLBc_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015088">
        <property type="entry name" value="Znf_DNA-dir_DNA_pol_B_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00592">
        <property type="entry name" value="pol2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45861">
        <property type="entry name" value="DNA POLYMERASE ALPHA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45861:SF1">
        <property type="entry name" value="DNA POLYMERASE ALPHA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12254">
        <property type="entry name" value="DNA_pol_alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08996">
        <property type="entry name" value="zf-DNA_Pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00106">
        <property type="entry name" value="DNAPOLB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90234">
        <property type="entry name" value="Zinc finger domain of DNA polymerase-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 12" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 12" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNA polymerase alpha catalytic subunit N-terminal" evidence="17">
        <location>
            <begin position="25"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B exonuclease" evidence="15">
        <location>
            <begin position="453"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B multifunctional" evidence="14">
        <location>
            <begin position="753"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="domain" description="Zinc finger DNA-directed DNA polymerase family B alpha" evidence="16">
        <location>
            <begin position="1224"/>
            <end position="1390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF08996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF12254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAB0798439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1421" mass="162364" checksum="0242BAA04404BA40" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AMI6</accession>
    <name>A0A5N4AMI6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N(6)-L-threonylcarbamoyladenine synthase</fullName>
            <ecNumber evidence="1">2.3.1.234</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PPYR_09517</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-threonylcarbamoyladenylate + adenosine(37) in tRNA = N(6)-L-threonylcarbamoyladenosine(37) in tRNA + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:37059"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.3.1.234"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.234" evidence="1"/>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AMI6"/>
    <dbReference type="FunCoup" id="A0A5N4AMI6">
        <property type="interactions" value="1890"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AMI6"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061711">
        <property type="term" value="F:tRNA N(6)-L-threonylcarbamoyladenine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd24134">
        <property type="entry name" value="ASKHA_NBD_OSGEPL1_QRI7_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017861">
        <property type="entry name" value="KAE1/TsaD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00329">
        <property type="entry name" value="gcp_kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF6">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00789">
        <property type="entry name" value="OSIALOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Gcp-like" evidence="7">
        <location>
            <begin position="5"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0798524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="365" mass="40349" checksum="3554749B26488B47" modified="2020-02-26" version="1">MLTSKMHGGIIPPIAQDLHRKNIENVVADALKEANLSCNEVDAIATTVKPGLPLSLTIGTKYGKHLCRTYNKPFIPIHHMEAHALTARMHDSTIEFPFLVLLISGGHCLLAIAQDVDKFLLMGQSFDDAPGEVFDKMARRLKLKDILEYSEMSGGQAIECAASKATNPLEFNFTPTLLRYRDCNFSFAGNKNQCVRHILAQERKHGLSPDAIIPGVNNLCAGLLLVMTRHLCHRVQRGMEYAALKHLIPSDRRTLVVSGGVACNNFVAAGLQVLCDGMEYKLARPPHKLCTDNGVMIAWNGIERWRANKGITTDLDSITIEKSSPLGEDVRKDVELANIKPKWIKLTGLVNQNENVKKDVLQNNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AMK2</accession>
    <name>A0A5N4AMK2_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Carboxypeptidase</fullName>
            <ecNumber evidence="7">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PPYR_09552</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="7"/>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AMK2"/>
    <dbReference type="InParanoid" id="A0A5N4AMK2"/>
    <dbReference type="OrthoDB" id="735686at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF472">
        <property type="entry name" value="SERINE CARBOXYPEPTIDASE CPVL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024469392" description="Carboxypeptidase" evidence="7">
        <location>
            <begin position="20"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0798559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="435" mass="48812" checksum="893A609F87AE2158" modified="2020-02-26" version="1">MTPILSVLLIIAYSTIVSCDEDPLVLTPLLNSGKHEEAQTKSKVNLAALPNISSHSGYFKVSDTHNSHMFFWFFKSERNVTTDPIILCLQGGPGFTALIWPFLESGPLKVNSEIKLEKMPNSWTSFASVLYIDNPVGVGFSFGDRYPNNIDAVTVELYDAVRQFFQLFPTLKTNEFYIVGESYAGKYASRLGKKILEINAADSNKTINLVGIAFGNALVDPQRQFKYSEYLFHTGLISKAAKAKIKVLEDKLETGDSATVFEESGKIYDEFTKESGYQHIYSIKDQLGDHVLGMIKMDMFVDNEDFKKTLHVGTNEFLLYNGDIAGALTDLLVPIPKDVEYLLGKIRVLVYDGQSDVSVPLVGTINYLRQLNFDGSSDYKNGDREMWKLNNVLVGYITRAKKLTHVIVRNSGHMVPLDQHDVAYNMIMKFLSKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2024-05-29" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AML8</accession>
    <name>A0A5N4AML8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_09506</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AML8"/>
    <dbReference type="InParanoid" id="A0A5N4AML8"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902936">
        <property type="term" value="F:phosphatidylinositol bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1200">
        <property type="entry name" value="Alpha-tocopherol transfer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.20">
        <property type="entry name" value="N-terminal domain of phosphatidylinositol transfer protein sec14p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174">
        <property type="entry name" value="ALPHA-TOCOPHEROL TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174:SF216">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00180">
        <property type="entry name" value="CRETINALDHBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="87"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0798513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="307" mass="35397" checksum="C9329D075B3DEE6E" modified="2020-02-26" version="1">MPIRELPEELQKKTEKELNETPQRRTSDIDHIKDWLSKQPHLNVISPDDQWILNFLRGCKFSLDRTKEKLDNFYTVRSALPEFFGKRDPLSPEIQHILKLGLFLPIDTKVGPKIFLVRTANIDPTHVSLIDITKVCLMITDIILNEDDYCVIQGQRFLVDFSAFNKNQLLRVTPTLCQKAILCLKDVYPCRLKGFYIINMHPIFESIINVGKVIMGKKLGSRVVAYSKDNAQSLYDNIPKSALPADYGGEGETIEALTVKWKTKVESYRDMFLEDAKYGCDERKRIRKSVLSEHFGIEGSFRKLDID</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AMR0</accession>
    <name>A0A5N4AMR0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_09623</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="FunCoup" id="A0A5N4AMR0">
        <property type="interactions" value="13"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AMR0"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034518">
        <property type="term" value="C:RNA cap binding complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008190">
        <property type="term" value="F:eukaryotic initiation factor 4E binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901190">
        <property type="term" value="P:regulation of formation of translation initiation ternary complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22454">
        <property type="entry name" value="KH-I_Mextli_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000072">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040160">
        <property type="entry name" value="Mxt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20849">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-BINDING PROTEIN MEXTLI"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-BINDING PROTEIN MEXTLI"/>
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    </dbReference>
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        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="3">
        <location>
            <begin position="256"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="326"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="425"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="341"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="437"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0798630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="545" mass="60889" checksum="53A4F947A9DED053" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ANA1</accession>
    <name>A0A5N4ANA1_PHOPY</name>
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        <recommendedName>
            <fullName evidence="2">DUF5641 domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">PPYR_09691</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
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            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
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            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000327044">
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    </dbReference>
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        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
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        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF5">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18701">
        <property type="entry name" value="DUF5641"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="987"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF18701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0798698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1072" mass="122007" checksum="2D77C1F7324D313F" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AP75</accession>
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            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="common">Common eastern firefly</name>
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        <lineage>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Neoptera</taxon>
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            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
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            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="282" mass="33102" checksum="9165803DC146ECFA" modified="2020-02-26" version="1">MRKLQENIRHGRTCPYKYSALPLEFEYVVERIKPQRVCFGSAVQRDTNPIGRGISAFQKRFAYELNDKVTPQTYTYNHLTSGVARLANKVRSKKGVSGLCNGAERFPNKIFMRIPSPTRYTTEPFQKTFKQNFVPFNKKVGRKLTSLSRTPGPGHYCVTKKLCRRTKCDYNFGLPKIIPAVEVECTAKALHNCGRCGDICKDDYWHKNYTSFLCHICMEEEKVLREDFTMKQLKEFQKIRLCWYKHNHEGVDAYTQLYSDEKLKRRERCENYLNLYIDSINK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4APZ7</accession>
    <name>A0A5N4APZ7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">PPYR_07213</name>
    </gene>
    <organism evidence="2 3">
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        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
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            <taxon>Neoptera</taxon>
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            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
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            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
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                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4APZ7"/>
    <dbReference type="InParanoid" id="A0A5N4APZ7"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47353">
        <property type="entry name" value="Retrovirus capsid dimerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0799333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="478" mass="53256" checksum="DBEA84511E882AFB" modified="2020-02-26" version="1">MTTIDELQEQLNHLKAINNEQQELSRRQAEKLALVKATPPTDGQVMLKLFENVERLALGVAQATTPTSVLNITDRQFPKFEVDRPAEWPKFVTALNIAFSDTEGAMLSDSQKRRILLQNGGDSKLFNLAADLLKSNNLDITCATYQELLNTLGSFFKPKISHAALGLILFYAKFTGLRQNKNESALQFVARLRAAAADCNFGDKTEDLLLWQFVCGISNETVQQHLLNTEDKLSFQAAINKATTAECTTTHVRTLQGTEYTQQSSTATVFHAEAPQTLQRSSNENSHTNNKKKNRDKNHQQPTQRQTRGCYRCAGDHHSNNCSLDANTLYCTTCATWKHLAAACRGSRIGKQQPQINYKPQQQLNPPPRLSAPTHQLIADHSTSAPLQQYRTATTCTTTPSSQFGQQQSIYYHQSTKCQQTPGESDPVTQHRRQPANIYCTSAVPQFAPASPQLAGNTFFSNGIPQEALWRTQSPPTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ARI9</accession>
    <name>A0A5N4ARI9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_07845</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. MFSD6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ARI9"/>
    <dbReference type="FunCoup" id="A0A5N4ARI9">
        <property type="interactions" value="65"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4ARI9"/>
    <dbReference type="OrthoDB" id="6414167at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024989">
        <property type="entry name" value="MFS_assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051717">
        <property type="entry name" value="MFS_MFSD6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16172:SF27">
        <property type="entry name" value="FI19426P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16172">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 6-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12832">
        <property type="entry name" value="MFS_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="343"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="407"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="456"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="494"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="525"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="554"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="585"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="620"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily associated" evidence="8">
        <location>
            <begin position="15"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0799965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="686" mass="76336" checksum="0B1C3DB1D3B478B3" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ASZ3</accession>
    <name>A0A5N4ASZ3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Translation machinery-associated protein 16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_06176</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TMA16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000004">
        <property type="protein sequence ID" value="KAB0800436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ASZ3"/>
    <dbReference type="FunCoup" id="A0A5N4ASZ3">
        <property type="interactions" value="1056"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4ASZ3"/>
    <dbReference type="OrthoDB" id="270284at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1440.170:FF:000001">
        <property type="entry name" value="Translation machinery-associated 16 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.170">
        <property type="entry name" value="Translation machinery-associated protein 16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021346">
        <property type="entry name" value="Tma16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038356">
        <property type="entry name" value="Tma16_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13349">
        <property type="entry name" value="TRANSLATION MACHINERY-ASSOCIATED PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13349:SF2">
        <property type="entry name" value="TRANSLATION MACHINERY-ASSOCIATED PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11176">
        <property type="entry name" value="Tma16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0800436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="164" mass="19212" checksum="8C2EDC481D6C5F76" modified="2020-02-26" version="1">MRNLSKELSKCKHPNSRKTKALSKKTRRIILRNESNQVQNLKRSVIANKIQWFLDRVDSSVTKCSAQQTEELIESYLSRFDEELEQIAIKDSIGNRKNRQHANRQDVIKMTIQREKEEYNTCGLEMPNIMEEADLAAFRLWDGDLIALQHLKLVRISKVMLTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2024-05-29" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AT61</accession>
    <name>A0A5N4AT61_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_06257</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000004">
        <property type="protein sequence ID" value="KAB0800517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AT61"/>
    <dbReference type="InParanoid" id="A0A5N4AT61"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229:SF8">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0800517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="261" mass="27934" checksum="3F57790A483F5494" modified="2020-02-26" version="1">MMFPISGKVALITGGSEGIGAAIAKELLRAGLKGVTILGRSADKGTRMVEELTKEFGKGKAIFIRADVSTKEEIEEAFKKTVEIFNNIDIVVNNAVTLTKDWDRYITANLTGTITGTMLAYETYLPKYASDNKGVIINISSPSGLYGSPFSPLYAAAKSGSIALTISLGSDYHYNRTGIKVIAVCPGYTDTAAIDLGQDNFQGPAYYEAFVEAIKALPPPQPASVVGKAVVTVIKEARSGSVWMIHDSQPPYEVKTQVVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AVK7</accession>
    <name>A0A5N4AVK7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_05723</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000003">
        <property type="protein sequence ID" value="KAB0801369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AVK7"/>
    <dbReference type="InParanoid" id="A0A5N4AVK7"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000067">
        <property type="entry name" value="NK6 homeobox 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050394">
        <property type="entry name" value="Homeobox_NK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000047">
        <property type="entry name" value="HTH_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24340:SF35">
        <property type="entry name" value="HGTX, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24340">
        <property type="entry name" value="HOMEOBOX PROTEIN NKX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00031">
        <property type="entry name" value="HTHREPRESSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="232"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="234"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="297"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="310"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0801369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="333" mass="36937" checksum="78B0892AD2DB0CD3" modified="2020-02-26" version="1">MTQHSDASSDRSEVSISPPPPVSKMLEFASQQNLNFLNLEHRNMLAAPLAALHSMTEMKVHQQPHMSPSDHQMLLQDKHDVDVLLERTSVHVERSGLSSRSPLGATVNTNSQGANPHGIDHILSRPSQITTGNFHFPHNLSFPQNALSMASNSSQTATNSGLRGFNIAAAAFFHHHAANSVNKPVELGRNTAGIYWPGFQGLVANPMAWRERLNLNSMNQGGLGGVGPDKDAKKKHTRPTFSGQQIFALEKTFEQTKYLAGPERAKLAYALGMTESQVKVWFQNRRTKWRKKHAAEMATAKRKQEVLDNQTDENSDVISDTDEEHSAKRQNIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AVP7</accession>
    <name>A0A5N4AVP7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="26">Aminopeptidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">PPYR_05687</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">1611_PpyrPB1</strain>
            <tissue evidence="24">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="18">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000003">
        <property type="protein sequence ID" value="KAB0801333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AVP7"/>
    <dbReference type="InParanoid" id="A0A5N4AVP7"/>
    <dbReference type="OrthoDB" id="6750768at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09601">
        <property type="entry name" value="M1_APN-Q_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1910:FF:000003">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.50.20:FF:000005">
        <property type="entry name" value="Aminopeptidase N-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1730:FF:000001">
        <property type="entry name" value="Leucyl-cystinyl aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000006">
        <property type="entry name" value="Puromycin-sensitive aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034016">
        <property type="entry name" value="M1_APN-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF299">
        <property type="entry name" value="AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="14 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10 18" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="23">
        <location>
            <begin position="158"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="21">
        <location>
            <begin position="380"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1-like C-terminal" evidence="22">
        <location>
            <begin position="682"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="17">
        <location>
            <position position="453"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="452"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="456"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="475"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="19">
        <location>
            <position position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KAB0801333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="26">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1019" mass="116857" checksum="13CA85CA2070D3B8" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AWX8</accession>
    <name>A0A5N4AWX8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PPYR_03934</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs. Down-regulates NF-kappa-B signaling by competing with RELA for CREBBP/EP300 binding. Involved in the microRNA (miRNA) biogenesis. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0801748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AWX8"/>
    <dbReference type="InParanoid" id="A0A5N4AWX8"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22718">
        <property type="entry name" value="FHA_SNIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.20:FF:000008">
        <property type="entry name" value="smad nuclear-interacting protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050923">
        <property type="entry name" value="Cell_Proc_Reg/RNA_Proc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23308">
        <property type="entry name" value="NUCLEAR INHIBITOR OF PROTEIN PHOSPHATASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="6" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="FHA" evidence="13">
        <location>
            <begin position="202"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="26"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="294"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="26"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="76"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="89"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="111"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="307"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00055964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAB0801748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="318" mass="38181" checksum="B46DBF5D90AC6D70" modified="2020-02-26" version="1">MTVKYLNEQECNVIFLLTRNDSRSAYENKHNDDKRRKHKDVDRRDRNDDRAHDYRNKSKERDNYHHQRDRGRDYRQNNYRNRYGNNENDDYRRNRREDQYSRNRRGRSRSRSFDHANAKWGKEDKGRDKSGKDKDKEVKKEKEKPNFGLSGKLTEETNTYRGVVIKYSEPPEARKPKRRWRLYPFKGDKALQTLYIHRESAYLIGRDRKVVDLPVDHPSCSKQHAALQYRLVTFTREDGTTGKRVRPYLIDLESANGTFINNKKIEAKKYVELLERDVIKFGFSSREYVLLHENSKDEAQDDDVKIEEEVPVKKESNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AXR4</accession>
    <name>A0A5N4AXR4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_04341</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AXR4"/>
    <dbReference type="InParanoid" id="A0A5N4AXR4"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF74">
        <property type="entry name" value="POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
        <property type="entry name" value="HTH_psq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH psq-type" evidence="4">
        <location>
            <begin position="21"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="DDE-1" evidence="3">
        <location>
            <begin position="224"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="544"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="601"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="562"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="602"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0802155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="622" mass="69669" checksum="F7B2E61F64A4369E" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AXV9</accession>
    <name>A0A5N4AXV9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ionotropic glutamate receptor C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PPYR_04391</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AXV9"/>
    <dbReference type="FunCoup" id="A0A5N4AXV9">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AXV9"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050906">
        <property type="term" value="P:detection of stimulus involved in sensory perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF24">
        <property type="entry name" value="IONOTROPIC RECEPTOR 60A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="501"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="581"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="745"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="10">
        <location>
            <begin position="509"/>
            <end position="752"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0802205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="781" mass="89665" checksum="D34ED7BFDE85781B" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AZ68</accession>
    <name>A0A5N4AZ68_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">NADH-cytochrome b5 reductase</fullName>
            <ecNumber evidence="8">1.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PPYR_04769</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46680"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7 8">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.2" evidence="8"/>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AZ68"/>
    <dbReference type="FunCoup" id="A0A5N4AZ68">
        <property type="interactions" value="374"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AZ68"/>
    <dbReference type="OrthoDB" id="432685at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090524">
        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NADH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019180">
        <property type="entry name" value="Oxidoreductase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370:SF184">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09791">
        <property type="entry name" value="Oxidored-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 8" id="KW-0274">FAD</keyword>
    <keyword evidence="3 7 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 8" id="KW-0520">NAD</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="9">
        <location>
            <begin position="49"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601834-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0802583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="291" mass="33394" checksum="A5F002105E86A8B3" modified="2020-02-26" version="1">MEPPLKPNEADCCNSGCNPCIFDVYEDQLNKYLNKQLYISDARNCLSQTAYTAFTLKEIKPHAKNTFIYTFRYGNTPDNCNRVLYKPGQHLLMKADDNAVQFTRAYTPIPGDGTDLLSFTVLVKLYENGAMSAFFRNLRMNDDVLWRGPYGDYEVDYGLSRLLLIAQGTGIAPLYTIAHDILHNESCETFVHLFLCSRTEDDIPLRDELYQLASYWNFTYEIFLSQATRVRCKYNETVHDFRLSSNEIEAYFLRISDDRLQVLICGSDAFNVDVSRLVTECKTDGTEIVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B059</accession>
    <name>A0A5N4B059_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4371 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_05168</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B059"/>
    <dbReference type="InParanoid" id="A0A5N4B059"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025398">
        <property type="entry name" value="DUF4371"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45749">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45749:SF21">
        <property type="entry name" value="DUF4371 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14291">
        <property type="entry name" value="DUF4371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4371" evidence="1">
        <location>
            <begin position="11"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0802982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="207" mass="23559" checksum="207F4D08A34D0E38" modified="2020-02-26" version="1">MDLDKKMKFETNYWVKVLERVINVTLTLAENNVSFRGAHESLYDGDNNRGNFLNIIKLLAIYDPVLQELLSKDKNSVKYLSPTIQNEIIELLATEVKTKLIGQINESPFFSIIMDTTQDIAKVDQVSFVIRFVHLIKDADTVNIVHDAEDMVNQLLSFFEKNNLSVEKLRAQGYDGAANMSGIYNGLQAKILEKQPNALYVHILHTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B0G3</accession>
    <name>A0A5N4B0G3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH psq-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_00052</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B0G3"/>
    <dbReference type="InParanoid" id="A0A5N4B0G3"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
        <property type="entry name" value="HTH_psq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH psq-type" evidence="2">
        <location>
            <begin position="23"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0803082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="195" mass="22430" checksum="02C6EFDDF569FBE4" modified="2020-02-26" version="1">MRTVYKKKAPCQLKRPARQANISPDVFQRALDDIRNKVKSVRQAAADYNSPKSTLFGYVKSKRVPGNQTYSSKFVSRQLFTDCEEKALAEYLITAANMHYGLNINQVKELAYNYAVANSKKVPDNWWVNGRASKDWLKGFLQSLIQPLFTILMKLGFKQFTDQAKLLQRKAENKSDALRLAKKEKRSSFVQLLMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B0U5</accession>
    <name>A0A5N4B0U5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF5641 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_00189</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4B0U5"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040676">
        <property type="entry name" value="DUF5641"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008042">
        <property type="entry name" value="Retrotrans_Pao"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF5">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18701">
        <property type="entry name" value="DUF5641"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05380">
        <property type="entry name" value="Peptidase_A17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5641" evidence="2">
        <location>
            <begin position="932"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1257"/>
            <end position="1292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1257"/>
            <end position="1267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1268"/>
            <end position="1279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0803219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1322" mass="152108" checksum="B5ED19C2FACFA254" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B2D8</accession>
    <name>A0A5N4B2D8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PPYR_00725</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B2D8"/>
    <dbReference type="InParanoid" id="A0A5N4B2D8"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007420">
        <property type="term" value="P:brain development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050877">
        <property type="entry name" value="EMX-VAX-Noto_Homeobox_TFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24339">
        <property type="entry name" value="HOMEOBOX PROTEIN EMX-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24339:SF30">
        <property type="entry name" value="LATERAL MUSCLES SCARCER, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="7">
        <location>
            <begin position="106"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="108"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0803755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="269" mass="31082" checksum="E5EDBB764B89D4D9" modified="2020-02-26" version="1">MNESLCTESQDDKKVKSNNFSIESILSKIDSGRDLDYHHTESECQMSSVQKLCATSESGYSESNEVEFIDEKVNDASENDSSSASENRLNKFSNDIAYFDCRSDDDRKKRPRTAFTASQIKSLEAEFEKNKYLSVAKRNQLSKTLKLTETQIKIWFQNRRTKWKRKYTNDVELLAQQYYNSMGFFVPRPIFLGDRLWFFNCQNQTTMSNLNHFVQPSTSIVPLPQTALPHVSPQVSQSCSQHYVSFQDPMPETPAILQLQNFGRHFDNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B2R0</accession>
    <name>A0A5N4B2R0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Integrator complex subunit 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">PPYR_00871</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">1611_PpyrPB1</strain>
            <tissue evidence="23">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Forms a water-specific channel.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. INTS11 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B2R0"/>
    <dbReference type="FunCoup" id="A0A5N4B2R0">
        <property type="interactions" value="1580"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4B2R0"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048878">
        <property type="term" value="P:chemical homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016180">
        <property type="term" value="P:snRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16291">
        <property type="entry name" value="INTS11-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00333">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1080.10:FF:000009">
        <property type="entry name" value="aquaporin-4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10890:FF:000002">
        <property type="entry name" value="Integrator complex subunit 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.15.10:FF:000028">
        <property type="entry name" value="Integrator complex subunit 11 isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022712">
        <property type="entry name" value="Beta_Casp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041897">
        <property type="entry name" value="INTS11-like_MBL-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048662">
        <property type="entry name" value="IntS11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050698">
        <property type="entry name" value="MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022357">
        <property type="entry name" value="MIP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00861">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11203">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11203:SF37">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10996">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21386">
        <property type="entry name" value="IntS11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16661">
        <property type="entry name" value="Lactamase_B_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SMART" id="SM01027">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00221">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="17 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0677">Repeat</keyword>
    <keyword evidence="11 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
    <keyword evidence="15" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="588"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="663"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="705"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="779"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="21">
        <location>
            <begin position="4"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-Casp" evidence="22">
        <location>
            <begin position="233"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="23">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00007093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00016810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00056455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="SMART" id="SM01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KAB0803901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="811" mass="90325" checksum="DBA99C18D673EC30" modified="2020-02-26" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B4E5</accession>
    <name>A0A5N4B4E5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PiggyBac transposable element-derived protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_01435</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B4E5"/>
    <dbReference type="InParanoid" id="A0A5N4B4E5"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599:SF3">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="2">
        <location>
            <begin position="118"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0804465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="279" mass="32873" checksum="184F4FA6AA1BCFBC" modified="2020-02-26" version="1">MWSYESEQARLQELLELEILNDEGQGIAYDDHSDTDQSDEEEDRVEQQNENSDTEQDISDDEEMGEESPNSRLSFYGKDKVTRWRKVVSHPKTRKTRQMNIVKRLPGSSLTTRNLREPLEIWEYFFNDEILDIIVECTNEYIESVRNNFMRKRDATPTNLIEIRAFIGVIYMAGVYHANRLNAEDLWSNDGSGVEIFRLAMSLQRFRFLIRCLRFDSKETRAMRRETDKLAPIRNVFDRFVANCQNGFHHSEFVTVDEMLAGFRGKCSFRQSSYKVWTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B4P2</accession>
    <name>A0A5N4B4P2_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxylesterase type B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_01506</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B4P2"/>
    <dbReference type="InParanoid" id="A0A5N4B4P2"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000092">
        <property type="entry name" value="Carboxylic ester hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142:SF1">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="6">
        <location>
            <begin position="4"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="6">
        <location>
            <begin position="545"/>
            <end position="1065"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0804536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1078" mass="120751" checksum="A4A500ED2D255F2E" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B5U9</accession>
    <name>A0A5N4B5U9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PPYR_01961</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B5U9"/>
    <dbReference type="InParanoid" id="A0A5N4B5U9"/>
    <dbReference type="OrthoDB" id="6602337at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="2"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0804991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="193" mass="22301" checksum="02F1220795CBA21D" modified="2020-02-26" version="1">MFMCEKCNKSFATNSNLRRHLKKSCRAQEPSPKKLKVTHDTQRFCDVCSEHVSSRDYVGHLRSVKHKNNSLAFSTEGVQVITSAFKSRIVSYRISANTQYINLKEFVESLADVIKKLVREQIDIMGSVKVNCELFGYFILESKDRGEVKSFNTRNQVLTISSDLSEWFKDIIEKLEVDATEFEHRESGWALQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B6E1</accession>
    <name>A0A5N4B6E1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Integrase zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_02147</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0805177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B6E1"/>
    <dbReference type="InParanoid" id="A0A5N4B6E1"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040676">
        <property type="entry name" value="DUF5641"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF5">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18701">
        <property type="entry name" value="DUF5641"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase zinc-binding" evidence="1">
        <location>
            <begin position="147"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5641" evidence="2">
        <location>
            <begin position="217"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0805177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="265" mass="30296" checksum="5B9EAB4AFFE297A3" modified="2020-02-26" version="1">MDRSLTQLDPLSFDKDSDSTIKILGLHLWDNLLTKFSSLSKILRTCAYVLRFVSYVEDPKGFDKRSHVTLKELDRALLILVKESQKMSFAKELAELSKTTPNIRSLPKYIRKLTPFLDQDGILRVGGRLKNTPLSYDHKHPCLLPSDHRLTNLIIEYTHIKYLHPGLQTTQFLLSQRFWIPSSKRVIKKVLSSCLRCFKCNPSSCTPLMGDLPKFRENSPPLHWALGRVIECFPGADGVTRVVNVKTQKGILRRPVSKLCLLPNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B6G3</accession>
    <name>A0A5N4B6G3_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_02155</name>
        <name evidence="1" type="ORF">PPYR_12243</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0795404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0805185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B6G3"/>
    <dbReference type="InParanoid" id="A0A5N4B6G3"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0795404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0805185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="104" mass="11676" checksum="A16E5C50D6D8F269" modified="2020-02-26" version="1">MDLNKSLQRINAIGNAVERTVIKVRDMEVGKIYEIEKIKAISTQYGRGIVCEIAGNASIFLPQRMVKEMEENVIDQLNNLRMGVVLNGFLKNDTPKVELITIGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B7B4</accession>
    <name>A0A5N4B7B4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phosphatidate phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PPYR_02436</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:27429"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="3.1.3.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:27430"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the lipin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.4" evidence="4"/>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0805466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B7B4"/>
    <dbReference type="FunCoup" id="A0A5N4B7B4">
        <property type="interactions" value="950"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4B7B4"/>
    <dbReference type="OrthoDB" id="4567at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032869">
        <property type="term" value="P:cellular response to insulin stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026058">
        <property type="entry name" value="LIPIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031703">
        <property type="entry name" value="Lipin_mid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007651">
        <property type="entry name" value="Lipin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013209">
        <property type="entry name" value="LNS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031315">
        <property type="entry name" value="LNS2/PITP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12181">
        <property type="entry name" value="LIPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12181:SF12">
        <property type="entry name" value="PHOSPHATIDATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16876">
        <property type="entry name" value="Lipin_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04571">
        <property type="entry name" value="Lipin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08235">
        <property type="entry name" value="LNS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00775">
        <property type="entry name" value="LNS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LNS2/PITP" evidence="7">
        <location>
            <begin position="736"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="219"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="450"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="240"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="459"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0805466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="946" mass="105806" checksum="1464B93E2E1E67B1" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B7E2</accession>
    <name>A0A5N4B7E2_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Sister chromatid cohesion protein DCC1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_02466</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DCC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0805496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B7E2"/>
    <dbReference type="FunCoup" id="A0A5N4B7E2">
        <property type="interactions" value="1286"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4B7E2"/>
    <dbReference type="OrthoDB" id="5199543at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034088">
        <property type="term" value="P:maintenance of mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019128">
        <property type="entry name" value="Dcc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13395:SF6">
        <property type="entry name" value="SISTER CHROMATID COHESION PROTEIN DCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13395">
        <property type="entry name" value="SISTER CHROMATID COHESION PROTEIN DCC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09724">
        <property type="entry name" value="Dcc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0805496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="398" mass="46179" checksum="CC1A170294559C1D" modified="2020-02-26" version="1">MESTHDEPFADNQTQEIEKTLLLAKLKPEDLLPLTQVVYFASEELHHNNYKLLQIDNCLLETFNEQGVVYVKGEDNENAVLCTDTATYDLLETETSNALLLVESLHFRDSVTDSAPKATSKVTVKGVFYDYLEVTPTKPNLQRLHELLDKRPYKGPEYERDGDEHDLYTYSELLNRIQASRNELDAALEAMRIVKVNDKIRILDFEYHSRVLSYMLKLIEENSWNFNEVDYDQTVSTLSDLIPEEIICSLFELYTEKSKVIDGLQLYKYKEIDVCKFVARVLLHNARKFNLQEFLEAWMELVPNGMRPETEMLYGLAIIDTKSVPNTILAFEEETLPDNILERFDVLFNAKDRWTVPEITPYIQRMTTEKTDVNAILAKYARACTFSGVKYYTAKHSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B7N2</accession>
    <name>A0A5N4B7N2_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_02534</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0805564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B7N2"/>
    <dbReference type="InParanoid" id="A0A5N4B7N2"/>
    <dbReference type="OrthoDB" id="410651at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042869">
        <property type="entry name" value="ARHGAP11A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15670">
        <property type="entry name" value="RHO GTPASE ACTIVATING PROTEIN 11A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15670:SF4">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 11A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="2">
        <location>
            <begin position="52"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="491"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="736"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="351"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="516"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="526"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="740"/>
            <end position="757"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0805564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="757" mass="85977" checksum="7701E52A01B5099D" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1JRI9</accession>
    <name>A0A1Y1JRI9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PPYR_14381</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">1611_PpyrPB1</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">1611_PpyrPB1</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="GEZM01102743">
        <property type="protein sequence ID" value="JAV51812.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1JRI9"/>
    <dbReference type="FunCoup" id="A0A1Y1JRI9">
        <property type="interactions" value="1059"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1JRI9"/>
    <dbReference type="OrthoDB" id="40902at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008361">
        <property type="term" value="P:regulation of cell size"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14089">
        <property type="entry name" value="STKc_MAPKAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000094">
        <property type="entry name" value="MAP kinase-activated protein kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000156">
        <property type="entry name" value="MAP kinase-activated protein kinase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1170.10:FF:000001">
        <property type="entry name" value="MAP kinase-activated protein kinase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1170.10">
        <property type="entry name" value="MAP kinase activated protein kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050205">
        <property type="entry name" value="CDPK_Ser/Thr_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027442">
        <property type="entry name" value="MAPKAPK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24349">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="203"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="21"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="JAV51812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAB0792422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="355" mass="40775" checksum="793454679C470D73" modified="2017-08-30" version="1">MNIMKSQVRTPKPTLLTNDFEITSTVLGLGINGKVVECFSKSKKEKFALKVLHDSLKARREVDLHWRASGCRHIVNIIDVYENTYNGNTCLLVVMECMEGGELFQRIQGRQDGAFTEREAAQIMHEICIAVKYLHDNNIAHRDLKPENLLYTKEGPLGILKLTDFGFAKETLTKDTLQTPCYTPYYVAPEVLGPEKYDKSCDIWSLGVIMYILLCGFPPFYSNHGLAISPGMKKRIRMGQFNFPNPEWQNVSKDAKELISGMLNVDPAERLTIDEVMRNRWIAQYTAVPQTPLHTNRMLKEGEEIWPEVQEEMTRSLATMRVDYDQVHIKALENSNNPLLNKRRRRAVPIRDNKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1JSL0</accession>
    <name>A0A1Y1JSL0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Putative nuclease HARBI1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Harbinger transposase-derived nuclease</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PPYR_00143</name>
        <name evidence="18" type="ORF">PPYR_00690</name>
        <name evidence="16" type="ORF">PPYR_09510</name>
        <name evidence="15" type="ORF">PPYR_10933</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15 19" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">1611_PpyrPB1</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">1611_PpyrPB1</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Transposase-derived protein that may have nuclease activity. Does not have transposase activity.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HARBI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01101829">
        <property type="protein sequence ID" value="JAV52262.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1JSL0"/>
    <dbReference type="InParanoid" id="A0A1Y1JSL0"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026103">
        <property type="entry name" value="HARBI1_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF85">
        <property type="entry name" value="GH03217P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02086">
        <property type="entry name" value="PUTNUCHARBI1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="13">
        <location>
            <begin position="109"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="JAV52262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAB0796872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAB0798517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAB0803173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAB0803720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="319" mass="35854" checksum="29F149C72A9CD0A3" modified="2017-08-30" version="1">MQRKTFDFILSLIGPKISENVVKPGRPSVSPETQLLLTLWILGTPDSYRSVSDRFNVGKATAVISVRRVVKALYDHVHTFIKWPIADEMETSIRVFRAVKGFPNVIGAIDGTHISITAPKNNAEAYVNRKGYHSMQLQAVCNENGMFIHCFTGYPGAVHDQRVFQNSDLPEFFRNDTQFPDDVHILGDAAYKLHKHLMVPFKDNGHLTDIQKNFNMCHSSTRMAIERAFGLLKGRMRRLLDTLPMTREDLIPKYIITCCILHNICLLKQDQFQPLAVAISNNASAVEILATREPDGGGRDVAIRKRDVIAAELPMQIGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1JW19</accession>
    <name>A0A1Y1JW19_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PPYR_15728</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GEZM01101733">
        <property type="protein sequence ID" value="JAV52350.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01101732">
        <property type="protein sequence ID" value="JAV52351.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01002117">
        <property type="protein sequence ID" value="KAB0789982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1JW19"/>
    <dbReference type="FunCoup" id="A0A1Y1JW19">
        <property type="interactions" value="311"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1JW19"/>
    <dbReference type="OrthoDB" id="6365358at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18315">
        <property type="entry name" value="BTB_POZ_BAB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051095">
        <property type="entry name" value="Dros_DevTransReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23110">
        <property type="entry name" value="BTB DOMAIN TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23110:SF102">
        <property type="entry name" value="PIPSQUEAK, ISOFORM O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="31"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="122"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="235"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="404"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="477"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="168"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="481"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="JAV52351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0789982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="499" mass="55909" checksum="CCB542CF666DD4B0" modified="2017-08-30" version="1">MLPQQYCLRWRYHHSNLQTMFSQLLEREAFCDVTLACEGKTLKAHKIVLSACSTYFDTILSQYEEKDPILIMKDVKYVDIKCLVEFMYKGEINVDHCHLATLLKTAEELRIKGLAEVSWRDEEGNNDTSVNGVQSALPNVSTVMDSPKNEPPNKRKRGRPPIDDYEQAFTTPKITSVTGNAEEGYSNDALSSSDQDLSIWEEESAANDNDQTELDEPPPKIKSESLQEDDLLMDDSAMDLGPDSKFDLQSSGGQNKGNNGAKQSTNSSNSATTSCLTAAIEKEWPDVIKMNDYLSTGRRQQFWEEPFTKRVMDAIKTKNLEMKIAAELLGVSYGTLYGRYRDAYGCLKHPYRVRDFWSEQGPTDILLKLKRKEVTLFRAAEQLNVTPQTLSNYLISMSQLDNETMTPHGSIDKYDDGESDEDGDSILPDLPSNINVYKNMKSSNNSPASSTSNATTSVLANCPDVTVIKKEKLEGLIGKMNNNSDHSSSQSNNSDQIQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1JY47</accession>
    <name>A0A1Y1JY47_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Delta-aminolevulinic acid dehydratase</fullName>
            <ecNumber evidence="4">4.2.1.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Porphobilinogen synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PPYR_00867</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="20 21" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">1611_PpyrPB1</strain>
            <tissue evidence="20">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">1611_PpyrPB1</strain>
            <tissue evidence="20">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>2 5-aminolevulinate = porphobilinogen + 2 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58126"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="4.2.1.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Homooctamer; active form. Homohexamer; low activity form.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the ALAD family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.24" evidence="4"/>
    <dbReference type="EMBL" id="GEZM01097362">
        <property type="protein sequence ID" value="JAV54252.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1JY47"/>
    <dbReference type="FunCoup" id="A0A1Y1JY47">
        <property type="interactions" value="937"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1JY47"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00318"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004655">
        <property type="term" value="F:porphobilinogen synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000048">
        <property type="entry name" value="Delta-aminolevulinic acid dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001731">
        <property type="entry name" value="ALAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006762">
        <property type="entry name" value="PRK09283.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11458">
        <property type="entry name" value="DELTA-AMINOLEVULINIC ACID DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11458:SF0">
        <property type="entry name" value="DELTA-AMINOLEVULINIC ACID DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00490">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001415">
        <property type="entry name" value="Porphbilin_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00144">
        <property type="entry name" value="DALDHYDRTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01004">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="15">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="15">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>5-aminolevulinate</name>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>5-aminolevulinate</name>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>5-aminolevulinate</name>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>5-aminolevulinate</name>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU004161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="JAV54252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAB0803897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="335" mass="37241" checksum="874ED02CC08F148C" modified="2017-08-30" version="1">MFPQKNHYLHSAIGHPTLREWQSINHQITPKNLMYPIFVIDEENEEQPIDAMPGVSRFGINRLRAHLEPLVAKGLSSVLLFGVISQLPKDDQAFHADSNENPVIKVIPKLKEWFPELLIACDVCLCPYMSHGHCGVLHTDGTINNSLSIKRIAEVAVAYAKAGAHVVAPSDMMDGRVGAIKELLIKNDLVHKVAVLSYAAKFSSTFYGPFRDAAKSKPAFGDRKCYQLPPGGEGLALRSTTRDIQEGADMLMVKPALAFLDIVKQTKQTHPEYPLFAYQVSGEYAMIYHAAQKGAFELKVALQEILLSMRRAGADVIISYFTPMILDWLTLKSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1JZX3</accession>
    <name>A0A1Y1JZX3_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PPYR_08554</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
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            <taxon>Elateroidea</taxon>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
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            <dbReference type="DOI" id="10.1038/srep38556"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
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        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
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    </evidence>
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    </evidence>
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    </evidence>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
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            <authorList>
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                <person name="Bessho-Uehara M."/>
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                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
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                <person name="Oba Y."/>
                <person name="Weng J.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </evidence>
    <sequence length="1373" mass="156936" checksum="6E8BCFBBD2CF6700" modified="2017-08-30" version="1"> </sequence>
</entry>
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        <name evidence="3" type="ORF">PPYR_14638</name>
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        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
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            <taxon>Neoptera</taxon>
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            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
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            <taxon>Elateroidea</taxon>
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            <taxon>Photinus</taxon>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
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                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
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        <property type="protein sequence ID" value="JAV54560.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
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        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
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            <begin position="101"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="JAV54560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0792679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="334" mass="38178" checksum="961CC95198B142AA" modified="2017-08-30" version="1">MGERKWVSEADEYVCALSEDTQKIAKDTLGEDKNVRDQALESMRHWITHNPRILNCRLDSNFLLRFLRFSKFSVVQAQIALERYLLLRQSYGMVFREMDIKIPKMTELLQTGFLFVCPKRDKNGRRVYIIRPGAFDLSKYTNADMLKIAGIAFETLIEDEENQVKGFVYLADGQGCGLPYVTLFTPLEMVRLVKNGEKTVPARHIEIHGLNVHPTMKFAYEFGISLISEKIRKRIKLYSTIEEFLAGGTMELDILPKEYGGTTPMSEMIDNWKEELLNENARLLSHDEMAVQEELFSSKERDGAVSALRASGGTCGNEDSMYGVTGNFRKLEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1K5R5</accession>
    <name>A0A1Y1K5R5_PHOPY</name>
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        <recommendedName>
            <fullName evidence="5">MIF4G domain-containing protein</fullName>
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    <gene>
        <name evidence="8" type="ORF">PPYR_08210</name>
        <name evidence="7" type="ORF">PPYR_13428</name>
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    <organism evidence="6">
        <name type="scientific">Photinus pyralis</name>
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    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
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                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
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            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="JAV55811.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KAB0793808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KAB0797216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="term" value="C:cytosol"/>
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        <source>
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        <source>
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        <source>
            <dbReference type="EMBL" id="KAB0797216.1"/>
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    </evidence>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1KC55</accession>
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            <fullName evidence="3">OTU domain-containing protein</fullName>
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
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                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
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        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
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                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
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        </source>
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        <location>
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        <location>
            <begin position="19"/>
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        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="98"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="JAV57971.1"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAB0800480.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="298" mass="33983" checksum="36F9CDEA06E691BE" modified="2017-08-30" version="1">MEVVEDVIEKSPLNEEELLKKHRQERKDLQAQIQSLKKGVVKGDKKKKKEVTEMISKLEQELDAEQALELNNVAANDTVSSELSSINEVVNGDVPTKISRAQKRRTKKETENKEREKRIAEEEVNHRQGPRVVELNTIKELLQNEGLQIFNIPADGNCLYCAINHQLEVTGRVSSNVSKLRKLTASFIRDNKEEFLPFMYNDDDDELIGEDKFEKYCKDVANTKLWGGQLELTALSSVLKCPIKVIQASGPLTIQAEQYEGPPLILTYHKHLYRLGEHYNSTITSVDDNMQESEDTFA</sequence>
</entry>
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        <name type="scientific">Photinus pyralis</name>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
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                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
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        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
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    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01090307">
        <property type="protein sequence ID" value="JAV57297.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="473" mass="53897" checksum="1A859628494FC35F" modified="2017-08-30" version="1">MDLALLISEAVLIDGDKVKVKACTNGDDLVINEHSLQFNLHSSIFPSLIDVSSLVSLNLSACKLTFLPDDLKNLSLTELDLSKNAFREVPKCIYDGLKVLQVLNFSHNKLSWFDAPRCLIKLRVLKINHNDFMDIPPWILKVFALNLEELDYSHNCIISLKACRFYLTPMHCLNKLELRNCEMRSDDFKYLKTIRTLKHLDIGNDESASTMNSFVSNDLLQLFISPHWAKNLTVLSLNYLYISDLPAEISNLPALEELHLRNNELLWLPEAFLIPTLQLLDLSFNRVAILPKNLSGMPKLRILRLEANGLETLPVMPSHLEELDLYNNKLETYCNTQGDLRKLDLEMNYFDTSTLGDFERYLEMKTAIRGGGDCFRNDGFHRIPEPEDEESDTDSEIDSYCDNDEVRSAGDGCVEECWDDEQWGEGAKFSGDDGVTLSDVEFNGYQEDPPKPKVQGARVVLPDWVYCDVPSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1KFT6</accession>
    <name>A0A1Y1KFT6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Piwi domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PPYR_07248</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Photinus pyralis</name>
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            <taxon>Coleoptera</taxon>
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    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
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            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
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    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the argonaute family. Piwi subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="JAV58475.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="entry name" value="Piwi-like RNA-mediated gene silencing 1"/>
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    </dbReference>
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        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
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    </dbReference>
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        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23278">
        <property type="entry name" value="Piwi_N"/>
        <property type="match status" value="1"/>
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</entry>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
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                <person name="Fallon T.R."/>
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                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
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        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
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</entry>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
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            <dbReference type="PubMed" id="28004739"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
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        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
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                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
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        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
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                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
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        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="EMBL" id="JAV65576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0798283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="165" mass="18746" checksum="2A520821A32E4CBC" modified="2017-08-30" version="1">MIDSQNKRCHHKHIEDVIDARKKLSNFDTYENPPKRRPLSAPVASISKKSSYCLLHDTTNWSNEADLEPSDSEVTIIRIKKRGLRNRTLENKWNLKDQAIPGDGTHFARSPSLINLVTLVRRGCGNANESCTQEYMVPLSSWEPYAFDESDCESLAGLGYTAFKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1L2M1</accession>
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    <organism evidence="5">
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        <lineage>
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                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
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            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAB0800281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0800283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="433" mass="49012" checksum="39A2374ECB4816C7" modified="2017-08-30" version="1">MSHRGGQDPQPGYMDEVCVKISEKYKPPPRINLAITYAQRLYLNKQIQYSIIPYDFSLETSIKDRVRELRSARRQLYEDQADRLKEARLKYEQFLEDKKSKESISNVSQESEIPEEQILKASGTTSGVMYPTSYSHILTPTPLSNTDTKVLFKCNSNDKSPFNISDFEADTSSPFDNMELKTINDIEELAQVLKKGETSNHSYAIPYTDAAGQAFPNYVSLPSTSGQSTTVSTYAVQDTRNLPYSPYISQTLSPYTHSITSRTYNNLNGYYYTSDIVQTNVNQNFKLDQLPYNYDNSSSKLSKENTKSIPDIMKTLESELKSTKICQNGVPSDPNKSQESSTEVVIKSIDLDDVFSHLPKNLQYLSKDISLMGFPLSRVARVCQTIGDNQKKIVEHLIVMSELLDLGFSEEEVSRALLQCNNDRDKALDILIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1L7C9</accession>
    <name>A0A1Y1L7C9_PHOPY</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_07173</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01068360">
        <property type="protein sequence ID" value="JAV66967.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
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            <end position="428"/>
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    </feature>
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            <end position="292"/>
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        </location>
    </feature>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAB0799293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="428" mass="50155" checksum="E281F3F0C82F6806" modified="2017-08-30" version="1">MVALRLLPALQIIFILCTPCLSYPVFGTKRYNGRSAVLRRANNNYSWGTSVQPYQQFLRAQRFPVNYYEMYPYGRDYQDDYYYPQETISYPLYIPPPRTSKYEVYQAVLPYYYGDRPLARQDYGYYGYEKSAEPIENLEDDIIQEAQREEREDAQPIGQEVLYENEDGEESLDDVNAAFLQNLIMSQMYKDASSKQKNYYDQYPSTDYYYDEDNYEKWDDTQVLPKQTYQEDEDVRELKQLVKPQRQDVFGLQKGPSAEERLHLFRNENKNKNPKGKFADKHGWDGKRSKSNAASMGSLRYTVNDFPRNDLPLVLKATSSPAVTPTSLPKATSTSPKRDSRKGQKEEVLMRPATPIKNPFSSKVLEMMKEPERKREPSVYDTIKHMLDVEKSLENSYRANEMRSPMRKRIITDEDSLIQQLSLLKKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1L8E1</accession>
    <name>A0A1Y1L8E1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PPYR_00403</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">1611_PpyrPB1</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">1611_PpyrPB1</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GEZM01062288">
        <property type="protein sequence ID" value="JAV69864.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000327044">
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    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:endoplasmic reticulum"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070936">
        <property type="term" value="P:protein K48-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="CUE_AMFR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="E3 ubiquitin protein ligase RIN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="CUE"/>
    </dbReference>
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        <property type="entry name" value="TPR_SYVN1_N"/>
    </dbReference>
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        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15067:SF5">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE AMFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15067">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
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    </dbReference>
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        <property type="entry name" value="TPR_SYVN1_N"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RING"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ZF_RING_2"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="12"/>
            <end position="32"/>
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    </feature>
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        <location>
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            <end position="110"/>
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    <feature type="transmembrane region" description="Helical" evidence="12">
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    <feature type="transmembrane region" description="Helical" evidence="12">
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    <feature type="transmembrane region" description="Helical" evidence="12">
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    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
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        <location>
            <begin position="359"/>
            <end position="397"/>
        </location>
    </feature>
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        <location>
            <begin position="464"/>
            <end position="506"/>
        </location>
    </feature>
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        <location>
            <begin position="509"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="520"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="548"/>
            <end position="558"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
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            <dbReference type="DOI" id="10.1038/srep38556"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
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                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
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                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
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        </source>
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    <sequence length="437" mass="49156" checksum="D334486804514036" modified="2017-08-30" version="1">MEFLGVEFSASCGGGLAIINRNWLTPRKKNAFWPPYKTQSVYEKALKTGETPNEANWKIYPVSRCFFETDDYSKARSKLKRAELQSDVQSDADEDSCLSKRAIHPPKRLCYESSDEEGSLSTLPAPPPINISELSKNLLNAESAGSPGRSPHSNPISIKKNRPSKASLIISEHDRQTPAKYNDVTSGCSSSLQSTPYRIRNKLFIPDNLADNLETEDTEICETLNEGQSGPSSVLNSRVSSPNLNHTIVDVDDLLRGTHVDYHDKKYKTLLRLLIHIKSQNDHVAKQNEAILKSLKKREVLQQSNTSYQLPNDVPVKIPIQQLLEIPIIEEYLSEEDHLCAMSAYLSTLGGRDITTKTNTILRSVISNKVAINFSFLGTRNNKQAFTKLNLNKLIIRAVQLSTPNTPEHEINENVKVWLKHAPQRLTLENKKQKENK</sequence>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
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                <person name="Bessho-Uehara M."/>
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                <person name="Debat H.J."/>
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                <person name="Day J.C."/>
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                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
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                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Sander Lower S.E."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
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            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
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                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
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            <dbReference type="PubMed" id="30324905"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
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    <reference evidence="4" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01056944">
        <property type="protein sequence ID" value="JAV72552.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000003">
        <property type="protein sequence ID" value="KAB0801433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1LFW0"/>
    <dbReference type="InParanoid" id="A0A1Y1LFW0"/>
    <dbReference type="OrthoDB" id="10052065at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16442">
        <property type="entry name" value="RING FINGER PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16442:SF1">
        <property type="entry name" value="RING FINGER PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00567">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00333">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50304">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tudor" evidence="2">
        <location>
            <begin position="83"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Tudor" evidence="2">
        <location>
            <begin position="268"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="388"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="JAV72552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0801433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="408" mass="46378" checksum="CC6BE0D270982592" modified="2017-08-30" version="1">MDQQPTCSKYTHFNEEDEKVEETKPLSRYTMYILPKHSVHNVYVSYAGNGPHEIWIQLDSAKQILSVLGEKLSKIPLQTLKYKPKIGTACIVKRYKSTLRSRGMVVDIRANCTYMVLFVDYGNTAYFSWDEMYTIPSRFIQPKVMAMRYTLAESQTLQLTSESLHAFRKFCNNKLLKMLVVEEGTLESLPLCKLRFGNVTAIDILKSNLMLRYLPRAAPDVATDVTISHVNNCGDFYIQEKSSISELRKINAIVQQNCRTAPTIHGSQLSEGLPCCAVSPVDNKWYRTKVLSNINDVVKVSYIDYGDKHTVKLTDLRMPRTNRLTTTCPFALKCSLSGYDDRKDSPANGALYKLIAAREFKMRVVAYKNAVPQVELLDEEGHSVTEELEKELHSLSLGSVPEEDQTEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LKB9</accession>
    <name>A0A1Y1LKB9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histone RNA hairpin-binding protein RNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PPYR_08472</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SLBP family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01058006">
        <property type="protein sequence ID" value="JAV72026.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1LKB9"/>
    <dbReference type="InParanoid" id="A0A1Y1LKB9"/>
    <dbReference type="OrthoDB" id="265795at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071204">
        <property type="term" value="C:histone pre-mRNA 3'end processing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071207">
        <property type="term" value="F:histone pre-mRNA stem-loop binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006398">
        <property type="term" value="P:mRNA 3'-end processing by stem-loop binding and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.1120:FF:000001">
        <property type="entry name" value="Histone RNA hairpin-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1120">
        <property type="entry name" value="Histone RNA hairpin-binding protein RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026502">
        <property type="entry name" value="SLBP1/SLBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029344">
        <property type="entry name" value="SLBP_RNA_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038294">
        <property type="entry name" value="SLBP_RNA_bind_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17408">
        <property type="entry name" value="HISTONE RNA HAIRPIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17408:SF0">
        <property type="entry name" value="HISTONE RNA HAIRPIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15247">
        <property type="entry name" value="SLBP_RNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Histone RNA hairpin-binding protein RNA-binding" evidence="4">
        <location>
            <begin position="162"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="46"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF15247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="JAV72026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0797479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="229" mass="26501" checksum="2AFCB517ED5BFB02" modified="2017-08-30" version="1">MLKRLSMNTSLRDARIFDSEFDDTTTDKCINLMDAFCDNAEFTRIPKVKEEPTEENNSDSGDSLSDFPPPAPNITLKLEPFDADDINFNISQEQLEKIHVKAEFDDNTNSSTNSSSKFGKSEKATIFKREAPYVKREVEPKDSLIATNSSVPKKQKREFENDTAILTRRQKQINYGKNTIGYDNYVKSVPRMDRKPDDPTTPNKYVKYSRRAWDGLIKQWRLKLHKYDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LN93</accession>
    <name>A0A1Y1LN93_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">GOLD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PPYR_02838</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 9">Membrane</location>
            <topology evidence="1 9">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01054794">
        <property type="protein sequence ID" value="JAV73395.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1LN93"/>
    <dbReference type="FunCoup" id="A0A1Y1LN93">
        <property type="interactions" value="2329"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1LN93"/>
    <dbReference type="OrthoDB" id="1929172at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033289744" description="GOLD domain-containing protein" evidence="11">
        <location>
            <begin position="24"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="12">
        <location>
            <begin position="33"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="JAV73395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAB0791038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="204" mass="23351" checksum="58A21085BE4D9744" modified="2017-08-30" version="1">MVHQNWASFAILLVFSLLLPCHSYFITVDAHAEECFFEKVEDGTKMSLHFETAEGGFLDIDVRIVGPDGKVIHSGERETSGRYTFAAHTPGVYTYCFSNKMSTMTPKIVLFNMQIGEQNKHEAQKDGESTTKLEDMIRELSGALTGVKHEQEYMQVRDRIHRSINESTNSRVVLWSIFEALILVAMTVGQVYYLKRFFEVRRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LP72</accession>
    <name>A0A1Y1LP72_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cyclin-H</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PPYR_00231</name>
        <name evidence="11" type="ORF">PPYR_00724</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Associates primarily with CDK7 and MAT1 to form the CAK complex. CAK can further associate with the core-TFIIH to form the TFIIH basal transcription factor.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family. Cyclin C subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01054792">
        <property type="protein sequence ID" value="JAV73396.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1LP72"/>
    <dbReference type="FunCoup" id="A0A1Y1LP72">
        <property type="interactions" value="1866"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1LP72"/>
    <dbReference type="OrthoDB" id="340962at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070985">
        <property type="term" value="C:transcription factor TFIIK complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20524">
        <property type="entry name" value="CYCLIN_CCNH_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20525">
        <property type="entry name" value="CYCLIN_CCNH_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000029">
        <property type="entry name" value="Cyclin h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000088">
        <property type="entry name" value="Cyclin-H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031658">
        <property type="entry name" value="Cyclin_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027081">
        <property type="entry name" value="CyclinH/Ccl1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00569">
        <property type="entry name" value="ccl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16899">
        <property type="entry name" value="Cyclin_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 7" id="KW-0195">Cyclin</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="8">
        <location>
            <begin position="62"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="8">
        <location>
            <begin position="166"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00026042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="JAV73396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0803261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0803754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="328" mass="38154" checksum="4A23F1AE1019DEA9" modified="2017-08-30" version="1">MFATSTQCKHWMFTSEDELNKLRENANFKHIQTYGRQVSEANRYEVFLTPDEEKLMVRKYEYHLRDFCKRFQPPMPRCVVGTAFHYFKRFYINNSVMNYHPKEIMVTCVFLACKVEEFNVSMMQFLANIKGDRDKASDIILNNELLLMQQLNFHLSIHNPFRPVEGLFIDIKTRCTLNDPERLRPGTEHFLERSLLTDAVLLYSPSQVALAAILHAASKLQENLDSYVTDTLFGVEGRGKLDELIDAVRGIRSMVKMVDVAVDKNHQKLLEKKLEKCRNPENNPDSEIYKQRMQAMLYDDDELYTQVVSERQNLDDSTLGMTITSPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LS43</accession>
    <name>A0A1Y1LS43_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myosin-2 essential light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_10503</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01051214">
        <property type="protein sequence ID" value="JAV75085.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01051213">
        <property type="protein sequence ID" value="JAV75087.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01051211">
        <property type="protein sequence ID" value="JAV75090.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1LS43"/>
    <dbReference type="FunCoup" id="A0A1Y1LS43">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1LS43"/>
    <dbReference type="OrthoDB" id="435273at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000082">
        <property type="entry name" value="Myosin light chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000216">
        <property type="entry name" value="Putative calmodulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="76"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00069033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="JAV75090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0796442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="149" mass="17238" checksum="E8D6213F1290F704" modified="2017-08-30" version="1">MARYFKEQDIDEFRECFYLFARSGQIKSLDELTVIMRSLGLSPTISELTSYLKQKQGKMSFADFLEVMHIHSRLEDLPREIVNAFKAADPTGTGVISARQLRHLLQNWGECLSSKEVDRIFREANVTNNSMVRYEDFVKIACAPVPDYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1M063</accession>
    <name>A0A1Y1M063_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PPYR_05497</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GEZM01043277">
        <property type="protein sequence ID" value="JAV79199.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000003">
        <property type="protein sequence ID" value="KAB0801143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1M063"/>
    <dbReference type="InParanoid" id="A0A1Y1M063"/>
    <dbReference type="OrthoDB" id="3437960at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031519">
        <property type="term" value="C:PcG protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000045">
        <property type="entry name" value="ZFP69 zinc finger protein B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000474">
        <property type="entry name" value="zinc finger protein 367"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003:SF26">
        <property type="entry name" value="ZINC FINGER PROTEIN 367"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="78"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="106"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="20"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="22"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="JAV79199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAB0801143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="379" mass="43247" checksum="2227A2B43E20D79F" modified="2017-08-30" version="1">MYRTPKRARIQSENNVVLHDISPSTKSLAGTPNSIDQRPVNGNGNENLVSPSESRRGRPRAEFLNTLILEGTSSPSSIKCTYCGRVFPREKSLQAHLRTHTGERPYVCDYPRCSRRFTQSGQLKTHQRLHTGEKPFMCTAANCDRKFTHANRHCPEHPDAQLRRFTSSLSSSNEKINDEDHSTAVQKWLNNKSSSKPTKRKSMKFSALLENDENESMDAYMKIGDHHKLNLIDSESSQSSKTSLQDFPSYNGDDNISDFEGFSSIQHSNVPPDSVQLYTSHSEVSRTQKSISENIELPKKRWLREAVQDQQRWDASQHLARPINWDEINLVEYENQKRPTVLMRVQDHGTTKEVSRADMQTAIALVELKNGGPLNHRQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1MGF8</accession>
    <name>A0A1Y1MGF8_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PPYR_12501</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the argonaute family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01036123">
        <property type="protein sequence ID" value="JAV82956.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0792881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1MGF8"/>
    <dbReference type="InParanoid" id="A0A1Y1MGF8"/>
    <dbReference type="OrthoDB" id="10252740at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034587">
        <property type="term" value="P:piRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02846">
        <property type="entry name" value="PAZ_argonaute_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04657">
        <property type="entry name" value="Piwi_ago-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014811">
        <property type="entry name" value="ArgoL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032472">
        <property type="entry name" value="ArgoL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032474">
        <property type="entry name" value="Argonaute_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045246">
        <property type="entry name" value="Piwi_ago-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08699">
        <property type="entry name" value="ArgoL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16488">
        <property type="entry name" value="ArgoL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16486">
        <property type="entry name" value="ArgoN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02170">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01163">
        <property type="entry name" value="DUF1785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00949">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50821">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAZ" evidence="3">
        <location>
            <begin position="323"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="Piwi" evidence="4">
        <location>
            <begin position="601"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="76"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
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    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19748">
        <property type="entry name" value="bHLH-O_HEY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000012">
        <property type="entry name" value="hairy/enhancer-of-split related with YRPW motif protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.980">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050370">
        <property type="entry name" value="HES_HEY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003650">
        <property type="entry name" value="Orange_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10985">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07527">
        <property type="entry name" value="Hairy_orange"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00511">
        <property type="entry name" value="ORANGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158457">
        <property type="entry name" value="Orange domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51054">
        <property type="entry name" value="ORANGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0914">Notch signaling pathway</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="11">
        <location>
            <begin position="67"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Orange" evidence="12">
        <location>
            <begin position="145"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="18"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="52"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="JAV87877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAB0801243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="328" mass="36367" checksum="1D32183728574B71" modified="2017-08-30" version="1">MDHSSSHNASMHWNYSAANTTASWTPPSRPVKRPLSESDDCDEIFSEESSKDQCTSPGDTDSCQMLSRKKRRGVIEKKRRDRINTSLSELKRLVPSAFEKQGSSKLEKAEILQMTVDHLKMIHAKGLDALTYDPHKYAMDYHGMGFRECVAEVVRYLERIEGLDMQNPLRLRLTSHLQCCAAQRELATKQATTAGPWSYPATQPYPPLNPLPSPVGPNHGPIGNLGIQQQTTSGLHHQNVHHDLGSFDATTTCSQTSVSPADPSARLAPVTTVLTPLTTSTATSLGYPPHQYTPNSFSVPTTSHHQNYNQNNTQGMKPYRPWGAEVAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1N1Y6</accession>
    <name>A0A1Y1N1Y6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Protoporphyrinogen oxidase</fullName>
            <ecNumber evidence="4 11">1.3.3.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PPYR_05285</name>
        <name evidence="14" type="ORF">PPYR_14978</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>protoporphyrinogen IX + 3 O2 = protoporphyrin IX + 3 H2O2</text>
            <dbReference type="Rhea" id="RHEA:25576"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:57306"/>
            <dbReference type="ChEBI" id="CHEBI:57307"/>
            <dbReference type="EC" id="1.3.3.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="11">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; protoporphyrin-IX from protoporphyrinogen-IX: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the protoporphyrinogen/coproporphyrinogen oxidase family. Protoporphyrinogen oxidase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.3.4" evidence="4 11"/>
    <dbReference type="EMBL" id="GEZM01015027">
        <property type="protein sequence ID" value="JAV91921.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01001006">
        <property type="protein sequence ID" value="KAB0790620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000003">
        <property type="protein sequence ID" value="KAB0800931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1N1Y6"/>
    <dbReference type="FunCoup" id="A0A1Y1N1Y6">
        <property type="interactions" value="1219"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1N1Y6"/>
    <dbReference type="OrthoDB" id="419752at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00324"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004729">
        <property type="term" value="F:oxygen-dependent protoporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000193">
        <property type="entry name" value="Protoporphyrinogen oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004572">
        <property type="entry name" value="Protoporphyrinogen_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050464">
        <property type="entry name" value="Zeta_carotene_desat/Oxidored"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00562">
        <property type="entry name" value="proto_IX_ox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923:SF3">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0274">FAD</keyword>
    <keyword evidence="5 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8 11" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9 11" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="12">
        <location>
            <begin position="10"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="JAV91921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAB0790620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAB0800931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="464" mass="52490" checksum="22971BC19A2403E1" modified="2017-08-30" version="1">MNKVILGGGLSGLSAAYYLRRKFPLQEITLLEGSSRTSGWIKSTKYDDFIFEQGPRTIRPQGVKGINTLKLIEELGLEDDIKFIPRNHPAALNRMIYVNGQLHTLPSSLLRILTKQPPFSKSLLNYLVREVGQPRKFIRSNDESIYDFVYRRFGKEIADYAISPLICGICAGNAKEISVKFLMENLFTHEQKYGSISKGLLYDFFNKSKEKPLLNSLSQRATREKWSVYFFKDGIETLPRRLRKFGEENNVNFMLNKLCTKIEIGNEVSLHTNTGEIIRADYLISSISPKTLGQLIVGHRDLNDLLVSIPCVSVCVVNLHFKNELLEQNGFGFLVPPKENIPILGVIFDSCCTNTKGSTNLTVMMGGYWFEKYFGKNPTRELLLDTALQQLNTILGIKQQPDLYQVSILQDCIPQYVVGHNDTVRKIHDYLQSKKLSLSLCGNSFSGVGINDCIYSAKTTIDNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1N2X9</accession>
    <name>A0A1Y1N2X9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Arf-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_02561</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
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        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
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        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
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        <property type="protein sequence ID" value="JAV92243.1"/>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="18"/>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
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        </source>
    </evidence>
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</entry>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
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                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
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        <text evidence="1">Belongs to the Luc7 family.</text>
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        <source>
            <dbReference type="ARBA" id="ARBA00005655"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="JAV92814.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAB0800180.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="329" mass="39101" checksum="0EA23AAAA4715D1C" modified="2017-08-30" version="1">MTAHDQMRAMLDQLMGTGRNGETNKFHVRFNDPKVCKSFLLSCCPHEILSSTRMDLGECPKIHDLALRADFEKAQSHKDYFYDLDAMEHLQAFISDCDRRTEAAKQRLAETQEELSAEVAVKANNVHELAEQIGQKLAKAEQLGEEGFVEESMKLMEEVDEFRKKKLEAEQEYRNSMPASSYQQQKLRVCEVCSAYLGIHDNDRRLADHFGGKLHLGFIKIREKLIELEATAEKRKEEKRKSMRDRDRDFEREERYRERHREQYVGGRELDRRSKRHRSKSRERNRHTEKDKDRDNRSRPYRSRSRSRDRNRRSHSRHSNSSDKKRDRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1N7G4</accession>
    <name>A0A1Y1N7G4_PHOPY</name>
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        <recommendedName>
            <fullName evidence="17">Pickpocket protein 28</fullName>
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    </protein>
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        <name evidence="15" type="ORF">PPYR_12617</name>
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    <organism evidence="14">
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    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
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                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">1611_PpyrPB1</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">1611_PpyrPB1</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
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    <dbReference type="EMBL" id="GEZM01010814">
        <property type="protein sequence ID" value="JAV93811.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
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        <property type="protein sequence ID" value="KAB0792997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Acid-sensing ion channels like domains"/>
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        <property type="entry name" value="YojJ-like"/>
        <property type="match status" value="1"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AMINACHANNEL"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="4 12" id="KW-0894">Sodium channel</keyword>
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    <keyword evidence="5 12 13" id="KW-0812">Transmembrane</keyword>
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            <end position="102"/>
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    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="527"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="JAV93811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAB0792997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="584" mass="67984" checksum="179DFD71FD7BFA43" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1N8A1</accession>
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        <recommendedName>
            <fullName evidence="8">Solute carrier organic anion transporter family member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PPYR_08040</name>
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    <organism evidence="11">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1 8">Cell membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the organo anion transporter (TC 2.A.60) family.</text>
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    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
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        <property type="protein sequence ID" value="JAV94131.1"/>
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    <dbReference type="EMBL" id="GEZM01010226">
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        <property type="molecule type" value="Transcribed_RNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015347">
        <property type="term" value="F:sodium-independent organic anion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043252">
        <property type="term" value="P:sodium-independent organic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17336">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
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        <property type="entry name" value="OATP"/>
    </dbReference>
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        <property type="entry name" value="oat"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SOLUTE CARRIER ORGANIC ANION TRANSPORTER FAMILY MEMBER 74D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03137">
        <property type="entry name" value="OATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="237"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="275"/>
            <end position="302"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="322"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="423"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="451"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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            <end position="607"/>
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    </feature>
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        <location>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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            <end position="691"/>
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    </feature>
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        <location>
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            <end position="543"/>
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    </feature>
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        <location>
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            <end position="24"/>
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    </feature>
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        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="JAV94132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAB0800160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="724" mass="80403" checksum="28F01776032D495C" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1NC82</accession>
    <name>A0A1Y1NC82_PHOPY</name>
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        <recommendedName>
            <fullName evidence="12">Trafficking kinesin-binding protein milt</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PPYR_11781</name>
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    <organism evidence="9">
        <name type="scientific">Photinus pyralis</name>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
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                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
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            <end position="462"/>
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                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
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                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
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                <person name="Weng J.K."/>
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</entry>
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    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
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                <person name="Bessho-Uehara M."/>
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                <person name="Debat H.J."/>
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                <person name="Stanger-Hall K.F."/>
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                <person name="Schmitz R.J."/>
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                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
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                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
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    <reference evidence="9" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Photinus pyralis genome working group"/>
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                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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        </source>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="PANTHER" id="PTHR21347">
        <property type="entry name" value="CLEFT LIP AND PALATE ASSOCIATED TRANSMEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="LIPID SCRAMBLASE CLPTM1-RELATED"/>
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    <dbReference type="Pfam" id="PF05602">
        <property type="entry name" value="CLPTM1"/>
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    <feature type="transmembrane region" description="Helical" evidence="7">
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                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
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                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
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                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
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                <person name="Sander Lower S.E."/>
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            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the small GTPase superfamily. Ran family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01001577">
        <property type="protein sequence ID" value="JAV97659.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01001576">
        <property type="protein sequence ID" value="JAV97661.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01001575">
        <property type="protein sequence ID" value="JAV97663.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0794656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1NIH5"/>
    <dbReference type="FunCoup" id="A0A1Y1NIH5">
        <property type="interactions" value="1987"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1NIH5"/>
    <dbReference type="OrthoDB" id="48625at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00877">
        <property type="entry name" value="Ran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000131">
        <property type="entry name" value="GTP-binding nuclear protein Ran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002041">
        <property type="entry name" value="Ran_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24071:SF0">
        <property type="entry name" value="GTP-BINDING NUCLEAR PROTEIN RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24071">
        <property type="entry name" value="RAN GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00627">
        <property type="entry name" value="GTPRANTC4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51418">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="JAV97661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0794656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="215" mass="24678" checksum="DE1C4BE489460EAD" modified="2017-08-30" version="1">MTQEPDMPTFKCVLVGDGGTGKTTFVKRHLTGEFEKKYVATLGVEVHPLVFHTNRGPIRFNVWDTAGQEKFGGLRDGYYIQGQCAIIMFDVTSRVTYKNVPNWHRDLVRVCENIPIVLCGNKVDIKDRKVKAKSIVFHRKKNLQYYDVSAKSNYNFEKPFLWLARKLIGDPNLEFVAMVALVPPEVQMDPTWQQQIEKDLKEAQETALPEDDDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N3ZYN7</accession>
    <name>A0A5N3ZYN7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosome biogenesis protein NOP53</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_15484</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NOP53 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01001719">
        <property type="protein sequence ID" value="KAB0790185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N3ZYN7"/>
    <dbReference type="InParanoid" id="A0A5N3ZYN7"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011687">
        <property type="entry name" value="Nop53/GLTSCR2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14211">
        <property type="entry name" value="GLIOMA SUPPRESSOR CANDIDATE REGION GENE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14211:SF7">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN NOP53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07767">
        <property type="entry name" value="Nop53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="35"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="172"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="83"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="55"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="180"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="190"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0790185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="208" mass="24646" checksum="E879609C23C304A1" modified="2020-02-26" version="1">MKDERHLERVTTGMFSKVTESERDNNWLVEMSQGLQKEEAENSDNEYKSINPPVKNKKKDLKQRRKQREHSKLLSAIQMAKKAKKKITDIHNLRNMMQEIKKQTDKAEILKSKRLKKKEYTQLEPKRLARRKFESEEIEFNAPRDISGNLRTVKKEGSILLDRFKSFERRNILRPSSKSNSKKGKFKKFTKSDHKDDWKTTVARPSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N3ZZ49</accession>
    <name>A0A5N3ZZ49_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Fatty acyl-CoA reductase</fullName>
            <ecNumber evidence="10">1.2.1.84</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PPYR_15317</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a long-chain fatty acyl-CoA + 2 NADPH + 2 H(+) = a long-chain primary fatty alcohol + 2 NADP(+) + CoA</text>
            <dbReference type="Rhea" id="RHEA:52716"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:77396"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="EC" id="1.2.1.84"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the fatty acyl-CoA reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.84" evidence="10"/>
    <dbReference type="EMBL" id="VVIM01001458">
        <property type="protein sequence ID" value="KAB0790341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N3ZZ49"/>
    <dbReference type="InParanoid" id="A0A5N3ZZ49"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102965">
        <property type="term" value="F:alcohol-forming long-chain fatty acyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080019">
        <property type="term" value="F:alcohol-forming very long-chain fatty acyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035336">
        <property type="term" value="P:long-chain fatty-acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05236">
        <property type="entry name" value="FAR-N_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09071">
        <property type="entry name" value="FAR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000143">
        <property type="entry name" value="Fatty acyl-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026055">
        <property type="entry name" value="FAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033640">
        <property type="entry name" value="FAR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011:SF60">
        <property type="entry name" value="FATTY ACYL-COA REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011">
        <property type="entry name" value="MALE STERILITY PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03015">
        <property type="entry name" value="Sterile"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0521">NADP</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="481"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="Thioester reductase (TE)" evidence="12">
        <location>
            <begin position="22"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acyl-CoA reductase C-terminal" evidence="11">
        <location>
            <begin position="372"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00052530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAB0790341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="506" mass="58211" checksum="703AB7C4284A0313" modified="2020-02-26" version="1">MSQVERQRSTIEQFFSGGRVFLTGATGFMGKLTLEKLLRSCEGLEKIYVLVRVKKQKNVEDRLEELFQSVVFDRLKVEQPDFKAKVVLIPGDCVQPDLGLNLEDKAMLMEKVNCIFHFAATVRFDQKIRTAAYINVRATRDLLRMANRMLNLKSFVYMSTAYSYCVQKDIGEEFYKPPITGEKLLKLVDSCSDDFLDKITPTLLGDWPNTYAFSKAIAEDVVLNESGGLPLAIVRPSIVIPTAKEPIEGFIDNYYGLTGALLTIAVGLIHVFYAKSDALADTVPADYAINNAIAAAWSVGVEEPKNNGAMDDYRKPPIFNYVSTQDKPLTWRNIMRYCETHFVKYPMKNVLCFYFLTLTSNYYLYITLKLLFHYIPAYIVDFVARLIGKKPFLVDGYRKIGKFMGVIEYFSINQWKFSNDNTQALYRSMSESDKKKFCFDMGTIDWNAFFPIYARGVRVYLAKDPMETLPEAKRWHRKLQVMYHIVICAFWIGLLWTGYCLVKFIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-06-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N3ZZ73</accession>
    <name>A0A5N3ZZ73_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_15267</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01001419">
        <property type="protein sequence ID" value="KAB0790362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N3ZZ73"/>
    <dbReference type="InParanoid" id="A0A5N3ZZ73"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0790362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="152" mass="17073" checksum="6FDAD0CA0290BEE8" modified="2020-02-26" version="1">MKLKVAGKPLEQIVNRLSERDNTNSFQCIDQTFPLVDYKNINDIKVDFGSFVLTKNAPNNCCILKDGGIFEINDIVLHKTSQHNEVHFAGLLYSKKVSLFTSPCDSQEIGICVLCIEEASKVVNITINDVRKKCMFIKLPQSSDILSITLLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N3ZZL4</accession>
    <name>A0A5N3ZZL4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">YqaJ viral recombinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_15090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01001176">
        <property type="protein sequence ID" value="KAB0790511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N3ZZL4"/>
    <dbReference type="InParanoid" id="A0A5N3ZZL4"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd22343">
        <property type="entry name" value="PDDEXK_lambda_exonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051703">
        <property type="entry name" value="NF-kappa-B_Signaling_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019080">
        <property type="entry name" value="YqaJ_viral_recombinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46609">
        <property type="entry name" value="EXONUCLEASE, PHAGE-TYPE/RECB, C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46609:SF8">
        <property type="entry name" value="YQAJ VIRAL RECOMBINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09588">
        <property type="entry name" value="YqaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YqaJ viral recombinase" evidence="1">
        <location>
            <begin position="78"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0790511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="275" mass="32211" checksum="51AACE9BEA9CE4DA" modified="2020-02-26" version="1" fragment="single">AGRRCTNLSTFENEEVFTPYDEHDVVILNHATQSILMMELYHFHVNFIGSCCKELFDKHLLKDIDEILLKTKQSKEFWNIERKFRVTGSRIYELYTYKSDDWQKKANRYFNPISFMNKFTKHGIEQEPVARQIFMDATGLKVVECGLVVSHFNSWLGYSPDGIIVDQDGNPKELIEIKCPFAGATETIGSVVPKLKYLQLEDNIYELKKKHKYFAQVQLGMAMLNVFNCKFIIYCSFDKSMLILDVPYNYDFSKTLLFNVKGKYFKKMLHVMCNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N3ZZN0</accession>
    <name>A0A5N3ZZN0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HECT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_15074</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01001156">
        <property type="protein sequence ID" value="KAB0790525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N3ZZN0"/>
    <dbReference type="InParanoid" id="A0A5N3ZZN0"/>
    <dbReference type="OrthoDB" id="6780967at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="4">
        <location>
            <begin position="352"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="191"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0790525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="673" mass="76559" checksum="03A052D996398943" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A0C3</accession>
    <name>A0A5N4A0C3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PiggyBac transposable element-derived protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_15415</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000771">
        <property type="protein sequence ID" value="KAB0790775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A0C3"/>
    <dbReference type="FunCoup" id="A0A5N4A0C3">
        <property type="interactions" value="50"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A0C3"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47272">
        <property type="entry name" value="DDE_TNP_1_7 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47272:SF2">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 3-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="2">
        <location>
            <begin position="35"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="423"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0790775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="508" mass="58747" checksum="51F446BC12A9C92E" modified="2020-02-26" version="1">MDNKRKWVNSDSMYGPGTLPPFLGLEGGKTQSKRPIDYFLFYFSDEILEEIVFQSNLYAHQLDKPNFTLTKYELQTFLGINLIMSYIRYPRTRLYWNSDAAFRMSFIADSMPVNRYESILRHLHFTNNLDLDTNSTDKLKKLRPFLDKLQKNFLSATEPEEYQAINEQIVPLKGRLSIKQYLPKKPKKWGVKIWVRAGVSGYMYRFEVYQGAGGGREAISDFGACGDVILRLSDDIQHKNHKLFFDNLFCSVPLLQELKQRKIWATGTLRGNRLSGAGECLMSEKDMKKQGRGTSSVVSTESGDITITKWMDSNAIHIGSTCAGVEPQSSVKRWSKPNKTTIEVNRPFSVKYYNKNMGGVDLLDQLLALYPLRRRNKRWYIRIFMHFLDVAVINSWILYKKDGNSDMDLLEFKGSVGRTLINRGTRNSENKRGRPRSTTPPTSILKTRKPNHHAPEEIRKDNFGHWPKLTDIKNARRCHSSSCKRKTKDICKRCNEPCCPDCMENFHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A0X7</accession>
    <name>A0A5N4A0X7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UDP-glucuronosyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PPYR_02772</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:132367"/>
            <dbReference type="ChEBI" id="CHEBI:132368"/>
            <dbReference type="EC" id="2.4.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Membrane</location>
            <topology evidence="5">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.17" evidence="5"/>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0790972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A0X7"/>
    <dbReference type="InParanoid" id="A0A5N4A0X7"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015020">
        <property type="term" value="F:glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000050">
        <property type="entry name" value="UDP-glucuronosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035595">
        <property type="entry name" value="UDP_glycos_trans_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF159">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00375">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="475"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0790972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="520" mass="59038" checksum="4B367E8F6367CE22" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-06-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A131</accession>
    <name>A0A5N4A131_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_02837</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A131"/>
    <dbReference type="InParanoid" id="A0A5N4A131"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0791037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="217" mass="25529" checksum="FA333CE28FC37645" modified="2020-02-26" version="1">MENINDVIFDDELFEVLQADIARSQQDRIQQRRREERERFVQTLKNAQSDLVIELENLTAISFEEKLSKLHDLINVPLNGSTLLRITENCITNVGLSKFSNKEDCVDINIPDSCESKLIKLQSAKDLLDAERTRIITSMECNERCGFRYLKELLLLLRRVTEYLELLEDDEYPTRDYVQYTHYAAMDVCIRIGKYKSEIEEDDEAFNNLLQKYNQFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A1A0</accession>
    <name>A0A5N4A1A0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MABP1/WDR62 second WD40 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_02904</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A1A0"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007099">
        <property type="term" value="P:centriole replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056162">
        <property type="entry name" value="WD40_MABP1-WDR62_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052779">
        <property type="entry name" value="WDR62"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45589">
        <property type="entry name" value="WD REPEAT DOMAIN 62, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45589:SF1">
        <property type="entry name" value="WD REPEAT DOMAIN 62, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24782">
        <property type="entry name" value="WD40_MABP1-WDR62_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="MABP1/WDR62 second WD40" evidence="3">
        <location>
            <begin position="344"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="652"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="793"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="846"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="904"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1060"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1189"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="793"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="855"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1075"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1119"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1161"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1214"/>
            <end position="1223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0791104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1397" mass="155482" checksum="A904252AF81EDA51" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A1Q0</accession>
    <name>A0A5N4A1Q0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">LTD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PPYR_03026</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus lamina</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the intermediate filament family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="OrthoDB" id="102442at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005638">
        <property type="term" value="C:lamin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007112">
        <property type="term" value="P:male meiosis cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="GO" id="GO:0006998">
        <property type="term" value="P:nuclear envelope organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007097">
        <property type="term" value="P:nuclear migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051664">
        <property type="term" value="P:nuclear pore localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090435">
        <property type="term" value="P:protein localization to nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="Intermediate filament protein B"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Lamin Tail domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.500">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1160">
        <property type="entry name" value="Vasodilator-stimulated phosphoprotein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018039">
        <property type="entry name" value="IF_conserved"/>
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        <property type="entry name" value="IF_rod_dom"/>
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    <dbReference type="InterPro" id="IPR001322">
        <property type="entry name" value="Lamin_tail_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036415">
        <property type="entry name" value="Lamin_tail_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45721">
        <property type="entry name" value="LAMIN DM0-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45721:SF11">
        <property type="entry name" value="LAMIN DM0-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Filament"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00932">
        <property type="entry name" value="LTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01391">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64593">
        <property type="entry name" value="Intermediate filament protein, coiled coil region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74853">
        <property type="entry name" value="Lamin A/C globular tail domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00226">
        <property type="entry name" value="IF_ROD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51842">
        <property type="entry name" value="IF_ROD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51841">
        <property type="entry name" value="LTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 5" id="KW-0403">Intermediate filament</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IF rod" evidence="9">
        <location>
            <begin position="32"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="LTD" evidence="8">
        <location>
            <begin position="432"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="399"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="564"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="29"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="135"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="250"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="8"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="567"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0791226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="585" mass="67260" checksum="9506B660A65814FD" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A409</accession>
    <name>A0A5N4A409_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SHSP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_14002</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A409"/>
    <dbReference type="InParanoid" id="A0A5N4A409"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06526">
        <property type="entry name" value="metazoan_ACD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001436">
        <property type="entry name" value="Alpha-crystallin/sHSP_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45640:SF13">
        <property type="entry name" value="HEAT SHOCK PROTEIN 22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45640">
        <property type="entry name" value="HEAT SHOCK PROTEIN HSP-12.2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00299">
        <property type="entry name" value="ACRYSTALLIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="4">
        <location>
            <begin position="41"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="SHSP" evidence="4">
        <location>
            <begin position="159"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0792041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="274" mass="31036" checksum="34972D8C0A6B7E36" modified="2020-02-26" version="1">MSLLPLLFRDVARPLRMMDHQMRLDEELFPFLVYRTIPRGRNPLEVGDGKESVTQDRDKFQVKLDVENFSPEEITIKAIDGNAIVVEAKHEKSDENGHICRQFYRKFVIPKGHDMKKVESVLSADGIPTITAPNKVEQVEERAIPITHVDTSEAIPRGRNPLEAGDGKESVIQDRDKFQVKLDVENFSPEEITIKAIDGNAIVVEAKHEKSDENGHICRQFYRKFVIPKGHDMKKVESVLSADGIPTITAPNKVEQVEERAIPITHVDTREGNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A4F0</accession>
    <name>A0A5N4A4F0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PPYR_14152</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A4F0"/>
    <dbReference type="FunCoup" id="A0A5N4A4F0">
        <property type="interactions" value="257"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A4F0"/>
    <dbReference type="OrthoDB" id="2417221at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005689">
        <property type="term" value="C:U12-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013085">
        <property type="entry name" value="U1-CZ_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16465">
        <property type="entry name" value="NUCLEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16465:SF0">
        <property type="entry name" value="ZINC FINGER MATRIN-TYPE PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06220">
        <property type="entry name" value="zf-U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="5">
        <location>
            <begin position="51"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="51"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0792193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="169" mass="20343" checksum="12C6CF7549ED2D34" modified="2020-02-26" version="1">MGWRYYCDYCDKTFKDDLEARKKHLTSSLHIKLRKLHYEQHRDPRAILADESTKTSCRRYIQHGECQFAGNCKYTHYSSEDLWKLKQRIAMEDYEAACRTQEMPEVATLESWVEKYNREHSKTIKTRPDSVEVHWSYPEYLECRTDLPPSLKKFKPKDFKDCQFGEWGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-06-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A4U3</accession>
    <name>A0A5N4A4U3_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_14305</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A4U3"/>
    <dbReference type="InParanoid" id="A0A5N4A4U3"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0792346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="52" mass="5782" checksum="6E61335EB9013F58" modified="2020-02-26" version="1" fragment="single">CASVIQSACEHSKKLESQFMESEHVLDISVNDVIIDLGEDDSNESDFCFSDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A5A8</accession>
    <name>A0A5N4A5A8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Chitin-binding type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_14483</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A5A8"/>
    <dbReference type="InParanoid" id="A0A5N4A5A8"/>
    <dbReference type="OrthoDB" id="10059269at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052976">
        <property type="entry name" value="Scoloptoxin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22933">
        <property type="entry name" value="FI18007P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22933:SF42">
        <property type="entry name" value="FI18455P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024274914" description="Chitin-binding type-2 domain-containing protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="2">
        <location>
            <begin position="65"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0792524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="158" mass="17823" checksum="8E9A4BE10B135876" modified="2020-02-26" version="1">MSAVLILCLLSWFVNAGAVYEEFTHHVAVPLKLRQAEKEQLQDLSKIPGVPGVDYPIYHSVPETGFSCHNVPALPGMYANVETGCQAYHVCHDGREGHQGASFLCTNGTIFNQEEFACDWWYNVNCHNAINLYRVNLDPHKNPYFPKVKTEESLPVHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A5M4</accession>
    <name>A0A5N4A5M4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Caspase family p20 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_14584</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase C14A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A5M4"/>
    <dbReference type="InParanoid" id="A0A5N4A5M4"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043525">
        <property type="term" value="P:positive regulation of neuron apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00032">
        <property type="entry name" value="CASc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033139">
        <property type="entry name" value="Caspase_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016129">
        <property type="entry name" value="Caspase_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002398">
        <property type="entry name" value="Pept_C14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002138">
        <property type="entry name" value="Pept_C14_p10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001309">
        <property type="entry name" value="Pept_C14_p20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015917">
        <property type="entry name" value="Pept_C14A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10454:SF232">
        <property type="entry name" value="AT03047P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10454">
        <property type="entry name" value="CASPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00376">
        <property type="entry name" value="IL1BCENZYME"/>
    </dbReference>
    <dbReference type="SMART" id="SM00115">
        <property type="entry name" value="CASc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01122">
        <property type="entry name" value="CASPASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01121">
        <property type="entry name" value="CASPASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50207">
        <property type="entry name" value="CASPASE_P10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50208">
        <property type="entry name" value="CASPASE_P20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Caspase family p20" evidence="8">
        <location>
            <begin position="5"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Caspase family p10" evidence="7">
        <location>
            <begin position="160"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0792625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="237" mass="26676" checksum="1464C7605F6296BA" modified="2020-02-26" version="1">MNHYRRGHAIIFSHIQFDGDLAKREGASKDAKDLEEVLVALKFNVKVYTDLKYGAIYEVITTCKYTSPMVSDDVVVFVVSQSDHSDVDCLLVAVLSHGDRGKVYARDHQYPPDFLWKSFSGDKCPSLAGKPKLFFVQACRGDETDDGSRVRMATQVDSQASYTIPVMADILVMYSCYDGYVSWRSTRTGSWFIQSLCEELKTRSKSTDLLTILTFLNRRMAITYKSVAPKSQIGSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A742</accession>
    <name>A0A5N4A742_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PPYR_12753</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A742"/>
    <dbReference type="InParanoid" id="A0A5N4A742"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015280">
        <property type="term" value="F:ligand-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.820">
        <property type="entry name" value="Acid-sensing ion channel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.770">
        <property type="entry name" value="YojJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020903">
        <property type="entry name" value="ENaC_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF288">
        <property type="entry name" value="AMILORIDE-SENSITIVE NA+ CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01078">
        <property type="entry name" value="AMINACHANNEL"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01206">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="4 12" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="10 12" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="231"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAB0793133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="287" mass="32954" checksum="F424AE68E1A48648" modified="2020-02-26" version="1">MKTKGRHSRDDYPRRTFVPGARGGLTIDSLYTNKNHIDPLCEGSIQGYKVALHHPSEMPNMDRCFLLPLDQVVFVGIKPSLISVSPELVNYAPRVRNCYFTHERYLASYKGYTQQNCMEECLANYTMKRCKCIPFFFPPLHDKINICGPGSSECVREMKYLEVEPCECLPSCTSVSYDVETSQTNWLWNDVLEASHPLERLIYNELLKDVYYKDAQFLTCERKELHGLVDFFSNVGGLFGLFIGFSVTSVFEILYFLTLRIICNIKKYGKDAWSGDPCVISKQPLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A833</accession>
    <name>A0A5N4A833_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PPYR_13085</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SINA (Seven in absentia) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A833"/>
    <dbReference type="InParanoid" id="A0A5N4A833"/>
    <dbReference type="OrthoDB" id="6704469at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000041">
        <property type="entry name" value="E3 ubiquitin-protein ligase SINAT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004162">
        <property type="entry name" value="SINA-like_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013010">
        <property type="entry name" value="Znf_SIAH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45877">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SIAH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45877:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SINA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21361">
        <property type="entry name" value="Sina_ZnF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51081">
        <property type="entry name" value="ZF_SIAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SIAH-type" evidence="11">
        <location>
            <begin position="61"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAB0793465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="472" mass="53748" checksum="59B59BF76A52E516" modified="2020-02-26" version="1">MYEKIQKVPNSALEHLQCALCKRYLSCSPLSVMTDGGTRCGRCSGEEGCIRVFALEVILARFAFPCIFKESGCKQTVMYNEAIQHEAKCDFRSLLCPFSSHDCNWKDSREQLLSHITESHHNRIKNSSITLELGQNSSDTFATIKEKALFIIGFVYDSTESILRYDVRYCANEATDSSVRIQLLNYVDRDCSINLKATNCHNFDETFSEPQNDSTLNINNYLSNLENPPTIVVNLSLTQSLPLPHISGGDFLNSLKCSECFNYLIPPIFDLDEQLICADCGRTNPRCVPSENEDIKRLVADVHYPCRWRECATVVKSDQLKLHELHCVHRSFDCFFPTCRKGFRLDSAIDHLLSHRAIFMPIGIEYTHKFAHTYNFKHLFTIREGVIVVIQHSNVKSEEANLHRVALFSSNPTPVTATIDFEHSHCKIKSKLFLLVSDHNTEVSLDQLPPCFKDSDELKVALNVDELEEPNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A858</accession>
    <name>A0A5N4A858_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glycosyltransferase family 92 protein</fullName>
            <ecNumber evidence="8">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_13136</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyltransferase 92 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="8"/>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A858"/>
    <dbReference type="FunCoup" id="A0A5N4A858">
        <property type="interactions" value="110"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A858"/>
    <dbReference type="OrthoDB" id="2017643at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008166">
        <property type="entry name" value="Glyco_transf_92"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21461">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21461:SF83">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01697">
        <property type="entry name" value="Glyco_transf_92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0793516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="552" mass="64497" checksum="136970296BA501EF" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A880</accession>
    <name>A0A5N4A880_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nitrogen permease regulator 2-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_13140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NPR2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A880"/>
    <dbReference type="FunCoup" id="A0A5N4A880">
        <property type="interactions" value="712"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A880"/>
    <dbReference type="OrthoDB" id="338854at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990130">
        <property type="term" value="C:GATOR1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009348">
        <property type="entry name" value="NPR2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12991:SF10">
        <property type="entry name" value="GATOR COMPLEX PROTEIN NPRL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12991">
        <property type="entry name" value="NITROGEN PERMEASE REGULATOR 2/TUMOR SUPPRESSOR CANDIDATE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06218">
        <property type="entry name" value="NPR2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0793520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="397" mass="44776" checksum="6A84ECC335E0BA29" modified="2020-02-26" version="1">MFVNKQIKCFTMGEDNIPAADNAYKQECPIRCIFLCEFHPTAGPIISCQVPENFISKELFDSVSVYIITKPELLRSTITVTLTDYKILGCPVRIDDKKYARNAFYFNLCFVCDSSARTVHYEPLVTKLSDYLMALEMESNFLSTGSAPSQLVPLLKQVLEDLNTKGECALIGGPTATHLKVVHVRSAPPPVADHQVPIFLKHLPTQEWDLTTQQVAPFINGFNHIARIAALADVENNLVKACVQNLVYYGAVALVPLFQYGNVYCTTPKLKLLVQNQVLQRKCLHYVANSSRQLPNIRDVFRMYAAMTRGTTIRDLCVRFNPACLNINERKLVQFGILEELIRRVNKYPVYVGDNHELQKSFSGGASLDEICCVAGINVQQLEDQLERDHNVVILWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AA27</accession>
    <name>A0A5N4AA27_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Peptidase metallopeptidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PPYR_13728</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">1611_PpyrPB1</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="12">Can bind about 5 Ca(2+) ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M10A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0794108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AA27"/>
    <dbReference type="FunCoup" id="A0A5N4AA27">
        <property type="interactions" value="232"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AA27"/>
    <dbReference type="OrthoDB" id="406838at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030574">
        <property type="term" value="P:collagen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00094">
        <property type="entry name" value="HX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04278">
        <property type="entry name" value="ZnMc_MMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.110.10.10:FF:000018">
        <property type="entry name" value="Matrix metallopeptidase 25b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000022">
        <property type="entry name" value="Matrix metalloproteinase 1, isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.110.10.10">
        <property type="entry name" value="Hemopexin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000585">
        <property type="entry name" value="Hemopexin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036375">
        <property type="entry name" value="Hemopexin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018487">
        <property type="entry name" value="Hemopexin-like_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033739">
        <property type="entry name" value="M10A_MMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001818">
        <property type="entry name" value="Pept_M10_metallopeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021190">
        <property type="entry name" value="Pept_M10A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021158">
        <property type="entry name" value="Pept_M10A_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201">
        <property type="entry name" value="MATRIX METALLOPROTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201:SF308">
        <property type="entry name" value="MATRIX METALLOPROTEINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00045">
        <property type="entry name" value="Hemopexin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00413">
        <property type="entry name" value="Peptidase_M10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001191">
        <property type="entry name" value="Peptidase_M10A_matrix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00138">
        <property type="entry name" value="MATRIXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00120">
        <property type="entry name" value="HX"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50923">
        <property type="entry name" value="Hemopexin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="PGBD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00546">
        <property type="entry name" value="CYSTEINE_SWITCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51642">
        <property type="entry name" value="HEMOPEXIN_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="7 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Peptidase metallopeptidase" evidence="16">
        <location>
            <begin position="131"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="14">
        <location>
            <begin position="444"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="14">
        <location>
            <begin position="496"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="14">
        <location>
            <begin position="543"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="14">
        <location>
            <begin position="591"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="301"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="308"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="341"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="357"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="403"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="250"/>
        </location>
    </feature>
    <feature type="binding site" description="in inhibited form" evidence="12">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="452"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="454"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>5</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="500"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="549"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>5</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="595"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="597"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>5</label>
        </ligand>
    </feature>
    <feature type="modified residue" description="Phosphotyrosine; by PKDCC" evidence="13">
        <location>
            <position position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001191-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001191-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR621190-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR621190-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAB0794108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="684" mass="79446" checksum="650F3C72BB959129" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-06-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AAK2</accession>
    <name>A0A5N4AAK2_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_11191</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0794352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AAK2"/>
    <dbReference type="InParanoid" id="A0A5N4AAK2"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="entry name" value="Intergrase catalytic core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0794352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="70" mass="8149" checksum="AD1D441DB879E33A" modified="2020-02-26" version="1" fragment="single">VVAIFGLFGACRRIEFYNLCVSDVQEEGAVFVVNLKDTKTHRPRTFTILNDDSMNYTELIKKYINLRPKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AC78</accession>
    <name>A0A5N4AC78_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytoplasmic tRNA 2-thiolation protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_11776</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6/CTU1 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CTU2/NCS2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0794937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AC78"/>
    <dbReference type="FunCoup" id="A0A5N4AC78">
        <property type="interactions" value="1695"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AC78"/>
    <dbReference type="OrthoDB" id="25129at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032447">
        <property type="term" value="P:protein urmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03054">
        <property type="entry name" value="CTU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019407">
        <property type="entry name" value="CTU2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20882">
        <property type="entry name" value="CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20882:SF14">
        <property type="entry name" value="CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10288">
        <property type="entry name" value="CTU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0794937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="403" mass="46066" checksum="FF673527DEECB88F" modified="2020-02-26" version="1">MCSVGDDVDEEKAKFMQKKITLNFTNALCIKCRTLKPQVILHNQYPYCKACFLSGTVHKFKALLGKNRVVQPNESVLIHHKAGHASTALLHFLRTGLDLNTPKKIRFKPIIAYIEDNYELNVEDRTHISRQVSDEAERLNFPIVFINLAQYVTNKSNLPSIVHEKVEDLRIDPDDNMKIRAAVKSNSTLTTQTEIVHYFERELLLKVAKHLGCQCIFTTDLGIDIASQLLKNVTLGRGENIVYDTGVVDSRDMDVSVLRPLRNFTIKELALYNYFNHLEPVSFYRKTKNPYSSMQNLVEKFLADLHVNYPATISTIVRTGDKLGVNNEPSEDRCMLCKVPIRKEIESLGSAEATNFSHWISTQTRSCDKSLKERTSQILATFDNNKYNKYCYSCNQIAPYLCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ADV6</accession>
    <name>A0A5N4ADV6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mitochondrial Rho GTPase</fullName>
            <ecNumber evidence="14">3.6.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PPYR_12344</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">1611_PpyrPB1</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Mitochondrion outer membrane</location>
            <topology evidence="1 14">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the mitochondrial Rho GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="14"/>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0795505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ADV6"/>
    <dbReference type="FunCoup" id="A0A5N4ADV6">
        <property type="interactions" value="1461"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4ADV6"/>
    <dbReference type="OrthoDB" id="10020961at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01893">
        <property type="entry name" value="Miro1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01892">
        <property type="entry name" value="Miro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000011">
        <property type="entry name" value="Mitochondrial Rho GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000170">
        <property type="entry name" value="Mitochondrial Rho GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001271">
        <property type="entry name" value="Mitochondrial Rho GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013566">
        <property type="entry name" value="EF_hand_assoc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013567">
        <property type="entry name" value="EF_hand_assoc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021181">
        <property type="entry name" value="Miro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052266">
        <property type="entry name" value="Miro-EF-hand_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020860">
        <property type="entry name" value="MIRO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46819">
        <property type="entry name" value="EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46819:SF1">
        <property type="entry name" value="EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08355">
        <property type="entry name" value="EF_assoc_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08356">
        <property type="entry name" value="EF_assoc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037488">
        <property type="entry name" value="Mt_Rho_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51423">
        <property type="entry name" value="MIRO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0106">Calcium</keyword>
    <keyword evidence="12 14" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13 14 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 14" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="6 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="636"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="domain" description="Miro" evidence="17">
        <location>
            <begin position="8"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="16">
        <location>
            <begin position="309"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="Miro" evidence="17">
        <location>
            <begin position="420"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR037488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAB0795505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="666" mass="76191" checksum="92E8D97102CCBF4D" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AE42</accession>
    <name>A0A5N4AE42_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Calponin-homology (CH) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PPYR_12425</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">1611_PpyrPB1</strain>
            <tissue evidence="19">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Myofibril</location>
            <location evidence="2">Sarcomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the nesprin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0795586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A5N4AE42">
        <property type="interactions" value="337"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AE42"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034993">
        <property type="term" value="C:meiotic nuclear membrane microtubule tethering complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005640">
        <property type="term" value="C:nuclear outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030017">
        <property type="term" value="C:sarcomere"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007097">
        <property type="term" value="P:nuclear migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006997">
        <property type="term" value="P:nucleus organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd21241">
        <property type="entry name" value="CH_SYNE1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21243">
        <property type="entry name" value="CH_SYNE1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00176">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000033">
        <property type="entry name" value="nesprin-1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000037">
        <property type="entry name" value="nesprin-1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000186">
        <property type="entry name" value="nesprin-1 isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000171">
        <property type="entry name" value="Uncharacterized protein, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000195">
        <property type="entry name" value="Uncharacterized protein, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000188">
        <property type="entry name" value="Uncharacterized protein, isoform D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000219">
        <property type="entry name" value="Uncharacterized protein, isoform J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="36"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001589">
        <property type="entry name" value="Actinin_actin-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047290">
        <property type="entry name" value="CH_SYNE1_rpt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047291">
        <property type="entry name" value="CH_SYNE1_rpt2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012315">
        <property type="entry name" value="KASH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052403">
        <property type="entry name" value="LINC-complex_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018159">
        <property type="entry name" value="Spectrin/alpha-actinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002017">
        <property type="entry name" value="Spectrin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057057">
        <property type="entry name" value="Spectrin_SYNE1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47535">
        <property type="entry name" value="MUSCLE-SPECIFIC PROTEIN 300 KDA, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47535:SF1">
        <property type="entry name" value="NESPRIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10541">
        <property type="entry name" value="KASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00435">
        <property type="entry name" value="Spectrin"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25034">
        <property type="entry name" value="Spectrin_SYNE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01249">
        <property type="entry name" value="KASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00150">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="49"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="52"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00019">
        <property type="entry name" value="ACTININ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00020">
        <property type="entry name" value="ACTININ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51049">
        <property type="entry name" value="KASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="9 15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="topological domain" description="Cytoplasmic" evidence="14">
        <location>
            <begin position="1"/>
            <end position="15043"/>
        </location>
    </feature>
    <feature type="topological domain" description="Perinuclear space" evidence="14">
        <location>
            <begin position="15065"/>
            <end position="15094"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="17">
        <location>
            <begin position="253"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="17">
        <location>
            <begin position="396"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="KASH" evidence="18">
        <location>
            <begin position="15035"/>
            <end position="15094"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="134"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="8001"/>
            <end position="8059"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="8097"/>
            <end position="8139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="8188"/>
            <end position="8207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="8243"/>
            <end position="8265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="8445"/>
            <end position="8471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="8484"/>
            <end position="8616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="8628"/>
            <end position="8707"/>
        </location>
    </feature>
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<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
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        <name evidence="2" type="ORF">PPYR_09826</name>
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        <name type="scientific">Photinus pyralis</name>
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        <name type="synonym">Lampyris pyralis</name>
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            <taxon>Arthropoda</taxon>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
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            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
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        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </evidence>
    <sequence length="118" mass="13333" checksum="4231430A0BBC69A0" modified="2020-02-26" version="1">MDKFLGKKHNIQPVAVASSLQGDSTPCSSDSEQALEDTGPPAKKIRSSISKNVKERKSQGLMEELRQSAQAREVNRERRHQELLNIRTKAVNIFSTKMDELIKSINKNDKDKQNNVDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AJ05</accession>
    <name>A0A5N4AJ05_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PPYR_08273</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the muscleblind family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AJ05"/>
    <dbReference type="InParanoid" id="A0A5N4AJ05"/>
    <dbReference type="OrthoDB" id="6285980at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043484">
        <property type="term" value="P:regulation of RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054429">
        <property type="entry name" value="Znf-CCCH_Muscleblind-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12675">
        <property type="entry name" value="MUSCLEBLIND-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12675:SF12">
        <property type="entry name" value="PROTEIN MUSCLEBLIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22628">
        <property type="entry name" value="zf-CCCH_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="39"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="73"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="6">
        <location>
            <begin position="39"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="6">
        <location>
            <begin position="73"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0797279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="124" mass="13344" checksum="0DFC8711C00CC6E3" modified="2020-02-26" version="1">MTLACCTAGRCMSPALDNGPPVPSNAPFVIYTDDHGQLLDTLQVCQDFNRGLCNRPACKFVHIQDGDGVEVVDQRVAVCRDAATGKCSRSVCKYYHIPIALPPAPIMAALASTLQQSQRHSPNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AJE3</accession>
    <name>A0A5N4AJE3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Homeotic protein spalt-major</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PPYR_08407</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">1611_PpyrPB1</strain>
            <tissue evidence="19">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Required for the establishment of the posterior-most head and the anterior-most tail segments of the embryo. Probably function as a transcriptional regulator. Could repress the transcription of the tsh gene.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the sal C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A5N4AJE3">
        <property type="interactions" value="291"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AJE3"/>
    <dbReference type="OrthoDB" id="8749569at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035107">
        <property type="term" value="P:appendage morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002027">
        <property type="entry name" value="Blast:Sal-like protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000708">
        <property type="entry name" value="Sal-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000025">
        <property type="entry name" value="Spalt-like transcription factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000341">
        <property type="entry name" value="Spalt-like transcription factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000215">
        <property type="entry name" value="Spalt-like transcription factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000130">
        <property type="entry name" value="Spalt-like transcription factor 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000291">
        <property type="entry name" value="Spalt-like transcription factor 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000193">
        <property type="entry name" value="Zinc finger protein 300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051565">
        <property type="entry name" value="Sal_C2H2-zinc-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23233:SF84">
        <property type="entry name" value="FI23031P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23233">
        <property type="entry name" value="SAL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="385"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="413"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="738"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="766"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="798"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="1076"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="1104"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="1224"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="1252"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="119"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="223"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="466"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="537"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="888"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="949"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1142"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1394"/>
            <end position="1445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="229"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="286"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="552"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="637"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="661"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="890"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="922"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="964"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="993"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="1167"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="1412"/>
            <end position="1435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00056983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00071947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAB0797413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1445" mass="159125" checksum="C5E2D3CA39D93128" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AJU2</accession>
    <name>A0A5N4AJU2_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_08572</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AJU2"/>
    <dbReference type="FunCoup" id="A0A5N4AJU2">
        <property type="interactions" value="15"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AJU2"/>
    <dbReference type="OrthoDB" id="6601693at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23992">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.20">
        <property type="entry name" value="Pheromone/general odorant binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006170">
        <property type="entry name" value="PBP/GOBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036728">
        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01395">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024467883" evidence="1">
        <location>
            <begin position="29"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0797579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="146" mass="16847" checksum="A1D9E72CAFC24714" modified="2020-02-26" version="1">MKSFIVHSLRSSANLLIILCFIMSSVELKLRPDVIVHWENYHIRYFDTCVKETGVDPMIPRTMLRQINLPDEESFHCYLKCIFQYNHMLTPDGKDIDYDAFGADIHVTPEVLKVCRELGGTESEICRKTYLVAKCTIDDKVNSSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AK08</accession>
    <name>A0A5N4AK08_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SIAH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PPYR_08654</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AK08"/>
    <dbReference type="InParanoid" id="A0A5N4AK08"/>
    <dbReference type="OrthoDB" id="6772184at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004162">
        <property type="entry name" value="SINA-like_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013010">
        <property type="entry name" value="Znf_SIAH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45877">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SIAH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45877:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SINA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21361">
        <property type="entry name" value="Sina_ZnF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51081">
        <property type="entry name" value="ZF_SIAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SIAH-type" evidence="5">
        <location>
            <begin position="53"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0797661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="493" mass="56897" checksum="7423AF0F836A10B0" modified="2020-02-26" version="1">MKLQTLLYARHAKGTYHVAQSVKELNGNFICGRCHETEPNAVSQLCYERMMSNFTFPCRYDKEGCTDRLRFNSSLEHERKCQYRPIVCPSVLKKACTQSIPACQLYTHFIEAHKDLISNDGQFKIHLDEKTRYNALMLHDDNTVVVKYLYDDVERRLHLEVAYVSSDEDSLYYQLQLINGTNYDNSLSLSQQACTLYETQGITSTNCAVIDLEMYLAVLENPPSLILKISLTSLVEYSTRSGSEMQTLQLKALRHSSNEKEEQSEPSEAFVNLENFLCHACKSITSTPMYHPSEDISLQYCESCREDDMIQSYEVNGNDNYPCRWRGCTFLGDINSVFDHIKTCTFKKYICPFYTSCEKMSFKHNQFEAFIKHLKLHSTYCPNPESITIQLFDRNSSPSDYVEKSYFTGVGNEAVVFKCAIEPHKCNWTLRCVLPDKIEATVFFRHDHCRFTSKVFTYDTQRLVDLSKGGIDFPLCFTEYPCLTAVISLRNTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2024-07-24" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AKA9</accession>
    <name>A0A5N4AKA9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Peptidase M13 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PPYR_08750</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AKA9"/>
    <dbReference type="InParanoid" id="A0A5N4AKA9"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08662">
        <property type="entry name" value="M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF224">
        <property type="entry name" value="NEPRILYSIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00786">
        <property type="entry name" value="NEPRILYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="10">
        <location>
            <begin position="83"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="9">
        <location>
            <begin position="519"/>
            <end position="724"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0797757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="725" mass="83254" checksum="C2A7CAF6D18050BA" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AKF3</accession>
    <name>A0A5N4AKF3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">VPS37 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PPYR_08813</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Late endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS37 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AKF3"/>
    <dbReference type="FunCoup" id="A0A5N4AKF3">
        <property type="interactions" value="117"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AKF3"/>
    <dbReference type="OrthoDB" id="10260857at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043162">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11685">
        <property type="entry name" value="UEV_TSG101-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.660">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037202">
        <property type="entry name" value="ESCRT_assembly_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029012">
        <property type="entry name" value="Helix_hairpin_bin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009851">
        <property type="entry name" value="Mod_r"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13678:SF25">
        <property type="entry name" value="EG:115C2.5 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13678">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07200">
        <property type="entry name" value="Mod_r"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140111">
        <property type="entry name" value="Endosomal sorting complex assembly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51314">
        <property type="entry name" value="VPS37_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="5 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VPS37 C-terminal" evidence="9">
        <location>
            <begin position="239"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="115"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0797820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="326" mass="36944" checksum="4F0A2B47F58359F8" modified="2020-02-26" version="1">MLPGLYRSEIDIRKQQINTLKIFNDNVTEIQEGSEYQVLFKASNKEFCLHVQLTPEFPNDKPFLRISPVVVHPWVNADGDITSAPGLLNFTIHSDLGRVVQAIIREFARNPPPLTNDQSVTSPSGPSLGVESDTMGRSSPIYSYSYPSMAPVQQATHQSMAFPELNSLTLDELQFMNECVERQAEFVDNLPQTKEMNKAIDDLISNIEELADSNLSKKEHFEHLNKEIETKVDLVSKLAYENERLNLVYQSLSEKYSPKNIKEQLREAAEVSNSDSERVAEAFLNGDLDVDKFVTSYTKIRSLSQARKTKEEKLAQQLRNLEKAGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ALR2</accession>
    <name>A0A5N4ALR2_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_09196</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ALR2"/>
    <dbReference type="InParanoid" id="A0A5N4ALR2"/>
    <dbReference type="OrthoDB" id="412787at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000288">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050410">
        <property type="entry name" value="CCR4/nocturin_mRNA_transcr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121:SF37">
        <property type="entry name" value="2',5'-PHOSPHODIESTERASE 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121">
        <property type="entry name" value="CARBON CATABOLITE REPRESSOR PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="238"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0798203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="546" mass="63091" checksum="150F8A330C1E4A69" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-09-13" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ALY3</accession>
    <name>A0A5N4ALY3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_09309</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ALY3"/>
    <dbReference type="InParanoid" id="A0A5N4ALY3"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0798316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="50" mass="5610" checksum="209A59B9C137071F" modified="2020-02-26" version="1" fragment="single">FCDTLEDTFSLMVPACEDLICVGDFNINLLDESAQSLKFLDLLNTYGCMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ALY7</accession>
    <name>A0A5N4ALY7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Haemolymph juvenile hormone binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_09314</name>
        <name evidence="6" type="ORF">PPYR_09318</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ALY7"/>
    <dbReference type="FunCoup" id="A0A5N4ALY7">
        <property type="interactions" value="79"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4ALY7"/>
    <dbReference type="OrthoDB" id="8189372at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007623">
        <property type="term" value="P:circadian rhythm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.15.10.30:FF:000001">
        <property type="entry name" value="Takeout-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.30">
        <property type="entry name" value="Haemolymph juvenile hormone binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010562">
        <property type="entry name" value="Haemolymph_juvenile_hormone-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038606">
        <property type="entry name" value="To_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008">
        <property type="entry name" value="PROTEIN TAKEOUT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008:SF31">
        <property type="entry name" value="PROTEIN TAKEOUT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06585">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00700">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0090">Biological rhythms</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036147757" description="Haemolymph juvenile hormone binding protein" evidence="4">
        <location>
            <begin position="21"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00060902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0798321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0798325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="247" mass="27836" checksum="0DDBA1DDB6421EFE" modified="2020-02-26" version="1">MNNRVFLLCVIFGTVTSAIAQNSYYYLKRCRRTDPQINACLQKSANTFIAYMNHGIPELRLAEPEPLVIDEIGIALGNGPNGYRATFRDINAFGVSNMTITAVRSDLDSHQFQFTLFIPHISARAKYVSSGVLILVQASGGGDYWGEYDGVRAKVYVKAQPVTRQGRQHLTLQQIKMDFSVKEIQMGVTQVHNGNAVLEAALNLFINSNAQELLKEMKPDLKKKLTHLLWGFMENTFESIPYDEWII</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AMA6</accession>
    <name>A0A5N4AMA6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secernin-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_09462</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C69 family. Secernin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AMA6"/>
    <dbReference type="FunCoup" id="A0A5N4AMA6">
        <property type="interactions" value="15"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AMA6"/>
    <dbReference type="OrthoDB" id="5175656at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070004">
        <property type="term" value="F:cysteine-type exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.60.10">
        <property type="entry name" value="Penicillin V Acylase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005322">
        <property type="entry name" value="Peptidase_C69"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12994:SF17">
        <property type="entry name" value="LD30995P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12994">
        <property type="entry name" value="SECERNIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03577">
        <property type="entry name" value="Peptidase_C69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0798469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="391" mass="43563" checksum="3B70E6F1888FF500" modified="2020-02-26" version="1">MSNPDSSNAFVVLPPLSDHGVIFGKNSDRPQGEVQEIVYFPSDESAHTRKCTYVEVELSGPSKAVILSKPYWMWGAEMGANECGVVIGNVPVLTNNCEGDHDPQVQRLLGTDLVRLGLERSSSASEAVDVITQLLDQYGQGGSCFKDTNFCAHNSFLIADSKCAWVLETIGKHWAAEQVTKGYRNISNVLTITTNIDKKSEELLEYAKASGFWDGNGDFNFSEAFNKKGASSECYEAGKKLLENVTASNNFKETDMFKILRDDQSEICKPYDAKFPTQCSQVSVLSSDRPSVHWFTGTPHAVKSVFKPFVFTKNPTISKHTQCLSENEPHTLHSLHSEAIRKGSQVQNLLRKMEEECVEELNTIINSLGEDLSELDELFKDCVETEVKFYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AML3</accession>
    <name>A0A5N4AML3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">MADF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_09016</name>
        <name evidence="6" type="ORF">PPYR_09534</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AML3"/>
    <dbReference type="FunCoup" id="A0A5N4AML3">
        <property type="interactions" value="20"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AML3"/>
    <dbReference type="OrthoDB" id="6147983at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004210">
        <property type="entry name" value="BESS_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039353">
        <property type="entry name" value="TF_Adf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243">
        <property type="entry name" value="MADF DOMAIN TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243:SF60">
        <property type="entry name" value="SI:CH211-15D5.12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02944">
        <property type="entry name" value="BESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00595">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51031">
        <property type="entry name" value="BESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51029">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MADF" evidence="3">
        <location>
            <begin position="55"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="BESS" evidence="4">
        <location>
            <begin position="237"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="140"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="296"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="145"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="185"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="296"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="309"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="345"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0798023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0798541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="387" mass="43487" checksum="FC169DB739588B75" modified="2020-02-26" version="1">MFYIHNSHTKDTFGRYVVRFSAADSTCQTSRRFQLLFGQSAVMAHQKAECEFNLKLVEAVENFPCLYNYKLAEYARKDITEKAWTEVAKEVNDTVSKCKQKWQNVRTAFVRNLKSPPSGSGAKSKKPYYLAEHMQFVLPFVKPNTPDSDTQGNIPSTSEQHSEDESESIDESTAIADNTDEADATQASQGIGNDGTQTINRKKSANTVTNKRKPELSDADRAFVEFCDIRKKKTTDADPNQMFLLSLLPEVNAMNPLQMRRFKREVLNLIDNILDGKPAFSNQYFLNNTTPSSASPYISGNQNSFPTRNASNTPSPAPSSYYSEHSWPSRTSTPATATSSPRSSLYDSNNMEPSLITTNFRQLPQTDPHNGWKPSSSNTDYDLTYLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AMY4</accession>
    <name>A0A5N4AMY4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">6-pyruvoyl tetrahydrobiopterin synthase</fullName>
            <ecNumber evidence="4">4.2.3.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PPYR_09659</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; tetrahydrobiopterin biosynthesis; tetrahydrobiopterin from 7,8-dihydroneopterin triphosphate: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PTPS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.12" evidence="4"/>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AMY4"/>
    <dbReference type="FunCoup" id="A0A5N4AMY4">
        <property type="interactions" value="977"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AMY4"/>
    <dbReference type="UniPathway" id="UPA00849">
        <property type="reaction ID" value="UER00819"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003874">
        <property type="term" value="F:6-pyruvoyltetrahydropterin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006729">
        <property type="term" value="P:tetrahydrobiopterin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00470">
        <property type="entry name" value="PTPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.10:FF:000003">
        <property type="entry name" value="6-pyruvoyl tetrahydrobiopterin synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.10">
        <property type="entry name" value="6-pyruvoyl tetrahydropterin synthase/QueD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007115">
        <property type="entry name" value="6-PTP_synth/QueD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038418">
        <property type="entry name" value="6-PTP_synth/QueD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022469">
        <property type="entry name" value="PTPS_His_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12589:SF7">
        <property type="entry name" value="6-PYRUVOYL TETRAHYDROBIOPTERIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12589">
        <property type="entry name" value="PYRUVOYL TETRAHYDROBIOPTERIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01242">
        <property type="entry name" value="PTPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55620">
        <property type="entry name" value="Tetrahydrobiopterin biosynthesis enzymes-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00988">
        <property type="entry name" value="PTPS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0783">Tetrahydrobiopterin biosynthesis</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0798666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="139" mass="16127" checksum="C244982BF79D4C56" modified="2020-02-26" version="1">MAHKAYLTRREVLAACHRLHSPKLSNEENRAVFGKCNHPNGHGHNYVVEVTLHGEVNPKTGMLMNVTCLKEYMKSAIMDTMDHKNLDIDVPYFHDHPSTAEHVAIYIWQNMKKYMDDPSLLYEVKVFETENNIVLYRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ANL9</accession>
    <name>A0A5N4ANL9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sulfatase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_06807</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="PTM">
        <text evidence="6">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sulfatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0798927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ANL9"/>
    <dbReference type="InParanoid" id="A0A5N4ANL9"/>
    <dbReference type="OrthoDB" id="103349at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16029">
        <property type="entry name" value="4-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047115">
        <property type="entry name" value="ARSB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10342">
        <property type="entry name" value="ARYLSULFATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10342:SF264">
        <property type="entry name" value="MIP05773P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024390970" description="Sulfatase N-terminal domain-containing protein" evidence="7">
        <location>
            <begin position="21"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase N-terminal" evidence="8">
        <location>
            <begin position="24"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Ser)" evidence="6">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR600917-52"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0798927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="552" mass="61714" checksum="93E2A9C94B81EA24" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AP28</accession>
    <name>A0A5N4AP28_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cyclic nucleotide-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PPYR_06960</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AP28"/>
    <dbReference type="InParanoid" id="A0A5N4AP28"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015386">
        <property type="term" value="F:potassium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051453">
        <property type="term" value="P:regulation of intracellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098719">
        <property type="term" value="P:sodium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018422">
        <property type="entry name" value="Cation/H_exchanger_CPA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110">
        <property type="entry name" value="SODIUM/HYDROGEN EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110:SF86">
        <property type="entry name" value="SODIUM_HYDROGEN EXCHANGER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0915">Sodium</keyword>
    <keyword evidence="9" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="126"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="206"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="280"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="314"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="544"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="573"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="11">
        <location>
            <begin position="819"/>
            <end position="937"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAB0799080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1177" mass="134708" checksum="05CFD326077A3973" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AP95</accession>
    <name>A0A5N4AP95_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">UDP-glucuronosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_07045</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AP95"/>
    <dbReference type="InParanoid" id="A0A5N4AP95"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000021">
        <property type="entry name" value="UDP-glucuronosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF159">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024450241" description="UDP-glucuronosyltransferase" evidence="4">
        <location>
            <begin position="20"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0799165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="513" mass="58789" checksum="A22B89033565942D" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AS03</accession>
    <name>A0A5N4AS03_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_07990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0800110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AS03"/>
    <dbReference type="InParanoid" id="A0A5N4AS03"/>
    <dbReference type="OrthoDB" id="7333821at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0800110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="165" mass="18984" checksum="E377737A9FA412A4" modified="2020-02-26" version="1">MAQAFTTTYQKYYRQHPIERRKSLRPVDRFASELPEGGNWIVHKKVGEDDEGEVGLKAALAAIHKMNRGRLWTTYQMDYCGDMIAKEGEDEEQKPTGNAILIHGNKIYGPKTQQIPPPLPSARRIYGYIRPSRMYYPITTYEVTHGKVGYDVLLANHQATQKRQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AV50</accession>
    <name>A0A5N4AV50_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_05553</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000003">
        <property type="protein sequence ID" value="KAB0801199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AV50"/>
    <dbReference type="InParanoid" id="A0A5N4AV50"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0801199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="137" mass="15411" checksum="6BCD00B66938E30A" modified="2020-02-26" version="1">MFAARSLLAVEVFAPNEVAKRIFEEGVRWPISHSLWIFMAGFILFAALLVFFICATIYDQAIPNLPKPQLHRVSRSTDLQSLVSKGEKKKETSKINGNAVSYGSSRNRFKSDVTIEADVYADFDNDEYITFTAPPTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AVX5</accession>
    <name>A0A5N4AVX5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ZZ-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PPYR_05838</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000003">
        <property type="protein sequence ID" value="KAB0801484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AVX5"/>
    <dbReference type="FunCoup" id="A0A5N4AVX5">
        <property type="interactions" value="495"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AVX5"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010646">
        <property type="term" value="P:regulation of cell communication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0023051">
        <property type="term" value="P:regulation of signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099536">
        <property type="term" value="P:synaptic signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050774">
        <property type="entry name" value="KCMF1/Dystrophin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12268:SF27">
        <property type="entry name" value="DYSTROBREVIN, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12268">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE KCMF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00569">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50135">
        <property type="entry name" value="ZF_ZZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZZ-type" evidence="7">
        <location>
            <begin position="26"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="278"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="489"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="195"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="281"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="305"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="489"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="513"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0801484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="564" mass="62821" checksum="98CB8E8AAEC08AD6" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AVY6</accession>
    <name>A0A5N4AVY6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_05840</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntrophin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000003">
        <property type="protein sequence ID" value="KAB0801486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AVY6"/>
    <dbReference type="FunCoup" id="A0A5N4AVY6">
        <property type="interactions" value="56"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AVY6"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016010">
        <property type="term" value="C:dystrophin-associated glycoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06801">
        <property type="entry name" value="PDZ_syntrophin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000193">
        <property type="entry name" value="Syntrophin gamma 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015482">
        <property type="entry name" value="Syntrophin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055108">
        <property type="entry name" value="Syntrophin_4th"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10554:SF1">
        <property type="entry name" value="FI16515P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10554">
        <property type="entry name" value="SYNTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23012">
        <property type="entry name" value="Syntrophin_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="76"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="164"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="196"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0801486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="514" mass="58321" checksum="03B6D033A73302E8" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AW28</accession>
    <name>A0A5N4AW28_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_03761</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0801575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AW28"/>
    <dbReference type="InParanoid" id="A0A5N4AW28"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041515">
        <property type="entry name" value="PPAF-2-like_Clip"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051487">
        <property type="entry name" value="Ser/Thr_Proteases_Immune/Dev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24256">
        <property type="entry name" value="TRYPTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18322">
        <property type="entry name" value="CLIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024275289" description="Peptidase S1 domain-containing protein" evidence="3">
        <location>
            <begin position="21"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="4">
        <location>
            <begin position="145"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0801575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="405" mass="45346" checksum="3D5A30A62B89C532" modified="2020-02-26" version="1">MHRVELVGLLVASLLIGSHSHRFSKGQSSIAYTIVKTFDEISNQNDKLKTIIKSFFGDQSTSTKAPEPAEGECLCTPFYLCNNGEVNRDGSKLFEPRYVIKICKSVNPCKTVGDICCQSLTRSPPLREKDDRISDNYSCGYGSEIPGDYYISDPTTAKFGEYPWTALVLNLKNQYQCVGSLIHPEVVLTTAHCINDSENYIARVGQWNTTGNIEPLAHQNMSVKSIVKHPKFVFDNLIHNAALLFLENPFKLDRNVNTACLADSSTVPYTQLRKSKCAATGWGSDVPKGIYRRAMKKIEFSLISNPLCQNEFRKTRLGKWFQLHQTFLCAFGKNGRDLCYGDGGGPLVCEISRQPLRYLQVGITSWGLGCANNLPSVFTKVTSIKHWIDQEMSARNLDTSYYTPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AWP9</accession>
    <name>A0A5N4AWP9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PPYR_03846</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">1611_PpyrPB1</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0801660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AWP9"/>
    <dbReference type="InParanoid" id="A0A5N4AWP9"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11056">
        <property type="entry name" value="CYP6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000042">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050476">
        <property type="entry name" value="Insect_CytP450_Detox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292:SF93">
        <property type="entry name" value="CYTOCHROME P450 310A1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0492">Microsome</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="457"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAB0801660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="513" mass="58859" checksum="8E948C47F721B5C7" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-06-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AWS1</accession>
    <name>A0A5N4AWS1_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_03991</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0801805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AWS1"/>
    <dbReference type="InParanoid" id="A0A5N4AWS1"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0801805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="105" mass="12136" checksum="B493CB4DDE42E409" modified="2020-02-26" version="1">MCTCADCPYLLIYYIEIVTDASSNDKHITYCNNHKYVTCTTLFAVLSKKQLFVKELLIKRSFHRCGWTDSRLFIDITAKTVVQVKMLNDSFTPAEISRIVYILSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AYW0</accession>
    <name>A0A5N4AYW0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PPYR_04715</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AYW0"/>
    <dbReference type="FunCoup" id="A0A5N4AYW0">
        <property type="interactions" value="8"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AYW0"/>
    <dbReference type="OrthoDB" id="546450at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000006">
        <property type="entry name" value="Serine proteinase stubble"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252">
        <property type="entry name" value="ACROSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252:SF7">
        <property type="entry name" value="HYALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024371050" description="Peptidase S1 domain-containing protein" evidence="6">
        <location>
            <begin position="26"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="7">
        <location>
            <begin position="72"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0802529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="312" mass="34964" checksum="4AD351CE2AFE54C7" modified="2020-02-26" version="1">MALLQQKNFLYQCVLFFLLICLIEGEPRQRGLKDTFLAKLGFGNSNYPPPRHDTPASPCTCSCGVRNDATRIVGGQTTAQNEFPWMCRLSYFNRFYCGGMLINDRYVLTAAHCVKGFMWFMIKVTFGEHDRCDDKKRPESRYVIRAITGAFSFLHFDNDIALLRLNDRVPITDAISPVCLPKDTDDLYVGRKGIAAGWGTLQEEGKPSCLLQEVEVPIISNEECRATNYSEKMISDNMMCAGYPATGGKDSCQGDSGGPFIIERPDKRYSLIGVVSWGNGCARPGYPGVYTRVTRYLDWILHNAADGCFCED</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AYW9</accession>
    <name>A0A5N4AYW9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Sugar phosphate transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_04725</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AYW9"/>
    <dbReference type="FunCoup" id="A0A5N4AYW9">
        <property type="interactions" value="907"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AYW9"/>
    <dbReference type="OrthoDB" id="78344at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005459">
        <property type="term" value="F:UDP-galactose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005460">
        <property type="term" value="F:UDP-glucose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013657">
        <property type="entry name" value="SCL35B1-4/HUT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778:SF10">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08449">
        <property type="entry name" value="UAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="297"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0802539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="321" mass="35303" checksum="8E063F87A175153D" modified="2020-02-26" version="1">MQGSTKFMVCAAGIFVCYFYFGILQEKITRGKYSNDEVSENGAIRKVDERFTCALALVFVQCLVNYFFAKGMLYVKPHGEDTTPTIYCASSALTYLLAMVCSYMALQWVAFPTQVVGKAGKPIPVMVLGVLIGRKSYPLKKYVFVLMIVIGVILFMYKDKAGSKKVDGFGLGELLILLSLTMDGLTGAVQERIKAEAKPTAQQMMSGMNKFACIFVVVPILLSGELIKFIEFVTRHPTVLSNILLLALAGALGQLFIFLTVTEFGPLPCSVITTTRKFFTVLGSVLIFGNVLTVRQWIGAIIVFTGLFLDVFFSKGAPKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B0D7</accession>
    <name>A0A5N4B0D7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PPYR_05199</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0803013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B0D7"/>
    <dbReference type="FunCoup" id="A0A5N4B0D7">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4B0D7"/>
    <dbReference type="OrthoDB" id="546450at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000006">
        <property type="entry name" value="Serine proteinase stubble"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252">
        <property type="entry name" value="ACROSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252:SF7">
        <property type="entry name" value="HYALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024274331" description="Peptidase S1 domain-containing protein" evidence="6">
        <location>
            <begin position="19"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="7">
        <location>
            <begin position="58"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0803013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="311" mass="34638" checksum="48A9EEDA31897DFF" modified="2020-02-26" version="1">MDKVWFIVFVLFVVSVVSVPLKDTNRARKGKNFYDDNILHPSSDCNCVCGMSDRQIRVVGGNVTKENEFPWLAGMAKNGEFHCGGTLITRKHVLTAAHCVDGINYRTISIAFGDHDRKDKERFSKIQVRKIKKVVPHKLFDRSTYNNDIAILELDHPLHFDSKIQPACLPHSAVTDYSGKWAIVAGWGKTGEKQESSTILRKAIVPIWPKKDCYNSGYGEERLSENMFCAGFEEGKIDACQGDSGGPLHVKNPNGIMDVVGIVSWGRGCGRATLPGIYTKIINYLDWILEGLNGECLCPPPPTSNQNLRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B2C2</accession>
    <name>A0A5N4B2C2_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zinc finger PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_00717</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B2C2"/>
    <dbReference type="InParanoid" id="A0A5N4B2C2"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd15517">
        <property type="entry name" value="PHD_TCF19_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0803747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="263" mass="29580" checksum="2ED6D84BBE68EC69" modified="2020-02-26" version="1">MKNTPNRKLNRLQFGKLLGESWGKSASVHNAVSAFKSTGVMPFNPQIIPDYAFLIIEDTMNTPDNQNRPTQDIPVIHQQQPITPQPKQHKTRHHPQISPQPGPSGNRTESHETPPKITPGKALDLISPVPTIAPLTQKVKRNLSRVITSPEYIGYRKEVASKKQRKSVVVKSKAISKSRVVTPRDESSSSESENLVLDDTSSGEEELEEYENECAGCHEDYRQTQRKDDWIQCVTCKRWLHEGCTSFENVCLPCGKSLSKKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B372</accession>
    <name>A0A5N4B372_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PPYR_01029</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B372"/>
    <dbReference type="InParanoid" id="A0A5N4B372"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF1">
        <property type="entry name" value="FI18259P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="248"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0804059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="364" mass="40731" checksum="848AB6274B8F658A" modified="2020-02-26" version="1">MSDSVCDAIHQRDRSGYNDTDEIAVQKVVASAHRILWSTLSLVLYALAGLYAYYKVKEEAPIEKKTRTKYELMKDIVNIKKTLSTFHFLVKPNRLIQRKQIFVILFLAILILGPFVGEGTLIYLYTRLKFNWDEIHYSIYFGYTSVAHLMGNFSALLIFSQWLKFDDAILGAISSGSKICGGIVFILAEKSFLFYIASRSIITKLVDEKDLGKVNSLLGVAESITILLYVPVYSALYTATLNIFSASFYVGIFLTIPAILLYSSLTVTIFSLSIFSKCLKLDDSLIGIISGSSKALSSLVYAFAPNTTIFYLGTIMESFSGTSYIAVKSLISKLVEPEELGTLPICRLFTVYKFGSPYHTLSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B3X2</accession>
    <name>A0A5N4B3X2_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Golgi SNAP receptor complex member 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PPYR_01262</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 10">Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Golgi apparatus</location>
            <location evidence="8">cis-Golgi network membrane</location>
            <topology evidence="8">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the GOSR2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B3X2"/>
    <dbReference type="FunCoup" id="A0A5N4B3X2">
        <property type="interactions" value="2290"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4B3X2"/>
    <dbReference type="OrthoDB" id="158360at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15863">
        <property type="entry name" value="SNARE_GS27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027027">
        <property type="entry name" value="GOSR2/Membrin/Bos1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230:SF1">
        <property type="entry name" value="GOLGI SNAP RECEPTOR COMPLEX MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230">
        <property type="entry name" value="VESICLE TRANSPORT V-SNARE PROTEIN VTI1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12352">
        <property type="entry name" value="V-SNARE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028865">
        <property type="entry name" value="Membrin-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR028865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAB0804292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="211" mass="24426" checksum="4CA76383ECA0ABE1" modified="2020-02-26" version="1">MDTLYHQTNILVQQTQECFQLLETRPTNYQEIESNIQEKISLINRNCEKLDTFLFKLPLTQRQNAKMNCDQLKYDSRHLQAALMSLQQKRIRKQAAATEREQLLGQRFTANPELTAINIDHAFQQQNSLNNAHRGVDEMLQTGTGTLESLRLQRNTLKGAHRRIVDMANTLGLSNHTMRLIEKRVGEDKFILFGGMIITLLIIIIVIIYFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B497</accession>
    <name>A0A5N4B497_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_01343</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B497"/>
    <dbReference type="InParanoid" id="A0A5N4B497"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33939:SF1">
        <property type="entry name" value="DUF4371 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33939">
        <property type="entry name" value="PROTEIN CBG22215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0804373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="126" mass="14917" checksum="3D9D12D61C402C69" modified="2020-02-26" version="1">MHMTYQIRFATKLTLALLEPSHRFYLIITHIGSVKRFVDRGSLVFQSKRTGDYHEDMNADVLEEYFDQMLSLLPENSVIVMDNASYHSRHLENLPRSSWKKSDIAIFKCFYHRRSSNIKKNIYTVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B5G0</accession>
    <name>A0A5N4B5G0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ABC transmembrane type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PPYR_01821</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B5G0"/>
    <dbReference type="InParanoid" id="A0A5N4B5G0"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000026">
        <property type="entry name" value="Multidrug resistance-associated protein lethal(2)03659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000014">
        <property type="entry name" value="Multidrug resistance-associated protein member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000482">
        <property type="entry name" value="Multidrug resistance-associated protein member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF448">
        <property type="entry name" value="FI20146P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="238"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="320"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="727"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="775"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="854"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="881"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="966"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="95"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="412"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="731"/>
            <end position="995"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0804851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="995" mass="111676" checksum="5F3A6C1ACF02950D" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B665</accession>
    <name>A0A5N4B665_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7869 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_02077</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0805107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B665"/>
    <dbReference type="InParanoid" id="A0A5N4B665"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057191">
        <property type="entry name" value="DUF7869"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10773:SF19">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10773">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25273">
        <property type="entry name" value="DUF7869"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7869" evidence="2">
        <location>
            <begin position="459"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0805107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="725" mass="84227" checksum="FF1C16D6E8AB198D" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B745</accession>
    <name>A0A5N4B745_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_02333</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0805363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B745"/>
    <dbReference type="InParanoid" id="A0A5N4B745"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF269">
        <property type="entry name" value="NUCLEASE HARBI1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="8">
        <location>
            <begin position="76"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0805363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="272" mass="31242" checksum="244BB25A6EBB9D6B" modified="2020-02-26" version="1">MMDVVEYLSTGMTFSSLGYEFQIARSTIGTIIRETCEAIWSTLKEQEMPEPTEEVWLGIADQFYLKTNFPNCVGTIDGKHIRCMNPRRGGSNFFNYKKFFSIVLMAVVDANLRFVAIDVGAYGKEGDSTVFRDSPLGKKLYSGSLNLPPPRCLPNTQPEEIPQPFVMVGDEAFKLHTNLLKPYPSRNMNATKRVFNYRLSRCRRNVECAFGVLANKWRIFHTPILVQPSFVDKIVQACCILHNFVRKRDVRDYFAQYFMGAGAVHFQRSYMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B9H6</accession>
    <name>A0A5N4B9H6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PPYR_02660</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">1611_PpyrPB1</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0805690.1"/>
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    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
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    <keyword evidence="6" id="KW-0677">Repeat</keyword>
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    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
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        <location>
            <begin position="426"/>
            <end position="450"/>
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        <location>
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    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="507"/>
            <end position="528"/>
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    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="549"/>
            <end position="571"/>
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    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="591"/>
            <end position="615"/>
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    <feature type="transmembrane region" description="Helical" evidence="13">
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            <begin position="642"/>
            <end position="664"/>
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    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="676"/>
            <end position="696"/>
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    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="14">
        <location>
            <begin position="442"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="772"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="807" mass="92005" checksum="BF8231C004CE5494" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1JSD4</accession>
    <name>A0A1Y1JSD4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">carnitine O-palmitoyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">PPYR_11050</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="21 22" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">1611_PpyrPB1</strain>
            <tissue evidence="21">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">1611_PpyrPB1</strain>
            <tissue evidence="21">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>(R)-carnitine + hexadecanoyl-CoA = O-hexadecanoyl-(R)-carnitine + CoA</text>
            <dbReference type="Rhea" id="RHEA:12661"/>
            <dbReference type="ChEBI" id="CHEBI:16347"/>
            <dbReference type="ChEBI" id="CHEBI:17490"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="EC" id="2.3.1.21"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:12662"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the carnitine/choline acetyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.21" evidence="5"/>
    <dbReference type="EMBL" id="GEZM01101959">
        <property type="protein sequence ID" value="JAV52162.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1JSD4"/>
    <dbReference type="FunCoup" id="A0A1Y1JSD4">
        <property type="interactions" value="746"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1JSD4"/>
    <dbReference type="UniPathway" id="UPA00659"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004095">
        <property type="term" value="F:carnitine O-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009437">
        <property type="term" value="P:carnitine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.70:FF:000001">
        <property type="entry name" value="Carnitine O-palmitoyltransferase 1, liver isoform"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000042">
        <property type="entry name" value="Carnitine Palmitoyl Transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.70">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000542">
        <property type="entry name" value="Carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039551">
        <property type="entry name" value="Cho/carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042231">
        <property type="entry name" value="Cho/carn_acyl_trans_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032476">
        <property type="entry name" value="CPT_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589">
        <property type="entry name" value="CARNITINE O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589:SF31">
        <property type="entry name" value="CARNITINE O-PALMITOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00755">
        <property type="entry name" value="Carn_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16484">
        <property type="entry name" value="CPT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00439">
        <property type="entry name" value="ACYLTRANSF_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="97"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Carnitine O-palmitoyltransferase N-terminal" evidence="19">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="Choline/carnitine acyltransferase" evidence="18">
        <location>
            <begin position="174"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="16">
        <location>
            <position position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR600542-1"/>
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                <person name="Bessho-Uehara M."/>
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                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
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                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
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                <person name="Lower S.E."/>
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                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01091306">
        <property type="protein sequence ID" value="JAV56934.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1K6D9"/>
    <dbReference type="InParanoid" id="A0A1Y1K6D9"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000013">
        <property type="entry name" value="lactase-phlorizin hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353:SF36">
        <property type="entry name" value="LP05116P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036029752" description="Myrosinase 1-like" evidence="7">
        <location>
            <begin position="22"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="JAV56934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0804172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="495" mass="56805" checksum="48039F530B53D7DA" modified="2017-08-30" version="1">MWFRTQCSAVLLLIFLHVCECKTGSNKIILPSYLLIGVASSAYQIEGAWNADGKGESIWDRMTHNMTFKIRDGSNGDVACDSYNQIKEDVDMVRKLRVQFYRFSIAWTRILPNGFPNKINKAGVRYYNRLINRLLKKGITPIATIYHWDLPQALQDLGGWANPLVQYWFEGYAKVLFENFGDRIKMWVTVNEPQQICSFTYSTGVYAPGIVSDGIGTYICYHNLLKAHARVYHLYNSTFRQSQKGQIGINTEVTWFEPATNSTADKAAAERRWEFECGIIAHPIFSADGDYPNLVKQIVAKRSKEEGFPESRLPRLTAEEIGFIKGTSDFFGLNHYATLKVKPSKPLKGTSEFNDVGVKIVKEYECKDTPWSYYFRSVPWAFTKLLADIKSRYQNPDVYIFETGIPDEGGTLDDQHRIKYIKENLAAVVSAVHEEGVKVRAFTLWSLMDSFEWRGGYTYRFGLYSVNFTTPKRTRIPKASALYLRSIMKNREFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1KDT6</accession>
    <name>A0A1Y1KDT6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CLIP domain-containing serine protease</fullName>
            <ecNumber evidence="8">3.4.21.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PPYR_04477</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="9">The clip domain consists of 35-55 residues which are 'knitted' together usually by 3 conserved disulfide bonds forming a clip-like compact structure.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 9">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="8"/>
    <dbReference type="EMBL" id="GEZM01087707">
        <property type="protein sequence ID" value="JAV58521.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1KDT6"/>
    <dbReference type="InParanoid" id="A0A1Y1KDT6"/>
    <dbReference type="OrthoDB" id="8114044at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000028">
        <property type="entry name" value="Serine protease easter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000002">
        <property type="entry name" value="Transmembrane protease serine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022700">
        <property type="entry name" value="CLIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038565">
        <property type="entry name" value="CLIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252">
        <property type="entry name" value="ACROSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252:SF7">
        <property type="entry name" value="HYALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12032">
        <property type="entry name" value="CLIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00680">
        <property type="entry name" value="CLIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51888">
        <property type="entry name" value="CLIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 8" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 8" id="KW-0720">Serine protease</keyword>
    <keyword evidence="2 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034080614" description="CLIP domain-containing serine protease" evidence="9">
        <location>
            <begin position="34"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="Clip" evidence="11">
        <location>
            <begin position="39"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="10">
        <location>
            <begin position="143"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="JAV58521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAB0802291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="399" mass="43750" checksum="CB9E8E2862EE0880" modified="2017-08-30" version="1">MLKFYKYATRSSMTALWFYVCVFLPLVFEKCNTAERGSKCITPNQEVASCTPITTCHIIRDAITTRNQSAIEFAQKSQCGHDTEPLVCCGTSAYSAEPYYFSYFTKAPATPPPKKLIPGLSSVSTNTLPDRTICGIERESQRLIGATVAAIDEFPWMVLIRYNNDQGEDVGFKCGATLINNRYVLTAAHCILTSPEPISPVSVRLGEWKISTDTDCVYNIAISTCSDSVVDVKIDQQTPHPYFSSSNGNNDIGLLRLEKDVLYTDFIRPICLPAVDVPPPPIGTLMTVSGWGATEEGNQADIKSKIEIPLISNSDCEKTVSKYTRITPNQVCAGGVEGKDACKGDSGGPLMRTYVDDTSQWYQEGVVSRGRGCGKKGFPGVYTRVARYVNWILNVIAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1KHE9</accession>
    <name>A0A1Y1KHE9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ras-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_05442</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
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        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
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        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
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        </source>
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</entry>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
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                <person name="Lewis S.M."/>
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            <dbReference type="DOI" id="10.1038/srep38556"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
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                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Photinus pyralis genome working group"/>
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                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">1611_PpyrPB1</strain>
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        </source>
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        <text evidence="17">This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane.</text>
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    <comment type="similarity">
        <text evidence="2">Belongs to the X(+)/potassium ATPases subunit beta family.</text>
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        <property type="entry name" value="NA_K-ATPASE BETA SUBUNIT ISOFORM 4-RELATED"/>
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        <property type="entry name" value="SODIUM/POTASSIUM-DEPENDENT ATPASE BETA SUBUNIT"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="8" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="11" id="KW-0915">Sodium</keyword>
    <keyword evidence="16" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="6" id="KW-0740">Sodium/potassium transport</keyword>
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        <location>
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            <end position="68"/>
        </location>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
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    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00025540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="JAV63332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAB0797930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="22">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="319" mass="36976" checksum="C16C397C328F6C4D" modified="2017-08-30" version="1">MAEKKTEQFYTRPPKLGKWESFKIFLWNSETHQFLGRTGGSWGKIILFYLLFYAALIGFFAAMLTIFYQTLDDKKPKWQLDRSLIGSNPGLGFRPMPPESNVESTLIWYKASDQTSTQYWIEQLEDFLKPYARERSHDEPVCHQGIPPPPGSDKVCDVKVTDWNPCTRSTGYNFNSTEGGPCIFLKLNKIFGWEPQYYNYSTLPDLMPSELRQHIKKKEDELSTKPNGLKVVWVSCEGENPGDIENIGPIHYYPNLGFEGQYFPFLNVHDYISPLVVVYFEKPTRGVLINIECKAWARNIVHDRAEKRGSVHFELMVDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1KRK0</accession>
    <name>A0A1Y1KRK0_PHOPY</name>
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        <recommendedName>
            <fullName evidence="2">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="4" type="ORF">PPYR_03210</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
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            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01077641">
        <property type="protein sequence ID" value="JAV63218.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="JAV63222.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1KRK0"/>
    <dbReference type="InParanoid" id="A0A1Y1KRK0"/>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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        <property type="entry name" value="SERINE PROTEASE GD-LIKE PROTEIN"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF16030">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011907282" description="Peptidase S1 domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="2">
        <location>
            <begin position="183"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="JAV63218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0791410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="413" mass="45604" checksum="4A26848E2D207612" modified="2017-08-30" version="1">MVSIKFLFACVISCVSALNRTSPCPRLFAYERNTSASNRWYGVVTVSSETALEGVWLRLAFDGELQQLGNWFGEVRANDNNREFVIKNRSFKLEANVPHQVRFYAQYDEGRPVPGLVSVQINAKTVCPDEGVVVRTTAKSSTTAKPNIPLRISDDEDYFIGDFGILNRQQATSTSPLDGCGTVTGGGHETEYPWHASIYYTNGVDLVHICAGNLLSKAYVLTAARCLYKDPHTAIFPDELVVYFGKHNLRSFSSVGLQVRGVSDFVLHPLFNSSTSVHNLALLKLAAAVEVSNYVRAICLWRDEGVDEDGVTVGWGVDQMGKFRPELTRGQLQIASKQLCPSVSADTFCTIFKAGTVTCNADSGGGFFSARGGVWYLRGVLSVVNKEVRCDPLKYLTVTDVSKYLEWIKQFII</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1KU01</accession>
    <name>A0A1Y1KU01_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Virilizer N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_08608</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
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        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
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                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the vir family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01076747">
        <property type="protein sequence ID" value="JAV63680.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A1Y1KU01">
        <property type="interactions" value="2363"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1KU01"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036396">
        <property type="term" value="C:RNA N6-methyladenosine methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="InterPro" id="IPR031801">
        <property type="entry name" value="VIR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026736">
        <property type="entry name" value="Virilizer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23185">
        <property type="entry name" value="PROTEIN VIRILIZER HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23185:SF0">
        <property type="entry name" value="PROTEIN VIRILIZER HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15912">
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Virilizer N-terminal" evidence="7">
        <location>
            <begin position="5"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="210"/>
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        </location>
    </feature>
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        <location>
            <begin position="310"/>
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        </location>
    </feature>
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        <location>
            <begin position="1661"/>
            <end position="1680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="236"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="310"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="357"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1665"/>
            <end position="1677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF15912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="JAV63680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0797615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1784" mass="203579" checksum="318A13757FBE7F19" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1KVP6</accession>
    <name>A0A1Y1KVP6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Enolase</fullName>
            <ecNumber evidence="3">4.2.1.11</ecNumber>
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        <alternativeName>
            <fullName evidence="8">2-phospho-D-glycerate hydro-lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">2-phosphoglycerate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PPYR_11734</name>
    </gene>
    <organism evidence="15">
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        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
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        <lineage>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">1611_PpyrPB1</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
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            <name>Mg(2+)</name>
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        <text evidence="12">Mg(2+) is required for catalysis and for stabilizing the dimer.</text>
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    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the enolase family.</text>
    </comment>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enolase N-terminal" evidence="14">
        <location>
            <begin position="3"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Enolase C-terminal TIM barrel" evidence="13">
        <location>
            <begin position="142"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="344"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="158"/>
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        <ligand>
            <name>substrate</name>
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        <ligand>
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        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
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        </ligand>
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        <location>
            <position position="294"/>
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        <ligand>
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        </ligand>
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        <ligand>
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        <ligand>
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        <ligand>
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        <location>
            <position position="395"/>
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        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00005031"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012058"/>
        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="435" mass="47114" checksum="8031E93DBC6CCF26" modified="2017-08-30" version="1">MPIKSVFARQIFDSRGNPTVEVDLVTDLGLFRAAVPSGASTGVHEALELRDNDKQKYHGKGVLKAVGHVNDSIGPALLKESFEVTQQREIDDFMLKLDGTENKSKFGANAILGVSLAVAKAGAAKRGIPLYKHLADLAGNSNIILPVPAFNVINGGSHAGNKLAMQEFMILPTGAQTFSEAMKMGSEVYHHLKSVIKSKFGLDATAVGDEGGFAPNIQSNKEALNLISDAIAKAGYTGRIEIGMDVAASEFFKDGKYDLDFKNPQSDKSLWLAADKLEAMYQDFIKNFPIVSIEDPFDQDDWSAWTAMTGNTSIQIVGDDLTVTNPKRIATAVEKKACNCLLLKVNQIGTVSESIDAHLLARKNGWGTMVSHRSGETEDTFIADLVVGLSTGQIKTGAPCRSERLAKYNQILRIEEELGSAAKYAGKHFRNPHKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Photinus pyralis</name>
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            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
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    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
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                <person name="Lewis S.M."/>
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            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
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                <person name="Bessho-Uehara M."/>
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                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
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                <person name="Nelson D.R."/>
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                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
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            <dbReference type="PubMed" id="30324905"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
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    <reference evidence="11" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bZIP family. C/EBP subfamily.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="term" value="C:nucleus"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="bZIP"/>
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        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR23334:SF69">
        <property type="entry name" value="CCAAT_ENHANCER-BINDING PROTEIN GAMMA"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF07716">
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        <property type="match status" value="1"/>
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    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="9">
        <location>
            <begin position="20"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="52"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="JAV67103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0803319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="114" mass="12593" checksum="AFBC23C7AF055B76" modified="2017-08-30" version="1">MAPKRGKAKVAPETESGDDSDEYRKKRDRNNLAVKRSRIKSKQKTQETVNRVTQLKSENTVLEEKVKNLTKELGFLKELFLAHAGSAGDASKFEGIDLQKLLSDPSDGASTSNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1L1R1</accession>
    <name>A0A1Y1L1R1_PHOPY</name>
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        <recommendedName>
            <fullName evidence="8">DOD-type homing endonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PPYR_00999</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sel-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01066958">
        <property type="protein sequence ID" value="JAV67618.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01066956">
        <property type="protein sequence ID" value="JAV67622.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1L1R1"/>
    <dbReference type="FunCoup" id="A0A1Y1L1R1">
        <property type="interactions" value="628"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1L1R1"/>
    <dbReference type="OrthoDB" id="27934at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050767">
        <property type="entry name" value="Sel1_AlgK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11102">
        <property type="entry name" value="SEL-1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11102:SF147">
        <property type="entry name" value="SEL1L ADAPTOR SUBUNIT OF ERAD E3 UBIQUITIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011907322" description="DOD-type homing endonuclease domain-containing protein" evidence="4">
        <location>
            <begin position="23"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="694"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="21"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="61"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="JAV67622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0804029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="724" mass="80832" checksum="E8608E3533F51166" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1L377</accession>
    <name>A0A1Y1L377_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_09360</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01066146">
        <property type="protein sequence ID" value="JAV68138.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01066145">
        <property type="protein sequence ID" value="JAV68139.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1L377"/>
    <dbReference type="InParanoid" id="A0A1Y1L377"/>
    <dbReference type="OrthoDB" id="7694537at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="JAV68139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0798367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="496" mass="56441" checksum="2BD2B1E261AB09F1" modified="2017-08-30" version="1">MVFSSVPFGYSLALIFFVGTHIKVSMENEFNSQQNVWSQFSNNTSWHYFDQASVAKHTFLELLSILERFGLPQDINDAKERLIDLVLADEIDVSIVMTYTQRFNEESAFDRMIAALLTLKDTIPSSCPLGFGIGNLILYAVFNKHRFDSHSSDICDKLSELPQYVATCDQSCDVHKRLEILQSDYCGRAQMVEVAKVENVAVNTASSTQVVDVLRSAVDATQLVSLLPVPESQQEISNLETLKSYMSSSEMKQYLQQISTSEHGSSTEVLRIVLKHIVETSVEISIKRIAYTYLTYMESTGESRKLFDYSILTKFLPQPINEEEDSYYATVLSFLQGTDIHYYLRNLGEIDSTNLALLYKQVLRTLAEDLELELNIRAAFKYYYDYEELFDDVELEAHRVLHKKFSLRKVLNGIFTELPLEYRDGLKLLLRFVSKYPATMNTFEIPTEVVTYGQLGRSVLDFLQASEQVPAVVKTAIITLIPHISYDGAGALLIQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1L3E8</accession>
    <name>A0A1Y1L3E8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="12">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PPYR_00299</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">1611_PpyrPB1</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">1611_PpyrPB1</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. Possesses 5' single-stranded RNA overhang nuclease activity.</text>
    </comment>
    <comment type="function">
        <text evidence="12">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="12">The helicase domain is involved in the stimulation of RELA transcriptional activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DEAD box helicase family. DDX1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="12"/>
    <dbReference type="EMBL" id="GEZM01067947">
        <property type="protein sequence ID" value="JAV67311.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
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        <property type="protein sequence ID" value="KAB0803329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="ConA-like_dom_sf"/>
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        <property type="entry name" value="Helicase_ATP-bd"/>
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        <property type="entry name" value="Helicase_C-like"/>
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        <property type="entry name" value="P-loop_NTPase"/>
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        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
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        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
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        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DEXDc"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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    </dbReference>
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        <property type="entry name" value="B302_SPRY"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="16">
        <location>
            <begin position="2"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="13">
        <location>
            <begin position="67"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="251"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="480"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="11">
        <location>
            <begin position="2"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
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        </source>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00058016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="JAV67311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAB0803329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="729" mass="81702" checksum="2F5A6DAEC0DEC9D8" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1L4W7</accession>
    <name>A0A1Y1L4W7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein zwilch</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PPYR_06321</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the RZZ complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Chromosome</location>
            <location evidence="1 9">Centromere</location>
            <location evidence="1 9">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the ZWILCH family.</text>
    </comment>
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    </dbReference>
    <dbReference type="GO" id="GO:0051301">
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034501">
        <property type="term" value="P:protein localization to kinetochore"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN ZWILCH HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="3 9" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 9" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="5 9" id="KW-0498">Mitosis</keyword>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU369076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="JAV68739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0800581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="578" mass="66335" checksum="E4F8A19A767440A7" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1L6R5</accession>
    <name>A0A1Y1L6R5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PPYR_09781</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bZIP family. PAR subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01068007">
        <property type="protein sequence ID" value="JAV67266.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0795720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1L6R5"/>
    <dbReference type="InParanoid" id="A0A1Y1L6R5"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14695">
        <property type="entry name" value="bZIP_HLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000007">
        <property type="entry name" value="hepatic leukemia factor isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040223">
        <property type="entry name" value="PAR_bZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11988:SF27">
        <property type="entry name" value="GH27708P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11988">
        <property type="entry name" value="THYROTROPH EMBRYONIC FACTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="9">
        <location>
            <begin position="175"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="107"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="207"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="132"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="JAV67266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0795720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="241" mass="27006" checksum="71D9E513DEB16F9E" modified="2017-08-30" version="1">MSYKDRGSPILLESGLKSFLGHPGHNYPLLNGNSKPAHPHGHGHSAIKDLAGGILSNDDKSKDDGELWNNVDAQTAFLGPNLWDKTYESDLKYVDLDEFLSENGVSMDGLGSHTPNGSISNSHGVAKRERSPSPSDCMSPDTMNPPSPADSNEDLKPQPLIKKSRKQFVPDDLKDDKYWARRRKNNLAAKRSRDARRMKENQIALRAGYLEKENLTLRSELERLKKENVMLKNKLAKYEDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1L7J4</accession>
    <name>A0A1Y1L7J4_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_09209</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclin family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01066382">
        <property type="protein sequence ID" value="JAV67915.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1L7J4"/>
    <dbReference type="FunCoup" id="A0A1Y1L7J4">
        <property type="interactions" value="93"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1L7J4"/>
    <dbReference type="OrthoDB" id="5590282at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044772">
        <property type="term" value="P:mitotic cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20508">
        <property type="entry name" value="CYCLIN_CCNB3_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20510">
        <property type="entry name" value="CYCLIN_CCNB3_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000001">
        <property type="entry name" value="G2/mitotic-specific cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046965">
        <property type="entry name" value="Cyclin_A/B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001771">
        <property type="entry name" value="Cyclin_A_B_D_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 4" id="KW-0195">Cyclin</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="6">
        <location>
            <begin position="269"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="7">
        <location>
            <begin position="362"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="6">
        <location>
            <begin position="366"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="100"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="119"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="134"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="JAV67915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0798216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="484" mass="55023" checksum="37EDAEF0609F4F14" modified="2017-08-30" version="1">MAPAKSVKPVTEIFITKNRTTRLASKPLSVVNGNQPRVKRKADASPVKDTIATKRSALGDVTNQKKTLVHINKAKQTITNVPKKVTVKSTVLPSVKTVVKPKQNENAAPPNAPAQKVQTRASLRNSDVNSTALKPKETSKDPRVKTRLSNEFEKSEVSLYSSALEEINDSTRLSSGPPVTRSQTSQVSKSANVTLVALQLETQLNLGNHEVPDGVTDFDKENWNDVFQASHYTMDIFNYLKSREPLYTVRDYMDSQSCLTRWMRSLLVDWMVEVQESFELNHETLYLGVKLVDYYLSKVIISKEILQLVGAASMLIASKYDERIPPLIDDFLYICDGAYTHKELVRMEINILKVSDINLGFPLSYRFLRRYARCLKISMPVLTLARFILEYSLMDYGTIFTPDSKLASASLYLALKMKQLQPWNKALEFYSGYKLEQIMSTVHLLNTGLHRKPREQLMTIRNKYSHKIFFEVAKTPLIKNEDLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LBR7</accession>
    <name>A0A1Y1LBR7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">ATP-binding cassette sub-family B member 10, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">ABC-mitochondrial erythroid protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">ATP-binding cassette transporter 10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">PPYR_07005</name>
    </gene>
    <organism evidence="24">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="25 26" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">1611_PpyrPB1</strain>
            <tissue evidence="25">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="25" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="25">1611_PpyrPB1</strain>
            <tissue evidence="25">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">ATP-dependent transporter located in the mitochondrial inner membrane that catalyzes the export of biliverdin from the mitochondrial matrix, and plays a crucial role in hemoglobin synthesis and antioxidative stress. Participates in the early step of the heme biosynthetic process during insertion of iron into protoporphyrin IX (PPIX). Involved in the stabilization of the iron transporter mitoferrin-1/SLC25A37. In addition may be involved in mitochondrial unfolded protein response (UPRmt) signaling pathway, although ABCB10 probably does not participate in peptide export from mitochondria.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>biliverdin IXalpha(in) + ATP + H2O = biliverdin IXalpha(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:82359"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57991"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:82360"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Mitochondrial peptide exporter (TC 3.A.1.212) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01060299">
        <property type="protein sequence ID" value="JAV71112.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1LBR7"/>
    <dbReference type="FunCoup" id="A0A1Y1LBR7">
        <property type="interactions" value="792"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1LBR7"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18573">
        <property type="entry name" value="ABC_6TM_ABCB10_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03249">
        <property type="entry name" value="ABC_MTABC3_MDL1_MDL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000048">
        <property type="entry name" value="ATP-binding cassette sub-family B member 10, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000403">
        <property type="entry name" value="ATP-binding cassette sub-family B member 8, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF1">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B MEMBER 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002773">
        <property type="entry name" value="ABC_prm/ATPase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="11" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="108"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="253"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="335"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="376"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="23">
        <location>
            <begin position="110"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="22">
        <location>
            <begin position="430"/>
            <end position="669"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00052250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00055589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00072683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00075187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00083334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="JAV71112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="KAB0799125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="677" mass="75217" checksum="EE39D4223E8A869A" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LCA2</accession>
    <name>A0A1Y1LCA2_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Putative nuclease HARBI1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Harbinger transposase-derived nuclease</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PPYR_05172</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">1611_PpyrPB1</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">1611_PpyrPB1</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Transposase-derived protein that may have nuclease activity. Does not have transposase activity.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HARBI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01060077">
        <property type="protein sequence ID" value="JAV71296.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01060076">
        <property type="protein sequence ID" value="JAV71299.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1LCA2"/>
    <dbReference type="InParanoid" id="A0A1Y1LCA2"/>
    <dbReference type="OrthoDB" id="2415966at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
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        <source>
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    <sequence length="633" mass="71896" checksum="A1D5597880D22B4C" modified="2017-08-30" version="1"> </sequence>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
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                <person name="Bessho-Uehara M."/>
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                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
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                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
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                <person name="Sander Lower S.E."/>
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                <person name="Bessho-Uehara M."/>
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                <person name="Debat H.J."/>
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                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
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                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
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                <person name="Weng J.K."/>
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                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
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        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
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        <subcellularLocation>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:outer dynein arm assembly"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Ribonuclease Inhibitor"/>
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    </dbReference>
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        <property type="entry name" value="Leu-rich_rpt"/>
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        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454:SF73">
        <property type="entry name" value="DYNEIN AXONEMAL LIGHT CHAIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454">
        <property type="entry name" value="NISCHARIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0243">Dynein</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7" id="KW-0505">Motor protein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00049659"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00049760"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="JAV82129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAB0804168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
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</entry>
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    <organism evidence="3">
        <name type="scientific">Photinus pyralis</name>
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        <lineage>
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            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
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            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01035663">
        <property type="protein sequence ID" value="JAV83136.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="InParanoid" id="A0A1Y1MGY5"/>
    <dbReference type="OrthoDB" id="7671074at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
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    </dbReference>
    <proteinExistence type="predicted"/>
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        </location>
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        </location>
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        </location>
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        <location>
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        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAB0800995.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="390" mass="45939" checksum="683CF4DB009CBD30" modified="2017-08-30" version="1">MATMIITAFVLILFVQQCVAQSEPNTKQSGKYSEEYCDPCRVDKRIRRDVEKKGSENETQNQNPAVAAKLTSNASAVADNEFVRLRRGTDRDAVQQDVENVKHAIDEYSSNEKQVRTARMLLQDNNDVPDGFREARGATREQWVKQPYPVTIDDTNFEDNMAASSDRAPRAHFVTQRRLEPSPAIYRMQEREGRSRELYRDSDRDLPPSASRVPPSHFEYYPERPSKRFESYPIRSFNPYRDDPYYRYEESRYDPRYGSPESERPRSDFPTRQRRIIYYATLPEVVRTPPNVNLRNRYVYRDPYDDRYVTSPSQPAAEESSYRFRKPSTPYTKSRHEQEIERTKASYPLKVSTDVNVRETKKNPERRIYSEPESRYAYKAQSKESFDQRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1ML79</accession>
    <name>A0A1Y1ML79_PHOPY</name>
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        <recommendedName>
            <fullName evidence="9">Sestrin homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_14255</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
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            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
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        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a hydroperoxide + L-cysteinyl-[protein] = S-hydroxy-L-cysteinyl-[protein] + an alcohol</text>
            <dbReference type="Rhea" id="RHEA:67124"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:17193"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:61973"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:67125"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sestrin family.</text>
    </comment>
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        <property type="protein sequence ID" value="JAV84646.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070728">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0071233">
        <property type="term" value="P:cellular response to L-leucine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990253">
        <property type="term" value="P:cellular response to leucine starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:positive regulation of macroautophagy"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:regulation of response to reactive oxygen species"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Sestrin 1"/>
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        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="AhpD-like"/>
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        <property type="entry name" value="Sestrin"/>
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    <dbReference type="PANTHER" id="PTHR12474">
        <property type="entry name" value="P53 REGULATED PA26 NUCLEAR PROTEIN SESTRIN"/>
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    </dbReference>
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        <property type="entry name" value="SESTRIN HOMOLOG"/>
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    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008350"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00049242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="JAV84646.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAB0792296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="463" mass="53268" checksum="B2AC3DE65FC5509E" modified="2017-08-30" version="1">MGHIQQNVSSAGYFDGNVQLETATHTLFVDAFLQNNRLDHVTQVMGYHPAYLDHFLRTQHFILRGDGPLPYDYRHYIAIMASGRHQCNYLIALQKQEFLLQGGAHTWLKGLDYIPQKLRNLYDINKILAHQPWLLNKSHIEKLTKGKDSWSLAEVVHAIVILTHFHSLCSFVFSCGVNQEVDQIGAHTYPASDGGTNATAICVDPSNINISKSQPKDIPISNRKDWKYSSNLSPPSPTEPEVGITTLMQRMKTLSEHNEECTPVELTKRFENVESQSAELGAVGAEPQEAPADICVFVEDPSFIYHDFAKRHDDDIVTFRVQDYSWDDHGYSLVNRLYNDVGNLLDDKFKTAYNLTYYTMGGRTDVDTSRFRRAIWNYIQCLLGIRHDDYNYGEINQLLERTLKTFIKSACCYPERVTKKDYDRVLREFKHSEKVHVNLMVLEARMQAELLYALRTVNRYMTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1MLU1</accession>
    <name>A0A1Y1MLU1_PHOPY</name>
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        <recommendedName>
            <fullName evidence="1">COMM domain-containing protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_03509</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
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        <text evidence="2">Belongs to the COMM domain-containing protein 3 family.</text>
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        <property type="molecule type" value="Transcribed_RNA"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="126"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00016548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00093469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="JAV86643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0791709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="201" mass="22988" checksum="A9459C33DF2DF3F4" modified="2017-08-30" version="1">MVFRLEIKMNITEELKNRVKFIGTSPIKDDLFKQLLEHNFSTLTGKPENLSVLYNSKPDLIKEAHAILMTISAEFGRHDLTKEEVRSFLIDCNFSTGRAAVFSELYDRNKRDLQVALGKIGSHPPHIVDAEWKIDYIVKASNLDHSEGPIFRIALVTSKFDEDSGSKGIERVYFTCNGQELQDLVYKLKDAVRHCQRLTSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1MTG6</accession>
    <name>A0A1Y1MTG6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PPYR_09937</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GEZM01021495">
        <property type="protein sequence ID" value="JAV88972.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0795876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1MTG6"/>
    <dbReference type="FunCoup" id="A0A1Y1MTG6">
        <property type="interactions" value="90"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1MTG6"/>
    <dbReference type="OrthoDB" id="10018191at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990837">
        <property type="term" value="F:sequence-specific double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000404">
        <property type="entry name" value="POZ-, AT hook-, and zinc finger-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000303">
        <property type="entry name" value="Zinc finger protein 41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000395">
        <property type="entry name" value="zinc finger protein 513"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF49">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="338"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="375"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="403"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="431"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="18"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="101"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="JAV88972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAB0795876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="468" mass="52630" checksum="F013C0A62B98C16D" modified="2017-08-30" version="1">MTMAEIAIESSIPHEKTYNNNNNIDLPLTKGQNRPPAKQRKRKRLSQVLDKLTGHVTNLPLANIINNNNQILNVPEENGCALITTKHMSGEVFRFDNADKERYQQQSEDEDVFSPASSSNKSPHSSSDSPRISFSPLRLKDDDASSSPPLSRPACPCYQCVIGVSHHPPPPFYPYDRFFPASPISPVTPSSPAPPTYNFERYLHSKYLPDIFRKRSHSDSDIPLWFEYAKTERTRHPPAWLQPLSLVKGSVESDPSTPQDSPLDLSMHKRNQRGSMDCLPGPLQILPTGFLPPRGAVSVPIVQGDVASPTTKRSVASRYNLEVSPVVEEMPPGSDVAYVCPVCGQMFSLHDRLAKHMASRHKSRQSPGETTAKAYLCEVCKRSFARSDMLTRHMRLHTGVKPYTCRVCGQVFSRSDHLSTHQRTHTGEKPYKCPQCPYAACRRDMITRHMRTHTRYEPDPLTAVKSEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1N188</accession>
    <name>A0A1Y1N188_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">1-Cys peroxiredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PPYR_08503</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a hydroperoxide + [protein]-dithiol = [protein]-disulfide + an alcohol + H2O</text>
            <dbReference type="Rhea" id="RHEA:10008"/>
            <dbReference type="Rhea" id="RHEA-COMP:10593"/>
            <dbReference type="Rhea" id="RHEA-COMP:10594"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peroxiredoxin family. Prx6 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01015464">
        <property type="protein sequence ID" value="JAV91629.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01015463">
        <property type="protein sequence ID" value="JAV91630.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1N188"/>
    <dbReference type="FunCoup" id="A0A1Y1N188">
        <property type="interactions" value="447"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1N188"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03016">
        <property type="entry name" value="PRX_1cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1020.10:FF:000001">
        <property type="entry name" value="1-Cys peroxiredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000011">
        <property type="entry name" value="Peroxiredoxin PRX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1020.10">
        <property type="entry name" value="Antioxidant, Horf6, Chain A, domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019479">
        <property type="entry name" value="Peroxiredoxin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045020">
        <property type="entry name" value="PRX_1cys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43503">
        <property type="entry name" value="MCG48959-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43503:SF4">
        <property type="entry name" value="PEROXIREDOXIN-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10417">
        <property type="entry name" value="1-cysPrx_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="3 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1 9" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="4 9" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="11">
        <location>
            <begin position="2"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity" evidence="10">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00026176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="JAV91629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAB0797510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="220" mass="24815" checksum="8CF8780E00716863" modified="2017-08-30" version="1">MVNLGEPFPNFQANTTVGPIQFYDWLGNSWGVLFSHPSDFTPVCTTELARVIQLHGEFERRGVKVIALSCDSVESHHAWANDIKMYAKCDSQDALPYPIIADERRELAVQLNMIDPDEVDAQGMPLTARAVFVVDPNKKMRLSILYPATTGRNFDEILRAIDSLQLTDKHRVATPVDWKPGDFVMVQPTVPDQHIPTLFPYTTVIPLPSGKRYLRQTPQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1N5K5</accession>
    <name>A0A1Y1N5K5_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_04213</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01015005">
        <property type="protein sequence ID" value="JAV91935.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1N5K5"/>
    <dbReference type="InParanoid" id="A0A1Y1N5K5"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036312590" evidence="2">
        <location>
            <begin position="20"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="JAV91935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0802027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="190" mass="21564" checksum="F2F786E97B4CE408" modified="2017-08-30" version="1">MYYICVLLNTFFGILIADSASNGNIDISNQKVTKESVLLPFPTDSSKYVILNVTAKPGKIAAVEVDDLLHGGLYANISHHTEMQKPALVINVIEEKNSEKLSDIKWDTELIEDGTNTEDKRVRYVVHTSSKTHNLVSHQLPLALTISAVVIVIITGSVAYFTWRKFEYRCRRRELLINRMDPDDMRHFSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1N5T2</accession>
    <name>A0A1Y1N5T2_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Arrestin C-terminal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_05525</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arrestin family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01014741">
        <property type="protein sequence ID" value="JAV92015.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000003">
        <property type="protein sequence ID" value="KAB0801171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1N5T2"/>
    <dbReference type="FunCoup" id="A0A1Y1N5T2">
        <property type="interactions" value="39"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1N5T2"/>
    <dbReference type="OrthoDB" id="2333384at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF17">
        <property type="entry name" value="FI21816P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="E set domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0716">Sensory transduction</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="3">
        <location>
            <begin position="169"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="JAV92015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0801171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="333" mass="37556" checksum="5B87F88E24B1D57D" modified="2017-08-30" version="1">MPRKLLKFLILFDNTSLLYFPGQFLSGRVLIELQDDTPALGLHFHVVGEGVVRIRTPRQERLYDRENYIDFRMRLLGEPGQNGSVLSPGIHSFPFKLGLPLGLPSTFLGKHGWVQYYCKAALKEPNGLTHKNQQVFIVMNPIDLNLEPSILSQPFRCEIEHKLGVSCVGSGPVVCRVTLDRGGYVPGESIGISASVQNRSNVTVKSTRAALTETIQYMARGKVVQSERRELACLTRGKIRPGESDEWTNEQLYVPPLPPTNLRGCHLIKIQYDVYFIIEPKSLDKEVKLQLPIMLATYPLRTEENGASYKSGTHYPSTLPIFRPWLEDKPVLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1N9K8</accession>
    <name>A0A1Y1N9K8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Protein krueppel</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PPYR_09521</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01009556">
        <property type="protein sequence ID" value="JAV94531.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01009554">
        <property type="protein sequence ID" value="JAV94533.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1N9K8"/>
    <dbReference type="InParanoid" id="A0A1Y1N9K8"/>
    <dbReference type="OrthoDB" id="9439903at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031519">
        <property type="term" value="C:PcG protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000065">
        <property type="entry name" value="B-cell CLL/lymphoma 6, member B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001397">
        <property type="entry name" value="Datilografo, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:003288">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000045">
        <property type="entry name" value="ZFP69 zinc finger protein B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000557">
        <property type="entry name" value="zinc finger and SCAN domain-containing protein 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000303">
        <property type="entry name" value="Zinc finger protein 41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001004">
        <property type="entry name" value="Zinc finger protein 426"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012934">
        <property type="entry name" value="Znf_AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003:SF19">
        <property type="entry name" value="YY2 TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07776">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00868">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51915">
        <property type="entry name" value="ZAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZAD" evidence="12">
        <location>
            <begin position="13"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="171"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="199"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="269"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="297"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="325"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="353"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="381"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="409"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="437"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="465"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="493"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="JAV94533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAB0798528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="540" mass="61106" checksum="BAC501D591AB1EBE" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1NA15</accession>
    <name>A0A1Y1NA15_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Pre-mRNA-processing-splicing factor 8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Splicing factor Prp8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PPYR_14045</name>
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    <organism evidence="12">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Plays a role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes, both of the predominant U2-type spliceosome and the minor U12-type spliceosome. Functions as a scaffold that mediates the ordered assembly of spliceosomal proteins and snRNAs. Required for the assembly of the U4/U6-U5 tri-snRNP complex, a building block of the spliceosome. Functions as a scaffold that positions spliceosomal U2, U5 and U6 snRNAs at splice sites on pre-mRNA substrates, so that splicing can occur. Interacts with both the 5' and the 3' splice site.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GEZM01009723">
        <property type="protein sequence ID" value="JAV94358.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A1Y1NA15">
        <property type="interactions" value="2788"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1NA15"/>
    <dbReference type="OrthoDB" id="1931567at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097157">
        <property type="term" value="F:pre-mRNA intronic binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030619">
        <property type="term" value="F:U1 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030620">
        <property type="term" value="F:U2 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030623">
        <property type="term" value="F:U5 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13838">
        <property type="entry name" value="RNase_H_like_Prp8_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.40:FF:000001">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.230:FF:000003">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.43.40:FF:000001">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000002">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1570.40:FF:000001">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1570.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.40">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8, U5-snRNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012591">
        <property type="entry name" value="PRO8NT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012592">
        <property type="entry name" value="PROCN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012984">
        <property type="entry name" value="PROCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027652">
        <property type="entry name" value="PRP8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021983">
        <property type="entry name" value="PRP8_domainIV"/>
    </dbReference>
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        <property type="entry name" value="Prp8_domainIV_fingers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043172">
        <property type="entry name" value="Prp8_domainIV_palm"/>
    </dbReference>
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        <property type="entry name" value="Prp8_U5-snRNA-bd"/>
    </dbReference>
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        <property type="entry name" value="Prp8_U5-snRNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019580">
        <property type="entry name" value="Prp8_U6-snRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019582">
        <property type="entry name" value="RRM_spliceosomal_PrP8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11140">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR PRP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11140:SF0">
        <property type="entry name" value="PRE-MRNA-PROCESSING-SPLICING FACTOR 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08082">
        <property type="entry name" value="PRO8NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08083">
        <property type="entry name" value="PROCN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08084">
        <property type="entry name" value="PROCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12134">
        <property type="entry name" value="PRP8_domainIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10598">
        <property type="entry name" value="RRM_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10597">
        <property type="entry name" value="U5_2-snRNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10596">
        <property type="entry name" value="U6-snRNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
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    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="MPN" evidence="11">
        <location>
            <begin position="2133"/>
            <end position="2264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00055739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00071757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00079260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="JAV94358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAB0792084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="2365" mass="276275" checksum="EA22D0B254DDE857" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1NA90</accession>
    <name>A0A1Y1NA90_PHOPY</name>
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        <recommendedName>
            <fullName evidence="16">Inositol 1,4,5-trisphosphate receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">PPYR_05817</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="21 22" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">1611_PpyrPB1</strain>
            <tissue evidence="21">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">1611_PpyrPB1</strain>
            <tissue evidence="21">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Endoplasmic reticulum membrane</location>
            <topology evidence="1 16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="16">The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the InsP3 receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01013553">
        <property type="protein sequence ID" value="JAV92487.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KAB0801463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="interactions" value="296"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1NA90"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070679">
        <property type="term" value="F:inositol 1,4,5 trisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005220">
        <property type="term" value="F:inositol 1,4,5-trisphosphate-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051209">
        <property type="term" value="P:release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd23277">
        <property type="entry name" value="beta-trefoil_MIR_ITPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000002">
        <property type="entry name" value="Inositol 1,4,5-trisphosphate receptor type 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000005">
        <property type="entry name" value="Inositol 1,4,5-trisphosphate receptor type 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.30:FF:000001">
        <property type="entry name" value="Inositol 1,4,5-trisphosphate receptor, type 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.30">
        <property type="entry name" value="IP3 receptor type 1 binding core, RIH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014821">
        <property type="entry name" value="Ins145_P3_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000493">
        <property type="entry name" value="InsP3_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
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    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
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        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013662">
        <property type="entry name" value="RIH_assoc-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000699">
        <property type="entry name" value="RIH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015925">
        <property type="entry name" value="Ryanodine_IP3_receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035910">
        <property type="entry name" value="RyR/IP3R_RIH_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45816">
        <property type="entry name" value="MIR DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR45816:SF4">
        <property type="entry name" value="RYR_IP3R HOMOLOGY ASSOCIATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08709">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08454">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01365">
        <property type="entry name" value="RYDR_ITPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00779">
        <property type="entry name" value="INSP3RECEPTR"/>
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        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="IP3 receptor type 1 binding core, domain 2"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
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        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 16" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="4 16" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 16" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="15 16" id="KW-0407">Ion channel</keyword>
    <keyword evidence="11 16" id="KW-0406">Ion transport</keyword>
    <keyword evidence="14 16" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="12 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="13 16" id="KW-0675">Receptor</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 16" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="2245"/>
            <end position="2278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="2284"/>
            <end position="2306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="2332"/>
            <end position="2351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="2371"/>
            <end position="2399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="2420"/>
            <end position="2442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="2541"/>
            <end position="2564"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="19">
        <location>
            <begin position="113"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="19">
        <location>
            <begin position="234"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="19">
        <location>
            <begin position="297"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1131"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1839"/>
            <end position="1869"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="2672"/>
            <end position="2706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="1131"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="1845"/>
            <end position="1866"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU368044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="JAV92487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAB0801463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="2719" mass="308328" checksum="9DAD17F7E2B7A382" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1NBE3</accession>
    <name>A0A1Y1NBE3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein takeout</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_02785</name>
        <name evidence="6" type="ORF">PPYR_14554</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TO family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01007373">
        <property type="protein sequence ID" value="JAV95221.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0790985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1NBE3"/>
    <dbReference type="FunCoup" id="A0A1Y1NBE3">
        <property type="interactions" value="31"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1NBE3"/>
    <dbReference type="OrthoDB" id="8190514at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007623">
        <property type="term" value="P:circadian rhythm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.15.10.30:FF:000001">
        <property type="entry name" value="Takeout-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.30">
        <property type="entry name" value="Haemolymph juvenile hormone binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010562">
        <property type="entry name" value="Haemolymph_juvenile_hormone-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038606">
        <property type="entry name" value="To_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008:SF18">
        <property type="entry name" value="BCDNA.GH05536-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008">
        <property type="entry name" value="PROTEIN TAKEOUT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06585">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00700">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0090">Biological rhythms</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00060902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="JAV95221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0790985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0792595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="267" mass="30103" checksum="9463E0B2727CB66B" modified="2017-08-30" version="1">MMVITHASKVCVIKSTAVHFSRKTMKTAVLLLTCVTVAVRGLDLPFQKCERSTPNLNECMKSAIQDALPILKRGLPEFQFESIEPIRIESLTIGEGKGAVHVVQNYKNVEIHNVQTAKVERVDAVITDDEFKVVADLTIKDVHMNAQYSLNGNILMLPINGEGDCAVDLEDLKATFTMIGEMFEKDGKKYMELKTFNVSLVPGLVEFNFENLFSGERQLGDEMNKLLNENWRKIYLDVRAAYEEALGAVFKSIANLIFKKIPYDEMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1NGR0</accession>
    <name>A0A1Y1NGR0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">Myelin regulatory factor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="24">Myelin gene regulatory factor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="32" type="ORF">PPYR_03229</name>
    </gene>
    <organism evidence="31">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="31" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="32 33" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="32">1611_PpyrPB1</strain>
            <tissue evidence="32">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="32" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="32">1611_PpyrPB1</strain>
            <tissue evidence="32">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="22">Constitutes a precursor of the transcription factor. Mediates the autocatalytic cleavage that releases the Myelin regulatory factor, N-terminal component that specifically activates transcription of central nervous system (CNS) myelin genes.</text>
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    <comment type="function">
        <text evidence="21">Membrane-bound part that has no transcription factor activity and remains attached to the endoplasmic reticulum membrane following cleavage.</text>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MRF family.</text>
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        <property type="protein sequence ID" value="JAV96949.1"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016540">
        <property type="term" value="P:protein autoprocessing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Myelin regulatory factor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NDT80 DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051577">
        <property type="entry name" value="MRF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025719">
        <property type="entry name" value="MYRF_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026932">
        <property type="entry name" value="MYRF_ICA"/>
    </dbReference>
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        <property type="entry name" value="NDT80_DNA-bd_dom"/>
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        <property type="entry name" value="NDT80_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030392">
        <property type="entry name" value="S74_ICA"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13029:SF18">
        <property type="entry name" value="MYELIN REGULATORY FACTOR HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13888">
        <property type="entry name" value="MRF_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13887">
        <property type="entry name" value="MYRF_ICA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NDT80_PhoG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13884">
        <property type="entry name" value="Peptidase_S74"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ICA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NDT80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0010">Activator</keyword>
    <keyword evidence="10" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="14 26" id="KW-0175">Coiled coil</keyword>
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    <keyword evidence="15 25" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
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    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="33" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="18" id="KW-0804">Transcription</keyword>
    <keyword evidence="13" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7 28" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 28" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="28">
        <location>
            <begin position="732"/>
            <end position="757"/>
        </location>
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    <feature type="domain" description="NDT80" evidence="29">
        <location>
            <begin position="263"/>
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        </location>
    </feature>
    <feature type="domain" description="Peptidase S74" evidence="30">
        <location>
            <begin position="569"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="NDT80" evidence="25">
        <location>
            <begin position="263"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="27">
        <location>
            <begin position="69"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="26">
        <location>
            <begin position="664"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="27">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
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    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
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    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00057438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00060149"/>
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    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00067854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00075238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS51517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="PROSITE" id="PS51688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="EMBL" id="JAV96949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="EMBL" id="KAB0791429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="33">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1069" mass="119864" checksum="288519A78DD33273" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1NHY6</accession>
    <name>A0A1Y1NHY6_PHOPY</name>
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        <recommendedName>
            <fullName evidence="2">26S proteasome non-ATPase regulatory subunit 9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">26S proteasome regulatory subunit p27</fullName>
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    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_01769</name>
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    <organism evidence="6">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
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                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
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            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit p27 family.</text>
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    </dbReference>
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        <property type="protein sequence ID" value="KAB0804799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="InParanoid" id="A0A1Y1NHY6"/>
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    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070682">
        <property type="term" value="P:proteasome regulatory particle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000107">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1710">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nas2_N"/>
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        <property type="entry name" value="PDZ"/>
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        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035269">
        <property type="entry name" value="PSMD9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12651">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12651:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18265">
        <property type="entry name" value="Nas2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="106"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="JAV97512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0804799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="203" mass="22696" checksum="43C81698815CA688" modified="2017-08-30" version="1">MNETTEIREHVLQLMKQKDDIENTIKELTEILTKNGVGMNDPLVDQDGFPISSIDIYQVRHARHRIICLQNDHKSLMKQIENGLHGYYSSSTHLPANNSLREEQASHVGNSVTNKTPFAKVTIVSPGSPAEIAGIQVNDLIVEFGSVNFSNFNNIVDIANVVQHSEGQQLYVKLQRGDRYITTYLIPKKWTGKGLLGCNIVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-06-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N3ZXL2</accession>
    <name>A0A5N3ZXL2_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_15760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01002143">
        <property type="protein sequence ID" value="KAB0789952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N3ZXL2"/>
    <dbReference type="InParanoid" id="A0A5N3ZXL2"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0789952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="237" mass="28648" checksum="613C29BA29809389" modified="2020-02-26" version="1">MYHRLRRKCKYNPREYKSRRAYDRVMNQKGTIYRRKLIATGKLSDTLKMNAAERLFALLPGYLQWAKIRVLEDWRERNRKAKDRLYQLQKRRREFVERALRSRDTDRLIICFLKRPLVLQKIFAEGEDFRPAIKFLLGQRITNYVVRLVEVLRESSTFQTRAEEFLQKGRRMPSFVPTFEAVHRDSPFVDARHPRLPLMYRKQLNRLMSSKKVVEAMVCAVRCKWNYPKIFPPSMTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N3ZYI5</accession>
    <name>A0A5N3ZYI5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7869 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_15557</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01001891">
        <property type="protein sequence ID" value="KAB0790124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N3ZYI5"/>
    <dbReference type="InParanoid" id="A0A5N3ZYI5"/>
    <dbReference type="OrthoDB" id="6741802at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057191">
        <property type="entry name" value="DUF7869"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10773:SF19">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10773">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25273">
        <property type="entry name" value="DUF7869"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7869" evidence="2">
        <location>
            <begin position="437"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0790124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="707" mass="83552" checksum="7C80095D40A8A9C5" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N3ZYV8</accession>
    <name>A0A5N3ZYV8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_15429</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01001635">
        <property type="protein sequence ID" value="KAB0790240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N3ZYV8"/>
    <dbReference type="InParanoid" id="A0A5N3ZYV8"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23080:SF133">
        <property type="entry name" value="SI:CH211-262I1.5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23080">
        <property type="entry name" value="THAP DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="3">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0790240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="146" mass="16396" checksum="3E3E2311EB629C20" modified="2020-02-26" version="1" fragment="single">CTEMRIERSSNPVIQQATYSTYYGTNTFKILVAGTENGEIAFVSDVYGGSITDRKISEVSGLLDLLKGGDYVLADRGFDISDLLEERHVHLNIPPFKRANQLTEEEVFKTRAIANRRIIIENLIGAAKKKQNFNKSNPTTFVEHSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N3ZZ26</accession>
    <name>A0A5N3ZZ26_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_15350</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01001517">
        <property type="protein sequence ID" value="KAB0790312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N3ZZ26"/>
    <dbReference type="InParanoid" id="A0A5N3ZZ26"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF269">
        <property type="entry name" value="NUCLEASE HARBI1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="8">
        <location>
            <begin position="3"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0790312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="131" mass="15219" checksum="C449767FCC51D810" modified="2020-02-26" version="1" fragment="single">MPHVIIADEAYPLMKHLLKPYRKQELNADKEYFNKRLSCARRTVECAFGILRSKWQILDKPILTHPGHADNIIKAICILHNVIIDKEGIEHNLKETQFVFQNENRQAPAGRLNNEAKVVRDNFKAYLCNNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N3ZZ85</accession>
    <name>A0A5N3ZZ85_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_15245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01001386">
        <property type="protein sequence ID" value="KAB0790381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N3ZZ85"/>
    <dbReference type="InParanoid" id="A0A5N3ZZ85"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0790381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="257" mass="28591" checksum="E9861776675E00AB" modified="2020-02-26" version="1">MSAGGSKSRGNRILQLALRSNAVQSNLRENNLDTLNESSGELNNKDLPPAKSTESVQLPSLNLTTKELPDESSRDFYDNNNENLSPSESWLEDSGSEYVPSETESHTNKENLIDVDNEVHDVVETEVDGRKGSKRKSKGQADPKLWKRIKNAKLRVHGKSYTGFEKDINGKYRQTAVKSERKLGPKCSGHQAKSGKGGPRQGFKCSDVSNSQMEHVFTSFWALSSWEAKKSFVMGHVLPVTPKRRNSQRNKIKGGCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A3R2</accession>
    <name>A0A5N4A3R2_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PPYR_13917</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0791956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A3R2"/>
    <dbReference type="InParanoid" id="A0A5N4A3R2"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14341">
        <property type="entry name" value="UBA_MELK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000271">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000003">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.80">
        <property type="entry name" value="Kinase associated domain 1, KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028375">
        <property type="entry name" value="KA1/Ssp2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001772">
        <property type="entry name" value="KA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF30">
        <property type="entry name" value="MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02149">
        <property type="entry name" value="KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103243">
        <property type="entry name" value="KA1-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50032">
        <property type="entry name" value="KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="11"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="KA1" evidence="13">
        <location>
            <begin position="547"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="347"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAB0791956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="605" mass="67622" checksum="16420BFA8F807A10" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A3Z0</accession>
    <name>A0A5N4A3Z0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Oxysterol-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_13973</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the OSBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A3Z0"/>
    <dbReference type="InParanoid" id="A0A5N4A3Z0"/>
    <dbReference type="OrthoDB" id="1854502at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097038">
        <property type="term" value="C:perinuclear endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015485">
        <property type="term" value="F:cholesterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120009">
        <property type="term" value="P:intermembrane lipid transfer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.120:FF:000001">
        <property type="entry name" value="Oxysterol-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018494">
        <property type="entry name" value="Oxysterol-bd_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF203">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01013">
        <property type="entry name" value="OSBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="2" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="305"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="227"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="317"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0792012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="728" mass="82148" checksum="83697BCB9A6BBB0A" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A443</accession>
    <name>A0A5N4A443_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Medium-chain specific acyl-CoA dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="5">1.3.8.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PPYR_14038</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">1611_PpyrPB1</strain>
            <tissue evidence="19">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a medium-chain 2,3-saturated fatty acyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = a medium-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:14477"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:83723"/>
            <dbReference type="ChEBI" id="CHEBI:83726"/>
            <dbReference type="EC" id="1.3.8.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; mitochondrial fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.8.7" evidence="5"/>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A443"/>
    <dbReference type="FunCoup" id="A0A5N4A443">
        <property type="interactions" value="623"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A443"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070991">
        <property type="term" value="F:medium-chain fatty acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051793">
        <property type="term" value="P:medium-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000010">
        <property type="entry name" value="Medium-chain specific acyl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000011">
        <property type="entry name" value="Medium-chain specific acyl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000007">
        <property type="entry name" value="Medium-chain specific acyl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050741">
        <property type="entry name" value="Acyl-CoA_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083:SF2">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016578">
        <property type="entry name" value="HsaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15" id="KW-0274">FAD</keyword>
    <keyword evidence="9" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="7 15" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="18">
        <location>
            <begin position="40"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="17">
        <location>
            <begin position="155"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="16">
        <location>
            <begin position="264"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAB0792077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="420" mass="45725" checksum="139210D38B8D7F7E" modified="2020-02-26" version="1">MSTLKKILLRNAPTLLRGATSTAVQPNPDVSGGYNFALDDTQREVQALARKFAREDVLPVASHYDKTGEYPWPLVKKAWSLGLSNSHIPTQYGGMGQSTFNGCLITEEIAYACTGVGAGIEASSLGQKPVLLAGTEEQKRKYLGRLTEEPLVVSYAVTESGAGSDVNGLKTKAVKKGDEWILNGQKMWITGAGVANWYFVLARTDPDPKTPANRAFTGFIVEREWDGVTPGRKEINMGQRASDTRGITFEDVRVPKENVLLGEGEGFKIAMGAFDKTRPPIAAGATGLAHRALDEASKYALERKTFGVPIASHQAIAFMLADMAIGVETSRLLWQKAAWVADLGQRNSYEAAIAKCYACDTANKNASDAVQIFGGNGFNTEYPVEKLMRDAKIYQIYEGTSQIQHIVISRHIIDQAKRSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A5M2</accession>
    <name>A0A5N4A5M2_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_14595</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A5M2"/>
    <dbReference type="InParanoid" id="A0A5N4A5M2"/>
    <dbReference type="OrthoDB" id="6478865at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21261">
        <property type="entry name" value="BEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024332584" description="Ig-like domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="36"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="239"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0792636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="297" mass="32690" checksum="E8FD224A47F616F4" modified="2020-02-26" version="1">MCKWTLCLALLIGLFLEALGTVIISELTGGDTAQIGSNNTLICSFVLKDETGVEVKWFYNDNKQIVSWIPTRTRPQAIGAFKSILDFADVAENETTRSVVRFRDLNFNLTGRYTCKVSGDVDEKSETLNMIVYQPASSVEFVEDDGNVTCSAYDVYPEPTISITISYTTGRDDPVPTLEILGTEEKTDDNFYNVTKTLVLDKSLLNQTVHFTCNVFIPGTVFNETLTVTIEVERYESTTDYPDTTTDPTTFAPVTTSTTIKTSTLKPTTGQGDSGVEAGTSPVHLLFYLAVLLGLQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A7H4</accession>
    <name>A0A5N4A7H4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_12890</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A7H4"/>
    <dbReference type="InParanoid" id="A0A5N4A7H4"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492:SF102">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="2">
        <location>
            <begin position="300"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0793270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="456" mass="52394" checksum="E21FCB016E03B18A" modified="2020-02-26" version="1">MSHTVYRLNVHLEGEGPQYFRRGAEDKVKAKIFEGNAKLSQLEMFMKQCLEESRQQISEIRNVTFAQLPETHWFNQKTNRWQKRKRERKIVGRLYPVLPNHTEKFALYQLLLYKKGPLGWDDLKTPPNSTTPCKTFVECAKLMGLLDDIEIWRRTLFEASNVGNPRTMRNLFAQILLLGYVADPLALWNEFLPHMYDTRNLRQNDEIERSRRINIALCLLNRLLGHHFTNNAFFHIPMPENYNAVCDDENEFFFGQNRALDGENESDPTLAEFPLQRRNDDAIETEDIGNYATLASYLRLNEEQKIVVDIVVRAMQSSPSDATTPRLVFMNGAGGTGKTFVYKTIIDMFIKYRRYVIMTASTGVAAQLLPRGMTVHKAFSIPLDVLDVNKIPSISGGSVMAQRIRKSEAIIIDEISMLHKNVLRMVNEACKNVEANNETRKLPFAGKVILLGGDFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A7T2</accession>
    <name>A0A5N4A7T2_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PPYR_13006</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">1611_PpyrPB1</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A7T2"/>
    <dbReference type="InParanoid" id="A0A5N4A7T2"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11056">
        <property type="entry name" value="CYP6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000182">
        <property type="entry name" value="Cytochrome P450 3A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050476">
        <property type="entry name" value="Insect_CytP450_Detox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292:SF54">
        <property type="entry name" value="CYP9F3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0492">Microsome</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAB0793386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="352" mass="40673" checksum="4214EBFE265E60FB" modified="2020-02-26" version="1">MFHTILECSAQVVASLKKSGKEIVEFDVKELFGRLTTDVFFGTHFGILCNSVEEQTNEFYTIGQKATNFLGFWLKVRFIVIQVFPIVARVFGLRIFDQNVTNFFRLLVKNNIKSRKSQQIARPDLIGIIMKSENNPDNIELTDEILTALVATFFGAGFDTVSSALMYTFYELSCNSVVQQKLLDEIDANKDNFTYQTVMEMQYLNMVVSETLRKWPVGFFLERQCVKPYRIPALKDDEVEVQLKVGDGIWVPLYALHRDPELFSDPDRFDPERFNPENKKNINQYAYMPFGNGPRGCIGSRYALLVLKVAIFQILQSFSVRPSKNMLPLQIARSYLQLLPKDKMLLDFRRRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A9W0</accession>
    <name>A0A5N4A9W0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chitin-binding type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_13723</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0794103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A9W0"/>
    <dbReference type="InParanoid" id="A0A5N4A9W0"/>
    <dbReference type="OrthoDB" id="6597859at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024400006" description="Chitin-binding type-2 domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0794103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="221" mass="23684" checksum="D185199A10DDF852" modified="2020-02-26" version="1">MKSSILAIVVAMLTTVADGYLDYRGLLSRAEANETCQDAGRLGLACSSCNEIGRCLCNSDGRNCTITGYQPCPAGRICKQGRCVVGSICTPEKPPEFLCSSPGMFPDPYDCKAYYFCAPCDGTVLKAVRVACGEDLATGTKYGYNPATYVCSNRLTNGECTTLPIPVCKRPFEMGVVGGNSNLYYTCLNVTVGNQMTSTLYPYQDACELGRRYNVATGTCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AAP6</accession>
    <name>A0A5N4AAP6_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_11232</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0794393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AAP6"/>
    <dbReference type="InParanoid" id="A0A5N4AAP6"/>
    <dbReference type="OrthoDB" id="6700395at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024329427" evidence="2">
        <location>
            <begin position="23"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="95"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0794393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="224" mass="24605" checksum="0B64C3BE629233A2" modified="2020-02-26" version="1">MKRFTITCVCVISFLLVDPIYNAPSPRHRNRDRSSTTFDQTQSGDYNVQLHLKDFHIIAVLGDDSWGSLGDYDYNYDYSDLTIKPIVPATSEQPPASSSVSPDMESSPNDVSNATSTTKVSSEQQSSTESVLSSTTPKPIETTKSEPITNVSLIPVKIITDGDSDHPLPPGEILHYRKCTEGYSRDAQGRCRKIVRKSSQLPFGITRFAASLASKIRRIGSATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ADJ6</accession>
    <name>A0A5N4ADJ6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PPYR_12220</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">Phagosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Early endosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0795381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ADJ6"/>
    <dbReference type="FunCoup" id="A0A5N4ADJ6">
        <property type="interactions" value="1161"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4ADJ6"/>
    <dbReference type="OrthoDB" id="7862313at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030670">
        <property type="term" value="C:phagocytic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052745">
        <property type="term" value="F:inositol phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09093">
        <property type="entry name" value="INPP5c_INPP5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04380">
        <property type="entry name" value="RhoGAP_OCRL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.555.10:FF:000012">
        <property type="entry name" value="Putative inositol polyphosphate 5-phosphatase OCRL-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000004">
        <property type="entry name" value="Type II inositol 1,4,5-trisphosphate 5-phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031896">
        <property type="entry name" value="INPP5B_PH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046985">
        <property type="entry name" value="IP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048869">
        <property type="entry name" value="OCRL-1_2_ASH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037793">
        <property type="entry name" value="OCRL1/INPP5B_INPP5c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047078">
        <property type="entry name" value="RhoGAP_OCRL1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200:SF300">
        <property type="entry name" value="TYPE II INOSITOL 1,4,5-TRISPHOSPHATE 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16776">
        <property type="entry name" value="INPP5B_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21310">
        <property type="entry name" value="OCRL-like_ASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="9">
        <location>
            <begin position="660"/>
            <end position="836"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0795381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="840" mass="96345" checksum="1B8B68A4C1086C64" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AF82</accession>
    <name>A0A5N4AF82_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histone H2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PPYR_09949</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the histone H2A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0795888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AF82"/>
    <dbReference type="InParanoid" id="A0A5N4AF82"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 4" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histone H2A C-terminal" evidence="5">
        <location>
            <begin position="37"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0795888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="146" mass="16430" checksum="D9A4F1100C00B665" modified="2020-02-26" version="1">MEYLAAEVLELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLSGVTIAQVSPPKDRPSQASLQSLNCYLEVSNLISLGHLQQKVKMKNSHTSSSFKICINRRRTQDVHNTIFLPPFRCSLPPEVECNCISPITVLARTALTKKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AFN2</accession>
    <name>A0A5N4AFN2_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PPYR_10182</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CSN1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AFN2"/>
    <dbReference type="InParanoid" id="A0A5N4AFN2"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15852">
        <property type="entry name" value="SNARE_Syntaxin8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000021">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000039">
        <property type="entry name" value="Ubiquinol-cytochrome c reductase core subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048624">
        <property type="entry name" value="CSN1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019585">
        <property type="entry name" value="Rpn7/CSN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045135">
        <property type="entry name" value="Rpn7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041875">
        <property type="entry name" value="Syntaxin-8_SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14145">
        <property type="entry name" value="26S PROTESOME SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14145:SF2">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21151">
        <property type="entry name" value="CSN1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10602">
        <property type="entry name" value="RPN7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0736">Signalosome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1122"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="domain" description="PCI" evidence="12">
        <location>
            <begin position="262"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="11">
        <location>
            <begin position="1053"/>
            <end position="1115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAB0796121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1141" mass="126762" checksum="9979C77DC60357B0" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AGF1</accession>
    <name>A0A5N4AGF1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">phospholipase A2</fullName>
            <ecNumber evidence="1">3.1.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PPYR_10444</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15801"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:15802"/>
        </physiologicalReaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.4" evidence="1"/>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AGF1"/>
    <dbReference type="FunCoup" id="A0A5N4AGF1">
        <property type="interactions" value="1220"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AGF1"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047499">
        <property type="term" value="F:calcium-independent phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052816">
        <property type="term" value="F:long-chain fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000304">
        <property type="term" value="P:positive regulation of ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07212">
        <property type="entry name" value="Pat_PNPLA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047148">
        <property type="entry name" value="PLPL9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24139:SF34">
        <property type="entry name" value="85_88 KDA CALCIUM-INDEPENDENT PHOSPHOLIPASE A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24139">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="5 8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="221"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="348"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="PNPLA" evidence="9">
        <location>
            <begin position="469"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="8">
        <location>
            <begin position="473"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="8">
        <location>
            <begin position="505"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="8">
        <location>
            <begin position="638"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="507"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0796383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="792" mass="87367" checksum="A01E4C21F6C58EE1" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AGT2</accession>
    <name>A0A5N4AGT2_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fatty acid synthase</fullName>
            <ecNumber evidence="1">2.3.1.85</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PPYR_10641</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">1611_PpyrPB1</strain>
            <tissue evidence="20">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>acetyl-CoA + n malonyl-CoA + 2n NADPH + 2n H(+) = a long-chain fatty acid + (n+1) CoA + n CO2 + 2n NADP(+).</text>
            <dbReference type="EC" id="2.3.1.85"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.85" evidence="1"/>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AGT2"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08954">
        <property type="entry name" value="KR_1_FAS_SDR_x"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.180.10:FF:000015">
        <property type="entry name" value="Fatty acid synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000209">
        <property type="entry name" value="Polyketide synthase Pks12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049391">
        <property type="entry name" value="FAS_pseudo-KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF7">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21149">
        <property type="entry name" value="FAS_pseudo-KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="11" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-0521">NADP</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="18">
        <location>
            <begin position="13"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="18">
        <location>
            <begin position="881"/>
            <end position="1286"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="19">
        <location>
            <begin position="1709"/>
            <end position="1987"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="17">
        <location>
            <begin position="2837"/>
            <end position="2913"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="16">
        <location>
            <begin position="1709"/>
            <end position="1834"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="16">
        <location>
            <begin position="1849"/>
            <end position="1987"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="16">
        <location>
            <position position="1745"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="16">
        <location>
            <position position="1898"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAB0796580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="2913" mass="318792" checksum="3CAE19E4DFD026D0" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AGZ3</accession>
    <name>A0A5N4AGZ3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Malate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_10655</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LDH2/MDH2 oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AGZ3"/>
    <dbReference type="InParanoid" id="A0A5N4AGZ3"/>
    <dbReference type="OrthoDB" id="7881616at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1530.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.60">
        <property type="entry name" value="Hypothetical oxidoreductase yiak, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043144">
        <property type="entry name" value="Mal/L-sulf/L-lact_DH-like_ah"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043143">
        <property type="entry name" value="Mal/L-sulf/L-lact_DH-like_NADP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036111">
        <property type="entry name" value="Mal/L-sulfo/L-lacto_DH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003767">
        <property type="entry name" value="Malate/L-lactate_DH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11091:SF0">
        <property type="entry name" value="MALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11091">
        <property type="entry name" value="OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02615">
        <property type="entry name" value="Ldh_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89733">
        <property type="entry name" value="L-sulfolactate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0796594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="384" mass="41545" checksum="75EE9F4BCAFB6B0F" modified="2020-02-26" version="1">MAISYFRLFAARLLPETIQIRARTMSADTPETPIIPLKEARRFIVECLEAVGTPRIHASLQADLLVEADYRGHYSHGMNRLQIYIDDINAKTCDPKAVPKILQETPATAWVDGQNALGAVVGNFCMEAAIKKAKTVGVGWVCAKGSNHYGIAGMYALQAMRQGLLGMSFTNSSPFMCPTRGKQAALGTNPICLAAPAKGDDNFILDMATTAVAVGKIEIQRRKEALIPEGWAQDSEGKITTDPDVAYETGLLMPLGGPEINSGYKGFGLGMLVEIFCGILGGANYGSNIRKWGNATEVANLGQCFIAVDPNCFAPGFEDRMSDLMGNIRNCEPADPSIPVLVPGDPERNHMNFVDSVGGVRYVKNQMNTCKQLAEELHVKPLHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AHZ6</accession>
    <name>A0A5N4AHZ6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PPYR_10995</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AHZ6"/>
    <dbReference type="InParanoid" id="A0A5N4AHZ6"/>
    <dbReference type="OrthoDB" id="6773084at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd15489">
        <property type="entry name" value="PHD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1820">
        <property type="entry name" value="L1 transposable element, RRM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057251">
        <property type="entry name" value="FP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055197">
        <property type="entry name" value="PHDvar_NSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004244">
        <property type="entry name" value="Transposase_22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11505">
        <property type="entry name" value="L1 TRANSPOSABLE ELEMENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25298">
        <property type="entry name" value="Baculo_FP_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23004">
        <property type="entry name" value="PHDvar_NSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="7">
        <location>
            <begin position="2"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="116"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0796934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="330" mass="38302" checksum="447F7A3765E94786" modified="2020-02-26" version="1">MSEVCQKCTFNITSTQQKIKCVRCSKRYHINCMNPTIGELQYLKDNKEKWQCLTCIESNTKLRNTGSSSYYVPDEIPASVDVDPNDGQLNTSTALAHIIGQLKTVLEVQSETTTSINLCHEKIDELNNNFKKLSDAVTACEKNIEALETKNVILQRENSEIKEKLNELEQYTRKNIFEVYGVPESPGENIAVVVQAVANSIGFKLERWMIDTTHRLRKNANRPDQARGIIIKFVRRLDKEEFMRLKRVKRELKVSDLGSDFRNLIKQDNYIYVNDSLTVTNKILLNKAREFKKQNNVKYLWIRNGKIFMRVNEQSRVYEIKSSNDLRDVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AI11</accession>
    <name>A0A5N4AI11_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_11061</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0797000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AI11"/>
    <dbReference type="InParanoid" id="A0A5N4AI11"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0797000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="150" mass="17952" checksum="CBC1B7A58CBFD6DB" modified="2020-02-26" version="1">MVYYFMRTRVKICLLNDLRKDVVQNIQDEQEKSKLRYDKKRKPHVKYAEGEYVSIKRTGPSDISQKMEKKFIGPYLVKEVFDNDRYVIPDIPKYHMKQKPYQSVLPPERLKPWKAYEEETTSEESDDDEFHDNHESLDDQQPGCIEAMQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AI24</accession>
    <name>A0A5N4AI24_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein-cysteine N-palmitoyltransferase Rasp</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_11022</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the membrane-bound acyltransferase family. HHAT subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AI24"/>
    <dbReference type="FunCoup" id="A0A5N4AI24">
        <property type="interactions" value="220"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AI24"/>
    <dbReference type="OrthoDB" id="420606at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016409">
        <property type="term" value="F:palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051085">
        <property type="entry name" value="MB_O-acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13285">
        <property type="entry name" value="ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13285:SF18">
        <property type="entry name" value="PROTEIN-CYSTEINE N-PALMITOYLTRANSFERASE RASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="381"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="418"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="450"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0796961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="489" mass="57594" checksum="EA363FFBA6F5AAB2" modified="2020-02-26" version="1">MTLSNCERVVCCLIWIGGVLYSIYNVFLIRKEFTYLEDTYNDFAEGWLPQMPKKDVADFEWETVMKVFRTTAHYFIIHVVVSEYLRSYYIQLVPYWQSLISIIFLLQTVGLFGLLSILLQSVTFNYISLGKRKLVPWMTTGLWMTVVIYLKSAHCAEYLAKYFHFTEVQGYIVMLSLCWSNLRCLSYCLDDVQEKYKFVHFLSYCLYLPTLFIGPFIQFKDFNENFFGHQSTCLRERFWQLVVDLSRCIFWIFITEMSLHYFYINALAYQPEILQRMSNWALYGYGYCMGQFFHLKYVVFYGLSTSIAKFDHMKTPPLPKCIGRIHLYSDMWKYFDAGLYKFLVTYIYLPTLRTSQLYNKIFSSLLSFGFVYIWHGIEYNILIWTVINYIGICLENICNELVKLAPEVLNSSWRRRGLCILCSPLLAASAVSNFYFFAGSDVGNIFTHRIFQSSLMGNAALIFFLYGCCQLSLEVKHCEQNVYAKKKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AIE2</accession>
    <name>A0A5N4AIE2_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_08091</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AIE2"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050934">
        <property type="entry name" value="ITIH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013694">
        <property type="entry name" value="VIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10338">
        <property type="entry name" value="INTER-ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10338:SF108">
        <property type="entry name" value="INTER-ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN H4-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08487">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00609">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51468">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024458148" description="VWFA domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="1592"/>
        </location>
    </feature>
    <feature type="domain" description="VIT" evidence="3">
        <location>
            <begin position="30"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="297"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="VIT" evidence="3">
        <location>
            <begin position="859"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="1126"/>
            <end position="1339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0797097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1592" mass="176487" checksum="190A7288B3F00B82" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AIR2</accession>
    <name>A0A5N4AIR2_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Odorant receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PPYR_08226</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cell membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AIR2"/>
    <dbReference type="FunCoup" id="A0A5N4AIR2">
        <property type="interactions" value="13"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AIR2"/>
    <dbReference type="OrthoDB" id="6661390at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU351113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0797232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="346" mass="39686" checksum="1A41F97B8193B455" modified="2020-02-26" version="1">MIMYTFGIFIGFAKTLIIVRNRLKIGRMMDKLEEEPFTLNRKRGGDEEEALIKKCIWITNAQTYIYYGLGSITLTAGFLFTIIKRVSSNDFRDWEFAYGPITILNITYSPNYEISLCYQNLSIIWIGYHFVTADLLVADILVHISFQFKMLQNSFRRIVSNSLAKQVEDKCGPVKICDPTGQPIVQWKYLNQTLKETIRYHMAILDMADEMEELCSGLLLFVFISTLGMLCFIIYRASTLPFTDTQVLRNLFEGMSIALQVLIICFWGQEVANESESVAHSILESNFAGTDLRFQRALQLAMLRSQRATALTAGKFTSIGLPTFAWIMRTSYSAYMVVYNKNTKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AIV3</accession>
    <name>A0A5N4AIV3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Muscleblind-like CCCH zinc finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_08274</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AIV3"/>
    <dbReference type="InParanoid" id="A0A5N4AIV3"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043484">
        <property type="term" value="P:regulation of RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054429">
        <property type="entry name" value="Znf-CCCH_Muscleblind-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12675">
        <property type="entry name" value="MUSCLEBLIND-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12675:SF12">
        <property type="entry name" value="PROTEIN MUSCLEBLIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22628">
        <property type="entry name" value="zf-CCCH_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Muscleblind-like CCCH zinc finger" evidence="6">
        <location>
            <begin position="24"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="202"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="202"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF22628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0797280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="420" mass="44967" checksum="485FCFDE1B041281" modified="2020-02-26" version="1">MKNDATKWNKMFACFKSKASRKLEGRCNREKPPCKYFPPPQHLKDQLLINGRNHLALKNALMQQMGLTPGQPIVPGQVPAVAANPYLTGVPQVGSTYSPYFAPGPIMPTIVGPDPSGVASPLGVVPQTVVTQQKMPRSDRLEMDMKSVGSFYYENFAFPGMVPYKRPAADKSGVPVYQPNATTYQQLMQLQQPFVPVSCEYSASPTPAPTSSASPAAADIQQVPPTSQVSQVKEEDLIPPVSTPVTLPPPPIPDPAALAKEVAQQNYAKAVKLAAASQSLAASSLSHLNPLNYTGVALNKQAVGIPTTANIQRYPTLPLTLGAATNLNIGIHPYALTHTNLLNMSRPPSTLNYPYSLIRAPYPATTTPQLLTPNLLTAQYPVSVAATPITNVPPPTHIAAAAAQNNNNTVVQPYKKLKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AJG7</accession>
    <name>A0A5N4AJG7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_08464</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S51 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AJG7"/>
    <dbReference type="InParanoid" id="A0A5N4AJG7"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005320">
        <property type="entry name" value="Peptidase_S51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20842:SF0">
        <property type="entry name" value="ALPHA-ASPARTYL DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20842">
        <property type="entry name" value="PROTEASE S51 ALPHA-ASPARTYL DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03575">
        <property type="entry name" value="Peptidase_S51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024284954" description="Peptidase S1 domain-containing protein" evidence="5">
        <location>
            <begin position="18"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="6">
        <location>
            <begin position="93"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0797471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="421" mass="47030" checksum="8422FB847F2B534B" modified="2020-02-26" version="1">MNSAWISFILLIGNALGCDKTNCVTLSLCPALQRYVTNPVTNLALRNVEKLICEIDEDVRICCDQMAIANLQKESKSFYDNTKTCGIQDPTYEFPWMVGLFAFGRPLCSGALLNERYVLTSASCISYNGSLDLFSILLGDLNLKSNSCNQTNYATKECIQMKFLSVEETIPHPLFNGTFNNVGLIRLNESVVYTDYIQPICLPEATSNWPAMNSMYTSAFNFDPKTEREKFKRTTTVILKPLDMCREWYKSHGHTITLNELNFCSIDKDDTPPAFASTVVDCGAPVVTFHNNIWVLHEGLIYLGSSAGTNVATRGIHTTNDMPIVYPPSLDALKLVPFNINPHYLDADPNSVHKGETREERILQYQELPEAGVVVGLREGSMLLIENETMTLKGISKSRLFIPGEDPREIDVGADISYLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AKA3</accession>
    <name>A0A5N4AKA3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA repair endonuclease XPF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PPYR_08763</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AKA3"/>
    <dbReference type="FunCoup" id="A0A5N4AKA3">
        <property type="interactions" value="1857"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AKA3"/>
    <dbReference type="OrthoDB" id="361020at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000110">
        <property type="term" value="C:nucleotide-excision repair factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901255">
        <property type="term" value="P:nucleotide-excision repair involved in interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20078">
        <property type="entry name" value="XPF_nuclease_XPF_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10130:FF:000002">
        <property type="entry name" value="DNA repair endonuclease XPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006166">
        <property type="entry name" value="ERCC4_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006167">
        <property type="entry name" value="XPF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047520">
        <property type="entry name" value="XPF_nuclease"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00596">
        <property type="entry name" value="rad1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10150">
        <property type="entry name" value="DNA REPAIR ENDONUCLEASE XPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10150:SF0">
        <property type="entry name" value="DNA REPAIR ENDONUCLEASE XPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02732">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00891">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERCC4" evidence="13">
        <location>
            <begin position="659"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="885"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="454"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="896"/>
            <end position="906"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00072370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAB0797770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="906" mass="104443" checksum="E1A27568E3AB3D56" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ALD6</accession>
    <name>A0A5N4ALD6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PPYR_09143</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">1611_PpyrPB1</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ALD6"/>
    <dbReference type="InParanoid" id="A0A5N4ALD6"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11056">
        <property type="entry name" value="CYP6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000042">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050476">
        <property type="entry name" value="Insect_CytP450_Detox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292:SF54">
        <property type="entry name" value="CYP9F3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0492">Microsome</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024385689" description="Cytochrome P450" evidence="15">
        <location>
            <begin position="21"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="471"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAB0798150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="529" mass="60101" checksum="88AB3A9311AF9B4A" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AMT5</accession>
    <name>A0A5N4AMT5_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_09620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AMT5"/>
    <dbReference type="InParanoid" id="A0A5N4AMT5"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0798627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="63" mass="7497" checksum="EF418EA54ECC7995" modified="2020-02-26" version="1" fragment="single">LLKCGIQDLYNFGMLDAENGKMLNGKLFAVFEDLIKVFVKSWKQQREELERKRLEEQSLYKIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ANH1</accession>
    <name>A0A5N4ANH1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Putative nuclease HARBI1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Harbinger transposase-derived nuclease</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PPYR_06760</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Transposase-derived protein that may have nuclease activity. Does not have transposase activity.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HARBI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0798880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ANH1"/>
    <dbReference type="InParanoid" id="A0A5N4ANH1"/>
    <dbReference type="OrthoDB" id="6757375at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026103">
        <property type="entry name" value="HARBI1_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF289">
        <property type="entry name" value="DDE TNP4 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02086">
        <property type="entry name" value="PUTNUCHARBI1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="13">
        <location>
            <begin position="155"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAB0798880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="266" mass="30623" checksum="6E0420C62D5C6A26" modified="2020-02-26" version="1">MELIDVDDVDVVDMVDIVENIRIPRQIHIRRNLFNIYSNVEFFRRFRLEKGTALYLLEKIEHRLEYFHNRNNSISPMNQLLLTLRAYASAGHFVAVGDFVHADKSTVCKIVSKVSRLIASIAREFIYMPRNEVEIASAQNKFYDIAGFPRVIGAIDGCHIKIQSQGGADAEIYRNRKGYFSVNVQAVTSADLLFQDIVARWPGSTHDTTIFRNSRLMHRFNNGDFGNSILLGDSGYMNLSYLFTPFLNVQNDGERNYNRSHVQSRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ANS7</accession>
    <name>A0A5N4ANS7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Translation factor GUF1 homolog, mitochondrial</fullName>
            <ecNumber evidence="8">3.6.5.n1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Elongation factor 4 homolog</fullName>
            <shortName evidence="8">EF-4</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">GTPase GUF1 homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Ribosomal back-translocase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PPYR_06882</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.n1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion inner membrane</location>
            <topology evidence="8">Peripheral membrane protein</topology>
            <orientation evidence="8">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the GTP-binding elongation factor family. LepA subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.n1" evidence="8"/>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ANS7"/>
    <dbReference type="FunCoup" id="A0A5N4ANS7">
        <property type="interactions" value="1793"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4ANS7"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097177">
        <property type="term" value="F:mitochondrial ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03699">
        <property type="entry name" value="EF4_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16260">
        <property type="entry name" value="EF4_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01890">
        <property type="entry name" value="LepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03709">
        <property type="entry name" value="lepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000078">
        <property type="entry name" value="Elongation factor 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000015">
        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000007">
        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2570:FF:000001">
        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000004">
        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2570">
        <property type="entry name" value="Elongation factor 4, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00071">
        <property type="entry name" value="LepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006297">
        <property type="entry name" value="EF-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038363">
        <property type="entry name" value="LepA_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013842">
        <property type="entry name" value="LepA_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035654">
        <property type="entry name" value="LepA_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01393">
        <property type="entry name" value="lepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43512:SF7">
        <property type="entry name" value="TRANSLATION FACTOR GUF1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43512">
        <property type="entry name" value="TRANSLATION FACTOR GUF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06421">
        <property type="entry name" value="LepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="9">
        <location>
            <begin position="50"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="59"/>
            <end position="66"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="124"/>
            <end position="128"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="172"/>
            <end position="175"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0799002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="643" mass="72120" checksum="681F11E3271C8A61" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-09-13" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4APA4</accession>
    <name>A0A5N4APA4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tyr recombinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_07062</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4APA4"/>
    <dbReference type="InParanoid" id="A0A5N4APA4"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0799182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="249" mass="28681" checksum="103B66F2181DFE78" modified="2020-02-26" version="1">MNTLPKFVQENAQKATETLLPLKSKEKYEKEFETFTAWQSKHKIFTINETVLLSYFQELSEKYTPTSLWTKYSLLKSTFIVKKKTDISNYNQLIYFLKVKSEVKSKGYIPKKSQVLTGDQVFEFIKRAPNDIYLLHKVVLVMGVFGGLRRDEMVKMYDHLELSSSISDKNINVPGLSNKNITFSGKFENYDHLELSSSISDKNINVPGLSNKNITFSGKFENCNFHIGGLKRRTSASERVKSDYLPQRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4APK0</accession>
    <name>A0A5N4APK0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sulfatase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PPYR_07162</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sulfatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4APK0"/>
    <dbReference type="InParanoid" id="A0A5N4APK0"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16029">
        <property type="entry name" value="4-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047115">
        <property type="entry name" value="ARSB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10342">
        <property type="entry name" value="ARYLSULFATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10342:SF273">
        <property type="entry name" value="RE14504P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00149">
        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase N-terminal" evidence="7">
        <location>
            <begin position="30"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0799282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="544" mass="61389" checksum="0C678657C369C71A" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AQB0</accession>
    <name>A0A5N4AQB0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MBD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_07397</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AQB0"/>
    <dbReference type="InParanoid" id="A0A5N4AQB0"/>
    <dbReference type="OrthoDB" id="61560at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00122">
        <property type="entry name" value="MBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15489">
        <property type="entry name" value="PHD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.890.10">
        <property type="entry name" value="Methyl-cpg-binding Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016177">
        <property type="entry name" value="DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052283">
        <property type="entry name" value="GenomicStab_NeuMorph_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001739">
        <property type="entry name" value="Methyl_CpG_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15739:SF5">
        <property type="entry name" value="LD23158P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15739">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01429">
        <property type="entry name" value="MBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00391">
        <property type="entry name" value="MBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54171">
        <property type="entry name" value="DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50982">
        <property type="entry name" value="MBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MBD" evidence="2">
        <location>
            <begin position="254"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="343"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="525"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="688"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="551"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="566"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="741"/>
            <end position="755"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0799517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1202" mass="133655" checksum="6EBFAAC1B79FAEC4" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AQG3</accession>
    <name>A0A5N4AQG3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PPYR_07416</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AQG3"/>
    <dbReference type="InParanoid" id="A0A5N4AQG3"/>
    <dbReference type="OrthoDB" id="10253869at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046949">
        <property type="term" value="P:fatty-acyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000007">
        <property type="entry name" value="4-coumarate--CoA ligase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF422">
        <property type="entry name" value="BCDNA.GH02901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="4">
        <location>
            <begin position="43"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="5">
        <location>
            <begin position="470"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0799536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="554" mass="61670" checksum="0B8A34A092C49DCC" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AQV6</accession>
    <name>A0A5N4AQV6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF5641 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_07590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AQV6"/>
    <dbReference type="InParanoid" id="A0A5N4AQV6"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040676">
        <property type="entry name" value="DUF5641"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008042">
        <property type="entry name" value="Retrotrans_Pao"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18701">
        <property type="entry name" value="DUF5641"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05380">
        <property type="entry name" value="Peptidase_A17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5641" evidence="1">
        <location>
            <begin position="222"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0799710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="271" mass="30293" checksum="0AAD227B5440C208" modified="2020-02-26" version="1">MTNVTNLILNLNHDESLKTLGVGWAPSSDLVQYNAHMNSTRSIVTKRFILANVSQIFDPLGLVGPVTAIAKLLMQDIWKLRIGWDVELSQNLKHRWEEISSQLLTIGVIKIPRCVATDPTSSLELHGFSDASVRAYGACIYIREILLDNSVRCQLLCAKSRIASLKTLTLPKLELCAALLLTDLFSDFIFNKFSTFETLIRVAAFCKRFINNCRDKSKKAVEDNAPSRHWKLGRVTKVHPGPDNVVRAATIKTSHGEVKRPSVRLCVLPTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AQZ1</accession>
    <name>A0A5N4AQZ1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF5641 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_07609</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AQZ1"/>
    <dbReference type="InParanoid" id="A0A5N4AQZ1"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040676">
        <property type="entry name" value="DUF5641"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF2">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18701">
        <property type="entry name" value="DUF5641"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5641" evidence="1">
        <location>
            <begin position="119"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0799729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="218" mass="25338" checksum="92BEA9021EEAB4CF" modified="2020-02-26" version="1">MFEFLNKNADQFKKSLIYEGNKWHFSPASSPHFNGLAEAGVKSTKFHLKRVLGYALLTYEEYLTVIVEIECLLNSRPLYPLSSSPNDYQVLTPSHFLIGRRLTAIPNTDFVEIPTNRLSRWQYLSKLQQQFWNRWSRDYLGDLQIRTKWNIAQDNVKPGTIVLIKENNTPPAHWKIGRVIEVHPGDDNIIRVATIKTKSGLYKRAVRTKSLLTKYEMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ARN9</accession>
    <name>A0A5N4ARN9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PPYR_07758</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ARN9"/>
    <dbReference type="FunCoup" id="A0A5N4ARN9">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4ARN9"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF269">
        <property type="entry name" value="NUCLEASE HARBI1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
        <property type="entry name" value="HTH_psq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE-1" evidence="8">
        <location>
            <begin position="5"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="HTH psq-type" evidence="9">
        <location>
            <begin position="264"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="DDE Tnp4" evidence="10">
        <location>
            <begin position="461"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0799878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="691" mass="79584" checksum="CCAB9D87AA9BCB4B" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ARR9</accession>
    <name>A0A5N4ARR9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ras-GEF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_07788</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ARR9"/>
    <dbReference type="InParanoid" id="A0A5N4ARR9"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF368">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-GEF" evidence="4">
        <location>
            <begin position="475"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="181"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="183"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0799908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="750" mass="86353" checksum="99C007FDAB7EDD89" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ASP7</accession>
    <name>A0A5N4ASP7_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_06125</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000004">
        <property type="protein sequence ID" value="KAB0800385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ASP7"/>
    <dbReference type="InParanoid" id="A0A5N4ASP7"/>
    <dbReference type="OrthoDB" id="6262491at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034274">
        <property type="term" value="C:Atg12-Atg5-Atg16 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000421">
        <property type="term" value="C:autophagosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045160">
        <property type="entry name" value="ATG16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19878">
        <property type="entry name" value="AUTOPHAGY PROTEIN 16-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19878:SF8">
        <property type="entry name" value="AUTOPHAGY-RELATED 16, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="134"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0800385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="204" mass="22440" checksum="4A113EDE5DB91656" modified="2020-02-26" version="1">MAGKFLGEQTKVVTGSYDRTLKIWDLRSRACIGTKFAGSSCNDLVTVDGAGTTFISGHFDKTVRFWDIRSDYPTHDMCLQGKVTSLDLSRDSNYLISCVRDDTLKLIDLRMNQIILSFSCDDFKVGCDWSRATFSPDGQYVAVGSADGSVFIWGVATAKVETVLKDHGSVGLFSRSAVTATSWNPFGTYLISVDRSKRAVVWGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ATQ0</accession>
    <name>A0A5N4ATQ0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Acyltransferase</fullName>
            <ecNumber evidence="11">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PPYR_06460</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the diacylglycerol acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="11"/>
    <dbReference type="EMBL" id="VVIM01000004">
        <property type="protein sequence ID" value="KAB0800721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ATQ0"/>
    <dbReference type="FunCoup" id="A0A5N4ATQ0">
        <property type="interactions" value="110"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4ATQ0"/>
    <dbReference type="OrthoDB" id="264532at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004144">
        <property type="term" value="F:diacylglycerol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07987">
        <property type="entry name" value="LPLAT_MGAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007130">
        <property type="entry name" value="DAGAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12317:SF79">
        <property type="entry name" value="ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12317">
        <property type="entry name" value="DIACYLGLYCEROL O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03982">
        <property type="entry name" value="DAGAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="21"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAB0800721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="333" mass="37843" checksum="C5BA9FF8E5E9DCCE" modified="2020-02-26" version="1">MDNATSYFRKVPEKIYVAMPLFSMWFGSVLSAAVLVYVAFFTYVWPLLLVYIVWIYTIDKDTCDRGGRSNTWLRICYCFPRGLNYFPMKFINVAKAPLNAKRNYLFCCFPHGVMPLGVAGAFLTDYGGFDECFPNHIRRLATLRHFFSIPFYREYLLSAGQCSASENSLNYMLSYPGGGNIVGLTVGGAEEALYAKPGNYYVVLKKRKGFIRVALRNGSPLVPVFSFGVIDIYDQMSNPYLKRLQNYVKSVTGVALILPIGCGFLQDWFGILPKSRPITTIVGDPIEVSRIENPSQNQIEDLHSRFVEQLEKLFNDHKHSYVRDADNVKLIIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AWM8</accession>
    <name>A0A5N4AWM8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Adenylate kinase 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_03826</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0801640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AWM8"/>
    <dbReference type="InParanoid" id="A0A5N4AWM8"/>
    <dbReference type="OrthoDB" id="522106at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019205">
        <property type="term" value="F:nucleobase-containing compound kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22979">
        <property type="entry name" value="DD_AK8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0801640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="467" mass="54096" checksum="92379856CF837D9B" modified="2020-02-26" version="1">MSDGLRRKLTMPPWHIPYLEKHRIYDLFHELARELVIQQPVDHVLFMKQVLEHAAKNINVARVVLLSSPKINLYEVALEISYYTQQTIVNENTIVEELNREKERSQLTPQELAKCLDKIVRRRQVKGWILIDCIKNACEAKAMLQHGILPTHVIHLIPPFEPPLNNAIYSSVQEGWPEYRRSIMSVRDVFKHCLIEVHLGEKSIEEVVEECYEHIKIQKGFGGPKQPRIVILGPRGCGRKTQARLLEENLNVIHVDFEYLLCQAWISKTELGKKLRECQDDVCFQTNLLMKVLDQRILKKDCLDQGWVLTGFPFTVNDFRYLDCLDTPPNRVIFIDCDLRVCRERILNRKINVHTGSVTNLMDNRDLVIQKLLATHPKDNIDALEAELKYYCEHYGSLKKYCGQTATVINGNQPQRWVYESICAIIVRAAPACPPRNPCKLDTDDFMCLDPCMCADDLLPKSYMHLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AWX7</accession>
    <name>A0A5N4AWX7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein sleepless</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_04048</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0801862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AWX7"/>
    <dbReference type="FunCoup" id="A0A5N4AWX7">
        <property type="interactions" value="15"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AWX7"/>
    <dbReference type="OrthoDB" id="6415465at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00117">
        <property type="entry name" value="TFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051110">
        <property type="entry name" value="Ly-6/neurotoxin-like_GPI-ap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045860">
        <property type="entry name" value="Snake_toxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16983:SF10">
        <property type="entry name" value="PROTEIN QUIVER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16983">
        <property type="entry name" value="UPAR/LY6 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57302">
        <property type="entry name" value="Snake toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0801862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="169" mass="19122" checksum="D54854930E396491" modified="2020-02-26" version="1">MIVKYGVYVCILIMSAFEMLYAYAGELTDSEHRTKAATEKLPTLVCYRCNTMTDNEKCLDLHNNSTSFHANCSDDSRICQVKRISMTTITKTGEVTGTPKLWMLQRNCTGTCDPGCIIIGERTKLYSCTTCCEESYCNHGNSASSFYIEHFQVLLYHLYTVLLMLIVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AXY7</accession>
    <name>A0A5N4AXY7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_04385</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AXY7"/>
    <dbReference type="FunCoup" id="A0A5N4AXY7">
        <property type="interactions" value="6"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AXY7"/>
    <dbReference type="OrthoDB" id="2261376at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17317">
        <property type="entry name" value="MFS_SLC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="227"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="340"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="370"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="398"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="483"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="92"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0802199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="565" mass="63660" checksum="D68539EFF5AD5414" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AYI9</accession>
    <name>A0A5N4AYI9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">28S ribosomal protein S18c, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_04572</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bS18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AYI9"/>
    <dbReference type="FunCoup" id="A0A5N4AYI9">
        <property type="interactions" value="805"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AYI9"/>
    <dbReference type="OrthoDB" id="10066799at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.640.10">
        <property type="entry name" value="Ribosomal protein S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001648">
        <property type="entry name" value="Ribosomal_bS18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036870">
        <property type="entry name" value="Ribosomal_bS18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13479">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13479:SF40">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS18M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01084">
        <property type="entry name" value="Ribosomal_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46911">
        <property type="entry name" value="Ribosomal protein S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0802386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="135" mass="15639" checksum="E8B880F49B1573FC" modified="2020-02-26" version="1">MFSYAILRSKLPSTTRLWTPMVRLLTSTSNSTNVPLFDMENPFEKEKRKCILCQHNVIPNYKNVKLLSQFQSPYTGRIYGKHITGLCAEKQAQVELEISKAQKSGLMAVYLKEPCFIKDPKLFDSENPIRPHRFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B0B0</accession>
    <name>A0A5N4B0B0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MADF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_05169</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B0B0"/>
    <dbReference type="InParanoid" id="A0A5N4B0B0"/>
    <dbReference type="OrthoDB" id="9909584at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21505">
        <property type="entry name" value="MADF DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21505:SF12">
        <property type="entry name" value="MADF DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00595">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51029">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MADF" evidence="2">
        <location>
            <begin position="10"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0802983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="275" mass="31167" checksum="C1230D091D8FD7FB" modified="2020-02-26" version="1">MGWSQEQVQALIECYRANECLYMVTSPLYKNKHARNAALQNIAECLKSMGRNVTIPEIKVKWNGLRTNYLSELRKYESTQKSGAGADDILKPSLWYFDIMRFIDKYITPRKSTDVLDITAATVDIDNGSDDIDHGNDVIIEYIDESDIETINSNISSPATSLLPTDDTQTVGSFIPNKKKISSNENIPSTPSVRPSKKVRKEDKLAEEQALTLGAIRTANEQRKPTPTYNSPFSNYVAFRLNSITDDTIRATAEEEIMEVIFRNYKIFINKQHNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B0H7</accession>
    <name>A0A5N4B0H7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">UPAR/Ly6 domain-containing protein qvr</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Protein quiver</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Protein sleepless</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PPYR_00069</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">1611_PpyrPB1</strain>
            <tissue evidence="19">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Bifunctional regulator of neuronal activity in the mushroom body, and possibly other regions of the brain, that acts as a signaling molecule required for homeostatic regulation of sleep under normal conditions and after sleep deprivation. Reduces neuronal excitability by enhancing Sh/shaker K(+) channel activity; possibly by stabilizing Sh/shaker to increase protein levels, accelerating its activation kinetics, slowing C-type inactivation and enhancing recovery from inactivation. Specifically affects the A-type K(+) current. Antagonizes nicotinic acetylcholine receptors (nAChRs) to reduce synaptic transmission, possibly by preventing their localization to the cell surface. Required for regulation of neuromuscular excitability and plasticity at neuromuscular junctions.</text>
    </comment>
    <comment type="subunit">
        <text evidence="18">Interacts (via loop 2 of the three-fingered Ly-6 domain) with Sh/shaker; this interaction may stabilize both components of the complex and may be required for targeting or retention of Sh/shaker to neural cell projections. Interacts (via loop 2 of the three-fingered Ly-6 domain) with nAChRalpha3 and potentially other nicotinic acetylcholine receptors; this interaction is required for antagonism of nicotinic acetylcholine receptors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
            <orientation evidence="1">Extracellular side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Membrane raft</location>
            <topology evidence="14">Lipid-anchor</topology>
            <topology evidence="14">GPI-anchor</topology>
            <orientation evidence="14">Extracellular side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the quiver family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B0H7"/>
    <dbReference type="InParanoid" id="A0A5N4B0H7"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032222">
        <property type="term" value="P:regulation of synaptic transmission, cholinergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048511">
        <property type="term" value="P:rhythmic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030431">
        <property type="term" value="P:sleep"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23595">
        <property type="entry name" value="TFP_LU_ECD_Qvr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031424">
        <property type="entry name" value="QVR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050975">
        <property type="entry name" value="Sleep_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33562">
        <property type="entry name" value="ATILLA, ISOFORM B-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33562:SF31">
        <property type="entry name" value="PROTEIN QUIVER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17064">
        <property type="entry name" value="QVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0090">Biological rhythms</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00044561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00045788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00046769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAB0803099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="132" mass="15787" checksum="CCFB41B3BD10C9C5" modified="2020-02-26" version="1">MIMCVTAKPINCYNCDSEYDVRCRDPFNWSSPEIHPPYISCNGCCIKWVLNSKTPKEIVRRSCITQYQVNLFMVDRGCMQERSKTGHLCFCEEDLCNRCKLNKLQKRLGKKFEYLLNYYKQSLIYILYYFLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-06-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B0Z7</accession>
    <name>A0A5N4B0Z7_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_00193</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B0Z7"/>
    <dbReference type="InParanoid" id="A0A5N4B0Z7"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0803223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="176" mass="20310" checksum="DF970A2B95AC86B7" modified="2020-02-26" version="1">MIVIPANDLQGSLINTSTTSYHHDITDSYDMFQPSTSKKTRSEDSFLFPSTLENLLKMHVDGKIIMAHKHKLNNDDRQKLAKIVVNQIISTHNYAEIRADTFLEAAKEIINLFPTEKIETYYIPYSPPKGSLRRQPARGKLWSRYVNVRAALRLADKYKVTDENKENLVLEEENDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B192</accession>
    <name>A0A5N4B192_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4218 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_00341</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B192"/>
    <dbReference type="InParanoid" id="A0A5N4B192"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33053">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33053:SF24">
        <property type="entry name" value="TRANSPOSASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0803371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="316" mass="36448" checksum="EA4477EFAB4C9F41" modified="2020-02-26" version="1" fragment="single">LAVRLRSQLVNVLSENLISLKSFIPVEINRKPRSLSELMRWKATEFRTFLLYLGPLVLLNVVDQAVYEHFLLLHVAVVLVMSEHHIAMFGSQLSSQLFNLFVTHSEHIYGNEFYVYNVHYLTHLHDDVEIFGVLDNFSAFPFENYLAQIKRLVKSPDNPLPQISRRLLEMSHSCDPCLGNLRNDETNHKFEHNSGPTAQLLCKQFKQITMDGFSFSIYSYSCADSYCLTKDKMVIRIENILLSSSRNTLIVCKEFKSYESFYNYPFNSNVIGIVKIKDLSLELKVITLKDITAKCIVLPTNTKDNSWISMPLIHTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2024-05-29" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B1K9</accession>
    <name>A0A5N4B1K9_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_00416</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B1K9"/>
    <dbReference type="InParanoid" id="A0A5N4B1K9"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0803446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="79" mass="9005" checksum="CB3D38A9CBDB1E11" modified="2020-02-26" version="1">MYQAKGYFSVFSSNMFLLYELPSLTELNCGGILCQSLRMVCKGLPPHPKTLLTKASSSWFFDHCVHCYHVSTHCLLIQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B1L4</accession>
    <name>A0A5N4B1L4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Malate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_00462</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LDH2/MDH2 oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B1L4"/>
    <dbReference type="InParanoid" id="A0A5N4B1L4"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1530.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.60">
        <property type="entry name" value="Hypothetical oxidoreductase yiak, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043144">
        <property type="entry name" value="Mal/L-sulf/L-lact_DH-like_ah"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043143">
        <property type="entry name" value="Mal/L-sulf/L-lact_DH-like_NADP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036111">
        <property type="entry name" value="Mal/L-sulfo/L-lacto_DH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003767">
        <property type="entry name" value="Malate/L-lactate_DH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11091:SF0">
        <property type="entry name" value="MALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11091">
        <property type="entry name" value="OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02615">
        <property type="entry name" value="Ldh_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89733">
        <property type="entry name" value="L-sulfolactate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0803492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="361" mass="39239" checksum="126F00E7CA738430" modified="2020-02-26" version="1">MEMNEDSQVVSLQECRRFITECMIAVGVPECHANAQSDLLVEADYRGHYSHGMNRLDHYVKDVQTEWTDKLAVPKVLAETPATAWVDGQNGLGAIVGNFCMGIAIKKAKNVGVGWVCARGANHYGIAGIYAMQAARFGLIGMSFTNTCPITNSTRSKKPAIGVNPLAFAASSSNDSFVLDMSTSTVAVGKIEMKKRKQEKLPEGWALDHEGNITDDPKVACEAQHLLPLGGTELNGGYKGFGLGVMVEMLTGILAGSNYADRIPPYNLFSKDRPRDLGQCFIAVDPKCFAPGFEDRLDDLLDSIRNLDPSNPEKPVIVAGDPEREHMAEVNRIGGIRFCKDQLESCSKLAASLKVAPLKFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B3S9</accession>
    <name>A0A5N4B3S9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Regulatory protein zeste</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PPYR_01239</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">1611_PpyrPB1</strain>
            <tissue evidence="19">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Involved in transvection phenomena (= synapsis-dependent gene expression), where the synaptic pairing of chromosomes carrying genes with which zeste interacts influences the expression of these genes. Zeste binds to DNA and stimulates transcription from a nearby promoter.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Self-associates forming complexes of several hundred monomers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4B3S9"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028002">
        <property type="entry name" value="Myb_DNA-bind_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021896">
        <property type="entry name" value="THAP9-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048365">
        <property type="entry name" value="TNP-like_RNaseH_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF292">
        <property type="entry name" value="DDE TNP4 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13873">
        <property type="entry name" value="Myb_DNA-bind_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21787">
        <property type="entry name" value="TNP-like_RNaseH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12017">
        <property type="entry name" value="Tnp_P_element"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 16" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="18">
        <location>
            <begin position="194"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="813"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="879"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="948"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="883"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="894"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="922"/>
            <end position="932"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00025466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAB0804269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1600" mass="182614" checksum="D07C1CCCF2E820DE" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B467</accession>
    <name>A0A5N4B467_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">N-acetylneuraminate lyase</fullName>
            <ecNumber evidence="5">4.1.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PPYR_01314</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>aceneuramate = aldehydo-N-acetyl-D-mannosamine + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:23296"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:17122"/>
            <dbReference type="ChEBI" id="CHEBI:173083"/>
            <dbReference type="EC" id="4.1.3.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-sugar metabolism; N-acetylneuraminate degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DapA family. NanA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.3" evidence="5"/>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B467"/>
    <dbReference type="InParanoid" id="A0A5N4B467"/>
    <dbReference type="OrthoDB" id="191315at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008747">
        <property type="term" value="F:N-acetylneuraminate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020624">
        <property type="entry name" value="Schiff_base-form_aldolases_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="DIHYDRODIPICOLINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128:SF21">
        <property type="entry name" value="N-ACETYLNEURAMINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00665">
        <property type="entry name" value="DHDPS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0704">Schiff base</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="12">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="12">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001365-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001365-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAB0804344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="311" mass="34063" checksum="F8E3556F8CE83C1D" modified="2020-02-26" version="1">MGHRKTATMLTYRGLMAPVFTPFKNDVHKTLNVDVIPSYADYCQKNGIKGILVNGTTGEGSSMTTKERKLVTEVWMEQCKSRKQHLMVQVGGISLPDVLSLAAHAEKTGADSILCLPELFQKPTSIADLIRYLKMVAKAAPNTPLLYYHIPRMTHVNIHMGTFLNSVGNSIPTFSGIKFSSTVLDEGLAAVKADKEKYCVFLGAHAIMAGAYTLGFSLGIATTQNIFPQFGETILKSIMKGQLLQAQETQADLNTAVNIINKYGPFVPSMKAAMQILSSVPVGETREPVTPVPVEQMKKMEIELRALPFIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B4F5</accession>
    <name>A0A5N4B4F5_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_01403</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B4F5"/>
    <dbReference type="InParanoid" id="A0A5N4B4F5"/>
    <dbReference type="OrthoDB" id="6796610at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="110"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0804433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="177" mass="19891" checksum="52AE4B4A01908D52" modified="2020-02-26" version="1">MDRFCSYCGARRQLEFDRPLDRCSKCDKFPFILSHEVKSASVLRCSVCTAYICAINRYCEICGHTVENSKRIRGERAGQMQMAGKIQAKKMEAIERRKRRKLEAECSSFSASTPSTMTSLSPSKKSSSNPLSFSSNDDEDVDNLLSQIPDSELSQIQDSQKPDSELSQIQDSEANPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B500</accession>
    <name>A0A5N4B500_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PPYR_01657</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A5N4B500">
        <property type="interactions" value="142"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4B500"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002512">
        <property type="entry name" value="Pebbled, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001788">
        <property type="entry name" value="ras-responsive element-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002095">
        <property type="entry name" value="ras-responsive element-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000682">
        <property type="entry name" value="ras-responsive element-binding protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001782">
        <property type="entry name" value="Ras-responsive element-binding protein 1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001289">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052795">
        <property type="entry name" value="RREB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46451">
        <property type="entry name" value="RAS-RESPONSIVE ELEMENT-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46451:SF1">
        <property type="entry name" value="RAS-RESPONSIVE ELEMENT-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="89"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="124"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="152"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="276"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="347"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="494"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="525"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="553"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="978"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="1212"/>
            <end position="1239"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="1375"/>
            <end position="1403"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="1444"/>
            <end position="1471"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="1472"/>
            <end position="1494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="451"/>
            <end position="476"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="769"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="999"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1161"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1323"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1413"/>
            <end position="1434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="13"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="64"/>
            <end position="78"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1000"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1172"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1339"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1421"/>
            <end position="1434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAB0804687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1584" mass="179813" checksum="ABE8AB962C0A685A" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B5I4</accession>
    <name>A0A5N4B5I4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed DNA polymerase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_01841</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B5I4"/>
    <dbReference type="InParanoid" id="A0A5N4B5I4"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511">
        <property type="entry name" value="PROTEIN CBG23764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511:SF12">
        <property type="entry name" value="RHO TERMINATION FACTOR N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="His-Me finger endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0804871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="718" mass="83435" checksum="EF6CE77709BEA403" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B6B9</accession>
    <name>A0A5N4B6B9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_02063</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0805093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B6B9"/>
    <dbReference type="InParanoid" id="A0A5N4B6B9"/>
    <dbReference type="OrthoDB" id="6592755at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd22343">
        <property type="entry name" value="PDDEXK_lambda_exonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051703">
        <property type="entry name" value="NF-kappa-B_Signaling_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019080">
        <property type="entry name" value="YqaJ_viral_recombinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46609">
        <property type="entry name" value="EXONUCLEASE, PHAGE-TYPE/RECB, C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46609:SF8">
        <property type="entry name" value="YQAJ VIRAL RECOMBINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09588">
        <property type="entry name" value="YqaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="2">
        <location>
            <begin position="70"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0805093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="455" mass="52228" checksum="30040E842F68E442" modified="2020-02-26" version="1">MENRFSICDYLLYIKGTDNSRVVYEGEHVLNAGHIILCGVTNKEENRLTLYALCLQTSALQSAPHKIEGTLVHDDEKWVVEKFACSCKAGQSGRCKHISAVLLQCSRTSLDKLEAVSQTDIKCTWSAQKGKTQDKYRAIPVKEMPCIKQSDGMKLDEAILMGIHDNLVSKLPNSALALHKAGRRCTNLSTFENEEVFTPYDEHDVVILNHATQSILMMELYHFHVNFIGSCCKELFDKHLLKDIDEILLKTKQSKEFWNIERKFRVTGSRIYELYTYKSDDWQKKANRYFNPISFMNKFTKHGIEQKPVARQIFMDATGLKVVECGLVVSHFNSWLGYSPDGIIVDQDGNPKELIEIKCPFAGATETIGSVVPKLKYLQLEDNIYELKKKHKYFAQVQLGMAMLNVFNCKFIIYCSFDKSMLILDVPYNYDFSKTLLFNVKGKYFKKMLHVMCNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B6T8</accession>
    <name>A0A5N4B6T8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_02050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0805080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B6T8"/>
    <dbReference type="InParanoid" id="A0A5N4B6T8"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052797">
        <property type="entry name" value="RegFact_GeneExpr_CellDeath"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33936:SF24">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33936">
        <property type="entry name" value="PROTEIN CBG17840"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="38"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="76"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0805080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="375" mass="44038" checksum="E6BEE741F9283605" modified="2020-02-26" version="1">MNSKKHHFLSIRNIRKHVINVVDKLEELAPLKTFKIGAVCNECDKTFVKYSSLTQHVKKYHNDKLSQLTKSKKYLFECEKCQKHFTHFRHFKYHKKIHEEKKTKGLRCILCKQESDAECFTKPDLFKHFKIRHDVDIITEQLYFTSLEEFKTWKKEKEKQSNELFVKPYGTDKNKKFTTTKYKCHRSGFYKSKGKHLRHLKTQGSKKINGYCPAEMSVTEIDARFEVEYVSTHVGHTSDLGHLTLNETERNKLAVQIAAKIPFETILDEVRESINGTLERCHLLTKKDLYNIERSLNLNKEARRHCNDAISVDAWVQEIRSTGCVLFYKAQGECCTDYPLLNNNDFALVIMNQGQHEMLDRYGDDCICIDETFGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B6U6</accession>
    <name>A0A5N4B6U6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BED-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_02297</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0805327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B6U6"/>
    <dbReference type="InParanoid" id="A0A5N4B6U6"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37162:SF6">
        <property type="entry name" value="BED-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37162">
        <property type="entry name" value="HAT FAMILY DIMERISATION DOMAINCONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="267"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0805327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="667" mass="75911" checksum="7CBFDF31A192612F" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B6V9</accession>
    <name>A0A5N4B6V9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_02307</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0805337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B6V9"/>
    <dbReference type="InParanoid" id="A0A5N4B6V9"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF74">
        <property type="entry name" value="POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="3">
        <location>
            <begin position="71"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0805337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="495" mass="56653" checksum="5461BD42D7BD447C" modified="2020-02-26" version="1">MTVKQAILEYFNGVYSEREAARVHSIKRSTLQSRVKKILTNKTKEQYLREQNLNDSGHESDIDDSPPKYSSKYTNRQVFSTQEELELEKYIKRCSDINYGLTYVQIQKLAYEFAIALPHCNFPQEWREAKQAKEGWLRGFMARHKSLALRKPESTSLSRSTAFNKHKVDQFFENLKKVLDKYKFPPEKIYNLDETGVTTVMKPVKIVSTSGKRQVSQAASAERGELVTFIGIINAAGQSIPPVYVFPRVRNIEDFMFDCPVSSLGLGNKSGWMTTELFPKVLQHIVAHTHCTVTEPILLLVDNHESHVNITSVRYCKENGIILLGFAPHTTHRMQPLDVGIYGPFKNYCNVTFNDWMTSNPGKTISVKHIPQLTKMPYLKAFTASNIINSFQKPGIYPFNRLAFTDEDFTPSYVTDQPLITEECKQNRGNENNEIQSQIISNETTPEKPQHADTSSASKKANAINQMNQNENDNRQTVETINQLGRYYKCRHAIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1JR63</accession>
    <name>A0A1Y1JR63_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">CCR4-NOT transcription complex subunit 4</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="23">CCR4-associated factor 4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="24">E3 ubiquitin-protein ligase CNOT4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Potential transcriptional repressor NOT4Hp</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">RING-type E3 ubiquitin transferase CNOT4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="32" type="ORF">PPYR_03282</name>
    </gene>
    <organism evidence="31">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="31" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="32 33" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="32">1611_PpyrPB1</strain>
            <tissue evidence="32">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="32" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="32">1611_PpyrPB1</strain>
            <tissue evidence="32">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Has E3 ubiquitin ligase activity, promoting ubiquitination and degradation of target proteins. Involved in activation of the JAK/STAT pathway. Catalyzes ubiquitination of methylated RBM15. Plays a role in quality control of translation of mitochondrial outer membrane-localized mRNA. As part of the PINK1-regulated signaling, upon mitochondria damage, ubiquitinates ABCE1 and thereby recruits autophagy receptors to the mitochondrial outer membrane to initiate mitophagy.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="19">Interacts with CNOT1 via its C-terminus but does not stably associate with the CCR4-NOT complex. Interacts (via RING domain) with UBE2D2. Interacts with ABCE1, PINK1 and PELO.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="EMBL" id="GEZM01102967">
        <property type="protein sequence ID" value="JAV51660.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01102966">
        <property type="protein sequence ID" value="JAV51661.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01102965">
        <property type="protein sequence ID" value="JAV51662.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01102964">
        <property type="protein sequence ID" value="JAV51663.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01102963">
        <property type="protein sequence ID" value="JAV51664.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1JR63"/>
    <dbReference type="FunCoup" id="A0A1Y1JR63">
        <property type="interactions" value="72"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1JR63"/>
    <dbReference type="OrthoDB" id="1923159at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030014">
        <property type="term" value="C:CCR4-NOT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16618">
        <property type="entry name" value="mRING-HC-C4C4_CNOT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12438">
        <property type="entry name" value="RRM_CNOT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000006">
        <property type="entry name" value="CCR4-NOT transcription complex subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000044">
        <property type="entry name" value="Putative ccr4-not transcription complex subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034261">
        <property type="entry name" value="CNOT4_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039780">
        <property type="entry name" value="Mot2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039515">
        <property type="entry name" value="NOT4_mRING-HC-C4C4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
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        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
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        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12603">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12603:SF0">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14570">
        <property type="entry name" value="zf-RING_4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZF_RING_2"/>
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    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 26" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0488">Methylation</keyword>
    <keyword evidence="17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="33" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15 25" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="14" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="12" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="13 26" id="KW-0862">Zinc</keyword>
    <keyword evidence="11 26" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="28">
        <location>
            <begin position="14"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="29">
        <location>
            <begin position="109"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="30">
        <location>
            <begin position="190"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="26">
        <location>
            <begin position="190"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="27">
        <location>
            <begin position="254"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="27">
        <location>
            <begin position="608"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="27">
        <location>
            <begin position="717"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="27">
        <location>
            <begin position="835"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="27">
        <location>
            <begin position="274"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="27">
        <location>
            <begin position="292"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="27">
        <location>
            <begin position="339"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="27">
        <location>
            <begin position="612"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="27">
        <location>
            <begin position="726"/>
            <end position="742"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00057081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00062432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00071435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00075062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00077837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00083547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00083942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="EMBL" id="JAV51662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="EMBL" id="KAB0791482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="33">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="858" mass="97201" checksum="D1A4D2A982B962B9" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1JWA6</accession>
    <name>A0A1Y1JWA6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PPYR_06716</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the centrin family.</text>
    </comment>
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        <property type="protein sequence ID" value="JAV53599.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
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        <property type="protein sequence ID" value="KAB0798836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="interactions" value="56"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1JWA6"/>
    <dbReference type="OrthoDB" id="343296at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Centrin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Centrin-1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="CALM/Myosin/TropC-like"/>
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        <property type="entry name" value="EF-hand-dom_pair"/>
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        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
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        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF59">
        <property type="entry name" value="EF-HAND SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="31"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="67"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="104"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="140"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="JAV53599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0798836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="175" mass="19753" checksum="8DB88B3A9F57D323" modified="2017-08-30" version="1">MAASQGATKKTSATGLNRNKKTGPKFELSDEQKTDIREAFDLFDTEGAGKIDTKELKVAIRALGFEPKKEEIKKMIADIDPDGTGKLSFEEFLQLMSVKMAEKDSKEEILKAFRLFDDDDTGKISFKNLKRVAKELGENLTDEELQEMIDEADRDGDGEISQDEFLRIMKKTSLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1JY24</accession>
    <name>A0A1Y1JY24_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PPYR_00634</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01099884">
        <property type="protein sequence ID" value="JAV53128.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1JY24"/>
    <dbReference type="InParanoid" id="A0A1Y1JY24"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026521">
        <property type="entry name" value="THAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47696">
        <property type="entry name" value="THAP DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47696:SF1">
        <property type="entry name" value="THAP DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00692">
        <property type="entry name" value="DM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="JAV53128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0803664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="189" mass="22272" checksum="DC4F87306E452011" modified="2017-08-30" version="1">MYSFPKDVQIRKAWIEFVNKEGWVPIGISYLCSQHFGEQQFDRTSMLKVRLQPNAVPTVEVTRLKYERSLNSIHTVVKVEKENAVLVTPGPSREEKFPTSVLATPVCSQQLQEDTPRNRALKRKISELQRREVLKNQKVRKLQKIIWRQKRRISVLSTMLAEFKKKTIILEEHETVEDIIQRLFQKTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1K1X7</accession>
    <name>A0A1Y1K1X7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transmembrane protein 242</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PPYR_01664</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Scaffold protein that participates in the c-ring assembly of mitochondrial ATP synthase (F(1)F(0) ATP synthase or complex V) by facilitating the membrane insertion and oligomer formation of the subunit c/ATP5MC3. Participates in the incorporation of the c-ring into vestigial complexes. Additionally influences the incorporation of subunits MT-ATP6, MT-ATP8, ATP5MJ, and ATP5MK in the ATP synthase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM242 family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01095184">
        <property type="protein sequence ID" value="JAV55472.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1K1X7"/>
    <dbReference type="FunCoup" id="A0A1Y1K1X7">
        <property type="interactions" value="403"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1K1X7"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009792">
        <property type="entry name" value="TMEM242"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13141">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13141:SF4">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07096">
        <property type="entry name" value="DUF1358"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="24"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="JAV55472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAB0804694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="150" mass="16093" checksum="C75536BF9D16904A" modified="2017-08-30" version="1">MSQEDTKNSTTHSNEGDRNFKVKAGIFLVGVTGVSALVGFGATLASVRKQDTKHFSKGMAGGLEMSEPAVSLALRALGWGTFYAFTGCGILCYSIWKLSGAESLHDFRNKMGAILPRIPKNNPPQGRTEFTGMNDLLEYLANSKSNDGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1KLN4</accession>
    <name>A0A1Y1KLN4_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_03723</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01081851">
        <property type="protein sequence ID" value="JAV61508.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01081850">
        <property type="protein sequence ID" value="JAV61509.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1KLN4"/>
    <dbReference type="InParanoid" id="A0A1Y1KLN4"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.20">
        <property type="entry name" value="Pheromone/general odorant binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006170">
        <property type="entry name" value="PBP/GOBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036728">
        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01395">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011907277" evidence="1">
        <location>
            <begin position="19"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="JAV61508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0791923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="134" mass="15052" checksum="2037384B4AA7783D" modified="2017-08-30" version="1">MNTHTLFVAILLVGAVQSRRVTQETYDIFFQLIEPYYPNCLVEAGITPGYAKDVVITAFVPDEANVKQYFDCLYVAMDLFLENGEFSREKVIGLASYMTEALVDECMPLTEREVLRVDKSLALANCLINALAID</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1KQ57</accession>
    <name>A0A1Y1KQ57_PHOPY</name>
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            <fullName evidence="4">Small ribosomal subunit protein uS10</fullName>
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            <fullName evidence="5">40S ribosomal protein S20</fullName>
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    </protein>
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        <name evidence="8" type="ORF">PPYR_00381</name>
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        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS10 family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01081625">
        <property type="protein sequence ID" value="JAV61576.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1KQ57"/>
    <dbReference type="FunCoup" id="A0A1Y1KQ57">
        <property type="interactions" value="944"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1KQ57"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.600:FF:000002">
        <property type="entry name" value="40S ribosomal protein S20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.600">
        <property type="entry name" value="Ribosomal protein S10 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00508">
        <property type="entry name" value="Ribosomal_uS10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001848">
        <property type="entry name" value="Ribosomal_uS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027486">
        <property type="entry name" value="Ribosomal_uS10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036838">
        <property type="entry name" value="Ribosomal_uS10_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005729">
        <property type="entry name" value="Ribosomal_uS10_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01046">
        <property type="entry name" value="uS10_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11700">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S10 FAMILY MEMBER"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00338">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RIBOSOMALS10"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Ribosomal protein S10"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS10" evidence="6">
        <location>
            <begin position="22"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="JAV61576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0803411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="120" mass="13464" checksum="D1AE3008587BAB62" modified="2017-08-30" version="1">MASLKENPEKPGQEAAPIHRIRITLTSRNVRSLEKVCSDLITGAKKQKLRVKGPVRMPTKVLRITTRKTPCGEGSKTWDRFQMRIHKRVIDLHSPSEIVKQITSISIEPGVEVEVTIADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1KSJ3</accession>
    <name>A0A1Y1KSJ3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Proteasome assembly chaperone 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_03345</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PSMG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01074992">
        <property type="protein sequence ID" value="JAV64353.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1KSJ3"/>
    <dbReference type="FunCoup" id="A0A1Y1KSJ3">
        <property type="interactions" value="82"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1KSJ3"/>
    <dbReference type="OrthoDB" id="17536at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080129">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016565">
        <property type="entry name" value="Proteasome_assmbl_chp_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15069">
        <property type="entry name" value="PROTEASOME ASSEMBLY CHAPERONE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15069:SF1">
        <property type="entry name" value="PROTEASOME ASSEMBLY CHAPERONE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="JAV64353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0791545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="219" mass="24310" checksum="EE1A7950A2776DBD" modified="2017-08-30" version="1">MVFGEIVEPSTRALCTDEFSENEILELSWNATPTIASAINKVFVIETAPLLSFFKMCILGDQEPICKLNETNVKVYELHDNDYIITCENSKATAGHITEKVAPWLKQASEVVVLTSGLVSLLENSDKRSSCIIKQLAYNTERVHPNLDVPNLVTGISASVFSYCVHTNTSCSLFKIFFDELPLDSINTMPLLDLIETVGLNVLKTYKLEATASHSNLYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1KUN4</accession>
    <name>A0A1Y1KUN4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytosolic fatty-acid binding proteins domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_04589</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01075067">
        <property type="protein sequence ID" value="JAV64308.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
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        <property type="protein sequence ID" value="KAB0802403.1"/>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Lipocalins"/>
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    <proteinExistence type="inferred from homology"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00008390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="JAV64308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0802403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="129" mass="14559" checksum="47F7CB5EBF73DEFC" modified="2017-08-30" version="1">MVQIVGHYKLDRNENFVEYLEALGSPEDMIKKVTVPDATTEIVQDGKTYTIKSSSQVDVTLVLDEEVDEVLPTGVPIKNLATRDGNKIVVNSSAPDNRKRQRVYEFCDQGYMVTLMVGDLVAKRYFTRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1L4M8</accession>
    <name>A0A1Y1L4M8_PHOPY</name>
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            <fullName evidence="5">Cytoplasmic phosphatidylinositol transfer protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Retinal degeneration B homolog beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_12559</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the PtdIns transfer protein family. PI transfer class IIB subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01064783">
        <property type="protein sequence ID" value="JAV68642.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KAB0792939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008526">
        <property type="term" value="F:phosphatidylinositol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.530.20:FF:000011">
        <property type="entry name" value="cytoplasmic phosphatidylinositol transfer protein 1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10658:SF54">
        <property type="entry name" value="CYTOPLASMIC PHOSPHATIDYLINOSITOL TRANSFER PROTEIN 1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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        <location>
            <begin position="3"/>
            <end position="244"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00061154"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00068698"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00082927"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF02121"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="JAV68642.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAB0792939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="303" mass="34936" checksum="3FAE354145C846F5" modified="2017-08-30" version="1">MVLTKEYRICMPITVEEYQIGQLYMIARHSLEQSGNGEGIEVVENSECVDPKHGKGRFTEKRIHLSSRLPYWIQAMIPKIFYVTEKAWNYYPFTITEYTCSFLPRFNISIQTTYENNNGCTDNSLNLTPEELAERSVERLDIAYDEVTPKHYKEEEDLRFFQSKKTHRGPLVEGWQDSYTPIMCSYKIVRASFEVWGLQTRVEDFVQSCVREVLLLGHRQAFAWIDDWIEMSHEDVRQYEGKLQVQTNQLVQQSAPSALQVSLQTAACGDFDAISDGCSIGSTPSITPNSPKSPAKKGYFSWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1L9R1</accession>
    <name>A0A1Y1L9R1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ZP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_08691</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
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        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01062630">
        <property type="protein sequence ID" value="JAV69571.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1L9R1"/>
    <dbReference type="InParanoid" id="A0A1Y1L9R1"/>
    <dbReference type="OrthoDB" id="6368363at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="JAV69571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0797698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="362" mass="39994" checksum="FD3A745E1643A0E0" modified="2017-08-30" version="1">MLRFLLCVGIVCAQDVTVKNLMGESDYRKIRLHWESDSQNVPQNGFHVRFCELQTWGFQRCRNQKVSQPEDNSITNENGFTSYDVDILGLRMATTYSFEVRTQKENSSREDRAHGDTNQNILVVPTKGFSARATQCLPHASIIEVSTGPYFGGRIAVEAADGERCALDGEPSSPRDTYTLKIDHEKCGSQVNETTVGTFVLVQENLPILTHSTRRFLVLCSFQPETLTVRAGISLPSNAVGRGQSDPIGFEEGDSYARRSRHLRPARLLQDPESDKKEDIKQEIRSTAKSIPIALLAVLMTLGIVGLVAAAVRCGSKRISREMDNVSIASSDSSTSSCSTHAEIELESNNSTISKVKEVHLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LC72</accession>
    <name>A0A1Y1LC72_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MTOR-associated protein MEAK7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">TBC/LysM-associated domain-containing protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">TLD domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PPYR_00133</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
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                <person name="Sander Lower S.E."/>
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        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
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                <person name="Sander Lower S.E."/>
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        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0794846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1LLC4"/>
    <dbReference type="InParanoid" id="A0A1Y1LLC4"/>
    <dbReference type="OrthoDB" id="671595at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.39.10">
        <property type="entry name" value="Alpha-1-antitrypsin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.497.10">
        <property type="entry name" value="Antithrombin, subunit I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023795">
        <property type="entry name" value="Serpin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023796">
        <property type="entry name" value="Serpin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000215">
        <property type="entry name" value="Serpin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036186">
        <property type="entry name" value="Serpin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042178">
        <property type="entry name" value="Serpin_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042185">
        <property type="entry name" value="Serpin_sf_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461:SF211">
        <property type="entry name" value="GH10112P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR, SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00079">
        <property type="entry name" value="Serpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00093">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56574">
        <property type="entry name" value="Serpins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00284">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033289647" description="Serpin domain-containing protein" evidence="5">
        <location>
            <begin position="16"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="Serpin" evidence="6">
        <location>
            <begin position="29"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="JAV71797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0794846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="385" mass="43284" checksum="76629494DC6567D9" modified="2017-08-30" version="1">MKLQILLLGITSVYCLDSSFRDANRQFTTKLYKELVEQKQEKLLVSPMAIQIIFSLLRAGSGGLTSEELSDALSLPRDDKAQDDMVKGVLEAYKTVQGDHYQLTLANKIYVQEDVELKASYKSKAVDVFGADVENVDFKKKENAMAVINKWVDCKTKHTIPEIVTKDDLNDALRLILLNTVYFQAPWRQRFHEPSQKPFFVDSSNTVNVDMMSDRDLYEYHESDELKAKFLKIPYRVNGMSMVMALPNEKDGLGELEKRLGDILALPKFSYNVVIVSFPKFQFDATIKLKPILNAMGIKDAFTSSANFSGISESASLSVSDAIQKNHIEVNEKGTIASSATAVLLFEYSGLVEVEPPKEFKADHPFIFFIESEAGILFIGKFTGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1MC27</accession>
    <name>A0A1Y1MC27_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">aralkylamine N-acetyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.87</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PPYR_07352</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">1611_PpyrPB1</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">1611_PpyrPB1</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>dopamine + (9Z)-octadecenoyl-CoA = N-(9Z-octadecanoyl)-dopamine + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51380"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:31883"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:59905"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:51381"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>dopamine + acetyl-CoA = N-acetyldopamine + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51388"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:59905"/>
            <dbReference type="ChEBI" id="CHEBI:125678"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:51389"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>dopamine + hexadecanoyl-CoA = N-hexadecanoyl-dopamine + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51376"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:59905"/>
            <dbReference type="ChEBI" id="CHEBI:134058"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:51377"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>serotonin + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = N-[(5Z,8Z,11Z,14Z)-eicosatetraenoyl]-serotonin + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51396"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57368"/>
            <dbReference type="ChEBI" id="CHEBI:132255"/>
            <dbReference type="ChEBI" id="CHEBI:350546"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:51397"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>serotonin + (9Z)-octadecenoyl-CoA = N-(9Z-octadecenoyl)-serotonin + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51392"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:134064"/>
            <dbReference type="ChEBI" id="CHEBI:350546"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:51393"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>serotonin + acetyl-CoA = N-acetylserotonin + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25217"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17697"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:350546"/>
            <dbReference type="EC" id="2.3.1.87"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:25218"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>serotonin + hexadecanoyl-CoA = N-hexadecanoyl-serotonin + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51384"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:134059"/>
            <dbReference type="ChEBI" id="CHEBI:350546"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:51385"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>serotonin + octadecanoyl-CoA = N-octadecanoyl-serotonin + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51400"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57394"/>
            <dbReference type="ChEBI" id="CHEBI:134065"/>
            <dbReference type="ChEBI" id="CHEBI:350546"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:51401"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Aromatic compound metabolism; melatonin biosynthesis; melatonin from serotonin: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the acetyltransferase family. AANAT subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.87" evidence="5"/>
    <dbReference type="EMBL" id="GEZM01037143">
        <property type="protein sequence ID" value="JAV82139.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01037142">
        <property type="protein sequence ID" value="JAV82140.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01037141">
        <property type="protein sequence ID" value="JAV82141.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1MC27"/>
    <dbReference type="InParanoid" id="A0A1Y1MC27"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004059">
        <property type="term" value="F:aralkylamine N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000046">
        <property type="entry name" value="Dopamine N-acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20905:SF1">
        <property type="entry name" value="AT07410P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20905">
        <property type="entry name" value="N-ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00050189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00050849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00052178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00052491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="JAV82140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAB0799472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="211" mass="24190" checksum="489322A5046642FE" modified="2017-08-30" version="1">MTFHIRPITTEDEDQISEHMRTIFRRDEPLSRSVGLADQLIQKSPRTQKDSSKREVSLVAVDELSNIVGLCLNEFKQRNDPESHFKSTNSDLQKIVELVDYIDKEADVFSKYPDVNGIICIHILSVVPAWRGKGIAKQLVIETRKIANALNAQLLQMDCSSYYSAQLALQLNFRCIYKKKYADYCVDGTPVFLIDQPHEEIGVYVQHTKEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1MFR6</accession>
    <name>A0A1Y1MFR6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PPYR_06895</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
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            <dbReference type="DOI" id="10.1038/srep38556"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
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        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
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                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
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</entry>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
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                <person name="Bessho-Uehara M."/>
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                <person name="Debat H.J."/>
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                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
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                <person name="Shigenobu S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="JAV85609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0798703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1303" mass="145730" checksum="123E28765714CC3F" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1MJZ0</accession>
    <name>A0A1Y1MJZ0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein eS17</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">40S ribosomal protein S17</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_02678</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS17 family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01031312">
        <property type="protein sequence ID" value="JAV84940.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0805708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1MJZ0"/>
    <dbReference type="FunCoup" id="A0A1Y1MJZ0">
        <property type="interactions" value="1041"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1MJZ0"/>
    <dbReference type="OrthoDB" id="1727351at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.60.20:FF:000001">
        <property type="entry name" value="40S ribosomal protein S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.60.20">
        <property type="entry name" value="Ribosomal protein S17e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00511">
        <property type="entry name" value="Ribosomal_eS17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001210">
        <property type="entry name" value="Ribosomal_eS17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018273">
        <property type="entry name" value="Ribosomal_eS17_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036401">
        <property type="entry name" value="Ribosomal_eS17_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10732">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10732:SF0">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00833">
        <property type="entry name" value="Ribosomal_S17e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116820">
        <property type="entry name" value="Rps17e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00712">
        <property type="entry name" value="RIBOSOMAL_S17E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="JAV84940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0805708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="131" mass="15361" checksum="F65C1215C55B54BB" modified="2017-08-30" version="1">MGRVRTKTVKKASKVIIEKYYTRLTLDFHTNKRICEEIAIIPTKPLRNKIAGFVTHLMKRLRHSQVRGISIKLQEEERERRDNYVPEVSALEHDIIEVDTETKEMLKMLDFNNISGLQLTQPPTNAFNRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1MSA6</accession>
    <name>A0A1Y1MSA6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">S-formylglutathione hydrolase</fullName>
            <ecNumber evidence="3 8">3.1.2.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PPYR_08976</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Serine hydrolase involved in the detoxification of formaldehyde.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>S-formylglutathione + H2O = formate + glutathione + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14961"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:57688"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="EC" id="3.1.2.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the esterase D family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.12" evidence="3 8"/>
    <dbReference type="EMBL" id="GEZM01025721">
        <property type="protein sequence ID" value="JAV87370.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1MSA6"/>
    <dbReference type="FunCoup" id="A0A1Y1MSA6">
        <property type="interactions" value="1303"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1MSA6"/>
    <dbReference type="OrthoDB" id="420518at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018738">
        <property type="term" value="F:S-formylglutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046294">
        <property type="term" value="P:formaldehyde catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000334">
        <property type="entry name" value="S-formylglutathione hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014186">
        <property type="entry name" value="S-formylglutathione_hydrol"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02821">
        <property type="entry name" value="fghA_ester_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10061">
        <property type="entry name" value="S-FORMYLGLUTATHIONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10061:SF0">
        <property type="entry name" value="S-FORMYLGLUTATHIONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0719">Serine esterase</keyword>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR614186-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="JAV87370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0797983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="282" mass="31114" checksum="F56286069C82684A" modified="2017-08-30" version="1">MTAITKITSNKIFGGTQKVFAHDSKELGCSMRFAIFIPPQCDQGKAPVIYWLSGLECTEANCIQKSGIQRHAAEHGVIIVCPDTSPRGLNLPGEKDSWDFGEGAGFYLDATEAPWNKNYRMYSYVTSELIDVVNANFPVIPGKQSIMGHSMGGHGALVCALKNPTLYKSVSAFAPICNPSQGAWGKKALEGYLGPQSKGLWSQWDATELVKSFKGDPMELFIDQGTADQFLSQLLPENLINTCKDTQMPTILKMREGYDHSYYYIATFIGEHVAYHAQHLCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1MTP2</accession>
    <name>A0A1Y1MTP2_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Presenilin</fullName>
            <ecNumber evidence="8">3.4.23.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PPYR_02227</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endoplasmic reticulum membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Golgi apparatus membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">The PAL motif is required for normal active site conformation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the peptidase A22A family.</text>
    </comment>
    <dbReference type="EC" id="3.4.23.-" evidence="8"/>
    <dbReference type="EMBL" id="GEZM01021500">
        <property type="protein sequence ID" value="JAV88971.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0805257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A1Y1MTP2"/>
    <dbReference type="FunCoup" id="A0A1Y1MTP2">
        <property type="interactions" value="1168"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1MTP2"/>
    <dbReference type="OrthoDB" id="20287at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:aspartic endopeptidase activity, intramembrane cleaving"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0034205">
        <property type="term" value="P:amyloid-beta formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:calcium ion homeostasis"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0006509">
        <property type="term" value="P:membrane protein ectodomain proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Presenilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.100">
        <property type="entry name" value="Presenilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001108">
        <property type="entry name" value="Peptidase_A22A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006639">
        <property type="entry name" value="Preselin/SPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042524">
        <property type="entry name" value="Presenilin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10202">
        <property type="entry name" value="PRESENILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10202:SF13">
        <property type="entry name" value="PRESENILIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01080">
        <property type="entry name" value="Presenilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01072">
        <property type="entry name" value="PRESENILIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00730">
        <property type="entry name" value="PSN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0914">Notch signaling pathway</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="235"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <begin position="405"/>
            <end position="424"/>
        </location>
    </feature>
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        <location>
            <begin position="430"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022976"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="JAV88971.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAB0805257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="466" mass="51705" checksum="F3402A5EED1F7458" modified="2017-08-30" version="1">MSESDTDFELSTESTRLMDGHVATSGGGGDCNGTVDNSRKRKSKQPYTDGEGYNVNAAVPDVQIAGHSAHQNEGGASQANREWRDDEEELKYGAKHVIKLFAPVSLCMLVVVATISNVNFYSVKDVFLVYTPFHEKSPDVSTKVWNAVANSLILMAVIVVMTILLIVLYKYRCYKIIHGWLIVSSLMLLSIFSYLYLEEVLRAYDIPMDYPTLLLLMWNFGVVGMVCIHWQGPLLLQQAYLIFVAALMALVFIKYMPEWTTWAVLAVISIWDLIAVLMPRGPLRILVETAQERNEQIFPALIYSSTYMYTYVATASDTEVDAPSSMQTATNSTETDNGFTEEWVQTHASRADSRQVDVPQAANTSTVQTVATAVEEERGVKLGLGDFIFYSVLVGKASSYGDWNTTLACFVAILIGLCLTLLLLAIFKKALPALPISITFGLIFYFATKEIVSPFADVLAIEQVFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1MWH1</accession>
    <name>A0A1Y1MWH1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein sleepless</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_12526</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01021934">
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        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1MWH1"/>
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    <dbReference type="OrthoDB" id="75169at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036029940" description="Protein sleepless" evidence="1">
        <location>
            <begin position="25"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="JAV88815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0792906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="136" mass="14730" checksum="CF0948054505700C" modified="2017-08-30" version="1">MASCISRYMCKALILLACIQIGSTSLRCYTCKSSFNGDCDDVRGRTLPDEGCENSKLVKAFPQAGTTYVCVVHRMAQSDDPNLSVVRGCAPDHYCDLFPNSNECVTCTTSYCNSSAKIMPSIIVSIIGFVCAKLCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1N378</accession>
    <name>A0A1Y1N378_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">1-acyl-sn-glycerol-3-phosphate acyltransferase</fullName>
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    </protein>
    <gene>
        <name evidence="10" type="ORF">PPYR_04700</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
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        <lineage>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphate + CoA</text>
            <dbReference type="Rhea" id="RHEA:19709"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57970"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.3.1.51"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 2/3.</text>
    </comment>
    <comment type="domain">
        <text evidence="5">The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.51" evidence="5"/>
    <dbReference type="EMBL" id="GEZM01018864">
        <property type="protein sequence ID" value="JAV90004.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01018862">
        <property type="protein sequence ID" value="JAV90007.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1N378"/>
    <dbReference type="FunCoup" id="A0A1Y1N378">
        <property type="interactions" value="1048"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1N378"/>
    <dbReference type="OrthoDB" id="202234at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003841">
        <property type="term" value="F:1-acylglycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07989">
        <property type="entry name" value="LPLAT_AGPAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004552">
        <property type="entry name" value="AGP_acyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00530">
        <property type="entry name" value="AGP_acyltrn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10434">
        <property type="entry name" value="1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10434:SF11">
        <property type="entry name" value="1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011907522" description="1-acyl-sn-glycerol-3-phosphate acyltransferase" evidence="7">
        <location>
            <begin position="27"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="8">
        <location>
            <begin position="93"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="JAV90007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0802514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="277" mass="31335" checksum="29E75B29E7CD84CC" modified="2017-08-30" version="1">MNSSYLEILLAACVLLLPFLYESSQACRYYLRFTIYYVWVMFFSVCLIPIMALKPGDVRNFLYAAFCCKHISSVLGLKWILRGKEHLEVERACIIVSNHQSSIDVLGLFDIWQIMDKCTVVAKKELLYAGPFGIAAWLCGLIFIDRVHSHSARNSVNEAAEIVKRKKTKLWIFPEGTRRNTSEIHSFKKGAFHMAISAQIPILPVVITNYYFLDSKQKRFDCGNVIMTTLPPISTEGMGVGDIDKLLETTRNAMIPVFHETNKEVMESFGISSASVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1N8C9</accession>
    <name>A0A1Y1N8C9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Probable methylthioribulose-1-phosphate dehydratase</fullName>
            <shortName evidence="9">MTRu-1-P dehydratase</shortName>
            <ecNumber evidence="9">4.2.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PPYR_07435</name>
        <name evidence="12" type="ORF">PPYR_13672</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>5-(methylsulfanyl)-D-ribulose 1-phosphate = 5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:15549"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58548"/>
            <dbReference type="ChEBI" id="CHEBI:58828"/>
            <dbReference type="EC" id="4.2.1.109"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 2/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldolase class II family. Adducin subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the aldolase class II family. MtnB subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.109" evidence="9"/>
    <dbReference type="EMBL" id="GEZM01010633">
        <property type="protein sequence ID" value="JAV93969.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0794052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1N8C9"/>
    <dbReference type="FunCoup" id="A0A1Y1N8C9">
        <property type="interactions" value="912"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1N8C9"/>
    <dbReference type="OrthoDB" id="191080at2759"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046570">
        <property type="term" value="F:methylthioribulose 1-phosphate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.225.10:FF:000003">
        <property type="entry name" value="Methylthioribulose-1-phosphate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="entry name" value="Class II aldolase/adducin N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03116">
        <property type="entry name" value="Salvage_MtnB_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017714">
        <property type="entry name" value="MethylthioRu-1-P_deHdtase_MtnB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027514">
        <property type="entry name" value="Salvage_MtnB_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03328">
        <property type="entry name" value="salvage_mtnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10640">
        <property type="entry name" value="METHYLTHIORIBULOSE-1-PHOSPHATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10640:SF7">
        <property type="entry name" value="METHYLTHIORIBULOSE-1-PHOSPHATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="AraD/HMP-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Class II aldolase/adducin N-terminal" evidence="10">
        <location>
            <begin position="14"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
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        <source>
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    <sequence length="238" mass="27374" checksum="41037719513718D8" modified="2017-08-30" version="1">MSVQNLADNEHPKHLIPELCRQFYHLGWVTGTGGGISIKHGEKIYIAPSGVQKERLQPIDMFVQDINGKDLELPPPEKKLKKSQCTPLFMCAYTQRNAGAVIHTHSKNALLVTMLFPGKEFKCTHLEMIKGIKNAKLGRNYRYDEELVVPIIENTPFEEDLKDRMAEVIAEYPETCAVLVRRHGIYVWGDTWQQAKTMTECYDYLMDVVIHMKQLGLNANLKPEEYELLYQKTNSLKH</sequence>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
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                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
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        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
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                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
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        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
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        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
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                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
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            <strain evidence="7">1611_PpyrPB1</strain>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
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            <dbReference type="DOI" id="10.1038/srep38556"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
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    <reference evidence="3" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01007170">
        <property type="protein sequence ID" value="JAV95321.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1NBN6"/>
    <dbReference type="InParanoid" id="A0A1Y1NBN6"/>
    <dbReference type="OrthoDB" id="8186948at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="162"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="JAV95321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0791119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0803540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="287" mass="32571" checksum="4671C0F7758DF79B" modified="2017-08-30" version="1">MLGTSISFPHCSEELPAHYMQVQKRQSSAELRSVNTAMATCYPSYELSTPTSRTVQVPVQKDYSRPLHVDCSVEYELPNQAKPPQGVRNEPLLMIHPCYFRKIESQRRSPFVNNLPQATRQPSATKRRAVRTQQQQIPQQAAQYPIQYATAVTAATERHHQQQQQQQPPQQQQQQHILHHHHHQQQLWEPMPPLVPISAAAAVQQSYCKREAAAAAMVSGCATYSSGSGDSGHWTDPDRSPDRPEDKHILSGKYRQYLRAHRLHPYVSSAIPIASTFPQIQQVCYNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1NCF4</accession>
    <name>A0A1Y1NCF4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Ras-like GTP-binding protein RhoL</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PPYR_08867</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01006866">
        <property type="protein sequence ID" value="JAV95611.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01006865">
        <property type="protein sequence ID" value="JAV95612.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01006864">
        <property type="protein sequence ID" value="JAV95613.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01006863">
        <property type="protein sequence ID" value="JAV95614.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01006862">
        <property type="protein sequence ID" value="JAV95615.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1NCF4"/>
    <dbReference type="FunCoup" id="A0A1Y1NCF4">
        <property type="interactions" value="148"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1NCF4"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001667">
        <property type="term" value="P:ameboidal-type cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022412">
        <property type="term" value="P:cellular process involved in reproduction in multicellular organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003006">
        <property type="term" value="P:developmental process involved in reproduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035099">
        <property type="term" value="P:hemocyte migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035006">
        <property type="term" value="P:melanization defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00157">
        <property type="entry name" value="Rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000983">
        <property type="entry name" value="Rho family GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="JAV95612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0797874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="186" mass="21490" checksum="24D8DF8131E75550" modified="2017-08-30" version="1">MGSQIKHVKITVVGDGMVGKTCLLISYKDNQFPEEYVPTVFENYAEVIKVDDQEYNVALWDTAGQEDYERLRPLSYPNTTCFLICYSVTGRASYENVAAKWAPEIRHHMPHTPIILVGTKIDLRQDPTKEIVTEKEGRKLKRKIKAESYIECSAKYRTNLDQVFEEAVRCSVKKKEWNHTRPCTIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1NET1</accession>
    <name>A0A1Y1NET1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="6">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_13299</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="GEZM01007534">
        <property type="protein sequence ID" value="JAV95105.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1NET1"/>
    <dbReference type="InParanoid" id="A0A1Y1NET1"/>
    <dbReference type="OrthoDB" id="6846267at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00312">
        <property type="entry name" value="Esterase_lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142:SF1">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033827525" description="Carboxylic ester hydrolase" evidence="6">
        <location>
            <begin position="20"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="7">
        <location>
            <begin position="25"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="JAV95105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0793679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="563" mass="63604" checksum="C81AA2D3941A7CB7" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1NGH6</accession>
    <name>A0A1Y1NGH6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase</fullName>
            <ecNumber evidence="5">4.1.1.97</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Parahox neighbor</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5-) decarboxylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PPYR_07619</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the stereoselective decarboxylation of 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU) to (S)-allantoin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H(+) = (S)-allantoin + CO2</text>
            <dbReference type="Rhea" id="RHEA:26301"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15678"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58639"/>
            <dbReference type="EC" id="4.1.1.97"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Purine metabolism; urate degradation; (S)-allantoin from urate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the OHCU decarboxylase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.97" evidence="5"/>
    <dbReference type="EMBL" id="GEZM01003647">
        <property type="protein sequence ID" value="JAV96658.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1NGH6"/>
    <dbReference type="InParanoid" id="A0A1Y1NGH6"/>
    <dbReference type="OrthoDB" id="9970124at2759"/>
    <dbReference type="UniPathway" id="UPA00394">
        <property type="reaction ID" value="UER00652"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051997">
        <property type="term" value="F:2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000255">
        <property type="term" value="P:allantoin metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019628">
        <property type="term" value="P:urate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3330.10">
        <property type="entry name" value="Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018020">
        <property type="entry name" value="OHCU_decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017580">
        <property type="entry name" value="OHCU_decarboxylase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036778">
        <property type="entry name" value="OHCU_decarboxylase_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03164">
        <property type="entry name" value="UHCUDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43466">
        <property type="entry name" value="2-OXO-4-HYDROXY-4-CARBOXY-5-UREIDOIMIDAZOLINE DECARBOXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43466:SF1">
        <property type="entry name" value="2-OXO-4-HYDROXY-4-CARBOXY-5-UREIDOIMIDAZOLINE DECARBOXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09349">
        <property type="entry name" value="OHCU_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158694">
        <property type="entry name" value="UraD-Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase" evidence="11">
        <location>
            <begin position="12"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00002506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF09349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="JAV96658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAB0799739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="174" mass="19698" checksum="DFB5151488B80751" modified="2017-08-30" version="1">MDPVFMNIDEVNRLPSEQFIKIFGNIVEHYPAAAIGILKNRPFRDVGSISHAANNYLDSLNENEVIRILQQHPDLAGKLADLEKMSPESTYEQTSAGLLAITSDTKQKLSCMNEQYSVKFGFPYIICVREKNSPGEILDDIESRLKNGREDELSSALEEVKKICRLRILTLIKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1NIF3</accession>
    <name>A0A1Y1NIF3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_13388</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01003645">
        <property type="protein sequence ID" value="JAV96660.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1NIF3"/>
    <dbReference type="FunCoup" id="A0A1Y1NIF3">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1NIF3"/>
    <dbReference type="OrthoDB" id="6349206at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019991">
        <property type="term" value="P:septate junction assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038976">
        <property type="entry name" value="Ssk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36692:SF2">
        <property type="entry name" value="GEO12064P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36692">
        <property type="entry name" value="PROTEIN SNAKESKIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="JAV96660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0793768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="126" mass="13720" checksum="AB87CC990DB4C72F" modified="2017-08-30" version="1">MAISRLSIIKFLELAIAVTCVGLHYHSYTGKIETDFVSSGAFCGYVIILCGVFAGHLMSSPINRRIEIFFCLVGCALFVAAGALNIQYFDNMRKGETRNYGLAKASLAIIGGAMFLIDALLTWRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1NIR8</accession>
    <name>A0A1Y1NIR8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Crossover junction endonuclease MUS81</fullName>
            <ecNumber evidence="13">3.1.22.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PPYR_10303</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">1611_PpyrPB1</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">1611_PpyrPB1</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="13">Interacts with EME1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the XPF family.</text>
    </comment>
    <dbReference type="EC" id="3.1.22.-" evidence="13"/>
    <dbReference type="EMBL" id="GEZM01003814">
        <property type="protein sequence ID" value="JAV96545.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1NIR8"/>
    <dbReference type="FunCoup" id="A0A1Y1NIR8">
        <property type="interactions" value="530"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1NIR8"/>
    <dbReference type="OrthoDB" id="5963188at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048476">
        <property type="term" value="C:Holliday junction resolvase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048257">
        <property type="term" value="F:3'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21036">
        <property type="entry name" value="WH_MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20074">
        <property type="entry name" value="XPF_nuclease_Mus81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000307">
        <property type="entry name" value="Crossover junction endonuclease MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10130:FF:000003">
        <property type="entry name" value="Crossover junction endonuclease MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.110:FF:000001">
        <property type="entry name" value="Putative Crossover junction endonuclease MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.670">
        <property type="entry name" value="Crossover junction endonuclease EME1, DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.110">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027421">
        <property type="entry name" value="DNA_pol_lamdba_lyase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042530">
        <property type="entry name" value="EME1/EME2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006166">
        <property type="entry name" value="ERCC4_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010996">
        <property type="entry name" value="HHH_MUS81"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033309">
        <property type="entry name" value="Mus81"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047417">
        <property type="entry name" value="WHD_MUS81"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047416">
        <property type="entry name" value="XPF_nuclease_Mus81"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13451">
        <property type="entry name" value="CLASS II CROSSOVER JUNCTION ENDONUCLEASE MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13451:SF0">
        <property type="entry name" value="CROSSOVER JUNCTION ENDONUCLEASE MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21292">
        <property type="entry name" value="EME1-MUS81_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02732">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14716">
        <property type="entry name" value="HHH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21136">
        <property type="entry name" value="WHD_MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00891">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47802">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10 13" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11 13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 13" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 13" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERCC4" evidence="15">
        <location>
            <begin position="274"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU369042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="JAV96545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAB0796242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="545" mass="61172" checksum="F281934041FD8F8E" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N3ZY65</accession>
    <name>A0A5N3ZY65_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_15711</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="EMBL" id="VVIM01002106">
        <property type="protein sequence ID" value="KAB0789998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N3ZY65"/>
    <dbReference type="InParanoid" id="A0A5N3ZY65"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.70:FF:000003">
        <property type="entry name" value="Protein CBG25708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000063">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF7">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="132"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0789998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="453" mass="53507" checksum="08F19BB9B26E446E" modified="2020-02-26" version="1">MSPEKFNQLVNETMKDPELITLKTVINEGWPKSKDEVKDLIKPYWDVRESLVVINNAVFKGNQYVVPKSMRAEIIAKLHYSHLGIEKTRLRARELVYWPNVNKEIKDVIQNCHACLAYGRSNPQEEMITKEMAVRPWQIVAADFFYLNDNQYLLLVDEYSKYPEVVHMRNDTSSVKVVKEFKAIFSRHGIPNLLYTDGGPQFVSNNFQQFVREWGIIHKTSSPRYPKSNGFIERHVQTIKQILKKCYLDKKDAYLALLEYRNTPISNEIPSPAELLLGRKIKGCLPVPDFQLHPQFQPNQILQTKTLNKQNYKYYYDRKSHQLPNLKIGQTVMVQNFLKKKWEPGIIKNFDKRPRSYVVEMFKQGNQLIRNRKFLKPITNENLFNNDYKFQNLFEKNIQEQLPKEKVNENVRTFSNRNLQHTDPSREAVRYDGNNTYVTKYGRSVKKPNYYKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N3ZYB4</accession>
    <name>A0A5N3ZYB4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA-directed DNA polymerase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_13733</name>
        <name evidence="1" type="ORF">PPYR_15631</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01001998">
        <property type="protein sequence ID" value="KAB0790050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0794113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N3ZYB4"/>
    <dbReference type="InParanoid" id="A0A5N3ZYB4"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511">
        <property type="entry name" value="PROTEIN CBG23764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511:SF12">
        <property type="entry name" value="RHO TERMINATION FACTOR N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0790050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0794113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="219" mass="26019" checksum="A8408B4B89FF0AE2" modified="2020-02-26" version="1" fragment="single">MPYDYFDSFDRFDELCLPPQDAFYNKLEDKPCPRRMYRRAQEVWSRFNCSNLGQYVDLYMKTDILLLADVFEQFRSSCISTYDLDPAHYFTLPGFTWDAMLKYTRQELELLTDQDMFLFVERGIRGGLSQVCSKRRAHANNKYMSKYDSTKPDVYLMYNDINNQYGWSMSQYLPYGGFEWVDSNIDITTIPDDADEGYILEVDLEYPQHLHDAHTDLPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N3ZYG8</accession>
    <name>A0A5N3ZYG8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_15578</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01001918">
        <property type="protein sequence ID" value="KAB0790101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N3ZYG8"/>
    <dbReference type="InParanoid" id="A0A5N3ZYG8"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF158">
        <property type="entry name" value="GH23626P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="4">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="477"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="517"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0790101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="536" mass="58789" checksum="906CFEA89D633950" modified="2020-02-26" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N3ZZ69</accession>
    <name>A0A5N3ZZ69_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4806 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_15270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01001419">
        <property type="protein sequence ID" value="KAB0790365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N3ZZ69"/>
    <dbReference type="InParanoid" id="A0A5N3ZZ69"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032071">
        <property type="entry name" value="DUF4806"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34153:SF2">
        <property type="entry name" value="SI:CH211-262H13.3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34153">
        <property type="entry name" value="SI:CH211-262H13.3-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16064">
        <property type="entry name" value="DUF4806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4806" evidence="2">
        <location>
            <begin position="106"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0790365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="219" mass="25469" checksum="7C49646C13DC23C6" modified="2020-02-26" version="1" fragment="single">MNYPKKIGGVKKKIISSSEEEEEDSQVGVLNISEFPDLPQDIRKNDSTEVSGFEEKLFKELSFIRVHLVKIGQQLSVLELNMKSHQLQDNDKNEEKHDNFEEIIRKFPLDTELDLRNMEVYLLNNPDFKKYLINYCSRLGGLKIDQITKIMLRKLISNKLAANYSWLGAKKKQSFNLLIAEVILCAVKQNKLIGETTEKEMIDSVKNWLKHAHVRYTNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-06-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N3ZZ88</accession>
    <name>A0A5N3ZZ88_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_15321</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01001477">
        <property type="protein sequence ID" value="KAB0790338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N3ZZ88"/>
    <dbReference type="InParanoid" id="A0A5N3ZZ88"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0790338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="140" mass="16407" checksum="2B099A3A37441448" modified="2020-02-26" version="1">MNPKMSPEEIDGSNSIQQLLACNAREMLLPSKSKTVYEAAYREYRKWYWGKKINCTTEDCILAYFSELVSYKSSPLWSKYSMLRSTINLNEGVDISKFPSLIPYLKRKGDSDRDLTILKLVLPAKFWERKPLWQILRSEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N3ZZR1</accession>
    <name>A0A5N3ZZR1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Acyl-coenzyme A oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PPYR_15036</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">1611_PpyrPB1</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the acyl-CoA oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01001121">
        <property type="protein sequence ID" value="KAB0790564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N3ZZR1"/>
    <dbReference type="InParanoid" id="A0A5N3ZZR1"/>
    <dbReference type="OrthoDB" id="538336at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005504">
        <property type="term" value="F:fatty acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016402">
        <property type="term" value="F:pristanoyl-CoA oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033540">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA oxidase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000007">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000005">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055060">
        <property type="entry name" value="ACOX_C_alpha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012258">
        <property type="entry name" value="Acyl-CoA_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002655">
        <property type="entry name" value="Acyl-CoA_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909">
        <property type="entry name" value="ELECTRON TRANSPORT OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909:SF390">
        <property type="entry name" value="PEROXISOMAL ACYL-COENZYME A OXIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01756">
        <property type="entry name" value="ACOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22924">
        <property type="entry name" value="ACOX_C_alpha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000168">
        <property type="entry name" value="Acyl-CoA_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9 10" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4 9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="283"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="13">
        <location>
            <begin position="129"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase C-alpha1" evidence="14">
        <location>
            <begin position="316"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase C-terminal" evidence="12">
        <location>
            <begin position="467"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000168-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF22924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAB0790564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="647" mass="72901" checksum="E516B9B23C78A9E1" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A075</accession>
    <name>A0A5N4A075_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cGMP-dependent protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PPYR_14869</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">1611_PpyrPB1</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.12"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.12" evidence="2"/>
    <dbReference type="EMBL" id="VVIM01000899">
        <property type="protein sequence ID" value="KAB0790689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A075"/>
    <dbReference type="InParanoid" id="A0A5N4A075"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030553">
        <property type="term" value="F:cGMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004692">
        <property type="term" value="F:cGMP-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd05572">
        <property type="entry name" value="STKc_cGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000096">
        <property type="entry name" value="cGMP-dependent protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000064">
        <property type="entry name" value="cGMP-dependent protein kinase, isozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002374">
        <property type="entry name" value="cGMP_dep_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035014">
        <property type="entry name" value="STKc_cGK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353:SF111">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00104">
        <property type="entry name" value="CGMPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00888">
        <property type="entry name" value="CNMP_BINDING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0140">cGMP</keyword>
    <keyword evidence="9" id="KW-0142">cGMP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="15">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="15">
        <location>
            <begin position="76"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="214"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="16">
        <location>
            <begin position="474"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="499"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAB0790689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="525" mass="59897" checksum="48E8ADA5C3C447DC" modified="2020-02-26" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A0J8</accession>
    <name>A0A5N4A0J8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Helitron helicase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_15004</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000716">
        <property type="protein sequence ID" value="KAB0790841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A0J8"/>
    <dbReference type="InParanoid" id="A0A5N4A0J8"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786:SF74">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786">
        <property type="entry name" value="DNA BINDING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0790841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="203" mass="23890" checksum="D730F4E7BE107D2C" modified="2020-02-26" version="1" fragment="single">QIYHRAGSLLPPSDADYKFLQIYFMGNSSEELDTRCAINSSVKKSVVKQLQTFFHEHNKLVKLFKAALDRMPSDDHKIVIRADKRPTKEHPRRLNVPTIDEVAIVVVDEHFESRDIILHRRNDQLQRVYETHRSYDALQYPIIFWQGEDGCHFSIKMINPRPGAESNKNISSMNYYSYRLMVREGEDNHILKCRRLFHQYAVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A0S9</accession>
    <name>A0A5N4A0S9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PPYR_14955</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000684">
        <property type="protein sequence ID" value="KAB0790868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A0S9"/>
    <dbReference type="InParanoid" id="A0A5N4A0S9"/>
    <dbReference type="OrthoDB" id="427030at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012934">
        <property type="entry name" value="Znf_AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379:SF127">
        <property type="entry name" value="BLOODY FINGERS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379">
        <property type="entry name" value="KRAB AND ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07776">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00868">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51915">
        <property type="entry name" value="ZAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZAD" evidence="9">
        <location>
            <begin position="4"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="488"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="517"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="646"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="678"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="704"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="786"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="845"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="1072"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="895"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="945"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1167"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="901"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1172"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1194"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="6"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0790868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1266" mass="144463" checksum="7F1F16036FE9E5C0" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A159</accession>
    <name>A0A5N4A159_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PPYR_02862</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">1611_PpyrPB1</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Plus-end directed microtubule motor that may be used for anterograde axonal transport and could conceivably move cargos in fly neurons different than those moved by kinesin heavy chain or other plus-end directed motors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10 11">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A159"/>
    <dbReference type="FunCoup" id="A0A5N4A159">
        <property type="interactions" value="18"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A159"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000029">
        <property type="entry name" value="Kinesin-like protein KIF17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969:SF21">
        <property type="entry name" value="KINESIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 11" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 10 11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="14">
        <location>
            <begin position="5"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="468"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="390"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="520"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="468"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="89"/>
            <end position="96"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00060187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAB0791062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="659" mass="75539" checksum="06A3181152C6E589" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A1V6</accession>
    <name>A0A5N4A1V6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">LRRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PPYR_03113</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A1V6"/>
    <dbReference type="InParanoid" id="A0A5N4A1V6"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001164">
        <property type="entry name" value="GH01279p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000770">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050328">
        <property type="entry name" value="Dev_Immune_Receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373:SF370">
        <property type="entry name" value="FISH-LIPS, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373">
        <property type="entry name" value="SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="27"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024270891" description="LRRCT domain-containing protein" evidence="5">
        <location>
            <begin position="21"/>
            <end position="815"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0791313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="815" mass="90995" checksum="E8D78B4468950090" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A1X8</accession>
    <name>A0A5N4A1X8_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_03089</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A1X8"/>
    <dbReference type="InParanoid" id="A0A5N4A1X8"/>
    <dbReference type="OrthoDB" id="8196554at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.30">
        <property type="entry name" value="Haemolymph juvenile hormone binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010562">
        <property type="entry name" value="Haemolymph_juvenile_hormone-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038606">
        <property type="entry name" value="To_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008:SF32">
        <property type="entry name" value="CIRCADIAN CLOCK-CONTROLLED PROTEIN DAYWAKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008">
        <property type="entry name" value="PROTEIN TAKEOUT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06585">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00700">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024384318" evidence="1">
        <location>
            <begin position="17"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0791289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="251" mass="28750" checksum="7004EF5DFC777341" modified="2020-02-26" version="1">MRTIVWLCCILVTCHASHRRTFLSLFKVCPRSNPHWNDCLKDAIQDALSVLKDGLYQYHFPSMNPIKVENWVVEPTPVLNFVQELENIELFNHTEVTIEKVDAIESDGEFTLKIKCTGPAVRYSADYKYVDAIIDGFDYSSEGRSDYMIVGYRADLSMAGKVGVNGLLKITKSEVNIKCDTFYGVYKSTDKELSTRINNFLDVNRIVLNPHVMKKFGDLHAYAYKVLANTIFAQIRFDEMFPSSELRRCTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A3S4</accession>
    <name>A0A5N4A3S4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cyclic nucleotide-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PPYR_03719</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A3S4"/>
    <dbReference type="FunCoup" id="A0A5N4A3S4">
        <property type="interactions" value="13"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A3S4"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005221">
        <property type="term" value="F:intracellularly cyclic nucleotide-activated monoatomic cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.630:FF:000004">
        <property type="entry name" value="Cyclic nucleotide-gated olfactory channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000126">
        <property type="entry name" value="Uncharacterized protein, isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000058">
        <property type="entry name" value="Uncharacterized protein, isoform D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.630">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050866">
        <property type="entry name" value="CNG_cation_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45638">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45638:SF7">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-GATED ION CHANNEL-LIKE, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00888">
        <property type="entry name" value="CNMP_BINDING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="302"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="403"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="11">
        <location>
            <begin position="510"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="125"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="636"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="695"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="749"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="803"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="872"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="997"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1116"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="36"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="716"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1000"/>
            <end position="1023"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAB0791919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1161" mass="130705" checksum="704002A0C5EB08E2" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A3T6</accession>
    <name>A0A5N4A3T6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CHK kinase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_13923</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0791962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A3T6"/>
    <dbReference type="InParanoid" id="A0A5N4A3T6"/>
    <dbReference type="OrthoDB" id="8250698at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015897">
        <property type="entry name" value="CHK_kinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004119">
        <property type="entry name" value="EcKL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012:SF56">
        <property type="entry name" value="CHK KINASE-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012">
        <property type="entry name" value="PROTEIN KINASE-LIKE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02958">
        <property type="entry name" value="EcKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00587">
        <property type="entry name" value="CHK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHK kinase-like" evidence="1">
        <location>
            <begin position="130"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0791962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="400" mass="45306" checksum="99EF4B7F60255222" modified="2020-02-26" version="1">MKTLKMSVVPKLITKDFLQAALCAYRKEDVRVLDFSLSDGISGAKYFCSNMSSIAITYCTSRSERECKMKVIAKCLPDDEKMLQLLTNANAFPCEMSVYSRILPAMYDLDFREKVAPVAIRVESKETPILLLEDVTALGYRMAKCEGGFDLEHSLLVIEKLAYFHAASVAVNEGEPGILQSYTGMYADESTFDMSLKACKPSLVEVCQKTPELVKYVNKVSNCAMLTYSAVVKPSKHLNVLNHGDAWTNNMMFRYDTQGKLADVIMVDYQYAGYGSPAVDLSYFWITSTSLEVKRKGYEFILAHYHKELSKKMSKLRLRTDTPTLEDIKDDFVSHAAYGFMTLLFILPLLAEKKGPNETFVEYLTDDQKDGYRYRCFNSAKHVETLKVLLPVFDEIGLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A6D4</accession>
    <name>A0A5N4A6D4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PPYR_12514</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">1611_PpyrPB1</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Microsome membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 15">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0792894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A6D4"/>
    <dbReference type="InParanoid" id="A0A5N4A6D4"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
        <property type="entry name" value="Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291:SF189">
        <property type="entry name" value="CYTOCHROME P450 4C3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 14 15" id="KW-0349">Heme</keyword>
    <keyword evidence="11 14 15" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0492">Microsome</keyword>
    <keyword evidence="12 15" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="10 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="14">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAB0792894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="332" mass="38273" checksum="23F4AAE4BDC886F6" modified="2020-02-26" version="1">MVPEDIQVLLSSGKYLNKGQTYQLLEPWVGKGLFNSSVSRNTILKPLETVMGTKLDEDNEEVGKYLAASHRIGELFIHQLSRPWYAFLPIYPLTPSYWESRKVLKVLHDFTHNIIQEKRKNFAIKGASPKGGAGLLDLLIENSLDERIPVADIREEADAFMFAQKVYEEVEEVFSKTDDSTFYEDLQSMRYLDQVLKETLRLYPSGPMISRYITEEMTTHTGYILPKGTNVNVRIYDIHHDPRLYPDPYKFDPERFSPENCKNRHPFAYLAFSAGPRGCMGNKFSLLMGKTIISSILREYEVMPVDTPKSITLVAHVVLKTKEPIKLKFRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A6J1</accession>
    <name>A0A5N4A6J1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4200 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_12498</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0792878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A6J1"/>
    <dbReference type="InParanoid" id="A0A5N4A6J1"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051147">
        <property type="entry name" value="CFAP_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025252">
        <property type="entry name" value="DUF4200"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21683:SF3">
        <property type="entry name" value="CILIA AND FLAGELLA ASSOCIATED PROTEIN 100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21683">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 42 LIKE-2-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13863">
        <property type="entry name" value="DUF4200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4200" evidence="3">
        <location>
            <begin position="179"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="382"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0792878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="570" mass="67699" checksum="35B252AFCA609EA2" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A6S6</accession>
    <name>A0A5N4A6S6_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_12654</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A6S6"/>
    <dbReference type="InParanoid" id="A0A5N4A6S6"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="448"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="260"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="283"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="512"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0793034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="641" mass="72320" checksum="19A4F2C8F87C9884" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A719</accession>
    <name>A0A5N4A719_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_12725</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A719"/>
    <dbReference type="InParanoid" id="A0A5N4A719"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0793105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="186" mass="20158" checksum="C94D07A543906B47" modified="2020-02-26" version="1">MIGAMPAVAVRHERKKGQDKRCKRPSQLYIGGHWVRPLSPSPTPSPNGQNLDNTDDRLPEYYVCGKVSALQIIVGCLLLGAIVLVVGLVQLTPNAADADHRYIFLGAGSILLVLGLIMTAVRCCCMHCAETRATEEEAPPPIDAINSIDVLVQRRDTQITSPSELDALIAKRAQEPDCKESSSEDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A9E1</accession>
    <name>A0A5N4A9E1_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_13566</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily. Omega family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A9E1"/>
    <dbReference type="InParanoid" id="A0A5N4A9E1"/>
    <dbReference type="OrthoDB" id="4951845at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045174">
        <property type="term" value="F:glutathione dehydrogenase (ascorbate) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000009">
        <property type="entry name" value="Glutathione S-transferase omega-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000123">
        <property type="entry name" value="Glutathione transferase o1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005442">
        <property type="entry name" value="GST_omega"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050983">
        <property type="entry name" value="GST_Omega/HSP26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968:SF6">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE OMEGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13410">
        <property type="entry name" value="GST_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13417">
        <property type="entry name" value="GST_N_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01625">
        <property type="entry name" value="GSTRNSFRASEO"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="3">
        <location>
            <begin position="18"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="4">
        <location>
            <begin position="92"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0793946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="231" mass="26929" checksum="DC7C6AD821F351E3" modified="2020-02-26" version="1">MSEKHLRKGSKFPQKENGQLRLYSTKYCPYAQRVRIVLALKDIPYETVNLHCFDKPEWMYDLNPAGLVPIFDTGTELLTESLKICNYLEKAFPKPSLPLNERDATLLAEFDALLALFYKVANNPDLGDFLQLLKHVEKYEGELSKRGKYFGGDEPRMIDFMIWPWAERAAMFDKLFPEHLPAPDALHNLRAWCARMRQHPTLLQLRTNVESQIEIYDLVRAGKHKEIDFDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A9Q1</accession>
    <name>A0A5N4A9Q1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_13657</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0794037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A9Q1"/>
    <dbReference type="InParanoid" id="A0A5N4A9Q1"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0794037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="123" mass="13541" checksum="96FAF0E67BA82D37" modified="2020-02-26" version="1">MNIGALCGCVLLALLFDILGRKPILLLGAVLVFSSWILIGVATSVGVLAFGRVVGGLGQGISIPVSNHFSSQTDYILSSALMCTYVKYRAKRSEENWGPFLWSYLYLEMYSSLPQGHIYRTQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AA44</accession>
    <name>A0A5N4AA44_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dynein regulatory complex protein 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PPYR_13815</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Flagellum axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DRC10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0794195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AA44"/>
    <dbReference type="InParanoid" id="A0A5N4AA44"/>
    <dbReference type="OrthoDB" id="536093at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042815">
        <property type="entry name" value="DRC10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31598:SF1">
        <property type="entry name" value="DYNEIN REGULATORY COMPLEX PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31598">
        <property type="entry name" value="IQ DOMAIN-CONTAINING PROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0969">Cilium</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0282">Flagellum</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="232"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0794195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="330" mass="38580" checksum="02A2432E91459AED" modified="2020-02-26" version="1">MDAVDFQVCIIRLVYIINETIEKLKIAICLPKLLDNPGRFQMRQYLETVWNNTAFKDKTLRDHAKLADPQALRLVEEMQKLRAIAADRLQKTVSEEKVHRQCLTNAWLQSARIRADIKELNDRVDEQRGAWENQLDEKNGILFSYQRIVDQLGAQLRRGVIEATRKTAEELRQKHAASSVRQSHLASDVRLALVEYQRLLSKDLRHEKALRAKRAEVQMDVVNWLVRFDADVRSAQERLEDLAAGYKEESERLEELRMLFGQQEVEYNGVLAEKEADRIRSEEEVELFLHNYSAKIIQRGWRAYRRRLIEFKKSKKGKGKGKGKQKKSPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AAD2</accession>
    <name>A0A5N4AAD2_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Long-chain-fatty-acid--CoA ligase</fullName>
            <ecNumber evidence="13">6.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PPYR_13900</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">1611_PpyrPB1</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19713"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32395"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57368"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.15"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:19714"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(E)-hexadec-2-enoate + ATP + CoA = (2E)-hexadecenoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:36139"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:61526"/>
            <dbReference type="ChEBI" id="CHEBI:72745"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:36140"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + ATP + CoA = 12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:52112"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:90718"/>
            <dbReference type="ChEBI" id="CHEBI:136408"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:52113"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + ATP + CoA = 15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:52116"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:78832"/>
            <dbReference type="ChEBI" id="CHEBI:136409"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:52117"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = 5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:52108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:65341"/>
            <dbReference type="ChEBI" id="CHEBI:136407"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:52109"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15421"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57560"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:15422"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>hexadecanoate + ATP + CoA = hexadecanoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:30751"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:30752"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 13">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.3" evidence="13"/>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0794280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AAD2"/>
    <dbReference type="FunCoup" id="A0A5N4AAD2">
        <property type="interactions" value="626"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AAD2"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047676">
        <property type="term" value="F:arachidonate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05927">
        <property type="entry name" value="LC-FACS_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045311">
        <property type="entry name" value="LC-FACS_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF107">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 13" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="14">
        <location>
            <begin position="115"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU369030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAB0794280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="692" mass="77040" checksum="6FA7056693AEC24B" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AAG9</accession>
    <name>A0A5N4AAG9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_11159</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0794320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AAG9"/>
    <dbReference type="FunCoup" id="A0A5N4AAG9">
        <property type="interactions" value="88"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AAG9"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098887">
        <property type="term" value="P:neurotransmitter receptor transport, endosome to postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06683">
        <property type="entry name" value="PDZ6_GRIP1-2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06685">
        <property type="entry name" value="PDZ7_GRIP1-2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000035">
        <property type="entry name" value="Glutamate receptor interacting protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043545">
        <property type="entry name" value="GRIP1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46227:SF2">
        <property type="entry name" value="FI03335P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46227">
        <property type="entry name" value="GLUTAMATE RECEPTOR-INTERACTING PROTEIN GRIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PDZ" evidence="4">
        <location>
            <begin position="55"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="4">
        <location>
            <begin position="156"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="4">
        <location>
            <begin position="254"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="4">
        <location>
            <begin position="472"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0794320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="593" mass="65270" checksum="C1AE5E48039910A8" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AC66</accession>
    <name>A0A5N4AC66_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Carboxypeptidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PPYR_11759</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0794920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AC66"/>
    <dbReference type="InParanoid" id="A0A5N4AC66"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000096">
        <property type="entry name" value="Carboxypeptidase vitellogenic-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033124">
        <property type="entry name" value="Ser_caboxypep_his_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF472">
        <property type="entry name" value="SERINE CARBOXYPEPTIDASE CPVL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00560">
        <property type="entry name" value="CARBOXYPEPT_SER_HIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024298341" description="Carboxypeptidase" evidence="7">
        <location>
            <begin position="22"/>
            <end position="855"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0794920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="855" mass="98927" checksum="1B593CABD60F7459" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ACU3</accession>
    <name>A0A5N4ACU3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PPYR_11973</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Trehalose transporter subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0795134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ACU3"/>
    <dbReference type="InParanoid" id="A0A5N4ACU3"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000055">
        <property type="entry name" value="Facilitated trehalose transporter Tret1-2 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050549">
        <property type="entry name" value="MFS_Trehalose_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021:SF46">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="254"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="318"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="351"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="388"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="421"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="15"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0795134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="478" mass="52017" checksum="953E3719D0688F56" modified="2020-02-26" version="1">MVVVDISKVFPGRIPQILATVTGTLTALSDGMQYGWSAPIIPLLQQPSSPVKITNSDIVWIENTFMLGGLAGIPLTIYLLDKLGRKNSMLIAAVENLIAWLLLIFASSSEVILVARFLTGFAGDCNFVATPMYIAEIADKKIRGRLGALIFIMMLMGILLIYSIGPFISIAASSSVGAAVIITQLLTFSFMPESPYYLLVKNRKEEARQALRILRGTEDVDQELEEIAQAVEEENRARGRPLELFTVKSNRKAIIIMSVLNFAQHFSGVSVILMNLHMILEDAATNIPPSIIAIIFSVLMLFASGLSALLIDSLGRKILLYTSCFLTAVTLLLLATYFACKNNDVNMEAYSWVPAVAVISYAITFKCGLGLIPIVLTAELFPTNVKALGCTVSDAMYIIGSVSSIYAFHFLHMNYGMHVPFFLFGCACLLTGIFSLLIIPETKGKTLDEIQKLLKGEESAVNGACVSDADSETIPLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AD28</accession>
    <name>A0A5N4AD28_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_11996</name>
        <name evidence="3" type="ORF">PPYR_12050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0795157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0795211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AD28"/>
    <dbReference type="InParanoid" id="A0A5N4AD28"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0795157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0795211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="106" mass="12392" checksum="1F8D1902A0F7568C" modified="2020-02-26" version="1">MIDQKHDFQPFFSEAPKKEIGIEFNFFLRCSRDKKMFNGGALQLLNWEFVGRHKVRKLSHNLRGVYGNDRSDLSEEILLLALDFIHVSAFALLLTMISFFKKILVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AD59</accession>
    <name>A0A5N4AD59_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RNA (guanine-9-)-methyltransferase domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PPYR_12093</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0795254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AD59"/>
    <dbReference type="FunCoup" id="A0A5N4AD59">
        <property type="interactions" value="1317"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AD59"/>
    <dbReference type="OrthoDB" id="9976048at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097745">
        <property type="term" value="P:mitochondrial tRNA 5'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070131">
        <property type="term" value="P:positive regulation of mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18102">
        <property type="entry name" value="Trm10_MRRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1280.30:FF:000003">
        <property type="entry name" value="tRNA methyltransferase 10C, mitochondrial RNase P subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028564">
        <property type="entry name" value="MT_TRM10-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038459">
        <property type="entry name" value="MT_TRM10-typ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025812">
        <property type="entry name" value="Trm10_C_MTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007356">
        <property type="entry name" value="tRNA_m1G_MeTrfase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13563">
        <property type="entry name" value="TRNA (GUANINE-9-) METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13563:SF5">
        <property type="entry name" value="TRNA METHYLTRANSFERASE 10 HOMOLOG C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51675">
        <property type="entry name" value="SAM_MT_TRM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="SAM-dependent MTase TRM10-type" evidence="10">
        <location>
            <begin position="180"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0795254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="426" mass="49830" checksum="6FF2C584F442EC8C" modified="2020-02-26" version="1">MFRILRCCRLGVNLIDSVIKDSSCKPLKYRQIPNFTFKIKNYTNSVTVTPSLEAENSDEPNVSEIVGDDEELAHKLRVLILEAEVFRQEGKGVPDNSSIKNEQWKYLLTLPSISARRKYLEFLYKVEKKKENRQRKKEDKRIEWEASEKPKRDREDVMNYNLGGNHFMLRIYDTTMNQMYNNRLIQAMQFGQKMVVDCGFGQNMTPRENANCAKQLMLLFAENRGSDDPFDLHYCNTVRNSSLMNGLNKFITTMYEPWFPLHLHEESYLDVFPKEQLVYLTPHCKDVLKTYSHDDIYIIGGIVDKVNNEPLSLAKAKKEGLRMAKLPLDYYLDWGSGSGKSLTINQVLSILVDVKATGDWKHALRHVPRRKLANYFEEVAPRKLFNVAQGNYPDKPKHKFNKDYKYSKDFDNLKYLSRVSNIKRYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ADC5</accession>
    <name>A0A5N4ADC5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rho GTPase-activating protein 21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PPYR_12169</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0795330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A5N4ADC5">
        <property type="interactions" value="202"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4ADC5"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.555.10:FF:000058">
        <property type="entry name" value="GTPase-activating protein pac-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041681">
        <property type="entry name" value="PH_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001605">
        <property type="entry name" value="PH_dom-spectrin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23175">
        <property type="entry name" value="PDZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23175:SF23">
        <property type="entry name" value="PDZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15410">
        <property type="entry name" value="PH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00683">
        <property type="entry name" value="SPECTRINPH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="4">
        <location>
            <begin position="56"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="847"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="5">
        <location>
            <begin position="1071"/>
            <end position="1263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="316"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="371"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="562"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="719"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="819"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="972"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1495"/>
            <end position="1531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1639"/>
            <end position="1670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1697"/>
            <end position="1722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1750"/>
            <end position="1813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="325"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="391"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="428"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="441"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="562"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="589"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="719"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="819"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="972"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1501"/>
            <end position="1520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1750"/>
            <end position="1760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1770"/>
            <end position="1804"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0795330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1925" mass="215762" checksum="44681B166649CA30" modified="2020-02-26" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AEN8</accession>
    <name>A0A5N4AEN8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PAN2-PAN3 deadenylation complex subunit PAN3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">PAB1P-dependent poly(A)-specific ribonuclease</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Poly(A)-nuclease deadenylation complex subunit 3</fullName>
            <shortName evidence="6">PAN deadenylation complex subunit 3</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">PAN3</name>
        <name evidence="8" type="ORF">PPYR_09858</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and PABP, and to miRNA targets via its interaction with GW182 family proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer. Forms a heterotrimer with a catalytic subunit PAN2 to form the poly(A)-nuclease (PAN) deadenylation complex. Interacts (via PAM-2 motif) with poly(A)-binding protein (via PABC domain), conferring substrate specificity of the enzyme complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
            <location evidence="6">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="6">Contains a pseudokinase domain. The protein kinase domain is predicted to be catalytically inactive because some of the residues important for catalytic activity are substituted and it lacks the equivalent of the binding site for a peptide substrate. However, it has retained an ATP-binding site and ATP-binding is required for mRNA degradation, stimulating the activity of the PAN2 nuclease in vitro. The nucleotide-binding site is juxtaposed to the RNase active site of PAN2 in the complex and may actually bind nucleosides of a poly(A) RNA rather than ATP, feeding the poly(A)-tail to the active site of the deadenylase and thus increasing the efficiency with which this distributive enzyme degrades oligo(A) RNAs.</text>
    </comment>
    <comment type="domain">
        <text evidence="6">The N-terminal zinc finger binds to poly(A) RNA.</text>
    </comment>
    <comment type="domain">
        <text evidence="6">The pseudokinase domain, the coiled-coil (CC), and C-terminal knob domain (CK) form a structural unit (PKC) that forms an extensive high-affinity interaction surface for PAN2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the protein kinase superfamily. PAN3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0795797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AEN8"/>
    <dbReference type="FunCoup" id="A0A5N4AEN8">
        <property type="interactions" value="1807"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AEN8"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031251">
        <property type="term" value="C:PAN complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010606">
        <property type="term" value="P:positive regulation of cytoplasmic mRNA processing body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.3700:FF:000001">
        <property type="entry name" value="PAN2-PAN3 deadenylation complex subunit PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000451">
        <property type="entry name" value="PAN2-PAN3 deadenylation complex subunit PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.5160:FF:000002">
        <property type="entry name" value="PAN2-PAN3 deadenylation complex subunit PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.5160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03181">
        <property type="entry name" value="PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030844">
        <property type="entry name" value="PAN3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041332">
        <property type="entry name" value="Pan3_CK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12272">
        <property type="entry name" value="DEADENYLATION COMPLEX SUBUNIT PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12272:SF11">
        <property type="entry name" value="PAN2-PAN3 DEADENYLATION COMPLEX SUBUNIT PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18101">
        <property type="entry name" value="Pan3_CK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="106"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Knob domain" evidence="6">
        <location>
            <begin position="412"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="373"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="184"/>
            <end position="191"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="267"/>
            <end position="268"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0795797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="512" mass="57729" checksum="66C60BC81889826D" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AEQ1</accession>
    <name>A0A5N4AEQ1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="6">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_09863</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0795802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AEQ1"/>
    <dbReference type="InParanoid" id="A0A5N4AEQ1"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024320859" description="Carboxylic ester hydrolase" evidence="7">
        <location>
            <begin position="16"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="8">
        <location>
            <begin position="21"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0795802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="549" mass="61755" checksum="71948BB707342137" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AF64</accession>
    <name>A0A5N4AF64_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PPYR_10038</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0795977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AF64"/>
    <dbReference type="InParanoid" id="A0A5N4AF64"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021896">
        <property type="entry name" value="THAP9-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048366">
        <property type="entry name" value="TNP-like_GBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048367">
        <property type="entry name" value="TNP-like_RNaseH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048365">
        <property type="entry name" value="TNP-like_RNaseH_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47577:SF2">
        <property type="entry name" value="THAP DOMAIN CONTAINING 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47577">
        <property type="entry name" value="THAP DOMAIN-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21788">
        <property type="entry name" value="TNP-like_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21789">
        <property type="entry name" value="TNP-like_RNaseH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21787">
        <property type="entry name" value="TNP-like_RNaseH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12017">
        <property type="entry name" value="Tnp_P_element"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THAP9-like helix-turn-helix" evidence="2">
        <location>
            <begin position="141"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Transposable element P transposase-like RNase H" evidence="3">
        <location>
            <begin position="228"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="Transposable element P transposase-like GTP-binding insertion" evidence="4">
        <location>
            <begin position="393"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="Transposable element P transposase-like RNase H C-terminal" evidence="5">
        <location>
            <begin position="582"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF21788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF21789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0795977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="610" mass="69804" checksum="265D1F00A16E39C6" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AFA1</accession>
    <name>A0A5N4AFA1_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_10064</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AFA1"/>
    <dbReference type="InParanoid" id="A0A5N4AFA1"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0796003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="101" mass="11121" checksum="102F1DCA37717E1A" modified="2020-02-26" version="1">MMAARDEVSSDVNGNFSQQSDVGETAASEEVRKNSIGSTNATKWPEVKLREKRLPTGQEKSAAERRRHSRNRLSNRRSTGFVSAEEMAAAATLHNENTSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AFB0</accession>
    <name>A0A5N4AFB0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_10068</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AFB0"/>
    <dbReference type="InParanoid" id="A0A5N4AFB0"/>
    <dbReference type="OrthoDB" id="409642at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18490">
        <property type="entry name" value="BACK_BTBD8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18286">
        <property type="entry name" value="BTB2_POZ_BTBD8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043225">
        <property type="entry name" value="BACK_BTBD8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22427">
        <property type="entry name" value="GH15728P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22427:SF7">
        <property type="entry name" value="GH15728P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26017">
        <property type="entry name" value="BACK_BTBD8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="354"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="676"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="174"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="687"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="700"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="733"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="778"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="812"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="848"/>
            <end position="859"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0796007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="859" mass="96077" checksum="9C8D6B8BAA76C8CA" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AGP2</accession>
    <name>A0A5N4AGP2_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_10507</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AGP2"/>
    <dbReference type="InParanoid" id="A0A5N4AGP2"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005881">
        <property type="term" value="C:cytoplasmic microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990023">
        <property type="term" value="C:mitotic spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097431">
        <property type="term" value="C:mitotic spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051256">
        <property type="term" value="P:mitotic spindle midzone assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032467">
        <property type="term" value="P:positive regulation of cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039302">
        <property type="entry name" value="MAP10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21831">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21831:SF2">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14924">
        <property type="entry name" value="MAP10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="415"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0796446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="441" mass="47591" checksum="BC8F90270313C3EA" modified="2020-02-26" version="1">MDKIVTENLFLLEFLVDNVHLDPTVIRGIGDVSGDKCVSVQFLDNPPLDICEDDFAPKRRYSQDSSNVKSGKSCLFSLTPMQANEATYQFDVHVTVFKKIQQTEDVAQKMQVGTSLISIINLFNELIASVSMPVNESGPTAKTLKDTFQILNHVGQYVGDIGMYIRMSCFGKLIVTQFQMNLDDKSVLFKDKEGHSLYRYKKAGQATAKKEDECKPSVPVCAIPSCPAREAKCPEVCANAAPVNPADCYQEIGASMGGNALRIRVHKDKKLENVDGDEDSCCCGTNTSQSKKNQPRAIGGGGCTTTEQSVAMRPGYDYDGTPNTPFSFKLGGCGMNTSNNVTVVPPISTAPDGTQYTELADPNRDVFILRIGKKSENKDKKNNLELELCTPKGPDLKPIPKKETRDTQYEDADVAGGGGGGGKGGKGGKGGKGGKGKKGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AHF5</accession>
    <name>A0A5N4AHF5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">WD repeat-containing protein 89</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_00386</name>
        <name evidence="6" type="ORF">PPYR_10802</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AHF5"/>
    <dbReference type="FunCoup" id="A0A5N4AHF5">
        <property type="interactions" value="1205"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AHF5"/>
    <dbReference type="OrthoDB" id="25131at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039328">
        <property type="entry name" value="WDR89"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22889">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 89"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22889:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 89"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="183"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="333"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00021125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0796741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0803416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="370" mass="41697" checksum="69AB1D35C6C84F8D" modified="2020-02-26" version="1">MDHKNSSELNLEDYDSDSNEDEAVSSINACPLVTEKEINRKDDSYILHLSATSDASCNILIGTSNNSCEIFRLGENRLAKLETLENFEHPIIGVQFSPESNDLMYIATSLGNIQLWDLRTPQKFVVQFTEKKEEGSSNDLKTLACFNASANNRLLTAGTELYKGEAFILFWDIRNTTLMGGYWESHTDDVTQVVFDPNDADKLMSGSVDGLINVYDVKHTNEDDALMDSFNTESSVEQLCWYSNKGKDFISCITHTADVQLWSPDDAEPYAHFRRSDITKAMKRKSEAHCYVAGAHRLLGNELLILAGSNWNDGEHLKCMSTSNKKLESFGTLKENRQRVRCSVFNQYHNLLMTGGEQGILNVWNVNLNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AII0</accession>
    <name>A0A5N4AII0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_08125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AII0"/>
    <dbReference type="InParanoid" id="A0A5N4AII0"/>
    <dbReference type="OrthoDB" id="6762350at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061343">
        <property type="term" value="P:cell adhesion involved in heart morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007508">
        <property type="term" value="P:larval heart development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33395:SF22">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33395">
        <property type="entry name" value="TRANSCRIPTASE, PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0797131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="315" mass="35775" checksum="510FCE4D3640CC1E" modified="2020-02-26" version="1">MKIVHVNVRSLISKFSNFKDMVIKGKFDVVMVSETWLNCDISDDLINIVGYTVLRKDRCSRGGGVAIYVKQPLNNVVLNTPSSIEQLWVGIEINRKKVTMGCLYRPPHCDPNFFVDELEETLTNLIMIHDYVLAMGDLNFNLLLHNNSSVEYFTMSLQNIGFYQLVDSPTRITSTTSSLLDLLITNDCGLVSACDVVSVSDLADHDLVVATLELDDHVVPNLPVLYRAYKQLDMHAFDQELHCLPFLDMLGLEGVNLKLEYFNSLLSYLLNKHLPLKSKVFKKTPSLWLSENTKLLIKLRDNALRKSRQTGKPQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AIL5</accession>
    <name>A0A5N4AIL5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PPYR_08148</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">1611_PpyrPB1</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the protein-tyrosine phosphatase family. Non-receptor class 4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AIL5"/>
    <dbReference type="FunCoup" id="A0A5N4AIL5">
        <property type="interactions" value="1480"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AIL5"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050839">
        <property type="term" value="F:cell adhesion molecule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004726">
        <property type="term" value="F:non-membrane spanning protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030971">
        <property type="term" value="F:receptor tyrosine kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048666">
        <property type="term" value="P:neuron development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070374">
        <property type="term" value="P:positive regulation of ERK1 and ERK2 cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14544">
        <property type="entry name" value="PTPc-N11_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10340">
        <property type="entry name" value="SH2_N-SH2_SHP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000018">
        <property type="entry name" value="Tyrosine-protein phosphatase non-receptor type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000045">
        <property type="entry name" value="Tyrosine-protein phosphatase non-receptor type 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46559:SF3">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46559">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 11" id="KW-0727">SH2 domain</keyword>
    <feature type="domain" description="SH2" evidence="13">
        <location>
            <begin position="6"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="14">
        <location>
            <begin position="129"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="15">
        <location>
            <begin position="318"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="481"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAB0797154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="540" mass="61665" checksum="014D7A42D293A5EF" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AJM9</accession>
    <name>A0A5N4AJM9_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_08497</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AJM9"/>
    <dbReference type="InParanoid" id="A0A5N4AJM9"/>
    <dbReference type="OrthoDB" id="6572538at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0797504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="311" mass="36005" checksum="5F083E675D08786B" modified="2020-02-26" version="1">MTLFTIVIYFCIDYIKGLRMDYDPRIKLNIFQGQTTFQNDYRRFTPDSREKYVWPKARSEPPPKKSAEFIRKDPETFVEWNKDVYIPFNLLMKPRPIIDTTPYATIPRLKDQAKDAEKSDVMKSRPRLYMTPAVSMDDVPDPEMRKLICDYMYTTDFRRAEKEAAMGENTREIATSTLDVGLDPVKLRTELYPPLPLGWREKGRAWDSRQMRALVDPTETFWFKRGSRVKCGACNNPYKGAVPQSVKDEIATLIRKDKLRLAHDYPIPGYTGLRPMLSAGVPLSKTDLPVTHPFLSASQAVTQRYAEDKNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AJT9</accession>
    <name>A0A5N4AJT9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DEUBAD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PPYR_08559</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Asx family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A5N4AJT9">
        <property type="interactions" value="518"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AJT9"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035517">
        <property type="term" value="C:PR-DUB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026905">
        <property type="entry name" value="ASX-like_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024811">
        <property type="entry name" value="ASX/ASX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028020">
        <property type="entry name" value="ASX_DEUBAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044867">
        <property type="entry name" value="DEUBAD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13578">
        <property type="entry name" value="ADDITIONAL SEX COMBS LIKE PROTEIN ASXL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13578:SF20">
        <property type="entry name" value="POLYCOMB PROTEIN ASX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13919">
        <property type="entry name" value="ASXH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13922">
        <property type="entry name" value="PHD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51916">
        <property type="entry name" value="DEUBAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DEUBAD" evidence="11">
        <location>
            <begin position="158"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="42"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="269"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="419"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="514"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="564"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="926"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1109"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="52"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="514"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="576"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="926"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="937"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1112"/>
            <end position="1126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAB0797566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1286" mass="141409" checksum="68B0F64AAAD69E7D" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AK53</accession>
    <name>A0A5N4AK53_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Muscle M-line assembly protein unc-89</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PPYR_08591</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="interactions" value="38"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="10260894at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040017">
        <property type="term" value="P:positive regulation of locomotion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060298">
        <property type="term" value="P:positive regulation of sarcomere organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045989">
        <property type="term" value="P:positive regulation of striated muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="match status" value="6"/>
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        <property type="entry name" value="Cardiac titin"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Myosin light chain kinase"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Myosin light chain kinase, smooth muscle"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Myosin, light chain kinase a"/>
        <property type="match status" value="3"/>
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        <property type="entry name" value="palladin isoform X1"/>
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        <property type="match status" value="2"/>
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        <property type="entry name" value="Uncharacterized protein, isoform F"/>
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        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="22"/>
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        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
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    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
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        <property type="entry name" value="Ser/Thr_kinase_AS"/>
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        <property type="entry name" value="IMMUNOGLOBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47633:SF7">
        <property type="entry name" value="TITIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="IG"/>
        <property type="match status" value="20"/>
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        <property type="entry name" value="IGc2"/>
        <property type="match status" value="17"/>
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        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="20"/>
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    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
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        <property type="match status" value="2"/>
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        <property type="match status" value="20"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="9699"/>
            <end position="9714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="9716"/>
            <end position="9725"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="10380"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAB0797598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="10840" mass="1198571" checksum="AC9B0214A79CB8F3" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AKN9</accession>
    <name>A0A5N4AKN9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">COP9 signalosome complex subunit 9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_08859</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CSN9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AKN9"/>
    <dbReference type="FunCoup" id="A0A5N4AKN9">
        <property type="interactions" value="150"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AKN9"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029391">
        <property type="entry name" value="CSN9_metazoa"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28562">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15004">
        <property type="entry name" value="MYEOV2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0736">Signalosome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0797866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="59" mass="6502" checksum="1E404A10DEF9F12F" modified="2020-02-26" version="1">MKPAIVADEMFPEGAGPYMDLEEAGGSSNLLMDLAASEITIHADFFNDFDDLYDDEDLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AKT4</accession>
    <name>A0A5N4AKT4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Immediate early response 5 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_08955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IER family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AKT4"/>
    <dbReference type="InParanoid" id="A0A5N4AKT4"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008653">
        <property type="entry name" value="IER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15895">
        <property type="entry name" value="IMMEDIATE EARLY RESPONSE GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05760">
        <property type="entry name" value="IER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0797962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="257" mass="28320" checksum="22B9FCFECF815848" modified="2020-02-26" version="1">MATEAQRLIGISLSKIAQSRANRGGVSLHKNLLVATVLQKARYVFMEEAYNMQRRAIPEDNLVGLTAEEAGIEPLRIAEDVQEASTSESSLPEFLQPCVRCTESQDKENQPPTYHSSTELTYLDLDKSSNVLRERSNSGLKRRRAVAEWETEEAVQSILPKRSKSDDEDDSVFLDDATILSDVVSKEVEAERAQTTPPGSAMEIDRITSLVSIFSFGMSEGGGSKLNRSVSTPDLCSAQAKDSDDSLQQRPYLAMTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ALI7</accession>
    <name>A0A5N4ALI7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Lipid-binding serum glycoprotein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_09182</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ALI7"/>
    <dbReference type="InParanoid" id="A0A5N4ALI7"/>
    <dbReference type="OrthoDB" id="6747947at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.30">
        <property type="entry name" value="Haemolymph juvenile hormone binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010562">
        <property type="entry name" value="Haemolymph_juvenile_hormone-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038606">
        <property type="entry name" value="To_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008">
        <property type="entry name" value="PROTEIN TAKEOUT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008:SF9">
        <property type="entry name" value="PROTEIN TAKEOUT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06585">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00700">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024295505" description="Lipid-binding serum glycoprotein N-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="16"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0798189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="223" mass="24291" checksum="ED5B25FD5236E0C4" modified="2020-02-26" version="1">MLLTYFIAIFAFASANTVVPIVSTRGFLEDQINNTLNKVAADLAKKDPYIIPELTQTIDNGTIRLNFTAKDMQVHGISKFVAKELKVTMFPPTIAIVIAFENLTVSIGEYDLSMKASFVPLYGHGNLTLTSQNIVLNCSAAASFSPLGIKDLNLGFNLDTVDLHVTGLLNNEGFSQIISSAISEVLPGYVQKYGVVIGKLISKPVEDLINDLIPIKLTRVKMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AMT4</accession>
    <name>A0A5N4AMT4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Triokinase/FMN cyclase</fullName>
            <ecNumber evidence="2">2.7.1.28</ecNumber>
            <ecNumber evidence="1">2.7.1.29</ecNumber>
            <ecNumber evidence="3">4.6.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (cyclizing)</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PPYR_09609</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">1611_PpyrPB1</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde, and the splitting of ribonucleoside diphosphate-X compounds among which FAD is the best substrate. Represses IFIH1-mediated cellular antiviral response.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>D-glyceraldehyde + ATP = D-glyceraldehyde 3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13941"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.28"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>FAD = riboflavin cyclic-4',5'-phosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13729"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:76202"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="4.6.1.15"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>dihydroxyacetone + ATP = dihydroxyacetone phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15773"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16016"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.29"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Homodimer. Interacts with IFIH1 (via the CARD domains), the interaction is inhibited by viral infection.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.28" evidence="2"/>
    <dbReference type="EC" id="2.7.1.29" evidence="1"/>
    <dbReference type="EC" id="4.6.1.15" evidence="3"/>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AMT4"/>
    <dbReference type="InParanoid" id="A0A5N4AMT4"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034012">
        <property type="term" value="F:FAD-AMP lyase (cyclizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004371">
        <property type="term" value="F:glycerone kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050354">
        <property type="term" value="F:triokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10440:FF:000001">
        <property type="entry name" value="Dihydroxyacetone kinase, DhaK subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10440">
        <property type="entry name" value="Dihydroxyacetone kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1180.20">
        <property type="entry name" value="Dihydroxyacetone kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004006">
        <property type="entry name" value="DhaK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004007">
        <property type="entry name" value="DhaL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036117">
        <property type="entry name" value="DhaL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050861">
        <property type="entry name" value="Dihydroxyacetone_Kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28629">
        <property type="entry name" value="TRIOKINASE/FMN CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28629:SF4">
        <property type="entry name" value="TRIOKINASE_FMN CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02733">
        <property type="entry name" value="Dak1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02734">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01120">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82549">
        <property type="entry name" value="DAK1/DegV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101473">
        <property type="entry name" value="DhaL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51481">
        <property type="entry name" value="DHAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51480">
        <property type="entry name" value="DHAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0170">Cobalt</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DhaK" evidence="17">
        <location>
            <begin position="20"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="DhaL" evidence="16">
        <location>
            <begin position="377"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00046681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAB0798616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="575" mass="64208" checksum="BA3B975D656DEC23" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ANR2</accession>
    <name>A0A5N4ANR2_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Synembryn</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PPYR_06824</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cell cortex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the synembryn family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0798944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ANR2"/>
    <dbReference type="FunCoup" id="A0A5N4ANR2">
        <property type="interactions" value="1738"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4ANR2"/>
    <dbReference type="OrthoDB" id="5585685at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001965">
        <property type="term" value="F:G-protein alpha-subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008376">
        <property type="entry name" value="Chaperone_Ric-8_A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019318">
        <property type="entry name" value="Gua_nucleotide_exch_fac_Ric8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12425">
        <property type="entry name" value="SYNEMBRYN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12425:SF5">
        <property type="entry name" value="SYNEMBRYN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10165">
        <property type="entry name" value="Ric8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01802">
        <property type="entry name" value="SYNEMBRYN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0798944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="533" mass="60273" checksum="6C4F9DA7861AB8E4" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4APX4</accession>
    <name>A0A5N4APX4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_07285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4APX4"/>
    <dbReference type="InParanoid" id="A0A5N4APX4"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF2">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="121"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0799405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="338" mass="39208" checksum="25B734F83849B41F" modified="2020-02-26" version="1" fragment="single">MVQKEVFTDKNKSFPFNVEKDTSGLLRVKTRITMRKDSDYFVRPILLPSRHPVVDALIHEEHLDKCHAGVQYLVSHLREKVWILKGRKAIQHVIRNCVKCRRFRRKAPDPIMAPLPENRVRDAHPFEIIGIDYAGPMYLKDGSKVCVALYTCAVYRAVHLELVTNLTTEAFLMSLRRFVARNGRPSVIYTDNGTNFVGANRLLAGLEWGRIEKETSVQKIKWILNPPSAPWYGGWFERLVRTMKELLVRVLGSSILNYEELVTVLCDVQGVINGRPLTYVFENDDLLPLTPSMFLQGVREVGVPDIDMLDNKGFQKRYRLRQRLMNDLRHRFRKEYIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AQ52</accession>
    <name>A0A5N4AQ52_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_07337</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AQ52"/>
    <dbReference type="InParanoid" id="A0A5N4AQ52"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22954:SF3">
        <property type="entry name" value="PROTEIN CBG08539"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22954">
        <property type="entry name" value="RETROVIRAL PROTEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0799457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="117" mass="13886" checksum="3C47DC38BEC6BD5D" modified="2020-02-26" version="1">MKIWKVNIMPVNNLKTSIIQQYHVRKVYYKAIMQKMRQAQVLTKIIIKTAISESSDWLQFRDSFESLINNNSRITNVQRFHYLKRALQGEAFESIANIQVTNDNFSIAWELLRSLKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AQ86</accession>
    <name>A0A5N4AQ86_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">aralkylamine N-acetyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.87</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PPYR_07351</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">1611_PpyrPB1</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>dopamine + (9Z)-octadecenoyl-CoA = N-(9Z-octadecanoyl)-dopamine + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51380"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:31883"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:59905"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:51381"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>dopamine + acetyl-CoA = N-acetyldopamine + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51388"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:59905"/>
            <dbReference type="ChEBI" id="CHEBI:125678"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:51389"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>dopamine + hexadecanoyl-CoA = N-hexadecanoyl-dopamine + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51376"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:59905"/>
            <dbReference type="ChEBI" id="CHEBI:134058"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:51377"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>serotonin + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = N-[(5Z,8Z,11Z,14Z)-eicosatetraenoyl]-serotonin + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51396"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57368"/>
            <dbReference type="ChEBI" id="CHEBI:132255"/>
            <dbReference type="ChEBI" id="CHEBI:350546"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:51397"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>serotonin + (9Z)-octadecenoyl-CoA = N-(9Z-octadecenoyl)-serotonin + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51392"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:134064"/>
            <dbReference type="ChEBI" id="CHEBI:350546"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:51393"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>serotonin + acetyl-CoA = N-acetylserotonin + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25217"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17697"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:350546"/>
            <dbReference type="EC" id="2.3.1.87"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:25218"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>serotonin + hexadecanoyl-CoA = N-hexadecanoyl-serotonin + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51384"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:134059"/>
            <dbReference type="ChEBI" id="CHEBI:350546"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:51385"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>serotonin + octadecanoyl-CoA = N-octadecanoyl-serotonin + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51400"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57394"/>
            <dbReference type="ChEBI" id="CHEBI:134065"/>
            <dbReference type="ChEBI" id="CHEBI:350546"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:51401"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Aromatic compound metabolism; melatonin biosynthesis; melatonin from serotonin: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the acetyltransferase family. AANAT subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.87" evidence="5"/>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AQ86"/>
    <dbReference type="FunCoup" id="A0A5N4AQ86">
        <property type="interactions" value="20"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AQ86"/>
    <dbReference type="OrthoDB" id="41532at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004059">
        <property type="term" value="F:aralkylamine N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000046">
        <property type="entry name" value="Dopamine N-acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20905:SF1">
        <property type="entry name" value="AT07410P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20905">
        <property type="entry name" value="N-ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="14">
        <location>
            <begin position="38"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00050189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00050849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00052178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00052491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAB0799471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="250" mass="28381" checksum="414FE1FDE6F488D7" modified="2020-02-26" version="1">MDIVNLDPRILFAKVAVGEVPCALFWDSAELAGTSMDYEIRIVTEEDTEAVLELLKKNFFLDEPLNDYVKLIEFKDSTCEELEQFCKEKIHEKNSVMAITPSGQILGVSLNGTLEEDYGDVEQCQNPKFKKILKLLNHCAKIFQPIFNERFPKSSKVLNIRVLSSDSAWRGQGIAGALIKRSRQIAQEQGYDLIRVDCSSHFSARAVSKLGYELVYELKYEDYKDNGEVVFKLPHPHTCVAFFIQSTTSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AQK1</accession>
    <name>A0A5N4AQK1_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_07512</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AQK1"/>
    <dbReference type="InParanoid" id="A0A5N4AQK1"/>
    <dbReference type="OrthoDB" id="6595846at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23992">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.20">
        <property type="entry name" value="Pheromone/general odorant binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006170">
        <property type="entry name" value="PBP/GOBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036728">
        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01395">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00708">
        <property type="entry name" value="PhBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024449836" evidence="1">
        <location>
            <begin position="17"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0799632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="151" mass="16613" checksum="0BC27F5ADFA841CA" modified="2020-02-26" version="1">MKCVISLLFLFTAAYGVSDEFKNALRMKMATFASACISEVGAGEADITDLVRKRIPSTREGRCLISCLQKKFGLQQSDGQPDRLGTMALLEPLHDDDPEMYKKVLQVAITCGPLVEKMKLTDACDVAVEVTTCAMREGKKFGLEDPFGLNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-06-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ARB2</accession>
    <name>A0A5N4ARB2_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_07765</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ARB2"/>
    <dbReference type="InParanoid" id="A0A5N4ARB2"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0799885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="91" mass="10213" checksum="83A1D2245AF83C0D" modified="2020-02-26" version="1">MVVDYHDFISSGGKLPTTQLFLRGSKVIAFHSLGQLNNYHFLHPQTGASYATLNTLRSSLAFIIPTNLALDTKIKRFFRGVQMLRPSAPNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AT03</accession>
    <name>A0A5N4AT03_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_06186</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000004">
        <property type="protein sequence ID" value="KAB0800446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AT03"/>
    <dbReference type="InParanoid" id="A0A5N4AT03"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0800446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="69" mass="8201" checksum="673D60B1620EEEED" modified="2020-02-26" version="1">MTTEDQEMMRTIINYNADLANLEDNCRGIIKNSPLNEIPSFHVVKNFYVDIMHDIFEGFRNFKLKETKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AV83</accession>
    <name>A0A5N4AV83_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_05502</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000003">
        <property type="protein sequence ID" value="KAB0801148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AV83"/>
    <dbReference type="InParanoid" id="A0A5N4AV83"/>
    <dbReference type="OrthoDB" id="69711at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0801148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="388" mass="43440" checksum="50804DC31549E655" modified="2020-02-26" version="1">MEKEQCQFNSFSGPLTLTEIKKALSIKKSPQSIQRRASISDLNPSRNIFFEYPELYLWSKMNLSNGDDDVDLDSSVQVIHDPPIVVSPNISSSSKYIQQISEILQVSDSEKDTTCDNKSGILRLCSDSVIIISDDEESYEQLTTSLNSTQSSLFELKDSGFTNLGSTSTEDVKFNDTIEEMEKFLKEAATYSNETMSPIHPSTPLTKINTSNDKSDSFKKPLSKIPIVTKKNLVKKSPCVTKTPHYKDIVSPVAIYIKNSPHVPLIQNVPTKQLSQKNLFPSQKLPNNDNDWENLLPSVIYAPPRKIQSTSEPSLKLPINIHCHLPTTPRIIKHKGRLAGTNRLDVEEKLVDDGDLSLSVLSELDNTVPLQEISVHTCKELLMMPSKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AVM6</accession>
    <name>A0A5N4AVM6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_05667</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000003">
        <property type="protein sequence ID" value="KAB0801313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AVM6"/>
    <dbReference type="FunCoup" id="A0A5N4AVM6">
        <property type="interactions" value="2868"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AVM6"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21370">
        <property type="entry name" value="cwf21_SR140"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12223">
        <property type="entry name" value="RRM_SR140"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.790">
        <property type="entry name" value="Surp module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013170">
        <property type="entry name" value="mRNA_splic_Cwf21_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051485">
        <property type="entry name" value="SR-CTD_assoc_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047488">
        <property type="entry name" value="SR140_cwf21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035009">
        <property type="entry name" value="SR140_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000061">
        <property type="entry name" value="Surp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035967">
        <property type="entry name" value="SWAP/Surp_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23140">
        <property type="entry name" value="RNA PROCESSING PROTEIN LD23810P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23140:SF0">
        <property type="entry name" value="U2 SNRNP-ASSOCIATED SURP MOTIF-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04818">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08312">
        <property type="entry name" value="cwf21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01805">
        <property type="entry name" value="Surp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01115">
        <property type="entry name" value="cwf21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00582">
        <property type="entry name" value="RPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00648">
        <property type="entry name" value="SWAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109905">
        <property type="entry name" value="Surp module (SWAP domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50128">
        <property type="entry name" value="SURP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="185"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="SURP motif" evidence="5">
        <location>
            <begin position="335"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="CID" evidence="6">
        <location>
            <begin position="438"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="693"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="711"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="741"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="764"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="847"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="863"/>
            <end position="899"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0801313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="924" mass="106241" checksum="56CF09B9ABB333C9" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AWD0</accession>
    <name>A0A5N4AWD0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="6">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PPYR_03749</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0801563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AWD0"/>
    <dbReference type="InParanoid" id="A0A5N4AWD0"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142:SF1">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024449633" description="Carboxylic ester hydrolase" evidence="6">
        <location>
            <begin position="19"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="7">
        <location>
            <begin position="22"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0801563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="313" mass="34623" checksum="9B4EDECAEFA9848E" modified="2020-02-26" version="1" fragment="single">MIMYCLILLSTLVWLSRGHSSNPIVTTPSGAVKGSIMTSAQEKTIFAFRGIRYAEPPIGEWRFKPPRPVIPWNLTYDATKDGYACPQPSSWPTYEDCLFLNVYTTKLPRHGRNPKRPVLVYFHAGGFYSVDGTSKFAGPEYLLDQELVLVTLNYRLASLGFLSTGDSLAPGNNGLKDQVAAMRWIQVNIESFGGDPNSVTISGYSAGGMSVTLHMVSPMSKGLFHKAIAMSGSALAQWAIPDHQFHLAQRQARLVGCPDDTSLKIINCLKTKTAKELGDSLPGFSEYRSDPIIKWKPVIEKDFGQERFLVEDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AWU4</accession>
    <name>A0A5N4AWU4_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_03997</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0801811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AWU4"/>
    <dbReference type="InParanoid" id="A0A5N4AWU4"/>
    <dbReference type="OrthoDB" id="7776589at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="entry name" value="Intergrase catalytic core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0801811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="465" mass="53733" checksum="7CC2E7F5BE8D13CE" modified="2020-02-26" version="1">MFIGGMSTLVAEINDLVNNKDADNIPCSSLLPEKSKMRYNQLYDAFAKWCSAKDIKKTTENVMMAYFMERSEVLKSPASLWSEYSMLKLTISIQQNEDISKFKRLKAFLKRKNDGYQPRTSKIFKREEIEKFIAEAPDEIYLLMKIVAIMGVVGACHTGELHKIKFKDIDLKDDVAIVRILETRNTIRRSFIITNNSEGSSDWLKLLQTYMKLRPYNAVDERLFFRYERGRCVNQVVGRNTISKVPREIAKYLKLDNVYEYTGRAFRKSSATFLSNVYDTFARSRCRSSNTIVKSVTSQSTRSDISAIGKDLEMNAFENITQEFQNSNDTQKSITFSCEDSRHSLSQESDISQGRCDSDYKYVMDDSEIHLTNEITHSPIPVKLEHRSDEESTNESTPSILTDVIIPNKKVNEARPSVFKNDSDLFFKMVAAKVRRFSPYHKNLIETKIFSLVQEMELEQIQQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AZD7</accession>
    <name>A0A5N4AZD7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Angiotensin-converting enzyme</fullName>
            <ecNumber evidence="12">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PPYR_04814</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11 12">Belongs to the peptidase M2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="12"/>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AZD7"/>
    <dbReference type="FunCoup" id="A0A5N4AZD7">
        <property type="interactions" value="72"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AZD7"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008241">
        <property type="term" value="F:peptidyl-dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06461">
        <property type="entry name" value="M2_ACE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001548">
        <property type="entry name" value="Peptidase_M2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10514">
        <property type="entry name" value="ANGIOTENSIN-CONVERTING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10514:SF40">
        <property type="entry name" value="ANGIOTENSIN-CONVERTING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01401">
        <property type="entry name" value="Peptidase_M2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00791">
        <property type="entry name" value="PEPDIPTASEA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52011">
        <property type="entry name" value="PEPTIDASE_M2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="3 9 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="12" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8 12" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="471"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor 1" evidence="5">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor 2" evidence="6">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor 1" evidence="5">
        <location>
            <position position="332"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor 2" evidence="6">
        <location>
            <position position="332"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>chloride</name>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>chloride</name>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="9 11">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9 11">
        <location>
            <begin position="357"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601548-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601548-11"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601548-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601548-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601548-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601548-8"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAB0802628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="492" mass="57423" checksum="846BCDC6A74D2E24" modified="2020-02-26" version="1">MIIGSDFLVTGQYGVRLVRQHTKHMLLTFILDFTDTADYWMFPYESPSLTHDLEEAWETVKPLYELLHAYVRRRLRDFYGPEKINRRAPLPAHVLGNMWGQSWSHIFDISQPYPGRDFLDVGPEMIRQGYSPVDIFRLAEDFFVSMNFSALPLDFWSGSLLQEPADRVVLCQPSAWDFCNREDFRIKMCTRINMKDLITAHHELAHIHYFIQYRNLPKVFRDGANPAFHEAIGEAIGLSVGTPRHLQALGLVQTSVDDSAVNINYLYMMALDKVAFLPFTYLMDKWRYDVFKGDIYKDQYNCHWWRLSELYTGIKPPVLRSEMDFDPGSKYHIAANIPYMRFFVSTLLQFQLYRALCRAAGQYDSLNINQPLHKCDIYRSKEAGLVLRRLMEKGSSLPWNEVLFQAIGESRLDGNAMREYFRPLEDWLRNENLRTQEYVGWVYDGDYCKQSIETAGLQVYGGFYNGAYAALQSYTVLIISIWASISLYILKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B078</accession>
    <name>A0A5N4B078_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Dynein regulatory complex subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Coiled-coil domain-containing protein 65</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PPYR_05104</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">1611_PpyrPB1</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Plays a critical role in the assembly of N-DRC and also stabilizes the assembly of multiple inner dynein arms and radial spokes. Coassembles with DRC1 to form a central scaffold needed for assembly of the N-DRC and its attachment to the outer doublet microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Flagellum axoneme</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
            <location evidence="8">Cytoskeleton</location>
            <location evidence="8">Flagellum basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DRC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B078"/>
    <dbReference type="InParanoid" id="A0A5N4B078"/>
    <dbReference type="OrthoDB" id="7760980at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005858">
        <property type="term" value="C:axonemal dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070286">
        <property type="term" value="P:axonemal dynein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060285">
        <property type="term" value="P:cilium-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003352">
        <property type="term" value="P:regulation of cilium movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039505">
        <property type="entry name" value="DRC1/2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039750">
        <property type="entry name" value="DRC1/DRC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21625:SF0">
        <property type="entry name" value="DYNEIN REGULATORY COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21625">
        <property type="entry name" value="NYD-SP28 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14772">
        <property type="entry name" value="NYD-SP28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0969">Cilium</keyword>
    <keyword evidence="4 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0282">Flagellum</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynein regulatory complex protein 1/2 N-terminal" evidence="15">
        <location>
            <begin position="14"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="123"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="246"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF14772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAB0802918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="450" mass="53873" checksum="BC518F87DDE71913" modified="2020-02-26" version="1">MPLSPEEKAALKLQKKEQKKRDEEFKRRKIKHDEISREVKYGRLTLKSNERKWRRMLIEISLPRMRSELEYAWHNFERIIDVKDFTISYLLDELDQAEEQYVANVKCHSEHIDDLIHRFNNYLQELKFENEGHLNKLQDQTNREVEEIERNAAEADEYFKTMLFGLEAAKKEQELRVRGEYLSKIDEESTKYKNIIRELRAVLEKNYADLWVAIKLFLYDFEQQTMERRKSYNILASQDELLQKVCLNQNLKLIRMQDALKNLKRQYSQAQKSQKQKLTDLLNEQQYFSDAFTTLKGRMNNDKRIDSTNLTLLTEESSIIWMHLKKILEKGRKAQQLAGFCRKLETLREKTLPFPKYDTDDDEVQIEEHPATASLELFWKRVAQADAIRHGINEEREYLKRENRMLQIQIHNYCMCVDCPGLESENHKQTSGKPTVTEGDLMRKQYDKFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B089</accession>
    <name>A0A5N4B089_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_05198</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0803012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B089"/>
    <dbReference type="InParanoid" id="A0A5N4B089"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861:SF1">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="1">
        <location>
            <begin position="40"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0803012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="144" mass="16805" checksum="FD8C973CBBA3BF6E" modified="2020-02-26" version="1">MNKVGPFLKHVAPYQLQYNINVLKNYFPLIRDRHNVKSALDVGCGPGDLTSAVFQFVEQDINEMIGIDISPVMVDWANKAYGGDRIYFSKVDVQTIPKNFENRFDCIFSFWTLHWIADQRTLYYNISKMLKQRRSFLVSYIPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B1V2</accession>
    <name>A0A5N4B1V2_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_00535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B1V2"/>
    <dbReference type="InParanoid" id="A0A5N4B1V2"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="entry name" value="Intergrase catalytic core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0803565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="116" mass="12969" checksum="4D749F40A2D01E2D" modified="2020-02-26" version="1">MKVLLIIGYSGASRREELLNIHMTDIAHTDNNILIRITKTKNNIQRQFAISNPRWVKLVQDNSQPSTSTLQGPPLQKTMISNTTTEIDHLAGISVHAAENSVVTIKVYNNCTITEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B1Y1</accession>
    <name>A0A5N4B1Y1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Caprin-1 dimerization domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_00536</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the caprin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B1Y1"/>
    <dbReference type="InParanoid" id="A0A5N4B1Y1"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028816">
        <property type="entry name" value="Caprin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041637">
        <property type="entry name" value="Caprin-1_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22922:SF19">
        <property type="entry name" value="CAPRIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22922">
        <property type="entry name" value="GPI-ANCHORED PROTEIN P137"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18293">
        <property type="entry name" value="Caprin-1_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Caprin-1 dimerization" evidence="3">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="191"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="235"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0803566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="268" mass="29986" checksum="635AD6E952F34DD0" modified="2020-02-26" version="1">MLDDLYPVVTPKHEPGDATAFANQVQAAAEHLLAVVDGKQKEVFDGSYSQIKEVIGKIHESGYFDQAVAADYETTEVNDADQHCNIEVPQQIEPLEEEIPAVDTVTIETNRPVPLPIEHPLEQIQQTDQQIYYQPPPRPISEVLGPGSFHFLQDSELDTPDTLPSQTFTNTSYVQAPPPPIPLPPNFQTFNNINVPPPGNGMNEEIAPPSVVAHPQPQQIEESQKMRGQPPRPPNQMYYQNNHSNSNNYNNNRPRQPRSGPRTANRHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B207</accession>
    <name>A0A5N4B207_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Olfactomedin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PPYR_00566</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B207"/>
    <dbReference type="InParanoid" id="A0A5N4B207"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003112">
        <property type="entry name" value="Olfac-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050605">
        <property type="entry name" value="Olfactomedin-like_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23192:SF85">
        <property type="entry name" value="GLIOMEDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23192">
        <property type="entry name" value="OLFACTOMEDIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02191">
        <property type="entry name" value="OLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00284">
        <property type="entry name" value="OLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51132">
        <property type="entry name" value="OLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Olfactomedin-like" evidence="5">
        <location>
            <begin position="1"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0803596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="254" mass="29863" checksum="8B6375D784B8262D" modified="2020-02-26" version="1">MIYGSWMKDSSPSNDADGEKYWITNEHEPSKLYEFDNKNVFRKSNATRTYKLEIPFQGNAHVIYNGSFYYQALGKPKIIRYFLNNESKMEIGVPKLNVTNENYLYKTENNYLDFSVDDNGLWVVFPVPDANNTAVMKIDISSMQIQYIWNISIDHHLVGEMFVVCGVLYAIDSVTERNTRIRFALDLYNNRLLDINLSFTNPFSRTTMVGYNHRNKELFSWDKGNQLTYPIRYNEIGNYTNRDDILEHNEFLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B246</accession>
    <name>A0A5N4B246_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein quiver</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_00637</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B246"/>
    <dbReference type="InParanoid" id="A0A5N4B246"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024297558" description="Protein quiver" evidence="1">
        <location>
            <begin position="21"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0803667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="115" mass="13067" checksum="BA27B0E8A04BF030" modified="2020-02-26" version="1">MYLKLVLASFGLICVGVASGSTSTTCYTCFGIEDESSQELLNCRRMINITATDRCSGSPRAYCIFYYGNTIRNQPVVTRAVRKCSLYDCQYYREWSAANLHCSHCEESYCNIFQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B2F6</accession>
    <name>A0A5N4B2F6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Retropepsins domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_00678</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B2F6"/>
    <dbReference type="InParanoid" id="A0A5N4B2F6"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0803708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="338" mass="37361" checksum="EB9EA2F903FB5CDE" modified="2020-02-26" version="1">MLNVSSTTDQERPMLPIRIHQFHGSACLDTGSKTSIAGAQLYKLLISCGEPFIDKDVTIKLADGNERRVIAKQFNIVIHLQSKEIQTSMLAIPEFVNSRTLLGADFIKAAGMILDFAQNNWFFSNNPETRYGFLTEEIANSVPIDAIQGSDLSLRAHEGETLHNNEHDRINPLLNEFADTLSRPPRHSDSICTAAVDLPVTDGSKIRSLQLEDADLRKIIEALESTDDPEQDHAKSYADTKRIPGPNYKVGDKVLVATHALSNAKQGYTAKFAPRRDGPYVIMKKVSPSAFQISSLQSPDVPLGTYHTSSLTPFTNNSVNSDPAPVRPIRKKGRPKRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B2M0</accession>
    <name>A0A5N4B2M0_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_00831</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B2M0"/>
    <dbReference type="FunCoup" id="A0A5N4B2M0">
        <property type="interactions" value="43"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4B2M0"/>
    <dbReference type="OrthoDB" id="272202at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001534">
        <property type="term" value="C:radial spoke"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035082">
        <property type="term" value="P:axoneme assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060294">
        <property type="term" value="P:cilium movement involved in cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22963">
        <property type="entry name" value="DD_CrRSP4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006802">
        <property type="entry name" value="Radial_spoke"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13159:SF0">
        <property type="entry name" value="RADIAL SPOKE HEAD 6 HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13159">
        <property type="entry name" value="RADIAL SPOKEHEAD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04712">
        <property type="entry name" value="Radial_spoke"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0969">Cilium</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="202"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="338"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="406"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="548"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="205"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="343"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="414"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="431"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="553"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0803861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="570" mass="64735" checksum="5676FF2A9EACE815" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B5I9</accession>
    <name>A0A5N4B5I9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_01784</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B5I9"/>
    <dbReference type="InParanoid" id="A0A5N4B5I9"/>
    <dbReference type="OrthoDB" id="6760977at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24241">
        <property type="entry name" value="NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="220"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="8">
        <location>
            <begin position="33"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0804814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="361" mass="41287" checksum="FAC4087F4065D04C" modified="2020-02-26" version="1">MKMENFTESNSGEESATLSLWIIISYYCFVLIGLILNVCISICLIQRKERGIFSLILHLTIVDCLSTFVAVIEIWIINNHSWVLPSKLCRFFSGSEVLINTFVLYETICINFHITSTLNLYLQEIRNDGKSPISLSEEEDSDQFLVSHEEEHYNRNVVIDYRRKKTDIAILVPLFLVWFVGLSVSIPQLTLSTPVTVENSVVLCTIFDTFHKRLLQNLSVAFRIIIPLPLLFLSLVILITRSYQSMHLKNVGQNLLARKTKKVQSMLVLGTVLTILYVTVSLQRQILAILHFIAQEINAAGSLSNFKIPPLQNVTCSNLTNLLSAMAHYACSTLRPIIYILVLPELRYMFRFSEKLKCYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B5Z1</accession>
    <name>A0A5N4B5Z1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_01946</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B5Z1"/>
    <dbReference type="InParanoid" id="A0A5N4B5Z1"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF85">
        <property type="entry name" value="GH03217P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="8">
        <location>
            <begin position="75"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0804976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="276" mass="31743" checksum="EECECBD75EB6F4BA" modified="2020-02-26" version="1" fragment="single">IIFLGHGAYQKVVGHNFMLSMAQNTVSNCIQEISHLIVHYLSDEWIQFPTTEEEKLAIKVKFRETTHFPGVIGAVDCTHVAIIAPREEEHNFINRKGYHSKNIQIICDYNLKILNINPQFAGATHDAYIWRNSEVHQELERCYLAGDRHSWLLGDSGYPQQPWLMTPVLNALAGSAEERYNTHHASARNCIERCNGVFKQRFRCVLGERTLRYSPEKVGNIVVACAVLHNICTDARLELDVENMERIIPNEVNVNVQQMNENGRDARRILIENYFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B621</accession>
    <name>A0A5N4B621_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_02031</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0805061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B621"/>
    <dbReference type="InParanoid" id="A0A5N4B621"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="138"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="758"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="778"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="808"/>
            <end position="818"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0805061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="860" mass="98509" checksum="38111C29A49C2039" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B696</accession>
    <name>A0A5N4B696_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed DNA polymerase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_02056</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0805086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B696"/>
    <dbReference type="InParanoid" id="A0A5N4B696"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.60">
        <property type="entry name" value="N-acetyl transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511">
        <property type="entry name" value="PROTEIN CBG23764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511:SF12">
        <property type="entry name" value="RHO TERMINATION FACTOR N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="His-Me finger endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0805086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="987" mass="114298" checksum="DDE56DB2311EC012" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B7V7</accession>
    <name>A0A5N4B7V7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Collagen IV NC1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_02642</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0805672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B7V7"/>
    <dbReference type="InParanoid" id="A0A5N4B7V7"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050938">
        <property type="entry name" value="Collagen_Structural_Proteins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37456:SF6">
        <property type="entry name" value="COLLAGEN ALPHA-1(XXIII) CHAIN-LIKE ISOFORM X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37456">
        <property type="entry name" value="SI:CH211-266K2.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="114"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="145"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0805672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="315" mass="31507" checksum="2DD3F1C75950381E" modified="2020-02-26" version="1">MFLTGPKGDRGESGTIGEPGLNGESGLQGPPGLPGQPGPKGEKGEYGDIGPPGLMGPPGLPGPPGYPGQKGEKGEKGESKYKKLRRRQGDGTGEVTIGGDMIMGPPGPPGPAGTPGLQGPPGIKGDKGVDGVKGEPGEKGTKGDPGPMGLPGPMGLRGEAGRPSDYTKPGPPGPPGLDGMKGAQGEPGSKGERGDPGLPGTDGIPGQEGPKGDKGYKGDAGPIGKRGRKGDKGDKGDQGVPGLDAPCPLGTDGLPLPGCGWRPPKEIHTISTPASDIDTEDPVDEDFEGDYDDQDDYEEYPEHTNSALAISASAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B841</accession>
    <name>A0A5N4B841_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CUB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_02676</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0805706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B841"/>
    <dbReference type="InParanoid" id="A0A5N4B841"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024340774" description="CUB domain-containing protein" evidence="3">
        <location>
            <begin position="23"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="4">
        <location>
            <begin position="30"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0805706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="416" mass="47204" checksum="A2067B9A7DD7CAEB" modified="2020-02-26" version="1">MDFYNYLCILLLGLFLINTGYTQSVTTVIPSEEVFIEDDNNHTWTSLNYPKPYPITNQTTILKVPNGYSIAVFVDDLDLDSGSGDFLLLKGGDKLKDENKGVVFTYTLKSARNYLIEQSSAYLAFQVHGNNTALKKGFSLRYTRKGKEVATTETPTTTILWPTPAAGDHMYLTVNVTGKSQEDFGNDTNLINFKNAIANMAIEYCSKHNISLSQNITIKNIHINTLTRCVYNWPESNMCVKIQLSIPVFLDTNSTLNGYQLSSGNLEQMWRDLADKWLPTVGMLVYQEPHSNSKLVLWLLISGTILICVTLGLFVVKALSRSAFTTAIKHTKRRYSDTKGIVENELKPRKTSLTPHPRQVIPPFFDNDTFFQYEPKMDTAPTDLYFFSDDSDEDVHFSKNRSQTLESKTNLRNLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1JYL3</accession>
    <name>A0A1Y1JYL3_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_11256</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
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                <person name="Shigenobu S."/>
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                <person name="Weng J.K."/>
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                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
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        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="JAV54414.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAB0794417.1"/>
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    </evidence>
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        <source>
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    <sequence length="110" mass="12069" checksum="723BB4C5335ECEC4" modified="2017-08-30" version="1">MDNRLEGSLGWLKDDYTTETTAIPEIIIAEEAAAGSLAVIIVSAIISITLLFIIAIFIDCRHQKAKNGKLRSRMFKITLPKFATPRVDQEPIADKMETEEATPAPATVIV</sequence>
</entry>
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    <accession>A0A1Y1K3E9</accession>
    <name>A0A1Y1K3E9_PHOPY</name>
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            <fullName evidence="6">DNA mismatch repair protein S5 domain-containing protein</fullName>
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    </protein>
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        <name evidence="8" type="ORF">PPYR_14854</name>
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    <organism evidence="7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
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        <lineage>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
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        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
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                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
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        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
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        </source>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA mismatch repair MutL/HexB family.</text>
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        <property type="molecule type" value="Transcribed_RNA"/>
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        <source>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="669" mass="76713" checksum="550C6A466FE8F0D6" modified="2017-08-30" version="1"> </sequence>
</entry>
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        <name evidence="6" type="ORF">PPYR_11742</name>
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            <taxon>Neoptera</taxon>
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            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
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    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
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            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
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        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
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                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
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            <dbReference type="PubMed" id="30324905"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
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        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
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        <property type="molecule type" value="Transcribed_RNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A1Y1KEX2"/>
    <dbReference type="InParanoid" id="A0A1Y1KEX2"/>
    <dbReference type="OrthoDB" id="9949424at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="CDD" id="cd00063">
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        <property type="entry name" value="Immunoglobulins"/>
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    <dbReference type="InterPro" id="IPR003961">
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        <property type="entry name" value="FN3_sf"/>
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        <property type="entry name" value="FNDC5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
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    <dbReference type="PANTHER" id="PTHR21104">
        <property type="entry name" value="FIBRONECTIN TYPE III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21104:SF2">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
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        <property type="entry name" value="DUF4808"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
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    </dbReference>
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    <sequence length="315" mass="34285" checksum="A78528FC7D9F14A1" modified="2017-08-30" version="1">MILLAAVILLNGAHIVGSMPGGPGVPENITVTFLNPTSVRVSWSTSVDNVYKYDVTYKPTDASYRVVAVVAGNSQAVTLSGLKADTQYQLTVAAVWGGKRYRSRPIVFRTLEPPRTSPQQDIMGVFATGVPSSPTNPEPPDFEYPQTSSTVRGVEIGIVLLVLVVWIGAIALFFNRWGKIRMLLPYQPDYKEQLKVPGTAACAAAVASGNTCSHNSGDHMCSQKCRAEKEVKIQSPHHQRSRTNSAIFISNSGPGFDSKEFMRRYGSISKLCRRARSVDNLSLEEEGHFGLPTLSISGPSPPGEDEPSETERFLQ</sequence>
</entry>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
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                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
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                <person name="Weng J.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
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        <source>
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    <sequence length="188" mass="21168" checksum="48E00FBF50325186" modified="2017-08-30" version="1">MATLLNQLKGIVNQIDDRGCCSTRCPQMSSPSFPFLQVCMLDPPCAVVPTEPKYVKPLQMPAPASACSNEVYDNEVEGLRTRAYNFYNNYNIDYHKTGHEFDYKPSKKRNLPYNATTVGGTFPNCPEDLQKNRTNRKMACPTGFKPCQMQLSPPPQCHPLGTWCASIRPCSPKARHRARECGTAKQKY</sequence>
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<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
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                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
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                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
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                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
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                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
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                <person name="Shigenobu S."/>
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                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
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        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
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                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
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                <person name="Debat H.J."/>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
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        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <proteinExistence type="predicted"/>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="248"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="369"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="396"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="JAV64197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0796122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="438" mass="49247" checksum="CE8F36179CD0EA14" modified="2017-08-30" version="1">MTSLSSTPLALTAASMIGNATTNIASDAVSPVKTATDSDPIFLQTTLAKAIAGTFVWAALFLTCQQIYHHLRWYTNPAEQRWIVRILFIVPIYATYSWVSLLFFNSESYYVYFFTVRDCYEAFVIYNFLSLCYEYLGGEGNIMSEIRGKPIRSSCMYGTCCLNGKTYTIGFLRFCKQATLQFCFVKPLMAFITIFLQAFDHYRDGDWSPDRGYLYITIIYNISISLALYGLFLFYFATRDLLTPFEPVLKFCTVKSVIFLSFWQGVALAILEKADIISPIIDSNGTRTSTGTVSAGYQNFLICIEMFCAAIALRYAFPHRVYAQGCVTDSRGRSVTMQSISSSLKETMNPKDIMTDAIHNFHPQYQQYTQYSSGGKNGRGMRISSYDPDDPMSPSGGTVTQSYNSVENASRSQSVGRVSTISQNYTEKTMLLSSDDEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1L250</accession>
    <name>A0A1Y1L250_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">L-serine ammonia-lyase</fullName>
            <ecNumber evidence="3">4.3.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">L-serine deaminase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">L-threonine dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PPYR_01195</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-serine = pyruvate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:19169"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="EC" id="4.3.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the serine/threonine dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.17" evidence="3"/>
    <dbReference type="EMBL" id="GEZM01066588">
        <property type="protein sequence ID" value="JAV67779.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1L250"/>
    <dbReference type="FunCoup" id="A0A1Y1L250">
        <property type="interactions" value="245"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1L250"/>
    <dbReference type="OrthoDB" id="4418812at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004794">
        <property type="term" value="F:threonine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006565">
        <property type="term" value="P:L-serine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:L-threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04886">
        <property type="entry name" value="ACT_ThrD-II-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01562">
        <property type="entry name" value="Thr-dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000007">
        <property type="entry name" value="L-threonine dehydratase catabolic TdcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044561">
        <property type="entry name" value="ACT_ThrD-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050147">
        <property type="entry name" value="Ser/Thr_Dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078:SF19">
        <property type="entry name" value="ACT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078">
        <property type="entry name" value="THREONINE DEHYDRATASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="9">
        <location>
            <begin position="358"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00042605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="JAV67779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0804225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="445" mass="48429" checksum="7028279C139C116C" modified="2017-08-30" version="1">MEELTFRHSSEEQDSDDEIIQDPFCDPERPLKITFEDITSAAFKIKSGVIRTPCDRSQLSDTTGIDMFFKKDYLQYTGSFKDRGARYALLMLDQAKKKAGVISASLGNHALALCYHGFKLGIPVTVVMPVVAPIMKISQCRKFNANVIVKGKDMGEAKKVALKLAKKQGYTYINGYDHPDIMAGQGTIGLEIVEQVENIDAVVIPIGGGGLIAGAALAIKTLYPNIKIIGVESERCASFSKAVEAGKPVYVNIESTLSDGLAVPQVGYNAFETARSLIDKLVVVREEWIAIAILRLIEYEKCVVEGAGAVGLAAILAGQLNELRGKRVVLNLCGGNIDTTILGRCLERGLAADGRLVKIVATVSDRPGGIAEFCKLLAGFGVSIKDILHERAWVATDVFSVEITVVCETRDSEHTSQLRELLKNNYKRVEFVDFPHVYPGISGND</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1L3Y2</accession>
    <name>A0A1Y1L3Y2_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mid1-interacting protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PPYR_05686</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SPOT14 family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01069066">
        <property type="protein sequence ID" value="JAV66665.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000003">
        <property type="protein sequence ID" value="KAB0801332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1L3Y2"/>
    <dbReference type="FunCoup" id="A0A1Y1L3Y2">
        <property type="interactions" value="312"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1L3Y2"/>
    <dbReference type="OrthoDB" id="5951908at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046890">
        <property type="term" value="P:regulation of lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053719">
        <property type="entry name" value="Lipogen_MT_Stabilize_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009786">
        <property type="entry name" value="Spot_14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14315:SF17">
        <property type="entry name" value="MIP21584P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14315">
        <property type="entry name" value="SPOT14 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
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    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="139"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="139"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="156"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00009488"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="JAV66665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0801332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="218" mass="24636" checksum="D0683F0B26071972" modified="2017-08-30" version="1">MNNYSDNISNNVEESRCYFRRLGLHDNSEFSNQSIITAISELVKSITTMDETILVPCRLMDLKVGDEQDRIAPKKHNLKNKNDVQEILSSTDLFDVYNMLNSIKADLLWGQNMEHDTSSKTETPNTQLTVCKGHIRRPSTVSVTSTNSSASIISDSESETGNENDSGIEEPPQVQNQTALLAQNFRRHLKGLTRCIRQMSDATQYLTLRYQHDIGNPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1L605</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">PPYR_01892</name>
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    <organism evidence="2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
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            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01067797">
        <property type="protein sequence ID" value="JAV67425.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KAB0804922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR11257:SF12">
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        <property type="entry name" value="Chemosensory protein Csp2"/>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036312532" evidence="1">
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            <begin position="19"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="JAV67425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0804922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="135" mass="15702" checksum="F81ACAC6FF563F9B" modified="2017-08-30" version="1">MKTLLVVLFFAIIAAAWARPKELYTDEFDNIDEDAILASKRLVDNYIHCAKTGKKCSPDGQKFRDLIPQALKTRCEKCTETQKTKIKKILKWIVENRPNDFLEIEALFDKTHEYRTLYADELKKENIILPALKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1L9B1</accession>
    <name>A0A1Y1L9B1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Mitochondrial fission 1 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PPYR_08396</name>
        <name evidence="14" type="ORF">PPYR_10434</name>
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    <organism evidence="13">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
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        <dbReference type="NCBI Taxonomy" id="7054"/>
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            <taxon>Metazoa</taxon>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
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            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
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            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
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                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Involved in the fragmentation of the mitochondrial network and its perinuclear clustering.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The C-terminus is required for mitochondrial localization, while the N-terminus is necessary for mitochondrial fission.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the FIS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01063919">
        <property type="protein sequence ID" value="JAV68910.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="interactions" value="1106"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1L9B1"/>
    <dbReference type="OrthoDB" id="421154at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043653">
        <property type="term" value="P:mitochondrial fragmentation involved in apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000147">
        <property type="entry name" value="Mitochondrial fission 1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016543">
        <property type="entry name" value="Fis1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033745">
        <property type="entry name" value="Fis1_cytosol"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028061">
        <property type="entry name" value="Fis1_TPR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028058">
        <property type="entry name" value="Fis1_TPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13247:SF0">
        <property type="entry name" value="MITOCHONDRIAL FISSION 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13247">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 11 TPR REPEAT PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14853">
        <property type="entry name" value="Fis1_TPR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14852">
        <property type="entry name" value="Fis1_TPR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TPR_repeat_11_Fis1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="9 11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 11" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="10" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="122"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008937"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR008835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="JAV68910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAB0796373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAB0797402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="150" mass="16896" checksum="598FEE17EA210601" modified="2017-08-30" version="1">MDDVLTETVPAEELKKFEKAYHEQLYKQDVTPKAQFEYAWCLVRSKYPADIKKGIFLLQELFRTHEEGQRDYLYYLAIGNARIKQYTEALKYVRSFLNIEPGNSQVIALETTIKAKMDKEGLMGMAVAGGVVLAIGAAVGLGISILNKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1L9F9</accession>
    <name>A0A1Y1L9F9_PHOPY</name>
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        <recommendedName>
            <fullName evidence="4">Vacuolar protein sorting-associated protein 53 homolog</fullName>
        </recommendedName>
    </protein>
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        <name evidence="12" type="ORF">PPYR_03732</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VPS53 family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01061827">
        <property type="protein sequence ID" value="JAV70302.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KAB0791932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="FunCoup" id="A0A1Y1L9F9">
        <property type="interactions" value="1917"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1L9F9"/>
    <dbReference type="OrthoDB" id="10261632at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
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        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Vacuolar protein sorting-associated protein 53, C-terminus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039766">
        <property type="entry name" value="Vps53"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031745">
        <property type="entry name" value="Vps53_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038260">
        <property type="entry name" value="Vps53_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007234">
        <property type="entry name" value="Vps53_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12820:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 53 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12820">
        <property type="entry name" value="VACUOLAR SORTING PROTEIN 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16854">
        <property type="entry name" value="VPS53_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Vps53_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="7" id="KW-0472">Membrane</keyword>
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        <location>
            <begin position="44"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="Vps53 C-terminal" evidence="10">
        <location>
            <begin position="683"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="61"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="JAV70302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAB0791932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="816" mass="92869" checksum="173CE78B6B682E6F" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LF98</accession>
    <name>A0A1Y1LF98_PHOPY</name>
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        <recommendedName>
            <fullName evidence="3">inorganic diphosphatase</fullName>
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        </recommendedName>
    </protein>
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        <name evidence="8" type="ORF">PPYR_06428</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
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            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.1" evidence="3"/>
    <dbReference type="EMBL" id="GEZM01057452">
        <property type="protein sequence ID" value="JAV72329.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000004">
        <property type="protein sequence ID" value="KAB0800689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1LF98"/>
    <dbReference type="InParanoid" id="A0A1Y1LF98"/>
    <dbReference type="OrthoDB" id="1608002at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006796">
        <property type="term" value="P:phosphate-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.80.10">
        <property type="entry name" value="Inorganic pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR036649">
        <property type="entry name" value="Pyrophosphatase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10286">
        <property type="entry name" value="INORGANIC PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00719">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50324">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="JAV72329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0800689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="197" mass="22506" checksum="D7CCE82BE14B8724" modified="2017-08-30" version="1">MIYHVLKTFLLGNVVRKSRTGKAFLNSFTQATFNRQSQVAMSYGIVERGSPFSQDYRVYITDNNVPISPLHDIPLFSDQEKNLYNMVVEVPRWTNAKMEITMKEVLNPIKQDIKKGKPRFVSNCFPHHGYIWNYGALPQTWENPDHLDDGTGAKGDNDPIDVIEIGYRIAKRGEILQVKIIGTIALIDEGKFITLDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LHV8</accession>
    <name>A0A1Y1LHV8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Voltage-dependent anion-selective channel protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PPYR_13109</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic mitochondrial porin family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01058079">
        <property type="protein sequence ID" value="JAV71920.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1LHV8"/>
    <dbReference type="FunCoup" id="A0A1Y1LHV8">
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    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1LHV8"/>
    <dbReference type="OrthoDB" id="7827681at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046930">
        <property type="term" value="C:pore complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015288">
        <property type="term" value="F:porin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008308">
        <property type="term" value="F:voltage-gated monoatomic anion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07306">
        <property type="entry name" value="Porin3_VDAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.10:FF:000001">
        <property type="entry name" value="Voltage-dependent anion-selective channel protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="entry name" value="Porin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001925">
        <property type="entry name" value="Porin_Euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027246">
        <property type="entry name" value="Porin_Euk/Tom40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11743:SF70">
        <property type="entry name" value="GH26960P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11743">
        <property type="entry name" value="VOLTAGE-DEPENDENT ANION-SELECTIVE CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01459">
        <property type="entry name" value="Porin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00185">
        <property type="entry name" value="EUKARYTPORIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00558">
        <property type="entry name" value="EUKARYOTIC_PORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="8" id="KW-0626">Porin</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="JAV71920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAB0793489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="282" mass="30517" checksum="20194072536F94C2" modified="2017-08-30" version="1">MSPPTYSDLGKNARDVFGKGYHFGLIKVDCKTKTNSGVEFNTGGVSNQESGKVFGSLETKYKVKEYGLTFSEKWNTDNTLATEVTVQDQLMKGLKLSADCTFAPQTGNKTGRVKSAFQHDLCSLNCDVDLDMAGPLIQASAVVGHQGWLAGYQTAFDTQRSRLTKNNFALGFSTGDFILHTNVDDGQEFGGSIYQKLSPKLETGIQLAWSAGSNNTRFGIGAKYELDADACIRAKVNNASQIGLGYQQRLRDGITITLSTLIDGKNFNNGGHKIGLALELEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LQ85</accession>
    <name>A0A1Y1LQ85_PHOPY</name>
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        <recommendedName>
            <fullName evidence="5">Transcription factor 25</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_08605</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01049848">
        <property type="protein sequence ID" value="JAV75809.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1LQ85"/>
    <dbReference type="FunCoup" id="A0A1Y1LQ85">
        <property type="interactions" value="2394"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1LQ85"/>
    <dbReference type="OrthoDB" id="205993at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990112">
        <property type="term" value="C:RQC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006994">
        <property type="entry name" value="TCF25/Rqc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22684">
        <property type="entry name" value="NULP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22684:SF0">
        <property type="entry name" value="RIBOSOME QUALITY CONTROL COMPLEX SUBUNIT TCF25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04910">
        <property type="entry name" value="Tcf25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="633"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="636"/>
            <end position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="JAV75809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0797612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="657" mass="74720" checksum="3467C7B5670C3BBA" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LX67</accession>
    <name>A0A1Y1LX67_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Carboxypeptidase</fullName>
            <ecNumber evidence="7">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_11396</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="7"/>
    <dbReference type="EMBL" id="GEZM01050301">
        <property type="protein sequence ID" value="JAV75627.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0794557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1LX67"/>
    <dbReference type="FunCoup" id="A0A1Y1LX67">
        <property type="interactions" value="62"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1LX67"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000096">
        <property type="entry name" value="Carboxypeptidase vitellogenic-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033124">
        <property type="entry name" value="Ser_caboxypep_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF472">
        <property type="entry name" value="SERINE CARBOXYPEPTIDASE CPVL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00560">
        <property type="entry name" value="CARBOXYPEPT_SER_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033827395" description="Carboxypeptidase" evidence="7">
        <location>
            <begin position="21"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="JAV75627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0794557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="468" mass="53329" checksum="D5318E93B13D1499" modified="2017-08-30" version="1">MCKSLCVTLLLLTCILQTHSITNMYPKIESELYRGGSGEPLILTPLIKQGRIKEAQHAASVSLNDVKQVKSYAAYLTVNEQFNSNLFFWFFPSQLNYANDPVILWLQGGPGATSLIGLFTENGPFIVTPQQTLTPRKYSWTYGHSVIYIDNPVGTGYSFTDDGGYSQNETVIGENVYRALLQFFQLFPEIQRNPFFITGESYAGKYVPAVSYTIHKKNPTATQKINLQGLSIGNGLSDPINQLRYGDYLYQIGLVDTNVRKHMLNMEIKGIKYIQHEDYANAFRVFDDLLNGDLNNHTSLFKNVTGFDNYFNYLFAENDDSSYMGKFIQRSDIRSAIHVGGAKFNGQNELVEQNLITDIMRSVRDWVSELLSHYRVLIYNGQLDIVVAYPLTVNYLKNLNYSAAREYKTAARYQWRMGKEIAGYVKVAGNLTEIMVRNAGHMVPKDQPKWALDLITRFTRNKPYHNEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LY92</accession>
    <name>A0A1Y1LY92_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">cardiolipin synthase (CMP-forming)</fullName>
            <ecNumber evidence="13">2.7.8.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PPYR_00803</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">1611_PpyrPB1</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">1611_PpyrPB1</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a CDP-1,2-diacyl-sn-glycerol + a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) = a cardiolipin + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32931"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:62237"/>
            <dbReference type="ChEBI" id="CHEBI:64716"/>
            <dbReference type="EC" id="2.7.8.41"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.41" evidence="13"/>
    <dbReference type="EMBL" id="GEZM01045582">
        <property type="protein sequence ID" value="JAV77738.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1LY92"/>
    <dbReference type="FunCoup" id="A0A1Y1LY92">
        <property type="interactions" value="1205"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1LY92"/>
    <dbReference type="OrthoDB" id="10020554at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043337">
        <property type="term" value="F:cardiolipin synthase (CMP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1760:FF:000005">
        <property type="entry name" value="Cardiolipin synthase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050324">
        <property type="entry name" value="CDP-alcohol_PTase-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269:SF60">
        <property type="entry name" value="CARDIOLIPIN SYNTHASE (CMP-FORMING)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="216"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00039001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="JAV77738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAB0803833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="323" mass="36588" checksum="788947A547ADBC6C" modified="2017-08-30" version="1">MNSLKSFSILHRFFETRLRGCCDMVFISYNPKVNFTYFHMNKYLQKHQRFKFQTLCTVHDKGRPPFDSKNVKKEIQSYIRQKQIKLKATEQRIKVCGETLRKDFVDTKNKVKEKVEEVIERENIYTIPNFLCVSRILLSPYLGLLIVQAEFHFALALLGVAAVTDLLDGWIARTWASQSSIMGSFLDPMADKVLIATLFLSLTYADLIPVSLTGLILLRDVLLVAAALALRYKSLSSPRTMGKLFDISHATVQIKPTFISKINTGVQLALVGSTLAAPVFHYVGHPLLQSLWYITAATTIAGGLSYILSKNTYKIIKKKNNKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LZU7</accession>
    <name>A0A1Y1LZU7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Endoplasmic reticulum vesicle transporter C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PPYR_12313</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum-Golgi intermediate compartment membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERGIC family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01044408">
        <property type="protein sequence ID" value="JAV78248.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0795474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1LZU7"/>
    <dbReference type="FunCoup" id="A0A1Y1LZU7">
        <property type="interactions" value="1204"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1LZU7"/>
    <dbReference type="OrthoDB" id="5541786at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033116">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045888">
        <property type="entry name" value="Erv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012936">
        <property type="entry name" value="Erv_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039542">
        <property type="entry name" value="Erv_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984">
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="COPIIcoated_ERV"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="321"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter N-terminal" evidence="8">
        <location>
            <begin position="19"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter C-terminal" evidence="7">
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            <begin position="172"/>
            <end position="339"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004457"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00005648"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF07970"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF13850"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="JAV78248.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAB0795474.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="374" mass="42766" checksum="91AAFB87F6173875" modified="2017-08-30" version="1">MEAEKVSLLRYRGSKLQHVKKLDLFPKVDEKCKEQTSFGGTLSIVSFALIFWLAYSEINYYLNSKFVFKFSPDIDFDAKLKLNVDITVAMPCSNLGADILDSTNQNTFKFGSLEEEDTWYELAPNQQKYFENRQHFNTYLREEYHSVQEFLWRSSHTSIFTNMPARNNKPLKPHDACRIYGSLILNKVAGNFHITAGKSLNLPRGHIHISAFMSDSDYNFTHRINKLSFGDPSPGIIHPLEGDEQVANSSSVLYQYFIDIVPTSVNTYLSTVETYQYSVKELSRPIDHGKGSHGMPGIFFKYDVSALKVTVRQERDNFGMFLARLCSIIAGIYICSSFINSFVLSLLRMCSKLTRSKELKQHVHIPDVVPVQTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1M016</accession>
    <name>A0A1Y1M016_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Queuine tRNA-ribosyltransferase catalytic subunit 1</fullName>
            <ecNumber evidence="6">2.4.2.64</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Guanine insertion enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">tRNA-guanine transglycosylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_08545</name>
        <name evidence="10" type="ORF">PPYR_09560</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming queuine, allowing a nucleophilic attack on the C1' of the ribose to form the product.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 6">
            <text>guanosine(34) in tRNA + queuine = queuosine(34) in tRNA + guanine</text>
            <dbReference type="Rhea" id="RHEA:16633"/>
            <dbReference type="Rhea" id="RHEA-COMP:10341"/>
            <dbReference type="Rhea" id="RHEA-COMP:18571"/>
            <dbReference type="ChEBI" id="CHEBI:16235"/>
            <dbReference type="ChEBI" id="CHEBI:17433"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:194431"/>
            <dbReference type="EC" id="2.4.2.64"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterodimer of a catalytic subunit and an accessory subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the queuine tRNA-ribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.64" evidence="6"/>
    <dbReference type="EMBL" id="GEZM01048418">
        <property type="protein sequence ID" value="JAV76577.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01048417">
        <property type="protein sequence ID" value="JAV76582.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1M016"/>
    <dbReference type="FunCoup" id="A0A1Y1M016">
        <property type="interactions" value="1038"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1M016"/>
    <dbReference type="OrthoDB" id="10249838at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008479">
        <property type="term" value="F:tRNA-guanosine(34) queuine transglycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.105">
        <property type="entry name" value="Queuine tRNA-ribosyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00168">
        <property type="entry name" value="Q_tRNA_Tgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004803">
        <property type="entry name" value="TGT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036511">
        <property type="entry name" value="TGT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002616">
        <property type="entry name" value="tRNA_ribo_trans-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00430">
        <property type="entry name" value="Q_tRNA_tgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00449">
        <property type="entry name" value="tgt_general"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43530">
        <property type="entry name" value="QUEUINE TRNA-RIBOSYLTRANSFERASE CATALYTIC SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43530:SF1">
        <property type="entry name" value="QUEUINE TRNA-RIBOSYLTRANSFERASE CATALYTIC SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01702">
        <property type="entry name" value="TGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51713">
        <property type="entry name" value="tRNA-guanine transglycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="5 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA-guanine(15) transglycosylase-like" evidence="7">
        <location>
            <begin position="18"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="RNA binding" evidence="6">
        <location>
            <begin position="254"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="RNA binding; important for wobble base 34 recognition" evidence="6">
        <location>
            <begin position="278"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="273"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="97"/>
            <end position="101"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="JAV76577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0797552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0798567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="395" mass="44399" checksum="103473683478BE2F" modified="2017-08-30" version="1">MSSRHPLVFHVLAECKISKARVSKMILPHGEVDTPVFMPVGTQGTLKGLLTEQLDNLGVQIMLANTYHLGIKPGVEILKKAGGLHKFMNWNCALLTDSGGFQMVSLLKLAVITEKGVQFRSLNASKSEIVLTPEHSIEIQNVIGADIIMQLDDVVKTTSSDDKRIEEAMYRTTRWLDRCMQSHKRVEDQNIFPIVQGTLNTKLRSLSAKAHMKRDVRGFAIGGLSGGESKDEFWKMVNLSTDILPKNKPRYLMGVGFAIDLVVCTALGVDMYDCVFPTRTARFGCALVMTGQLNLKQKMYKTDLTPIDKDCDCSTCKTYTRSYLHHIATIHTVSCHLLTVHNVAFQLRLMRNIRESIKENKFVEFVQSFMVDLHPNKDYPNWVIDALQAVGIQLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1M0Y8</accession>
    <name>A0A1Y1M0Y8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PPYR_09382</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">1611_PpyrPB1</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">1611_PpyrPB1</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Microsome membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01042998">
        <property type="protein sequence ID" value="JAV79399.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1M0Y8"/>
    <dbReference type="InParanoid" id="A0A1Y1M0Y8"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20628">
        <property type="entry name" value="CYP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000182">
        <property type="entry name" value="Cytochrome P450 3A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
        <property type="entry name" value="Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291:SF105">
        <property type="entry name" value="CYTOCHROME P450 4P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="11 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="7 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0492">Microsome</keyword>
    <keyword evidence="12 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="10 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="440"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="JAV79399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAB0798389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="494" mass="57477" checksum="19FED7C5F87CB517" modified="2017-08-30" version="1">MIWWFFLFILGFVFLHRKWRYRYLMAIPGPPSLPLIGNTLPMLASPERAWCLLQEYNKVYYPIYRLSNGLLDSVHISAPDDIELILSSKTHLRKSIIYDLLQSWLGKGLLTSDGDRWYHRRKLLTPTFHFNIIQQFFTVFATHSEALVQQLDKECDKSCTNIIPLITKFTLFTICETAMGTKLDEKKEGNRDYVSATFEMGQLFINRIRRPWLAYNVIFNMTEKKKEQTSLLNILHSFSKSVIEDRKQHFKEVVQNEDEHDDQFHQKKRVAMLDLLLSVRNSGAQISDEEIREEVDTFIFEGHDTTSAAISYALMLIANHSNVQEKIVEEINHIVDGSSRPLNFADIQQLSYLERVVKESLRMYPSVPVIGRRVDFDVVTSTSHVIPKDTIVSVHIFGLHHNPKFYPDPEKFDPDRFLPQNMKGRHPFSYIPFSAGPRNCIGQRFAMVEMKTAIASVVRNFRLLPIDKPSDLQFMAHLILKANKGVHIKFEKRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1ME64</accession>
    <name>A0A1Y1ME64_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_13347</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01038525">
        <property type="protein sequence ID" value="JAV81617.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1ME64"/>
    <dbReference type="InParanoid" id="A0A1Y1ME64"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="JAV81617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0793727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="119" mass="13842" checksum="AE711FAF6FA7A523" modified="2017-08-30" version="1">MMTQNRKRGRNLNEDEVEFMPLSKRINNLHINGNIFFESHNAILPHSNLAVSDWGQGPPCYNGEVSYSSIQTPTESLQNVNFDTSEYNPVLSAAENPHYFYKNKLLFEMHIERMQRNSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1MLZ8</accession>
    <name>A0A1Y1MLZ8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Vacuolar protein sorting-associated protein 52 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PPYR_09124</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS52 family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01033531">
        <property type="protein sequence ID" value="JAV84227.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1MLZ8"/>
    <dbReference type="FunCoup" id="A0A1Y1MLZ8">
        <property type="interactions" value="2049"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1MLZ8"/>
    <dbReference type="OrthoDB" id="19482at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007041">
        <property type="term" value="P:lysosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007258">
        <property type="entry name" value="Vps52"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048361">
        <property type="entry name" value="Vps52_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048319">
        <property type="entry name" value="Vps52_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14190">
        <property type="entry name" value="SUPPRESSOR OF ACTIN MUTATIONS 2/VACUOLAR PROTEIN SORTING 52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14190:SF7">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 52 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Vps52_C"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
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    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vps52 coiled-coil" evidence="8">
        <location>
            <begin position="57"/>
            <end position="229"/>
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    </feature>
    <feature type="domain" description="Vps52 C-terminal" evidence="9">
        <location>
            <begin position="246"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF20655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="JAV84227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0798131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="669" mass="78249" checksum="261D7206AEA50AD2" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
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    <name>A0A1Y1MWL1_PHOPY</name>
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            <fullName evidence="1">CRAL-TRIO domain-containing protein</fullName>
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        <name evidence="3" type="ORF">PPYR_11020</name>
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    <organism evidence="2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
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            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01018847">
        <property type="protein sequence ID" value="JAV90013.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KAB0796959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="1434354at2759"/>
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    </dbReference>
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    </dbReference>
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        <property type="term" value="F:phosphatidylinositol bisphosphate binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
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    </dbReference>
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        <property type="entry name" value="N-terminal domain of phosphatidylinositol transfer protein sec14p"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="CRAL_TRIO"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="102"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="JAV90013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0796959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="319" mass="36522" checksum="9DF937F1D4E11E8E" modified="2017-08-30" version="1">MGLGGKDVTSEDYVCTLPESLRKVALEELREDDSIRQQSLDQMREWINKNSAIKTCRKDAPFLLRFLRTKKFSVPLACEMLERYLMIRQLYPQWFRNLDSDDNDLAQLVDSGYIVPLPQKHNGKTVIFTCAEKFDPYKFTAASMIRIHSLVAEVLMDDEENQVNGYVYVNDIGGFQLGHISLWSLKDIRNVIRCVQNSSPMRHKESHFVNVSPNAAKLVEFGLTVLSEKLKNRTFIHKSVTDLHERISPSILPKEYGGVVPLADMINAFKSKIQDCRKKILALDDLHIEIDERNCALIDEMNEELGVGIEGSFKKLQVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1N4G3</accession>
    <name>A0A1Y1N4G3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcription initiation factor IIE subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PPYR_01982</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Tetramer of two alpha and two beta chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TFIIE beta subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01013039">
        <property type="protein sequence ID" value="JAV92801.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0805012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1N4G3"/>
    <dbReference type="FunCoup" id="A0A1Y1N4G3">
        <property type="interactions" value="1843"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1N4G3"/>
    <dbReference type="OrthoDB" id="5323195at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005673">
        <property type="term" value="C:transcription factor TFIIE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001097">
        <property type="term" value="F:TFIIH-class transcription factor complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07977">
        <property type="entry name" value="TFIIE_beta_winged_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000177">
        <property type="entry name" value="Transcription initiation factor IIE subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040501">
        <property type="entry name" value="TFA2_Winged_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016656">
        <property type="entry name" value="TFIIE-bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003166">
        <property type="entry name" value="TFIIE_bsu_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12716:SF8">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12716">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIE, BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18121">
        <property type="entry name" value="TFA2_Winged_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02186">
        <property type="entry name" value="TFIIE_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016398">
        <property type="entry name" value="TFIIE-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51351">
        <property type="entry name" value="TFIIE_BETA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TFIIE beta" evidence="9">
        <location>
            <begin position="54"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="236"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="22"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="246"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="262"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR016398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="JAV92801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0805012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="293" mass="33641" checksum="4A1C5FDD57EC9D58" modified="2017-08-30" version="1">MDPALLKERELFKKRALTTPSVEKRKAEPIRDDKKKPKTSSAPAPKLDINSYKTATGSSQYRFGVLAKIVKHMRTRHQEGDQHPLTLEEILDETNQLDVGNKVKIWLQTEALQSNPKVEVTMDGKFIFKAMYKLKDRKSLLKLLKQQDLKGLGGILLDDVQESLPHAEKALKTLQNQNEIIFVSRPTDKKKILFYNDRTASLPVDEEFQKLWRSVAVDAMDDAKIDEYLEKQGIRSMQDHGLKKPMAPKRKKAAQRKKQFKKPRDNEHLADVLENYEDTTLTQKGQFSSKTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1N4J5</accession>
    <name>A0A1Y1N4J5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Membrane magnesium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PPYR_01810</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. May be involved in Mg(2+) transport.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the ER membrane protein complex (EMC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Golgi apparatus membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Early endosome membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the membrane magnesium transporter (TC 1.A.67) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01013132">
        <property type="protein sequence ID" value="JAV92724.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01013131">
        <property type="protein sequence ID" value="JAV92726.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01013130">
        <property type="protein sequence ID" value="JAV92729.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01013129">
        <property type="protein sequence ID" value="JAV92730.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1N4J5"/>
    <dbReference type="FunCoup" id="A0A1Y1N4J5">
        <property type="interactions" value="1413"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1N4J5"/>
    <dbReference type="OrthoDB" id="44756at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022890">
        <property type="term" value="F:inorganic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018937">
        <property type="entry name" value="MMgT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21181">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21181:SF7">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10270">
        <property type="entry name" value="MMgT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011907535" description="Membrane magnesium transporter" evidence="9">
        <location>
            <begin position="27"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="JAV92729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0804840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="118" mass="13625" checksum="8563FE5900F0623A" modified="2017-08-30" version="1">MPPSIFHRLILTAGFLSLFHAAYSAAQHRSYLRLNELEFTSLPLDILIQGVTSLFVVMYGVLYIAGDFKEIKASAELENKTWETYRNIPSFYTFNHRGKAFSPQYVQMNSKLQIEEIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1N7Z0</accession>
    <name>A0A1Y1N7Z0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PPYR_01055</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01010547">
        <property type="protein sequence ID" value="JAV94000.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01010546">
        <property type="protein sequence ID" value="JAV94001.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1N7Z0"/>
    <dbReference type="FunCoup" id="A0A1Y1N7Z0">
        <property type="interactions" value="1489"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1N7Z0"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03753">
        <property type="entry name" value="proteasome_alpha_type_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000019">
        <property type="entry name" value="Proteasome subunit alpha type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033812">
        <property type="entry name" value="Proteasome_alpha_type_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003075">
        <property type="entry name" value="PRK03996.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
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    </dbReference>
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        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 6 7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="9">
        <location>
            <begin position="8"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="253"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="JAV94001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0804085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="265" mass="28913" checksum="6DEEDB9116DD91CB" modified="2017-08-30" version="1">MFLTRSEYDRGVNTFSPEGRLFQVEYAIEAIKLGSTAIGICTREGVVLAVEKRITSPLMEPTTIEKIVEVDKHIGCVVSGLMADSRTMIDRARVECQNHWFVYNERMTVESCAQAVSNLAIQFGDSDDDGAAMSRPFGVAILFAGIDEKGPQLYHMDPSGTFVQFDAKAIGSGSEGAQQSLQEVYHRSMTLAEATTASLTILKQVMEEKLNSTNVEVMTMTPKGLYHMFTKEDVEEALKNVAPLEHSRGDTPATGSGVQAKTSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1NAY2</accession>
    <name>A0A1Y1NAY2_PHOPY</name>
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        <recommendedName>
            <fullName evidence="6">28S ribosomal protein S27, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_07529</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GEZM01007665">
        <property type="protein sequence ID" value="JAV95013.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KAB0799649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    </dbReference>
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        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS27"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="358"/>
            <end position="400"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="JAV95013.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAB0799649.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="422" mass="49831" checksum="083242491B9F9947" modified="2017-08-30" version="1">MFKVFKQTLKVQVVNVLKVRTFLSHAYYCNEVWDQRFQDSILEKVNLDELYNELEQQYQRTRNINAVDVDVFAHSVRDESYIEELLDLLYKLRMSADTCNTLNSTSHAVIRDFTNFAKTDQLLQTLDDRLNYGVFLDHYTANLLLDTFWKSKDYRSGARVASQLMLQEDFNHPISSSLSLLHCFKFLQNPSEWPQPPKPEEPEEEVRVRVKYVRNPHDDEHFDLKDPHRIVGKTLIEIARPFQDSLNRSFYLLGVMLYKPDKAVGVIDKFVKDNVVVYKNVLSVVPEEALGTFSVDKLQMESVELGILEDNVRTAVNKMSEKDIAVQCEAYVRWEKERKEALENQHKRLLAMQRLSNIEKLQKDMKEKEMLLWFFENEEKIELEIEAKKKEIEASKMLRRGPKMKEDEEEYIPPEVYKRKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1NB73</accession>
    <name>A0A1Y1NB73_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">UNC93-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PPYR_10795</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the unc-93 family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01007502">
        <property type="protein sequence ID" value="JAV95141.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1NB73"/>
    <dbReference type="FunCoup" id="A0A1Y1NB73">
        <property type="interactions" value="40"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1NB73"/>
    <dbReference type="OrthoDB" id="78663at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:striated muscle dense body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015459">
        <property type="term" value="F:potassium channel regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006937">
        <property type="term" value="P:regulation of muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043266">
        <property type="term" value="P:regulation of potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17406">
        <property type="entry name" value="MFS_unc93A_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000290">
        <property type="entry name" value="Unc-93 homolog A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010291">
        <property type="entry name" value="Ion_channel_UNC-93"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051951">
        <property type="entry name" value="UNC-93_regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19444:SF13">
        <property type="entry name" value="PROTEIN UNC-93 HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19444">
        <property type="entry name" value="UNC-93 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05978">
        <property type="entry name" value="UNC-93"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="125"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="214"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="251"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="386"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="418"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="449"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="538"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="569"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="569"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="585"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="JAV95141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0796734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="604" mass="66757" checksum="A816033885DCC32B" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1NCY4</accession>
    <name>A0A1Y1NCY4_PHOPY</name>
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        <recommendedName>
            <fullName evidence="6">4Fe-4S ferredoxin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_13042</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
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        <property type="protein sequence ID" value="JAV95772.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000009">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="OrthoDB" id="7323052at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="FU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006212">
        <property type="entry name" value="Furin_repeat"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036029949" description="4Fe-4S ferredoxin-type domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="JAV95772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0793422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="358" mass="40809" checksum="072FDD7C5B08F9E5" modified="2017-08-30" version="1">MCIFGDVPFSFYLLLLIVRLGECQTSNLTGCKQEPLCLKCGSAGCIKCPHLIVYSTRKCVDSCPSGYQIQWSKSLDYMGQTCTQTSTSIGLSPASLSILVGVLCGIIFSVFIVTFAVFYLRRKRSYLHYVIETSSDVDDSPEKRDFIKQLEHFRPYARTFLEMLNDTRRQVRELHSEADNTAASAYKPVIRDLAKILLLLNRPVEVLAVPDDWERLHRWAEKLLRRHGQMGDVSQSQVNQLIKFLQTPSISKDPEEYSRASTTLSTFKPDQNYGSSPSLTGQPLKNFSDSADSGNFTSPLNPQWQFNYPVMSNKHFNSSQFIPSQWKSSREYLNNPYLLEDDFLQLGFRPQDEITTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1NGN6</accession>
    <name>A0A1Y1NGN6_PHOPY</name>
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        <recommendedName>
            <fullName evidence="7">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_05954</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01002926">
        <property type="protein sequence ID" value="JAV97064.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000004">
        <property type="protein sequence ID" value="KAB0800214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1NGN6"/>
    <dbReference type="FunCoup" id="A0A1Y1NGN6">
        <property type="interactions" value="130"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1NGN6"/>
    <dbReference type="OrthoDB" id="7458135at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14698">
        <property type="entry name" value="bZIP_CNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.880.10:FF:000004">
        <property type="entry name" value="Nuclear factor, erythroid 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.880.10">
        <property type="entry name" value="Transcription factor, Skn-1-like, DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004826">
        <property type="entry name" value="bZIP_Maf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047167">
        <property type="entry name" value="NFE2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008917">
        <property type="entry name" value="TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24411">
        <property type="entry name" value="NUCLEAR FACTOR ERYTHROID 2-RELATED FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24411:SF55">
        <property type="entry name" value="SEGMENTATION PROTEIN CAP'N'COLLAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03131">
        <property type="entry name" value="bZIP_Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47454">
        <property type="entry name" value="A DNA-binding domain in eukaryotic transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0010">Activator</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="7">
        <location>
            <begin position="818"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="579"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="751"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="589"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="760"/>
            <end position="779"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="JAV97064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0800214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="936" mass="104393" checksum="1DF42C94580B03E1" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N3ZY72</accession>
    <name>A0A5N3ZY72_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF4806 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_15697</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01002073">
        <property type="protein sequence ID" value="KAB0790012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N3ZY72"/>
    <dbReference type="InParanoid" id="A0A5N3ZY72"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34153:SF2">
        <property type="entry name" value="SI:CH211-262H13.3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34153">
        <property type="entry name" value="SI:CH211-262H13.3-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0790012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="383" mass="43571" checksum="37647DDFDD880C00" modified="2020-02-26" version="1">MTCKDNMATWSVVKFPSDNSVEAVPTSWLNGNRCVWPSYPLNSQKLLDAVEKQSSPGCDWQTYDIIPFKNNVFDDFTVAKKKAEKALATSDLESDSQAFEEKNKTSTKRKIKLKKEFSFSSVEEESLDFVPPELNFNELPSRKPDINNGFEHKGHRPSKSTKKVNIIQDIEVTPYRIATTRNCNNNSAVTSTETPPSRNTGRNISNSDLYDLLTRILRKQELLHVVVADIRQGLDNIEASLLKVPVESEKENSILAQFELPLNSKESLAHFEEFFVREVSLLGGRHMYEFIYRCGKMLITNGFASTYSYCGKRNKEAFKELHLNKLMIHSLDATLVTLLEKSAESMKKRSDEIKNRISKNVPLNRSLLEESIERNAASSWTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A069</accession>
    <name>A0A5N4A069_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4371 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_14840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000868">
        <property type="protein sequence ID" value="KAB0790712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A069"/>
    <dbReference type="InParanoid" id="A0A5N4A069"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025398">
        <property type="entry name" value="DUF4371"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37162:SF1">
        <property type="entry name" value="BED-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37162">
        <property type="entry name" value="HAT FAMILY DIMERISATION DOMAINCONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14291">
        <property type="entry name" value="DUF4371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4371" evidence="2">
        <location>
            <begin position="152"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0790712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="425" mass="48115" checksum="27A9B092E60DF344" modified="2020-02-26" version="1" fragment="single">MSSGSDSNRVDSDTDDSSPSASTSRKRPKLAYKQKYKKDWEKQMPWLQESQNGASFACKCDIKITHGKGDLVKHEYTSKHTKSCVSTVGQKTITSMFAEKTKEMTTEMRAKEAEIRIAGFVAEHNLPFKIMEHLPDLMRAVCSDSAIAKKIKCGPTKIKSIITNVTGETHRQNLIALMNSNKFSLIADESTDRSCTKNLCLVARINCNNNNVKDYFLALIPIHDATGAALFEHIIQFFNKYGIDFKQNCIGFASDGANNMMGGQNSVVSRIKELIPGIFVMKCICHSFHLCASYACEKLPEEVEKFARYVYNYFSNSPKRTEELKEFQQFANVSPVKMLHPSSTRWLSLESVVTRLLTQYGALTLYFTDKASSKKDQAAFSILHLLQQPETKLYLEFLAYALPFFNKLNTLMQSEQPQIHTIYKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A086</accession>
    <name>A0A5N4A086_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_01501</name>
        <name evidence="2" type="ORF">PPYR_15703</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000816">
        <property type="protein sequence ID" value="KAB0790730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A086"/>
    <dbReference type="InParanoid" id="A0A5N4A086"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0790730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0804531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="475" mass="54590" checksum="0A68EFFF72174B3A" modified="2020-02-26" version="1">MEYLQQKKAQQISLDVSISKPTTSASIASASTETESSQSDIFFFEPDKELLEVLSFPDESSNATKRILEDRTEDYVNKRSSTDSPKNKSLEQLFRSTPEGQIILANRAKLNNDLRSKIAKIVVRSLLDCSEGQSRIEINTLQFVRAAKEIAELFPGESEHTYYIPYSSSKKGLRRQPARGKLWSRYINLKAALRLVNAANADVEQENVPSTSNTSYDEEEKIAFLKVAVEPFDKILSYWEDTYLIRQRKCKSYELEDIYKEFPCLSLHYGITLLESDFNHSNEEKIDIIYSEWPKIAQAIIIEAKERQLILKEDVIKDVNSKALLVLPYLFSPVTIRNSKKRGIWRPSRSEVQESFLFNVQEFAEASSIVERRKQKLHSYDLPLQPFGVIVGDDCQDVRAFYVFINGNKYTCESGIRCLELLYKSFHALNLEYPSESKHVWYFVQELVFKTSVSNKVGSTSSVISDINFHLNNLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-09-13" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A099</accession>
    <name>A0A5N4A099_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PiggyBac transposable element-derived protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_15718</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000822">
        <property type="protein sequence ID" value="KAB0790726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A099"/>
    <dbReference type="InParanoid" id="A0A5N4A099"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0790726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="166" mass="19200" checksum="3791ACD919788C98" modified="2020-02-26" version="1" fragment="single">HIKKSVKSDFTTINATKEYEINLIEDNVNHLSETNDIQIPNQKLPLSLLPVDETIDSSNSDDQECVEESYLRNNSDSQDEDVITYNFNEKLRQWAISFNISHVAITALLTMLHVLKLPNLPKSSRTLLQTPRETTIAKMGNGHYWHNMDSKRELLTYYLRLIVQLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A0C8</accession>
    <name>A0A5N4A0C8_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_15661</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000810">
        <property type="protein sequence ID" value="KAB0790756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A0C8"/>
    <dbReference type="FunCoup" id="A0A5N4A0C8">
        <property type="interactions" value="15"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A0C8"/>
    <dbReference type="OrthoDB" id="5978988at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23992">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.20">
        <property type="entry name" value="Pheromone/general odorant binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006170">
        <property type="entry name" value="PBP/GOBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036728">
        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01395">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00708">
        <property type="entry name" value="PhBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024382223" evidence="1">
        <location>
            <begin position="17"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0790756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="129" mass="14099" checksum="F2F0DF3C03CE6B84" modified="2020-02-26" version="1">MKPLLVLCLLISIAAPKKLPVAFQKMWGELAGGFQAGCAAENNLDMEAASGIITRFEAPDIAPVHCYVKCMVEKMKFMTPDGKMDKAMVVDTVHLFTNELVDSCVIQEENSCRKAYLVSLCVLNGIAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A0J0</accession>
    <name>A0A5N4A0J0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SPIN-DOC-like zinc-finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_15132</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000735">
        <property type="protein sequence ID" value="KAB0790830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A0J0"/>
    <dbReference type="InParanoid" id="A0A5N4A0J0"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040647">
        <property type="entry name" value="SPIN-DOC_Znf-C2H2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45913">
        <property type="entry name" value="EPM2A-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45913:SF5">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR II-I REPEAT DOMAIN-CONTAINING PROTEIN 2A-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18658">
        <property type="entry name" value="zf-C2H2_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SPIN-DOC-like zinc-finger" evidence="1">
        <location>
            <begin position="21"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0790830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="609" mass="70574" checksum="8215F17B828C2F00" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A244</accession>
    <name>A0A5N4A244_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acyl-aliphatic-L-amino acid amidohydrolase</fullName>
            <ecNumber evidence="3">3.5.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">N-acyl-L-amino-acid amidohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PPYR_03117</name>
        <name evidence="13" type="ORF">PPYR_03195</name>
        <name evidence="14" type="ORF">PPYR_11581</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M20A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.14" evidence="3"/>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0794742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A244"/>
    <dbReference type="InParanoid" id="A0A5N4A244"/>
    <dbReference type="OrthoDB" id="3064516at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004046">
        <property type="term" value="F:aminoacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000019">
        <property type="entry name" value="Aminoacylase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052083">
        <property type="entry name" value="Aminoacylase-1_M20A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010159">
        <property type="entry name" value="N-acyl_aa_amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01880">
        <property type="entry name" value="Ac-peptdase-euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45892">
        <property type="entry name" value="AMINOACYLASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45892:SF1">
        <property type="entry name" value="AMINOACYLASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036696">
        <property type="entry name" value="ACY-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00758">
        <property type="entry name" value="ARGE_DAPE_CPG2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00759">
        <property type="entry name" value="ARGE_DAPE_CPG2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="11">
        <location>
            <begin position="188"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="370"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR036696-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR036696-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAB0791317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAB0791395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAB0794742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="398" mass="44794" checksum="CAE930E505A569E1" modified="2020-02-26" version="1">MDLSSKELDTIAVENFRRYLRIPSVHPDIDYEPCVEFLETQAKDIGLQFRVFRDVPKNPMVVLTWPGKERSLPSVMLNSHMDVVPVFEENWTHRPFDADIDEKGDIYARGAQDTKSTGIQYLEAIRRLKIQGVRPRRTVHVTFVPDEELGGGEGVMKYVETDNFKGLKVGFAIDEGRSGNGKTLVVQYGEKRNWKFAVHCPGKSGHGSLLLKNTPGEKLRAILNKLYAFRAEQKAKEDREKSGDHVTTVNLTIMRGGVQGNVIPEEFVLVFDLRIPVEDYDSVEGRVKEWCKSAGEGVWIEDILKDGDSPNTATDESNVFWVAFNEASKKMGYEIQLIIARGNTDGRFLRSVGIPTFGFGAKQDTPIRAHADDEFLNVDVFLQGIQIYKEIIIAVANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-06-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A261</accession>
    <name>A0A5N4A261_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_03186</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A261"/>
    <dbReference type="InParanoid" id="A0A5N4A261"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0791386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="170" mass="18068" checksum="86F57CF7880E4CA8" modified="2020-02-26" version="1">MSKLAPDCTVCCLLLDACPVLPSQLDNATNTATPNTQVFTEHQGRGRGEMIGAARGGNIAQGTSQQPTNYAQQTISTNPTSVFGQPTPFSGQAVSQQQFGGVTRLQQHKGVPQVIPTIGAPLQQQQPQQQQQQQQGPNLMQKLNEITAPGGDILSKGKELIFMKFGLGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A3F8</accession>
    <name>A0A5N4A3F8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_03646</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A3F8"/>
    <dbReference type="InParanoid" id="A0A5N4A3F8"/>
    <dbReference type="OrthoDB" id="1684102at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF340">
        <property type="entry name" value="AMINO ACID TRANSPORTER TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="266"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="361"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="418"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="6">
        <location>
            <begin position="36"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0791846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="453" mass="49900" checksum="3A09DD603915AACB" modified="2020-02-26" version="1">MDDDARSRIAEITTRYVVDVTDDDYDPYVHRNVEHATSYLETLVHILKASLGTGVLAMPIAFKYAGLVNGVIGAILTAFVCGVGIHRFFASQYTICKNLKVSYMPYSVIMKVALLSGPRCMSKVANFFGTLSDALLLLHQTGVCAVYVIFISNNLKDLLKRPYTNLNVPVEYYMLCLLPALLLIVSVPNMKKMARITLLSNCATLVSVIIIIAVLSPNLPDISLRHKTGTVFDSALAFGIMLFALSAMGVILTVEKHMKEPKQMVAYFGTLNVSLVAILIVYTLIGFIGYWQVGDEVKDIIILDLQNYNETARQCAQSLYVVAIFVSYGLSAMVFVDVLWGNYLKHYLAESRHHDKGQCATRILVVFVSTFAAAAIPLFADIVALLGSFSMSSLELIFPAIMDICVRWPDKFGRGKWTLIADLILMAIGVGGLLIGGFSAIRSIVRHLNELRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A3Z3</accession>
    <name>A0A5N4A3Z3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">tRNA-specific adenosine deaminase 1</fullName>
            <ecNumber evidence="8">3.5.4.34</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">tRNA-specific adenosine-37 deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PPYR_13988</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Specifically deaminates adenosine-37 to inosine in tRNA-Ala.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>adenosine(37) in tRNA(Ala) + H2O + H(+) = inosine(37) in tRNA(Ala) + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:50968"/>
            <dbReference type="Rhea" id="RHEA-COMP:12855"/>
            <dbReference type="Rhea" id="RHEA-COMP:12856"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:82852"/>
            <dbReference type="EC" id="3.5.4.34"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>1D-myo-inositol hexakisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the ADAT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.34" evidence="8"/>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A3Z3"/>
    <dbReference type="FunCoup" id="A0A5N4A3Z3">
        <property type="interactions" value="1648"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A3Z3"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043829">
        <property type="term" value="F:tRNA-specific adenosine-37 deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002466">
        <property type="entry name" value="A_deamin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46516">
        <property type="entry name" value="TRNA-SPECIFIC ADENOSINE DEAMINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46516:SF1">
        <property type="entry name" value="TRNA-SPECIFIC ADENOSINE DEAMINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02137">
        <property type="entry name" value="A_deamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00552">
        <property type="entry name" value="ADEAMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50141">
        <property type="entry name" value="A_DEAMIN_EDITASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="A to I editase" evidence="12">
        <location>
            <begin position="49"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAB0792027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="381" mass="42424" checksum="48AD2D252395D9AA" modified="2020-02-26" version="1">MSHDRIASLSIEHFNRLPKMGKPSVNTEWTVLCCIVKENTLDDNFEVVSLGTGSKCIGKSKMSATGDVLNDSHAEVVCRRAFLCYVYEQINLGTSDVFTLELGECSLNSFIKFHFFTTHVPCGDAAIFPKQDATEFGTVVADEYVHDAKKPRLDDIYRTGAKSIPGGGQDSHLQGAEYHALGVVRTKPGRGDPTLSVSCSDKLAKWYHLGIQGALLSLLLVHPIYLSSFTIANGTPFDEKSLLRALYGRFGEDAERAVIGRSSINFSFAKDVSKRPCPASIVWFKCSTGSHEVAIEGLKQGVTKKNRHARSARLQICKIEMFRRFLTAAEFLRLPSCKNFVFYDDAKADAKDYQRKWAALKVDKFKSWTSKDGKLQHFVLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A492</accession>
    <name>A0A5N4A492_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PPYR_14104</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A492"/>
    <dbReference type="InParanoid" id="A0A5N4A492"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008395">
        <property type="term" value="F:steroid hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006805">
        <property type="term" value="P:xenobiotic metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20651">
        <property type="entry name" value="CYP15A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000036">
        <property type="entry name" value="CYtochrome P450 family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050182">
        <property type="entry name" value="Cytochrome_P450_fam2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300:SF376">
        <property type="entry name" value="CYTOCHROME P450 15A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300">
        <property type="entry name" value="CYTOCHROME P450 508A4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024321962" description="Cytochrome P450" evidence="10">
        <location>
            <begin position="21"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="437"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0792145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="493" mass="56765" checksum="0CF6A1B8404E38DE" modified="2020-02-26" version="1">MLALLVVVLLVLILVCVLDTRKPKGYPPGPKWWPIVGNYLQFRRRLTVLGYHHLVHEEFSRTYGPVVCFKMGRNIVVTVSGVEAIREVLTRDEFDGRPDGFFFRLRTFGKRLGIVFSDGKLWQRQRKFSLQHLKNFGFGKREMEAKIAEETRDLIEDLRKKSSDLVFMHNAFDVGVLNVLWTMMAGERFTLDDVRLIKLLQIVHDAFRLFDMSGGLLNQLPVLRFLAPGCCGYTKTVEILKRMWLFLEETIAEHRKTACSSHSRDLIDAFLREMQITSDSDSGFTDEQLLSLCLDLFMAGSETTSNTLGFAVLYMVKYPGVQKRVQEEMDEVVGRNRWPTMNDKINLPYTEAVLMETQRLANVPPLGVAHRATRTTNLFGYTVPEGAIVLTSLYSIHMDDAFWKDPKEFRPDRFLRDGKVTCPEWSFLPFGYGKRRCLGESLAKTNYFLFFTAMLHNFFLHKDPDTTEVVTDGCDGVTISPRPFRVRLASRYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A4G6</accession>
    <name>A0A5N4A4G6_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_14175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A4G6"/>
    <dbReference type="InParanoid" id="A0A5N4A4G6"/>
    <dbReference type="OrthoDB" id="6756422at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23992">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.20">
        <property type="entry name" value="Pheromone/general odorant binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006170">
        <property type="entry name" value="PBP/GOBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036728">
        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01395">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024322128" evidence="1">
        <location>
            <begin position="19"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0792216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="134" mass="15292" checksum="0D11A2E35DE05A57" modified="2020-02-26" version="1">MNAFGIFAAILFLQAAMAYKDFKEESDWCIERHGLSADKIYRIHRGGHLPSTDDDYLTFIECLWRKIRFLNSRGELNLAEIWGMYYEVAHEIYNHQVSAVKADAVLKKCKGVNGDTPALRAVNMGNCLKNVANY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A4N8</accession>
    <name>A0A5N4A4N8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutathione transferase</fullName>
            <ecNumber evidence="2">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PPYR_14236</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the GST superfamily. Sigma family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="2"/>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A4N8"/>
    <dbReference type="FunCoup" id="A0A5N4A4N8">
        <property type="interactions" value="320"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A4N8"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03192">
        <property type="entry name" value="GST_C_Sigma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03039">
        <property type="entry name" value="GST_N_Sigma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000030">
        <property type="entry name" value="Glutathione S-transferase S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000035">
        <property type="entry name" value="hematopoietic prostaglandin D synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050213">
        <property type="entry name" value="GST_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571:SF224">
        <property type="entry name" value="HEMATOPOIETIC PROSTAGLANDIN D SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01205">
        <property type="entry name" value="AMPS.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00363">
        <property type="entry name" value="AMPS_(cytGST):_Alpha-__Mu-__Pi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="6">
        <location>
            <begin position="3"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="7">
        <location>
            <begin position="82"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0792277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="204" mass="23583" checksum="455996D258A4AD22" modified="2020-02-26" version="1">MAPAYKLKYFPSKALGEPIRFLMSYGNIEFEDVRLIREDWPQIKPTMPFGQAPVLEFKGITAYQSIAICRYLAKQVKLTGANDLEDWEIDAIVDTVNDLRGRIDEYYYEEDAEAKEKRKKPLFEETLPFYMERIEAIVKKNNGHLAVGKLTWADLHFVGVLDYLNYMIGKNLIADYPSLQAMEKNVLNLPGIKEWVAKRPVTIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A5M5</accession>
    <name>A0A5N4A5M5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_14603</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the methyltransferase superfamily. METTL16/RlmF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A5M5"/>
    <dbReference type="FunCoup" id="A0A5N4A5M5">
        <property type="interactions" value="2191"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A5M5"/>
    <dbReference type="OrthoDB" id="514248at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017182">
        <property type="entry name" value="METTL16/PsiM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010286">
        <property type="entry name" value="METTL16/RlmF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13393:SF0">
        <property type="entry name" value="RNA N6-ADENOSINE-METHYLTRANSFERASE METTL16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13393">
        <property type="entry name" value="SAM-DEPENDENT METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05971">
        <property type="entry name" value="Methyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037350">
        <property type="entry name" value="Mtase_ZK1128_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR037350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR037350-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0792644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="476" mass="54279" checksum="E983E836ADBB1CBB" modified="2020-02-26" version="1">MAMNKYMHPRNIYKKPPNFKQLAVDYPEFRSFIIQDVTGKVSIDFKDAKTLRALTCTLMKKDFGLDVDIPLTRMIPTVPLRLNYILWLEDLLNISPTSDDIKGVDIGTGASCIYPLLGAKSKGWHMIGTDVDAESLEWAQRNVDRNSLGSLIKLKKVTDGVILKEAIEGEFDFCMCNPPFFASAPELNPQHKARRIDRPRPRNAFCASTNEVIADGGEVNFIQKMIKESKELGKSIRIYSTMVGHKYNLPQLKKLLREVDVISFKQTDFYQGKTTRWGLAWTFHDIDLRTLPEATVACAKKLKSKVPLHHKFVSQHVPEVAKMLTDIFEKLQCHVEVVKQQKTMVHYHITASSNTWSHQRRKRREEERLKTLLGDNNNCPASTSEEIKSTSELIANMNVSSPKGPSKRELEEEGYYNIKRIKMDSGDIYEECFLKCSVIVKKDSSDVAVDFVFIEGLAGREGVHQIFQYVKNNIKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A5V1</accession>
    <name>A0A5N4A5V1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TP53-regulated inhibitor of apoptosis 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_14641</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 1,2-diacyl-sn-glycero-3-phosphate(in) = a 1,2-diacyl-sn-glycero-3-phosphate(out)</text>
            <dbReference type="Rhea" id="RHEA:36435"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRIAP1/MDM35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A5V1"/>
    <dbReference type="FunCoup" id="A0A5N4A5V1">
        <property type="interactions" value="1027"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A5V1"/>
    <dbReference type="OrthoDB" id="19091at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990050">
        <property type="term" value="F:phosphatidic acid transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007918">
        <property type="entry name" value="MDM35_apoptosis"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46403">
        <property type="entry name" value="TP53-REGULATED INHIBITOR OF APOPTOSIS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46403:SF1">
        <property type="entry name" value="TP53-REGULATED INHIBITOR OF APOPTOSIS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05254">
        <property type="entry name" value="UPF0203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0792682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="80" mass="9324" checksum="8F82474C139BEF92" modified="2020-02-26" version="1">MNSIGDACKPLKDEYDACFNTWFSEQFLKGRTNDSMCEPLFRVYQDCVKKVMKEQNIEIQEVEKDLLGTNSERKVPPKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A617</accession>
    <name>A0A5N4A617_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Fucosyltransferase</fullName>
            <ecNumber evidence="12">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PPYR_14710</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">1611_PpyrPB1</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Golgi apparatus</location>
            <location evidence="1 12">Golgi stack membrane</location>
            <topology evidence="1 12">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the glycosyltransferase 10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="12"/>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A617"/>
    <dbReference type="FunCoup" id="A0A5N4A617">
        <property type="interactions" value="27"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A617"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008417">
        <property type="term" value="F:fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11660:FF:000006">
        <property type="entry name" value="Alpha-(1,3)-fucosyltransferase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11660">
        <property type="entry name" value="Glycosyl transferase family 10, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055270">
        <property type="entry name" value="Glyco_tran_10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031481">
        <property type="entry name" value="Glyco_tran_10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001503">
        <property type="entry name" value="Glyco_trans_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038577">
        <property type="entry name" value="GT10-like_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48438">
        <property type="entry name" value="ALPHA-(1,3)-FUCOSYLTRANSFERASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48438:SF1">
        <property type="entry name" value="ALPHA-(1,3)-FUCOSYLTRANSFERASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17039">
        <property type="entry name" value="Glyco_tran_10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00852">
        <property type="entry name" value="Glyco_transf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="Fucosyltransferase N-terminal" evidence="14">
        <location>
            <begin position="33"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Fucosyltransferase C-terminal" evidence="13">
        <location>
            <begin position="164"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAB0792751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="363" mass="42774" checksum="3D69C6DB91EFC788" modified="2020-02-26" version="1">MKRYIQLRFVLILVIILIIIFAVQDFHTLRKNDRKSILYWTPFWWHEDFEVGFGDEPFENCEYTNCFATNDRHFMEISEFDAVIFHASIYDPKIHGKPRRRTAKQVYIFCNMEAPVYIAPNFSQYDSFYNWTMTYRFDSDIVSRHGQFMEEESNYTLSSVSAIQKKTKLIAWFVSHCKTSSQREVLVAELQRFLPVDVYGLCGPLACEKTQRNELSSPKCYDMLEEDYKFYLSFENSLCKDYSTEKLYNALRKNVVPIVYGAGDYNMSAPPGSVINVADFETVEQLADHLWYLHENATAYLEYFHWKKRYKIAKVQKACEICRKLNLPQRTSIYHNLLEWSKGSRGEICKIGSDLPNILRNAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A6L9</accession>
    <name>A0A5N4A6L9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UPAR/Ly6 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_12529</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0792909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A6L9"/>
    <dbReference type="InParanoid" id="A0A5N4A6L9"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024271085" description="UPAR/Ly6 domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0792909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="110" mass="12052" checksum="E83352DA2F7B3705" modified="2020-02-26" version="1">MHLRPLLPVGLLLFIVGTGSCLSCLLCKDLLDCKGNTTEKIECHMMEDVCFQIFHPETGAVFRRACGAPTVCDIYAKCSTCNVNDCNSSMNILPSFLMISLATVIAMKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2024-03-27" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A798</accession>
    <name>A0A5N4A798_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Core-binding (CB) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_12826</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A798"/>
    <dbReference type="InParanoid" id="A0A5N4A798"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35617:SF3">
        <property type="entry name" value="CORE-BINDING (CB) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35617">
        <property type="entry name" value="PHAGE_INTEGRASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47823">
        <property type="entry name" value="lambda integrase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0793206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="155" mass="17739" checksum="E37C6508CA89D07F" modified="2020-02-26" version="1" fragment="single">KSRSSPSKITFPGFVQVIREAYRLRGIPPESFELFTNSISSATLKQYSSALSRWWYFCGTHGCDFYNSSHSDIIKFLTVEFNKGVSFSYLNVIRSAISFVRGNDLVNNLEVKRLFKGIFRSRPPRRKYDSIWDPNARILMIVISGTVQVQTGLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A7P3</accession>
    <name>A0A5N4A7P3_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_12929</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A7P3"/>
    <dbReference type="InParanoid" id="A0A5N4A7P3"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024354132" evidence="2">
        <location>
            <begin position="23"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0793309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="350" mass="39457" checksum="608ACDC05401A31A" modified="2020-02-26" version="1">MIFLYLYHIYTVFVITGSKADSKEKDDKKKPGDKRDSSEKGGKGGLKEKDDKKKPGGKGDSKEKDDQKKPDGDKRDSSEKGNSSEEDKGNKGDSKEKDDKKKPGDKQDSSEKGNSSEEGQGDKGGSKEKDDQKKPGDKGDSKENNSSEEGGHQNDDENTPDKNCTHCKNLRTIYDYGGCRVLCRGKKSHCPTKYTCISLIDRYMEDTSRCMYNNIYYRLGHVLSGSYPNLNNIQTCSYVCRYDSKLKMSRFVEENCRPVDKPKTRLCKDVINMNMPFLLETKLGVKYSPRTCKIELVTADPSLLPESNCVAHPRSGRCCYMYDRKYSRRTVLPPNVANCTCTCPPLLECH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A8T7</accession>
    <name>A0A5N4A8T7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_13366</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A8T7"/>
    <dbReference type="FunCoup" id="A0A5N4A8T7">
        <property type="interactions" value="68"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A8T7"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252">
        <property type="entry name" value="ACROSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252:SF7">
        <property type="entry name" value="HYALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024417621" description="Peptidase S1 domain-containing protein" evidence="3">
        <location>
            <begin position="17"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="4">
        <location>
            <begin position="244"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="45"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0793746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="411" mass="45716" checksum="6D6779325FD7525D" modified="2020-02-26" version="1">MGVYCMILIYFATISGEFVCSNPSGSQEARIHDTLETYRRQSTQCKSDQFHCDSNDCISKEKVCDGKADCPNSDDEKLKECAEVTKEPPPGACLIPNHPNNGEYRLGLGNSTPGEYAPMYKVLVLQCEEPQYKPYPPALGVGADLPLCIDGKWSPTPPTCAPACKPLQSTTTTKVTCKHGDKILDNCDNPVHNTVAVFECEPFHEMPELSLNPDILCLNGSWDYPVPQCLPVCGHKRPKNVPHLVGDVTEKKSDYPWHVAVFNATNDNICGGSIISQRLVLSAAHCFTDQDGKLYPFEDYKIVAGKYYRNYDDPRDHGAQESAIEHIYIAPKYKAMYNYYEADLAIIVLKERLKVTGDVQPFGIDPPFLLYNCLWSSPTHLQTVESSKCRSLNLNTHPLDEKVSVFGPSHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A9C6</accession>
    <name>A0A5N4A9C6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PPYR_13545</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">1611_PpyrPB1</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A9C6"/>
    <dbReference type="FunCoup" id="A0A5N4A9C6">
        <property type="interactions" value="66"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A9C6"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11056">
        <property type="entry name" value="CYP6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000042">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050476">
        <property type="entry name" value="Insect_CytP450_Detox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292:SF54">
        <property type="entry name" value="CYP9F3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0492">Microsome</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="447"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAB0793925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="507" mass="58870" checksum="5E05193B227E2099" modified="2020-02-26" version="1">MWTIILLVFLTFVIYRHFKKSLIYWKEQNVQHDRPFPIFGNMLPILLGKISNVEMIQKLYNKYSSGRYVGLYNFGATSLVLRDPELIKKITVKEFETFPEHRPFIPSDVDPLWSNNLFAMEGGEKWHQLRSTLSPSFTSSKMKAMFVLMKECTKEFINYFESKGDSVDVELKDSFARFGNDVIATTAFGVTCNSLSDPKNEFYVLGKELMNFKGLRRIIFMLNLICPTMARITRVSFFPEKIRKFFGSLIKETLQLRREKKVVRPDMIHLLMEYQKENPTQEEDAHSTPEAGFAVVEESVFGKTKQKLKLEVTDDIITSQVMIFFFAGLDTVSTMMSYTIYELALNPDIQSRLRAEIEDALRSSDGKLTYDNLMRMKYLDMVISGPTETPVFLQKHSHVICPIFAIHRDPKYYHNPDKFDPERFNDENRSSIHPYTYLPFGAGPRNCIGSRFALLEGKLIIAEIVRNFEIVPVRKTQVPIVFSTTNFNPLPDNGIWVGFRRRKEDEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AD05</accession>
    <name>A0A5N4AD05_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 15">NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial</fullName>
            <ecNumber evidence="15">7.1.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PPYR_08152</name>
        <name evidence="17" type="ORF">PPYR_12033</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 19" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">1611_PpyrPB1</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">1611_PpyrPB1</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29091"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="7.1.1.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:29092"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 15">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="13">Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme. Interacts with RAB5IF.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Mitochondrion inner membrane</location>
            <topology evidence="15">Peripheral membrane protein</topology>
            <orientation evidence="15">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the complex I 51 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.2" evidence="15"/>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0795194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AD05"/>
    <dbReference type="FunCoup" id="A0A5N4AD05">
        <property type="interactions" value="1273"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AD05"/>
    <dbReference type="OrthoDB" id="42889at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1440.230:FF:000001">
        <property type="entry name" value="Mitochondrial NADH dehydrogenase flavoprotein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.600:FF:000001">
        <property type="entry name" value="NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11540:FF:000001">
        <property type="entry name" value="NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11540">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 51kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.230">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 51kDa subunit, iron-sulphur binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050837">
        <property type="entry name" value="ComplexI_51kDa_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001949">
        <property type="entry name" value="NADH-UbQ_OxRdtase_51kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011537">
        <property type="entry name" value="NADH-UbQ_OxRdtase_suF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011538">
        <property type="entry name" value="Nuo51_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037225">
        <property type="entry name" value="Nuo51_FMN-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019575">
        <property type="entry name" value="Nuop51_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037207">
        <property type="entry name" value="Nuop51_4Fe4S-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054765">
        <property type="entry name" value="SLBB_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01959">
        <property type="entry name" value="nuoF_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010120">
        <property type="entry name" value="PRK13596.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11780:SF10">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11780">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE FLAVOPROTEIN 1 NDUFV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01512">
        <property type="entry name" value="Complex1_51K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10589">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22461">
        <property type="entry name" value="SLBB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00928">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142019">
        <property type="entry name" value="Nqo1 FMN-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142984">
        <property type="entry name" value="Nqo1 middle domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140490">
        <property type="entry name" value="Nqo1C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00644">
        <property type="entry name" value="COMPLEX1_51K_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00645">
        <property type="entry name" value="COMPLEX1_51K_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 15" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="15" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 15" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 15" id="KW-0288">FMN</keyword>
    <keyword evidence="10 15" id="KW-0408">Iron</keyword>
    <keyword evidence="11 15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12 15" id="KW-0520">NAD</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="15" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="15" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding" evidence="16">
        <location>
            <begin position="378"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00046881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU364066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAB0795194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAB0797158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="477" mass="52317" checksum="6838F443DE7C9B6D" modified="2020-02-26" version="1">MANVLIRFSYLTKNQIGALGPISCSHVQHYSTPPPGTPPAQTKTKFGPLADQDRIFTNLYGTHDWRLKGALKRGDWYKTKEMICKGADWIINEIKVSGLRGRGGAGFPSGMKWSFMVKPGDGRPKYLVINADEGEPGTCKDRDIMRHDPHKLVEGCLLAGSAMGAKAAYIYIRGEFYNEASNMQVAIAEAYQAGLLGKNACGSGYDFDVFMHRGAGAYICGEETALIESLEGKQGKPRLKPPFPADVGVFGCPTTVTNVETVAVAPTILRRGGAWFASFGRTRNSGTKLFNISGHIVNPCTVEEEMSIPLRELIEKHAGGVTGGWDNLLAIIPGGSSTPLIPKSVCDDAIMDFDGLVACQTSLGTAAIIVMNKQTDIVKAIARLIMFYKHESCGQCTPCREGISWMNKMMYRFVDGNARPDEIDMLWELSKQIEGHTICALGDGAAWPVQGLIRHFRPELEMRMEKFHQQNQQKMSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AEL9</accession>
    <name>A0A5N4AEL9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PPYR_09810</name>
        <name evidence="7" type="ORF">PPYR_10271</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0795749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AEL9"/>
    <dbReference type="FunCoup" id="A0A5N4AEL9">
        <property type="interactions" value="554"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AEL9"/>
    <dbReference type="OrthoDB" id="19923at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032956">
        <property type="term" value="P:regulation of actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035020">
        <property type="term" value="P:regulation of Rac protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.555.10:FF:000001">
        <property type="entry name" value="Rho GTPase activating protein 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047165">
        <property type="entry name" value="RHG17/44/SH3BP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14130">
        <property type="entry name" value="3BP-1 RELATED RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14130:SF14">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 92B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00721">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAR" evidence="5">
        <location>
            <begin position="15"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="4">
        <location>
            <begin position="245"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="474"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="805"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="155"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="544"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="805"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="829"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="842"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="867"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="892"/>
            <end position="901"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0795749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0796210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="901" mass="100864" checksum="0C72DAD45D4EA792" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AEP9</accession>
    <name>A0A5N4AEP9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SH2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_09866</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0795805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AEP9"/>
    <dbReference type="InParanoid" id="A0A5N4AEP9"/>
    <dbReference type="OrthoDB" id="10044490at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0727">SH2 domain</keyword>
    <feature type="domain" description="SH2" evidence="3">
        <location>
            <begin position="377"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="84"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="195"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="101"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0795805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="481" mass="54966" checksum="947DDC29CCE8A3BA" modified="2020-02-26" version="1">MPNQILLFKEIESLNNNQLINALELNGYGECVAAIRAKNIDGDQFLKLTEVQISLWRLPITQSRRLWSFIQLIKSDPTQLLHTARTSNHSKSKNITKLKSNESVESSKGSSLTKQESVLLRNKLEDMFKKDIEEMPNPSFIHQQRYPQLPLKPKHLQQKREETQEPMDDNDGYLSPIHVEPRHEETFLSKYRRASASFEKDTDKPKLPLRGRPLPPLPIQQTLPSNKDDPEEELGDYTPVIEPLPNTPTNEEELPEYTPIEDEILPTTPVKRALPPIPTQQVLVSTPREPNVTSIRRLKPVPQTSDLVAPVKQNLQVKVKALPKPPKELPPEPVSLFENESLIVNKATEIALCATNAEDDYSSDEYDQVGDELKSLSYYRETDRKGARMLLTGLEEGAFVIRPSRQNKYLCTISIMHTKKMFNIGIERNSDSTLTFGDLNENTNLPPFYTIKDIINYFTTNPIPLYGEYVQLKNILPPNKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AET9</accession>
    <name>A0A5N4AET9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="25">Membrane-bound transcription factor site-1 protease</fullName>
            <ecNumber evidence="24">3.4.21.112</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="26">Endopeptidase S1P</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="34" type="ORF">PPYR_09903</name>
    </gene>
    <organism evidence="34 35">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="34 35" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="34">1611_PpyrPB1</strain>
            <tissue evidence="34">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>Processes precursors containing basic and hydrophobic/aliphatic residues at P4 and P2, respectively, with a relatively relaxed acceptance of amino acids at P1 and P3.</text>
            <dbReference type="EC" id="3.4.21.112"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus membrane</location>
            <topology evidence="3">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 27">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="34">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.112" evidence="24"/>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0795842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AET9"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:serine-type endopeptidase activity"/>
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        <property type="term" value="P:cholesterol metabolic process"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Peptidases_S8_SKI-1_like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Membrane-bound transcription factor site-1 protease preproprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="MBTP1_N"/>
    </dbReference>
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        <property type="entry name" value="MBTPS1_3rd"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
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        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
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        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
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        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034185">
        <property type="entry name" value="Site-1_peptidase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF7">
        <property type="entry name" value="MEMBRANE-BOUND TRANSCRIPTION FACTOR SITE-1 PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23001">
        <property type="entry name" value="MBTP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23094">
        <property type="entry name" value="MBTPS1_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23090">
        <property type="entry name" value="MBTPS1_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="14" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0153">Cholesterol metabolism</keyword>
    <keyword evidence="12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="21" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="16" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 27" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="17" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="18 28" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7 27" id="KW-0645">Protease</keyword>
    <keyword evidence="35" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13 27" id="KW-0720">Serine protease</keyword>
    <keyword evidence="9 29" id="KW-0732">Signal</keyword>
    <keyword evidence="22" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="20" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="8 28" id="KW-0812">Transmembrane</keyword>
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    <keyword evidence="19" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="29">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024306226" description="Membrane-bound transcription factor site-1 protease" evidence="29">
        <location>
            <begin position="22"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="28">
        <location>
            <begin position="996"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="domain" description="Membrane-bound transcription factor site-1 protease-like N-terminal" evidence="31">
        <location>
            <begin position="47"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="30">
        <location>
            <begin position="201"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="MBTPS1 third" evidence="33">
        <location>
            <begin position="478"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="domain" description="MBTPS1 fourth" evidence="32">
        <location>
            <begin position="608"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="27">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="27">
        <location>
            <position position="241"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="27">
        <location>
            <position position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
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            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00066596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00067283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00081324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="31">
        <source>
            <dbReference type="Pfam" id="PF23001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="32">
        <source>
            <dbReference type="Pfam" id="PF23090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="33">
        <source>
            <dbReference type="Pfam" id="PF23094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="34">
        <source>
            <dbReference type="EMBL" id="KAB0795842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="35">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1035" mass="116098" checksum="91398F8C9E7D7023" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AEW4</accession>
    <name>A0A5N4AEW4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed DNA polymerase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_09910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0795849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511">
        <property type="entry name" value="PROTEIN CBG23764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511:SF12">
        <property type="entry name" value="RHO TERMINATION FACTOR N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0795849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="914" mass="106343" checksum="8AB07410A38CF08C" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AG22</accession>
    <name>A0A5N4AG22_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_10314</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
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            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AG22"/>
    <dbReference type="InParanoid" id="A0A5N4AG22"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0796253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="195" mass="22874" checksum="4F8A7B736956995A" modified="2020-02-26" version="1">MSNNQAMLNLRSRQLNPCDVLYWKCRGYQERPDNWEELAYEINNDENEEYDEEDEEDYEDEEDYEDEEDYEEEDEEDYEDEEDYYDAEHAQYSNERNPNNDAYWRARGWQARPENWREYMYAPQKKSSTSSSSSAPTGRQNRVSTVSTVPTCQQMASISVSAVSAGRREASRTSAQLASRAKPTSAVHENIYSVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AG74</accession>
    <name>A0A5N4AG74_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">15-hydroxyprostaglandin dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_10364</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AG74"/>
    <dbReference type="FunCoup" id="A0A5N4AG74">
        <property type="interactions" value="119"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AG74"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000149">
        <property type="entry name" value="15-hydroxyprostaglandin dehydrogenase [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229:SF8">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0796303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="265" mass="29189" checksum="2882D1F7E9413521" modified="2020-02-26" version="1">MFKLEGKVALITGGASGIGLSTVKELLANGLKAITVVDFNETAGQRVIEEVTEEFGANRAIFVKADVGNVTEFRGAFEATVEKFDNLDIVINNAGIMNEIEWEKMINTNINGTIHGCLLALDYLQRYRRAIEGVIINISSIMGLQTAGHTPFYNTTKHAIVGLGRSLGLHGHYESTAVKVITICPGCTATPLLLENMEERFSKKQIEMHTEVMKKFQLQSANNVARELTAIIKHGQSGSVWLIENDEPAYQVETPHYSDMRVPHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AGD3</accession>
    <name>A0A5N4AGD3_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PPYR_10329</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VEFS (VRN2-EMF2-FIS2-SU(Z)12) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AGD3"/>
    <dbReference type="FunCoup" id="A0A5N4AGD3">
        <property type="interactions" value="2007"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AGD3"/>
    <dbReference type="OrthoDB" id="166746at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035098">
        <property type="term" value="C:ESC/E(Z) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016586">
        <property type="term" value="C:RSC-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21740">
        <property type="entry name" value="C2_II_SUZ12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21551">
        <property type="entry name" value="VEFS-box_SUZ12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21750">
        <property type="entry name" value="ZnB-Zn_SUZ12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019135">
        <property type="entry name" value="Polycomb_protein_VEFS-Box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057540">
        <property type="entry name" value="Znf_SUZ12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22597">
        <property type="entry name" value="POLYCOMB GROUP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22597:SF0">
        <property type="entry name" value="POLYCOMB PROTEIN SUZ12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09733">
        <property type="entry name" value="VEFS-Box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23320">
        <property type="entry name" value="Zn_SUZ12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Polycomb protein SUZ12-like zinc finger" evidence="10">
        <location>
            <begin position="329"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="Polycomb protein VEFS-Box" evidence="9">
        <location>
            <begin position="457"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="632"/>
            <end position="679"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0796268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="679" mass="77354" checksum="7DC9AD2C8E9FCFA2" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-06-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AHM5</accession>
    <name>A0A5N4AHM5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">C-CAP/cofactor C-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_07647</name>
        <name evidence="2" type="ORF">PPYR_10913</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AHM5"/>
    <dbReference type="InParanoid" id="A0A5N4AHM5"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017901">
        <property type="entry name" value="C-CAP_CF_C-like"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51329">
        <property type="entry name" value="C_CAP_COFACTOR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-CAP/cofactor C-like" evidence="1">
        <location>
            <begin position="49"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0796852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0799767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="94" mass="10546" checksum="545EB099FF26766E" modified="2020-02-26" version="1">MENNNTDELCVPGDIEEAAKRATFELLPKKSAQQYDIAYCNFLSWCRIKKDMIANGQEINKSVNSNLLQSSLNSQGINISNCSNCTIHINVHKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AI10</accession>
    <name>A0A5N4AI10_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">EXS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PPYR_10977</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SYG1 (TC 2.A.94) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AI10"/>
    <dbReference type="FunCoup" id="A0A5N4AI10">
        <property type="interactions" value="1111"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AI10"/>
    <dbReference type="OrthoDB" id="9970435at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000822">
        <property type="term" value="F:inositol hexakisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016036">
        <property type="term" value="P:cellular response to phosphate starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14477">
        <property type="entry name" value="SPX_XPR1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004342">
        <property type="entry name" value="EXS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10783:SF103">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 53 MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10783">
        <property type="entry name" value="XENOTROPIC AND POLYTROPIC RETROVIRUS RECEPTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03124">
        <property type="entry name" value="EXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03105">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51380">
        <property type="entry name" value="EXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="302"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="330"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="359"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="458"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="488"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="536"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="domain" description="SPX" evidence="9">
        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="EXS" evidence="8">
        <location>
            <begin position="417"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="69"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0796916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="659" mass="77243" checksum="2F7801EA3EBB79C2" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AI84</accession>
    <name>A0A5N4AI84_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dipeptidase</fullName>
            <ecNumber evidence="1">3.4.13.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_10989</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an L-aminoacyl-L-amino acid + H2O = 2 an L-alpha-amino acid</text>
            <dbReference type="Rhea" id="RHEA:48940"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:59869"/>
            <dbReference type="ChEBI" id="CHEBI:77460"/>
            <dbReference type="EC" id="3.4.13.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer; disulfide-linked.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.13.19" evidence="1"/>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AI84"/>
    <dbReference type="FunCoup" id="A0A5N4AI84">
        <property type="interactions" value="7"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AI84"/>
    <dbReference type="OrthoDB" id="445695at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070573">
        <property type="term" value="F:metallodipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01301">
        <property type="entry name" value="rDP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008257">
        <property type="entry name" value="Pept_M19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10443:SF12">
        <property type="entry name" value="DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10443">
        <property type="entry name" value="MICROSOMAL DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01244">
        <property type="entry name" value="Peptidase_M19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51365">
        <property type="entry name" value="RENAL_DIPEPTIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0224">Dipeptidase</keyword>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU341113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0796928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="501" mass="55711" checksum="3C0C303889C2CE2C" modified="2020-02-26" version="1">MAVTGRGSLRDPWVLDSELRNHIQHCPCACNHMGYGNYLDYQIPPIPHEFPEETSFNVVPQYYDSSGYHYHEYQDSSFDSCSCSTDSTTSSRTSFRNPWCICLVVCVIVAALGIGLGLPLALHPDLPMHTPEERLMAVRRLLRETPLIDGHNDLAWNIRKFVHNKLIGFNLSDISRKEPWMRSRWSQTDIPRLKEGQLGAQFWSAYVPCGAQHLDAVQLTLEQIDAIRRLVDSNPKYFAFVKSANEILEVHKEGRIASLIGVEGGHSIGNSLAVLRMFYNLGARYLTITHTCDTSWAYGSNSQGTGGLTPFGYSVIKEMNRLGMMIDLSHTSVNTAKAALNASQAPVIFSHSSAYSLCNSSRNVPDDILKLVAHNGGVVMINFYTYLITCNETATIKDVIRHINHIRTVAGINHVGIGAGYDGINMTPSGLEDVSGYPRLLAELLADPNWSLSDIKLLAGKNILRVLAKVEAIRDQWQLAAIVPFEETLPPQDSRCAYKFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AJ98</accession>
    <name>A0A5N4AJ98_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MalT-like TPR region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_08360</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TTC19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AJ98"/>
    <dbReference type="FunCoup" id="A0A5N4AJ98">
        <property type="interactions" value="1076"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AJ98"/>
    <dbReference type="OrthoDB" id="5986190at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040395">
        <property type="entry name" value="TTC19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13143">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13143:SF6">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 19, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0797366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="335" mass="38156" checksum="A64431797AF9405C" modified="2020-02-26" version="1">MFKLCNYCKLYKNYRIPWIPLRSSSMNYNTQTLRRIANICNKKPLKAVIALNVLTWLGFVDTDKDEESELIMTIKRAILATRREQYDIAEQLLHVALRLAQQQQNENGITYCYDLMANLAFDQYDLSKAEKLFISVLQRLLSTGMEQNDLKVIHISLKLARICHLKAENEKADIGYNWCLEKIVEKQNGGADAQMLHGVIHDWYAQFLMDTGDMPNSIKHLKEAYRICVQETGHENEQSMLLLNDIGISNWRTDNLADAEECLSKAASIGNNLGDKSHVGVINANLGLVYLQRGLVEQAAKYCNIGLELGNRHENAESISQANYCLEQIKLNIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AL99</accession>
    <name>A0A5N4AL99_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_09077</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AL99"/>
    <dbReference type="FunCoup" id="A0A5N4AL99">
        <property type="interactions" value="44"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AL99"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051217">
        <property type="entry name" value="Insect_Cuticle_Struc_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236:SF95">
        <property type="entry name" value="CUTICULAR PROTEIN 76BD, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236">
        <property type="entry name" value="STRUCTURAL CONTITUENT OF CUTICLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00947">
        <property type="entry name" value="CUTICLE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024437450" evidence="3">
        <location>
            <begin position="18"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0798084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="159" mass="17341" checksum="6F9C2AA0D289CA74" modified="2020-02-26" version="1">MFFKLALIACAFVASYAQHHHGASSYASLNLGYGHHVAHAAPVAYHHAAPLIHHAAPIVHHAAPLVAHGHAAHHVDYHAHPKYEFNYGVSDAHTHDIHSQHEVRDGDAVHGEYSLHEADGTVRTVKYTADDKNGFNAVVERSGHAVHPETHAKIALKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ALM7</accession>
    <name>A0A5N4ALM7_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_09214</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ALM7"/>
    <dbReference type="FunCoup" id="A0A5N4ALM7">
        <property type="interactions" value="15"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4ALM7"/>
    <dbReference type="OrthoDB" id="6601693at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23992">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.20">
        <property type="entry name" value="Pheromone/general odorant binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006170">
        <property type="entry name" value="PBP/GOBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036728">
        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01395">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0798221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="146" mass="17186" checksum="D37319A145DECD83" modified="2020-02-26" version="1">MKYCIVHSMRPSVNVFIMLCAIMSSVELKLPPEVIVDWESYHFQYFDICVNETGVDPMIPRMMFRQVNLPDEESFHCYMKCTFKYHNMLTPDEKDIDYEAYAKDVHLTPEILKMCREFVASESEICRKTYLITKCSVENKVISSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AM53</accession>
    <name>A0A5N4AM53_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_09428</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AM53"/>
    <dbReference type="InParanoid" id="A0A5N4AM53"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0798435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="366" mass="39645" checksum="07D545530EEE86D0" modified="2020-02-26" version="1">MADFNKEKRKLIYCISQWTPDSNVQEFDIDVSDLTVLFQIMGYTLEEFERVPAIEENGESASSTGQLSTSRVQLICSKSGMKSTLTRTLKSCQCPNTQDLDKGQSWFVTGCAPSSSQSTISSSACSLIPTISKCKASIVGHLIDKAISAIKDKDTRDTETTLNLSQNALLSRHRSLDTLKAKEGSKLFSGNLSKDLSWEVDPRTSPPTQASSPSPLPDLTRTLSGLSLDASKRATLIRHLSTVQELVNEALEIAGPSSTSIKKTQKRRVSDIKPEPSTPRKKATPNRRLLSLATKHCGIPTPTFQKVVPRIASTSKYAVGVKSKFNVSSTVSAKPTGISSLYRTASKPATTASTVAKCKNPVFGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AMX0</accession>
    <name>A0A5N4AMX0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PPYR_09672</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">1611_PpyrPB1</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Microsome membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AMX0"/>
    <dbReference type="InParanoid" id="A0A5N4AMX0"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20628">
        <property type="entry name" value="CYP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000182">
        <property type="entry name" value="Cytochrome P450 3A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
        <property type="entry name" value="Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291:SF105">
        <property type="entry name" value="CYTOCHROME P450 4P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="11 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="7 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0492">Microsome</keyword>
    <keyword evidence="12 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="10 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="436"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAB0798679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="491" mass="57176" checksum="4C9D2CC2C36B8349" modified="2020-02-26" version="1">MILFIILASALTVYLIWFIYQLRKHFAPLNNVPGPTSMDMFRGILFATPADIWNYVRQLFKTYPRMFKFWHTIHAVVWLSHPDDVEVILSSMKHISKSRIYESLQPWLGTGLLTSTGTKWKERRQILTPALHFGILREFLNIFNDYSTLLVQKFEAASKEQPINIVPVITDFTLHTICETAMGTQLKTNEEQSKQYIDAIYRMGEVVIQRIACPWLQYAITFFLSGNYYRQEKLLKIMHTFSRKVIQDRKRTFSGINVNLKSKKRLALLDMLISAQLSRNDIDDDGIREEVDTFMFEGHDTTTSCISFTLLMIANHAEVQDKIVEELDAIFDNSDRLATVDDLQSMTYLEKVIKETLRICPSVPIISRSSEEDIELPSGYTIPKGTICFMHIFELHRNPEVFPNPEQFDPERFSNENSKHRHPFAYIPFSAGPRNCIGQRFAFLEVKVMVSSILRKFRLEPVDSFDKLPLVMHLILKSRDGIRIKFRKRDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AQF9</accession>
    <name>A0A5N4AQF9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ETS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_07447</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the ETS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AQF9"/>
    <dbReference type="InParanoid" id="A0A5N4AQF9"/>
    <dbReference type="OrthoDB" id="10067219at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08203">
        <property type="entry name" value="SAM_PNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000039">
        <property type="entry name" value="Friend leukemia integration 1 transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000418">
        <property type="entry name" value="Ets_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046328">
        <property type="entry name" value="ETS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003118">
        <property type="entry name" value="Pointed_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849:SF304">
        <property type="entry name" value="DNA-BINDING PROTEIN D-ETS-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00178">
        <property type="entry name" value="Ets"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02198">
        <property type="entry name" value="SAM_PNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00454">
        <property type="entry name" value="ETSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00413">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00251">
        <property type="entry name" value="SAM_PNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00345">
        <property type="entry name" value="ETS_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00346">
        <property type="entry name" value="ETS_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50061">
        <property type="entry name" value="ETS_DOMAIN_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51433">
        <property type="entry name" value="PNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNT" evidence="8">
        <location>
            <begin position="266"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="ETS" evidence="7">
        <location>
            <begin position="394"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="192"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="192"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="221"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="249"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0799567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="558" mass="61489" checksum="71C6FF4E55312C75" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AQS2</accession>
    <name>A0A5N4AQS2_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SSD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_07526</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the patched family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AQS2"/>
    <dbReference type="InParanoid" id="A0A5N4AQS2"/>
    <dbReference type="OrthoDB" id="6510177at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1640.10">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053958">
        <property type="entry name" value="HMGCR/SNAP/NPC1-like_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051697">
        <property type="entry name" value="Patched_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796:SF130">
        <property type="entry name" value="PATCHED DOMAIN-CONTAINING PROTEIN 3-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796">
        <property type="entry name" value="PATCHED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12349">
        <property type="entry name" value="Sterol-sensing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="321"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="351"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="424"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="456"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="522"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="748"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="831"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="869"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="3">
        <location>
            <begin position="320"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0799646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="910" mass="102747" checksum="D52D51A75283C3B1" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AR36</accession>
    <name>A0A5N4AR36_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Aurora kinase</fullName>
            <ecNumber evidence="14">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PPYR_07670</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">1611_PpyrPB1</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Midbody</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="14"/>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AR36"/>
    <dbReference type="FunCoup" id="A0A5N4AR36">
        <property type="interactions" value="39"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AR36"/>
    <dbReference type="OrthoDB" id="377346at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030261">
        <property type="term" value="P:chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032506">
        <property type="term" value="P:cytokinetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14007">
        <property type="entry name" value="STKc_Aurora"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000235">
        <property type="entry name" value="Serine/threonine-protein kinase ark1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030616">
        <property type="entry name" value="Aur-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24350">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE IAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 10 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 13" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="38"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 12">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="116"/>
            <end position="118"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="165"/>
            <end position="166"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)" evidence="11">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAB0799790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="296" mass="34256" checksum="2A0FCEA089A823AA" modified="2020-02-26" version="1">MNEEPSTNYDEGTQLMLSNILSHPAYKNSSYKWSLDDFELGTRLGRGKFGRVYFAREKRSGWVVALKTLLKKEIVKGHVERQILREIEIQSNLKHPNILKLHVWFHDDHRIYLALEFAGKGEVYKQLTTIGRFSEQRTAKYIYQVADALDYCHRKKVIHRDLKPENLLLSINDDIKLGDFGWSVHAPSLSRKTMCGTLDYLPPEIVEGKQYGKYVDNWCLGILCYEFLVGHPPFESKTTEETYARITNIEISFPMHISPGGVDLISKLLLKSSVNRITLPGVMKHPWIINNYKDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ARL4</accession>
    <name>A0A5N4ARL4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PPYR_07847</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">1611_PpyrPB1</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ARL4"/>
    <dbReference type="InParanoid" id="A0A5N4ARL4"/>
    <dbReference type="OrthoDB" id="6286493at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005721">
        <property type="term" value="C:pericentric heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11726">
        <property type="entry name" value="ADDz_ATRX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025766">
        <property type="entry name" value="ADD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041430">
        <property type="entry name" value="ADD_ATRX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052131">
        <property type="entry name" value="ATRX_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46357">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR ATRX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46357:SF1">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR ATRX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17981">
        <property type="entry name" value="ADD_ATRX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51533">
        <property type="entry name" value="ADD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="15">
        <location>
            <begin position="96"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="539"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="717"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="554"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="565"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="594"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="736"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="754"/>
            <end position="769"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAB0799967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="769" mass="85395" checksum="1D3130527685D8E5" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-06-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ARL8</accession>
    <name>A0A5N4ARL8_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_07738</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ARL8"/>
    <dbReference type="InParanoid" id="A0A5N4ARL8"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0799858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="108" mass="12612" checksum="ADAAC84F659CE6DE" modified="2020-02-26" version="1">MGGPSLVEVFYEDVWITCNSLLVLMEYEVANVPWSVNDRLLGGVFFWNAWIGFKRVGFHHGFVQQEFRKFRFASHEPVHLFDFVIQLLPFRLDRGRTDFSALGKSNLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ARN8</accession>
    <name>A0A5N4ARN8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Complex I-39kD</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">NADH-ubiquinone oxidoreductase 39 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_06823</name>
        <name evidence="8" type="ORF">PPYR_07895</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="5">Complex I is composed of 45 different subunits. This a component of the hydrophobic protein fraction. Interacts with BLOC1S1. Interacts with SLC2A4. Interacts with CLOCK. Interacts with RAB5IF.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I NDUFA9 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0798943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0800015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ARN8"/>
    <dbReference type="FunCoup" id="A0A5N4ARN8">
        <property type="interactions" value="1641"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4ARN8"/>
    <dbReference type="OrthoDB" id="275457at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05271">
        <property type="entry name" value="NDUFA9_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051207">
        <property type="entry name" value="ComplexI_NDUFA9_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126:SF11">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 39 KDA SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="6">
        <location>
            <begin position="56"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00040720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00042000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00043145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00046455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0798943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0800015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="398" mass="45611" checksum="4404EA599E130050" modified="2020-02-26" version="1">MALVLHSGANVLKKHTGIISIAYIRTANYSDFNPYNLASLKRGTGGRSSFNGIVATVFGASGFIGRYVCNRLGKIGTQLILPYRGDFYPMQRLKLVGDLGQVLFQPYHLFDEESLDKAVRYSNVVINLVGRDWETRNFSFEDVHVKGARKIAEAAQRAGVKRLIHVSSLNVSEKPKAHVLEGGSKFLASKWRGEKAVLEAFPCATIIRPSDVYGQEDRFLRYYIHNWRRQVHYMPLWENGEKTIKQPLFVSDLAAGIVNAIKDPDSAGKIYQAVGPKRYLLSELVDWFYRVMRKDKEWGYYRYDMKYDPIFKLKVTLTQKLCPSWPVGHLHWERVERECITDTVERGVPTLEDLCVNLMPMENQIPWELKPYIYGIYHGRDLEDFAVRPEPPKVAASI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AS77</accession>
    <name>A0A5N4AS77_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Protein krueppel</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PPYR_08029</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the snail C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0800149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AS77"/>
    <dbReference type="InParanoid" id="A0A5N4AS77"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050527">
        <property type="entry name" value="Snail/Krueppel_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012934">
        <property type="entry name" value="Znf_AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388:SF54">
        <property type="entry name" value="PROTEIN ESCARGOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07776">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00868">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51915">
        <property type="entry name" value="ZAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZAD" evidence="12">
        <location>
            <begin position="9"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="171"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="259"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="287"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="314"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="342"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="370"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAB0800149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="409" mass="46888" checksum="416401E5E0FA0CC3" modified="2020-02-26" version="1">MDSERLFAQTCRICSAELENGVLVFGEEGKKLYLQAKIRKYLYIKISVDDKLPKMICESCCKKLEGIHKFATMAVKIQDKFNQLVINSSDSSFNDEYKDENKGLLHTYLTKGIKEKEEVTEMEVKVDPMLILQCSDDSSNDGASDTESLPESHASIDKLSTNCDDVDQTLYNCSFCPRCFTSEIALQSHMWNHIPQNKHIVLLNINNTDWEWQANSDEKNCNTRLMSESASSTTSDECETSENGNSETVQIDQENNFRFTCPICGKVISTKGNLKVHLETHRPKGKYGCEICGRIFKTQCNLYRHKEYHEGIQFPCVVCGRVYPTNSTLRAHSITHSDLRPHKCPLCIKTFKRNQDLKFHINQHTGARPYQCPYCPKAFASSGNCFSHRKRMHPFEVERDREKAAKIMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ASM7</accession>
    <name>A0A5N4ASM7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DDE-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_06049</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000004">
        <property type="protein sequence ID" value="KAB0800309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ASM7"/>
    <dbReference type="InParanoid" id="A0A5N4ASM7"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF74">
        <property type="entry name" value="POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE-1" evidence="2">
        <location>
            <begin position="213"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="DDE-1" evidence="2">
        <location>
            <begin position="824"/>
            <end position="918"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0800309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="919" mass="104450" checksum="A919C8845D96659E" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ASZ4</accession>
    <name>A0A5N4ASZ4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Acyltransferase 3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_06080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000004">
        <property type="protein sequence ID" value="KAB0800340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ASZ4"/>
    <dbReference type="InParanoid" id="A0A5N4ASZ4"/>
    <dbReference type="OrthoDB" id="207378at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052728">
        <property type="entry name" value="O2_lipid_transport_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161:SF69">
        <property type="entry name" value="NOSE RESISTANT TO FLUOXETINE PROTEIN 6-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161">
        <property type="entry name" value="O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="281"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="326"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="387"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="432"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="469"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="Acyltransferase 3" evidence="2">
        <location>
            <begin position="92"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0800340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="498" mass="56454" checksum="5F13ACFFA0374C8D" modified="2020-02-26" version="1">MLQDIKFHILSAVTTFVLVLILISTAVDYCLSKDKDVEVTKQYGTTADPDLSKKSVKVGIFELPKNVLLCFSAITNGRRILNVDHLNKESIACLHGLRFFSISWIILVHSYLEVFAVADNKTLRTVTERSYLYQTISNGTFSVDTFFFISGLLLTTTYLKRELKTPTESGEAQRDGIGLSVAKNILLILYRYIRLTPAYLFVLGLNELAIRYYHNFSVFSPAIIDHISCPEHWWRNALYINNFYPLTEFCMLWSWYMSNDMQFFVIAIVLLAIAARNEKCFRWIVGTVVVFLFTSWVVTFIIAMQYKYVARIEEPFALFDQLYDKPWLRIGPYLIGMATGYLLLRMKYKMVMPKVVVFGAWVLSLGCLLVLVYGLGRDGLVIPVSAFYASLGHTAWGLAIAWITIACSTGYGGPIDSVLSFRGIYPLSRLTYCAYLIHPVIMCITSFEMDGPFHLHQIIMLIVHFGNTVASFVAAFLISLGFEAPFVGLIKIMTGGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ATA0</accession>
    <name>A0A5N4ATA0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_06198</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000004">
        <property type="protein sequence ID" value="KAB0800458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ATA0"/>
    <dbReference type="FunCoup" id="A0A5N4ATA0">
        <property type="interactions" value="13"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4ATA0"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45664:SF20">
        <property type="entry name" value="AGAP001560-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45664">
        <property type="entry name" value="PROTEIN ZERKNUELLT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="146"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="148"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="96"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="96"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="121"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0800458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="257" mass="29064" checksum="8E39BD15D5893E20" modified="2020-02-26" version="1">MSRSFLVDSLISNTPKDFSANNKHYISEPTRPALPYPSSYISSYLFSLSLAQQHHHMHLNNGLVSPPFGHHKTPIRPIASVPRGSQESVIRQCSISPQRYSDVPQSRKLSSPCASPHVSPTEVSESRQSTPSPPPDNHDYNSKESSSTKRIRTAFTSTQLLELEREFASNMYLSRLRRIEIATCLRLSEKQVKIWFQNRRVKYKKEELPGMVNGTPPTPKCFCLRTCSSTRKSKNSGSTCSDMDIDVMHTDDELVHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ATX5</accession>
    <name>A0A5N4ATX5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_06409</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000004">
        <property type="protein sequence ID" value="KAB0800670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ATX5"/>
    <dbReference type="InParanoid" id="A0A5N4ATX5"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF220">
        <property type="entry name" value="PROTEIN ALP1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="8">
        <location>
            <begin position="29"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0800670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="261" mass="29074" checksum="CAD51AEB5F829175" modified="2020-02-26" version="1">MPQPTKGILISCAEKFESIWNFPNCVAAIDGKHITIQAPAGSGSLSFNYKKTFSIVLLAMVDPEYRFIAVDVGGYGKNSDGGLFNNSRMGKALQNNTFGIPEDRPITENGKPLPFVIVGDEAFPSKTYLMRPYPGRGLSEDKKIFNYRLSRARRVSENAFGILCQKFRVFLNKIQVHPNNVDKIVLSSLCLHNFLRSDNVFLNALDEENSEKERPIFINLPHIGGKSSTDAIEVREDFTKYFTSAAGTVPWQMDTVNAGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ATX8</accession>
    <name>A0A5N4ATX8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transforming acidic coiled-coil-containing protein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_06533</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TACC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000004">
        <property type="protein sequence ID" value="KAB0800794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ATX8"/>
    <dbReference type="InParanoid" id="A0A5N4ATX8"/>
    <dbReference type="OrthoDB" id="10255048at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039915">
        <property type="entry name" value="TACC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007707">
        <property type="entry name" value="TACC_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13924">
        <property type="entry name" value="TRANSFORMING ACIDIC COILED-COIL CONTAINING PROTEIN 1/2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13924:SF10">
        <property type="entry name" value="TRANSFORMING ACIDIC COILED-COIL PROTEIN, ISOFORM K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05010">
        <property type="entry name" value="TACC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transforming acidic coiled-coil-containing protein C-terminal" evidence="8">
        <location>
            <begin position="36"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="182"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0800794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="227" mass="26248" checksum="DD600843A347AAF8" modified="2020-02-26" version="1">MSIIRIIQESDLMNNRSMFSLKTVNTELGKMDEIIKEKDVIIQNNCERIQEMEAHIVELEGSLQKSLREKRDDEILVKYNKFIHDIMTKHETVMAQRNVICDHLACLETGFADLVTKYERLKTILAGYQANQAVLVDRVTEQVGNIEVLQQRYDKLKSHTNDKLREANAHVANMHRKHAEEIASVKIQLQGQKDKITELEQSLADCRGEAPVKKKLLPSIINTFKFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AU44</accession>
    <name>A0A5N4AU44_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_06578</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000004">
        <property type="protein sequence ID" value="KAB0800839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AU44"/>
    <dbReference type="InParanoid" id="A0A5N4AU44"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF269">
        <property type="entry name" value="NUCLEASE HARBI1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="8">
        <location>
            <begin position="63"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0800839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="285" mass="32439" checksum="F13C066F98AFB335" modified="2020-02-26" version="1">MKDLHIDYRIGLSSISNIIREVCASLWSRLKSACFPPLTKEFLAKSAEEFEARANFPNCVAAIDGKHIRMIKPAKSGSMNFNYKHYFSVLLLAACDSQYKFLYINVGAPGKSSDSTIFKNSKLYSQLKSGQIKMPPPRTISESRPTTVPYFLIGDEGFGLCDFLIRPFAGKYLPIGKKIFNYRLTRARRYIECTFGILSNKWRIFHRPLNVDEDLTDSIVKTCCLHNFVRERDGYQLEDTITVEGLVDNMAPDNSQPGNADKSVPTVLTDYFLNEGQLQWQMDKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AUW9</accession>
    <name>A0A5N4AUW9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Trafficking protein particle complex subunit 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_05463</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000003">
        <property type="protein sequence ID" value="KAB0801109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A5N4AUW9">
        <property type="interactions" value="2165"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AUW9"/>
    <dbReference type="OrthoDB" id="203724at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990072">
        <property type="term" value="C:TRAPPIII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058541">
        <property type="entry name" value="Ig_TPPC8_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058538">
        <property type="entry name" value="Ig_TPPC8_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057651">
        <property type="entry name" value="Ig_TPPC8_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024420">
        <property type="entry name" value="TRAPP_III_complex_Trs85"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12975:SF6">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12975">
        <property type="entry name" value="TRANSPORT PROTEIN TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24545">
        <property type="entry name" value="Ig_TPPC8_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24544">
        <property type="entry name" value="Ig_TPPC8_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24542">
        <property type="entry name" value="Ig_TPPC8_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12739">
        <property type="entry name" value="TRAPPC-Trs85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TPPC8 first Ig-like" evidence="3">
        <location>
            <begin position="681"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="domain" description="TPPC8 second Ig-like" evidence="2">
        <location>
            <begin position="877"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="domain" description="TPPC8 C-terminal Ig-like" evidence="1">
        <location>
            <begin position="1217"/>
            <end position="1315"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0801109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1347" mass="151934" checksum="7444E48BD88E1B46" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-09-13" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AWL7</accession>
    <name>A0A5N4AWL7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tyr recombinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_03917</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0801731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AWL7"/>
    <dbReference type="InParanoid" id="A0A5N4AWL7"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="entry name" value="Intergrase catalytic core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0801731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="296" mass="34026" checksum="1A4A6404C750B34A" modified="2020-02-26" version="1">MIKNILTVKENENASKLCKTIDFLKRQTLRYIPKKSKVLIRKFGARCRGDDTIRSTIDDVLKIIGGLRPKKRSIICYRQNQKENWCGAQNVTVISENVLLAFFTIMSKSYKSSTLWKNYSMLRSMLNVRENIDISKFMKLQALLRRTSVGYEAKKSKILEYPEIERFINEAPNTEYLAAKVILIIGYSGACRREELKNLLTDDIDYKSDSIFVTPFHKATAQTLSRWIKIILQKSGVDVTKFSAYSTRHAATSAASRKGLNLILFGYRRVGPRIPICLLRCTIDLYVRTNLSLKQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AWS2</accession>
    <name>A0A5N4AWS2_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Core Histone H2A/H2B/H3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PPYR_03970</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the histone H3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0801784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AWS2"/>
    <dbReference type="InParanoid" id="A0A5N4AWS2"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005700">
        <property type="term" value="C:polytene chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22911">
        <property type="entry name" value="HFD_H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000078">
        <property type="entry name" value="Histone H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000044">
        <property type="entry name" value="Histone H3.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11426">
        <property type="entry name" value="HISTONE H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00622">
        <property type="entry name" value="HISTONEH3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00428">
        <property type="entry name" value="H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00322">
        <property type="entry name" value="HISTONE_H3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00959">
        <property type="entry name" value="HISTONE_H3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="9" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="11">
        <location>
            <begin position="358"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="321"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="28"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="76"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="101"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="190"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="239"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="336"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAB0801784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="450" mass="48614" checksum="56811A700E5BA287" modified="2020-02-26" version="1">MRGAVIKCRAKIASPPPPREFSADTGRVTITSALQSPTSRVSSRNQSCRSDTTRSGSPLQEAARSQPQAEERKTATVANNSPTPAATMNSNNPYRTNATIPASTMKPASTTPSTPTAPRASTIPPASTSPPTPTTLAAAPLPDEDNAVAMDLAEIPPPPPPATPAIKRSKRQKETHRTESESNPSETDCAGPASYAGAASAKNANTRRTDPAPFRPQPPAPTSDTASSSEDERWEKATTRKKRRNATRKHNGVKPQDTVLQLNETVTGETARPATATAREHIRKPAAKPCTSRLSLVASHYFPSFAVSVLLLSAMARTKQTARKSTGGKAPRKQLATKAARKSATATGGVKKPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEASEAYLVGLFEDNNLCAIHAKRVTIMPKDIQLARRIRGERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AX25</accession>
    <name>A0A5N4AX25_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">Nicotinic acetylcholine receptor alpha 8 subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">PPYR_04053</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">1611_PpyrPB1</strain>
            <tissue evidence="21">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="17">Postsynaptic cell membrane</location>
            <topology evidence="17">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0801867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AX25"/>
    <dbReference type="FunCoup" id="A0A5N4AX25">
        <property type="interactions" value="40"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AX25"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022848">
        <property type="term" value="F:acetylcholine-gated monoatomic cation-selective channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007271">
        <property type="term" value="P:synaptic transmission, cholinergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19064">
        <property type="entry name" value="LGIC_TM_nAChR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000013">
        <property type="entry name" value="Acetylcholine receptor subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000030">
        <property type="entry name" value="Acetylcholine receptor subunit alpha-L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000012">
        <property type="entry name" value="Acetylcholine receptor subunit alpha-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002394">
        <property type="entry name" value="Nicotinic_acetylcholine_rcpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00860">
        <property type="entry name" value="LIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00254">
        <property type="entry name" value="NICOTINICR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="16 18" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9 18" id="KW-0406">Ion transport</keyword>
    <keyword evidence="15" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="10 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0770">Synapse</keyword>
    <keyword evidence="5 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 18" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="169"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="398"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="19">
        <location>
            <begin position="3"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="20">
        <location>
            <begin position="175"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAB0801867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="23">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="452" mass="51689" checksum="3C6F38F0F2631DBC" modified="2020-02-26" version="1">MFLYLFQKWVDYKLRWDPEEYGGVEQLYVPSEHIWLPDIVLFNNADGNYEVTLMTKAVLSYTGEVVWKPPSIYKSSCEINVQYFPFDEQSCLMKFGSWTYNGYQVDLKHMDQVPGSNIVKVGIDLSEFYLSVEWDLLAVPATRNEEYYPCCSEPYSDITFKITMRRKTLFYTVNLIIPCVGITFLTVLVFYLPSDSGEKVTLCVSILISLTVFFLLLAEIIPPTSLAVPLLGKYLLYTMIIVTSSIWVTVCVLNVHFRSPSTHKMSPWVRKLFLQFMPRLLIMRRTTYVLPEYNDNVPPRGFSATDMDIQLNMGEPFTTDFKISTSDPSFLLPDHDDGKMKAHSSMTDTSNGTPKTLSAGVLSALQGVRFIAQHIRDADKDNEVVEDWKFVSMVLDRFFLWLYTLACIGGTAGIIMQAPSLYDTRTPVDQELSEITMDKIFQKLPPSHVPMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-06-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AX32</accession>
    <name>A0A5N4AX32_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_04111</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0801925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AX32"/>
    <dbReference type="InParanoid" id="A0A5N4AX32"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024313598" evidence="1">
        <location>
            <begin position="22"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0801925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="289" mass="33652" checksum="0EF2708523642045" modified="2020-02-26" version="1">MYLIMWMLFLWALSVIGDSWCVLTEDASTIEFLGDRVVARNNEKISQSYGRGSGNNLGAEYPDDRISEYSSRCSERLENALEKIRRRELSKQKSVKLHGYSLHHQMRSAPYDMYVTEMRVRIPSTVSWVRVDKCRFDPRNSSLETRLLFNDLTISGKVNLFNDGELQREPVNPSPEDSCNMILRLRRAGIGFNTEPIRSERGQFNVRTDSYFVEPGFISVYAYGCEPRLKQHRRSYRDDDEEEDDISREMEDIFLKGIRSLLTNYMQKELQPAIKETLMTNLGYTVSYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AXC9</accession>
    <name>A0A5N4AXC9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Spaetzle domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_04208</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AXC9"/>
    <dbReference type="InParanoid" id="A0A5N4AXC9"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005121">
        <property type="term" value="F:Toll binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021556">
        <property type="term" value="P:central nervous system formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032104">
        <property type="entry name" value="Spaetzle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052444">
        <property type="entry name" value="Spz/Toll_ligand-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23199">
        <property type="entry name" value="NEUROTROPHIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23199:SF12">
        <property type="entry name" value="NEUROTROPHIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16077">
        <property type="entry name" value="Spaetzle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50270">
        <property type="entry name" value="NGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Spaetzle" evidence="4">
        <location>
            <begin position="44"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0802022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="177" mass="20884" checksum="9780EBC005E2FBF1" modified="2020-02-26" version="1">MQEFWYDPYYKHEISLPNAGKLLSPRENQELLRNETQLRSAVDCCPSVLEMVEPEGGKNQDDQYVELYRDGENRQRFYELSCHKDIVGRPCRFIDRKLHIQSKCIQKYSYTYALVKDPGRHQHQRPNYFPAFPLTDGATFTLDYIRVRSGCSCVVTPNAKKKREKKAKRRVEKDESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AYX8</accession>
    <name>A0A5N4AYX8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CHK kinase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_04720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AYX8"/>
    <dbReference type="InParanoid" id="A0A5N4AYX8"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015897">
        <property type="entry name" value="CHK_kinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004119">
        <property type="entry name" value="EcKL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012">
        <property type="entry name" value="PROTEIN KINASE-LIKE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012:SF30">
        <property type="entry name" value="PROTEIN KINASE-LIKE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02958">
        <property type="entry name" value="EcKL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00587">
        <property type="entry name" value="CHK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHK kinase-like" evidence="1">
        <location>
            <begin position="114"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="CHK kinase-like" evidence="1">
        <location>
            <begin position="499"/>
            <end position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0802534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="782" mass="91214" checksum="C29C4AE944F27A63" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AZ12</accession>
    <name>A0A5N4AZ12_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_04709</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AZ12"/>
    <dbReference type="FunCoup" id="A0A5N4AZ12">
        <property type="interactions" value="22"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AZ12"/>
    <dbReference type="OrthoDB" id="8197488at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043407">
        <property type="entry name" value="Nkap_D1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46940:SF1">
        <property type="entry name" value="NKAP DOMAIN CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46940">
        <property type="entry name" value="NKAP DOMAIN-CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15692">
        <property type="entry name" value="NKAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="90"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="148"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="329"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0802523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="495" mass="56446" checksum="D8843D7AE7C9F574" modified="2020-02-26" version="1">MSTRKRSKSRERREDSKSSKLRMDSKAPIPRITDPSLPAGRRREIDTVMKKARASAHANEYWDKKILEVEAKDPNRWRHSGYKSLYLDGSSSPSPSRRSRSRSPVGRRSPRSPPSRRSPIGRRSPRSPPLRRSPVGRRSPRSPPSRRSPPVTRRSPLPPARSGKSVRPRSPRSPPIHKGRRSPSGSSVSSCSDDSCSVCSPKNNRRARSRSRSLSVSRSRKPHVKHGSPKIRARPRPPSPSPIPRRVPRPMTPPPVRRPVKGLISDKPTDPRRQPPPPRPRNPSGKVINLGSIAPPAAVKKTIRKKEKFTEPVLLTRIKKERTKKRPGSPDSSGSEDSSTSSLSPIVATTRLSLSERFGKMAQWSIDRERRDIENMRITKNSSGGDLKVMIEEDDFLYGSPPRRYSHSPVPPGHYPDELLSAGPSGLASWDDVRVRYQYYKDLGYLRDLSLDDYVKWEEWWYKYQDWLANERHYEHWLSTQRRGKKRLPASQRLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-06-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AZP4</accession>
    <name>A0A5N4AZP4_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_05017</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AZP4"/>
    <dbReference type="InParanoid" id="A0A5N4AZP4"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0802831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="122" mass="13490" checksum="91447ED6F5F2DE3A" modified="2020-02-26" version="1">MGGVVPLVSVDFEVFGRVQGTVWLLLSSVCNVYIQQGYTLRSTVENLQNNWVLLDGLKTLERVQLLVLRKDINPILKQCKCQVINRHLAYFQIEVFVNSAGSTNVSVSGLTGCPISDPPVVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B188</accession>
    <name>A0A5N4B188_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cystathionine beta-synthase</fullName>
            <ecNumber evidence="4">4.2.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PPYR_00325</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-homocysteine + L-serine = L,L-cystathionine + H2O</text>
            <dbReference type="Rhea" id="RHEA:10112"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:58161"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="4.2.1.22"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-homocysteine and L-serine: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cysteine synthase/cystathionine beta-synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.22" evidence="4"/>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B188"/>
    <dbReference type="InParanoid" id="A0A5N4B188"/>
    <dbReference type="OrthoDB" id="728at2759"/>
    <dbReference type="UniPathway" id="UPA00136">
        <property type="reaction ID" value="UER00201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004122">
        <property type="term" value="F:cystathionine beta-synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019343">
        <property type="term" value="P:cysteine biosynthetic process via cystathionine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01561">
        <property type="entry name" value="CBS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000003">
        <property type="entry name" value="Cystathionine beta-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000118">
        <property type="entry name" value="Related to CYS4-cystathionine beta-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050214">
        <property type="entry name" value="Cys_Synth/Cystath_Beta-Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005857">
        <property type="entry name" value="Cysta_beta_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01137">
        <property type="entry name" value="cysta_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10314">
        <property type="entry name" value="CYSTATHIONINE BETA-SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0129">CBS domain</keyword>
    <keyword evidence="7" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="11">
        <location>
            <begin position="39"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAB0803355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="497" mass="54988" checksum="DEAAEC999D6B46D9" modified="2020-02-26" version="1">MEFLKPGEVSQCLYNQNDKQSPHPKLNKKPFQKIIPNILHAIGNTPMIRLNHIPQSFGIKCEIFAKCEFFNPGGSVKDRIAIAMIEDAESRGLLKSTSTIIEPTSGNAGIGLAVACAVKGYKCICVMPDKTSMEKENILTSLGAKVIRTPDTSVDDPDGVFHISRKLAASIPDSIILQQFKNPINPLAHYHITAMEIFDQCDGEIDMIVIGVGSGGTMTGVGRKIKELLPNCTIVGVDPVGSFIAEPPILNETTLKYTEVEGIGHDYYPKTLDKSVVDYWIKVTDKESLHMARKLHREEGILCGSSTGSLMSGALEAARNLKEGQKCVVMFPDGVGNYLTKFVSDYWMESKDFLPRPNIFKHWWWDITVSNLSLARTETISLNMTCGELSSMLYSQGVDVLPCVDQNRILQGIIYAKDVTCKLLNASITLGDPVRRVLSQKYRKITVNSSLGELSHILERELVAVIVEENEPSQPIIFKGFVFASNLVQYITENSIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B1H0</accession>
    <name>A0A5N4B1H0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Metaxin glutathione S-transferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PPYR_00417</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B1H0"/>
    <dbReference type="FunCoup" id="A0A5N4B1H0">
        <property type="interactions" value="1490"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4B1H0"/>
    <dbReference type="OrthoDB" id="5835136at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001401">
        <property type="term" value="C:SAM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033468">
        <property type="entry name" value="Metaxin_GST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050931">
        <property type="entry name" value="Mito_Protein_Transport_Metaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019564">
        <property type="entry name" value="Sam37/metaxin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289:SF41">
        <property type="entry name" value="FAILED AXON CONNECTIONS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289">
        <property type="entry name" value="METAXIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17171">
        <property type="entry name" value="GST_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10568">
        <property type="entry name" value="Tom37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Mitochondrial outer membrane transport complex Sam37/metaxin N-terminal" evidence="8">
        <location>
            <begin position="36"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Metaxin glutathione S-transferase" evidence="9">
        <location>
            <begin position="184"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0803447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="299" mass="35349" checksum="91537D6CBFFBE81F" modified="2020-02-26" version="1">MYLGNDPEYPTSYTRPPITIRVWPGDYGAPSVDPTSLIVLTVCKMHKVPVKIVPAFFPFLVDIPSIEERNLLIVDKEKILDYVFQLCHEESLLNARQRRKLRAYKQYFMQHFGGPFYFDCWIHETNFTHAIETWFTRVIPFPFNLLYLHQKRKLAQNEFNLVKRTSEADTFMSSKYEGAAVCLGDFDYLLKDDRKFLYKNIPTSLDAIVYSYLVIAMNMPLQNPKLQQFIYRHKWLVNYVHRITKEYFPNTSYQFQYVDPVYAPYDRVSTKCLIIFGMCVTILMALYAHTNGIFKLKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B1V1</accession>
    <name>A0A5N4B1V1_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_00340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B1V1"/>
    <dbReference type="InParanoid" id="A0A5N4B1V1"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33053">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33053:SF26">
        <property type="entry name" value="TRANSPOSASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0803370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="96" mass="10701" checksum="2AA8B38A587454E6" modified="2020-02-26" version="1" fragment="single">MYTIQVHSFICDSPARAYVQCIKSHGGYSSCERCMEPGINANKRTDQSFVLQSDEDHHIGESPLLTLPIGLVSRFGIDYMHCICLGVICENCLYLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B5V8</accession>
    <name>A0A5N4B5V8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Guanine deaminase</fullName>
            <shortName evidence="9">Guanase</shortName>
            <ecNumber evidence="3 9">3.5.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Guanine aminohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PPYR_01710</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>guanine + H2O + H(+) = xanthine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:14665"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16235"/>
            <dbReference type="ChEBI" id="CHEBI:17712"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Purine metabolism; guanine degradation; xanthine from guanine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.3" evidence="3 9"/>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B5V8"/>
    <dbReference type="FunCoup" id="A0A5N4B5V8">
        <property type="interactions" value="442"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4B5V8"/>
    <dbReference type="UniPathway" id="UPA00603">
        <property type="reaction ID" value="UER00660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008892">
        <property type="term" value="F:guanine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006147">
        <property type="term" value="P:guanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000022">
        <property type="entry name" value="Guanine deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014311">
        <property type="entry name" value="Guanine_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051607">
        <property type="entry name" value="Metallo-dep_hydrolases"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02967">
        <property type="entry name" value="guan_deamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11271">
        <property type="entry name" value="GUANINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11271:SF6">
        <property type="entry name" value="GUANINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="10">
        <location>
            <begin position="64"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0804740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="432" mass="47759" checksum="66A5D67F3422036E" modified="2020-02-26" version="1">MESIVDLFIGNIIHCDQPFTVTVIQKGFVAVQRNKIIAVGHSSELQNRFTSENVRKTLLSDSQILIPGLIDTHIHACQYPNIGVGMNKPLLQWLKDHTYPLEKKFKDAQFSKRCYDAVVKKTLSYGTTTAAYFGSIYTDSTLILADSAIRLGQRALVGKVNLTKNGPADYIETSEESLRETRRFINEMSKKNSELVKPIITPRFAVSVTKEDLKALGEMAKEFNLPIQAHMNETIDGIKQLESRPGDVHKNFTHTHEILTEKSLFAHCVHMTKEEIQKLADSGSAIAHCPDSNFNLLSGICDVRAFIEAGVKVGLGTDVSAGCSLSIMNAMRYAITASTALSFSKKGYKPLNYFDAFYLATLGGAKALSMDDKIGNFEVGKEFDALIVDLDVQNGPVDIFGEHTALELFQKFIFTGDDRNVTAVYVAGNKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B606</accession>
    <name>A0A5N4B606_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glycosyltransferase family 92 protein</fullName>
            <ecNumber evidence="8">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_02009</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyltransferase 92 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="8"/>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0805039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B606"/>
    <dbReference type="FunCoup" id="A0A5N4B606">
        <property type="interactions" value="110"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4B606"/>
    <dbReference type="OrthoDB" id="2017643at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008166">
        <property type="entry name" value="Glyco_transf_92"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21461">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21461:SF83">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01697">
        <property type="entry name" value="Glyco_transf_92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0805039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="558" mass="65220" checksum="3344F74E1690DE26" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B620</accession>
    <name>A0A5N4B620_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phenoloxidase-activating factor 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Prophenoloxidase-activating factor II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_01976</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0805006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B620"/>
    <dbReference type="FunCoup" id="A0A5N4B620">
        <property type="interactions" value="55"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4B620"/>
    <dbReference type="OrthoDB" id="6261922at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000038">
        <property type="entry name" value="Serine protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041515">
        <property type="entry name" value="PPAF-2-like_Clip"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051487">
        <property type="entry name" value="Ser/Thr_Proteases_Immune/Dev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24256">
        <property type="entry name" value="TRYPTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18322">
        <property type="entry name" value="CLIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024353753" description="Phenoloxidase-activating factor 2" evidence="7">
        <location>
            <begin position="21"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="8">
        <location>
            <begin position="111"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00068096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00076468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0805006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="377" mass="42390" checksum="135F1553B884D1D4" modified="2020-02-26" version="1">MWFMCLLILFLISGLDTSESSDSSEIIFLENENDKMFIRSADCVCVPYFKCKEVVEDGVGVINIRTANPCNTLEVCCGAGNTTTESIIPKTRWTGQRPCGIRNKEGFGLRITGIEDNETQFGEFPWMVALFRTSTNKRTMEKTETYHCGASLIHPQVVLTAAHCVSDKAYKYRIRAGEWDTHTTNELFPHQEREVKETIIHPQYYKGGFFYDFALLILDSPLEISENVDVVCLPDKTMIPQQVFCSATGWGQEVFSEEGKNPAILKKIDLPIVDRDNCQKRLRNTRLGAQFKLHETFICAGGELGKGACKGDGGSPLVCPVDDETDRFYQAGIVAWGIDCGKEDVPGAYADVAKAMDWIDDVMTRHTFDRSIYRYGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B647</accession>
    <name>A0A5N4B647_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Iron-sulfur cluster assembly 2 homolog, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">HESB-like domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PPYR_01998</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in the maturation of mitochondrial 4Fe-4S proteins functioning late in the iron-sulfur cluster assembly pathway. May be involved in the binding of an intermediate of Fe/S cluster assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterotetramer; forms a dimer of dimers with IBA57. Interacts with [2Fe-2S]-ISCA2 forming the heterodimer [2Fe- 2S]-ISCA2-IBA57 complex; [2Fe-2S] cluster binding is absolutely required to promote the complex formation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HesB/IscA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0805028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B647"/>
    <dbReference type="FunCoup" id="A0A5N4B647">
        <property type="interactions" value="1012"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4B647"/>
    <dbReference type="OrthoDB" id="1938621at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120510">
        <property type="term" value="C:mitochondrial [4Fe-4S] assembly complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.300.12:FF:000006">
        <property type="entry name" value="Iron-sulfur cluster assembly 2 mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.300.12">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016092">
        <property type="entry name" value="ATAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000361">
        <property type="entry name" value="ATAP_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035903">
        <property type="entry name" value="HesB-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00049">
        <property type="entry name" value="iron-sulfur cluster assembly accessory protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43011">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY 2 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43011:SF1">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY 2 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01521">
        <property type="entry name" value="Fe-S_biosyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89360">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core" evidence="10">
        <location>
            <begin position="37"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00057540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00073313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00077082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00093471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0805028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="144" mass="15939" checksum="8692B3FC61906BD0" modified="2020-02-26" version="1">MALLNICRTSFKSLPKPFFLNNYSQTGPQPLKNVKAELIISDKCIARLNDVAKDTNEFLRVSVEGGGCSGFQYKFELDSHLTDDDRVFSRDGAKVVIDKTSLEYVKGATVDYTEELIRSSFKIVSNPLAEQGCSCGASFAIRLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B7R9</accession>
    <name>A0A5N4B7R9_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_02619</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0805649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B7R9"/>
    <dbReference type="InParanoid" id="A0A5N4B7R9"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF5">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0805649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="197" mass="22615" checksum="E97530A5F2F1A5BF" modified="2020-02-26" version="1">MAQRQVYFDEVTTLINGKKLKNNSNLVNLNPFLDEDGVLRVRSRLSNARHMKFNAKFPIILPKQHHITKLIVTYQHRMLLHAGVQATLYALRQNYWVPGGKSVIIVYTCFDIVASIVIFQRAGVCTNKLYLRWVTAGEKEQVAAELFYPKESQSKIRCSQANILINEPPIKSILLIATNNMFSFKKGTPCPFKQYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B7W3</accession>
    <name>A0A5N4B7W3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Luciferin 4-monooxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_02593</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0805623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B7W3"/>
    <dbReference type="InParanoid" id="A0A5N4B7W3"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05911">
        <property type="entry name" value="Firefly_Luc_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000007">
        <property type="entry name" value="4-coumarate--CoA ligase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.38.10">
        <property type="entry name" value="Luciferase, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF149">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="5">
        <location>
            <begin position="20"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="6">
        <location>
            <begin position="360"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0805623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="452" mass="49988" checksum="5BF61EC3D5226290" modified="2020-02-26" version="1" fragment="single">HAFGIGYFYATQQFCTTMLSGELIHVANISQPSIIFCSTEASSVILKVKDRLKRVPKLVVINAKEDYRGCQSMKSFISEYIPANFDVSTFSPCPVNVKEDVAFILQSSGTTGLPKGVMLTHFNYTTVIGVIGFAAITNPRAAVTLINLPLHHAYGLFLAFRGIFDGGKAIIMKKFDPDVYLKTIQDYKIDQLSIVPSMANFLIKSPLVDKYDLSSVKRIRCGAAPLGKSAEEALIKRLKVDDIRQGYGMTEATIGILVSLDDQVVPGSCGIPFPNMAIKIVDVDTGKSLGPMAVGEIWCRGDIIMKGYFNDPEATRNTIDEDGWLHTGDMAYYDNNHMFFIVDRLKELIKCKGYQVAPAELEAILVNHPKVADVGVIGIPHDRHGEVPIAFVVAMQGQDLTEKELKDFIHGQVAAYKRLESVLFVPNIPRNPAGKIIRRILRDTLHKHNSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B800</accession>
    <name>A0A5N4B800_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_02654</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0805684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B800"/>
    <dbReference type="InParanoid" id="A0A5N4B800"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0805684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="172" mass="19205" checksum="023BD4324C78507B" modified="2020-02-26" version="1">MLYSDRGSNFVGAKSQLKDLFELIRSENFKTQIEAELTIKGIQWNFIAPGAPHMGGLWESNIKSVKSHLLKIVGDQLLTYEELNTLLIQIECLLNSRPLCVLSSDPAEPIALTPAHFLTLTPLDRLPAINVMDVNLSRLSRYQLIDQWCNTFGNAGALSTYIPCKHVKSGIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1JUB4</accession>
    <name>A0A1Y1JUB4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">E3 ubiquitin-protein ligase APD1-4 middle domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_10679</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01100402">
        <property type="protein sequence ID" value="JAV52892.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1JUB4"/>
    <dbReference type="InParanoid" id="A0A1Y1JUB4"/>
    <dbReference type="OrthoDB" id="6435218at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032010">
        <property type="entry name" value="APD1-4_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032008">
        <property type="entry name" value="APD1-4_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39077">
        <property type="entry name" value="DUF4793 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39077:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE APD1-4 MIDDLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16041">
        <property type="entry name" value="APD1-4_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16040">
        <property type="entry name" value="APD1-4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="420"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="E3 ubiquitin-protein ligase APD1-4 N-terminal" evidence="2">
        <location>
            <begin position="93"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="E3 ubiquitin-protein ligase APD1-4 middle" evidence="3">
        <location>
            <begin position="330"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="JAV52892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0796618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="440" mass="49613" checksum="4925E1BD6D48E270" modified="2017-08-30" version="1">MKPSAGENVIYYNGVRYSSITNLGKIGSMHGVKRVVVFCIMTTVLPAALIITPLYLRHVVFADVPYALTESDVVEIKNGISSIFCAAHSLQMNATFNAIQLHKSPILSDQRKHIRLRKAMSLPDDTLEYWGFYLLKGATVNLKVCSRYDGARILVVRGEKNLQTCGLMERNFSKIGATMHREYKQVKVTFESAEDAKDHILTEPPLMDGGEIVDDFHPHSEDLLLDKTKHHSSKITKDELQHDLLVDDDKDKVNRVKRDTGHLLDTKIEHGGNALNFTDSSSEETSASSFETSLLDCYNGQILLTEAFPPSHLCTGTHYLENGERMETIHSIVSDGYYYYIFYSDNDREVNDIYGVFDIHKPTLLVPTGSEAKTCNNITECVFPMEFWTDETVIVEVPTKEGIVYQQNDTILISTCQPRMSIYIIFPVAIMFLILACAFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1K3Z4</accession>
    <name>A0A1Y1K3Z4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable RNA polymerase II nuclear localization protein SLC7A6OS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PPYR_01264</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Directs RNA polymerase II nuclear import.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the IWR1/SLC7A6OS family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01093679">
        <property type="protein sequence ID" value="JAV56199.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1K3Z4"/>
    <dbReference type="FunCoup" id="A0A1Y1K3Z4">
        <property type="interactions" value="1260"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1K3Z4"/>
    <dbReference type="OrthoDB" id="6255506at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040218">
        <property type="entry name" value="SLC7A6OS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013883">
        <property type="entry name" value="TF_Iwr1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31196">
        <property type="entry name" value="RNA POLYMERASE II NUCLEAR LOCALIZATION PROTEIN SLC7A6OS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31196:SF2">
        <property type="entry name" value="RNA POLYMERASE II NUCLEAR LOCALIZATION PROTEIN SLC7A6OS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08574">
        <property type="entry name" value="Iwr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Transcription factor Iwr1" evidence="11">
        <location>
            <begin position="133"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="176"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="JAV56199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAB0804294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="248" mass="28593" checksum="9768002452AA4DFC" modified="2017-08-30" version="1">MTAIIRIKRNCTDDPLDAVVINCKKRKLDENAAQDEDIATVLNFAGTVNSTDDVIKHIKKLNKSEVEEQYKKHNMVDIIDKLRMEKEVTSKNSRYKVVNSHRFPNTNDTESNVNCTIVDVESEELKNAEHSNNFVYDLYYTNSDDFGEPDLNELISVYPLSEGLVYGSYRDNGYNYPDSDYSEDSNAENHWRNDYPDESDCESHDESITENDMMRNMVKVDLGDDEDLSSDNYSAEEEDYYCDESCTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1K647</accession>
    <name>A0A1Y1K647_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SGF29 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_00626</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GEZM01094117">
        <property type="protein sequence ID" value="JAV55918.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1K647"/>
    <dbReference type="FunCoup" id="A0A1Y1K647">
        <property type="interactions" value="529"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1K647"/>
    <dbReference type="OrthoDB" id="10265994at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140672">
        <property type="term" value="C:ATAC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20393">
        <property type="entry name" value="Tudor_SGF29_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20394">
        <property type="entry name" value="Tudor_SGF29_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000026">
        <property type="entry name" value="SAGA-associated factor 29 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000029">
        <property type="entry name" value="SAGA-associated factor 29 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037802">
        <property type="entry name" value="SGF29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010750">
        <property type="entry name" value="SGF29_tudor-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047288">
        <property type="entry name" value="Tudor_SGF29_rpt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047287">
        <property type="entry name" value="Tudor_SGF29_rpt2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21539">
        <property type="entry name" value="SAGA-ASSOCIATED FACTOR 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21539:SF0">
        <property type="entry name" value="SAGA-ASSOCIATED FACTOR 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07039">
        <property type="entry name" value="SGF29_Tudor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51518">
        <property type="entry name" value="SGF29_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="SGF29 C-terminal" evidence="7">
        <location>
            <begin position="144"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="62"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="JAV55918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0803656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="289" mass="33046" checksum="DC5DEA30519C09CC" modified="2017-08-30" version="1">MPFTADSIAAQQVQECLKSLYRLVHDIEKKRQQSENGINTINKFNSQDERSSFMQTDIKSVYKTAMLQAEQEEELLRKALQKISDIRNIKNERRIQARNAGNKETIRRGAWMKMLLSSAQTLPLFVSKIGEKPPPLCGAVPAEPNYFAKVGDMVAALVKVAEGDGDNWILAEVVSYNHALNKYEVDDILEEQNQKKRHVLSKKYVVPLPLMRANPETDPTALFPERTVVMALYPQTTCFYKAVVNKLPQTHTDEYELLFEDFSYTNGYSPPLYVAQRYVLAIKQKTRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1K708</accession>
    <name>A0A1Y1K708_PHOPY</name>
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            <fullName evidence="2">Myb/SANT-like DNA-binding domain-containing protein</fullName>
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        <name evidence="4" type="ORF">PPYR_01866</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01093331">
        <property type="protein sequence ID" value="JAV56281.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1K708"/>
    <dbReference type="InParanoid" id="A0A1Y1K708"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Myb_DNA-bind_4"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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            <end position="151"/>
        </location>
    </feature>
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            <begin position="179"/>
            <end position="227"/>
        </location>
    </feature>
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        <location>
            <begin position="210"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="JAV56281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0804896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="272" mass="32065" checksum="BF163348BAAD890B" modified="2017-08-30" version="1">MKMYGFWTNRYVYPYDPTASETSSYVETEEMLTQQSDEVFTEQTDICGASTSNVEDENVVPILWPVPAKKLLIELYPKFAKRFSDRLIISKEQMFAKLAAEMAQFGYKYTTTQVKYRWRCFERSYKNFIKHTKATGREYKKLEFYDELHDIFHNEPRFHPEIVTSSVITVTKEISKENVPPVEETLLPQEQHETTRNETNTADVASDKPASAKREQSTRKEGYKPTSSVLQQLHMEMKRKNNLTEKKLVIEQERNTLLERKLNLLEKYLDNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2023-09-13" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1K9J8</accession>
    <name>A0A1Y1K9J8_PHOPY</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_08292</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
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        <lineage>
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            <taxon>Coleoptera</taxon>
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            <taxon>Photinus</taxon>
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    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01091082">
        <property type="protein sequence ID" value="JAV57106.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01091081">
        <property type="protein sequence ID" value="JAV57108.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01091078">
        <property type="protein sequence ID" value="JAV57112.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01091076">
        <property type="protein sequence ID" value="JAV57115.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1K9J8"/>
    <dbReference type="InParanoid" id="A0A1Y1K9J8"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="JAV57108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0797298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="101" mass="11576" checksum="617CCE9876AF6B92" modified="2017-08-30" version="1">MQLCPLPSEGILQIKKNRYYKTARSKSHFHFQDHLPKHLTVKNTYSEEHFKAIQNVANEANAKTCTDHNEPVKNSIHRTASEECGFETGTSKLHSYACVIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1KED8</accession>
    <name>A0A1Y1KED8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Minor histocompatibility antigen H13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PPYR_00450</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase A22B family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01087040">
        <property type="protein sequence ID" value="JAV58898.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1KED8"/>
    <dbReference type="FunCoup" id="A0A1Y1KED8">
        <property type="interactions" value="1901"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1KED8"/>
    <dbReference type="OrthoDB" id="29661at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098554">
        <property type="term" value="C:cytoplasmic side of endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:lumenal side of endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042500">
        <property type="term" value="F:aspartic endopeptidase activity, intramembrane cleaving"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033619">
        <property type="term" value="P:membrane protein proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007369">
        <property type="entry name" value="Peptidase_A22B_SPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006639">
        <property type="entry name" value="Preselin/SPP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12174:SF23">
        <property type="entry name" value="MINOR HISTOCOMPATIBILITY ANTIGEN H13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12174">
        <property type="entry name" value="SIGNAL PEPTIDE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04258">
        <property type="entry name" value="Peptidase_A22B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00730">
        <property type="entry name" value="PSN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="209"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="253"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="289"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="318"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="347"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="355"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006859"/>
        </source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="JAV58898.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAB0803480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="372" mass="41045" checksum="86D9D0B71F0BB113" modified="2017-08-30" version="1">MAYGSVVNFIVAQAAENVSETAANATTKPPSTPEGIAVAYGSLVIMALLPIFFGSYRSACVHKEQKHETMTTRDAAMFPIMASIALFGLYIIFKLFSKEHINLLLTGYFFFLGVLALTQVLSPIVSKLVPAAVPNIKYHILFTQGEDDNKQDIINYKFTSHDIVALICCLGVGAWYLIQKHWVANNLFGLAFAVNAVELLRLNNVVTGCILLSGLFIYDIFWVFGTDVMVTVAKSFEAPIKLVFPQDLLTHGFAANNFAMLGLGDIVVPGIFIALLLRFDHSLNRQSKLYFHATFVAYFLGLMTTILVMHVFKHAQPALLYLVPACLGTPLAVALVKGDLTALFKYEDSSNEEEESKKDEKQTKPAESKKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1KGZ8</accession>
    <name>A0A1Y1KGZ8_PHOPY</name>
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        <recommendedName>
            <fullName evidence="14">Receptor protein-tyrosine kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PPYR_05505</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="JAV58686.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
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    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
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        <property type="entry name" value="RTK"/>
    </dbReference>
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        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF604">
        <property type="entry name" value="RECEPTOR PROTEIN-TYROSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fn3_PTPRU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Protein kinase-like (PK-like)"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
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        </location>
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        </location>
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        </location>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023180"/>
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    </evidence>
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        </source>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="JAV58686.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAB0801151.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
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    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="726" mass="82089" checksum="8C68BAC1D19590C0" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1KH97</accession>
    <name>A0A1Y1KH97_PHOPY</name>
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        <recommendedName>
            <fullName evidence="7">Protein bicaudal D</fullName>
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    </protein>
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    </gene>
    <organism evidence="4">
        <name type="scientific">Photinus pyralis</name>
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            <taxon>Insecta</taxon>
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            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
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            <taxon>Elateroidea</taxon>
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        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
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            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
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                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BicD family.</text>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR31233:SF6">
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    </dbReference>
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        <property type="entry name" value="BicD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="7"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="99"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="162"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="315"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="402"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="603"/>
            <end position="736"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="JAV59771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0803717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="761" mass="87523" checksum="EF0B60215EC61584" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1KP79</accession>
    <name>A0A1Y1KP79_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CLIP domain-containing serine protease</fullName>
            <ecNumber evidence="8">3.4.21.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PPYR_04482</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="9">The clip domain consists of 35-55 residues which are 'knitted' together usually by 3 conserved disulfide bonds forming a clip-like compact structure.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 9">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
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    <dbReference type="EMBL" id="GEZM01081961">
        <property type="protein sequence ID" value="JAV61465.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
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    <dbReference type="EMBL" id="VVIM01000002">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="FunCoup" id="A0A1Y1KP79">
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    <dbReference type="InParanoid" id="A0A1Y1KP79"/>
    <dbReference type="OrthoDB" id="8114044at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000028">
        <property type="entry name" value="Serine protease easter"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Serine protease easter"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051487">
        <property type="entry name" value="Ser/Thr_Proteases_Immune/Dev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24256">
        <property type="entry name" value="TRYPTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12032">
        <property type="entry name" value="CLIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00680">
        <property type="entry name" value="CLIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51888">
        <property type="entry name" value="CLIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 8" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 8" id="KW-0720">Serine protease</keyword>
    <keyword evidence="2 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033828459" description="CLIP domain-containing serine protease" evidence="9">
        <location>
            <begin position="22"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="Clip" evidence="12">
        <location>
            <begin position="23"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="11">
        <location>
            <begin position="116"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="JAV61465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAB0802296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="376" mass="41417" checksum="5BE6E80922DD90DF" modified="2017-08-30" version="1">MLNSFSVPVAVFLCLFFNAYGQRCTTPNDEVAQCISIYDCGVLYNSITSKDPSVIRFLRQSQCDYQQVPYVCCGTSATYRNPSRRPTDRPPASTGGRPASLLPNRATCGFQEGAKVLGGVQTTHSEFPWMALMEYRKNVGGGRTFSCGGALISNRYVLTAAHCVTGKIREQVGPLISVRLGEWNTETSQDCVTVEGFELCNDEPLNVAVESVVAHNDYDDSSINRYHDIALVRLARNVQFTDFIQPICLPTSSERASIGNQLWVSGWGRTEYANSSPVKLKVRLPIVSNSQCANTFRRAGVQLSNTQLCAGGERNKDSCNGDSGGPLMQVMNRDSNPQWYIEGIVSFGTRCGTENWPGIYTRVVDYLGWISNNMSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1KPJ1</accession>
    <name>A0A1Y1KPJ1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transmembrane protein 184C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_12632</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
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        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GEZM01081603">
        <property type="protein sequence ID" value="JAV61585.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1KPJ1"/>
    <dbReference type="FunCoup" id="A0A1Y1KPJ1">
        <property type="interactions" value="1034"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1KPJ1"/>
    <dbReference type="OrthoDB" id="5348404at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005178">
        <property type="entry name" value="Ostalpha/TMEM184C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23423">
        <property type="entry name" value="ORGANIC SOLUTE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03619">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01417">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="70"/>
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                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
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                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
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                <person name="Shigenobu S."/>
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                <person name="Sander Lower S.E."/>
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                <person name="Bessho-Uehara M."/>
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                <person name="Debat H.J."/>
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                <person name="Debat H.J."/>
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                <person name="Day J.C."/>
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                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
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                <person name="Shigenobu S."/>
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                <person name="Sander Lower S.E."/>
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            <strain evidence="4">1611_PpyrPB1</strain>
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    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="JAV67775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0803813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="188" mass="21155" checksum="FC9754CE8EE2F9AA" modified="2017-08-30" version="1">MKQNAFWGKIAALMAKEGFAVIGTQYRTNLATLKRQYKKIKDHNKRSGSNRTDWPYLEIMDDLFGSKPWVEPLSTASSSSASDPKSEGPIAIEPQISTDPELQCNDPLPPVVRSTSMSGEPVTSRNAVKGTRINQKKKLQRTGSANRVADVLEKLRQDRQTQHEQRMSQKQEALDLLRSLVDKMSKQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LAV2</accession>
    <name>A0A1Y1LAV2_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein mL54</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_00947</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the mitochondrion-specific ribosomal protein mL54 family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01061014">
        <property type="protein sequence ID" value="JAV70789.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1LAV2"/>
    <dbReference type="FunCoup" id="A0A1Y1LAV2">
        <property type="interactions" value="168"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1LAV2"/>
    <dbReference type="OrthoDB" id="10252718at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013870">
        <property type="entry name" value="Ribosomal_mL54"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28595">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L54, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28595:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08561">
        <property type="entry name" value="Ribosomal_L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="JAV70789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0803977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="131" mass="15048" checksum="7D856931FE9BB43D" modified="2017-08-30" version="1">MHIFKELIKGNRFNLINSFSRMTYAKATVLGGALKKKKGGKGGPMTEKRVLPVETDPERLVNYACGTNIFKTGEDVKLLPDSEYPTWLWDVRTGPPPPLEELDPNSKEYWRRVRKMAIKRNTQLARINMLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LCG9</accession>
    <name>A0A1Y1LCG9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-hydroxyisobutyrate dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PPYR_00240</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>3-hydroxy-2-methylpropanoate + NAD(+) = 2-methyl-3-oxopropanoate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17681"/>
            <dbReference type="ChEBI" id="CHEBI:11805"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57700"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-valine degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HIBADH-related family. 3-hydroxyisobutyrate dehydrogenase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.31" evidence="3"/>
    <dbReference type="EMBL" id="GEZM01061281">
        <property type="protein sequence ID" value="JAV70571.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1LCG9"/>
    <dbReference type="FunCoup" id="A0A1Y1LCG9">
        <property type="interactions" value="1053"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1LCG9"/>
    <dbReference type="OrthoDB" id="435038at2759"/>
    <dbReference type="UniPathway" id="UPA00362"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008442">
        <property type="term" value="F:3-hydroxyisobutyrate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000006">
        <property type="entry name" value="3-hydroxyisobutyrate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011548">
        <property type="entry name" value="HIBADH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="HIBADH-like_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01692">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22981:SF7">
        <property type="entry name" value="3-HYDROXYISOBUTYRATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22981">
        <property type="entry name" value="3-HYDROXYISOBUTYRATE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0101">Branched-chain amino acid catabolism</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase NADP-binding" evidence="9">
        <location>
            <begin position="24"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyisobutyrate dehydrogenase-like NAD-binding" evidence="10">
        <location>
            <begin position="184"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000103-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="JAV70571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAB0803270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="320" mass="33755" checksum="66406737D81E28BE" modified="2017-08-30" version="1">MLQKRLIVLFRSTHKHFQQRNKSDVGFIGIGNMGQRMATNLIKKGRTVKVYDASKTAAQTVAGAKVCATPQEAATDVDFVITMLPDGDIVKKVLTAEDGVLKGIKKSALYVDSSTINPITAQELHKITAGEGIQFLDAPVSGGVTGASAATLTFMLGGSQEIAKKVEPYLLQMGGRIMHCGGPGAGQIAKLCNNLILGICMIGVAEGMNLGAKMGLDVKTLSQVVNTSTGRCWSSDTYNPVPGIMENVPSADNYNGGFQVQLIAKDMALASNVAVSCGAPIPLGSAAHQMYRTLAAYGKGNKDFGIVYQFLQGQLDSLPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LL89</accession>
    <name>A0A1Y1LL89_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">WW domain-containing oxidoreductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PPYR_03200</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Lysosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GEZM01052549">
        <property type="protein sequence ID" value="JAV74444.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1LL89"/>
    <dbReference type="FunCoup" id="A0A1Y1LL89">
        <property type="interactions" value="288"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1LL89"/>
    <dbReference type="OrthoDB" id="9989144at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000353">
        <property type="entry name" value="WW domain-containing oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0458">Lysosome</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="domain" description="WW" evidence="9">
        <location>
            <begin position="10"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="9">
        <location>
            <begin position="51"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="JAV74444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0791400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="401" mass="44699" checksum="758D06DD383F45CF" modified="2017-08-30" version="1">MNLPESDSEEELPPGWEERVTADGSVFYANHLTKNTQWTHPRTGRKKVVSGELPYGWERCIDKATQKIIYIDHENRRTTYTDPRLAFAVEEKDHPNDFRQRFDASSTALQVLHGRDLTGKVALITGANAGIGYETARSLAKHSCTVIFACRNVESARAAIDRIAEEKSTVADLCEAVHLDLTSLKSVVDCANFIKTKHKQLDMLILNAGVFGLPYTKTIDGYETTFQVNHLAHFHLANLLLPLLVTGSRVVIVSSESHRFANLTVDNLTTALSPDVPSKYWDMTAYNNSKLCNVLFGRQLAKNLQSNGVGVFTLHPGNMVSSSLTRNWWLYRLLFGLVRPFTKSLQQAASTTVYCATAVELNGVTGVYFNNCFRCRESESAQSDELATALWNLSAEMISNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LM47</accession>
    <name>A0A1Y1LM47_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_02881</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01055645">
        <property type="protein sequence ID" value="JAV72995.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1LM47"/>
    <dbReference type="InParanoid" id="A0A1Y1LM47"/>
    <dbReference type="OrthoDB" id="366390at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="43"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="76"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="122"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="180"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="217"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="253"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="289"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="JAV72995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0791081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="465" mass="52401" checksum="3E6E6A37ED182BAE" modified="2017-08-30" version="1">MPAECIANPLQRELADCIIRMVPLDEIRILLACGAKVSEPVTQGLTPLHYAVWQRYYEAAQLLLTRGCNVNAIDECGYSPLHLSAEHGYTDVVKLLILSGAKVDYRENTEEPFPRTTLCDEPLRMAIRNKHMDIARLLLENGADPNKRYFFGSEINLVNDLEYLELLLTFGANADSRDRAGLTPLMKAARQPQGMEAVLLLLHHGADVNAVADERHDYRTVLHYAVLSGNIDIVNLLIKQGAKLNYDEEFDLGKPSPLDLAILKGDPEIIRLLVQSGANVNCSSSIIGSPLHVACADNISNRYEIIQMLLKAGADPNVKVFNDSENRNSQLRSVLAEYLASNEDPNVTIVNMLLRYGARVIMKTQFRDPDGILNSLQNVVNSKSEQLFYLLVEGCESFDSCMIRRNNVITPEQKDVLLELAKCPLSLRRQVRLYLRRLYGRRLIDMACNLELPQCLVKYLLFEYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LN46</accession>
    <name>A0A1Y1LN46_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Dehydrogenase/reductase SDR family member 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_03290</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01051277">
        <property type="protein sequence ID" value="JAV75062.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1LN46"/>
    <dbReference type="FunCoup" id="A0A1Y1LN46">
        <property type="interactions" value="641"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1LN46"/>
    <dbReference type="OrthoDB" id="1669814at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004090">
        <property type="term" value="F:carbonyl reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005559">
        <property type="entry name" value="PRK07231.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43943">
        <property type="entry name" value="DEHYDROGENASE/REDUCTASE (SDR FAMILY) MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43943:SF2">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="JAV75062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0791490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="312" mass="33136" checksum="298DA1CB4751A921" modified="2017-08-30" version="1">MNGMLIHPWELPTYAPGLWSLRIKSKFEFQSAHSSCCIFNPQFVMIGRGIRLLSNMAMANPRLDGKVAVVTASTEGIGFAIAKRLAQEGAKVVVSSRNKAKVDAAISQLKKEGLGEKVIGAVCHVGKAEDRKRIFDEAAKLGGLDILVSNAGVSPAMGPILDCSEQVWDKIFELNVKAGFLLAKDAMPHFKKRGGGKIIFISSIGGYQPIPFIGAYCVSKTALLGLTKVIASDVAGDNVTVNCIAPGIIETKFSQPLISEEANQEHIVSLTALKRLGKPNDVAGVAAFLASSDSDYITGETILVTGGIPARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1MAK5</accession>
    <name>A0A1Y1MAK5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Bcl-2 Bcl-2 homology region 1-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PPYR_08348</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Bcl-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01038619">
        <property type="protein sequence ID" value="JAV81590.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01038618">
        <property type="protein sequence ID" value="JAV81591.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01038617">
        <property type="protein sequence ID" value="JAV81592.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1MAK5"/>
    <dbReference type="FunCoup" id="A0A1Y1MAK5">
        <property type="interactions" value="159"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1MAK5"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051400">
        <property type="term" value="F:BH domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097192">
        <property type="term" value="P:extrinsic apoptotic signaling pathway in absence of ligand"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008630">
        <property type="term" value="P:intrinsic apoptotic signaling pathway in response to DNA damage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001836">
        <property type="term" value="P:release of cytochrome c from mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06845">
        <property type="entry name" value="Bcl-2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.437.10:FF:000009">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.437.10">
        <property type="entry name" value="Blc2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036834">
        <property type="entry name" value="Bcl-2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046371">
        <property type="entry name" value="Bcl-2_BH1-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026298">
        <property type="entry name" value="Bcl-2_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002475">
        <property type="entry name" value="Bcl2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11256">
        <property type="entry name" value="BCL-2 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11256:SF48">
        <property type="entry name" value="BCL-2-RELATED OVARIAN KILLER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00452">
        <property type="entry name" value="Bcl-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01862">
        <property type="entry name" value="BCL2FAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00337">
        <property type="entry name" value="BCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56854">
        <property type="entry name" value="Bcl-2 inhibitors of programmed cell death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50062">
        <property type="entry name" value="BCL2_FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="Bcl-2 Bcl-2 homology region 1-3" evidence="8">
        <location>
            <begin position="145"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="JAV81590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0797354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="294" mass="32237" checksum="7A692A285B0F9FCE" modified="2017-08-30" version="1">MDDATPTNVNGDGNISFETPPMARLQMGQYPFSKRKFSFPASLHANLLGLPGKEKGGKDAKNSMRRFSNVGDVVSRKLSYTIGWKSLDNSPPQEVILQGRMLCGQYIKSRLKRSGIFSKKVCFYRLRSVIGTPSGTVVKEVTPFLMAAGVELERMYPKLYTSISRKASGSPGGVLVSDKTAAGLFAAIAQELLKYDITWGKVVSLFAVAGGLAVDCVCQGHPEYLHSLLESMTEVLEDNLAEWVANHGGWTALCAQCSYPETDLPLIDYASKAILVLILLVILYFIIRFVQKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1MB16</accession>
    <name>A0A1Y1MB16_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein mL51</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">39S ribosomal protein L51, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PPYR_15142</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL51 family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01036337">
        <property type="protein sequence ID" value="JAV82774.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01036336">
        <property type="protein sequence ID" value="JAV82776.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01036335">
        <property type="protein sequence ID" value="JAV82780.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01036334">
        <property type="protein sequence ID" value="JAV82782.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01036333">
        <property type="protein sequence ID" value="JAV82785.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01036332">
        <property type="protein sequence ID" value="JAV82788.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01036331">
        <property type="protein sequence ID" value="JAV82794.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01036330">
        <property type="protein sequence ID" value="JAV82795.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01036329">
        <property type="protein sequence ID" value="JAV82797.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01036328">
        <property type="protein sequence ID" value="JAV82801.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01036327">
        <property type="protein sequence ID" value="JAV82803.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01036326">
        <property type="protein sequence ID" value="JAV82809.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01001249">
        <property type="protein sequence ID" value="KAB0790453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1MB16"/>
    <dbReference type="FunCoup" id="A0A1Y1MB16">
        <property type="interactions" value="190"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1MB16"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019373">
        <property type="entry name" value="Ribosomal_mL51"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13409:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13409">
        <property type="entry name" value="MITOCHONDRIAL 39S RIBOSOMAL PROTEIN L51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10244">
        <property type="entry name" value="MRP-L51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="JAV82801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0790453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="164" mass="19684" checksum="D403A48F1F5084FA" modified="2017-08-30" version="1">MIPFVNTVANFCQKCIWNPQRISVRYRYHSEKIAKGPLIRRYGYDDPLFKGGLLPRLKNAPKLPMPTYRPKDAWNEKRALFGQNDYIDILGNEKLHPTRILYNVPYWLRGVSGNEYQVLLRKRKMLGRTPYHTVRPTKWYELNKRINYLYRYLNRKTKTGFSVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1MLF7</accession>
    <name>A0A1Y1MLF7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Sulfide:quinone oxidoreductase, mitochondrial</fullName>
            <ecNumber evidence="14">1.8.5.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Sulfide quinone oxidoreductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PPYR_00884</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="19 20" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">1611_PpyrPB1</strain>
            <tissue evidence="19">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">1611_PpyrPB1</strain>
            <tissue evidence="19">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the oxidation of hydrogen sulfide with the help of a quinone, such as ubiquinone-10, giving rise to thiosulfate and ultimately to sulfane (molecular sulfur) atoms. Requires an additional electron acceptor; can use sulfite, sulfide or cyanide (in vitro). It is believed the in vivo electron acceptor is glutathione.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol</text>
            <dbReference type="Rhea" id="RHEA:55156"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58905"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.8.5.8"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:55157"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ubiquinone-10 + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + ubiquinol-10</text>
            <dbReference type="Rhea" id="RHEA:62608"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:46245"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58905"/>
            <dbReference type="ChEBI" id="CHEBI:64183"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:62609"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ubiquinone-10 + hydrogen sulfide + sulfite + 2 H(+) = ubiquinol-10 + thiosulfate</text>
            <dbReference type="Rhea" id="RHEA:38359"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:33542"/>
            <dbReference type="ChEBI" id="CHEBI:46245"/>
            <dbReference type="ChEBI" id="CHEBI:64183"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:38360"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the SQRD family.</text>
    </comment>
    <dbReference type="EC" id="1.8.5.8" evidence="14"/>
    <dbReference type="EMBL" id="GEZM01029788">
        <property type="protein sequence ID" value="JAV85928.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1MLF7"/>
    <dbReference type="FunCoup" id="A0A1Y1MLF7">
        <property type="interactions" value="472"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1MLF7"/>
    <dbReference type="OrthoDB" id="5376590at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106436">
        <property type="term" value="F:glutathione-dependent sulfide quinone oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070224">
        <property type="term" value="F:sulfide:quinone oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070221">
        <property type="term" value="P:sulfide oxidation, using sulfide:quinone oxidoreductase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000034">
        <property type="entry name" value="sulfide:quinone oxidoreductase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015904">
        <property type="entry name" value="Sulphide_quinone_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10632">
        <property type="entry name" value="SULFIDE:QUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10632:SF2">
        <property type="entry name" value="SULFIDE:QUINONE OXIDOREDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0874">Quinone</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="17">
        <location>
            <begin position="31"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00052810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00052986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00059167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00060891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00066447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00070160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00082958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="JAV85928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAB0803914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="440" mass="49422" checksum="C6CF9D1C47F7FE8A" modified="2017-08-30" version="1">MLILRRTTNLKTAILRCLSTSSAPVENRKCRLLVVGGGSGGCTMAAKFGKHFNKGEIFIVEPSDTHYYQPLFTLVGGGIKKLADCGKPMKSVLPDTAKWIKDSVTEFNPQRNSVTVSRGDEITYDFMIVATGLQLNYDKIPGLVEALNVPNTGVCSNYSYKYVNRTYEILKQFKSGNAIFTYPNSPVKCPGAPQKICYIAEDFFTRNGIRDKVNITYNTSLPVLFGVKKYADALWKVVEKRNINVNLRCNLVEVKHKEKVAVFQNLDVPEQLTEMEYSMLHVTPPMSTPDSLKKCTDLVNDLGFVNVNKDTLQHFKYPNVFAIGDCSATPNSKTAASVAAQSNIVYENMKAVMENQPLKGKYNGYASCPLVTGYGKCILAEFDYDLNPLETFPISQDKEMWLMYTMKKDFMPPLYWHLMLNGKWNGPGAVRDLLHFNFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1MQT5</accession>
    <name>A0A1Y1MQT5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL15</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L27a</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PPYR_07720</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uL15 family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01025503">
        <property type="protein sequence ID" value="JAV87428.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1MQT5"/>
    <dbReference type="FunCoup" id="A0A1Y1MQT5">
        <property type="interactions" value="1230"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1MQT5"/>
    <dbReference type="OrthoDB" id="61900at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.100.10.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L27a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01341">
        <property type="entry name" value="Ribosomal_uL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030878">
        <property type="entry name" value="Ribosomal_uL15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_uL15/eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="Ribosomal_uL15/eL18_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001196">
        <property type="entry name" value="Ribosomal_uL15_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11721">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11721:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00828">
        <property type="entry name" value="Ribosomal_L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="Ribosomal proteins L15p and L18e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00475">
        <property type="entry name" value="RIBOSOMAL_L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL15/eL18" evidence="8">
        <location>
            <begin position="72"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="JAV87428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0799840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="148" mass="16506" checksum="2AC84F174CEF9970" modified="2017-08-30" version="1">MATGKKKTRKLRGHVSHGHGRIGKHRKHPGGRGNAGGLHHHRINFDKYHPGYFGKLGMRNYHVKKNSKWCPIINLNTLWSLVSEETRLKYKNDKEGKAPVIDVVQHGFHKVLGKGTLPNQPVIVRAKLFSKLAESKIKAAGGACVLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1MSL6</accession>
    <name>A0A1Y1MSL6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_10723</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01025369">
        <property type="protein sequence ID" value="JAV87490.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1MSL6"/>
    <dbReference type="FunCoup" id="A0A1Y1MSL6">
        <property type="interactions" value="2017"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1MSL6"/>
    <dbReference type="OrthoDB" id="10254455at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140570">
        <property type="term" value="P:extraction of mislocalized protein from mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19520">
        <property type="entry name" value="RecA-like_ATAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000538">
        <property type="entry name" value="ATPase family AAA domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051701">
        <property type="entry name" value="Mito_OM_Translocase_MSP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45644">
        <property type="entry name" value="AAA ATPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G12920)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45644:SF3">
        <property type="entry name" value="FI08533P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="7">
        <location>
            <begin position="126"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="JAV87490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0796662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="377" mass="42179" checksum="EFE84542F32DC1F5" modified="2017-08-30" version="1">MMSDTFSRTEIIGLVVRLTLVSAVTFLSIKWLMNQVDPTNKSKKKAKKRAQEQLRRLAGSGNTPLSVDKLSDYEMMIAAHLVHPEDILVTWEDIAGLQGLVQELRETVILPIQRKDLFTDSQLTQPPKGVLLHGPPGCGKTLIAKATAKEAGTRFINLDVSILTDKWYGESQKLAAAVFTLAVKLQPCIVFIDEIDSFLRMRNSTDHEATAMMKAQFMSFWDGLSTDSSCTVIIMGATNRPQDLDRAILRRMPATFHVPMPNAPQRLQILQLILENEPVSSEVNLTTLSKSTDGFSGSDLRELCRNASVYRVRDYMRNVPANEEACISNRNAMTDSEDEFHDALRPITMDDLVKSLNKMKESKMHCGSLPVPRLDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1MUI8</accession>
    <name>A0A1Y1MUI8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Vesicle-associated membrane protein 7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Synaptobrevin-like protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PPYR_07482</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="20 21" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">1611_PpyrPB1</strain>
            <tissue evidence="20">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">1611_PpyrPB1</strain>
            <tissue evidence="20">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasmic vesicle</location>
            <location evidence="12">Phagosome membrane</location>
            <topology evidence="12">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Cytoplasmic vesicle</location>
            <location evidence="9">Secretory vesicle membrane</location>
            <topology evidence="9">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Golgi apparatus</location>
            <location evidence="8">trans-Golgi network membrane</location>
            <topology evidence="8">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Late endosome membrane</location>
            <topology evidence="10">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Lysosome membrane</location>
            <topology evidence="11">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the synaptobrevin family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01021913">
        <property type="protein sequence ID" value="JAV88827.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01021912">
        <property type="protein sequence ID" value="JAV88828.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1MUI8"/>
    <dbReference type="FunCoup" id="A0A1Y1MUI8">
        <property type="interactions" value="1033"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1MUI8"/>
    <dbReference type="OrthoDB" id="248747at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030670">
        <property type="term" value="C:phagocytic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030658">
        <property type="term" value="C:transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14824">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15871">
        <property type="entry name" value="R-SNARE_VAMP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.50:FF:000015">
        <property type="entry name" value="Synaptobrevin 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000004">
        <property type="entry name" value="Vesicle-associated membrane protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.50">
        <property type="entry name" value="Longin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010908">
        <property type="entry name" value="Longin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051097">
        <property type="entry name" value="Synaptobrevin-like_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21136">
        <property type="entry name" value="SNARE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21136:SF179">
        <property type="entry name" value="VESICLE ASSOCIATED MEMBRANE PROTEIN 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13774">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01270">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50859">
        <property type="entry name" value="LONGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="189"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Longin" evidence="17">
        <location>
            <begin position="7"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="18">
        <location>
            <begin position="125"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00039269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00042194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="JAV88828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAB0799602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="221" mass="25150" checksum="A08729693F980AE4" modified="2017-08-30" version="1">MPILYSVISRGTTVLAKYASCAGNFPEVTEQVISKIPLQDNKLTYTHGNYLFHYICESRIIYMCITDDDFERSRAFLFLNEIKRRFKTNYGANVDTAMGYAMNSEFASILANEMKHYSESSDVDTISKVHGELDELKNIMVKNIDNIAMRGERLELLINKAENLSNNSLAYRKTSRNLARSLFWKNVKLYVILAVIVAVIIYIIVCLSCGGLLWQGCISKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1N1P5</accession>
    <name>A0A1Y1N1P5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DET1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_09632</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01015300">
        <property type="protein sequence ID" value="JAV91769.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1N1P5"/>
    <dbReference type="FunCoup" id="A0A1Y1N1P5">
        <property type="interactions" value="777"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1N1P5"/>
    <dbReference type="OrthoDB" id="18339at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031461">
        <property type="term" value="C:cullin-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990756">
        <property type="term" value="F:ubiquitin-like ligase-substrate adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032436">
        <property type="term" value="P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019138">
        <property type="entry name" value="De-etiolated_protein_1_Det1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13374:SF3">
        <property type="entry name" value="DET1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    <sequence length="563" mass="65605" checksum="1EF1527822E87CB2" modified="2017-08-30" version="1"> </sequence>
</entry>
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    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
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                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">1611_PpyrPB1</strain>
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        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
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                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="4">1611_PpyrPB1</strain>
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        </source>
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    </evidence>
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    </evidence>
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        <source>
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</entry>
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    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
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                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
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            <dbReference type="PubMed" id="30324905"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
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        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
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        <property type="molecule type" value="Transcribed_RNA"/>
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    </dbReference>
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        <source>
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        <source>
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    </evidence>
    <sequence length="535" mass="61119" checksum="0C0FB35315B05AC5" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
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            <taxon>Coleoptera</taxon>
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        </lineage>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
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        <property type="protein sequence ID" value="JAV93694.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792394.1"/>
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        <property type="term" value="F:odorant binding"/>
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        <location>
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        <location>
            <begin position="20"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="JAV93694.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0792394.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
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    <sequence length="143" mass="16631" checksum="7F9F3A522810CD81" modified="2017-08-30" version="1">MYAAVRFLTILCAVHQVFSNEERNYWGDPISVECIEEVHFDKTILPTVMDKDFYIVSTDPSVFELFRCMFEKLKMVQDGKFVKDEIVRYVEKGPVRFLKPNADNPNKIALEAYEGCKSLEGDGIGQQAVNMRNCIIREIYKYK</sequence>
</entry>
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    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
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                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
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                <person name="Lewis S.M."/>
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            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX ASSEMBLY FACTOR 3"/>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00049984"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0798430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="196" mass="22313" checksum="5AA070BF1E8906D2" modified="2017-08-30" version="1">MFHNCVQSILRTTRYNYNVKHFRRFISTNQLNCGSSYQGDGKTTAHILNSDADSGLLINGISEVGFRLNNSVTVLGPMVIFPRSVLSWCIRDIRDINEESLSLFTILEPSIEIIVLGVGDSLENPKFYQSLLPFMRKHLINIEVLPTEQACTTFNFLNSEGRYVAAGLIPPQVLQTTDDDLLRTKLRYQNLYETNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1NF18</accession>
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    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
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            <dbReference type="DOI" id="10.1038/srep38556"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
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            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">1611_PpyrPB1</strain>
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    <reference evidence="15" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">1611_PpyrPB1</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
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    <comment type="subcellular location">
        <subcellularLocation>
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            <location evidence="1">Nucleoplasm</location>
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        <text evidence="2">Belongs to the THAP1 family.</text>
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        <property type="molecule type" value="Transcribed_RNA"/>
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        <property type="molecule type" value="Transcribed_RNA"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="THAP DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR46600:SF1">
        <property type="entry name" value="THAP DOMAIN-CONTAINING PROTEIN 1"/>
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    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 12" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="JAV94247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAB0805002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="298" mass="34575" checksum="C1FBD861C6DB1544" modified="2017-08-30" version="1">MGRKCCVPSCKSGYLSCTEKYSVFSIPGDKVRKFNKLIPRKDPNITAKYYVCERHFEKKFIIREIKTECYSYALDKPRLSDDAVPTIFPDCPSYLSKLKAKEQRRVIWDTPVNKRKRYNAGNNPGSSSTSGYDFASDSSTNLVDFASKINFNKDISLPSNWATHYLQSNLASCIIYFSKVVVYESRPITQVSLMLEKATLKCFVFNKDTNTYNLDHLKTVQDFKTYITDTITAFDNFFYCYGYPNSKVPSHFCNKNYLKDSYVNVWRHSKCSYFTETVSTKNTRVNRCTQCRKINRCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1NH56</accession>
    <name>A0A1Y1NH56_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ARMC9 CTLH-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_12447</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Early endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Late endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat WDR91 family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01005716">
        <property type="protein sequence ID" value="JAV95975.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0795608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1NH56"/>
    <dbReference type="FunCoup" id="A0A1Y1NH56">
        <property type="interactions" value="29"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1NH56"/>
    <dbReference type="OrthoDB" id="193023at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141039">
        <property type="term" value="F:phosphatidylinositol 3-kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045022">
        <property type="term" value="P:early endosome to late endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051898">
        <property type="term" value="P:negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056327">
        <property type="entry name" value="ARMC9_CTLH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039724">
        <property type="entry name" value="WDR91"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13083">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 91"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13083:SF3">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 91"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23138">
        <property type="entry name" value="CTLH_Armc9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ARMC9 CTLH-like" evidence="7">
        <location>
            <begin position="46"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="250"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="177"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="272"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF23138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="JAV95975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0795608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="288" mass="33646" checksum="FA17A56324556676" modified="2017-08-30" version="1">MAHVQYLDELIREYLVHRGFGTTVKALDIDLKSDKEKSFRVDKIVEQLVQFVNNYDLISLRELWGHLETHMFTKLESHFVPATKKLENAILKLYLINVIVNNKSEKMAEFFMKMTPEIHNQSEWKDWFMLPYIKNPEENPTFSLHFTRQWQDTLLVSLHNFLATIFQYMPTPALMHFEEDANKIRKLEEKNESLKNRLAQLIDKGPETTVTPCHVEPPLHLLDDFYIIAQESTTTDNQAKSLKNLIRNMGTGSSPILGRKETSSNTNKKKLSTITSKTKSSQNYFHEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-06-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N3ZY81</accession>
    <name>A0A5N3ZY81_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_15689</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01002059">
        <property type="protein sequence ID" value="KAB0790020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N3ZY81"/>
    <dbReference type="InParanoid" id="A0A5N3ZY81"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0790020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="99" mass="11939" checksum="7F54EE21FBB73B4D" modified="2020-02-26" version="1">MYDRVLSDTTNNYAEAAHRRMQTELGMDLWKFIYRLKKIQHGRDLAIAGRQPDKKLNKYLRGDQNIKNIVQDFRNRNIVDYLKCLTHNYQMDPDFLVLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N3ZYA4</accession>
    <name>A0A5N3ZYA4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phenoloxidase-activating factor 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Prophenoloxidase-activating factor II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PPYR_15645</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01002028">
        <property type="protein sequence ID" value="KAB0790040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N3ZYA4"/>
    <dbReference type="InParanoid" id="A0A5N3ZYA4"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000038">
        <property type="entry name" value="Serine protease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041515">
        <property type="entry name" value="PPAF-2-like_Clip"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24258:SF129">
        <property type="entry name" value="LP15124P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24258">
        <property type="entry name" value="SERINE PROTEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18322">
        <property type="entry name" value="CLIP_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024341291" description="Phenoloxidase-activating factor 2" evidence="6">
        <location>
            <begin position="19"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="7">
        <location>
            <begin position="129"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="7">
        <location>
            <begin position="531"/>
            <end position="781"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00068096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00076468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0790040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="792" mass="86845" checksum="412E16A1A4C586FA" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N3ZZ89</accession>
    <name>A0A5N3ZZ89_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Regulatory protein zeste</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PPYR_15249</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in transvection phenomena (= synapsis-dependent gene expression), where the synaptic pairing of chromosomes carrying genes with which zeste interacts influences the expression of these genes. Zeste binds to DNA and stimulates transcription from a nearby promoter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Self-associates forming complexes of several hundred monomers.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01001386">
        <property type="protein sequence ID" value="KAB0790385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N3ZZ89"/>
    <dbReference type="InParanoid" id="A0A5N3ZZ89"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028002">
        <property type="entry name" value="Myb_DNA-bind_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23098">
        <property type="entry name" value="AGAP001331-PA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23098:SF23">
        <property type="entry name" value="MYB-RELATED TRANSCRIPTION FACTOR, PARTNER OF PROFILIN-LIKE ISOFORM X2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13873">
        <property type="entry name" value="Myb_DNA-bind_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Myb/SANT-like DNA-binding" evidence="7">
        <location>
            <begin position="7"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="221"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0790385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="269" mass="31202" checksum="1373C82041E058E4" modified="2020-02-26" version="1">MATKRQRTINFSEKEVRLLTDICLKYSSILENKKTDAVTWKEKNTTWEQITAEFNSQNESSNYRDTKNLRLKYDCLKREIKAKKAKNKLEIYKTGGGKPEGTPYTDYEEKILDVITLSLEGLPCRHDSDNALIIDNGIDMVETLPFTAISNLENIPFDIPLSEIDIAAPVARELETSIIPSTSKKWTSGKKKRLQPQERQYFNKKYEQITNNRTTLITLQTENAEWEKQLLLSKIKFAEEEYMLKMKLLKLNIRKAEINLLQAEKGTLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N3ZZ95</accession>
    <name>A0A5N3ZZ95_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PiggyBac transposable element-derived protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_15242</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01001381">
        <property type="protein sequence ID" value="KAB0790394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N3ZZ95"/>
    <dbReference type="InParanoid" id="A0A5N3ZZ95"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599:SF6">
        <property type="entry name" value="DUAL SPECIFICITY PHOSPHATASE 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="1">
        <location>
            <begin position="3"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0790394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="133" mass="15046" checksum="BAC4EEA83DE570BA" modified="2020-02-26" version="1" fragment="single">SLTSNLKVYVGLQPEGPYALQTSPFAVVQRLVEPIKRSKRNVTCDNWFSGVPSVNTLLTDFSLTFLGTIRKNKRELPLEISNPTKRAIGSNMFAYNKTVTLVSYIPKRNKNVTLISSLHHDDKIDQAQENPKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N3ZZC9</accession>
    <name>A0A5N3ZZC9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FAS1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_15205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01001312">
        <property type="protein sequence ID" value="KAB0790427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N3ZZC9"/>
    <dbReference type="FunCoup" id="A0A5N3ZZC9">
        <property type="interactions" value="45"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N3ZZC9"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050839">
        <property type="term" value="F:cell adhesion molecule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.180.10:FF:000032">
        <property type="entry name" value="Fasciclin domain-containing protein, putative"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050904">
        <property type="entry name" value="Adhesion/Biosynth-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900:SF77">
        <property type="entry name" value="FI19380P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900">
        <property type="entry name" value="PERIOSTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00554">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAS1" evidence="1">
        <location>
            <begin position="107"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="1">
        <location>
            <begin position="256"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="1">
        <location>
            <begin position="392"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="1">
        <location>
            <begin position="537"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0790427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="690" mass="77291" checksum="3892A62B17F3363F" modified="2020-02-26" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-06-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N3ZZS7</accession>
    <name>A0A5N3ZZS7_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_15045</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01001125">
        <property type="protein sequence ID" value="KAB0790549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N3ZZS7"/>
    <dbReference type="InParanoid" id="A0A5N3ZZS7"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0790549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="60" mass="6807" checksum="2B844366FB878456" modified="2020-02-26" version="1" fragment="single">EVDGNTILGNWRTDNQEISSSLLPVRNIPRRSKPVPTNIRLEFTEYFCSNGAVPWQSKCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A1B8</accession>
    <name>A0A5N4A1B8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nuclear pore complex protein Nup98-Nup96</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PPYR_02896</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Nucleoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the nucleoporin GLFG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A1B8"/>
    <dbReference type="FunCoup" id="A0A5N4A1B8">
        <property type="interactions" value="2393"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A1B8"/>
    <dbReference type="OrthoDB" id="3797628at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044614">
        <property type="term" value="C:nuclear pore cytoplasmic filaments"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008139">
        <property type="term" value="F:nuclear localization sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000973">
        <property type="term" value="P:post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034398">
        <property type="term" value="P:telomere tethering at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1610.10">
        <property type="entry name" value="Peptidase S59, nucleoporin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037665">
        <property type="entry name" value="Nucleoporin_S59-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007230">
        <property type="entry name" value="Nup98_auto-Pept-S59_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036903">
        <property type="entry name" value="Nup98_auto-Pept-S59_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021967">
        <property type="entry name" value="Nup98_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23198:SF6">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP98-NUP96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23198">
        <property type="entry name" value="NUCLEOPORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04096">
        <property type="entry name" value="Nucleoporin2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12110">
        <property type="entry name" value="Nup96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82215">
        <property type="entry name" value="C-terminal autoproteolytic domain of nucleoporin nup98"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51434">
        <property type="entry name" value="NUP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="10" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peptidase S59" evidence="13">
        <location>
            <begin position="14"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="155"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAB0791096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="891" mass="100337" checksum="08A7284978B3E74E" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A1T6</accession>
    <name>A0A5N4A1T6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PPYR_03028</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">1611_PpyrPB1</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A1T6"/>
    <dbReference type="FunCoup" id="A0A5N4A1T6">
        <property type="interactions" value="296"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A1T6"/>
    <dbReference type="OrthoDB" id="504170at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14081">
        <property type="entry name" value="STKc_BRSK1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14340">
        <property type="entry name" value="UBA_BRSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000064">
        <property type="entry name" value="BR serine/threonine-protein kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000003">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048622">
        <property type="entry name" value="BRSK1_2-like_UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF36">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE BRSK1 ISOFORM X1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21122">
        <property type="entry name" value="KA1_BRSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21115">
        <property type="entry name" value="UBA_BRSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="7 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="19"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="362"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="693"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="761"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="362"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="376"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="396"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="409"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="481"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="707"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="761"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAB0791228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="803" mass="89320" checksum="80546821CFB487AF" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A1U4</accession>
    <name>A0A5N4A1U4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_03095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A1U4"/>
    <dbReference type="InParanoid" id="A0A5N4A1U4"/>
    <dbReference type="OrthoDB" id="6432525at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902936">
        <property type="term" value="F:phosphatidylinositol bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174">
        <property type="entry name" value="ALPHA-TOCOPHEROL TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174:SF213">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00180">
        <property type="entry name" value="CRETINALDHBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="118"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0791295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="298" mass="34476" checksum="90D6F400289B36D2" modified="2020-02-26" version="1">MTFSFVDVELQYEKVKGLRREDVAYLKEWLLRQPHLPQLRELDIMAFLQSCDFSIEMTKVTIDNYYTIKTFCREVFGPRDAEKVKTIVEHYQVVPLPEPTEEGYLILMSGLKNSNVGVYSFEDYGKAIDMVGRMTLYSRGVFNGVVIIFNTKNLTFGHLTKLNISLFRKYLVYLQEALPAQLKQIHVINTSSVIEKLLSIIRPFMKRELFDLIHVHSDYKATLFQHVRQALLPQDFGGSQRSTDDLHDEIATLVLENIDLIRVDEANLVDESKRLVRWTKSVGVFGVDGSFKQLELLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A2F6</accession>
    <name>A0A5N4A2F6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cns1/TTC4 wheel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_03279</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TTC4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A2F6"/>
    <dbReference type="FunCoup" id="A0A5N4A2F6">
        <property type="interactions" value="2282"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A2F6"/>
    <dbReference type="OrthoDB" id="420195at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21380">
        <property type="entry name" value="CTWD_Cns1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044059">
        <property type="entry name" value="Csn1/TTC4_wheel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46035">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46035:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18972">
        <property type="entry name" value="Wheel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Cns1/TTC4 wheel" evidence="4">
        <location>
            <begin position="260"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF18972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0791479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="368" mass="42681" checksum="D248D36D9E0ABFA4" modified="2020-02-26" version="1">MAKKFTDEERLALAAKLDKELDDFIDGLEKRPYTEGWPEDRWQEEMEKHPFFMKKMPEAGEPLDPLMEGLQQLKYDPNENTPEELANAYKDDGNFNFKHGNYRLAIIAYTEGLKIKCENAETNATLYNNRAAAHFFLKNYRSSLHDCKWALRLKPNYRKTLGRAAKCCLETRQFDQGIEYCDLLLGGDRTPEIVRLRQTIVNERKRQEKDSRKARRGEDRKADARRELMKAIGAAGVAFEGDLRPVVPELAECAVHLNDGRLVWPVIFTYPEYQVMDFIQEFDEYDTFREHLDRVFEESPAWDAESKYKVADLHVYLESSGKLQRFDIDSKLRDVLKCKGLLVKGGTPSFIILVGNSPAELAFLSRYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A323</accession>
    <name>A0A5N4A323_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PPYR_03501</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A323"/>
    <dbReference type="FunCoup" id="A0A5N4A323">
        <property type="interactions" value="32"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A323"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007517">
        <property type="term" value="P:muscle organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045663">
        <property type="term" value="P:positive regulation of myoblast differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19699">
        <property type="entry name" value="bHLH_TS_dMYOD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000005">
        <property type="entry name" value="Myogenic factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002546">
        <property type="entry name" value="MyoD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039704">
        <property type="entry name" value="Myogenic_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11534">
        <property type="entry name" value="MYOGENIC FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11534:SF9">
        <property type="entry name" value="MYOGENIC-DETERMINATION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01586">
        <property type="entry name" value="Basic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00520">
        <property type="entry name" value="BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="5">
        <location>
            <begin position="187"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="126"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="126"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="139"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="248"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0791701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="320" mass="35828" checksum="2837AFCDF762DB04" modified="2020-02-26" version="1">MCPSRFQKSQVFSFQFNKKTRARQCSVSIVGCLRIGRGTIKALLELPAVYSVSGRSSSDGNTMNVNFEPVANYVSRTSSYGAKLREKSLYAGVAPFFSGGEHRLKNAQTDYNANFFKCFESTKKRPGEKSKTAKRGGDEYDSADSSVDSDDEKELNHIFEPQSGNCGPRKCLTWACKACKKKTVTIDRRKAATLRERRRLRKVNEAFELLKRRSCNNPGQRLPKVEILRSAIEYIEYLEEVLQGSKGGSDPSSNPSTNSDYLNDHPQGYYNEKLHQFSEPLNKFSSANNFDLVSATSSLDCLNLIVQSIANPKIHEGEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A353</accession>
    <name>A0A5N4A353_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amine oxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_03555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A353"/>
    <dbReference type="InParanoid" id="A0A5N4A353"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046592">
        <property type="term" value="F:polyamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050281">
        <property type="entry name" value="Flavin_monoamine_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742:SF398">
        <property type="entry name" value="AMINE OXIDASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742">
        <property type="entry name" value="FLAVIN MONOAMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0791755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="270" mass="30314" checksum="31E887CB8049AD97" modified="2020-02-26" version="1">MEKSAKSITDKVLLNHVVKQVVRSDSKVEVKCTNGASFTSDHVIWTPSLGVLKRGYKTLFTPQLSGEKVQAIQTLGMNAVLKVGLYFPTKWWNDDFRGVVFSWAASDLQKSGEAFPYGPKTGNKSWITTIICVTSVPKSPNLLLAWLAGALVPEIEKTSDETITDGVIYTLREFMGEDYPNITRPDRVIRKNWYIDPHFHGTYSFETVESRKLGRPQAEVLGEPILSDEGKPILLFAGEATNPRHHSTVHGAIESGFREADRLIELYRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A3D3</accession>
    <name>A0A5N4A3D3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Odorant receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PPYR_03588</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cell membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A3D3"/>
    <dbReference type="FunCoup" id="A0A5N4A3D3">
        <property type="interactions" value="7"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A3D3"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU351113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0791788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="377" mass="43596" checksum="66FB19C613D794A9" modified="2020-02-26" version="1">MSERKSLNFGLLKLGVVGLDPRNQNWLTKIRAVVLSSILSLNYVLLVIEFFAKLTEIDALADTGEMLVSCHQCFTKMLTILITRPKIERLLEKLARFKDFATLDDELREDVTSTERRIHFVLKVYYHNARISAITMVFKPLIMKSRIFPIQVYNFIDLFQTPYYQIVYGFETLSIFYLFYIIIGFDITFFSIVTYIYNELKIIKYQFQHLKITESDLENGFKRLSEIIAHHDYVLSFISDLNTICSLLFLNQFLSAMMGICMSIFTIISHGLPMSIPFAVQHIVFIIGINLQLFLSCFAGALITSQALTVGNSIFYAPFWLDAPIWVKKKIIMVIQRSQKYETITVGKIYNIDLELYTIVLKASLSFLNAVIAFKQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A3H1</accession>
    <name>A0A5N4A3H1_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_03675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A3H1"/>
    <dbReference type="InParanoid" id="A0A5N4A3H1"/>
    <dbReference type="OrthoDB" id="8196554at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.30">
        <property type="entry name" value="Haemolymph juvenile hormone binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010562">
        <property type="entry name" value="Haemolymph_juvenile_hormone-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038606">
        <property type="entry name" value="To_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008:SF32">
        <property type="entry name" value="CIRCADIAN CLOCK-CONTROLLED PROTEIN DAYWAKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008">
        <property type="entry name" value="PROTEIN TAKEOUT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06585">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024395044" evidence="1">
        <location>
            <begin position="18"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0791875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="166" mass="18343" checksum="2C9D6C0C8E21E32A" modified="2020-02-26" version="1">MIVSVPLLFTLIIFCNAQLITKFQVCSRSDPNINSCLKSAVINALPVLKDGVNEYGLLSLEPIRLERFVVKAMPPTHFDQVYTNIELYGYMSSQIEEVTAQITDDSFSIAIRLLSGEGRVTSNYAFESAVFGGVDVSSAGQCSVTIVGKAVHDRVHFNSMFQLTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A3U8</accession>
    <name>A0A5N4A3U8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Heparan-alpha-glucosaminide N-acetyltransferase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_13948</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0791987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A3U8"/>
    <dbReference type="FunCoup" id="A0A5N4A3U8">
        <property type="interactions" value="579"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A3U8"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012429">
        <property type="entry name" value="HGSNAT_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31061">
        <property type="entry name" value="LD22376P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31061:SF24">
        <property type="entry name" value="LD22376P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07786">
        <property type="entry name" value="HGSNAT_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="273"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="316"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="426"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="460"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="494"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="Heparan-alpha-glucosaminide N-acetyltransferase catalytic" evidence="2">
        <location>
            <begin position="169"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0791987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="550" mass="61395" checksum="E7ACB262F84F7414" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A4M4</accession>
    <name>A0A5N4A4M4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alcohol dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_14235</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A4M4"/>
    <dbReference type="FunCoup" id="A0A5N4A4M4">
        <property type="interactions" value="119"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A4M4"/>
    <dbReference type="OrthoDB" id="417891at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229:SF8">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0792276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="267" mass="28612" checksum="5427C89B6117BDC3" modified="2020-02-26" version="1">MSLKEKYALVTGGARGIGFACVRELLLNGIEGVSLVDINVKKGKESTALLQSEFGPLKVLFLEADVSKKAEVRDAFRESVEHWGHLDLVINDAGMVSEQNWEPALLTNCGGALQGTLTGFQYMSTKQNGRGGTIVNVASIRGISPNMAMPVYSSTKAFTIMLGRSLGAPMYYDHNGVKVITVCPGKTTTELMLSSASLVASSGLHPNTQAVHVETLNGMKSQSPQEFAKLLMTVLDQAASGTVWAIAGNKVNQIDFSSMDQQCMLYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A4Q2</accession>
    <name>A0A5N4A4Q2_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutathione transferase</fullName>
            <ecNumber evidence="2">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PPYR_14240</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the GST superfamily. Sigma family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="2"/>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A4Q2"/>
    <dbReference type="FunCoup" id="A0A5N4A4Q2">
        <property type="interactions" value="320"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A4Q2"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03192">
        <property type="entry name" value="GST_C_Sigma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03039">
        <property type="entry name" value="GST_N_Sigma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000030">
        <property type="entry name" value="Glutathione S-transferase S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000035">
        <property type="entry name" value="hematopoietic prostaglandin D synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050213">
        <property type="entry name" value="GST_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571:SF224">
        <property type="entry name" value="HEMATOPOIETIC PROSTAGLANDIN D SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01205">
        <property type="entry name" value="AMPS.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00363">
        <property type="entry name" value="AMPS_(cytGST):_Alpha-__Mu-__Pi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="6">
        <location>
            <begin position="26"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="7">
        <location>
            <begin position="105"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0792281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="227" mass="25694" checksum="A09DC2138BBF504D" modified="2020-02-26" version="1">MVTFHLRLFIADTSGFGPISVLTMAPVYKLMYFPVKGIAEPIRFLLSYGNIEFEDHRFERENWPQIKPTTPFGQAPVLEFGGVKAYQSIAICRYLAKQVKLMGANDIEDLEIDAIIDTIADLRTKIAVYYKETDPTIKETRKKPLLEETIPYYMERIEAIAKKNNCHLAAGKLTWADVYFVASLDALNFLSGTNLIADCPSLQVMQDNVLNLPGIKEWVAKRPVTDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A6C7</accession>
    <name>A0A5N4A6C7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PPYR_14831</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A6C7"/>
    <dbReference type="InParanoid" id="A0A5N4A6C7"/>
    <dbReference type="OrthoDB" id="6339427at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000218">
        <property type="entry name" value="facilitated trehalose transporter Tret1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050549">
        <property type="entry name" value="MFS_Trehalose_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021:SF46">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="79"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="101"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="245"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="279"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="310"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="344"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="380"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="407"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="1"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0792872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="457" mass="50076" checksum="18BFD2393A55167F" modified="2020-02-26" version="1">MMLKGRQLQYFGTCLALLNMMGKGMHLAWPSPFLPILEGDPSTAITKDEGSWIATSYLISDPLGDIIISLLLNRIGRKYSLLVSAIPFLISWIIIAPTQRFGFIILARLIAGIGGGAIFTVLPIYIGELADPQIRGSLISLMVIVISVGALSINILGYYVTITHASIICALPSVLFLLLFPFLPETPNYYIVKGNMDKAREMLTKIRGKVVGDEEIKELVKNNEEGLVRAGVLDLFRVASNRKGLFIFMGTMTAQQVAGIVPIMYFYTQTIFIEAAADFPVIASTAILYLVLIVCSVISAALIDRLGRRPLLLTSTACCCLALLMEGVNLYLTGKGGGNSGFTWMTIGNISFLIVGYSIGLLTLPSIFMSELFPLNIKGVAVCFCNMFFSIMATTVTKLFQFTNDQYGLYVPFFVFSGLCFVTLVYVAISVPETKKKTLEQIQMELRVADGESKTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A6S3</accession>
    <name>A0A5N4A6S3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pacifastin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_12646</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A6S3"/>
    <dbReference type="InParanoid" id="A0A5N4A6S3"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024293320" description="Pacifastin domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0793026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="134" mass="15281" checksum="D3F5B756124C0CE1" modified="2020-02-26" version="1">MKTIAIVCLALFAVVLADKPTCKIGETKREDCAICDCLRLQDGSIDWYCTQYDCTHDEFLRKEPTCKIGETKHENCALCECMVFQNGIIDWFCTQGDCHFDDRSKTDTASKDTNHVDLLQRMFSMKTAHGILKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A894</accession>
    <name>A0A5N4A894_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">vitamin-K-epoxide reductase (warfarin-sensitive)</fullName>
            <ecNumber evidence="3">1.17.4.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PPYR_13163</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VKOR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.4" evidence="3"/>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A894"/>
    <dbReference type="FunCoup" id="A0A5N4A894">
        <property type="interactions" value="182"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A894"/>
    <dbReference type="OrthoDB" id="17010at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047057">
        <property type="term" value="F:vitamin-K-epoxide reductase (warfarin-sensitive) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042373">
        <property type="term" value="P:vitamin K metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12917">
        <property type="entry name" value="VKOR_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.130">
        <property type="entry name" value="VKOR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012932">
        <property type="entry name" value="VKOR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038354">
        <property type="entry name" value="VKOR_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042406">
        <property type="entry name" value="VKORC1/VKORC1L1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14519:SF8">
        <property type="entry name" value="VITAMIN K EPOXIDE REDUCTASE COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14519">
        <property type="entry name" value="VITAMIN K EPOXIDE REDUCTASE COMPLEX, SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07884">
        <property type="entry name" value="VKOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00756">
        <property type="entry name" value="VKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0874">Quinone</keyword>
    <keyword evidence="11" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="77"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Vitamin K epoxide reductase" evidence="13">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAB0793543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="161" mass="17953" checksum="E18ACF715AB6F4F3" modified="2020-02-26" version="1">MSGLNNVLTFVSLCGLGLSFYSYMVELSVEQDENYVASCDFSEHMSCTKAFKSEYGKGFGILGRVVGEDSVFNVPNSLYGILFYSFMATVAFSDSTLTTTIALGATILSNCSSVYFASILIFVLKDLCLVCVTIYVINLINLILIYIKWNRLREEEREKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A8U3</accession>
    <name>A0A5N4A8U3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Translocation protein SEC62</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PPYR_13354</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SEC62 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A8U3"/>
    <dbReference type="FunCoup" id="A0A5N4A8U3">
        <property type="interactions" value="1310"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A8U3"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031204">
        <property type="term" value="P:post-translational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004728">
        <property type="entry name" value="Sec62"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12443">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12443:SF9">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03839">
        <property type="entry name" value="Sec62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="184"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="71"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="251"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="82"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="114"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAB0793734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="329" mass="37910" checksum="C5CC16183601C1E4" modified="2020-02-26" version="1">MRKNVPIKKTKFLSHNVQYFTASKAIDALLDSNWSKGNDPLFKSREFIVDYLHTMLEHKFFHRARKVPVSEQELKGKRKEKKAIDSGDEKKEKAKEIEKEKKERGTDAESSVTEAKKEEGTDKEKRKRKIRLDMHNDQRFVDGLDAYVWIYDPIPFHYWIIGTLLVLGAIGVCLFPLWPPTVRLGVYYLSLAGAGFLVFIIVLAILRLIIFCLIWLLTLGKHHLWILPNLTEDVSFFASFWPLYTYEYKGPKPKKKEKDSDAEDEPDKKSDDDSSSKKKLLEDDRSGDGTNGQNRVEDVHDGSESESETSQRSSTGKDFEMVDQVDIDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-06-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A907</accession>
    <name>A0A5N4A907_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_13436</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A907"/>
    <dbReference type="InParanoid" id="A0A5N4A907"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.20">
        <property type="entry name" value="Pheromone/general odorant binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006170">
        <property type="entry name" value="PBP/GOBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036728">
        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01395">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024278675" evidence="1">
        <location>
            <begin position="20"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0793816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="145" mass="16815" checksum="371F33F1F37307F5" modified="2020-02-26" version="1">MKAHVLSLVFVWCIVQVLSVKFPEELIDDYIHECLEEHKLDKKVLDGYFDDSFRVVNLDDNGLKLTGCIVEKSNYYGPDGKFNKDVMTKDIEKWAKFLIKHEVEDYEALAAKLQGNCEKVNGKDRVEQLINWNNCLAGEFELLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AA24</accession>
    <name>A0A5N4AA24_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Acyl carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PPYR_13792</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">1611_PpyrPB1</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Carrier of the growing fatty acid chain in fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl carrier protein (ACP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0794172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AA24"/>
    <dbReference type="FunCoup" id="A0A5N4AA24">
        <property type="interactions" value="1592"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AA24"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000035">
        <property type="term" value="F:acyl binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000036">
        <property type="term" value="F:acyl carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.10:FF:000008">
        <property type="entry name" value="Acyl carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01217">
        <property type="entry name" value="Acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003231">
        <property type="entry name" value="ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002148">
        <property type="entry name" value="PRK00982.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20863">
        <property type="entry name" value="ACYL CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20863:SF28">
        <property type="entry name" value="ACYL CARRIER PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="13 14" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 14" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 14" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Carrier" evidence="15">
        <location>
            <begin position="105"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAB0794172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="184" mass="21320" checksum="303D18F47A582C47" modified="2020-02-26" version="1">MSTIARNFRSIAVRSLRIRSYSRPAIVGLQRLQSQNVDRPQTDLISKQYQARFYSPQIIKSKPSVKEIEERVIKVCCAYDKVTADKRLSVPLVRSYSAKPPLTLDFISERVLLVLRLYDKVDPCKLSLESHFMNDLGLDSLDHVEVIMAIEDEFGFEIPDMDAEKLHRPKDIVRYVADREDVYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ABE4</accession>
    <name>A0A5N4ABE4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Exosome RNA helicase MTR4</fullName>
            <ecNumber evidence="5">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="23">Superkiller viralicidic activity 2-like 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">TRAMP-like complex helicase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">PPYR_11489</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">1611_PpyrPB1</strain>
            <tissue evidence="27">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the helicase family. SKI2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="27">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="5"/>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0794650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ABE4"/>
    <dbReference type="FunCoup" id="A0A5N4ABE4">
        <property type="interactions" value="2482"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4ABE4"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18024">
        <property type="entry name" value="DEXHc_Mtr4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000083">
        <property type="entry name" value="ATP-dependent RNA helicase DOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000141">
        <property type="entry name" value="ATP-dependent RNA helicase DOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.300:FF:000001">
        <property type="entry name" value="Mtr4 exosome RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.30:FF:000002">
        <property type="entry name" value="superkiller viralicidic activity 2-like 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.30:FF:000004">
        <property type="entry name" value="Superkiller viralicidic activity 2-like 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025696">
        <property type="entry name" value="Beta-barrel_MTR4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048392">
        <property type="entry name" value="MTR4-like_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016438">
        <property type="entry name" value="SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012961">
        <property type="entry name" value="Ski2/MTR4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF7">
        <property type="entry name" value="EXOSOME RNA HELICASE MTR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08148">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21408">
        <property type="entry name" value="MTR4-like_stalk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13234">
        <property type="entry name" value="MTR4_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005198">
        <property type="entry name" value="Antiviral_helicase_SKI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01142">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0007">Acetylation</keyword>
    <keyword evidence="15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14" id="KW-0347">Helicase</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="18" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="10" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="16" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="25">
        <location>
            <begin position="213"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="26">
        <location>
            <begin position="442"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="106"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="108"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00049390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00069430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00077324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00082023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="KAB0794650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1115" mass="126712" checksum="AB7BE1B92C5308E6" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AC60</accession>
    <name>A0A5N4AC60_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Disease resistance R13L4/SHOC-2-like LRR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_11718</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0794879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AC60"/>
    <dbReference type="FunCoup" id="A0A5N4AC60">
        <property type="interactions" value="972"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AC60"/>
    <dbReference type="OrthoDB" id="660555at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000116">
        <property type="entry name" value="Leucine-rich repeat-containing protein 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000193">
        <property type="entry name" value="Leucine-rich repeat-containing protein 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF1">
        <property type="entry name" value="RAS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Disease resistance R13L4/SHOC-2-like LRR" evidence="3">
        <location>
            <begin position="469"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0794879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="604" mass="68784" checksum="F37F948CEB6548F1" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AC82</accession>
    <name>A0A5N4AC82_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Putative nuclease HARBI1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Harbinger transposase-derived nuclease</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PPYR_11763</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Transposase-derived protein that may have nuclease activity. Does not have transposase activity.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HARBI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0794924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AC82"/>
    <dbReference type="InParanoid" id="A0A5N4AC82"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026103">
        <property type="entry name" value="HARBI1_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF85">
        <property type="entry name" value="GH03217P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02086">
        <property type="entry name" value="PUTNUCHARBI1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="13">
        <location>
            <begin position="182"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAB0794924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="356" mass="41557" checksum="9758D27995E37D1D" modified="2020-02-26" version="1">MEKLVLMELSRSLSPLISASSSSDDDINITTQRRKRIRIMHYMDTITSYSDEEFKQHFRLKRETALKLIGIHTSIPFPYFILDLLELYRSSIKAYKGGWNHITAEKAIYITIWYLSNMETFRQISDRFDVTLSCAHHVINVVLDFLVNNSSKFIKWPSEQEAKEEAYYFEKKKGIANVIGAIDGCHIKIHRPVIHEQDYVNRKGYHSIILQGVVDSKMKFIDISTGHPGSVHDARVLRKSYMYNAAVENYQTTFFNKYRLVGDSAYPSLKWLVVPYKDNGHLSDEQRDYNYRHSVTRIIVEHAFGALKGRFRRLRYFENLKLTFIIKCVVAACVLHNICLMGNDITEKIYDDEINE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AFM5</accession>
    <name>A0A5N4AFM5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_10160</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AFM5"/>
    <dbReference type="InParanoid" id="A0A5N4AFM5"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00084">
        <property type="entry name" value="HMG-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="3">
        <location>
            <begin position="15"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="1">
        <location>
            <begin position="15"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="51"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0796099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="123" mass="14327" checksum="77FCD46938F9717E" modified="2020-02-26" version="1">MSKIFDRKMSGGNPEKVTRNAYLNFFLQLRAENRDKPIKEVASMAGACWREMPPDEKKPYKSMAESAPFVFRRRRKRLARSRDGSIGHGGRRHRTRDHGRGHHGSGRHHSRSESRSNRRKRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-06-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AFZ4</accession>
    <name>A0A5N4AFZ4_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_10331</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AFZ4"/>
    <dbReference type="InParanoid" id="A0A5N4AFZ4"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0796270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="102" mass="11854" checksum="CA18BCC41B95C0D7" modified="2020-02-26" version="1">MHICNLLRFDQSCSYTVLCRNLDHCLNTLFKQCLDSITTVTSRTTKKLPSGPGLRNVVLSKNAENIVDEQDNVQVLQDMHKDMWDLVKFIRKCKYRQPKVPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AGY7</accession>
    <name>A0A5N4AGY7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_10673</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AGY7"/>
    <dbReference type="InParanoid" id="A0A5N4AGY7"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33939:SF1">
        <property type="entry name" value="DUF4371 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33939">
        <property type="entry name" value="PROTEIN CBG22215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0796612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="222" mass="25469" checksum="0009ECFBC6F9AE4A" modified="2020-02-26" version="1" fragment="single">KHVTVAALNAEIKNSHVLLSDRSLNRAVHALRFKFKKDSNRRALIEKPNIAEMRTKFLRQYMQEIRSSSRRPIAFMDETWIYSKGNPGKSWQDEDLKSVRKPAGYDGKRFIIVHAGTSTGFIQNASLLFASKSLKEDYHGEMNGDLFKKWLINNLLNNLEEPSLIVIDNAPYHSTLVEKLPTSSWTKGDMVAWLTRRNIPFDSTLFKPELCSESSDYDSDTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AH08</accession>
    <name>A0A5N4AH08_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Intraflagellar transport protein 122 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PPYR_10640</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AH08"/>
    <dbReference type="FunCoup" id="A0A5N4AH08">
        <property type="interactions" value="427"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AH08"/>
    <dbReference type="OrthoDB" id="10255582at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030991">
        <property type="term" value="C:intraciliary transport particle A"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097730">
        <property type="term" value="C:non-motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035721">
        <property type="term" value="P:intraciliary retrograde transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061512">
        <property type="term" value="P:protein localization to cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000176">
        <property type="entry name" value="Intraflagellar transport protein 122 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056153">
        <property type="entry name" value="Beta-prop_IFT122_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056152">
        <property type="entry name" value="Beta-prop_IFT122_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039857">
        <property type="entry name" value="Ift122/121"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057411">
        <property type="entry name" value="TPR_IFT122"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056838">
        <property type="entry name" value="Zn_ribbon_IFT122"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12764:SF4">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 122 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12764">
        <property type="entry name" value="WD REPEAT DOMAIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23381">
        <property type="entry name" value="Beta-prop_IFT122_1st"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23377">
        <property type="entry name" value="Beta-prop_IFT122_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25295">
        <property type="entry name" value="TPR_IFT122"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25144">
        <property type="entry name" value="Zn_ribbon_IFT122"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25143">
        <property type="entry name" value="Zn_ribbon_IFT122_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0969">Cilium</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="IFT122 first beta-propeller" evidence="9">
        <location>
            <begin position="14"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="55"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="IFT122 first beta-propeller" evidence="9">
        <location>
            <begin position="195"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="IFT122 second beta-propeller" evidence="8">
        <location>
            <begin position="302"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="Intraflagellar transport protein 122 homolog TPR" evidence="11">
        <location>
            <begin position="564"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="domain" description="IFT122 zinc ribbon" evidence="10">
        <location>
            <begin position="995"/>
            <end position="1037"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF23377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF25144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF25295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAB0796579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1187" mass="135064" checksum="3F32E49BE3A4210B" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AH19</accession>
    <name>A0A5N4AH19_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Conserved oligomeric Golgi complex subunit 6</fullName>
            <shortName evidence="11">COG complex subunit 6</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Component of oligomeric Golgi complex 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PPYR_10703</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">1611_PpyrPB1</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Required for normal Golgi function.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the conserved oligomeric Golgi complex which is composed of eight different subunits and is required for normal Golgi morphology and localization.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Golgi apparatus membrane</location>
            <topology evidence="2 11">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the COG6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AH19"/>
    <dbReference type="FunCoup" id="A0A5N4AH19">
        <property type="interactions" value="1080"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AH19"/>
    <dbReference type="OrthoDB" id="272987at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010490">
        <property type="entry name" value="COG6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048369">
        <property type="entry name" value="COG6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048368">
        <property type="entry name" value="COG6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21506">
        <property type="entry name" value="COMPONENT OF OLIGOMERIC GOLGI COMPLEX 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21506:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20653">
        <property type="entry name" value="COG6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06419">
        <property type="entry name" value="COG6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01087">
        <property type="entry name" value="COG6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Conserved oligomeric complex COG6 N-terminal" evidence="13">
        <location>
            <begin position="36"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Conserved Oligomeric Golgi complex subunit 6 C-terminal" evidence="14">
        <location>
            <begin position="184"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="84"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF06419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF20653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAB0796642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="624" mass="71145" checksum="9CD03629A5CD0734" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AI99</accession>
    <name>A0A5N4AI99_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Carbonic anhydrase</fullName>
            <ecNumber evidence="3 8">4.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PPYR_11102</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Reversible hydration of carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>hydrogencarbonate + H(+) = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the alpha-carbonic anhydrase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="3 8"/>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0797041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AI99"/>
    <dbReference type="InParanoid" id="A0A5N4AI99"/>
    <dbReference type="OrthoDB" id="429145at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00326">
        <property type="entry name" value="alpha_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.200.10">
        <property type="entry name" value="Alpha carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001148">
        <property type="entry name" value="CA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036398">
        <property type="entry name" value="CA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023561">
        <property type="entry name" value="Carbonic_anhydrase_a-class"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018338">
        <property type="entry name" value="Carbonic_anhydrase_a-class_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952:SF265">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00194">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01057">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51069">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00162">
        <property type="entry name" value="ALPHA_CA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51144">
        <property type="entry name" value="ALPHA_CA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alpha-carbonic anhydrase" evidence="9">
        <location>
            <begin position="1"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0797041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="202" mass="22913" checksum="2445CB01C92ADDF2" modified="2020-02-26" version="1">MPESMMLASDGHSLKLTVESSMPLNLKAPLTSVPYEFNHIHFHWGDGEDNNKGSEHYVNGHFYPLEMHAVHTQSVSNTTDKFLVVAYLFQLSRQKNPVMEKIVDAILDATINGNGTVENFKLINLLYNIPFSYFTYEGSLTTPPYTESVVFLVAATHFPITKHQLEAFQQAASINPGLRNNYRCLQDTNHRKVMHVLLPSYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AIK0</accession>
    <name>A0A5N4AIK0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PPYR_08117</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">1611_PpyrPB1</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Microsome membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 15">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AIK0"/>
    <dbReference type="InParanoid" id="A0A5N4AIK0"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20628">
        <property type="entry name" value="CYP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
        <property type="entry name" value="Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291:SF189">
        <property type="entry name" value="CYTOCHROME P450 4C3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 14 15" id="KW-0349">Heme</keyword>
    <keyword evidence="11 14 15" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0492">Microsome</keyword>
    <keyword evidence="12 15" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="10 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="14">
        <location>
            <position position="431"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAB0797123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="484" mass="55637" checksum="AC95EDDDDBF04DD0" modified="2020-02-26" version="1">MFVWAFLVIVSFWFVHHHWTRRKLYTLAAKIPGPRAYPLIGSAYLFFSFKDIAQNASKIMEKYGSILKIWMFNALVVVVAKPKHVQIILTKCLEKETRYKFAKDAFGNSLLTAPVATWRSHRKTINPAFSQQILDSFVDIFVKHSQILVRKLEEEVDDQKTFDVHEHLSRCSLDIICETAMGTTVDAQTKPSKLLHATRRGAQILVERCVRLWLHPNITFRLSQRGRELKEVLDYVQGYTGNLVRKRYEEFHSRIDDNFRDTSRKPFLEHLLSLGDQMTFLELRNEVDLFITAGSDTVTTTTGYVLVCLGMYQHIQQEIIQEIDEIFGISTRPITRDDLPKLKYMERVIKETMRLYPPVPLIARSVTEDIDLGELILPAGCSVVVGIIGMHRDPETWTDPLKFDPDRFTSEEAAKRHPYSYIPFSGGPRNCIGIKFSMMAVKVLLATILRSYKIHTDIKPQDIKLSVEIVSKMIGGANISISKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AJ55</accession>
    <name>A0A5N4AJ55_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_08345</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AJ55"/>
    <dbReference type="InParanoid" id="A0A5N4AJ55"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070531">
        <property type="term" value="C:BRCA1-A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031436">
        <property type="term" value="C:BRCA1-BARD1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0085020">
        <property type="term" value="P:protein K6-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF9">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="135"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="169"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="202"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0797351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="255" mass="28228" checksum="FC9C06A87373ED0A" modified="2020-02-26" version="1">MSLFTPDPSFVYIAVKASLHAKATAVFGLNKQEEIALSKRFDNHSQEIINGVLLKGAPIQIVNALAELGYRFKMSNCEHSCDNAKHTCVRHSSLSQTLDELDFERGVWPAAQFGDLKKVQKLINNGVDVDLRDSAGYTSLHYAARNGHLDVCKFLIQSKADINAVTRSGRVTALHRACTAGQLDVVNFLIECKANIAIRDSDGKTVLHRAAQANHLEISKILTSAYPELKLIKDNKGKLPEDYIINEAIRELFNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AK01</accession>
    <name>A0A5N4AK01_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Coatomer subunit beta'</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PPYR_08678</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">1611_PpyrPB1</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cytoplasmic vesicle</location>
            <location evidence="1 12">COPI-coated vesicle membrane</location>
            <topology evidence="1 12">Peripheral membrane protein</topology>
            <orientation evidence="1 12">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Golgi apparatus membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Cytoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="12">The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the WD repeat COPB2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AK01"/>
    <dbReference type="FunCoup" id="A0A5N4AK01">
        <property type="interactions" value="2151"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AK01"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22947">
        <property type="entry name" value="Coatomer_WDAD_beta-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.470:FF:000001">
        <property type="entry name" value="Coatomer subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006692">
        <property type="entry name" value="Beta-prop_COPA/B_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050844">
        <property type="entry name" value="Coatomer_complex_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016453">
        <property type="entry name" value="COPB2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056176">
        <property type="entry name" value="TPR_COPA_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876">
        <property type="entry name" value="COATOMER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876:SF2">
        <property type="entry name" value="COATOMER SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04053">
        <property type="entry name" value="B-prop_COPA_B_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23953">
        <property type="entry name" value="TPR_COPA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005567">
        <property type="entry name" value="Coatomer_beta'_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 12" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7 12" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <keyword evidence="5 13" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="24"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="67"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="111"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B second beta-propeller" evidence="15">
        <location>
            <begin position="206"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B TPR" evidence="16">
        <location>
            <begin position="481"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="763"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="778"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="794"/>
            <end position="810"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR005567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF23953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAB0797685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="810" mass="90461" checksum="62EE1FFEF081C892" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AKE0</accession>
    <name>A0A5N4AKE0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">GPI mannosyltransferase 2</fullName>
            <ecNumber evidence="11">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PPYR_08759</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the PIGV family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="11"/>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AKE0"/>
    <dbReference type="FunCoup" id="A0A5N4AKE0">
        <property type="interactions" value="543"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AKE0"/>
    <dbReference type="OrthoDB" id="10252502at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031501">
        <property type="term" value="C:mannosyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004376">
        <property type="term" value="F:GPI mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007315">
        <property type="entry name" value="PIG-V/Gpi18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12468">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12468:SF2">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04188">
        <property type="entry name" value="Mannosyl_trans2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4 11" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="335"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="390"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="457"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAB0797766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="480" mass="56503" checksum="D9EC27B91F6C8EB4" modified="2020-02-26" version="1">MYKKRIILFAIITRTLIIILQFFSNLLIPDHDAGVFTYPRLSSNQSTYDVWVQTSLGGFLRWDAQYFMHIAKYGYTHENTLAFFPLYPLIVRIIASLTSYFITFLNEDSLLLISFIFVNIVVFTKASVELYKLTAVVLNVDLAYKSAMLFCINPASIFFVAPYTECLFSYLTFKSMLHCVFIFDKYNRKLNNYMKIIVPTSLSACIRSNGVLNIGFLIYFMVQDGIRNITAPKSLVMKLFTCFKNGILIICAIYLCLIPFVLTQYYFYQQFCTDFQHNLPVFLIDFIHSNDYVFPGMRSYYNQSWCLDKIPLAYSYIQSHYWNVGFLKYFECKQIPNFLLAAPIVLFLMYNNCKFFAMHKRYCLNLGIFNFNFSTSREKSKTVSTFKPKMFVFIVHETFLIIFCVFCIHVQVTTRMLCSASPVLYWFAAYSFKYIKEHDSGIRNMFLFQKHDFTQRLILYYFIGYVVIGTVMFTNFLPWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AKK5</accession>
    <name>A0A5N4AKK5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Multidrug resistance-associated protein lethal(2)03659</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PPYR_08840</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AKK5"/>
    <dbReference type="InParanoid" id="A0A5N4AKK5"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000973">
        <property type="entry name" value="Multidrug resistance-associated protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000014">
        <property type="entry name" value="Multidrug resistance-associated protein member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000163">
        <property type="entry name" value="Multidrug resistance-associated protein member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF448">
        <property type="entry name" value="FI20146P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="110"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="543"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="610"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="793"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="820"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="1"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="289"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="555"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="883"/>
            <end position="1116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAB0797847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1125" mass="125730" checksum="E29DFD1148A781E7" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2024-05-29" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AL00</accession>
    <name>A0A5N4AL00_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HORMA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_08891</name>
        <name evidence="3" type="ORF">PPYR_08895</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AL00"/>
    <dbReference type="InParanoid" id="A0A5N4AL00"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016035">
        <property type="term" value="C:zeta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.10">
        <property type="entry name" value="HORMA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003511">
        <property type="entry name" value="HORMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045091">
        <property type="entry name" value="Mad2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11842">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11842:SF10">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02301">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56019">
        <property type="entry name" value="The spindle assembly checkpoint protein mad2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50815">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HORMA" evidence="1">
        <location>
            <begin position="7"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0797898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0797902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="105" mass="12308" checksum="C516F7EEB42CAA4B" modified="2020-02-26" version="1">MNSKADEIIVNILCEFCEVVIHNILYLRQLYPKQIFVKRKKYGVIVHRSVHPQLNEYITESLKAVKYHAKACSLRKLFVCIIGAEATIHERFVFDILSIQNNFNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AL49</accession>
    <name>A0A5N4AL49_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glycosyltransferase family 92 protein</fullName>
            <ecNumber evidence="8">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_08941</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyltransferase 92 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="8"/>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AL49"/>
    <dbReference type="InParanoid" id="A0A5N4AL49"/>
    <dbReference type="OrthoDB" id="6433308at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008166">
        <property type="entry name" value="Glyco_transf_92"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21461:SF87">
        <property type="entry name" value="GH12965P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21461">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01697">
        <property type="entry name" value="Glyco_transf_92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0797948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="397" mass="46331" checksum="436FE0510E0B62F8" modified="2020-02-26" version="1">MKKYRQLLLLIITVVSVSLLLVYRHEYNRLHYVLEVFNFFGKPCNISSLETSENVLGYHDWGPESLWQETENIYIYSAFWNKDYEAQAIVLHTGKAEVAKSCYLWFEDKEKPTPGKFRYAEVENDKVNGQTAFFYYCSLTTTLHKPYAVSFAVKNKKIGELKKVHLTVSRAHTQKVNTVICVSPTDFNKSFFVEFLSYHKLVGVENFIFYQSNIPHRLIKIVHNLSNRLGINTHFRSWNFPKTEGALSRTIVEKDCILRTANYSDNSITLELNEFIVPSGHFIYFNETFNASKKMPDRISLPVQTFCVDNSARRKPITLQNVDVSYNNDNKVRYVYRLFSEQSVVVTHAVVKDVISIHKYIRCTQKPVRVYRDSSMLRFSVDLTRSTLVQLYLHNDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ALD5</accession>
    <name>A0A5N4ALD5_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PPYR_09120</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4ALD5"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18579">
        <property type="entry name" value="ABC_6TM_ABCC_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000026">
        <property type="entry name" value="Multidrug resistance-associated protein lethal(2)03659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000014">
        <property type="entry name" value="Multidrug resistance-associated protein member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000163">
        <property type="entry name" value="Multidrug resistance-associated protein member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000482">
        <property type="entry name" value="Multidrug resistance-associated protein member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044746">
        <property type="entry name" value="ABCC_6TM_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF415">
        <property type="entry name" value="FI20190P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="318"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="353"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="687"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="780"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="854"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="965"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="99"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="417"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="770"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="1059"/>
            <end position="1287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0798127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1311" mass="148332" checksum="906F99EAB62EBAF0" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ALR1</accession>
    <name>A0A5N4ALR1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transmembrane protein 198</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_09250</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM198 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ALR1"/>
    <dbReference type="FunCoup" id="A0A5N4ALR1">
        <property type="interactions" value="123"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4ALR1"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025256">
        <property type="entry name" value="TM7S3/TM198-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040236">
        <property type="entry name" value="TMEM198"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31247:SF5">
        <property type="entry name" value="DUF4203 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31247">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 198 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13886">
        <property type="entry name" value="TM7S3_TM198"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="TM7S3/TM198-like" evidence="8">
        <location>
            <begin position="51"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0798257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="352" mass="38313" checksum="EBFC6CE5DF393593" modified="2020-02-26" version="1">MEGGARPGSLVPPRNNSTLGVLPGLRIPDGPKVEHCNRIDTDYNLTTAAICSVYVVFGILYTFFGYRCFKTVMFLTGFIFASSLVYLICLQGELMPPYGNAGVALLAGFLFGLITMLVQYVGLFMSGLHTGLLLGLAALLAADHILETSPKGSVWLCVGVLLVSALIFAVLNLYFRKGLTILGTSVYGGAIISVAADYFLERVAMVFWVWQRVSLRPVAPAPCWFSWIVLGIWPALVCAGLIIQFSLTGRGTYHADLFAGRKKPRSSSAHRGQTRVDKAELRQKKYRYLYQVRTAHGDVISQALQKKDPGGAPGECSTLQSDATHLTILPDAQLAALTESEDDSQTEIPTQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AN03</accession>
    <name>A0A5N4AN03_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Haemolymph juvenile hormone binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_09677</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AN03"/>
    <dbReference type="InParanoid" id="A0A5N4AN03"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007623">
        <property type="term" value="P:circadian rhythm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.15.10.30:FF:000001">
        <property type="entry name" value="Takeout-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.30">
        <property type="entry name" value="Haemolymph juvenile hormone binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010562">
        <property type="entry name" value="Haemolymph_juvenile_hormone-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038606">
        <property type="entry name" value="To_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008:SF39">
        <property type="entry name" value="CIRCADIAN CLOCK-CONTROLLED PROTEIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008">
        <property type="entry name" value="PROTEIN TAKEOUT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06585">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00700">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0090">Biological rhythms</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00060902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0798684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="260" mass="29541" checksum="75B246DBFFC462BE" modified="2020-02-26" version="1">MTLPRFRFVSRCEMHKVAQLVTICVLIVDVNSKIPDYIKVCPNNHPNLAECIKNSILELLPVLKIGIPELNIPPLEPLELDRMSFKSGSDAANLATNLTDLQVWGASSFHILHLSVGNTKTGRSFRFKVEVPHLYGIGNYQINTKLLFLDLQGEGKFYTNVSNYRFDCTLNGNIIQNDGRNHLLFEKLICKLRIGEKKLRLDNLFAQNPILAEATKGIIDDNTEVFFNEIRPGLQDSLDQKFTDLANRITMAFTYEELFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-06-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4APS2</accession>
    <name>A0A5N4APS2_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_07181</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4APS2"/>
    <dbReference type="InParanoid" id="A0A5N4APS2"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0799301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="109" mass="11604" checksum="4FA2BE420444FF4B" modified="2020-02-26" version="1">MEIAHVPLDTATATVDQPRVANVKPNAAQVQKNANVPQAALALVGTTVPVRIANAKVVVNDPILMGVLARVLNATILVCLMNSLLFISCNNPKAELVYQANTNCITRFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AQM0</accession>
    <name>A0A5N4AQM0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">ATP-citrate synthase</fullName>
            <ecNumber evidence="23">2.3.3.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="23">ATP-citrate (pro-S-)-lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="23">Citrate cleavage enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="29" type="ORF">PPYR_07535</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="29 30" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="29">1611_PpyrPB1</strain>
            <tissue evidence="29">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="22">Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate in multiple biochemical reactions in protein, carbohydrate and lipid metabolism.</text>
    </comment>
    <comment type="function">
        <text evidence="19">Catalyzes the formation of cytosolic acetyl-CoA, which is mainly used for the biosynthesis of fatty acids and sterols.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18 23">
            <text>oxaloacetate + acetyl-CoA + ADP + phosphate = citrate + ATP + CoA</text>
            <dbReference type="Rhea" id="RHEA:21160"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.3.3.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="21">Composed of two subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 23">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="20">Belongs to the succinate/malate CoA ligase alpha subunit family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 23">In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 23">In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="29">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.8" evidence="23"/>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AQM0"/>
    <dbReference type="FunCoup" id="A0A5N4AQM0">
        <property type="interactions" value="1730"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AQM0"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003878">
        <property type="term" value="F:ATP citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006085">
        <property type="term" value="P:acetyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006101">
        <property type="term" value="P:citrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06100">
        <property type="entry name" value="CCL_ACL-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000003">
        <property type="entry name" value="ATP-citrate synthase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000004">
        <property type="entry name" value="ATP-citrate synthase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.230.10:FF:000005">
        <property type="entry name" value="ATP-citrate synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.110:FF:000003">
        <property type="entry name" value="ATP-citrate synthase subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000024">
        <property type="entry name" value="Probable ATP-citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="entry name" value="Citrate Synthase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="entry name" value="Cytochrome P450-Terp, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014608">
        <property type="entry name" value="ATP-citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017440">
        <property type="entry name" value="Cit_synth/succinyl-CoA_lig_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032263">
        <property type="entry name" value="Citrate-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056749">
        <property type="entry name" value="Citrate_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033847">
        <property type="entry name" value="Citrt_syn/SCS-alpha_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017866">
        <property type="entry name" value="Succ-CoA_synthase_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="SUCC_ACL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23118">
        <property type="entry name" value="ATP-CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23118:SF42">
        <property type="entry name" value="ATP-CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16114">
        <property type="entry name" value="Citrate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24948">
        <property type="entry name" value="Citrate_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036511">
        <property type="entry name" value="ATP_citrt_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01216">
        <property type="entry name" value="SUCCINYL_COA_LIG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00399">
        <property type="entry name" value="SUCCINYL_COA_LIG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01217">
        <property type="entry name" value="SUCCINYL_COA_LIG_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0007">Acetylation</keyword>
    <keyword evidence="13 23" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 23" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8 23" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="17 23" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14 23" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 23" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 23" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 23" id="KW-0808">Transferase</keyword>
    <keyword evidence="15" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="ATP-citrate synthase ATP-grasp" evidence="28">
        <location>
            <begin position="2"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-citrate synthase citrate-binding" evidence="27">
        <location>
            <begin position="243"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="CoA-binding" evidence="26">
        <location>
            <begin position="480"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-citrate synthase/succinyl-CoA ligase C-terminal" evidence="25">
        <location>
            <begin position="644"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="24">
        <location>
            <position position="744"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00054002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00060724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00062455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00093367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PIRNR" id="PIRNR036511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PIRSR" id="PIRSR036511-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF00549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF02629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="Pfam" id="PF16114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="Pfam" id="PF24948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="EMBL" id="KAB0799655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1085" mass="119421" checksum="5AF3AFAE1AA58471" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ARB3</accession>
    <name>A0A5N4ARB3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SCP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_07772</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ARB3"/>
    <dbReference type="FunCoup" id="A0A5N4ARB3">
        <property type="interactions" value="69"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4ARB3"/>
    <dbReference type="OrthoDB" id="414826at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd05380">
        <property type="entry name" value="CAP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018244">
        <property type="entry name" value="Allrgn_V5/Tpx1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002413">
        <property type="entry name" value="V5_allergen-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00838">
        <property type="entry name" value="V5ALLERGEN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01009">
        <property type="entry name" value="CRISP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01010">
        <property type="entry name" value="CRISP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024381259" description="SCP domain-containing protein" evidence="3">
        <location>
            <begin position="21"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="4">
        <location>
            <begin position="59"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0799892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="274" mass="30996" checksum="554725CB858E2CFE" modified="2020-02-26" version="1">MMEHWLHIFVTTALASVCLANYFCNLPCEKDENTVCRRKPCGCSERCGVHFRMLPIDGGARKVLIDLHNKYRSTIANGYSIPGTSIKLPSATDMIRLNYDQELEFVAQCYANACMEWGAHDKCRRTSKFQAAGQNMYTTYGSGNFNFSDEKYIEEAVTSWFNEVKDMEPDVVNSYRPTGKVIGHFTQLAWARTSHIGCARTMYGNRNIKGMYLYCNYGPGGNILGGTMYQAGSPGDSCSIRSETYKNLCVHSNKVTEHEGDDWEDWEPPFPILE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ARW7</accession>
    <name>A0A5N4ARW7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Polyglutamylase complex subunit TTLL1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Tubulin polyglutamylase TTLL1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Tubulin polyglutamylase complex subunit 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Tubulin--tyrosine ligase-like protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PPYR_07972</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">1611_PpyrPB1</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(L-glutamyl)(n)-gamma-L-glutamyl-L-glutamyl-[protein] + L-glutamate + ATP = (L-glutamyl)(n+1)-gamma-L-glutamyl-L-glutamyl-[protein] + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60148"/>
            <dbReference type="Rhea" id="RHEA-COMP:15519"/>
            <dbReference type="Rhea" id="RHEA-COMP:15675"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:143623"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:60149"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Part of the neuronal tubulin polyglutamylase complex which contains TPGS1, TPGS2, TTLL1, LRRC49 and NICN1. Interacts with PCM1, CSTPP1 and LRRC49.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tubulin polyglutamylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0800092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ARW7"/>
    <dbReference type="FunCoup" id="A0A5N4ARW7">
        <property type="interactions" value="47"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4ARW7"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070740">
        <property type="term" value="F:tubulin-glutamic acid ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000033">
        <property type="entry name" value="Probable tubulin polyglutamylase TTLL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004344">
        <property type="entry name" value="TTL/TTLL_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12241:SF31">
        <property type="entry name" value="POLYGLUTAMYLASE COMPLEX SUBUNIT TTLL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12241">
        <property type="entry name" value="TUBULIN POLYGLUTAMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03133">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51221">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00052959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00062645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00074800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00075351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00080021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00083073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAB0800092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="285" mass="32911" checksum="4828A42D1299F31B" modified="2020-02-26" version="1">MFVEEYRKAPQSTWIMKPCGKSQGLGIFLINKLSKLKRWSREANKNPLQPQLSRECYVISRYINNPLLIGGKKFDLRLYVIVTSFRPLKAYQFKLGFCRFCTVKYDTSVAELDNMFVHLTNVAVQKHGDEYNSLHGGKLSVQNLRLHLESTRGKETTEKLFDEISWLIIHSLKAVQPVMATDRHCFECYGYDIIIDNKLKPWLIEVNASPSLTSTTANDRILKHKLIDNILSLVLPPSGHPDVRWNKIVAPETLGDFELLIDEDLVNQEDGCSDRHNNKSNYRWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ARX4</accession>
    <name>A0A5N4ARX4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Histone deacetylase 8</fullName>
            <ecNumber evidence="6">3.5.1.98</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Protein deacetylase HDAC8</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Protein decrotonylase HDAC8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">PPYR_07954</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">1611_PpyrPB1</strain>
            <tissue evidence="25">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>N(6)-(2E)-butenoyl-L-lysyl-[protein] + H2O = (2E)-2-butenoate + L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:69172"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:13707"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:35899"/>
            <dbReference type="ChEBI" id="CHEBI:137954"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:69173"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>N(6)-acetyl-L-lysyl-[histone] + H2O = L-lysyl-[histone] + acetate</text>
            <dbReference type="Rhea" id="RHEA:58196"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="3.5.1.98"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:58197"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>N(6)-acetyl-L-lysyl-[protein] + H2O = L-lysyl-[protein] + acetate</text>
            <dbReference type="Rhea" id="RHEA:58108"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:58109"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the histone deacetylase family. HD type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="6"/>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0800074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ARX4"/>
    <dbReference type="InParanoid" id="A0A5N4ARX4"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003084">
        <property type="entry name" value="HDAC_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF14">
        <property type="entry name" value="HISTONE DEACETYLASE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037913">
        <property type="entry name" value="His_deacetylse_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01271">
        <property type="entry name" value="HISDACETLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="7" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 23" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0678">Repressor</keyword>
    <keyword evidence="14" id="KW-0804">Transcription</keyword>
    <keyword evidence="13" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="24">
        <location>
            <begin position="21"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="22">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00040347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00041964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00042783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00049193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00049416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="KAB0800074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="300" mass="33365" checksum="76151A4AF5F8D4CB" modified="2020-02-26" version="1">MEKKVIYIYDSTLRDECDRLPTVPGRASIVTDLVNSYELLKSGNVTVVPSIPATYDELRLFHSSAYLDFMKAYKEDDVGFEDGEEDEFGLSYDCPLLPRLYTLVQALAGGSITAANLLAERKCDFAINWFGGWHHAQRDEAEGFCYVNDIVIAIQTLTRSFTKILYVDLDVHHGNGVQNAFELSSKILTLSFHKYSPGFYPGGGNVDEVGSRRGKYFSLNVPLRDGCSGKTYLRCFKEIFPRVFRAFKPSALVVQCGADCINGDPVGQINITTKDMGECIKDVLNCNVPTLFLGGGRLLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-06-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ASC4</accession>
    <name>A0A5N4ASC4_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_05956</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000004">
        <property type="protein sequence ID" value="KAB0800216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ASC4"/>
    <dbReference type="InParanoid" id="A0A5N4ASC4"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024387091" evidence="1">
        <location>
            <begin position="30"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0800216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="290" mass="30805" checksum="E70B75B1B5AA835C" modified="2020-02-26" version="1">MNHYQQPTTQSTMSLTILLLVAFASLANAGFLESVPAALRLSVSQPAPALSLVSPAITRTEYTPGSYSSSYRSDVITPRVKYTETPGVRITVPQPSIAIAPAVARVEHVLPAFERIAVPTVARVEPLIAAPAVAKFEHITPVERIEKIAPALQPLIASPAVARFEHLALPTAVERIEKVVAPLPTIARFEHVAAAPLLEARTITSLPTISKVEHFAPSIARVDRLTTAPLLSETLHRIATPAIAKTFALGTAAPLLRSELVAPAAFGYGIAGFGAREIALGHGVHYKSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ASL2</accession>
    <name>A0A5N4ASL2_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PPYR_06074</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000004">
        <property type="protein sequence ID" value="KAB0800334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ASL2"/>
    <dbReference type="InParanoid" id="A0A5N4ASL2"/>
    <dbReference type="OrthoDB" id="2423701at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000020">
        <property type="entry name" value="Stress-induced phosphoprotein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904:SF532">
        <property type="entry name" value="HEAT SHOCK PROTEIN STI1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904">
        <property type="entry name" value="TPR REPEAT CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="5">
        <location>
            <begin position="10"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="5">
        <location>
            <begin position="78"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="209"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="230"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0800334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="245" mass="27942" checksum="2CDCFDD208ED8ECE" modified="2020-02-26" version="1">MTENNEQESVESLKELGNTAIRNKKYEEAILHYTYALKMEPTNFTLYSNRSFAFLKVHQYYLAMEDANETIRLNPSWAKGYFRKGEIELATYQYSDAFNSYQKALMLQPNDSVIISAMTKTLQEQKKDQNADSQIPWVGAGVGIVLGVIIVIADYMCTNKPTLTHPILMALLTITIAMIGYGIARALRYYTKCQRNALVDVPINLFDEENMPADDTGKDETESKTTTNHRYSKSQARQRYKKGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AU28</accession>
    <name>A0A5N4AU28_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF5641 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_06459</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000004">
        <property type="protein sequence ID" value="KAB0800720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AU28"/>
    <dbReference type="InParanoid" id="A0A5N4AU28"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040676">
        <property type="entry name" value="DUF5641"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18701">
        <property type="entry name" value="DUF5641"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5641" evidence="1">
        <location>
            <begin position="617"/>
            <end position="711"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0800720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="714" mass="81313" checksum="D31E73B144342424" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AU58</accession>
    <name>A0A5N4AU58_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Ionotropic glutamate receptor C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PPYR_06507</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">1611_PpyrPB1</strain>
            <tissue evidence="19">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000004">
        <property type="protein sequence ID" value="KAB0800768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AU58"/>
    <dbReference type="FunCoup" id="A0A5N4AU58">
        <property type="interactions" value="10"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AU58"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13717">
        <property type="entry name" value="PBP2_iGluR_putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000080">
        <property type="entry name" value="Glutamate receptor ionotropic, kainate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000024">
        <property type="entry name" value="Glutamate receptor, ionotropic, delta 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001508">
        <property type="entry name" value="Iono_Glu_rcpt_met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015683">
        <property type="entry name" value="Ionotropic_Glu_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18966">
        <property type="entry name" value="IONOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00177">
        <property type="entry name" value="NMDARECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00918">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00079">
        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="525"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="597"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="821"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="17">
        <location>
            <begin position="401"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="18">
        <location>
            <begin position="411"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="486"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="736"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="site" description="Crucial to convey clamshell closure to channel opening" evidence="14">
        <location>
            <position position="630"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with the cone snail toxin Con-ikot-ikot" evidence="14">
        <location>
            <position position="657"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="51"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="748"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="19">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAB0800768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="21">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="903" mass="103693" checksum="74843396562DF513" modified="2020-02-26" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AVJ1</accession>
    <name>A0A5N4AVJ1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PPYR_05708</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000003">
        <property type="protein sequence ID" value="KAB0801354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AVJ1"/>
    <dbReference type="InParanoid" id="A0A5N4AVJ1"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000047">
        <property type="entry name" value="Trypsin eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050430">
        <property type="entry name" value="Peptidase_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276:SF98">
        <property type="entry name" value="FI18310P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276">
        <property type="entry name" value="POLYSERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 8" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S1" evidence="9">
        <location>
            <begin position="11"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0801354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="244" mass="26410" checksum="7F28A454AB659EAE" modified="2020-02-26" version="1">MPKGTFENGRVIGGSPAPDNAYPYHIAIWRRDWSLKWVYHCGGSIINERHVLTAAHCVSGGQDAANFRIVAGNHKLSDVQQAVYAVSEIIIHEDFERFALNDDIAILKLNEAITYGVRIQPVGLAEVYPPPGTNCTVTGWGLVGYPSYNTPDELQYIQLKTISLDECKARLAPVGVAVSDEQICTLTKAGEGVCKGDSGGPLVDNASGKQIGVVSWGPYTCASGYSDVYTNVYAYRSWIGQHSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AVV1</accession>
    <name>A0A5N4AVV1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PPYR_05712</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000003">
        <property type="protein sequence ID" value="KAB0801358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A5N4AVV1">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AVV1"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051496">
        <property type="term" value="P:positive regulation of stress fiber assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.900.10:FF:000003">
        <property type="entry name" value="Rho guanine nucleotide exchange factor 10 like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039919">
        <property type="entry name" value="ARHGEF10/ARHGEF17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12877">
        <property type="entry name" value="RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12877:SF15">
        <property type="entry name" value="RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19057">
        <property type="entry name" value="PH_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19056">
        <property type="entry name" value="WD40_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="5">
        <location>
            <begin position="691"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="173"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="270"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="426"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="631"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1174"/>
            <end position="1241"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="981"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="204"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="299"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="643"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1174"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1201"/>
            <end position="1213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0801358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1545" mass="172604" checksum="F4612BDF6861F932" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AW12</accession>
    <name>A0A5N4AW12_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4806 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_05861</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000003">
        <property type="protein sequence ID" value="KAB0801507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AW12"/>
    <dbReference type="InParanoid" id="A0A5N4AW12"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032071">
        <property type="entry name" value="DUF4806"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16064">
        <property type="entry name" value="DUF4806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4806" evidence="1">
        <location>
            <begin position="263"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0801507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="371" mass="43040" checksum="5164961C2EED49F4" modified="2020-02-26" version="1">MAYINCRVFVYRALRYILFQRLHHFIMFKIVQTIEDNLKVLTAVPQSWEKNGILFWPPGPGKKAYTLRKDASNLPNLNTWTKTKCQIKRDNILTLKEALHQEKILAEFEDTEDEENYRLCKTINRLHPVMKTIAVDDFNHLMTEADPDPEPELMNNNTHNTPNMELTVINSVQDINNVQSLPGDKAEDKALELEVENPVLHSLAIEEKLKYLEKKQEELLKSVAGLHIKFDKLLDLMAANTASSNREPLIESADDTLNDLGLFPIDDTVKLNEVEQRLQDKDFQMLLIKKLSDIGGTDGKKNFNKIVYMVLDAIFERKFLMEISWTGSTKTKGKKKISMLQYKETLQMFFKVIKMADSRYLFLCAFFLFKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AW55</accession>
    <name>A0A5N4AW55_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tumor necrosis factor alpha-induced protein 8-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_03750</name>
        <name evidence="2" type="ORF">PPYR_04114</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0801564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0801928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AW55"/>
    <dbReference type="FunCoup" id="A0A5N4AW55">
        <property type="interactions" value="219"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AW55"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1440.160:FF:000001">
        <property type="entry name" value="Tumor necrosis factor alpha-induced protein 8-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.160">
        <property type="entry name" value="Tumor necrosis factor alpha-induced protein 8-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008477">
        <property type="entry name" value="TNFAIP8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038355">
        <property type="entry name" value="TNFAIP8_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12757:SF1">
        <property type="entry name" value="PROTEIN SALIVARY GLANDS MARRED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12757">
        <property type="entry name" value="TUMOR NECROSIS FACTOR INDUCED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05527">
        <property type="entry name" value="TNFAIP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0801564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0801928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="188" mass="21524" checksum="8B639E8D631BE0D0" modified="2020-02-26" version="1">MSDTGFRARDIGLRAQKKILSRMAGKHVARALIDDVTASLLDNLYCLAKQYSHNKKEAEKLIKNIIKIVIKLGVLHRNGVFSQEELNYSEHVKNKLHMAVMAVISFHEVDFSYDRNYLISALNESHKCLQFIVSKHLTEKSLARIDSVFHFFTNDHFLDAIFKTNSEYKDVVSRIVSDLNKAIDNGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AWZ4</accession>
    <name>A0A5N4AWZ4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ZSWIM1/3 RNaseH-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_04047</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0801861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AWZ4"/>
    <dbReference type="InParanoid" id="A0A5N4AWZ4"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052579">
        <property type="entry name" value="Zinc_finger_SWIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048324">
        <property type="entry name" value="ZSWIM1-3_RNaseH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31569">
        <property type="entry name" value="SWIM-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31569:SF4">
        <property type="entry name" value="SWIM-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21056">
        <property type="entry name" value="ZSWIM1-3_RNaseH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ZSWIM1/3 RNaseH-like" evidence="1">
        <location>
            <begin position="141"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0801861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="284" mass="33040" checksum="C8DECB6292F01B0C" modified="2020-02-26" version="1">MSHIFKIGKTFHSYSEVESQKFRPSGSWQRDTQTFKKEQLCPAHVSLRVTTDGRDLEVRSVSESHSHDRSMVQLQYLPHQRRLRSKDKENVEELLALRANRKLVKQKLERNTRKILTLKDLSNIEKSGKKSENLDECVDVLRNQYNAEVNILKDGENNFKGMFIQTFNMKNTLKAYPEFLGIDGTYKLINLGIPVFLIALEDRNCQIEIVSLCVLTTMDKESFTWFLKTFRPQTELTKSIMTDKDLLERSVIKDIVPEANVIICIFYSMRSFSQEITCEKMGIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AXK0</accession>
    <name>A0A5N4AXK0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Polyadenylate-binding protein</fullName>
            <shortName evidence="9">PABP</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PPYR_04199</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Binds the poly(A) tail of mRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the polyadenylate-binding protein type-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AXK0"/>
    <dbReference type="InParanoid" id="A0A5N4AXK0"/>
    <dbReference type="OrthoDB" id="19742at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12378">
        <property type="entry name" value="RRM1_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12379">
        <property type="entry name" value="RRM2_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12380">
        <property type="entry name" value="RRM3_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12381">
        <property type="entry name" value="RRM4_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000651">
        <property type="entry name" value="Poly(A) binding protein cytoplasmic 1 like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000003">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000021">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000091">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1900.10">
        <property type="entry name" value="c-terminal domain of poly(a) binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036053">
        <property type="entry name" value="PABP-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006515">
        <property type="entry name" value="PABP_1234"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002004">
        <property type="entry name" value="PABP_HYD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034364">
        <property type="entry name" value="PABP_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045305">
        <property type="entry name" value="RRM2_I_PABPs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01628">
        <property type="entry name" value="PABP-1234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24012">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00658">
        <property type="entry name" value="MLLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00517">
        <property type="entry name" value="PolyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63570">
        <property type="entry name" value="PABC (PABP) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51309">
        <property type="entry name" value="PABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 8 9" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="11"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="99"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="192"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="295"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="PABC" evidence="12">
        <location>
            <begin position="504"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="472"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAB0802013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="586" mass="65782" checksum="A5682EF309E7AAD8" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AYT0</accession>
    <name>A0A5N4AYT0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Coronin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_04594</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the WD repeat coronin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AYT0"/>
    <dbReference type="InParanoid" id="A0A5N4AYT0"/>
    <dbReference type="OrthoDB" id="1850764at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000502">
        <property type="entry name" value="Coronin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015505">
        <property type="entry name" value="Coronin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015048">
        <property type="entry name" value="DUF1899"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10856">
        <property type="entry name" value="CORONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10856:SF44">
        <property type="entry name" value="CORONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08953">
        <property type="entry name" value="DUF1899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16300">
        <property type="entry name" value="WD40_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01166">
        <property type="entry name" value="DUF1899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01167">
        <property type="entry name" value="DUF1900"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="DUF1899" evidence="8">
        <location>
            <begin position="41"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="114"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="164"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU280818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0802408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="570" mass="64591" checksum="0783AF07457683F2" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AZ23</accession>
    <name>A0A5N4AZ23_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PPYR_04694</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERG4/ERG24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AZ23"/>
    <dbReference type="FunCoup" id="A0A5N4AZ23">
        <property type="interactions" value="598"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AZ23"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005637">
        <property type="term" value="C:nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050613">
        <property type="term" value="F:Delta14-sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006695">
        <property type="term" value="P:cholesterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001171">
        <property type="entry name" value="ERG24_DHCR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257:SF55">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE LBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01222">
        <property type="entry name" value="ERG4_ERG24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50244">
        <property type="entry name" value="S5A_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="220"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="264"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="309"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="343"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="401"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="507"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="574"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="52"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAB0802508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="635" mass="72249" checksum="C2FBF1A9660CAE80" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B0E3</accession>
    <name>A0A5N4B0E3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Torsin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_05066</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ClpA/ClpB family. Torsin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B0E3"/>
    <dbReference type="InParanoid" id="A0A5N4B0E3"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071218">
        <property type="term" value="P:cellular response to misfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010448">
        <property type="entry name" value="Torsin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10760:SF2">
        <property type="entry name" value="LD13476P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10760">
        <property type="entry name" value="TORSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06309">
        <property type="entry name" value="Torsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0802880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="140" mass="15697" checksum="B8E57FE6B184E4E5" modified="2020-02-26" version="1">MRVYKLIIFLCFILHCTVIGLLDPFSLGSAAAVLGLGYLIYDQTYCKWKECCTEKEIPGNISQLAAVLKSKVYGQHLAEEIIIKALKPHWNEKYRPLKALTLSFHGWPGGGKTYITGFIKEALFTLGGASDHVHHFVSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B1F3</accession>
    <name>A0A5N4B1F3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">OPA3-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_00356</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OPA3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B1F3"/>
    <dbReference type="InParanoid" id="A0A5N4B1F3"/>
    <dbReference type="OrthoDB" id="2129069at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019216">
        <property type="term" value="P:regulation of lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010754">
        <property type="entry name" value="OPA3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12499:SF0">
        <property type="entry name" value="OPTIC ATROPHY 3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12499">
        <property type="entry name" value="OPTIC ATROPHY 3 PROTEIN OPA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07047">
        <property type="entry name" value="OPA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="117"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0803386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="148" mass="17147" checksum="C6A4A50D1C25E064" modified="2020-02-26" version="1">MSIVLLKLGTILAHQFTKPFAYYLTEKAKRSRLFRNYVCLPSARIFHWGEVKAKMWMLSLGTAVQIPIRNEKMATELGANLFAEIIVFGTISSIVINEYVRTRKKDAKKEARRKQIIVDLKQKLEELSTQVQHHQGQLEELLKLYQDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B3Q8</accession>
    <name>A0A5N4B3Q8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_01221</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B3Q8"/>
    <dbReference type="InParanoid" id="A0A5N4B3Q8"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0804251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="167" mass="19164" checksum="A49337A9FDDD89F4" modified="2020-02-26" version="1">MRLAMTLKYLAHGGSFVNLCFEFRVGHSTASKTIRETCEAIWEVLHTEYFKRSTDQDWLNISEEFWTRWNFPNTLGAIDGKHVAVQCPTNSGSLYYNYKKYYNIGAYGSENDAGIFKRSQIKIDMETVSSSLPEGELNGSSAKVPYYFVGRIPLDRLMDKAVKKIQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B4G7</accession>
    <name>A0A5N4B4G7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DDE-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_01414</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B4G7"/>
    <dbReference type="InParanoid" id="A0A5N4B4G7"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF74">
        <property type="entry name" value="POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
        <property type="entry name" value="HTH_psq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH psq-type" evidence="2">
        <location>
            <begin position="29"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="DDE-1" evidence="1">
        <location>
            <begin position="216"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0804444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="423" mass="48934" checksum="70C9498EE7DEB1AE" modified="2020-02-26" version="1">MIYEDHQLDMPRVYKKDPRGKVNKKIDSDALARALRDIKDGMSYRTAAYTYGIHYSVLFRHKHNPEIRKKGGQTQLSKTEENALIQVLEVCSEWGYPLDHYDLRKIVKQYLDSRGKRLLRFKDNMPGREFAFSFMKRHKDRLRDRVCQNIKRSRAAVSSVILNNYFNNLEKELEGVPPSHTVNFDETNLSDDPGRKKVISKRGCRYPERIMNTSKSATSIMFAAAGDGKLLPCYVVYKAQNLYDSWTVGGPKGTRYNRSNSGWFESASFEDWVEKIAIPYLKKLDGKKILIGDNLSSHFSPKTIRLCMEYNIHFVFLPPNSTHMTQPLDVAFFRPLKTAWRNVLLSWKKGEGQKKCSIPKDKFPHLLKNLLEEIHSSSESNIKSGFRKCGVCPINRQEVLSRLPEDVEEEDVTNMLMIQLSHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B4W7</accession>
    <name>A0A5N4B4W7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Down syndrome cell adhesion molecule-like protein Dscam2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PPYR_01631</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">1611_PpyrPB1</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Synapse</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A5N4B4W7">
        <property type="interactions" value="204"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4B4W7"/>
    <dbReference type="OrthoDB" id="5982258at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048812">
        <property type="term" value="P:neuron projection morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20956">
        <property type="entry name" value="IgI_4_Dscam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20958">
        <property type="entry name" value="IgI_5_Dscam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20954">
        <property type="entry name" value="IgI_7_Dscam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000333">
        <property type="entry name" value="Down syndrome cell adhesion molecule"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000017">
        <property type="entry name" value="Down syndrome cell adhesion molecule b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000104">
        <property type="entry name" value="Down syndrome cell adhesion molecule b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000093">
        <property type="entry name" value="Down syndrome cell adhesion molecule, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000308">
        <property type="entry name" value="Down syndrome cell adhesion molecule, isoform D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000310">
        <property type="entry name" value="Down syndrome cell adhesion molecule, isoform D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000324">
        <property type="entry name" value="Down syndrome cell adhesion molecule, isoform D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000678">
        <property type="entry name" value="Down syndrome cell adhesion molecule-like protein Dscam2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000719">
        <property type="entry name" value="nephrin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000028">
        <property type="entry name" value="Neuronal cell adhesion molecule"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000032">
        <property type="entry name" value="palladin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056754">
        <property type="entry name" value="DSCAM/DSCAML_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170:SF6">
        <property type="entry name" value="CONTACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170">
        <property type="entry name" value="PROTEIN SIDEKICK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25059">
        <property type="entry name" value="FN3_DSCAM-DSCAML_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 15" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0770">Synapse</keyword>
    <keyword evidence="2 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024315656" description="Down syndrome cell adhesion molecule-like protein Dscam2" evidence="15">
        <location>
            <begin position="21"/>
            <end position="1936"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1618"/>
            <end position="1638"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="16">
        <location>
            <begin position="28"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="16">
        <location>
            <begin position="142"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="16">
        <location>
            <begin position="236"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="16">
        <location>
            <begin position="330"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="16">
        <location>
            <begin position="423"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="16">
        <location>
            <begin position="521"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="16">
        <location>
            <begin position="612"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="16">
        <location>
            <begin position="710"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="16">
        <location>
            <begin position="807"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="17">
        <location>
            <begin position="909"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="17">
        <location>
            <begin position="1009"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="17">
        <location>
            <begin position="1117"/>
            <end position="1213"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="17">
        <location>
            <begin position="1217"/>
            <end position="1312"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="16">
        <location>
            <begin position="1314"/>
            <end position="1400"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="17">
        <location>
            <begin position="1404"/>
            <end position="1497"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="17">
        <location>
            <begin position="1498"/>
            <end position="1595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1647"/>
            <end position="1667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1745"/>
            <end position="1787"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1827"/>
            <end position="1936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1745"/>
            <end position="1761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1833"/>
            <end position="1848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="1852"/>
            <end position="1870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1871"/>
            <end position="1892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1903"/>
            <end position="1917"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAB0804661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="20">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1936" mass="214857" checksum="8D77CAE2A3FEC919" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B587</accession>
    <name>A0A5N4B587_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_01745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B587"/>
    <dbReference type="InParanoid" id="A0A5N4B587"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="499"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="685"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="763"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="373"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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            <end position="560"/>
        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="566"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="589"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="687"/>
            <end position="700"/>
        </location>
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        <location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <end position="811"/>
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        <location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <end position="866"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="891"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <end position="945"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="952"/>
            <end position="963"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0804775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1057" mass="120050" checksum="6421F646176F4217" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B612</accession>
    <name>A0A5N4B612_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_01964</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B612"/>
    <dbReference type="InParanoid" id="A0A5N4B612"/>
    <dbReference type="OrthoDB" id="542013at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0804994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="322" mass="35805" checksum="0329DB7C61A816D0" modified="2020-02-26" version="1">MWKYLTGTILTGSLLYVLKKYFAGGVCKCIERLDRQVVIVTGASSGIGEALAFLLAERGATIILACRDLTKANEVRAEILKEFSVPVFVKELDLNSFHSISKFANNINTEFNSVYALVNNAGVFYAPQQLTEDLFDVTFQTNYLGPFVLTHLLLKSLTASPDSRIVNVASEAHRAINIDQLMSITRSQTLSRSHISAYAASKLALVLFTKHLANKLANTKTLVNAVNPGNCETDIFRHFPFLSNKWLFALQWIIRIIVIKHPLEGAQSVLHAILTEDSSSGQYITDCKSDVPSIPCLNENVVVQYYDLTCKILKESGRDFCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B6X1</accession>
    <name>A0A5N4B6X1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_02286</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0805316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B6X1"/>
    <dbReference type="InParanoid" id="A0A5N4B6X1"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33332">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0805316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="111" mass="12688" checksum="6FDD59B60ACCFD5C" modified="2020-02-26" version="1">MLPLTNGVPQGSILGPLPFLLYINDLSHNIPDQCFCLLYADDTTLLVKDQDMHTLISNSECCFNSAVKWCNTSDLRINVSKTEKMILSLRRLDHDNPEYVRFLGVRLDLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B767</accession>
    <name>A0A5N4B767_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MADF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_02419</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0805449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B767"/>
    <dbReference type="InParanoid" id="A0A5N4B767"/>
    <dbReference type="OrthoDB" id="9909584at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21505">
        <property type="entry name" value="MADF DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21505:SF12">
        <property type="entry name" value="MADF DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00595">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51029">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MADF" evidence="2">
        <location>
            <begin position="10"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0805449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="262" mass="30026" checksum="64E9FEE7E0459B6A" modified="2020-02-26" version="1">MSWSNREVRVLIEEVQKYPCLYLVKSANYKNKHARNEALASIVKALLPLRPGVCENDIKAKFNGIKSNFFSEHRKVLASQKSGAGSDDVYKPTLWYYDLLVFLLEHYETRSAYDSLGEASQTQTQNETITESLEEEVMEEDTVYMLDTETGMLIPESNISEIDREQPPILNTPKTNCNSNRKRKKTSNEDNSQFFMESTKALQNLTAAMQSKQSDKLLGDKNQILANYIVSKLAKIHEEIKEEIEMKIVNILFEGIQRSNNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B7W2</accession>
    <name>A0A5N4B7W2_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_02667</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0805697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B7W2"/>
    <dbReference type="InParanoid" id="A0A5N4B7W2"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049012">
        <property type="entry name" value="Mutator_transp_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051703">
        <property type="entry name" value="NF-kappa-B_Signaling_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019080">
        <property type="entry name" value="YqaJ_viral_recombinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46609">
        <property type="entry name" value="EXONUCLEASE, PHAGE-TYPE/RECB, C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46609:SF8">
        <property type="entry name" value="YQAJ VIRAL RECOMBINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20700">
        <property type="entry name" value="Mutator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09588">
        <property type="entry name" value="YqaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mutator-like transposase" evidence="2">
        <location>
            <begin position="2"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="YqaJ viral recombinase" evidence="1">
        <location>
            <begin position="140"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0805697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="201" mass="21875" checksum="D545D2E88B22EAFA" modified="2020-02-26" version="1">MDVNDAAVLSCITTGVGESQLLEQHAALDLPSLTSYIYRKSHLKVSAAIRKSAWSSMKEAGKEEARLARDLGEVTEDGIPMITVIADGAWRNTSDPIEKKIESLKSDLINSPSHIFGEHKSQPLGYFCDKDKPDEDDKVQEVTGLDVQTCGLFLHKDYPYLTASPDGLVADNGLLEVKCPASAAKLSIVEAIQEKKLNSCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1JZ08</accession>
    <name>A0A1Y1JZ08_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Complement component 1 Q subcomponent-binding protein, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_14640</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MAM33 family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01096820">
        <property type="protein sequence ID" value="JAV54552.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01096819">
        <property type="protein sequence ID" value="JAV54554.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01096818">
        <property type="protein sequence ID" value="JAV54556.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01096817">
        <property type="protein sequence ID" value="JAV54558.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1JZ08"/>
    <dbReference type="FunCoup" id="A0A1Y1JZ08">
        <property type="interactions" value="1457"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1JZ08"/>
    <dbReference type="OrthoDB" id="278212at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.280.10:FF:000005">
        <property type="entry name" value="Glycoprotein gC1qBP, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.280.10">
        <property type="entry name" value="Mitochondrial glycoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003428">
        <property type="entry name" value="MAM33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036561">
        <property type="entry name" value="MAM33_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10826">
        <property type="entry name" value="COMPLEMENT COMPONENT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10826:SF1">
        <property type="entry name" value="COMPLEMENT COMPONENT 1 Q SUBCOMPONENT-BINDING PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02330">
        <property type="entry name" value="MAM33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54529">
        <property type="entry name" value="Mitochondrial glycoprotein MAM33-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="JAV54552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0792681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="265" mass="29392" checksum="CD0397A511C9621F" modified="2017-08-30" version="1">MNSILKTATRINLRSLLNSSKNASSISAKAQQSSRNLWCLAASSATTRRDLTKYNTSKFQTQLCSCGAHTKAEKDLVEFLTEEIVAERKAQKSKTIPTDIDGFKAKLDGAEVTLTKTINDETIKIHFNVNHTVDTDAEPEISSTADKPDIGELKSKPSFKIDMVRDDTTVSLVCSFINADQQEDGYNDIFGIDEVSIYNGDWNENVYSVSGEVIDSYLYDLLLNYLDEKGITNEFIEKLSGYSTAYEHSAYISLLEGLSKFASGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1K635</accession>
    <name>A0A1Y1K635_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycosyl transferase CAP10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PPYR_09581</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Protein O-glucosyltransferase. Catalyzes the reaction that attaches glucose through an O-glycosidic linkage to a conserved serine residue found in the consensus sequence C-X-S-X-[PA]-C in epidermal growth factor-like repeats. Regulates Notch signaling by glucosylating Notch in the ER, glucosylation is required for the correct folding and cleavage of Notch.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GEZM01097383">
        <property type="protein sequence ID" value="JAV54236.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01097382">
        <property type="protein sequence ID" value="JAV54237.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1K635"/>
    <dbReference type="InParanoid" id="A0A1Y1K635"/>
    <dbReference type="OrthoDB" id="541052at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046527">
        <property type="term" value="F:glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006598">
        <property type="entry name" value="CAP10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051091">
        <property type="entry name" value="O-Glucosyltr/Glycosyltrsf_90"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203:SF122">
        <property type="entry name" value="GLYCOSYL TRANSFERASE CAP10 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203">
        <property type="entry name" value="KDEL LYS-ASP-GLU-LEU CONTAINING - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05686">
        <property type="entry name" value="Glyco_transf_90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00672">
        <property type="entry name" value="CAP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011907255" description="Glycosyl transferase CAP10 domain-containing protein" evidence="3">
        <location>
            <begin position="19"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase CAP10" evidence="4">
        <location>
            <begin position="211"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00045690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="JAV54237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0798588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="480" mass="56483" checksum="CE941D7C8D6B4315" modified="2017-08-30" version="1">MFTHIFILFPILFISVVGEPDFKVWGPGLKPHTIVMPARYFFLQSFNESCNLKDLDVEIEGTSPENQRCRIWKNILYTHNCLFIIRYKLYNTCDNLRISIKYGDREQTYEIKTRVYPEDCNCPRKDVGHWLKDWNCGSVPKQILKDLAMFKTVNFDTLREKILEKYNQPGAISLCHYVVKSNNLYRRCYGKYVGFKMFMDSILLSLSRKFLLPDIEFFVNLGDWPLVKDAKDSFPIFSWSGSTDTFDIVMPTYDLTESTLENMGRVMLDMLSVQGNVDFQWEDRISKVFWRGRDSNRERLHLITLSREYPHLFNVSLTNFFFFRDEEDKYGPKTEHVSFFKFFEYKYQVCIDGTVAAYRLPYLLGGGSLLFKQESKYYEHFYNDLIPNTHFMTVKRDLSDLVEKVNWAVANDDKAKEIANAGRSFAIENLLPKNIFCYHAFLLNEFSKRLTSKITVLNDMELVENTSGDCHCDKTNKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1KF15</accession>
    <name>A0A1Y1KF15_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Exocyst complex component 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PPYR_09473</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Growth cone</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Perinuclear region</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the EXO84 family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01085213">
        <property type="protein sequence ID" value="JAV60113.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1KF15"/>
    <dbReference type="FunCoup" id="A0A1Y1KF15">
        <property type="interactions" value="1575"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1KF15"/>
    <dbReference type="OrthoDB" id="642193at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030426">
        <property type="term" value="C:growth cone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01226">
        <property type="entry name" value="PH_RalBD_exo84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1220">
        <property type="entry name" value="Exo84p, C-terminal helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1210">
        <property type="entry name" value="Exo84p, N-terminal helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033961">
        <property type="entry name" value="Exo84"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032403">
        <property type="entry name" value="Exo84_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042561">
        <property type="entry name" value="Exo84_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042560">
        <property type="entry name" value="Exo84_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21426">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21426:SF12">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16528">
        <property type="entry name" value="Exo84_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08700">
        <property type="entry name" value="VPS51_Exo84_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PH" evidence="9">
        <location>
            <begin position="148"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="JAV60113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0798480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="698" mass="79924" checksum="E2C184041057BF70" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1KH87</accession>
    <name>A0A1Y1KH87_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Translocon Sec61/SecY plug domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PPYR_11822</name>
        <name evidence="16" type="ORF">PPYR_11827</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
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        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
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                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
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                <person name="Sander Lower S.E."/>
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                <person name="Debat H.J."/>
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                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
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                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
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                <person name="Debat H.J."/>
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                <person name="Shigenobu S."/>
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                <person name="Lower S.E."/>
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                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
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                <person name="Debat H.J."/>
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                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
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                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
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                <person name="Sander Lower S.E."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="term" value="C:membrane"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902936">
        <property type="term" value="F:phosphatidylinositol bisphosphate binding"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="SEC14"/>
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        <property type="entry name" value="Alpha-tocopherol transfer"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
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        <property type="entry name" value="N-terminal domain of phosphatidylinositol transfer protein sec14p"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CRAL-TRIO_dom"/>
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        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
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        <property type="entry name" value="CRAL/TRIO_N_dom"/>
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        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174">
        <property type="entry name" value="ALPHA-TOCOPHEROL TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174:SF224">
        <property type="entry name" value="RETINOL-BINDING PROTEIN PINTA"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00180">
        <property type="entry name" value="CRETINALDHBP"/>
    </dbReference>
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        <location>
            <begin position="90"/>
            <end position="254"/>
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        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="JAV63251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0794538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0794814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="283" mass="33202" checksum="D6371BD218D2000E" modified="2017-08-30" version="1">MAIFVYSNEIVKHYAEKFLNETEENYNAIIEIRQWLDTLPHLNAKKDDKSILCFLRGCKFNLELTKKKMKNFYVMKGERTEWFVDRNPLLPEISELVRMGVFVPLRKFSDNKMVVIIRTATHDPKVHKQDDVFKAGKMVLDVAIQEYYENATVFGICAIFDMTNISLAHAKQLPPSMIKKAVFAWQNYYSRPKQLEFINAPTYINVILSVFKSFMSAKLQGRVRAHYSGLESLHKVVSKDILPVEYGGSESTMDELIQYWHQKVLQYSDWFKEDEKYRAQVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1KSH3</accession>
    <name>A0A1Y1KSH3_PHOPY</name>
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        <recommendedName>
            <fullName evidence="3">WAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_06558</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01075029">
        <property type="protein sequence ID" value="JAV64333.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000004">
        <property type="protein sequence ID" value="KAB0800819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1KSH3"/>
    <dbReference type="InParanoid" id="A0A1Y1KSH3"/>
    <dbReference type="OrthoDB" id="8187079at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030414">
        <property type="term" value="F:peptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008197">
        <property type="entry name" value="WAP_dom"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033750801" description="WAP domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="WAP" evidence="3">
        <location>
            <begin position="19"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="JAV64333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0800819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="116" mass="12121" checksum="6A78AE5E3ABA1FAE" modified="2017-08-30" version="1">MTKILITLAVLSTLLYVAQGVSPSESCPVSNQMTICTPICKDDTQCFGQKCCPNICNTKSCTSANQRGSQSKYSGSSSGGSYGSSSGGAGSYCGNVKCNSFQKCKMDPATKRDKCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1KYP4</accession>
    <name>A0A1Y1KYP4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">THIF-type NAD/FAD binding fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_08307</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ubiquitin-activating E1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01069671">
        <property type="protein sequence ID" value="JAV66523.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1KYP4"/>
    <dbReference type="FunCoup" id="A0A1Y1KYP4">
        <property type="interactions" value="2507"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1KYP4"/>
    <dbReference type="OrthoDB" id="412647at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031510">
        <property type="term" value="C:SUMO activating enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019948">
        <property type="term" value="F:SUMO activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000744">
        <property type="entry name" value="Smt3 activating enzyme 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF162">
        <property type="entry name" value="SUMO-ACTIVATING ENZYME SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="2">
        <location>
            <begin position="14"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="JAV66523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0797313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="334" mass="37306" checksum="4D46B8A8973B77B0" modified="2017-08-30" version="1">MSEKELSAAEAELYDRQIRLWGIESQSRLRAANVLLIGIRGLGSEIAKNILLSGINSLTILDEGVVTENELLQNFLLNRDSIGQKIAEAVLSKAQALNPLVKITTDTSPLSEKTSAFYKDFTIIVATGLTTKQLIEIDSICRDFNVQFICGDVFGMFGYSLSDFQMHEYYVDQIRLPNRKRAHDGKASTSSEVITEKIQAKLNYPSINDALLNADSSAKGRRKRGLQLYYLMKLLIQFRDKNGRNPSVSSKDDDLAQMKAIRNEYLQDYQIKEENFKADVLNLVFGEITPICSIVGGVVAQEVIKAVSHKEAPIHNIFLLNPYTFSGKEEMVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1L170</accession>
    <name>A0A1Y1L170_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PPYR_13833</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">1611_PpyrPB1</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">1611_PpyrPB1</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
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        <subcellularLocation>
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        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01067807">
        <property type="protein sequence ID" value="JAV67413.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:iron ion binding"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Cytochrome P450"/>
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        <property type="entry name" value="Cytochrome P450"/>
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        <property type="entry name" value="CYP9F3-RELATED"/>
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        <location>
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            <end position="521"/>
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        <location>
            <position position="465"/>
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        <ligand>
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
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        <source>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAB0794213.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
    <sequence length="521" mass="61014" checksum="A7CF1D5A7A6C416E" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
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            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
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            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
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                <person name="Al-Wathiqui N."/>
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                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
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        <subcellularLocation>
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        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="GO" id="GO:0000428">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="P:DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Rpb4-like"/>
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    <proteinExistence type="inferred from homology"/>
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        <location>
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        </location>
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        <source>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00072215"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00073914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="JAV66700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0797646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="139" mass="16135" checksum="1A10AFECCC5D55EF" modified="2017-08-30" version="1">MMATTNTDLTEEDAADLQFPKEFENAETLLISEVHMLLEHRKAQNESAEDEQEFSDVFMKTLTYTDRFRKFKNKETISAVRNLLMQKKLHKFELAALANLCPETTEEAKSLIPSLEGRFEDEDLQAVLDDIQTKRSLQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1L6G9</accession>
    <name>A0A1Y1L6G9_PHOPY</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="4" type="ORF">PPYR_04699</name>
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    <organism evidence="3">
        <name type="scientific">Photinus pyralis</name>
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            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01065624">
        <property type="protein sequence ID" value="JAV68401.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="7340501at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0060255">
        <property type="term" value="P:regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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    </dbReference>
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        <property type="entry name" value="Actin-related protein 5"/>
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    </dbReference>
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        <property type="entry name" value="Putative actin-related protein 5"/>
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    </dbReference>
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        <property type="entry name" value="Actin, Chain A, domain 4"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Actin"/>
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    </dbReference>
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        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Actin-like ATPase domain"/>
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    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="326"/>
        </location>
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    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="351"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="JAV68401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0802513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="659" mass="75563" checksum="05EB2CC9163B3033" modified="2017-08-30" version="1"> </sequence>
</entry>
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    <accession>A0A1Y1L7N2</accession>
    <name>A0A1Y1L7N2_PHOPY</name>
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        <recommendedName>
            <fullName evidence="5">Protein quiver</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">PPYR_00742</name>
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    <organism evidence="2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
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            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
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            <taxon>Photinus</taxon>
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    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
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                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01067028">
        <property type="protein sequence ID" value="JAV67586.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KAB0803772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="InParanoid" id="A0A1Y1L7N2"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036029821" description="Protein quiver" evidence="1">
        <location>
            <begin position="21"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="JAV67586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0803772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="114" mass="12783" checksum="DA2FF0C2E403C2C1" modified="2017-08-30" version="1">MHFKLVLASVGLLCVGVTSGFTKNTCFQCHGSSDMFPQHIDNCRKFINITETSSCSPPGYCIFRVSTRMEYKKEIFGVYRSCSSSNCDSLRKMKGVNTLHCSQCEGNYCNTDSY</sequence>
</entry>
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    <accession>A0A1Y1L876</accession>
    <name>A0A1Y1L876_PHOPY</name>
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        <recommendedName>
            <fullName evidence="4">Aspartate--tRNA ligase, cytoplasmic</fullName>
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        <alternativeName>
            <fullName evidence="11">Aspartyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PPYR_14275</name>
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    <organism evidence="15">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">1611_PpyrPB1</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">1611_PpyrPB1</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Asp) + L-aspartate + ATP = L-aspartyl-tRNA(Asp) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19649"/>
            <dbReference type="Rhea" id="RHEA-COMP:9660"/>
            <dbReference type="Rhea" id="RHEA-COMP:9678"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.12" evidence="3"/>
    <dbReference type="EMBL" id="GEZM01062263">
        <property type="protein sequence ID" value="JAV69909.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
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        <property type="protein sequence ID" value="KAB0792316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="FunCoup" id="A0A1Y1L876">
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    <dbReference type="InParanoid" id="A0A1Y1L876"/>
    <dbReference type="OrthoDB" id="372395at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04320">
        <property type="entry name" value="AspRS_cyto_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00776">
        <property type="entry name" value="AsxRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000013">
        <property type="entry name" value="Aspartate--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02075">
        <property type="entry name" value="Asp_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004523">
        <property type="entry name" value="Asp-tRNA_synthase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
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            <begin position="225"/>
            <end position="530"/>
        </location>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00033155"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="JAV69909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAB0792316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="530" mass="59000" checksum="3C8BA63FFB41D24D" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LBG9</accession>
    <name>A0A1Y1LBG9_PHOPY</name>
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        <recommendedName>
            <fullName evidence="10">BTB domain-containing protein</fullName>
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    </protein>
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        <name evidence="8" type="ORF">PPYR_09436</name>
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    <organism evidence="7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
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            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
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            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
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        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
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        <subcellularLocation>
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        </subcellularLocation>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:animal organ development"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="P:developmental process involved in reproduction"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="P:neuron development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="BTB_POZ_BAB-like"/>
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        <property type="entry name" value="Bmp-induced factor"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Classic Zinc Finger"/>
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    </dbReference>
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        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Dros_DevTransReg"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
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        <property type="entry name" value="BTB DOMAIN TRANSCRIPTION FACTOR"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR23110:SF94">
        <property type="entry name" value="ZINC FINGER PROTEIN CHINMO"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BTB" evidence="5">
        <location>
            <begin position="33"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="364"/>
            <end position="392"/>
        </location>
    </feature>
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        <location>
            <begin position="392"/>
            <end position="420"/>
        </location>
    </feature>
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            <begin position="130"/>
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        </location>
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        </location>
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        </location>
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        </location>
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        </location>
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        </location>
    </feature>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="JAV69690.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAB0798443.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="435" mass="47948" checksum="1B195C6572A35628" modified="2017-08-30" version="1">MDSQQQQFCLKWNSFGSNLATSFSNLFKSESLADVTLFCEGVTFKAHKLILAACSKHLADLFETAPLHQNLLVILDGTSANNMSALLEFMYKGEVHVSQDALSSFLKAAECLQVKGLSIEHEKLAVAQSHTNMDTLDSPTSRKQLRVLNDDGDGTNLQQQSSPSPSYSPAMSPYMHPHHFRQYEQRIAASNNTSFEPLTKRALRSPNELLQETVRASVLRDGSKAGRPGSPGPMSLAYRPSSSSSCLLSQQPEADGPPENRFNSETTATALICPESKTNEQCRDPGCPEDLRMKIEPLLQDDPLSSTGSANGKNGAAANGSLGPLSNYEIDRENSDLIPASLWNSVTGKLAKTGSVTTPDGKKLKCPFCERLYGYETNLRAHIRQRHQGIRVPCPFCSRTFTRNNTVRRHIAREHKTELSMKAFQQSQQAHNHNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LCI2</accession>
    <name>A0A1Y1LCI2_PHOPY</name>
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        <recommendedName>
            <fullName evidence="13">Phosphatidylserine decarboxylase proenzyme, mitochondrial</fullName>
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            <recommendedName>
                <fullName evidence="13">Phosphatidylserine decarboxylase beta chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="13">Phosphatidylserine decarboxylase alpha chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PPYR_04072</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">1611_PpyrPB1</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">1611_PpyrPB1</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine. May be involved in lipid droplet biogenesis at the endoplasmic reticulum membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H(+) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CO2</text>
            <dbReference type="Rhea" id="RHEA:20828"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="EC" id="4.1.1.65"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
        <text evidence="13">Binds 1 pyruvoyl group covalently per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="13">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.</text>
    </comment>
    <comment type="subcellular location">
        <molecule>Phosphatidylserine decarboxylase alpha chain</molecule>
        <subcellularLocation>
            <location evidence="13">Mitochondrion inner membrane</location>
            <topology evidence="13">Peripheral membrane protein</topology>
            <orientation evidence="13">Intermembrane side</orientation>
        </subcellularLocation>
        <text evidence="13">Anchored to the mitochondrial inner membrane through its interaction with the integral membrane beta chain.</text>
    </comment>
    <comment type="subcellular location">
        <molecule>Phosphatidylserine decarboxylase beta chain</molecule>
        <subcellularLocation>
            <location evidence="13">Mitochondrion inner membrane</location>
            <topology evidence="13">Single-pass membrane protein</topology>
            <orientation evidence="13">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="13">Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type I sub-subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.65" evidence="13"/>
    <dbReference type="EMBL" id="GEZM01061243">
        <property type="protein sequence ID" value="JAV70608.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0801886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1LCI2"/>
    <dbReference type="FunCoup" id="A0A1Y1LCI2">
        <property type="interactions" value="1561"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1LCI2"/>
    <dbReference type="OrthoDB" id="4330at2759"/>
    <dbReference type="UniPathway" id="UPA00558">
        <property type="reaction ID" value="UER00616"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004609">
        <property type="term" value="F:phosphatidylserine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016540">
        <property type="term" value="P:protein autoprocessing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03208">
        <property type="entry name" value="PS_decarb_PSD_B_type1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003817">
        <property type="entry name" value="PS_Dcarbxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033177">
        <property type="entry name" value="PSD-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033661">
        <property type="entry name" value="PSD_type1_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00163">
        <property type="entry name" value="PS_decarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067:SF6">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE PROENZYME, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02666">
        <property type="entry name" value="PS_Dcarbxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2 13" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6 13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 13 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8 13" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="10 13" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="11 13" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 13 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="13" id="KW-0865">Zymogen</keyword>
    <feature type="chain" id="PRO_5034575820" description="Phosphatidylserine decarboxylase beta chain" evidence="13">
        <location>
            <begin position="1"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034575819" description="Phosphatidylserine decarboxylase alpha chain" evidence="13">
        <location>
            <begin position="353"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="topological domain" description="Mitochondrial matrix" evidence="13">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="topological domain" description="Mitochondrial intermembrane" evidence="13">
        <location>
            <begin position="73"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="13">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="13">
        <location>
            <position position="247"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="13">
        <location>
            <position position="353"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity" evidence="13">
        <location>
            <position position="353"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage (non-hydrolytic); by autocatalysis" evidence="13">
        <location>
            <begin position="352"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="modified residue" description="Pyruvic acid (Ser); by autocatalysis" evidence="13">
        <location>
            <position position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="JAV70608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAB0801886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="405" mass="46177" checksum="0F07A4CCAC9C9371" modified="2017-08-30" version="1">MYIYNVSRISRHISKACSALFQQKWNLFPLLSNLNNVKLISTNRGKVREWTSWRSIITGFVPIGICLVAVMQWRAYRKISSAHSAKQWQISCYCALPLRITSRCWGWLADKEIPTWIRPYIYGLYTSTFGVNLNEAASEDFKSYSSIGDFFARPLKEGVRTVDHTTCLVSPCDGTVLHFGTVSSGNIEQVKGVTYSLENFLGENSWNSRNNVEEDSYQDLLLHKVSPNSKLYQCVIYLAPGDYHRFHSPTDWEPTYRRHFSGKLLSVNPGMARWLPGLFCLNERAIYAGKWMHGFFSMVAVGATNVGSIKIYCDKLLETNKPKYKSKNVMDKCLDSNLRFKKGDPFGEFRMGSTIVIIFEAPSSFQFKLIPGEKVKMGQGICCANKEKYVDRVQKTKTNAFIHAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LQ36</accession>
    <name>A0A1Y1LQ36_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PPYR_03289</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. BUD32 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="GEZM01051279">
        <property type="protein sequence ID" value="JAV75056.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01051277">
        <property type="protein sequence ID" value="JAV75061.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1LQ36"/>
    <dbReference type="FunCoup" id="A0A1Y1LQ36">
        <property type="interactions" value="838"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1LQ36"/>
    <dbReference type="OrthoDB" id="3399at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070525">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000201">
        <property type="entry name" value="TP53-regulating kinase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022495">
        <property type="entry name" value="Bud32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03724">
        <property type="entry name" value="arch_bud32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12209:SF0">
        <property type="entry name" value="EKC_KEOPS COMPLEX SUBUNIT TP53RK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12209">
        <property type="entry name" value="NON-SPECIFIC SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <location>
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            <end position="225"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="JAV75061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAB0791489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="225" mass="25559" checksum="9406C18ADA19F635" modified="2017-08-30" version="1">MKDFELIKQGAEARIYKGVYLGKPTLVKQRFEKKYRHPDLDSTLTKERIKAESRAIVRCKSAGIETPALYLINLKTRSLYLEYFEHSITAKDFIKEASDELIEKVANDIGAVLAKLHGNNIIHGDLTTSNILLVNKRGTDDYTDYSQVKLVLIDFGLAHIDSSPEDKGVDLYVLERAIISIHNNPDRIFGLILKAYQNEYTSGHIEVLNKLDEVRSRGRKRLVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1M0H5</accession>
    <name>A0A1Y1M0H5_PHOPY</name>
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        <recommendedName>
            <fullName evidence="10">General transcription factor IIH subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PPYR_07099</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.</text>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFB1 family.</text>
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        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KAB0799219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
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        <property type="project" value="InterPro"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
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        <property type="entry name" value="BSD_dom_sf"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03909">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BSD" evidence="12">
        <location>
            <begin position="102"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="BSD" evidence="12">
        <location>
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        <location>
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        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00070129"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50858"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="JAV78518.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAB0799219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="560" mass="63517" checksum="206A425DA208C60F" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1M578</accession>
    <name>A0A1Y1M578_PHOPY</name>
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        <recommendedName>
            <fullName evidence="15">Golgi apparatus protein 1</fullName>
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    </protein>
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        <name evidence="13" type="ORF">PPYR_09634</name>
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    <organism evidence="12">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
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        <lineage>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
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            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
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            <taxon>Elateroidea</taxon>
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        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
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                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
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        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017134">
        <property type="term" value="F:fibroblast growth factor binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Cys-rich_GLG1_repeat"/>
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        <property type="entry name" value="Cys-rich_GLG1_repeat_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039728">
        <property type="entry name" value="GLG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11884:SF1">
        <property type="entry name" value="GOLGI APPARATUS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11884">
        <property type="entry name" value="SELECTIN LIGAND RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00839">
        <property type="entry name" value="Cys_rich_FGFR"/>
        <property type="match status" value="13"/>
    </dbReference>
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        <property type="entry name" value="GLG1_C_RICH"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="20"/>
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            <begin position="21"/>
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            <begin position="1048"/>
            <end position="1068"/>
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            <begin position="187"/>
            <end position="247"/>
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            <begin position="313"/>
            <end position="372"/>
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            <begin position="375"/>
            <end position="437"/>
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            <begin position="756"/>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00622"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Coils"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="JAV80979.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAB0798641.1"/>
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        <source>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    <sequence length="1080" mass="124031" checksum="4E3332BE4FA40FA3" modified="2017-08-30" version="1"> </sequence>
</entry>
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        <name type="scientific">Photinus pyralis</name>
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            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
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            <taxon>Elateroidea</taxon>
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        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
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                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
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            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8">1611_PpyrPB1</strain>
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    </reference>
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        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Photinus pyralis genome working group"/>
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                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
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            <taxon>Neoptera</taxon>
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    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
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            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
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        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
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                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
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    <reference evidence="10" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
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            <topology evidence="1">Multi-pass membrane protein</topology>
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        <property type="term" value="F:lipid transporter activity"/>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <begin position="291"/>
            <end position="318"/>
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="324"/>
            <end position="347"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="359"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="384"/>
            <end position="406"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="427"/>
            <end position="448"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="935"/>
            <end position="952"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1091"/>
            <end position="1117"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1137"/>
            <end position="1163"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1175"/>
            <end position="1199"/>
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        <location>
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            <end position="1307"/>
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            <end position="1617"/>
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        <source>
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        </source>
    </evidence>
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        <source>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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        <source>
            <dbReference type="PROSITE" id="PS50893"/>
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        <source>
            <dbReference type="EMBL" id="JAV84079.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAB0791349.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
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</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1MEY5</accession>
    <name>A0A1Y1MEY5_PHOPY</name>
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        <recommendedName>
            <fullName evidence="8">Putative rRNA methyltransferase</fullName>
            <ecNumber evidence="8">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">2'-O-ribose RNA methyltransferase SPB1 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PPYR_11501</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
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        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Probable methyltransferase involved in the maturation of rRNA and in the biogenesis of ribosomal subunits.</text>
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    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a ribonucleotide in rRNA + S-adenosyl-L-methionine = a 2'-O-methylribonucleotide in rRNA + S-adenosyl-L-homocysteine + H(+)</text>
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            <dbReference type="Rhea" id="RHEA-COMP:12164"/>
            <dbReference type="Rhea" id="RHEA-COMP:12165"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90675"/>
            <dbReference type="ChEBI" id="CHEBI:90676"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
            <location evidence="1 8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 8" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6 8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribosomal RNA methyltransferase FtsJ" evidence="10">
        <location>
            <begin position="24"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3381" evidence="12">
        <location>
            <begin position="235"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal RNA methyltransferase SPB1-like C-terminal" evidence="11">
        <location>
            <begin position="580"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
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            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
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            <begin position="566"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="753"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="353"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="686"/>
            <end position="723"/>
        </location>
    </feature>
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        <location>
            <begin position="457"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="482"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="573"/>
            <end position="585"/>
        </location>
    </feature>
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        <location>
            <begin position="586"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="770"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="781"/>
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        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
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    <feature type="binding site" evidence="8">
        <location>
            <position position="92"/>
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        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="117"/>
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        <ligand>
            <name>S-adenosyl-L-methionine</name>
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        </ligand>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
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        <source>
            <dbReference type="HAMAP-Rule" id="MF_03163"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF01728"/>
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        <source>
            <dbReference type="Pfam" id="PF07780"/>
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        <source>
            <dbReference type="Pfam" id="PF11861"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="JAV84389.1"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAB0794662.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="804" mass="93354" checksum="3EAEE9290D1067CE" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1MMN7</accession>
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        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="11" type="ORF">PPYR_13278</name>
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    <organism evidence="10">
        <name type="scientific">Photinus pyralis</name>
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        <name type="synonym">Lampyris pyralis</name>
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        <lineage>
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                <person name="Stanger-Hall K.F."/>
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            <begin position="137"/>
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        <source>
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    </evidence>
    <sequence length="367" mass="43235" checksum="CB2E0522AE04CB80" modified="2017-08-30" version="1">MASRILFHYMNCEKKLLFSTAFSKAYYFKPICVCCASNTSSSRRSIYKTEEVKKFRFFVLQHYLDYLKSYNAILEKKFPGAMRVYRVFMDGMKEFFNDLKLYIKLVHNLNIAGKSLETFNVREVELYEQMPKDMRRIAPLLILSILPLTHYVLFPIAYYFPRHLLCRHFWNLQQKSEFSIILLRKRLVHNKPVFRHLQLQLPKLKENALHKKWSVVLGLVGSGLQPQPEQIVACKDLFVNGPYHLMYLSGNHVKHLLKMHELHMGWFRRTRLGDRAVILQAMDRAILREGGVEILSTDNLRHACLIRGLNPMNMKNEDMVNWLKGWIAVSSEIDKDSLSLLLHCPILLAYNEPTNWQLIYDTKQPKL</sequence>
</entry>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
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                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
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            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
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        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
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            <dbReference type="PubMed" id="30324905"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
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        </source>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="249" mass="28192" checksum="BF692A7ABD10EFB3" modified="2017-08-30" version="1">MEEVNCKWKRPSSAPYPSIYKKFEGRRPINGVIPKFWVQDIPEDQFDAAVEFMMGGFPYDEPLNKYSKLESDSESMNTLRMFLKEMLKDKLGLICYAENPDPKGKPIIAGVNVTHIKTKDDENIVEIKGNTLSRIFETMEVVTNIKNVFDTFNVNACLNAMGLYVSNEFRGQGIGLEILKAREDLCKAVGISVIVTVFTATPSQIIAERAGYKTLSQISYSDLKRLGPKHTFPGINEHTEALKYMYKII</sequence>
</entry>
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    <reference evidence="1" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
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                <person name="Al-Wathiqui N."/>
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            <dbReference type="DOI" id="10.1038/srep38556"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
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        <property type="molecule type" value="Genomic_DNA"/>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="267" mass="30856" checksum="A76D0024DA4AC29F" modified="2017-08-30" version="1">MDFYNSVKKFLGLPVQKAPESSIEKRNDAPCCTPHNEDYEKFGFNIFSNPVEMHQYFERQMNEIMKSFGMFSGDGPFSGNADDEFFGGFKDPSFKGPFSFGFSEFPNEKELQHHDEPQEGNLRDRFLKRGYQTPRRNPQENTDSDLDKEFKADDLDRMLVPKVPQQPQRNFFFGRSMSSRTIRNSDGTYETHKTVTDQDGNQEVTITRKQGDKEYTIVTKTDKNGVAEVTENFVNLDESQKDSFLKNDAPKPILDTDVDDSLFSKFF</sequence>
</entry>
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    <accession>A0A1Y1MT29</accession>
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            <fullName evidence="6">1-Cys peroxiredoxin</fullName>
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    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
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                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a hydroperoxide + [protein]-dithiol = [protein]-disulfide + an alcohol + H2O</text>
            <dbReference type="Rhea" id="RHEA:10008"/>
            <dbReference type="Rhea" id="RHEA-COMP:10593"/>
            <dbReference type="Rhea" id="RHEA-COMP:10594"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peroxiredoxin family. Prx6 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01025034">
        <property type="protein sequence ID" value="JAV87630.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000004">
        <property type="protein sequence ID" value="KAB0800662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1MT29"/>
    <dbReference type="FunCoup" id="A0A1Y1MT29">
        <property type="interactions" value="39"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1MT29"/>
    <dbReference type="OrthoDB" id="2996783at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03016">
        <property type="entry name" value="PRX_1cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1020.10:FF:000001">
        <property type="entry name" value="1-Cys peroxiredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000011">
        <property type="entry name" value="Peroxiredoxin PRX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1020.10">
        <property type="entry name" value="Antioxidant, Horf6, Chain A, domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019479">
        <property type="entry name" value="Peroxiredoxin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045020">
        <property type="entry name" value="PRX_1cys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43503:SF3">
        <property type="entry name" value="DI01187P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43503">
        <property type="entry name" value="MCG48959-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10417">
        <property type="entry name" value="1-cysPrx_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="3 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1 9" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="4 9" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="11">
        <location>
            <begin position="4"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity" evidence="10">
        <location>
            <position position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00026176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="JAV87630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAB0800662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="225" mass="25632" checksum="82AC2789A305B45E" modified="2017-08-30" version="1">MSTLHIGDVVPNFKASTTKGTIQFYDWQDKSWVLLFSHPADFTPVCTTELGRIAVHNPHFQKRNVKLLAHSCDVLKSHVDWVNDIKSYCLDIPGEFPYPIIADETRELAYMLNMVDKQHFDDKNRQLTVRALYVIDPNHVLRLSMHYPNNIGRNVDEMLRVIDALQLVDKIPQVATPANWVPGEKVMILPTVSDVEADTLFPGGVDRVSMPSGISYVRTTTHYKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1MTP8</accession>
    <name>A0A1Y1MTP8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Protein turtle</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PPYR_07391</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GEZM01024232">
        <property type="protein sequence ID" value="JAV87845.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1MTP8"/>
    <dbReference type="FunCoup" id="A0A1Y1MTP8">
        <property type="interactions" value="107"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1MTP8"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098632">
        <property type="term" value="F:cell-cell adhesion mediator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070593">
        <property type="term" value="P:dendrite self-avoidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045467">
        <property type="term" value="P:R7 cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000733">
        <property type="entry name" value="Turtle, isoform F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000830">
        <property type="entry name" value="Turtle, isoform F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001453">
        <property type="entry name" value="Turtle, isoform G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001149">
        <property type="entry name" value="Turtle, isoform H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10075">
        <property type="entry name" value="BASIGIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10075:SF92">
        <property type="entry name" value="PROTEIN TURTLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13895">
        <property type="entry name" value="Ig_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="757"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="824"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="20"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="158"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="249"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="352"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="440"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="12">
        <location>
            <begin position="534"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="12">
        <location>
            <begin position="661"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="884"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1081"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="884"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1089"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1099"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="1131"/>
            <end position="1148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="JAV87845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAB0799511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1252" mass="138334" checksum="6D942DFFB908656B" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1MTQ6</accession>
    <name>A0A1Y1MTQ6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein mL66</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_00577</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the bacterial ribosomal protein bS18 family. Mitochondrion-specific ribosomal protein mL66 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01021465">
        <property type="protein sequence ID" value="JAV88991.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1MTQ6"/>
    <dbReference type="FunCoup" id="A0A1Y1MTQ6">
        <property type="interactions" value="206"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1MTQ6"/>
    <dbReference type="OrthoDB" id="10054543at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.640.10:FF:000011">
        <property type="entry name" value="28S ribosomal protein S18a, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.640.10">
        <property type="entry name" value="Ribosomal protein S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001648">
        <property type="entry name" value="Ribosomal_bS18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036870">
        <property type="entry name" value="Ribosomal_bS18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13479">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13479:SF66">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01084">
        <property type="entry name" value="Ribosomal_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46911">
        <property type="entry name" value="Ribosomal protein S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00061060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00071652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="JAV88991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0803607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="154" mass="17622" checksum="824DDAEFDCDE5CF5" modified="2017-08-30" version="1">MNTLLKFNWQGLIKAAFPLRTLSLFPKLQLKEIQEVQEGKSLIIKGVNVPSGREPFLLETENELCPICSSGLEVKHTDVLIISQFVRSDGCMLPRRVTGLCRRQQKRMSILVAMAQKAGLMPNLTPATSKKDPKKRFGWKRYNKYFDESTIKIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1MW61</accession>
    <name>A0A1Y1MW61_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Geranylgeranyl pyrophosphate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PPYR_05289</name>
        <name evidence="5" type="ORF">PPYR_14974</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01020153">
        <property type="protein sequence ID" value="JAV89358.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01020152">
        <property type="protein sequence ID" value="JAV89361.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01001006">
        <property type="protein sequence ID" value="KAB0790616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000003">
        <property type="protein sequence ID" value="KAB0800935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1MW61"/>
    <dbReference type="FunCoup" id="A0A1Y1MW61">
        <property type="interactions" value="1728"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1MW61"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042811">
        <property type="term" value="P:pheromone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001:SF44">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="JAV89358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0790616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0800935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="312" mass="36171" checksum="80729F98DA62FA03" modified="2017-08-30" version="1">MSTRSSVNSIHSKQGDKSQDEKLLQPFTYITQTPGKNIRSKLARAFNYWLNISEDKLERIEEIIQMLHNASLLIDDIQDNSILRRGIPVAHSIYGIASTINAANYVIFIALEKVLELNHPEATKVYTEQLLNLHRGQGMELYWRDNFVCPSEEEYEQMTIRKTGGLFMLAIRLMQLFSENKEDFTRLTEILGLSFQILDDYQNLHSKTYFRHKSYCEDLTEGKFSFPIVHGIQSNPNDGQIIHILRQRTKDNEVKKYCVSLLEKFGSFEYTRQKLVKLREEAVLEVAKLGGNPVMDQVIENFFKVINDDNVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1NCK6</accession>
    <name>A0A1Y1NCK6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">5'-nucleotidase domain-containing protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PPYR_06276</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'(3')-deoxyribonucleotidase family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01009177">
        <property type="protein sequence ID" value="JAV94630.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000004">
        <property type="protein sequence ID" value="KAB0800536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1NCK6"/>
    <dbReference type="FunCoup" id="A0A1Y1NCK6">
        <property type="interactions" value="960"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1NCK6"/>
    <dbReference type="OrthoDB" id="409330at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008253">
        <property type="term" value="F:5'-nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008380">
        <property type="entry name" value="HAD-SF_hydro_IG_5-nucl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016695">
        <property type="entry name" value="Pur_nucleotidase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02244">
        <property type="entry name" value="HAD-IG-Ncltidse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12103">
        <property type="entry name" value="5'-NUCLEOTIDASE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12103:SF12">
        <property type="entry name" value="FI20020P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05761">
        <property type="entry name" value="5_nucleotid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017434">
        <property type="entry name" value="Purine_5'-nucleotidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="366"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR017434-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR017434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="JAV94630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0800536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="509" mass="60150" checksum="47402B7C8E93A6F3" modified="2017-08-30" version="1">MLLCKTISISTFKQNLNYLEKLRCCDLSIFLRKHSTNRLELAYQMIKDKCDSKKLPKDVDVKAVFACNELDLREVNVYGFDYDYTLACYKPSMDYLLYNLGRQTLIEKYKYPQPISQLQYKPGYAIRGLHYDIQKGVLLKLDSFLQIQFGSVYRGLTALSNDEVLQLYRNRIIPIAAVEYSRSDDTQGKMVQLADLFSVPEMGLLCDVTDYFERNHIDYHPEILFRDVKNSVRLSHPVMHSIVGQNVSEYIKHNADLRIFFQRLVEAGKKLFLVTNSPFKFVNKGMEMLVGRDWKEFFDVIIVQARKPKFFTDKSRPIRVYDDKIGSHVWDRVVKLEKGIIYYEGTVKQLQDMTNWRGHQVLYFGDHPYSDLADVTLEHGWRTGAIINELTHEIETLNRTDFKRNANWLQMLTGLIEEHQDCEDPDEQKVFAQWMQERDCLRNDIKIIFNRQFGSVFRTYHNPTYFSRRLFRFADIYTSNITNLLSYSVNHTFYPRRGVMPHEYISYFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1NH22</accession>
    <name>A0A1Y1NH22_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Isocitrate dehydrogenase [NADP]</fullName>
            <ecNumber evidence="10">1.1.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PPYR_11562</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">1611_PpyrPB1</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">1611_PpyrPB1</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>D-threo-isocitrate + NADP(+) = 2-oxoglutarate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19629"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="10 12">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="10 12">Binds 1 Mg(2+) or Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.42" evidence="10"/>
    <dbReference type="EMBL" id="GEZM01005396">
        <property type="protein sequence ID" value="JAV96190.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0794723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1NH22"/>
    <dbReference type="InParanoid" id="A0A1Y1NH22"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004450">
        <property type="term" value="F:isocitrate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006097">
        <property type="term" value="P:glyoxylate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006739">
        <property type="term" value="P:NADP+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000002">
        <property type="entry name" value="Isocitrate dehydrogenase [NADP]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004790">
        <property type="entry name" value="Isocitrate_DH_NADP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00127">
        <property type="entry name" value="nadp_idh_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006156">
        <property type="entry name" value="PRK08299.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11822:SF21">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NADP], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11822">
        <property type="entry name" value="NADP-SPECIFIC ISOCITRATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000108">
        <property type="entry name" value="IDH_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0329">Glyoxylate bypass</keyword>
    <keyword evidence="6 10 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 10 12" id="KW-0464">Manganese</keyword>
    <keyword evidence="5 10 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0521">NADP</keyword>
    <keyword evidence="8 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="13">
        <location>
            <begin position="8"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="site" description="Critical for catalysis" evidence="11">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <feature type="site" description="Critical for catalysis" evidence="11">
        <location>
            <position position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="JAV96190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAB0794723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="408" mass="46733" checksum="5FA5F9B14D0858EC" modified="2017-08-30" version="1">MEKIKVGPIVDILGDEMTRIIWEEIKEKLIFPYLDIDLHIYDLGLENRDKTNDQITIECAEALMRFNVGVKCATITPDDKKAKEFNLKRTWNSPNCTIRNILGGTVFREAIICKNIPRFVTCWSKPIVIGHHAHADQYNATDFIVPCPGKLELVYKPKDGKEERYMVHDYKAAGIAMGMFNTDASIINFAHSSFQYALERSYPLFLSTKNTILTQYDGRFKDIFQELYTREYKKQFRAKGIWYKHYLIDEMVAYAIQSEGGFVWACKNYDGDVQSDCVGQGYGSLGLMTSILVSADGKTVQAEAAHGTVTRHFPIYQKGGETSTNSVASIFAWTRGLQHRAKLDDNQKLLRFTQILETVCIETIESGFMTKDLAMCVRGKRNIQRSDYMETFEFINKVAENLKHKLYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2023-09-13" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1NH40</accession>
    <name>A0A1Y1NH40_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_06724</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01002474">
        <property type="protein sequence ID" value="JAV97234.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0798844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1NH40"/>
    <dbReference type="InParanoid" id="A0A1Y1NH40"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036029945" evidence="1">
        <location>
            <begin position="22"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="JAV97234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0798844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="133" mass="15640" checksum="6782A7056DA291BD" modified="2017-08-30" version="1">MRLAHVLIVTLVLISCKVILGNEYFQQADYQPGHNGHLGGYYDNGWNYGYQDPHSVRRNSGYRNEQYDRYGNQIYPDNRLWRPNGQGPQWGGAFPMPYQESPKRNELYYDNLGSRKHDRSLLENLNNYPVKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1NHT5</accession>
    <name>A0A1Y1NHT5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Acireductone dioxygenase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Acireductone dioxygenase (Fe(2+)-requiring)</fullName>
            <shortName evidence="12">ARD'</shortName>
            <shortName evidence="12">Fe-ARD</shortName>
            <ecNumber evidence="12">1.13.11.54</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Acireductone dioxygenase (Ni(2+)-requiring)</fullName>
            <shortName evidence="12">ARD</shortName>
            <shortName evidence="12">Ni-ARD</shortName>
            <ecNumber evidence="12">1.13.11.53</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PPYR_01347</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 3-(methylsulfanyl)propanoate + CO + formate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:14161"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:17245"/>
            <dbReference type="ChEBI" id="CHEBI:49016"/>
            <dbReference type="ChEBI" id="CHEBI:49252"/>
            <dbReference type="EC" id="1.13.11.53"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 4-methylsulfanyl-2-oxobutanoate + formate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:24504"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:16723"/>
            <dbReference type="ChEBI" id="CHEBI:49252"/>
            <dbReference type="EC" id="1.13.11.54"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <cofactor evidence="12">
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </cofactor>
        <text evidence="12">Binds either 1 Fe or Ni cation per monomer. Iron-binding promotes an acireductone dioxygenase reaction producing 2-keto-4-methylthiobutyrate, while nickel-binding promotes an acireductone dioxygenase reaction producing 3-(methylsulfanyl)propanoate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 5/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the acireductone dioxygenase (ARD) family.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.54" evidence="12"/>
    <dbReference type="EC" id="1.13.11.53" evidence="12"/>
    <dbReference type="EMBL" id="GEZM01001928">
        <property type="protein sequence ID" value="JAV97453.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1NHT5"/>
    <dbReference type="FunCoup" id="A0A1Y1NHT5">
        <property type="interactions" value="390"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1NHT5"/>
    <dbReference type="OrthoDB" id="1867259at2759"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00878"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010308">
        <property type="term" value="F:acireductone dioxygenase (Ni2+-requiring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010309">
        <property type="term" value="F:acireductone dioxygenase [iron(II)-requiring] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02232">
        <property type="entry name" value="cupin_ARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000031">
        <property type="entry name" value="1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03154">
        <property type="entry name" value="Salvage_MtnD_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004313">
        <property type="entry name" value="ARD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027496">
        <property type="entry name" value="ARD_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23418">
        <property type="entry name" value="ACIREDUCTONE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23418:SF0">
        <property type="entry name" value="ACIREDUCTONE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03079">
        <property type="entry name" value="ARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 12" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="9 12" id="KW-0408">Iron</keyword>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 12" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="4 12" id="KW-0533">Nickel</keyword>
    <keyword evidence="11 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="12">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="JAV97453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAB0804377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="183" mass="21759" checksum="1F33A92C28EA3C92" modified="2017-08-30" version="1">MVRAWYMSNDVEDQRLENHLTPQKMVSLDEVKRLTGVEYFGINLNTYQTDGVLDNIKKERGYTYEDELVCSKECLQNYEEKLKIFFAEHLHTDEEIRFVVEGSGYFDVRDKNDEWIRIEVKPGDLIILPSGIYHRFTLDTTNFIRAKRFFVGEPVWTAYNRPADHFECRKSYVEKLNVRQISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N3ZYE8</accession>
    <name>A0A5N3ZYE8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PNK FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_15599</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01001970">
        <property type="protein sequence ID" value="KAB0790081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N3ZYE8"/>
    <dbReference type="FunCoup" id="A0A5N3ZYE8">
        <property type="interactions" value="1124"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N3ZYE8"/>
    <dbReference type="OrthoDB" id="19045at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046404">
        <property type="term" value="F:ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046403">
        <property type="term" value="F:polynucleotide 3'-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01625">
        <property type="entry name" value="HAD_PNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000078">
        <property type="entry name" value="Bifunctional polynucleotide phosphatase/kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000737">
        <property type="entry name" value="Bifunctional polynucleotide phosphatase/kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041388">
        <property type="entry name" value="FHA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006549">
        <property type="entry name" value="HAD-SF_hydro_IIIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013954">
        <property type="entry name" value="PNK3P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006551">
        <property type="entry name" value="Polynucleotide_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01664">
        <property type="entry name" value="DNA-3'-Pase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01662">
        <property type="entry name" value="HAD-SF-IIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12083">
        <property type="entry name" value="BIFUNCTIONAL POLYNUCLEOTIDE PHOSPHATASE/KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12083:SF9">
        <property type="entry name" value="BIFUNCTIONAL POLYNUCLEOTIDE PHOSPHATASE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13671">
        <property type="entry name" value="AAA_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17913">
        <property type="entry name" value="FHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08645">
        <property type="entry name" value="PNK3P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNK FHA" evidence="6">
        <location>
            <begin position="8"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0790081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="521" mass="58548" checksum="BEF19FFACC38BF22" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N3ZYR6</accession>
    <name>A0A5N3ZYR6_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_15466</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01001688">
        <property type="protein sequence ID" value="KAB0790200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N3ZYR6"/>
    <dbReference type="InParanoid" id="A0A5N3ZYR6"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31912:SF36">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31912">
        <property type="entry name" value="IP13529P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0790200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="658" mass="76074" checksum="05AB41169FA00A40" modified="2020-02-26" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N3ZZL8</accession>
    <name>A0A5N3ZZL8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_15096</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01001191">
        <property type="protein sequence ID" value="KAB0790510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N3ZZL8"/>
    <dbReference type="InParanoid" id="A0A5N3ZZL8"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000026">
        <property type="entry name" value="Transposon Ty3-G Gag-Pol polyprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF7">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="106"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0790510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="398" mass="45469" checksum="7F943965B4CC9BB0" modified="2020-02-26" version="1" fragment="single">MKLKCKCKKVEVLADFVITKGNVNPILGLKTCVELNLINRVEMVVLNDKDKFISDNHDLFQGLGKFYEKCSIELRDDVKPVVNPPRRVPLSVKDKLKDKLKELECKGIISKVEKPTGWVSNLIIVEKPDKSIRLCLDPKYLNLAMKRIPNVLIPTVQEIMTNLCNKKVFTVLDLKDGFWQIELTKDSSDLCTFSTPFGSYKFHRIPFGIKIAPEYFQYLNEKNFDDIRGVTVYFDDLLISADTEKEHDEILKKVIERARQMGVKFNKNKLQFKQESVRYLGHIFSSEGVKVDPERVKAIEGLKAPESKKELQSLLGMLNFLRPFISNLSELTSSLRGLLKDNVVFEWLPCHDDALVNIKKVLANSPTLVSFDTNKEITIQADASQHGLGCCLMQEFKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N3ZZW2</accession>
    <name>A0A5N3ZZW2_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_14983</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01001012">
        <property type="protein sequence ID" value="KAB0790611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N3ZZW2"/>
    <dbReference type="InParanoid" id="A0A5N3ZZW2"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031934">
        <property type="entry name" value="DUF4769"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31025">
        <property type="entry name" value="SI:CH211-196P9.1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31025:SF9">
        <property type="entry name" value="SI:DKEY-286J15.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15992">
        <property type="entry name" value="DUF4769"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0790611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="586" mass="67893" checksum="AC0A6A09849F1A1E" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A084</accession>
    <name>A0A5N4A084_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Brix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_15767</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000825">
        <property type="protein sequence ID" value="KAB0790723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A084"/>
    <dbReference type="FunCoup" id="A0A5N4A084">
        <property type="interactions" value="1091"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A084"/>
    <dbReference type="OrthoDB" id="10261452at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045112">
        <property type="entry name" value="PPAN-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12661">
        <property type="entry name" value="PETER PAN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12661:SF5">
        <property type="entry name" value="SUPPRESSOR OF SWI4 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="2">
        <location>
            <begin position="27"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0790723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="462" mass="53491" checksum="D3339B59E4681055" modified="2020-02-26" version="1">MVKKKKGRSVKRNPNVNSEPEELTQAPHSFIIQRGLTQGHIIELTRDFRKLMEPFTAKSLQEHKKNTIKDFVSVAGLLHVTHLCIFSQTEVGMYFKVGRLPRGPTLTFKVQNFSLAKDVVSSLKKQLVVEKAFKHSPLIILNSFSSEKAHMKLMASMFQNMFPKINLTNVDLNKIRRCVLLNYDPSTDLIDFRHYIIKIVPVGVSKGVKKVIQGKIPDLSKCDDISEFFTRAGTLSESEMEDDPNSHITVNQKLVSRGNVEQGQSAIKLTELGPRMTLQLMKVEDGLLDGIVLYHHLIHKTEEEKLEIQRKRDSKRKLKEKRKKIQEANKKRKEIEKEELKQKSLKGMHANVPKTTEKNSLEENDDDVQYYRDEVGEEPDKDLFLDNQPKSDISKVLKKFKKKKTSLEKNKQVTKYEDKFEKTKEKLGLKGRTQFKRNKFQVHNRVVGKTFNKRLNVKRKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2024-01-24" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A0A0</accession>
    <name>A0A5N4A0A0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Genetic suppressor element-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_15673</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000812">
        <property type="protein sequence ID" value="KAB0790743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A0A0"/>
    <dbReference type="InParanoid" id="A0A5N4A0A0"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022207">
        <property type="entry name" value="GSE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12540">
        <property type="entry name" value="DUF3736"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Genetic suppressor element-like" evidence="1">
        <location>
            <begin position="254"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0790743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="358" mass="39891" checksum="B730F1D4D5B95A79" modified="2020-02-26" version="1">MTSNSSTSTLTTCRNLDRSGEIKHAQTPVNCSIQQSHSPQLPISSPSYPVQTFLSSDFDCSKITIVESDKLFNGVSHSKQPPVLQPATNTNLEIGTNECKSAVSFWDLHLPYSTASTFNVQVQERESMGNITIKDLLSQSANNKALVDDENNTQPTLMGNESSCVVLNVPAVNCHQPPLKKQKVSKIDIATKRRKQLRERRHLKMNCIKSKSVSESDTAKIKRERIVFERITTHKGTVTNFGVPVFGFSDSSSSSSCCSSDYESDVADVEAVNVNDAPLVLDFAKEKVQFLKLFGIVTHRKRNGKYICFFKYTFHTAQMGCWFTRCCTNGPFEKLTVAVPPHFSLNNFLLFLIYGVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A0X8</accession>
    <name>A0A5N4A0X8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PPYR_02787</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">1611_PpyrPB1</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Late endosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Lysosome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the amino acid/polyamine transporter 2 family. SLC38A9 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0790987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A0X8"/>
    <dbReference type="InParanoid" id="A0A5N4A0X8"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF244">
        <property type="entry name" value="NEUTRAL AMINO ACID TRANSPORTER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0458">Lysosome</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0915">Sodium</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="244"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="331"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="358"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="390"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="16">
        <location>
            <begin position="1"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAB0790987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="417" mass="47412" checksum="8FB2F92E509C9DD9" modified="2020-02-26" version="1">MGTSLLAMPWGMERAGLFPGILVNIVVAALCLYTCYLILRINEDHGVNGHQNEVSDLARILLGKWAEFIARIFSLIVLIGSNIVYWVLMSNFLYHSVRVLYGYLLSINGLPTNSTVICPKNSSNVTVVDPLDSKAEGFDRIWDIYSTTPVILAVLMFPLLNFKSPTFFTKFNSLGTLSVMYLLIFVAVKSSTWGINMDSWVIEFNIKSTFCALSGMLSLSYFIHNIIISIMRSNRNPKNNNRDLSIAFLLVTFTYMFIGVVFYICFPLAKDCIEDNILNNFEKFDTMTIVARLLLLFQLFTVFPLISFMLRTDVFKNINLYTNNLAYEFSYRKVVAVNIVIVTICILFACFLPKIGTLIRYTGALSGLVYIFFLPSLMKIASLMKKEKLTFVKLTVYVLIVIFGFLNLISQFFIIDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A1C9</accession>
    <name>A0A5N4A1C9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Condensin complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PPYR_02930</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">1611_PpyrPB1</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the CND1 (condensin subunit 1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A5N4A1C9">
        <property type="interactions" value="860"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A1C9"/>
    <dbReference type="OrthoDB" id="436262at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000779">
        <property type="term" value="C:condensed chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010032">
        <property type="term" value="P:meiotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026971">
        <property type="entry name" value="CND1/NCAPD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032682">
        <property type="entry name" value="Cnd1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007673">
        <property type="entry name" value="Condensin_cplx_su1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024324">
        <property type="entry name" value="Condensin_cplx_su1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14222">
        <property type="entry name" value="CONDENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14222:SF2">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12717">
        <property type="entry name" value="Cnd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12922">
        <property type="entry name" value="Cnd1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017127">
        <property type="entry name" value="Condensin_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 10" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="6 10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Condensin complex subunit 1 N-terminal" evidence="14">
        <location>
            <begin position="77"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Condensin complex subunit 1 C-terminal" evidence="13">
        <location>
            <begin position="1051"/>
            <end position="1211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="935"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1273"/>
            <end position="1351"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="72"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="940"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="1297"/>
            <end position="1314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR017127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF12717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF12922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAB0791130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1351" mass="155395" checksum="50A069FD4E992ACF" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-09-13" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A1J4</accession>
    <name>A0A5N4A1J4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tudor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_02938</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A1J4"/>
    <dbReference type="InParanoid" id="A0A5N4A1J4"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0791138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="265" mass="30882" checksum="CF32A058B4E2D6E0" modified="2020-02-26" version="1">MQPFQKKGALVWCKDGDSWWSALLISQDGRSKALKVFIFGTHTISHVPENDVQDFVEHFDEHVAEGRSRGCVFKEGVVEALVELHLGQKNFTLDDVINLKLNDFPARAYRIPKWVQVYLNDKKMKKVSKGQYLNGRSLKRAMSDFEQREFNKGSLVWGKFGKSWWAAVVLTRNSYTNKDDKYKVMWLNDFTTSVIESDEVLDFVDNFQTITDQYMKRMSETWRRGTINALGVSSRLWIRKFTHEYLPRNSTIRNGNLPTKILNDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A359</accession>
    <name>A0A5N4A359_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Odorant receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PPYR_03574</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cell membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A359"/>
    <dbReference type="FunCoup" id="A0A5N4A359">
        <property type="interactions" value="7"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A359"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="170"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU351113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0791774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="371" mass="41247" checksum="13390898BF3EA492" modified="2020-02-26" version="1">MADEKLLSLAFRILGIVGLSPFKQNTFAKIRAGVGGAMCFCLCVLTLIEFPRQTDGVRAFRYMVEPTVGSYQSIIKALSLVVAQKRLLSLAAKVGKFKNVTQADHKLRSEGIHKRIGKLIRLYIMSFCTTGAGAFILALWAQDRVLPCPVYYFESWRGSPEYEIAVFLELLWYCCVILTIAGWDIMFYSFATYIYCELEAVKHEFRNMKAEDLENGLEATVRHHQMVLSCIPDLNSLCSVVFLNQCLSLAVAICAPMFMLAAETWSISLLLQELSMLVAVSGQLFCACLAGSLLTDQSESLATEVFHASSFWLGAPIGVQKQIVVIMQRSQKRDSLSLGGFGELNLHVFTQIMKLSLSFLNVILALKTGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A3I9</accession>
    <name>A0A5N4A3I9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">LRRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_03695</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A3I9"/>
    <dbReference type="InParanoid" id="A0A5N4A3I9"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000770">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050328">
        <property type="entry name" value="Dev_Immune_Receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373:SF262">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373">
        <property type="entry name" value="SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0791895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="623" mass="69829" checksum="3A48093A85928BF3" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A3N7</accession>
    <name>A0A5N4A3N7_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_03679</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A3N7"/>
    <dbReference type="InParanoid" id="A0A5N4A3N7"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0791879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="65" mass="7814" checksum="BE345C7FC1D3EC0F" modified="2020-02-26" version="1">MQIQKTSLNNFVQTCVYLYKRDRFLPPHYSAYITRAKLVLYTFYVWSLLLLYTVYVRAEKVAANQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A3V0</accession>
    <name>A0A5N4A3V0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein quiver</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_13929</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0791968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A3V0"/>
    <dbReference type="InParanoid" id="A0A5N4A3V0"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024392131" description="Protein quiver" evidence="1">
        <location>
            <begin position="22"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0791968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="117" mass="12782" checksum="B35D15B9111B6BCF" modified="2020-02-26" version="1">MASKVLIALLVVVTVAASAQALECMLCYPSDAGCTSGQVTTYETCRDLSVIGFKSLCYGARIEGTKDSRGCSHVRPSESFCRIIISREVAVRECRTCETDRCNYPPITGNMSSWTWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A472</accession>
    <name>A0A5N4A472_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mutator-like transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PPYR_14081</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A472"/>
    <dbReference type="InParanoid" id="A0A5N4A472"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049012">
        <property type="entry name" value="Mutator_transp_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051703">
        <property type="entry name" value="NF-kappa-B_Signaling_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034720">
        <property type="entry name" value="Viral_alk_exo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46609">
        <property type="entry name" value="EXONUCLEASE, PHAGE-TYPE/RECB, C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46609:SF8">
        <property type="entry name" value="YQAJ VIRAL RECOMBINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20700">
        <property type="entry name" value="Mutator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01771">
        <property type="entry name" value="Viral_alk_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mutator-like transposase" evidence="5">
        <location>
            <begin position="165"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF20700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0792120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="708" mass="80555" checksum="5EB2A21D3D309382" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A514</accession>
    <name>A0A5N4A514_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_14374</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A514"/>
    <dbReference type="InParanoid" id="A0A5N4A514"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="354"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="542"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="592"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="550"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="593"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="615"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0792415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="657" mass="73873" checksum="33E3C6863F67884A" modified="2020-02-26" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A582</accession>
    <name>A0A5N4A582_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Pickpocket protein 28</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PPYR_14378</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A582"/>
    <dbReference type="InParanoid" id="A0A5N4A582"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015280">
        <property type="term" value="F:ligand-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.470.10">
        <property type="entry name" value="Acid-sensing ion channels like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.770">
        <property type="entry name" value="YojJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF288">
        <property type="entry name" value="AMILORIDE-SENSITIVE NA+ CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01078">
        <property type="entry name" value="AMINACHANNEL"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="4 12" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="10 12" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="510"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAB0792419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="557" mass="65168" checksum="1432E459BF2B7C5B" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A7E6</accession>
    <name>A0A5N4A7E6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chitin-binding type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_12874</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A7E6"/>
    <dbReference type="InParanoid" id="A0A5N4A7E6"/>
    <dbReference type="OrthoDB" id="6780693at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024364484" description="Chitin-binding type-2 domain-containing protein" evidence="1">
        <location>
            <begin position="27"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0793254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="228" mass="24885" checksum="1340ED875F1269EB" modified="2020-02-26" version="1">MKQPSFITVLKLTVLHCIITVNVVNSYADYRQAPQRDDNEICKSTTLPLGLTCKSCSEIGRCVCESPGTNCKIHPIGTCSTGTFCDKGKCVTGTVCIPTEVPPFGCSSTGIFPDPYDCESYHFCLPPKTVGEPLEHRAAKCNKDGEQSYGYNPITTFCSTKLVNNKCSAMPIPFCKKELDKGIVGNNPGLHYMCLKAVIDGKLTETLYPYQFACQFGTKFNVAAGECR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A7K6</accession>
    <name>A0A5N4A7K6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PPYR_12912</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A7K6"/>
    <dbReference type="InParanoid" id="A0A5N4A7K6"/>
    <dbReference type="OrthoDB" id="3437960at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000634">
        <property type="entry name" value="Zinc finger X-chromosomal protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24399:SF70">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24399">
        <property type="entry name" value="ZINC FINGER AND BTB DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="260"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="292"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="370"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="398"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="426"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="454"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="482"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="510"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="536"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="566"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0793292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="650" mass="74080" checksum="8E846F56345CEE51" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A935</accession>
    <name>A0A5N4A935_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_13455</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A935"/>
    <dbReference type="InParanoid" id="A0A5N4A935"/>
    <dbReference type="OrthoDB" id="6784809at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024465117" evidence="2">
        <location>
            <begin position="21"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="186"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0793835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="700" mass="78675" checksum="E2459B7E81A0EF19" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AA03</accession>
    <name>A0A5N4AA03_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Integrin beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">PPYR_13775</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">1611_PpyrPB1</strain>
            <tissue evidence="21">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Cell membrane</location>
            <topology evidence="1 15">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the integrin beta chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0794155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AA03"/>
    <dbReference type="InParanoid" id="A0A5N4AA03"/>
    <dbReference type="OrthoDB" id="410592at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008305">
        <property type="term" value="C:integrin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005178">
        <property type="term" value="F:integrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033627">
        <property type="term" value="P:cell adhesion mediated by integrin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007157">
        <property type="term" value="P:heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000036">
        <property type="entry name" value="Integrin beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000002">
        <property type="entry name" value="Integrin beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.100">
        <property type="entry name" value="Cytochrome c1, transmembrane anchor, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1680.10">
        <property type="entry name" value="ligand-binding face of the semaphorins, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1510">
        <property type="entry name" value="ntegrin, alpha v. Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013111">
        <property type="entry name" value="EGF_extracell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015812">
        <property type="entry name" value="Integrin_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014836">
        <property type="entry name" value="Integrin_bsu_cyt_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002369">
        <property type="entry name" value="Integrin_bsu_VWA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032695">
        <property type="entry name" value="Integrin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057243">
        <property type="entry name" value="Integrin_I-EGF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10082">
        <property type="entry name" value="INTEGRIN BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10082:SF60">
        <property type="entry name" value="INTEGRIN BETA-PS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07974">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08725">
        <property type="entry name" value="Integrin_b_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00362">
        <property type="entry name" value="Integrin_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002512">
        <property type="entry name" value="Integrin_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01186">
        <property type="entry name" value="INTEGRINB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00187">
        <property type="entry name" value="INB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01241">
        <property type="entry name" value="Integrin_b_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69179">
        <property type="entry name" value="Integrin domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103575">
        <property type="entry name" value="Plexin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00243">
        <property type="entry name" value="I_EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12 14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 15" id="KW-0401">Integrin</keyword>
    <keyword evidence="11 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 17" id="KW-0732">Signal</keyword>
    <keyword evidence="5 15 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024467098" description="Integrin beta" evidence="17">
        <location>
            <begin position="19"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="704"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="domain" description="Integrin beta subunit VWA" evidence="19">
        <location>
            <begin position="32"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="18">
        <location>
            <begin position="457"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="18">
        <location>
            <begin position="499"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="18">
        <location>
            <begin position="538"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="18">
        <location>
            <begin position="580"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="domain" description="Integrin beta subunit cytoplasmic" evidence="20">
        <location>
            <begin position="727"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="36"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="197"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="252"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="394"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="474"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="479"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="518"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="520"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="525"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="556"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="563"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="574"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="596"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="598"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="603"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="615"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="628"/>
            <end position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR002512-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM01241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAB0794155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="776" mass="87583" checksum="C7624A76425DD56B" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AA36</accession>
    <name>A0A5N4AA36_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Meiotic nuclear division protein 1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_13803</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0794183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AA36"/>
    <dbReference type="InParanoid" id="A0A5N4AA36"/>
    <dbReference type="OrthoDB" id="273345at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040661">
        <property type="entry name" value="LZ3wCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040453">
        <property type="entry name" value="Mnd1_HTH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31398">
        <property type="entry name" value="MEIOTIC NUCLEAR DIVISION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31398:SF0">
        <property type="entry name" value="MEIOTIC NUCLEAR DIVISION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18517">
        <property type="entry name" value="LZ3wCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03962">
        <property type="entry name" value="Mnd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mnd1 HTH" evidence="5">
        <location>
            <begin position="68"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Leucine zipper with capping helix" evidence="6">
        <location>
            <begin position="203"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="131"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF18517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0794183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="257" mass="29884" checksum="A85C587DC9740751" modified="2020-02-26" version="1">MRSSIFAWRTSKMSAEMNRWNSSRSCIINFLPNFNVSSRCSKNCFIAGSLEIKMSRKGISTEEKKARMLQLFYERKEFFQLKDLEKIAPKEKGIIVNSVKDVLQSLVDDGAVDTDKIGTSIYFWAFPSKALNSKKRKANELEDQLAEANKKLKLTVDSITELKSGCDNSRERNGYLDEIMELEIQKKVLDKDMEKYADCNPITLRRMQEQTTKLKEAANRWTDNVFNVKSWCKRKFNMEDQELDKQFGIPADFDYVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AAN8</accession>
    <name>A0A5N4AAN8_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_11234</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0794395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AAN8"/>
    <dbReference type="OrthoDB" id="6769536at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="622"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="783"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="939"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1036"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1222"/>
            <end position="1270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1498"/>
            <end position="1520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="629"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="783"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="821"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="848"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="949"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1036"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1048"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1229"/>
            <end position="1239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1258"/>
            <end position="1270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1511"/>
            <end position="1520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0794395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="2024" mass="226365" checksum="9B03C172A0625B97" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AAY3</accession>
    <name>A0A5N4AAY3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PPYR_11257</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0794418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AAY3"/>
    <dbReference type="FunCoup" id="A0A5N4AAY3">
        <property type="interactions" value="11"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AAY3"/>
    <dbReference type="OrthoDB" id="10044855at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51225">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="7">
        <location>
            <begin position="36"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0794418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="182" mass="20343" checksum="D1F074C7F88520F0" modified="2020-02-26" version="1">MIGGRGPIVTVHRTTGGDKGIKCCCCMCCTCFNWTFLKTQHGILKIVEVILGFFCQTLAINYGLGYDGAIGKSYHSFLTTCSWSLMTSIILLFCYVFSEKSISLIRQSFFETAFNITACVSFLSASSYLGFAVNAFLYPMYIITPFFQVYPAMTAAYVLGFISGAVHGYDAYKSYRYFKGYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AD86</accession>
    <name>A0A5N4AD86_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PPYR_12110</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0795271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AD86"/>
    <dbReference type="FunCoup" id="A0A5N4AD86">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AD86"/>
    <dbReference type="OrthoDB" id="5985669at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051856">
        <property type="entry name" value="CSR-E3_Ligase_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012858">
        <property type="entry name" value="DC_STAMP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058842">
        <property type="entry name" value="DCST1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21041">
        <property type="entry name" value="DENDRITIC CELL-SPECIFIC TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21041:SF17">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE DCST1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07782">
        <property type="entry name" value="DC_STAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26037">
        <property type="entry name" value="zf-RING_DCST1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="536"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="domain" description="Dendritic cell-specific transmembrane protein-like" evidence="6">
        <location>
            <begin position="391"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="domain" description="E3 ubiquitin-protein ligase DCST1-like C-terminal" evidence="7">
        <location>
            <begin position="637"/>
            <end position="686"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF26037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0795271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="703" mass="81499" checksum="FD4EEF0CE8848B49" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ADU1</accession>
    <name>A0A5N4ADU1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_12323</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0795484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ADU1"/>
    <dbReference type="InParanoid" id="A0A5N4ADU1"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0795484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="312" mass="35656" checksum="82CF430D7492F75C" modified="2020-02-26" version="1">MDYEDIMNYTTVDSRTEPTTSVKDSWINRIEPHEVILFTCCTAAFFADLAIIFTMLCFKQLRTALNVFIVSWAILDICAVLVTPVGYRLVSILNHLNVCFLLQMGLVLHFLIIVSVFIIFISWCIIAYFSKFSKWIGVYYKITMALIWGILLIFLIILSTGCLGHKFNDNAGKGGYGTLALLLMSILTIRFLNVLRKNKEQSLEHSKLPLTLCTAFVLCHAFALGSYAMSQFLWLWNPIPIIISACFVYCNSVVTFSVLFFYDKPFQLHVRKIIHCTPRGTGRSFNEGERLDQEAFSEVSFHCPTEELRTNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ADY9</accession>
    <name>A0A5N4ADY9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">GATA-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PPYR_12382</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0795543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ADY9"/>
    <dbReference type="FunCoup" id="A0A5N4ADY9">
        <property type="interactions" value="72"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4ADY9"/>
    <dbReference type="OrthoDB" id="515401at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045165">
        <property type="term" value="P:cell fate commitment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000036">
        <property type="entry name" value="Endothelial transcription factor GATA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000032">
        <property type="entry name" value="Transcription factor GATA-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016374">
        <property type="entry name" value="TF_GATA-2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039355">
        <property type="entry name" value="Transcription_factor_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071:SF281">
        <property type="entry name" value="BOX A-BINDING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071">
        <property type="entry name" value="TRANSCRIPTION FACTOR GATA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003027">
        <property type="entry name" value="TF_GATA-1/2/3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00619">
        <property type="entry name" value="GATAZNFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="13">
        <location>
            <begin position="255"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="GATA-type" evidence="13">
        <location>
            <begin position="312"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="GATA-type 1" evidence="10">
        <location>
            <begin position="261"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="GATA-type 2" evidence="10">
        <location>
            <begin position="318"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="109"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="232"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="360"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="436"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="232"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="365"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="445"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR003027-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAB0795543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="484" mass="51485" checksum="A1E017D99838EC3F" modified="2020-02-26" version="1">MIMEMTNDSAAVGRWYESPRTGTSASPAQGGLEGSSSDLNSSVAEHMGFFLDPSGTQRAARYYHQSMHSPYGSVAGHASRMSSSQVCRPHFHAPLHPWLSDGAKPLTHSGPWVPFGGADPDSKSQSPSSGHAQPPNLFSFPPTPPKDSTPDSVVPTSGGSEYQSAVAVAMGAFMHDNQQSCALDVKPSTVSNKQREGSEYEGASSGMFNGNFESSYGAAYGHGIHGAAYSPQTKQSLVSQNAQSPNKPRNKSRTSAEGRECVNCGATSTPLWRRDGTGHYLCNACGLYYKMNGQNRPLIKPKRRLSLQSAARRAGTSCANCKTTTTTLWRRNQNGEPVCNACGLYYKLHNVNRPLTMKKEGIQTRNRKLSSKSKKKKGGGSCLSLGGVMSDMMKPLDSSKGAFGGGGFGGGMGGGHPHLNPALHPHHAMSHWYQHSGHHQGFVSGPPPPAPPPTASYHHHMSSLSAAGLGLTSNGMAGWRSEYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-06-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AEL4</accession>
    <name>A0A5N4AEL4_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_09805</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0795744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AEL4"/>
    <dbReference type="InParanoid" id="A0A5N4AEL4"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0795744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="122" mass="14468" checksum="F3570DF91FB0E3B1" modified="2020-02-26" version="1">MHLHLHGPLLRLPVAYTKYVQVEGICIMHVNLKTHHPKYHAIKNELLLSHLWNFCLQQLIVDRPLYESQQKIYGKTKLNIFKGDFYKAGRGLNWIKTYFKGHSNVLKNITHWWRAPENLTPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AFV8</accession>
    <name>A0A5N4AFV8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_10276</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AFV8"/>
    <dbReference type="InParanoid" id="A0A5N4AFV8"/>
    <dbReference type="OrthoDB" id="4142200at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050549">
        <property type="entry name" value="MFS_Trehalose_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021:SF24">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="263"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="327"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="359"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="427"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="11"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0796215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="482" mass="55149" checksum="E39D39368D6DCAF0" modified="2020-02-26" version="1">MRLYFLPQILSSIAVATFCFLNGLELSYLSILIPYFTNNDTRVENSFAMSDNEKSWLLSIGPIVKPLGCVLAGLVMDHIGRLNTLRVAVLPWSIGWLLIAKASSFLMIAAGFTITIFSFPWLLITAVTYITEISSPSVRGMLVNLKTIFWCLGSMAMFLLGAFLHWRTIAWINCLLPLAPLFLSLLLKESMLWLVTRGRFEDAKKSLVYFNRYRKTSRDENFDCVIDRKLLMIQTLHDRYRSINLSLLQKLKFFLQPSGYKRVLMVAGLEFFQNLSGSIIVFSNIMVFFNEFGTTINPYAVGIYLGLTKLVITFCNIWLLKTFRFRIILIASYLIISGCLVAFGLYIDFNPKDSSIYQWIPLCALILYSNSMVVGPYSVPVVLTPSVYPTHIRGTGQSVSSIIGHMLEFFMIQSYYAIKKGVKQSHILYFMSFSSLIACVYIYSWVVETRQKTFLEIENYFVKKDNKSNPRSLEEQDPCLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AGC7</accession>
    <name>A0A5N4AGC7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FK506-binding protein</fullName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PPYR_10407</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the FKBP-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AGC7"/>
    <dbReference type="FunCoup" id="A0A5N4AGC7">
        <property type="interactions" value="154"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AGC7"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000006">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.340">
        <property type="entry name" value="Nucleoplasmin core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041232">
        <property type="entry name" value="NPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023566">
        <property type="entry name" value="PPIase_Fpr3/Fpr4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43811:SF19">
        <property type="entry name" value="39 KDA FK506-BINDING NUCLEAR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43811">
        <property type="entry name" value="FKBP-TYPE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17800">
        <property type="entry name" value="NPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001473">
        <property type="entry name" value="FK506-bp_FPR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 5" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="7">
        <location>
            <begin position="282"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="103"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="165"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="103"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="168"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR001473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0796346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="370" mass="41507" checksum="2C991E1E943C4FE8" modified="2020-02-26" version="1">MFWGLIMEPKRRYSQSVKRAFHISMAALDLFSADDNPTQLMLFFENRNYLLCTLQKGHTVQCPLDLNFEAGDEVVFATNGNCNIHLSGYLQEDQLDYLDGDLEEEEEEGEADEEEVAQKQVSKQKRLSLSPNEKRTYFLTCSGVSSNGLFLAASKKSKLESILKEDFDTNDEDDDSYVMSSDDDAEEEEDEDGEEEEEEDSDDDDEEDEEVVPQPPIKVMNGEKPKSLKKQKEKAKNEKPKNEAPAAKQKDQKNAPQQKRTVEGGVVIQDIRVGEGAIAKSGKVVQVYYEGRLKNNNKLFDQSNKGSGFKFRLGKQEVIKGWDVGVVGMKVGGRRRITCPAPMAYGQKGSPPAIPPNATLIFDVELKNVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AGG4</accession>
    <name>A0A5N4AGG4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">ADP/ATP translocase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">ADP,ATP carrier protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PPYR_10511</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">1611_PpyrPB1</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell. Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane.</text>
    </comment>
    <comment type="function">
        <text evidence="16">Catalyzes the exchange of ADP and ATP across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ADP(in) + ATP(out) = ADP(out) + ATP(in)</text>
            <dbReference type="Rhea" id="RHEA:34999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:35000"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 16">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Membrane</location>
            <topology evidence="16">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AGG4"/>
    <dbReference type="InParanoid" id="A0A5N4AGG4"/>
    <dbReference type="OrthoDB" id="270584at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005471">
        <property type="term" value="F:ATP:ADP antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140021">
        <property type="term" value="P:mitochondrial ADP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990544">
        <property type="term" value="P:mitochondrial ATP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901029">
        <property type="term" value="P:negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000002">
        <property type="entry name" value="Putative ADP/ATP translocase 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002113">
        <property type="entry name" value="ADT_euk_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635">
        <property type="entry name" value="ADP,ATP CARRIER PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635:SF40">
        <property type="entry name" value="ADP_ATP TRANSLOCASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00927">
        <property type="entry name" value="ADPTRNSLCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0050">Antiport</keyword>
    <keyword evidence="11 14 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="6"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="111"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="207"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU368008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAB0796450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="297" mass="33011" checksum="F5A853FB784DB0FF" modified="2020-02-26" version="1">MSAETNKFLKDFLAGGISAAVSKTVVAPIERVKLLLQVQAVSKQIPEDKRYKGMVDCFLRIPKEQGFTSFWRGNLANVVRYFPTQALNFAFKDIYQNMFLSGINKKTQFWRYFMGNLASGGAAGATSLCFVYPLDYARTRLAADVGGGKTRLYSGLMDCLMKTMKSDGLIGMYRGFVVSVQGIIIYRATYFGCFDTAKGMLPDPKTTPFLVTFGIAQAVTTFAGITSYPFDTVRRRMMMQSGRAKGDLLYKNTADCWIKIFRQEGIGAFFKGAFSNVIRGMGGALVLVLYDELKDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AH97</accession>
    <name>A0A5N4AH97_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">UDP-glucuronosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_10730</name>
        <name evidence="6" type="ORF">PPYR_11934</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0795095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AH97"/>
    <dbReference type="FunCoup" id="A0A5N4AH97">
        <property type="interactions" value="289"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AH97"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000050">
        <property type="entry name" value="UDP-glucuronosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF159">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036147755" description="UDP-glucuronosyltransferase" evidence="5">
        <location>
            <begin position="19"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="470"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0795095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0796669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="505" mass="58126" checksum="52A9F3115DEDE846" modified="2020-02-26" version="1">MLYSIIICFLVIVNTVDSARILGVYPLPSRSDFKLCDRLFRELALRGHDVTVIIPFEDNRPMANFRQIVLANAASASTENQRIFFEVPTRNIFEKTIWLDSFGIQFTEMTLNDTNVKQFLQEQNSFDLVIVQYLKSDAFHGFCYHYGAPCVMFNSVTSPSFFRDNVGSIASPAYVPELFLALTGEMNIWLRSYNALVHVLTKLSLHLYFYPHQNRLLQKYFPGAPHLDDLIYNVSLVLLNGHTSVSEAIQYTPNTINIAGFHVSTSNELPEDLQRYLDQAVDGAILFSMGSNLPSKYLDVAKRDIFLKTFSKLKQKVLWKWDGVRLPNKSENVLTRHWFPQQEVLAHPNVVLFVTHFGLLSTIESLYHAKPMLGIPVFADQVSNAALSQARGYGRYIPFQDLSEENFYDNIHEMLSNPRYSTNAKKQMKIMHDRPQSAMENAMYWVEYVVRHKGAPHLRSSGVTLKWYQYYLVDVMVFCAAFGVVFIYLTIQIFVFIYQNVKVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AIF7</accession>
    <name>A0A5N4AIF7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phospholipid/glycerol acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_08060</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GPAT/DAPAT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AIF7"/>
    <dbReference type="FunCoup" id="A0A5N4AIF7">
        <property type="interactions" value="740"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AIF7"/>
    <dbReference type="OrthoDB" id="5962536at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004366">
        <property type="term" value="F:glycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07993">
        <property type="entry name" value="LPLAT_DHAPAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022284">
        <property type="entry name" value="GPAT/DHAPAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045520">
        <property type="entry name" value="GPAT/DHAPAT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041728">
        <property type="entry name" value="GPAT/DHAPAT_LPLAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12563:SF23">
        <property type="entry name" value="BCDNA.GH07066"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12563">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19277">
        <property type="entry name" value="GPAT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="6">
        <location>
            <begin position="269"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0797066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="837" mass="95453" checksum="E0836171B55566A5" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AJA9</accession>
    <name>A0A5N4AJA9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">MAP/microtubule affinity-regulating kinase 3</fullName>
            <ecNumber evidence="5">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">Serine/threonine-protein kinase par-1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">PPYR_08411</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">1611_PpyrPB1</strain>
            <tissue evidence="27">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Serine/threonine-protein kinase. Involved in the specific phosphorylation of microtubule-associated proteins for MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU. Phosphorylates CDC25C on 'Ser-216'. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Regulates localization and activity of MITF by mediating its phosphorylation, promoting subsequent interaction between MITF and 14-3-3 and retention in the cytosol. Negatively regulates the Hippo signaling pathway and antagonizes the phosphorylation of LATS1. Cooperates with DLG5 to inhibit the kinase activity of STK3/MST2 toward LATS1. Phosphorylates PKP2 and KSR1.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="19">Interacts with MAPT/TAU. Interacts with DLG5 (via coiled-coil domain). Interacts with STK3/MST2 and STK4/MST1 in the presence of DLG5. Interacts with YWHAB, YWHAG, YWHAQ and YWHAZ. Interacts with PKP2 (via N-terminus). Interacts with CDC25C. Interacts with KSR1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cell cortex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="27">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="5"/>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="F:protein serine kinase activity"/>
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        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050321">
        <property type="term" value="F:tau-protein kinase activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:intracellular signal transduction"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <property type="entry name" value="MARK1-3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="STKc_MARK"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="KP78b, isoform A"/>
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        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
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    </dbReference>
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        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
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        <property type="entry name" value="Kinase associated domain 1, KA1"/>
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        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
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    </dbReference>
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        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="KA1_dom"/>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="MARK1-4_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
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    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
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        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF82">
        <property type="entry name" value="KP78A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02149">
        <property type="entry name" value="KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103243">
        <property type="entry name" value="KA1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50032">
        <property type="entry name" value="KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 22" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 22" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="24">
        <location>
            <begin position="95"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="25">
        <location>
            <begin position="365"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="KA1" evidence="26">
        <location>
            <begin position="761"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="431"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="679"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="22"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="486"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="539"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="615"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="635"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004316"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00006234"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00054424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00063680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00071529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00074935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="KAB0797417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="810" mass="88803" checksum="51A5D89438B12836" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AK83</accession>
    <name>A0A5N4AK83_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_08714</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="InParanoid" id="A0A5N4AK83"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.960.10">
        <property type="entry name" value="VSR Endonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0797721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="187" mass="21875" checksum="6F1D6EA72B7EC13C" modified="2020-02-26" version="1">MQKEIVSYCISDVNILTLACLKFRELLIKSGNVCPYTEACTIASACNKLFRRNFLKTDTIGLIPRQGYRYRDNQSKVAIHWLIWEEKVRGIDIVHAAKQKEIVIGGLPVDGYCPQTNQVFEMMGCFYHGCVKCFKNDRDKPIHSNSYETMDLRYENTLSKINHLNQLGYEVIVKWESKKRKYFEQIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AL48</accession>
    <name>A0A5N4AL48_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_08986</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AL48"/>
    <dbReference type="FunCoup" id="A0A5N4AL48">
        <property type="interactions" value="24"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AL48"/>
    <dbReference type="OrthoDB" id="67700at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031045">
        <property type="term" value="C:dense core granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048791">
        <property type="term" value="P:calcium ion-regulated exocytosis of neurotransmitter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048488">
        <property type="term" value="P:synaptic vesicle endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08387">
        <property type="entry name" value="C2A_Synaptotagmin-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00276">
        <property type="entry name" value="C2B_Synaptotagmin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000211">
        <property type="entry name" value="synaptotagmin-5 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024:SF373">
        <property type="entry name" value="MIP05618P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024">
        <property type="entry name" value="SYNAPTOTAGMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00360">
        <property type="entry name" value="C2DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="3">
        <location>
            <begin position="182"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="3">
        <location>
            <begin position="314"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="112"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0797993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="462" mass="52348" checksum="607E3AA72E1799CD" modified="2020-02-26" version="1">MEMSEDEEKEPSAYVVAFLYGILSFVCVILLVLLIFVACSRKYRLNWFEKNLLESADNKDSHSQEPLVQELIQGSSKSLCTNYGEEAYWMPTSSQKHSSLCQSDNERDETSPECSIPESPISSSSYQPFSAPIPLARNGNQIILTNTSPVRPKLASMQSKLDHTKIDYSLYQTESPSEPTNMRGSLHVTLFYEPIAEILTVRLIEAQDLEARDFSGTADPYAKIRLLPDRTNVWQTRIHKKTLNPVFDEDFVFEVKAATLGRHTLEVVLYNFDAYSRHYSIGGVQLPLANIDLSEKVDLWKGLSPSFEHDARLDLGELMVSLAYLPSAERLTVVVIKARNLRMVDDTRNSSDPYVKVSIMQGDKKIKKRKTGVHRNTVCPIFNEALTFNISKSQLKRCYIEFSVLHDSLLGASELLGKARVGQTAECKRREKEYFAEIFQSTTATAQWLPLSDPRIVPQKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ALB3</accession>
    <name>A0A5N4ALB3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_09056</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ALB3"/>
    <dbReference type="InParanoid" id="A0A5N4ALB3"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF9">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="276"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="298"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="240"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="240"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0798063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1178" mass="135110" checksum="2542BEFE6B30528C" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AN01</accession>
    <name>A0A5N4AN01_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein-lysine N-methyltransferase SMYD4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">SET and MYND domain-containing protein 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PPYR_09702</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Protein-lysine N-methyltransferase. Monomethylates PRMT5, modulating its transcriptional activity. May also act as a histone methyltransferase. Plays a critical role in cardiac development. Acts as a key epigenetic regulator of gene expression during cardiac development via its dual activities as a methyltransferase and negative regulator of HDAC1.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AN01"/>
    <dbReference type="FunCoup" id="A0A5N4AN01">
        <property type="interactions" value="1336"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AN01"/>
    <dbReference type="OrthoDB" id="1028014at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042826">
        <property type="term" value="F:histone deacetylase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042051">
        <property type="term" value="P:compound eye photoreceptor development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10536">
        <property type="entry name" value="SET_SMYD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052097">
        <property type="entry name" value="SET-MYND_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044421">
        <property type="entry name" value="SMYD4_SET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46165">
        <property type="entry name" value="SET AND MYND DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46165:SF7">
        <property type="entry name" value="SET AND MYND DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SET" evidence="11">
        <location>
            <begin position="206"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="MYND-type" evidence="12">
        <location>
            <begin position="267"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00093423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00093635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00093680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAB0798709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="655" mass="75108" checksum="7D8A3BEC08B75E4A" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AN83</accession>
    <name>A0A5N4AN83_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_06669</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0798789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AN83"/>
    <dbReference type="InParanoid" id="A0A5N4AN83"/>
    <dbReference type="OrthoDB" id="6431331at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF14">
        <property type="entry name" value="SERINE HYDROLASE-LIKE PROTEIN DDB_G0286239"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="27"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0798789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="299" mass="33911" checksum="A60A00F778E3938B" modified="2020-02-26" version="1">MEIKEFEIPVPWGHVAVKAWGVETNTPVLTIHGVSDNVGSFDRLIPHLPDTFYYICIDLPGHGRSSPYPPYLLITALNTILTMKLVVDYLNRKEYIIMGHSWGGQCAILFTQLYPEYILKLVVLDCFYLFPIEAKNFKESLRTRIDGLIKLSKNTANRKPAYFTYNDAINKMIDGRFAGMVLSKEAAEPIANRGLVDQGNGLYSFAVDPRMRYFTNLMTSFEYLGEIVNKYPLVCPVLIIYCSDSDFQYYVLKSVVNEYQKCKNISIVQVHGSHDVHNNTPEIVAPLVSTFLTSIASKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ANG4</accession>
    <name>A0A5N4ANG4_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_06765</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0798885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ANG4"/>
    <dbReference type="InParanoid" id="A0A5N4ANG4"/>
    <dbReference type="OrthoDB" id="6727025at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0798885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="155" mass="18093" checksum="4E663E8A30F7D026" modified="2020-02-26" version="1">MRDEFAFTTSMNTEESKETCNATEEMKYKGIHTSTNGYYGYQFVQANQTEEICESMEIQYNNADPDSDIQFNNFIRPEDRLCCDPLAANMREPVNRKRRLNYDNAGDCKKRRESDIVTDKAATKKKTEIKPPTDDLTETLLQEIHGCPIYHWQEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AQC3</accession>
    <name>A0A5N4AQC3_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PPYR_07414</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AQC3"/>
    <dbReference type="InParanoid" id="A0A5N4AQC3"/>
    <dbReference type="OrthoDB" id="10253869at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046949">
        <property type="term" value="P:fatty-acyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000007">
        <property type="entry name" value="4-coumarate--CoA ligase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF353">
        <property type="entry name" value="GH16244P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="4">
        <location>
            <begin position="51"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="5">
        <location>
            <begin position="473"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0799534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="557" mass="61774" checksum="939E87F76F3F4225" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-06-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AQT4</accession>
    <name>A0A5N4AQT4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CBM39 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_07567</name>
        <name evidence="4" type="ORF">PPYR_07568</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AQT4"/>
    <dbReference type="InParanoid" id="A0A5N4AQT4"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2140">
        <property type="entry name" value="Beta-1,3-glucan-recognition protein, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031756">
        <property type="entry name" value="BGBP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043030">
        <property type="entry name" value="BGBP_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15886">
        <property type="entry name" value="CBM39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51969">
        <property type="entry name" value="CBM39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033859658" description="CBM39 domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="CBM39" evidence="2">
        <location>
            <begin position="21"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0799687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0799688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="249" mass="28260" checksum="525F15312F124465" modified="2020-02-26" version="1">MSIKLAVLLFAIIFQKSCQSYLIPKPEITVYSPKGFSVSIPHTHGISSVTFQGNINRELRNFNDIDLLSNVTKVENGKWIIRDFNSRLQSGDLISYRLLVVKKCLRYWFQGERFLVKEVVNLLPSAPPIPVEKDHEACMRSIHDLTQTTIQQKALIEKLESKIQHLSNYVNSQNGRSLILTGRITKEGYPSDTVTFVLNELLNLDTKVLSAHRNTDGSITFEVPTSEDKSDILEALKKSRSTRISIKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ARN7</accession>
    <name>A0A5N4ARN7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PPYR_07871</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ARN7"/>
    <dbReference type="FunCoup" id="A0A5N4ARN7">
        <property type="interactions" value="183"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4ARN7"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008046">
        <property type="term" value="F:axon guidance receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050808">
        <property type="term" value="P:synapse organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000032">
        <property type="entry name" value="palladin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050958">
        <property type="entry name" value="Cell_Adh-Cytoskel_Orgn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080">
        <property type="entry name" value="CONTACTIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080:SF8">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="548"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="8"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="224"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="347"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="446"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0799991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="865" mass="98546" checksum="63C482A3F14DA199" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ARP6</accession>
    <name>A0A5N4ARP6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PPYR_07877</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ARP6"/>
    <dbReference type="InParanoid" id="A0A5N4ARP6"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF158">
        <property type="entry name" value="GH23626P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024363740" description="Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein" evidence="5">
        <location>
            <begin position="19"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="7">
        <location>
            <begin position="313"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="547"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="591"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0799997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="612" mass="68479" checksum="0A5CF0A704F31B48" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ASI4</accession>
    <name>A0A5N4ASI4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Protein krueppel</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PPYR_06037</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">1611_PpyrPB1</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000004">
        <property type="protein sequence ID" value="KAB0800297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ASI4"/>
    <dbReference type="FunCoup" id="A0A5N4ASI4">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4ASI4"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000322">
        <property type="entry name" value="GDNF-inducible zinc finger protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000765">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002005">
        <property type="entry name" value="Zinc finger protein 200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000358">
        <property type="entry name" value="zinc finger protein 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001049">
        <property type="entry name" value="zinc finger protein 319"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000303">
        <property type="entry name" value="Zinc finger protein 41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000110">
        <property type="entry name" value="Zinc finger protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012934">
        <property type="entry name" value="Znf_AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24409">
        <property type="entry name" value="ZINC FINGER PROTEIN 142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24409:SF331">
        <property type="entry name" value="ZINC FINGER PROTEIN 322A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07776">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00868">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51915">
        <property type="entry name" value="ZAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZAD" evidence="14">
        <location>
            <begin position="5"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="187"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="250"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="283"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="311"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="339"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="367"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="395"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="423"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="451"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="479"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="507"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAB0800297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="533" mass="60235" checksum="2A964E9FD19573ED" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-09-13" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ASU3</accession>
    <name>A0A5N4ASU3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_06127</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000004">
        <property type="protein sequence ID" value="KAB0800387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ASU3"/>
    <dbReference type="InParanoid" id="A0A5N4ASU3"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0800387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="91" mass="10442" checksum="9B2362AEC97816BC" modified="2020-02-26" version="1">MLTELANESDHVEAVNDYIYLGQIIKINKENQPTEVTRGTRLAWAGFGKLKWVLKNKKIPQYLKTRVFDQCILPILKHACQTWTLTKANAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AT68</accession>
    <name>A0A5N4AT68_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cyclic nucleotide-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_06271</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000004">
        <property type="protein sequence ID" value="KAB0800531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AT68"/>
    <dbReference type="InParanoid" id="A0A5N4AT68"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098855">
        <property type="term" value="C:HCN channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003254">
        <property type="term" value="P:regulation of membrane depolarization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035725">
        <property type="term" value="P:sodium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.630">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051413">
        <property type="entry name" value="K/Na_HCN_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45689:SF14">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45689">
        <property type="entry name" value="I[[H]] CHANNEL, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="317"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="419"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0800531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="570" mass="67207" checksum="ECDCCAFD18797096" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-06-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ATU1</accession>
    <name>A0A5N4ATU1_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_06465</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000004">
        <property type="protein sequence ID" value="KAB0800726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ATU1"/>
    <dbReference type="InParanoid" id="A0A5N4ATU1"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0800726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="74" mass="8850" checksum="F899770D46622AC6" modified="2020-02-26" version="1">MKSIDVLNVPQSRRNLYRHLQAVRRHFWKRWPKECTYVGFSGTTKMEPGDRTPQCWILSSNQRRSVTTITKEIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-06-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AVI4</accession>
    <name>A0A5N4AVI4_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_05690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000003">
        <property type="protein sequence ID" value="KAB0801336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AVI4"/>
    <dbReference type="InParanoid" id="A0A5N4AVI4"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0801336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="100" mass="11134" checksum="5259BE2358496287" modified="2020-02-26" version="1">MYYNDVCYDSPEKIVNAFAMYFGSVYLSDDGYNDSANKDNEFNNLPCINIGSVLESQVIQAISKLPNKFTAGPDLVPSFLIKDCRGVLVQPLLLLFNLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AWL1</accession>
    <name>A0A5N4AWL1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_03941</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0801755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AWL1"/>
    <dbReference type="FunCoup" id="A0A5N4AWL1">
        <property type="interactions" value="1743"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AWL1"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12671">
        <property type="entry name" value="RRM_CSTF2_CSTF2T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.630:FF:000001">
        <property type="entry name" value="Cleavage stimulation factor subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000061">
        <property type="entry name" value="cleavage stimulation factor subunit 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025742">
        <property type="entry name" value="CSTF2_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45735">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45735:SF2">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14327">
        <property type="entry name" value="CSTF2_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="14"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="253"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="280"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0801755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="293" mass="32625" checksum="78B2E76D46226720" modified="2020-02-26" version="1">MDNLDANIMDKSMRSVFVGNIPYEATEEKLKDIFGEVGQVLSFKLVFDRETGKPKGYGFCEYRDQETALSAMRNLNGYEIGGRNLRVDNACTEKSRMEMQNLLNQPPVENPYGEPIQAEKAPEAISKAVASLPPEQMFELMKQMKLCVQNNPSEARNMLLQNPQLAYALLQAQVVMRIVDPQTACSMLHPETSVPPPLLPNEKPIHGPVPLNNNFIAQIQQPPIIRQEFPPIPPLLQNSQPPVFTGQDVDLRSLDMRGPGDPRLGGVRIGGDQDMRPLPVQLPNPLPPPVSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2024-01-24" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AWM4</accession>
    <name>A0A5N4AWM4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ZSWIM3 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_03927</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0801741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AWM4"/>
    <dbReference type="InParanoid" id="A0A5N4AWM4"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048325">
        <property type="entry name" value="ZSWIM3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040854">
        <property type="entry name" value="ZSWIM9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47086">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47086:SF4">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21599">
        <property type="entry name" value="ZSWIM3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ZSWIM3 N-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="3"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0801741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="166" mass="19125" checksum="6F25F84955380DAE" modified="2020-02-26" version="1">MKEGALFATLEQLEQEIKEYEATNYVTLQKRDSCLLSKAVKKYPRAARGNRNLKYYYVEYTCSKGGKRFKSRGKAIRKSSTMYEGCPMKIKFVLAEDGKHLLCKLLHDQHNHIRNKVGTYLIKATCYVDLLHKMLPLLGTYNTACKKNWVVHRISNTNSANIDLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AYV0</accession>
    <name>A0A5N4AYV0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein sarah</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_04705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RCAN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AYV0"/>
    <dbReference type="FunCoup" id="A0A5N4AYV0">
        <property type="interactions" value="921"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AYV0"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008597">
        <property type="term" value="F:calcium-dependent protein serine/threonine phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019722">
        <property type="term" value="P:calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007617">
        <property type="term" value="P:mating behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12434">
        <property type="entry name" value="RRM_RCAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000092">
        <property type="entry name" value="Calcipressin-2 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006931">
        <property type="entry name" value="Calcipressin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10300">
        <property type="entry name" value="CALCIPRESSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10300:SF14">
        <property type="entry name" value="PROTEIN SARAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04847">
        <property type="entry name" value="Calcipressin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0802519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="223" mass="24760" checksum="DD6D94EBFD9C38EF" modified="2020-02-26" version="1">MAENNCELNQDDIIINDQDGLPNVHPNLLAEATVDSPDRTTDDEFEDLPTSLIVTNIHDDVFINPDRKTELEELFRMYDSEVTFQWLRSFKRLRVNFQTPLAAASARIQLHQYPIKESVITCYFAQPVTPVKNSSLQPPAPFKQFLISPPSSPPLDWEPRPEGEPIINHDLLAALATLTPGSSHEVHPPSPGQPGIVVHTALGAVAESDAKPKIIQTSCPQRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AZL5</accession>
    <name>A0A5N4AZL5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Calponin-homology (CH) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_04894</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AZL5"/>
    <dbReference type="FunCoup" id="A0A5N4AZL5">
        <property type="interactions" value="394"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AZL5"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022008">
        <property type="term" value="P:neurogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="CH_NAV2-like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="CH_dom"/>
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        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039041">
        <property type="entry name" value="Nav/unc-53"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12784:SF28">
        <property type="entry name" value="PROTEIN SICKIE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="STEERIN"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="3">
        <location>
            <begin position="177"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="28"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="310"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="497"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="573"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="758"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1099"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1150"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="379"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="441"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="534"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="574"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="598"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="806"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="853"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1099"/>
            <end position="1119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0802708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1210" mass="131666" checksum="325D0B9ECA840758" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AZP7</accession>
    <name>A0A5N4AZP7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">TEA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PPYR_04949</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="term" value="P:embryonic organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Transcriptional enhancer factor TEF-1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TEA/ATTS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TEA/ATTS_dom"/>
    </dbReference>
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        <property type="entry name" value="TEA/ATTS_sf"/>
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        <property type="entry name" value="TEC1_TEAD_TF"/>
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        <property type="entry name" value="TEF_metazoa"/>
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        <property type="entry name" value="YBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11834:SF0">
        <property type="entry name" value="PROTEIN SCALLOPED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11834">
        <property type="entry name" value="TRANSCRIPTIONAL ENHANCER FACTOR TEF RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="YBD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00065">
        <property type="entry name" value="TEADOMAIN"/>
    </dbReference>
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        <property type="entry name" value="TEA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TEA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TEA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TEA" evidence="9">
        <location>
            <begin position="3"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="TEA" evidence="7">
        <location>
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            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
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            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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    </evidence>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0802763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="353" mass="40396" checksum="887CD577FB396864" modified="2020-02-26" version="1">MAAADAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQVSSHIQVLARRKLREIQAKLKVQFWQPGLQPGTSQDVKPFQQPPYPGKPATAVSSGEVGPLQAPPPPPWEGRAIATHKLRLVEFSAFMEQHRDTDNTYHKHLFVHIGGTATYADPLLEAVDVRQIYDKFPEKKGGLKELYDKGPQSAFFLVKFWADLNTNIQDEAGAFYGVTSQYESNENMTITCSTKVCSFGKQVVEKVETEYARYENGRFIYRIHRSPMCEYMINFIHKLKHLPEKYMMNSVLENFTILQVVSNRDTQETLLCTAYVFEVSTSEHGAQHHIYRLVKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B0M3</accession>
    <name>A0A5N4B0M3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DDE-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_00119</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B0M3"/>
    <dbReference type="InParanoid" id="A0A5N4B0M3"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF74">
        <property type="entry name" value="POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
        <property type="entry name" value="HTH_psq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH psq-type" evidence="3">
        <location>
            <begin position="2"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="DDE-1" evidence="2">
        <location>
            <begin position="197"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="415"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="657"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="416"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="665"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="714"/>
            <end position="724"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0803149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="724" mass="81512" checksum="768E895DC484511E" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B165</accession>
    <name>A0A5N4B165_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PPYR_00110</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B165"/>
    <dbReference type="FunCoup" id="A0A5N4B165">
        <property type="interactions" value="78"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4B165"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000077">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050430">
        <property type="entry name" value="Peptidase_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276:SF91">
        <property type="entry name" value="AT26814P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276">
        <property type="entry name" value="POLYSERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024374598" description="Peptidase S1 domain-containing protein" evidence="9">
        <location>
            <begin position="17"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="10">
        <location>
            <begin position="31"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0803140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="326" mass="34592" checksum="6ADBDDE37BDA5333" modified="2020-02-26" version="1">MFRLVLFLTAVTLAAGAKLQRSTPPRLDGKIVGGKPVKIEDYPYQVSLQYYGSHICGGSIIGPNKVLTAAHCTSGSSASSLSIRHSSTYKGSEGVVIKVASIAQNPAYNPSTISDDVTVLTLAEPIKDSDIGKPIAMVEANATEGDREAVCTGWGTLSSGGSSPRQLQAVDVKEVDRKECNTSYGGGITDTMICFGSPGKDSCQGDSGGPLVVGEKQVGIVSWGYGCAHPEYPAEKEAYHGKQSNPADPGIPQRLMTDHRSPSWTSSGGGTTGLIRGEDIATHDEHLQVVLDDNARWFNKKPVPMLILGEVLTLTWNYARTQKNLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B2X0</accession>
    <name>A0A5N4B2X0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Peptidase M13 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PPYR_00922</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B2X0"/>
    <dbReference type="InParanoid" id="A0A5N4B2X0"/>
    <dbReference type="OrthoDB" id="6658958at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF167">
        <property type="entry name" value="FI17812P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="11">
        <location>
            <begin position="94"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="10">
        <location>
            <begin position="525"/>
            <end position="725"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAB0803952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="727" mass="85021" checksum="7155EE46B4E35BF4" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B3M2</accession>
    <name>A0A5N4B3M2_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_01177</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B3M2"/>
    <dbReference type="InParanoid" id="A0A5N4B3M2"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF85">
        <property type="entry name" value="GH03217P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="8">
        <location>
            <begin position="160"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0804207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="365" mass="41633" checksum="A20BE44F9C5C5521" modified="2020-02-26" version="1">MDLQAIIALLVEDRDLAEPLNIIGNEVRERNAIPRNLNYYEETIPQYLGDLFVQHFRMSRECFGELSTVIGNNQRLQNSTIPMQKKILFTLWVLAKPESFLAAGDRFGLARSTAHGIFKDVVAVFVELLNRYITWPNNHDTAIRAFHDKSGGFPGVIGAIDGCHIQMKQPTANANDYYNRKQVHSVILQGICNHKKLFMDIYVGMPGRVHDAHVLRTSPVYGHLVNNNNTIMPHNCHILGDSAYPLMENLLTPFRDNGHLNEDQIRYNVKLSTIRAVIERAFGQLKGKFRRLKYLDIAEPDFATEIITAACVLHNFTLMWGEEMHDNEAIIEGENNHQEADDNDVVADHQNGVEKRNFIVNILRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B496</accession>
    <name>A0A5N4B496_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PPYR_01407</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B496"/>
    <dbReference type="InParanoid" id="A0A5N4B496"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF269">
        <property type="entry name" value="NUCLEASE HARBI1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024275290" description="DDE Tnp4 domain-containing protein" evidence="8">
        <location>
            <begin position="23"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="DDE Tnp4" evidence="9">
        <location>
            <begin position="178"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0804437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="427" mass="49010" checksum="80FF430851125043" modified="2020-02-26" version="1">MNRRKLITCMGFSLLLLSTAAAVVTMKEKRRRRWGIRPLNRERKRLGHFATLVIYMQNNDEEQFFKYTRLTPRYFHILLNIVKPFLTKQPRNKIFINPEERLMMTLHFLSQGTSMQDIAWNYYVGKTTVHCIIKETCQVLWERLQPIYLSTPSKNDFERTAAGFSRLWNMPNCIGAVNGKHVVIQSPKHSGSQFFSYKKTFSIVLMASCDAQYKFNMVDIGAAGSNHDGMVFRESGFGSALLEQRLQLPNPKVLPGSSILLPHFLVADQAFPLHQNIMRPYPGEHLVEKKRIFNYRLSRARRCIENAFGIVAQRWRVLRKTIIADLSTCEEIVKATVVLHNFILTEENGKKVYLPNGYADYIDGEGTLHEGRWRGTGQHLTGIGRIGTNNFSHRVGANRDLLADYFVSDAGSVPWQIQQIYAGSLPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B4A4</accession>
    <name>A0A5N4B4A4_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_01417</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B4A4"/>
    <dbReference type="InParanoid" id="A0A5N4B4A4"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0804447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="223" mass="24868" checksum="1E5BCE53EB4B469F" modified="2020-02-26" version="1">MIRGRGGRGGRRGRSRSRGRYDNTARSQSRGRGGSSTFESSLNELRWVLGNAGRRKNVTHAQWSKLAALLPNEYLKAHGGDRTVASVDLLYTNIAVEKEGKEVVIPNKCLSVVYSEENRGSVKELSLKNFKDCVYHSLPLLLDAVRSVQDTAFPVSSEAPPVAHAEIKMNERKLAGKKVDLFVEQEGCVFNHNEFYIISPTPSQISPSLMESLARKFEVFKMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B4B3</accession>
    <name>A0A5N4B4B3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_01402</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B4B3"/>
    <dbReference type="InParanoid" id="A0A5N4B4B3"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15489">
        <property type="entry name" value="PHD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052579">
        <property type="entry name" value="Zinc_finger_SWIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048324">
        <property type="entry name" value="ZSWIM1-3_RNaseH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048325">
        <property type="entry name" value="ZSWIM3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31569">
        <property type="entry name" value="SWIM-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31569:SF4">
        <property type="entry name" value="SWIM-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21056">
        <property type="entry name" value="ZSWIM1-3_RNaseH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21599">
        <property type="entry name" value="ZSWIM3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="6">
        <location>
            <begin position="497"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="5">
        <location>
            <begin position="856"/>
            <end position="904"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0804432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="904" mass="103823" checksum="E2B30749F97007A2" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B5P9</accession>
    <name>A0A5N4B5P9_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_01899</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B5P9"/>
    <dbReference type="InParanoid" id="A0A5N4B5P9"/>
    <dbReference type="OrthoDB" id="6119141at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0804929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="165" mass="18640" checksum="69EF6A4FD9D10746" modified="2020-02-26" version="1">MEDSGIDSGDHNGDSVPKPIQNNERLLATSDSSSADSSRSPSRTVPPSSTRTLQRKLESRIEHARRLHQEYHTTPGLIPIQRLPIPGARDHQPLVQWDTDDSEEDIVNFFPLSRKESRAHQELTDTFSIEEMSISGDEEEDLHLVPPQPVYRRFACCPFPICVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B600</accession>
    <name>A0A5N4B600_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Putative nuclease HARBI1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Harbinger transposase-derived nuclease</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PPYR_01948</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Transposase-derived protein that may have nuclease activity. Does not have transposase activity.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HARBI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B600"/>
    <dbReference type="InParanoid" id="A0A5N4B600"/>
    <dbReference type="OrthoDB" id="6757863at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026103">
        <property type="entry name" value="HARBI1_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF85">
        <property type="entry name" value="GH03217P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02086">
        <property type="entry name" value="PUTNUCHARBI1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="13">
        <location>
            <begin position="152"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAB0804978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="353" mass="41109" checksum="90FB6B9B885AD965" modified="2020-02-26" version="1">MEIILEEERIQEMRNFNIERRIARNNSDPFTLSDRHFVRCFRLTKHMVHYILERISPHMSHSAHINAVNPELRLFAALYFFGHGAYQKVVGHNFMLSMAQNTVSNCIQEISHLIVHYLSDEWIQFPTTEEEKLAIKVKFRETTHFPGVIGAVDCTHVAIIAPREEEHNFINRKGYHSKNIQIICDYNLKILNINPQFAGATHDAYIWRNSEVHQELERCYLAGDRHSWLLGDSGYPQQPWLMTPVLNALAGSAEERYNTHHASARNCIERCNGVFKQRFRCVLGERTLRYSPEKVGNIVVACAVLHNICTDARLELDVENMERIIPNEVNVNVQQMNENGRDARRILIENYFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B6C8</accession>
    <name>A0A5N4B6C8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DDE-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_01880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B6C8"/>
    <dbReference type="InParanoid" id="A0A5N4B6C8"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF74">
        <property type="entry name" value="POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE-1" evidence="1">
        <location>
            <begin position="67"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0804910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="255" mass="28833" checksum="0429BA1854A82427" modified="2020-02-26" version="1">MCRSEVNAFFDLLEKTLLEHNLINSGNKIFNMDESGIQLNNKPRKVIATKGSKDVHVLTSVEKGEHVTLIACNNGEGVFMPPVLILKGTRKNPDFMEGLPTGSEIYMNKKSSYITSELFMKWLTEHFVPRKGEGKVVLILDGHTSHTTNPEMLNYAEANDIIIICLPSHITQALQPLDRSFFKPMKDYFKKEADSWMLQNENRKNDRRNMGALIGRAWKNAATPANGMSGFEATSICPFNRTRIPDPFFPNQTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B7E0</accession>
    <name>A0A5N4B7E0_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_02489</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0805519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B7E0"/>
    <dbReference type="InParanoid" id="A0A5N4B7E0"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23992">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.20">
        <property type="entry name" value="Pheromone/general odorant binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006170">
        <property type="entry name" value="PBP/GOBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036728">
        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01395">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00708">
        <property type="entry name" value="PhBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0805519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="122" mass="14202" checksum="7E8D3212C5DAC9E9" modified="2020-02-26" version="1">MCRGSYLHENLRDEIRRAWEEEDAPFLDECAKETNVDPQIPKKMYKDLHFPNEESFHCYVWCLYNRQNALTPDGKDIEVEVLAMHPYVGLELAQRCVEEAKNETDICLKTYVATVCAIGHHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1JVX8</accession>
    <name>A0A1Y1JVX8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Putative nuclease HARBI1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Harbinger transposase-derived nuclease</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PPYR_00025</name>
        <name evidence="15" type="ORF">PPYR_15186</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">1611_PpyrPB1</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">1611_PpyrPB1</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Transposase-derived protein that may have nuclease activity. Does not have transposase activity.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HARBI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01099612">
        <property type="protein sequence ID" value="JAV53250.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01099606">
        <property type="protein sequence ID" value="JAV53263.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000741">
        <property type="protein sequence ID" value="KAB0790811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1JVX8"/>
    <dbReference type="InParanoid" id="A0A1Y1JVX8"/>
    <dbReference type="OrthoDB" id="6759714at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026103">
        <property type="entry name" value="HARBI1_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF85">
        <property type="entry name" value="GH03217P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02086">
        <property type="entry name" value="PUTNUCHARBI1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="13">
        <location>
            <begin position="178"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="JAV53263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAB0790811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAB0803055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="387" mass="43727" checksum="5CB0E267149A8A00" modified="2017-08-30" version="1">MKMDTNVLKIVVINNLLEIIDDSSSSDEELFAITANTRYKRKEATPRIENYVENVVHLYGDSQFQSHFRMQRRTFEVILELIADKIRERTVKPGRPAIPAEKQLLITLWVLGTPDSYRSVCDRFGVGKATAIVCVRNVVRILYNYSHSFIMWPTTEKITASVAAFKNMSGFPGVIGAIDGTHISITAPKEHPEAYVNRKGIHSIQLQGVCDEKGMFIHCYAGYPGAVHDQRVFMKSEVAEYLKSAAKFPGDVHLLGDAAYMLHTHMMVPYKDNGHLTRAQKNYNYCHSSTRMVIERSFGLLKGRMRRLLDNLPMIRTDLIPQYIIACCVIHNICLLKNDQFQPLALHTSDKNNTQCGVNGNVDTNEKALAKQKRDAIAAALPTREDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1JZJ8</accession>
    <name>A0A1Y1JZJ8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="6">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_01507</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="GEZM01098886">
        <property type="protein sequence ID" value="JAV53681.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KAB0804537.1"/>
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        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
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        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142:SF1">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="COesterase"/>
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    </dbReference>
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        <property type="entry name" value="alpha/beta-Hydrolases"/>
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        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
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    </dbReference>
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        <location>
            <begin position="1"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="JAV53681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0804537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="432" mass="48706" checksum="C8D8F97285B86CD5" modified="2017-08-30" version="1">MCWVPGGGFVSGSGNADLYGPEYLVTEDVVLVTFNYRVGLLGFLNFSDPSLDVPGNAGLKDQIMALKWIQENIANFGGDPHNVTIFGESAGGASVHLLILSPLAKGLFHKAIMQSGVATAGWSRGQATLPILKNVLSVQATEKQYLEILQQMSFDDIIQLQMKIPNALQPSFFRPFGPVIENVPSNTAFLTKEPLEIMRAGTYNQVPIIMGYTSREGMVVNYFNDHFYNYVADRVPVDFELEIPFIWNVPKGSSLSMKLAEEIKSFYFGSEKPSQKNRNRYYQLQGDSHFTWPLHFTLSHFIDSHSSTIYIYRMSVDTELNLMKKVSEEPGPGVCHADDLGYLFMNPATLPPPEHSTEMKTVKRFIKLWANFARTGNPNSKVTDSLISVLWKPVEKDRVHFLEIGENLTVGVNPDEDRIAFWWKLFRFAQRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1K7F2</accession>
    <name>A0A1Y1K7F2_PHOPY</name>
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    </protein>
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    <organism evidence="5">
        <name type="scientific">Photinus pyralis</name>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
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            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
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    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01090254">
        <property type="protein sequence ID" value="JAV57313.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000009">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="10253736at2759"/>
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    </dbReference>
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        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="17beta-HSDXI-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Short-chain dehydrogenase/reductase family 16C member 6"/>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
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    </dbReference>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
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    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
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        <property type="entry name" value="FI23927P1-RELATED"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="JAV57313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0794154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="341" mass="37903" checksum="EE26FD4D9B6E0CA4" modified="2017-08-30" version="1">MEMTKMEFNVLKSIMDLVSFFLVSTVLVIKAIIYGCLPKSYKKKKNFENEIVLITGGAGGIGRLVALKLAKLNAKIVLWDVDTSGIEDAVNQVRGIGGKAYGYKCDLTDREDVYRTANKVYEEVGQVTILINNAGIASGRLLLDTPDHLIQRTFDVNIISHFWTTKAFLPKMIDSNHGHIVTIASLAGHIGVHKLVDYCSSKFAAVGFDESLRIELEKLGVTGVKTTVVCPYFIQATGMFNDVVSRFVPTLKSTQVADEIVEAIELEKLSVIIPRYLGILCVKWILPWTVISLFMRNIVSNAGPTHAEALPHENKKMPEKGMFQTNAESELHHRAHVTEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1KA77</accession>
    <name>A0A1Y1KA77_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NAC-A/B domain-containing protein</fullName>
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    <gene>
        <name evidence="4" type="ORF">PPYR_00887</name>
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    <organism evidence="3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
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            <taxon>Pterygota</taxon>
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            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
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            <taxon>Photinus</taxon>
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    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
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                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01087975">
        <property type="protein sequence ID" value="JAV58363.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1KA77"/>
    <dbReference type="FunCoup" id="A0A1Y1KA77">
        <property type="interactions" value="1215"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1KA77"/>
    <dbReference type="OrthoDB" id="3169036at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005854">
        <property type="term" value="C:nascent polypeptide-associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22054">
        <property type="entry name" value="NAC_NACA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14358">
        <property type="entry name" value="UBA_NAC_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.30:FF:000002">
        <property type="entry name" value="Nascent polypeptide-associated complex (NAC), alpha subunit"/>
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    </dbReference>
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            <begin position="1"/>
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    </feature>
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            <begin position="26"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="176"/>
        </location>
    </feature>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="JAV58363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0803917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="216" mass="22886" checksum="7E37CC4770222E8B" modified="2017-08-30" version="1">MPELTEIEKATVAEAKSDHSHSSTDSDTDDEIPELEDAGAGGAAGTGAFPGAAAAAGLPIDMVSKAKQSRGEKKARKIMSKLGLKQVQGVNRVTIRKSKNILFVINKPDVYKNPVSDTYIVFGEAKIEDLSQQAQVAAAEKFKEVNPAGDGASGNPTTSVAPIAEESEDEEVDETGVEDKDVELVMTQANVSRSKAIKALKNNQNDIVNAIMELTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1KC24</accession>
    <name>A0A1Y1KC24_PHOPY</name>
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            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
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    <gene>
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        <name evidence="12" type="ORF">PPYR_12082</name>
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        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
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            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="11">1611_PpyrPB1</strain>
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        </source>
    </reference>
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        <subcellularLocation>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-0813">Transport</keyword>
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        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <end position="130"/>
        </location>
    </feature>
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        </location>
    </feature>
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            <end position="188"/>
        </location>
    </feature>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="KAB0795210.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAB0795243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="476" mass="52669" checksum="D41D681F671E3979" modified="2017-08-30" version="1">MIVKPFKTYKRTQFLAAYTATISAISDGMQYSWAAPIIPILQSADSKIKITETDVMWLQNMYSVGGGIGLITAIFTVKRFGCKISILMSAVLSLLAWMMIALMVSVECLYVARFFCGVASEMVYVSAPMYVGEISDKEVRGFLSSLLPMNLIFGIIVMFCIGPFVPIYISSAVGSIPIIIQLICFSFMPDSPYYSLSKNKVETATKNLQKLRQTDDVDAELEQISSNIAKEQADGGRVIDLFLLKGCRKALLILAVINCSVHFCGFTAVVMNIHSILESAGSPVAPSAAAIIFSSLMLASIIFTSPLIDRAGRKMMLILSSVITTLLLFVFASYFTIQLYIPAVTEYNWIPLISMMIYGMAYRCGFGTVSVVLTAELFPSNVKVIGITISDALYVIFSFLSIYIYQTFRVSYGIHVPFFIFGFWCIFSIAFILFYLPETKGKSLEEIQKILKGNVPNTKSAEIHLEALKGKETTNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1KFX7</accession>
    <name>A0A1Y1KFX7_PHOPY</name>
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        <recommendedName>
            <fullName evidence="2">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="4" type="ORF">PPYR_08637</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Photinus pyralis</name>
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        <lineage>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
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            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
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                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01084914">
        <property type="protein sequence ID" value="JAV60409.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01084912">
        <property type="protein sequence ID" value="JAV60413.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1KFX7"/>
    <dbReference type="FunCoup" id="A0A1Y1KFX7">
        <property type="interactions" value="982"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5596422at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23814">
        <property type="entry name" value="UEV_AKTIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000121">
        <property type="entry name" value="Protein crossbronx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
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                <person name="Debat H.J."/>
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                <person name="Day J.C."/>
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                <person name="Schmitz R.J."/>
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                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
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                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
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        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
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        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
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                <person name="Bessho-Uehara M."/>
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                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
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                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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                <person name="Bessho-Uehara M."/>
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                <person name="Debat H.J."/>
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                <person name="Shigenobu S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016648"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF26091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="JAV64007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0798621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="208" mass="24205" checksum="326EB11C7AE8C67D" modified="2017-08-30" version="1">MATAVDEFGLWLGKKLRDLDIDECVFGSYISGILDGDESEEEKTDALEGILSEILVTDNDIIKIRSEIMEMWSQLRQPQMSATTQAVSSEEVDIRLARLLESQSLQIPKQKQYTDEEKKIREAILSQYSQMTDDEDDDVNEPGDVKENGLEKNRNAHAVMQAEKEKREQAKLESQKKKEKDKEDREKQKQLREEKKEKRKTQKGERRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1L2R4</accession>
    <name>A0A1Y1L2R4_PHOPY</name>
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        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="8" type="ORF">PPYR_01680</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
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            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
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            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
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    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
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                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GEZM01068241">
        <property type="protein sequence ID" value="JAV67068.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KAB0804710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS"/>
    </dbReference>
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        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="GH23453P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036029787" description="Major facilitator superfamily (MFS) profile domain-containing protein" evidence="6">
        <location>
            <begin position="20"/>
            <end position="459"/>
        </location>
    </feature>
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        <location>
            <begin position="100"/>
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        </location>
    </feature>
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    </feature>
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        </location>
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    </feature>
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        <location>
            <begin position="416"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAB0804710.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="459" mass="51003" checksum="EA2AC48269E82C22" modified="2017-08-30" version="1">MKLSVDIPFALLLFAFALSDPVTTNFVVYRTCYVTMGFNKSDCALLGTPEATDETAKLELKVQPHAAVLTTTKSVTEIVVTSIWCFFLGPWSDQYGRRPVMIMSLAGFVCAYAIITAISLFEMLSPWFLLLASIPICLTGGFPSFLAVSICHLTETTHIVKRGFRMGIFEAVITIAGLLGATASSFVFHAYGYFTLYYITASCIVTAWIIVMIFVQESNPNPETEGRCRNLFKFSLIKDTVKTTFEERPGLDRPLLLSVILMTVIFLLAVTADGNIVFLYLRRKLSWTLRQYTLFASCRKISWIIGSILGGYVLHTLLKVEESVVILLGFLSVMANVLIQGLASKDWHMYVAGAVICFGGSISPMTRSLISKLVHFNECGKVFSFVIMVETIVDLLGSPIYTYIYNHTIETLPGAFNFVTTGIYGFEVVLTIGIITLQLRRFGNDNYEPINDVIDVVNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LBW5</accession>
    <name>A0A1Y1LBW5_PHOPY</name>
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        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
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    </protein>
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    </gene>
    <organism evidence="6">
        <name type="scientific">Photinus pyralis</name>
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        <lineage>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
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            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
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            <taxon>Elateroidea</taxon>
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            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GEZM01060249">
        <property type="protein sequence ID" value="JAV71162.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    </dbReference>
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        <property type="entry name" value="PMP22/EMP/MP20/Claudin"/>
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        <property type="entry name" value="LD36024P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21215:SF0">
        <property type="entry name" value="LD36024P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13903">
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    </dbReference>
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        <location>
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            <begin position="155"/>
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        <location>
            <begin position="213"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="JAV71162.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAB0793974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="292" mass="33222" checksum="F90C6E131BD06C7A" modified="2017-08-30" version="1">MPCSAVTLSLATITSIIAVALLAIAFATDNWLYIEVKRSNIQSLFNNQRDSALVDSLNSKYYYYTRTKGLFRICYPKERPPTVKTYLSPVETHCNNINYFIPDDNNETKDFSEDAWNKLHMARSVIALFILTFITIFATFCTGVTGCWRRSPCNITATAVLMLLACLLSAGAMGLWHGVEYYEKEKVVGEEFYQQWNNVLRENTRINYDWSYMLAWVGVIWSLVAAILFSGAAICLRGEREREEAINMQYLMPVYPQKQQYAYAGYAVPPPQSYAGPCPYYTAGSGYGSYNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LQ52</accession>
    <name>A0A1Y1LQ52_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Coactosin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PPYR_01773</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Binds to F-actin in a calcium-independent manner. Has no direct effect on actin depolymerization. Acts as a chaperone for ALOX5 (5LO), influencing both its stability and activity in leukotrienes synthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Interacts with 5-lipoxygenase (ALOX5/5LO) in a calcium-independent manner. Binds to F-actin with a stoichiometry of 1:2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the actin-binding proteins ADF family. Coactosin subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01049837">
        <property type="protein sequence ID" value="JAV75814.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1LQ52"/>
    <dbReference type="FunCoup" id="A0A1Y1LQ52">
        <property type="interactions" value="526"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1LQ52"/>
    <dbReference type="OrthoDB" id="20822at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11282">
        <property type="entry name" value="ADF_coactosin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000018">
        <property type="entry name" value="Coactosin-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10829:SF29">
        <property type="entry name" value="COACTOSIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10829">
        <property type="entry name" value="CORTACTIN AND DREBRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADF-H" evidence="9">
        <location>
            <begin position="25"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00058385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00062335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00068121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="JAV75814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0804803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="167" mass="18764" checksum="FCBDB8A1AE17AA9F" modified="2017-08-30" version="1">MSVETVEGTEYDQIVLNGPKKVAMATSLDADAIREAYADVRSDTSETQWAVFKFDGQRIVCFAKGDEFDKFKEHFGENERAFGYIRVQTGDEMSKRQKFLFVTWVGPSVSVIQRAKMSTDKSMIKDIIKNFAVELQLEALSECDLSYFKEALNKAGGANYGTGVRDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LVH0</accession>
    <name>A0A1Y1LVH0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">U4/U6 small nuclear ribonucleoprotein Prp31</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Pre-mRNA-processing factor 31</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PPYR_12436</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">1611_PpyrPB1</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">1611_PpyrPB1</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Involved in pre-mRNA splicing as component of the spliceosome. Required for the assembly of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PRP31 family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01047337">
        <property type="protein sequence ID" value="JAV76878.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0795597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1LVH0"/>
    <dbReference type="FunCoup" id="A0A1Y1LVH0">
        <property type="interactions" value="2049"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1LVH0"/>
    <dbReference type="OrthoDB" id="4771285at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.90:FF:000002">
        <property type="entry name" value="U4/U6 small nuclear ribonucleoprotein Prp31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.4070:FF:000003">
        <property type="entry name" value="U4/U6 small nuclear ribonucleoprotein PRP31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.90">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042239">
        <property type="entry name" value="Nop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002687">
        <property type="entry name" value="Nop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036070">
        <property type="entry name" value="Nop_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012976">
        <property type="entry name" value="NOSIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027105">
        <property type="entry name" value="Prp31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019175">
        <property type="entry name" value="Prp31_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13904">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR PRP31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13904:SF0">
        <property type="entry name" value="U4_U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01798">
        <property type="entry name" value="Nop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09785">
        <property type="entry name" value="Prp31_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00931">
        <property type="entry name" value="NOSIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89124">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51358">
        <property type="entry name" value="NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Nop" evidence="13">
        <location>
            <begin position="219"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="339"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="339"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="355"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="JAV76878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAB0795597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="494" mass="55195" checksum="C13AC5C91F147969" modified="2017-08-30" version="1">MSLADELLADLEENDQDEFEEGMDAEDASEVKEEKPKIIIPMEEDTTKINSVKELCKLWNSDQLRTIMKQIKSYGSKPRKASDIIGPVESDPEYQLIVEANNMAADIDGEIVTVHKFVREKYQKRFPELDSLVVSPLEYVRTVKELGNDLDQAKNNEILQQYLTQATIMVVSVTASTTQGTLLTEFEKFQIDEACDIAIELNNCKLEIYEYVESRMAFIAPNISAIIGASTAAKIMGIAGGLTRLSKIPACNVLILGEQKKSLSGFSQTNMLPHTGFVYYSEIVQNSPPDLRRKAARLVAAKSILAARVDSCHESTDGRIGKMLREEIEKKLDKLQEPPPVKFVKPLPKPVEAPRKKRGGKRVRKMKERYAMTEFRKHANRMNFADIEDDAYQEDLGYTRGTIGKSGAGRIRLPQVDEKTKVRISKTLQKNLQKQHAWGGSTTVKKQVSGTASSVAFTPLQGLEIVNPQAAEVKVNEANAKYFSNTSGFVKLDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LWJ0</accession>
    <name>A0A1Y1LWJ0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Spaetzle domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PPYR_12350</name>
        <name evidence="7" type="ORF">PPYR_13575</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01045136">
        <property type="protein sequence ID" value="JAV77903.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0795511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1LWJ0"/>
    <dbReference type="FunCoup" id="A0A1Y1LWJ0">
        <property type="interactions" value="74"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1LWJ0"/>
    <dbReference type="OrthoDB" id="6359065at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005121">
        <property type="term" value="F:Toll binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021556">
        <property type="term" value="P:central nervous system formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.90.10:FF:000056">
        <property type="entry name" value="Protein spaetzle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032104">
        <property type="entry name" value="Spaetzle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052444">
        <property type="entry name" value="Spz/Toll_ligand-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23199">
        <property type="entry name" value="NEUROTROPHIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23199:SF12">
        <property type="entry name" value="NEUROTROPHIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16077">
        <property type="entry name" value="Spaetzle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033289894" description="Spaetzle domain-containing protein" evidence="4">
        <location>
            <begin position="21"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Spaetzle" evidence="5">
        <location>
            <begin position="146"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="JAV77903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0793955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0795511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="257" mass="28508" checksum="15C483BAFC2861C1" modified="2017-08-30" version="1">MLSSVFVSLSVFTVIRLKIGETASLSQPCSAIISKKRADNLEGDESLLLNITPNFTLSEPTQPVLTNQTKRHSAIVFPDSTEDLADIIFPVDVSQCGTASTVCEDVTSYPYEHIKFVLNKRNDAKGFFGVDEGAIEHRIGEPDDNFICASLEKTIFPKAGKNKYSKWKYIINQGDNDGYVQGVRIETCVKLNGPCNLLGSAPYGFITSCKQKYIYRRLLSVSDSGMPIADTFQIPSACCCSYRRNNDYLLNFGRKIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LWN0</accession>
    <name>A0A1Y1LWN0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Aurora kinase</fullName>
            <ecNumber evidence="14">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PPYR_10869</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">1611_PpyrPB1</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">1611_PpyrPB1</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Midbody</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="14"/>
    <dbReference type="EMBL" id="GEZM01045063">
        <property type="protein sequence ID" value="JAV77943.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1LWN0"/>
    <dbReference type="FunCoup" id="A0A1Y1LWN0">
        <property type="interactions" value="468"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1LWN0"/>
    <dbReference type="OrthoDB" id="377346at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030261">
        <property type="term" value="P:chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032506">
        <property type="term" value="P:cytokinetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14007">
        <property type="entry name" value="STKc_Aurora"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000235">
        <property type="entry name" value="Serine/threonine-protein kinase ark1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030616">
        <property type="entry name" value="Aur-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24350">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE IAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
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</entry>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
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        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
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                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
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            <dbReference type="PubMed" id="30324905"/>
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    </evidence>
    <sequence length="688" mass="78883" checksum="A97EE4458F5FDD56" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
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                <person name="Bessho-Uehara M."/>
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                <person name="Debat H.J."/>
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                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
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                <person name="Schmitz R.J."/>
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                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
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                <person name="Oba Y."/>
                <person name="Weng J.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </reference>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
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            <end position="327"/>
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        <location>
            <begin position="379"/>
            <end position="601"/>
        </location>
    </feature>
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        </source>
    </evidence>
    <sequence length="211" mass="23284" checksum="CCD3BDF8866841FA" modified="2017-08-30" version="1">MKSVIVIIAISVLTQRAHAWGGLFNRFSPEMLANMGYGGHSGFIQRAGDEGILEEFETDSDDDPCYGRRCTANEHCCPGLVCVDVDGAGTCLFAYGRRAGELCRRDSDCESGLLCTESESGGATRICRPPVRQDKQYSETCNMSSECDISRGLCCQLQRRHRQAPRKVCSYFKDPLVCIGPVASDQIKNSIQHTAGEKRLTGFTAYKRPMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1MFP2</accession>
    <name>A0A1Y1MFP2_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PPYR_14090</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">1611_PpyrPB1</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">1611_PpyrPB1</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SINA (Seven in absentia) family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="GEZM01032377">
        <property type="protein sequence ID" value="JAV84622.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1MFP2"/>
    <dbReference type="InParanoid" id="A0A1Y1MFP2"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000041">
        <property type="entry name" value="E3 ubiquitin-protein ligase SINAT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004162">
        <property type="entry name" value="SINA-like_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049548">
        <property type="entry name" value="Sina-like_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013010">
        <property type="entry name" value="Znf_SIAH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45877">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SIAH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45877:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SINA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21362">
        <property type="entry name" value="Sina_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21361">
        <property type="entry name" value="Sina_ZnF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51081">
        <property type="entry name" value="ZF_SIAH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SIAH-type" evidence="13">
        <location>
            <begin position="66"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="341"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="SIAH-type" evidence="13">
        <location>
            <begin position="393"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="264"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="JAV84622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAB0792129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="580" mass="65704" checksum="9C8DB1F0F466EE9C" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1MK09</accession>
    <name>A0A1Y1MK09_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SGNH hydrolase-type esterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_03370</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDSL' lipolytic enzyme family. Platelet-activating factor acetylhydrolase IB beta/gamma subunits subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01033647">
        <property type="protein sequence ID" value="JAV84206.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1MK09"/>
    <dbReference type="InParanoid" id="A0A1Y1MK09"/>
    <dbReference type="OrthoDB" id="505607at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01820">
        <property type="entry name" value="PAF_acetylesterase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11852">
        <property type="entry name" value="PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11852:SF0">
        <property type="entry name" value="PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE IB SUBUNIT BETA HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH hydrolase-type esterase" evidence="2">
        <location>
            <begin position="61"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="JAV84206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0791570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="242" mass="27073" checksum="2FA6F40E3F514ABA" modified="2017-08-30" version="1">MTGTQNGAQTMVSEFQGMSLKSANICTVPQRKHDIFGDNRWETMHERYVSEARNSEADVVFVGDSIVQQLQLTTLWNEKINPLHCLNFGIGGDRVENVLWRLLNGELEFACTPKVVVLFVGTNNTDCTAQQVYEGICHLIDVISTKLGDVKIVLPTLLPRGQHPSANRERNMLVNELCMNNFDSVSVNPNVHVVPIHEDIVQGDGTISHHLMHDYLHLTDEGYSKVFGPVYEKLAALMSNTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1MKT5</accession>
    <name>A0A1Y1MKT5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_02683</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01028378">
        <property type="protein sequence ID" value="JAV86333.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0805713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1MKT5"/>
    <dbReference type="FunCoup" id="A0A1Y1MKT5">
        <property type="interactions" value="1929"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1MKT5"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03752">
        <property type="entry name" value="proteasome_alpha_type_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000022">
        <property type="entry name" value="Proteasome subunit alpha type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003075">
        <property type="entry name" value="PRK03996.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 5 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="7">
        <location>
            <begin position="5"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="JAV86333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0805713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="258" mass="28782" checksum="2FE59FE7306FDC00" modified="2017-08-30" version="1">MARRYDTRTTIFSPEGRLYQVEYAMEAISHAGTCLGILATDGILLAAERRNTNKLLDEVFSSEKIYKLNDDMVCSVAGITSDANVLTNELRLIGQRYLIQYGESIPCEQLVSWLCDVKQAYTQYGGKRPFGVSILYMGWDKHYGYQLYQSDPSGNYSGWKATCIGNNSAAAVSSLKQEYKEGEMTLKDAKALAIKVLSKTLDMTKLTSEKVEMATLTRSDNKTDTHILSSKEVEALISDFEKSEAAAEALKKEQKQKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1MM15</accession>
    <name>A0A1Y1MM15_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">F-ATPase delta subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PPYR_09353</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">1611_PpyrPB1</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">1611_PpyrPB1</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase epsilon chain family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01027480">
        <property type="protein sequence ID" value="JAV86723.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1MM15"/>
    <dbReference type="FunCoup" id="A0A1Y1MM15">
        <property type="interactions" value="1350"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1MM15"/>
    <dbReference type="OrthoDB" id="270171at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12152">
        <property type="entry name" value="F1-ATPase_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.15.10:FF:000004">
        <property type="entry name" value="ATP synthase subunit delta, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.440">
        <property type="entry name" value="ATP synthase delta/epsilon subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.15.10">
        <property type="entry name" value="F0F1 ATP synthase delta/epsilon subunit, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00530">
        <property type="entry name" value="ATP_synth_epsil_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001469">
        <property type="entry name" value="ATP_synth_F1_dsu/esu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020546">
        <property type="entry name" value="ATP_synth_F1_dsu/esu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048937">
        <property type="entry name" value="ATPD_C_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036771">
        <property type="entry name" value="ATPsynth_dsu/esu_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01216">
        <property type="entry name" value="ATP_synt_epsi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13822">
        <property type="entry name" value="ATP SYNTHASE DELTA/EPSILON CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13822:SF7">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT DELTA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02823">
        <property type="entry name" value="ATP-synt_DE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21335">
        <property type="entry name" value="ATPD_C_metazoa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51344">
        <property type="entry name" value="Epsilon subunit of F1F0-ATP synthase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="10" id="KW-0139">CF(1)</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATP synthase F1 complex delta/epsilon subunit N-terminal" evidence="14">
        <location>
            <begin position="34"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="F1F0-ATP synthase delta subunit C-terminal" evidence="15">
        <location>
            <begin position="115"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="117"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF21335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="JAV86723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAB0798360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="158" mass="16737" checksum="6F1AA35D594C4739" modified="2017-08-30" version="1">MAAVRSISRLLSQRSVSQIVRRGYADEMSFTFAAGNQVFYESASVRQVDVPSFSGAFGILPKHVPTLAVLKPGVITVTENDGSIKKVFVSSGTVTINEDSSVQVIAEEAATLDQLDLAAAKETLSSALSQMNSAQSEKEKAEAAIAVEVAETIVKSIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1N2T4</accession>
    <name>A0A1Y1N2T4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Guanine nucleotide-binding protein subunit alpha homolog</fullName>
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        <name evidence="17" type="ORF">PPYR_12091</name>
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        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
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            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
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            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
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        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">1611_PpyrPB1</strain>
            <tissue evidence="17">Whole body</tissue>
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    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">1611_PpyrPB1</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
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        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the G-alpha family. G(12) subfamily.</text>
    </comment>
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        <property type="molecule type" value="Transcribed_RNA"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA HOMOLOG"/>
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    </dbReference>
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        <property type="entry name" value="G-alpha"/>
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    </dbReference>
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        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00440">
        <property type="entry name" value="GPROTEINA12"/>
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        <property type="entry name" value="G_alpha"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="9 14" id="KW-0342">GTP-binding</keyword>
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    <keyword evidence="6 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0564">Palmitate</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0807">Transducer</keyword>
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        <location>
            <begin position="50"/>
            <end position="55"/>
        </location>
        <ligand>
            <name>GTP</name>
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    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
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            <end position="159"/>
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        <ligand>
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        <ligand>
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    <sequence length="364" mass="42948" checksum="953BD235EB545E93" modified="2017-08-30" version="1">MWSCPCCLRFRFSPEELEQRYKSQEIDKMLEKDKQALKRQVKLLLLGAGESGKSTFLKQMRIIHGIKFEYELVKEYQQDIYQNVIRGMKVLVDARDKLGIPWEETNNNDSGRKLLEYSNSITLDSRTFMNYAPFVGRLWKDSGIRRAFDRRREFQLSDSVEYFFNHLDRICRIDYIPTHQDILHCRKATKGITEFIIPINKVPFLFVDVGGQRSQRQKWFQCFDSVTSILFLVSSSEFDQVLLEDRKTNRLEESKDIFDTIINNRVFGNVSIILFLNKYDLLVKKVANPETDIRWYFPQFAGNSHSIQDVQAFILAMFTSVKREPRKALYHHYTTAVDTENIKVVFNSVKDTILNRNLEILMLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
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        <recommendedName>
            <fullName evidence="10">c-Myc-binding protein</fullName>
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        <name evidence="6" type="ORF">PPYR_11576</name>
    </gene>
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        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
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            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
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                <person name="Al-Wathiqui N."/>
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            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6 9" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
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                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
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            <dbReference type="PubMed" id="30324905"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
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        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
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                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
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        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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        </subcellularLocation>
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        <text evidence="2">Belongs to the AMY1 family.</text>
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        <property type="term" value="C:nucleus"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="AMY1"/>
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        <property type="entry name" value="ASSOCIATE OF C-MYC AMY-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13168:SF0">
        <property type="entry name" value="C-MYC-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02028">
        <property type="entry name" value="CMYCBINDINGP"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="94"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="JAV97463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0794737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0801821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0801954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="105" mass="11766" checksum="07C71F73C4EE1BD2" modified="2017-08-30" version="1">MTANPNYKPSESKREEFRKYLEKTGVMDALTKVLVSLYEEPDKPDNAVEYICNKLSNQICGETLTDIRANLQEALTKISDLEKENAAMKVEPEGPSEEADDVPAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1NK10</accession>
    <name>A0A1Y1NK10_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_12398</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the RNase T2 family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01002450">
        <property type="protein sequence ID" value="JAV97250.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0795559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1NK10"/>
    <dbReference type="FunCoup" id="A0A1Y1NK10">
        <property type="interactions" value="95"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1NK10"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033897">
        <property type="term" value="F:ribonuclease T2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Ribonuclease T2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNase_T2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036430">
        <property type="entry name" value="RNase_T2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033130">
        <property type="entry name" value="RNase_T2_His_AS_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11240">
        <property type="entry name" value="RIBONUCLEASE T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11240:SF22">
        <property type="entry name" value="RIBONUCLEASE T2"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00445">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55895">
        <property type="entry name" value="Ribonuclease Rh-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00531">
        <property type="entry name" value="RNASE_T2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="JAV97250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0795559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="244" mass="28194" checksum="8BAAB972292C2265" modified="2017-08-30" version="1">MQVNANNSCFLPTDGNIWTVHGIWPTKSGTRGPWNCNTNRFNESLIKEIESDLKQRWVNIENNTKPLSFWEHEWQKHGTCAQVLPVLNTELKYFSKGLEWNHMFNIHKLLLSSSIIPSLSGYTIEKIYSSIRNVLNHNPIMQCVIDKHTKESLLSEIQLCFDRALNMMDCDSVKELFDQVVKVGSVLTDCSLKKVVVYPSNVLPTHPPDVVRSDVRATIDDLLENRNYWITIYKTVKFLIWATI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1NKZ4</accession>
    <name>A0A1Y1NKZ4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PPYR_11494</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">1611_PpyrPB1</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">1611_PpyrPB1</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the syntaxin family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01001577">
        <property type="protein sequence ID" value="JAV97660.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01001576">
        <property type="protein sequence ID" value="JAV97662.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0794655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1NKZ4"/>
    <dbReference type="FunCoup" id="A0A1Y1NKZ4">
        <property type="interactions" value="333"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1NKZ4"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006836">
        <property type="term" value="P:neurotransmitter transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00179">
        <property type="entry name" value="SynN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.70:FF:000042">
        <property type="entry name" value="Syntaxin 11b, tandem duplicate 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000022">
        <property type="entry name" value="Syntaxin 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006012">
        <property type="entry name" value="Syntaxin/epimorphin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006011">
        <property type="entry name" value="Syntaxin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF424">
        <property type="entry name" value="SYNTAXIN-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00804">
        <property type="entry name" value="Syntaxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00503">
        <property type="entry name" value="SynN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00914">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0532">Neurotransmitter transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="13">
        <location>
            <begin position="197"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="35"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="JAV97660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAB0794655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="293" mass="33328" checksum="EC83546A0FF13E35" modified="2017-08-30" version="1">MTKDRLAALVAAQSDDDDVGPDDVSVNVEGRDGFMDAFFAEVEEIREMIDKIQANVEEVKKKHSAILSAPQSDEKTKQELEDLMADIKKTANKVRAKLKVIEQSIEQEEQTNKSSADLRIRKTQHSTLSRKFVEVMTEYNRTQTDYRERCKGRIQRQLEITGRQTTNEELEEMLEQGNPAVFTQGIIMETQQAKQTLADIEARHADIIKLENSIRELHDMFMDMAMLVENQGEMVDRVEYHVSQTTTAVQAGRVEMKKAQAYQSKARQKKILIIICLIVAIVILVIILGFALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2023-09-13" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1NL31</accession>
    <name>A0A1Y1NL31_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_01104</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01004143">
        <property type="protein sequence ID" value="JAV96457.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1NL31"/>
    <dbReference type="InParanoid" id="A0A1Y1NL31"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="JAV96457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0804134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="162" mass="19361" checksum="D6C9EEAF3028A1B6" modified="2017-08-30" version="1">MSESSESSASSSDEDSYDLFELQDDLIYKETQRRKELKKLPVIPRCKLKKAIKRLKEDPKKKYDKLSPIEKRAVHMKKTCTNNKKVQDRILWGSPTYLMRAIKNCILTRNWNNLSLLLLLLLRHNRVYRGFVKQMTLWNFMCNPDDYDNQYFNDLVHLCKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-06-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N3ZZP7</accession>
    <name>A0A5N3ZZP7_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_15054</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01001133">
        <property type="protein sequence ID" value="KAB0790547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N3ZZP7"/>
    <dbReference type="InParanoid" id="A0A5N3ZZP7"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0790547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="64" mass="7059" checksum="DEBAE9F00704D015" modified="2020-02-26" version="1" fragment="single">KFGLYLIDVYHLKLTSNSRMETLKTADGKNQNVLGTVDLPITVDGITKVLRVIASNSIETNLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A012</accession>
    <name>A0A5N4A012_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_14897</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000942">
        <property type="protein sequence ID" value="KAB0790661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A012"/>
    <dbReference type="InParanoid" id="A0A5N4A012"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33480">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33480:SF1">
        <property type="entry name" value="TYR RECOMBINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="458"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="475"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0790661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="524" mass="59601" checksum="E54F52F90270E1A8" modified="2020-02-26" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-06-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A092</accession>
    <name>A0A5N4A092_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_03664</name>
        <name evidence="2" type="ORF">PPYR_15681</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000814">
        <property type="protein sequence ID" value="KAB0790732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A092"/>
    <dbReference type="InParanoid" id="A0A5N4A092"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="205"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0790732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0791864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="236" mass="27003" checksum="ADEA0F43E533F2F7" modified="2020-02-26" version="1">MEKKTPEQLRTKYDNLKKDARRYFAKQRQDIYRTGGGVIENVISDILKHIFEKIRAITTLSMEGIEPPVGDSDFCSLSTSETSNFEETSKSVAEAGDDDQHFTQPLDDKMQDVEGIEVVYVEPCVEESVASTPANDWSTYTPTMLRTKKHKLLREKKGDTTNKNALTSSKVLNEITNSKIELNKLKKDLLTQEIREKAELNKEILDTHKLKKENLRLQNELLSLQIKKLKETNSIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A0D4</accession>
    <name>A0A5N4A0D4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Odorant receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PPYR_15295</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cell membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000761">
        <property type="protein sequence ID" value="KAB0790785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A0D4"/>
    <dbReference type="FunCoup" id="A0A5N4A0D4">
        <property type="interactions" value="21"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A0D4"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="235"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU351113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0790785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="368" mass="42728" checksum="3586EEB3AA5D8BC0" modified="2020-02-26" version="1">MTATGAWPDHSSITYNIKALFFHAFTIGLFVTMSMQVIFNLNDFTNLSEILYIMVTVTGYVVKQCALTYKRNVFVNLIQFLKDPLFLSYPDELDHYMFETVKKSTLIANVYRFSIAFCIVLFTVYPILENKPLPFPFPYDLGNYRYFMYAFQIISVGVCAWNNCTIDTLTTSLMGIAAAQLDILYEKLIVIRKESQENDDVPYCEKSEEDILHKLRQCVEHHNAIIHLVESIEDIFTVGLLAQFTCSIIVICNTVFYIILMWTINSQFVMLLDYLIILMLQLFMYCWYGNEIILKSVKIGEACYKFNWCDSGTPVRQTLFIIMERSKRPLTITTVKLSTLSLSAYKSILQWSYSCLALLLKMEQQRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A2X2</accession>
    <name>A0A5N4A2X2_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4200 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_03475</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A2X2"/>
    <dbReference type="InParanoid" id="A0A5N4A2X2"/>
    <dbReference type="OrthoDB" id="10264298at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051147">
        <property type="entry name" value="CFAP_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025252">
        <property type="entry name" value="DUF4200"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21683:SF2">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 42 LIKE-2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21683">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 42 LIKE-2-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13863">
        <property type="entry name" value="DUF4200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4200" evidence="3">
        <location>
            <begin position="55"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="51"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="195"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0791675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="332" mass="39020" checksum="A241B199229C6AD1" modified="2020-02-26" version="1">MYYTELENELTFPQISPEKTIGDFLESKLNERVLKKYPEWDFPRVEPKIALAALQRDLDDSEQRLTEKREEAKSSKAQLDNEWKSLEEEGLKLRKTFCDFDKMIKENAEKTARATSKTKRLIISKANTDNAIKQTENDHNKLLKVKDEMEQQIRDHQIYESYLEVVSETNKGEFPTAQDVFNKFAILDEARNVVTKRLEHNIRALEETKDRMEQQLIDQSTVLIGLNNRVAALNDRFRAANAKCEKWEGVVRTAQVSLRDRLLDILSTRRVCWNLYLNMCRRRKTEPRIRKSDLEAQLWYIKRHLRLLGTTIRIADKMAADAEAVEKTKSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A325</accession>
    <name>A0A5N4A325_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PPYR_03517</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A325"/>
    <dbReference type="InParanoid" id="A0A5N4A325"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015439">
        <property type="term" value="F:ABC-type heme transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18581">
        <property type="entry name" value="ABC_6TM_ABCB6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03253">
        <property type="entry name" value="ABCC_ATM1_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000186">
        <property type="entry name" value="ATP-binding cassette sub-family B member 7, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221:SF654">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B MEMBER 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="295"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="59"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="383"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAB0791717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="631" mass="71508" checksum="15B0D1ABC24DE973" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A385</accession>
    <name>A0A5N4A385_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Clathrin heavy chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_03604</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasmic vesicle membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <location evidence="6">Coated pit</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the clathrin heavy chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A5N4A385">
        <property type="interactions" value="2282"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A385"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030132">
        <property type="term" value="C:clathrin coat of coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030130">
        <property type="term" value="C:clathrin coat of trans-Golgi network vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071439">
        <property type="term" value="C:clathrin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045334">
        <property type="term" value="C:clathrin-coated endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032051">
        <property type="term" value="F:clathrin light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045807">
        <property type="term" value="P:positive regulation of endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006898">
        <property type="term" value="P:receptor-mediated endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016050">
        <property type="term" value="P:vesicle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000001">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000002">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000007">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000009">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.110:FF:000001">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.110">
        <property type="entry name" value="Clathrin heavy-chain terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055358">
        <property type="entry name" value="CHCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015348">
        <property type="entry name" value="Clathrin_H-chain_linker_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016025">
        <property type="entry name" value="Clathrin_H-chain_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022365">
        <property type="entry name" value="Clathrin_H-chain_propeller_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016341">
        <property type="entry name" value="Clathrin_heavy_chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10292:SF1">
        <property type="entry name" value="CLATHRIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10292">
        <property type="entry name" value="CLATHRIN HEAVY CHAIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00637">
        <property type="entry name" value="Clathrin"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09268">
        <property type="entry name" value="Clathrin-link"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13838">
        <property type="entry name" value="Clathrin_H_link"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01394">
        <property type="entry name" value="Clathrin_propel"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002290">
        <property type="entry name" value="Clathrin_H_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00299">
        <property type="entry name" value="CLH"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50989">
        <property type="entry name" value="Clathrin heavy-chain terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0168">Coated pit</keyword>
    <keyword evidence="5 6" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="3 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Clathrin heavy chain linker core motif" evidence="8">
        <location>
            <begin position="338"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="544"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="693"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="840"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="986"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="1135"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="1281"/>
            <end position="1427"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="1430"/>
            <end position="1573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0791804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1612" mass="184263" checksum="28AEBEF340DB8935" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A3I8</accession>
    <name>A0A5N4A3I8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PPYR_03677</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A3I8"/>
    <dbReference type="InParanoid" id="A0A5N4A3I8"/>
    <dbReference type="OrthoDB" id="6743209at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000068">
        <property type="entry name" value="transmembrane protease serine 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050430">
        <property type="entry name" value="Peptidase_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276:SF96">
        <property type="entry name" value="PEPTIDASE S1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276">
        <property type="entry name" value="POLYSERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0720">Serine protease</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024324310" description="Peptidase S1 domain-containing protein" evidence="6">
        <location>
            <begin position="22"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="7">
        <location>
            <begin position="27"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0791877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="255" mass="27424" checksum="EBD8DD745FFE5230" modified="2020-02-26" version="1">MDTMYLLVAAIFALSLTSVESNLEPRIVGGKKAKISDFPFFVSIRTYPNKYVCGGAIIDDFWVATAAQCVRGVSPNNLFVVAGVAALNETGDRYAVQAVQIHPWFNPTMKTNDTALLKLTRKLSGKNIKKIEMTKEAIKDGKDMELCGHGATGYPFKNASINLMAIELKSIASDQCSTLHNRPITNYNLCTKGKSAKGACVGDVGSPLIVRGGIFGTTKLHGIVSWGTSPCAQGKPDVYSSIAAIRPWIRTVCGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A493</accession>
    <name>A0A5N4A493_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_14097</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Asterix family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A493"/>
    <dbReference type="FunCoup" id="A0A5N4A493">
        <property type="interactions" value="881"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A493"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045048">
        <property type="term" value="P:protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005351">
        <property type="entry name" value="ASTER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13193">
        <property type="entry name" value="CGI-140"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13193:SF0">
        <property type="entry name" value="PAT COMPLEX SUBUNIT ASTERIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03669">
        <property type="entry name" value="ASTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0792136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="110" mass="12274" checksum="4842E5BBA67F919C" modified="2020-02-26" version="1">MIPGNVDPRRPDKVQRYKPANSGSSNTSGEDLTPDYMNILGMIFSMCGLMMRLKWCAWVALYCSCISFANSRLLDDTKQILSSFMLSISAVVMSYLQNPQPMTPPWASSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A570</accession>
    <name>A0A5N4A570_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tubulin-specific chaperone E</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Tubulin-folding cofactor E</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PPYR_14429</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TBCE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A570"/>
    <dbReference type="FunCoup" id="A0A5N4A570">
        <property type="interactions" value="1825"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A570"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17044">
        <property type="entry name" value="Ubl_TBCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.190:FF:000016">
        <property type="entry name" value="Tubulin-folding cofactor E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044079">
        <property type="entry name" value="Ubl_TBCE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18849:SF0">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 410-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18849">
        <property type="entry name" value="LEUCINE RICH REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14580">
        <property type="entry name" value="LRR_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00845">
        <property type="entry name" value="CAP_GLY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CAP-Gly" evidence="10">
        <location>
            <begin position="34"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0792470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="522" mass="59206" checksum="A8AD570D962067A7" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A5A0</accession>
    <name>A0A5N4A5A0_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_14441</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0390 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A5A0"/>
    <dbReference type="FunCoup" id="A0A5N4A5A0">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A5A0"/>
    <dbReference type="OrthoDB" id="6261058at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019034">
        <property type="entry name" value="UPF0390"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16967">
        <property type="entry name" value="LEYDIG CELL TUMOR 10 KDA PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16967:SF1">
        <property type="entry name" value="LEYDIG CELL TUMOR 10 KDA PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09495">
        <property type="entry name" value="DUF2462"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="60"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0792482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="95" mass="10636" checksum="C5F51C62F4DD09AD" modified="2020-02-26" version="1">MAQGKLKVKSKLPPSVKNKKPAQKGKAVTQRANCPIKPKKQKHQEAQKLKQVVTKSVNKSVEEEMRSRAYEGKRPLSKAQEAVANYHKEMGPSKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A6H1</accession>
    <name>A0A5N4A6H1_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_14817</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A6H1"/>
    <dbReference type="InParanoid" id="A0A5N4A6H1"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032134">
        <property type="entry name" value="DUF4816"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21698:SF6">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21698">
        <property type="entry name" value="PROTEIN (PUTATIVE)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16086">
        <property type="entry name" value="DUF4816"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024286378" evidence="2">
        <location>
            <begin position="20"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="409"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0792858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="458" mass="55479" checksum="B265DCF12B19725F" modified="2020-02-26" version="1">MWVYKHLVIVLGIIVFVAGKAIESQGKVAKPIARRVGYDYSPNYGSSGGGFSSGGGGDDGGLGLGAYNTGEEEHHHDDHHHDDHQHDDHHHDVHHHDDHHHDDHHHDPGYWKKKVQWKKGWKKIWKPAKKKIWKPSWKKYHKPIWVPISVPAWKEYQVPDWKQVWKPVWKEIQVPAWKEFQVPDWKKIWKPIWVPVKVPAWKDIEVPAWKKIWIPVWKEIEVPAWKEIQIPAWKKSFVPVWVKEGVHGEHYLGKDHHGNEYTAHDIWKKKLIWKPVWNKYWKTAKKEIWVHDKKLEWKESWKQIWRSAKKQVWIEDKKLAWKEAWKQVWRTEKKQIWVSDKKLEWKPAWKQIWRTEKKQIWVPDKKLEWKEAWKQIWVPDWKEIWVPAWKVIWKPVIIQEWFPTPDHHDDHHHDEHHHVDHHHGWDRKDKQSASKRITKDVSDVQKSAVNNWKFPGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A718</accession>
    <name>A0A5N4A718_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 22">Angiotensin-converting enzyme</fullName>
            <ecNumber evidence="22">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">PPYR_12737</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">1611_PpyrPB1</strain>
            <tissue evidence="24">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>Release of a C-terminal dipeptide, oligopeptide-|-Xaa-Yaa, when Xaa is not Pro, and Yaa is neither Asp nor Glu. Thus, conversion of angiotensin I to angiotensin II, with increase in vasoconstrictor activity, but no action on angiotensin II.</text>
            <dbReference type="EC" id="3.4.15.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="22">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="22">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 21 22">Belongs to the peptidase M2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="22"/>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A718"/>
    <dbReference type="FunCoup" id="A0A5N4A718">
        <property type="interactions" value="51"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A718"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008241">
        <property type="term" value="F:peptidyl-dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06461">
        <property type="entry name" value="M2_ACE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1370.30:FF:000004">
        <property type="entry name" value="Angiotensin-converting enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001548">
        <property type="entry name" value="Peptidase_M2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10514">
        <property type="entry name" value="ANGIOTENSIN-CONVERTING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10514:SF44">
        <property type="entry name" value="ANGIOTENSIN-CONVERTING ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01401">
        <property type="entry name" value="Peptidase_M2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00791">
        <property type="entry name" value="PEPDIPTASEA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52011">
        <property type="entry name" value="PEPTIDASE_M2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 22" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="9 18 21" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10 14 22" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 22" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 17 22" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 22" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3 22" id="KW-0645">Protease</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 23" id="KW-0732">Signal</keyword>
    <keyword evidence="7 17 22" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="23">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024343910" description="Angiotensin-converting enzyme" evidence="23">
        <location>
            <begin position="19"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor 1" evidence="13">
        <location>
            <position position="371"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor 2" evidence="15">
        <location>
            <position position="371"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor 1" evidence="13">
        <location>
            <position position="501"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor 2" evidence="15">
        <location>
            <position position="501"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>chloride</name>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
            <label>1</label>
        </ligand>
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    <feature type="binding site" evidence="20">
        <location>
            <position position="370"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="370"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="374"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="374"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="398"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="398"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="510"/>
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        <ligand>
            <name>chloride</name>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
            <label>1</label>
        </ligand>
    </feature>
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            <position position="58"/>
        </location>
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    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine; partial" evidence="14">
        <location>
            <position position="141"/>
        </location>
    </feature>
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        <location>
            <position position="142"/>
        </location>
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            <begin position="138"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18 21">
        <location>
            <begin position="339"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18 21">
        <location>
            <begin position="526"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00036868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00039858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR601548-1"/>
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        <source>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR601548-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR601548-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
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    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR601548-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR601548-8"/>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01355"/>
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    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU361144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAB0793117.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="622" mass="72228" checksum="378DDC90A9D2238D" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A903</accession>
    <name>A0A5N4A903_PHOPY</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="2" type="ORF">PPYR_13389</name>
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        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
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            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
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            <taxon>Elateroidea</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
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            <end position="855"/>
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            <end position="24"/>
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            <end position="38"/>
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</entry>
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    <accession>A0A5N4A9G5</accession>
    <name>A0A5N4A9G5_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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        <dbReference type="NCBI Taxonomy" id="7054"/>
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        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Pheromone/general odorant binding protein domain"/>
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    </dbReference>
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        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024400973" evidence="1">
        <location>
            <begin position="20"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0793962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="149" mass="17138" checksum="BF5DD469781B36C9" modified="2020-02-26" version="1">MAQLLMFLCFLCAFSQVLPIDIDETHYTIEDYICFNRTGIDKSYMDSHVTADFVLTTGDEKLNKFMACWVVEMKLVDDELQFSHSAWEKYATHNLFKFIGKSDYPNKEELAKKFVNDCKTIESGSDLGNSAILMLNCMLVPFLELMRTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AA08</accession>
    <name>A0A5N4AA08_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">PPYR_13786</name>
    </gene>
    <organism evidence="1 2">
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        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Neoptera</taxon>
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            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
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            <taxon>Elateroidea</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
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                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0794166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AA08"/>
    <dbReference type="FunCoup" id="A0A5N4AA08">
        <property type="interactions" value="7"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AA08"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0794166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="480" mass="54464" checksum="4420E772CB26839B" modified="2020-02-26" version="1">MDREKFQIPSLLCTADQNGAVHGIKPCENSASSKTALCSELDNTDKAYLPTVGRWGCEWPKTSFLGGSKSGESGKCVHHETCYCNETFLINHLGENGVVFNNNNTLSLLDELLDATQVNGPWLVEHPLPLPIWATDPKQILKFESVWHYEKFVSQLEVHIQQVLERHNYNTIGNFMALYQSFKGSGCYNLRDYLHMYSPPITSLHHTCVGLALELWTKLVELNEKYPSLSNYLYLASCEENIETVDDYVQLGDGLEAVSTSLEKEHVLLALRFEIAGRYGVLLCDPGYHISRAITVMQDQLYPHTGQFVQSREAHARKEYNYTFSANSTFVQWSETVTNANGVKAYDTALVYISRPYLTAVDVTERRNLVYNFRSLLSRDSKGGLKAGIYFKLKENHDEFTIFYQNGGVKKRLKYNFGSFAYPIEETTKKVVRECSLQLNLAEDALECILISLAQVLSDQSYIKQLLEINCEINNLAEDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AA25</accession>
    <name>A0A5N4AA25_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cytochrome c oxidase copper chaperone</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PPYR_13396</name>
        <name evidence="17" type="ORF">PPYR_13759</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">1611_PpyrPB1</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">1611_PpyrPB1</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Copper metallochaperone essential for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase. Binds two copper ions and delivers them to the metallochaperone SCO1 which transports the copper ions to the Cu(A) site on the cytochrome c oxidase subunit II (MT-CO2/COX2).</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Interacts with COA1. Interacts with the chaperone CHCHD4; this is important for correct folding and the formation of disulfide bonds that stabilize the structure.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the COX17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0794139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AA25"/>
    <dbReference type="FunCoup" id="A0A5N4AA25">
        <property type="interactions" value="372"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AA25"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016531">
        <property type="term" value="F:copper chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1130:FF:000001">
        <property type="entry name" value="cytochrome c oxidase copper chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1130">
        <property type="entry name" value="CytochromE C oxidase copper chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009069">
        <property type="entry name" value="Cys_alpha_HP_mot_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007745">
        <property type="entry name" value="Cyt_c_oxidase_Cu-chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16719">
        <property type="entry name" value="CYTOCHROME C OXIDASE COPPER CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16719:SF0">
        <property type="entry name" value="CYTOCHROME C OXIDASE COPPER CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05051">
        <property type="entry name" value="COX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47072">
        <property type="entry name" value="Cysteine alpha-hairpin motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7 14" id="KW-0186">Copper</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00055863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00065132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00071062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR607745-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAB0793776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAB0794139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="73" mass="7908" checksum="CBB220D3381A365B" modified="2020-02-26" version="1">MGNISEKVEAASAEITSKSSAPPAEPPKKLKPCCACPETKKVRDACIIENGEENCQDLIQAHKECMRSMGFNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AAG8</accession>
    <name>A0A5N4AAG8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">A to I editase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_11165</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0794326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AAG8"/>
    <dbReference type="FunCoup" id="A0A5N4AAG8">
        <property type="interactions" value="1190"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AAG8"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003726">
        <property type="term" value="F:double-stranded RNA adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008251">
        <property type="term" value="F:tRNA-specific adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006382">
        <property type="term" value="P:adenosine to inosine editing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002466">
        <property type="entry name" value="A_deamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10910:SF62">
        <property type="entry name" value="AT07585P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10910">
        <property type="entry name" value="EUKARYOTE SPECIFIC DSRNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02137">
        <property type="entry name" value="A_deamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00552">
        <property type="entry name" value="ADEAMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50141">
        <property type="entry name" value="A_DEAMIN_EDITASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DRBM" evidence="2">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="A to I editase" evidence="3">
        <location>
            <begin position="130"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0794326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="453" mass="50375" checksum="5F398CA258463EAA" modified="2020-02-26" version="1">MVLNMLYPHVKYECVENGNDASSRFKVIVTIGEDLFTGTGPNKKAAKNAATTIALSKLLGDTGAVLGTTSPYRKQSVTSEQQHLADCISSLIMDKFHDVMKNNSFHTKRKVLAGIVMGKGPDPSTLEVIAVTTGTKCVSGEHISITGVSLNDLHAEILARRCLLLYLYDQLELAFSNEIENNSVFELTSDQQRFRLKPNIQFHLYINTAPCGDARIFSPHEDSEDVDSHPMRASRGKLRSKIEAGEGTIPLPKRVNQTWDGILQGERLMTMSCSDKIARWNVLGLQGALLSQFIEPIYLSSIVLGSLFKEMHLRRALYGRIENTLQGLPPPYLLNRPLMLLTTSLEGRQPSKAPSFAVNWVLGCDTIEIINTTEGKPDNGYSRLCKQNLLNRFTNLCSTVDIEQPHYYSEAKSLASNYNVAKARLFEAFSKAGAGDWVKKPIEQDEFELKAQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ABX6</accession>
    <name>A0A5N4ABX6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Metalloendopeptidase</fullName>
            <ecNumber evidence="11">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PPYR_11672</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="10 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10 11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="11"/>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0794833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ABX6"/>
    <dbReference type="InParanoid" id="A0A5N4ABX6"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04280">
        <property type="entry name" value="ZnMc_astacin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000015">
        <property type="entry name" value="Meprin A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034035">
        <property type="entry name" value="Astacin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF814">
        <property type="entry name" value="MEPRIN A SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 10 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10 11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 10 11" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0732">Signal</keyword>
    <keyword evidence="5 10 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024441423" description="Metalloendopeptidase" evidence="11">
        <location>
            <begin position="26"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12A" evidence="12">
        <location>
            <begin position="55"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAB0794833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="250" mass="28341" checksum="D58C646E3F20A092" modified="2020-02-26" version="1">MIGRLTFSSNMLIIVLLVSLAVVQADTTQVTDDGDLWQESGKLEGDMVLADGLQNGVIDANLRWKDRNIPYELSDDFDEKQKAQINEVLEREFAKTCISVKPRVDESDYVYVTGNNSGCWSQVGRIGGKQNLNLQVIGCVWNHTIVHEFLHAAGFYHQQSSTDRDDFVDIFWENIKPGREHNFNKHNGDKVTSFNEAYDYNSIMHYTKNAFTKNGKATILPKGDPTIPIGVAKVMSEIDIRKVKKMYECE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AC46</accession>
    <name>A0A5N4AC46_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_11739</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0794900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A5N4AC46">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AC46"/>
    <dbReference type="OrthoDB" id="43122at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd13248">
        <property type="entry name" value="PH_PEPP1_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000103">
        <property type="entry name" value="Pleckstrin homology domain-containing family A member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040392">
        <property type="entry name" value="PKHA4-7_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057971">
        <property type="entry name" value="PKHA4-7_TBCA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12752:SF9">
        <property type="entry name" value="KRAMER, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12752">
        <property type="entry name" value="PHOSPHOINOSITOL 3-PHOSPHATE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25541">
        <property type="entry name" value="TBCA_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="6">
        <location>
            <begin position="227"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="67"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="122"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="163"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="802"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1097"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1146"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1289"/>
            <end position="1330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1771"/>
            <end position="1796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2171"/>
            <end position="2198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2230"/>
            <end position="2288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2455"/>
            <end position="2480"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1953"/>
            <end position="1980"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="2019"/>
            <end position="2107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="67"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="167"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="821"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="851"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="864"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1100"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1146"/>
            <end position="1157"/>
        </location>
    </feature>
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</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
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    <name>A0A5N4ACY6_PHOPY</name>
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        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="11" type="ORF">PPYR_11988</name>
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    <organism evidence="11 12">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
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        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="11">1611_PpyrPB1</strain>
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        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
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    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AD64</accession>
    <name>A0A5N4AD64_PHOPY</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_12112</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
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            <taxon>Lampyrinae</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
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    <sequence length="104" mass="11679" checksum="A7CCA35F16A5FE5E" modified="2020-02-26" version="1" fragment="single">MSKGGVIMPKENKMKESSAVSSRPPDSTCFSKLHLNSLWSVWYGVFGTLLQLYIATKCIKKLNGYELLPWPNSSIPYVELNVSLTLLGMAVFFLIFFLLSSLLK</sequence>
</entry>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0795451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ADR6"/>
    <dbReference type="InParanoid" id="A0A5N4ADR6"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026163">
        <property type="entry name" value="Nckap5l"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21740">
        <property type="entry name" value="NCK-ASSOCIATED PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21740:SF8">
        <property type="entry name" value="NCK-ASSOCIATED PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="59"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="167"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="526"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="759"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="263"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="184"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="763"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="899"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0795451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="899" mass="100899" checksum="34FCE3247B8EBA0B" modified="2020-02-26" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AFI1</accession>
    <name>A0A5N4AFI1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-N-acetylhexosaminidase</fullName>
            <ecNumber evidence="3">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PPYR_10138</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="3"/>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AFI1"/>
    <dbReference type="FunCoup" id="A0A5N4AFI1">
        <property type="interactions" value="589"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AFI1"/>
    <dbReference type="OrthoDB" id="428480at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016231">
        <property type="term" value="F:beta-N-acetylglucosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030203">
        <property type="term" value="P:glycosaminoglycan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06562">
        <property type="entry name" value="GH20_HexA_HexB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000063">
        <property type="entry name" value="Beta-hexosaminidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="entry name" value="Chitobiase/beta-hexosaminidase domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029019">
        <property type="entry name" value="HEX_eukaryotic_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600">
        <property type="entry name" value="BETA-HEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600:SF42">
        <property type="entry name" value="BETA-N-ACETYLHEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14845">
        <property type="entry name" value="Glycohydro_20b2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="beta-N-acetylhexosaminidase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024283954" description="beta-N-acetylhexosaminidase" evidence="9">
        <location>
            <begin position="20"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-hexosaminidase eukaryotic type N-terminal" evidence="11">
        <location>
            <begin position="150"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 20 catalytic" evidence="10">
        <location>
            <begin position="225"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR625705-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAB0796077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="603" mass="68708" checksum="1447328565E0FB9A" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AFQ0</accession>
    <name>A0A5N4AFQ0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PPYR_10119</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Trehalose transporter subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AFQ0"/>
    <dbReference type="InParanoid" id="A0A5N4AFQ0"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000055">
        <property type="entry name" value="Facilitated trehalose transporter Tret1-2 homolog"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050549">
        <property type="entry name" value="MFS_Trehalose_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021:SF1">
        <property type="entry name" value="GH07001P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="52"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="250"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="313"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="354"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="387"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="454"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="484"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="509"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="542"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="566"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="648"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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            <end position="706"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="713"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="747"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="787"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="820"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="397"/>
            <end position="842"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0796058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="856" mass="94476" checksum="91E6758EFBE8048B" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-06-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AFU1</accession>
    <name>A0A5N4AFU1_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_10242</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AFU1"/>
    <dbReference type="InParanoid" id="A0A5N4AFU1"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0796181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="120" mass="14368" checksum="B2EB7BA03363BCED" modified="2020-02-26" version="1">MNFRNIQKKERQICSSNQLQFKFNPYHFVSTLLSRYLFFGEKFILTILTCPYVLHQSLGLRTRTTHAISDMFGIDSFKIERATAEISKKSLHEQRNFSFTTFFFIFIWNLNQFNCKLSPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AGR8</accession>
    <name>A0A5N4AGR8_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_10578</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AGR8"/>
    <dbReference type="FunCoup" id="A0A5N4AGR8">
        <property type="interactions" value="261"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AGR8"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05327">
        <property type="entry name" value="retinol-DH_like_SDR_c_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF264">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE SDR FAMILY MEMBER ON CHROMOSOME X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0796517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="363" mass="41016" checksum="1F27A22D6D16B832" modified="2020-02-26" version="1">MVVSISILATACAVILLVLLLIIITALISRKPLKHLLTEIVFEVRYNFLGMLSVLDDLVLQEKENSEELLMSNGKIALITGGTRGIGAQVVRKLLQRDLHVIIGCRNVEAGQKLCEIYRAKGVRTGSFDVQHLDLNSLSSVRAFAKVIKEKYPRINILINNAGIMFGPYKVSEDGYESQLATNYIGHFLLTHLLLPEMIKAGREDKRYSRIVNVSSCAHKLGDIDFEDFNFKKHYIPSQAYAQSKLAQVLFSNYLNSLMRDASRWVGVYSVHPGIVNTDLFNQWHFEVLLNKHVRRLFFKTPETGSISVVYACLSRKLEIATGTYISNSQITSMSASAYSTDLQRRLFEFTMNKLNIREFGVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AGZ8</accession>
    <name>A0A5N4AGZ8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PPYR_10549</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Putative transcription factor required for axon growth and guidance in the central and peripheral nervous systems. Repels CNS axons away from the midline by promoting the expression of the midline repellent sli and its receptor robo.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AGZ8"/>
    <dbReference type="FunCoup" id="A0A5N4AGZ8">
        <property type="interactions" value="195"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AGZ8"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016199">
        <property type="term" value="P:axon midline choice point recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048813">
        <property type="term" value="P:dendrite morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008406">
        <property type="term" value="P:gonad development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035167">
        <property type="term" value="P:larval lymph gland hemopoiesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007526">
        <property type="term" value="P:larval somatic muscle development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045476">
        <property type="term" value="P:nurse cell apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007464">
        <property type="term" value="P:R3/R4 cell fate commitment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045467">
        <property type="term" value="P:R7 cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18315">
        <property type="entry name" value="BTB_POZ_BAB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000091">
        <property type="entry name" value="Lola, isoform F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051095">
        <property type="entry name" value="Dros_DevTransReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23110">
        <property type="entry name" value="BTB DOMAIN TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23110:SF111">
        <property type="entry name" value="LONGITUDINALS LACKING PROTEIN, ISOFORMS F_I_K_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3" id="KW-0221">Differentiation</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BTB" evidence="11">
        <location>
            <begin position="32"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="354"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="115"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="289"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="116"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="152"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="180"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="308"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAB0796488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="421" mass="47560" checksum="6A088A120C8E275D" modified="2020-02-26" version="1">MEDDQQFCLRWNNHQSTLVAVFDTLLENGTLVDCTLAAEGKYLNAHKVVLSACSPYFESLLSQNYDKHPIFILKDVKFQELKAMMDYMYRGEVNISQDQLGALLKAAESLQIKGLSDNKKDSEPRKAAHPPPAKSPTPMSSTLPRVQGLTIEQRRANRSVDEREGSLSPGPRKRKRVRRRSTDDLDNHHDASNSSESHSNPTPNIPIPLPPASSSMKLLTADVPEPVETKSEIMSRHKILPATNEQEIPQVPIIKEKLETHTELMLEPKAEYVEEMNEDSIEDLTLDDDDVSNLDMSNDGAGPSHGNAGEGSSQGFGGWHMGNQNQDEVFLAAQEAVGAHRDSQDYIQLHYLDFKCHTCHKIYKHKGSLKRHLLYECNRKPNFACTLCPYKAKQKVNLDRHWKFIHFMMDKHDAHIKSSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AHN2</accession>
    <name>A0A5N4AHN2_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">EamA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PPYR_10847</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM234 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AHN2"/>
    <dbReference type="FunCoup" id="A0A5N4AHN2">
        <property type="interactions" value="19"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AHN2"/>
    <dbReference type="OrthoDB" id="43458at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018908">
        <property type="entry name" value="TMEM234"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28668">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28668:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10639">
        <property type="entry name" value="TMEM234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0796786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="133" mass="14868" checksum="5DB06F5B52C5BB33" modified="2020-02-26" version="1">MIYEIASLLTVAALWGCTNPLIKRGSKDIVKVKADNCIAQFFLELKYLFTNYKYLLPMGLNQLGSVLYFVLLQSLDLSLMVPVANSLTFVFTAITGKYLGEQSAGQKTYLGMIFILMGTLLCCYDKYLSFSVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AHZ0</accession>
    <name>A0A5N4AHZ0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_10984</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AHZ0"/>
    <dbReference type="FunCoup" id="A0A5N4AHZ0">
        <property type="interactions" value="37"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AHZ0"/>
    <dbReference type="OrthoDB" id="10041077at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd06713">
        <property type="entry name" value="PDZ_tamalin_CYTIP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052122">
        <property type="entry name" value="Intracell_Traff_Signaling_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15963">
        <property type="entry name" value="GENERAL RECEPTOR FOR PHOSPHOINOSITIDES 1-ASSOCIATED SCAFFOLD PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15963:SF5">
        <property type="entry name" value="SHORT SPINDLE 6, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="4">
        <location>
            <begin position="46"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="179"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="269"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="337"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="594"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="272"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="344"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="369"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="616"/>
            <end position="633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0796923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="633" mass="71179" checksum="D155E14AB93CAA1A" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AJ12</accession>
    <name>A0A5N4AJ12_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PPYR_08311</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AJ12"/>
    <dbReference type="FunCoup" id="A0A5N4AJ12">
        <property type="interactions" value="67"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AJ12"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000218">
        <property type="entry name" value="facilitated trehalose transporter Tret1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050549">
        <property type="entry name" value="MFS_Trehalose_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021:SF39">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="318"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="346"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="393"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="429"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="462"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="29"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0797317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="514" mass="56930" checksum="38842453AFDF5890" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AJ46</accession>
    <name>A0A5N4AJ46_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PPYR_08313</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AJ46"/>
    <dbReference type="FunCoup" id="A0A5N4AJ46">
        <property type="interactions" value="54"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AJ46"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20628">
        <property type="entry name" value="CYP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000182">
        <property type="entry name" value="Cytochrome P450 3A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
        <property type="entry name" value="Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291:SF187">
        <property type="entry name" value="CYTOCHROME P450 4AE1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 12 13" id="KW-0349">Heme</keyword>
    <keyword evidence="10 12 13" id="KW-0408">Iron</keyword>
    <keyword evidence="6 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0492">Microsome</keyword>
    <keyword evidence="11 13" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="436"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAB0797319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="490" mass="56233" checksum="127833878B9753DB" modified="2020-02-26" version="1">MLVVLITIVTLCLYVILLWMNQMKYRKQLAQFPGPKPLPLLGNLLLFKSIADIVPVSIRVWKGIQQSFIIYLGPQPRLVVCDPKTAEFVLSSTTIIDKSYEYNFFHDWLGTGLLTSTGQKWKSRRKLLTPAFHFQILEKYVDVFNKQSNILVEKLKERVDAGPFDIFPYVALCTLDIICEAAMGVQINAQKNSTSSYVLSVKEMCRIITERALSVTKMIHFLYKFTWAYQQQRKVLSILQGFTNSIIRSRKSTFTGRTLHERSDEGLSKRVAFLDLLLEYNLSDETVREEVDTFMFEGHDTTAAGISFTLYCLAKHPDVQVQVVEELRTIFSGDKSRESTYQDLQEMKYLEMVIKESMRLYPPVPLFSRILNESASFNGALLPQGFVCALYVLQLHRNPDIFPDPEKFDPDRFLPENSKSRPPYAYVPFSAGLRNCIGQRFAILEMKATISKILRNFEILPVPDHEPQLSIEAILKSYNGLPIVLKARSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AK47</accession>
    <name>A0A5N4AK47_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_08669</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AK47"/>
    <dbReference type="InParanoid" id="A0A5N4AK47"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0797676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="105" mass="11780" checksum="8C56803447214A7C" modified="2020-02-26" version="1">MEEKSYPTPYSTGPTTPLDFDQQQQIPSYPVNQGLQQPPSQYDNHKQPPPLNPYNTAPTVPVPYVAQPQPTVAALNSTLRAHRPRRIFGIRKRKDLYIVLGVVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AKR2</accession>
    <name>A0A5N4AKR2_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="6">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PPYR_08801</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AKR2"/>
    <dbReference type="InParanoid" id="A0A5N4AKR2"/>
    <dbReference type="OrthoDB" id="19653at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00312">
        <property type="entry name" value="Esterase_lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000155">
        <property type="entry name" value="Carboxylic ester hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142:SF1">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024504560" description="Carboxylic ester hydrolase" evidence="6">
        <location>
            <begin position="20"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="7">
        <location>
            <begin position="25"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0797808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="562" mass="63546" checksum="E231929D755DFC8A" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ALI0</accession>
    <name>A0A5N4ALI0_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_09170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ALI0"/>
    <dbReference type="FunCoup" id="A0A5N4ALI0">
        <property type="interactions" value="15"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4ALI0"/>
    <dbReference type="OrthoDB" id="7665616at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23992">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.20">
        <property type="entry name" value="Pheromone/general odorant binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006170">
        <property type="entry name" value="PBP/GOBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036728">
        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01395">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00708">
        <property type="entry name" value="PhBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024462140" evidence="1">
        <location>
            <begin position="21"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0798177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="135" mass="15480" checksum="C7EAE80B37D57A53" modified="2020-02-26" version="1">MKFMLNLIVSFSMVCIMSQAKELSPLVVDHWKAMMRPYHEVCLNETQIDPEIPNRLFGKSQFPDEKLFHCYLECMHEKLKFLVDGKFSVNNMVAAVYMLNAELAQKCVDDAHSVEEKCARSYVLVQCVAIGVAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AM62</accession>
    <name>A0A5N4AM62_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">POPDC1-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_09438</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AM62"/>
    <dbReference type="FunCoup" id="A0A5N4AM62">
        <property type="interactions" value="103"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AM62"/>
    <dbReference type="OrthoDB" id="425611at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042383">
        <property type="term" value="C:sarcolemma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030552">
        <property type="term" value="F:cAMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007507">
        <property type="term" value="P:heart development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051146">
        <property type="term" value="P:striated muscle cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006916">
        <property type="entry name" value="POPDC1-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055272">
        <property type="entry name" value="POPDC1-3_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12101">
        <property type="entry name" value="POPEYE DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12101:SF30">
        <property type="entry name" value="POPEYE DOMAIN-CONTAINING PROTEIN 3-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04831">
        <property type="entry name" value="POPDC1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="POPDC1-3" evidence="6">
        <location>
            <begin position="55"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0798445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="392" mass="44846" checksum="E2C12E0416F744B4" modified="2020-02-26" version="1">MTELGLNGHSKSFARHILAVFSTTNTTWTEDDRHLNETHDSDFWWPWCYQWKDLQHILVHLANVCFVIGYASTSSKKGLLFTHCWLITGLMLVSAWAWNVICAPDVFTWSFAFMLLNLAQVFHILYQLRPVKFDPELEEIYHNLFYPFKVSRLQFKRMVSSDFAQIMSLHAGEAYAMQNLTRPDRLGLLLSGKVNALCDNQFLHPILPCEFLDSPEFESSRNTIDDKFKVSIVAASSCRYVFWQRSALEYLFVKETYLATVLTTLIARDITTKLYAMNNKIVTAKGSHLDIRLPSITSSLTSGGEYKSPIRIKKDNIGTCPGSPDALLGDKCREKIYQKFKENGSILTNGRNISEMEPLTELPSTDDLTSNDVESWLENSSKYHSCEIVDME</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AMK3</accession>
    <name>A0A5N4AMK3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Nuclear receptor subfamily 2 group E member 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PPYR_09524</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the nuclear hormone receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AMK3"/>
    <dbReference type="InParanoid" id="A0A5N4AMK3"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07164">
        <property type="entry name" value="NR_DBD_PNR_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000058">
        <property type="entry name" value="Nuclear Hormone Receptor family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050274">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24083">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="12">
        <location>
            <begin position="12"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="13">
        <location>
            <begin position="220"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAB0798531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="445" mass="50152" checksum="E62D1A92F89351BA" modified="2020-02-26" version="1">MEESVTSSPKNESFCKVCGDKASGKHYGVASCDGCRGFFKRSIRRNLEYVCKENGHCIVDVTRRNQCQACRFKKCLQVNMKRDAVQHERAPRVVTQSALHHHYSLNLPPRVRNCHGTSLFSGIPLHIQTPSVIDHNIGVMSGISSHYLHQSVLFPGMLSSYNKHSFFSSTLGSSTLPYPHKQDPPLLTDGLHIKRIGINIKEDEVTSSEETSNNNEDVRIPSPPNRSRLELPILGDYRSGLRSLDISSLSLFPTENVYESSAKLLFLAVKWARTIPSFLQLSYRDQSILLEESWSELFVLTAAQWALPIDEALLVNNALAPATRQIELEEDARKLHEVITRLTLLRVDHTEHAFLKALVLFKGDSRGLCEPNHVELLQDQTHVMLHEYCSQKYTSYKGRFGKLLLSLLAVQSISRRGLEELLFRQTVGDVAVDRLLGELAKATHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AML7</accession>
    <name>A0A5N4AML7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Partner of bursicon</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_09588</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AML7"/>
    <dbReference type="FunCoup" id="A0A5N4AML7">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AML7"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031395">
        <property type="term" value="C:bursicon neuropeptide hormone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005184">
        <property type="term" value="F:neuropeptide hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034441">
        <property type="entry name" value="Bursicon_suB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41151">
        <property type="entry name" value="PARTNER OF BURSICON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41151:SF1">
        <property type="entry name" value="PARTNER OF BURSICON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0798595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="140" mass="15929" checksum="214AE61B3D1B5B38" modified="2020-02-26" version="1">MDAVAIFSKLFLTIITISRIHTMNDFGEETCETLPSEINIIKEEYDELGRLQRTCHGEIAVNKCEGSCNSQVQPSVITPTGFLKTCYCCRESFLRERVVTLSHCYDPDGMRLNAEELKAMDIKLREPSDCKCFKCGDFSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AND2</accession>
    <name>A0A5N4AND2_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ribose-5-phosphate isomerase</fullName>
            <ecNumber evidence="4">5.3.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Phosphoriboisomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_06717</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>aldehydo-D-ribose 5-phosphate = D-ribulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:14657"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="EC" id="5.3.1.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation; pentose phosphate pathway; D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ribose 5-phosphate isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.6" evidence="4"/>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0798837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AND2"/>
    <dbReference type="FunCoup" id="A0A5N4AND2">
        <property type="interactions" value="1839"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AND2"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00412"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004751">
        <property type="term" value="F:ribose-5-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006014">
        <property type="term" value="P:D-ribose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009052">
        <property type="term" value="P:pentose-phosphate shunt, non-oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01398">
        <property type="entry name" value="RPI_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.260:FF:000018">
        <property type="entry name" value="Ribose-5-phosphate isomerase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1360:FF:000001">
        <property type="entry name" value="Ribose-5-phosphate isomerase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00170">
        <property type="entry name" value="Rib_5P_isom_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020672">
        <property type="entry name" value="Ribose5P_isomerase_typA_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004788">
        <property type="entry name" value="Ribose5P_isomerase_type_A"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001924">
        <property type="entry name" value="PRK00702.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00021">
        <property type="entry name" value="rpiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11934">
        <property type="entry name" value="RIBOSE-5-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11934:SF0">
        <property type="entry name" value="RIBOSE-5-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06026">
        <property type="entry name" value="Rib_5-P_isom_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75445">
        <property type="entry name" value="D-ribose-5-phosphate isomerase (RpiA), lid domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0798837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="240" mass="26013" checksum="A2DC185DE5CA7D64" modified="2020-02-26" version="1">MLSPLEAAKQTAAHKAINKHVENNFVLGIGSGSTIVYAVERLAERVAKENLEVVCIPTSFQAKQLIVKHGLKLGSLDTHPILDVCIDGADEVDANLNIIKGGGACLLEEKIIASCANGLVIIADYTKNSTKLGDQYKKGIPIEVVPMSYVPVRNKIRNTFGGEVNLRMAVAKAGPVITDNGNFILDWVNFKQLDDWKEVNTAIRMIPGVVETGLFLQMAKIVYFGQADGTIKEQTAKDGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ANP1</accession>
    <name>A0A5N4ANP1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">LIM zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PPYR_06783</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0798903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ANP1"/>
    <dbReference type="FunCoup" id="A0A5N4ANP1">
        <property type="interactions" value="9"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4ANP1"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030018">
        <property type="term" value="C:Z disc"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042805">
        <property type="term" value="F:actinin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008307">
        <property type="term" value="F:structural constituent of muscle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007517">
        <property type="term" value="P:muscle organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060537">
        <property type="term" value="P:muscle tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045214">
        <property type="term" value="P:sarcomere organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09326">
        <property type="entry name" value="LIM_CRP_like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000001">
        <property type="entry name" value="Cysteine and glycine-rich protein 1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24215:SF35">
        <property type="entry name" value="MUSCLE LIM PROTEIN MLP84B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24215">
        <property type="entry name" value="RHO-GTPASE-ACTIVATING PROTEIN LRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0440">LIM domain</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0517">Myogenesis</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="9">
        <location>
            <begin position="32"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="9">
        <location>
            <begin position="134"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="9">
        <location>
            <begin position="237"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="9">
        <location>
            <begin position="335"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0798903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="411" mass="43691" checksum="2F762792C4E0FDB3" modified="2020-02-26" version="1">MDTGSHLQENSDVVISGAPLIAKAIAKAPAGEGCPRCGGYVYAAEQMLARGRAFHKSCFKCGVCTKGLDSISVCEGPDKDIYCRVCYGKKFGPKGYGYGQGGGTLQSDIIGLESDQAPRTTVIDTAVIKAAPGQGCPRCGGVVFAAEEVLARGRPWHRKCFKCKDCHKTLDSIIACDGPDRDVYCKTCYGKKWGPHGYGFACGSGFLQTDGLTEDEISASRPFYNPDTTSIKAPPGQGCPRCGGMVFAAEQQLAKGTMWHKKCFNCAECHRPLDSMLACDGPDREIHCRACYGKLFGPKGFGYGHAPTLMSTEGQSTLLFPDARPNSGRKAAPGKGCSRCGYAVYAAEQMISKNGIWHKRCFSCSDCGKSLDSTNLNDAPNGEIYCRGCYGRSFGPKGVGFGMGAGALTMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ANU7</accession>
    <name>A0A5N4ANU7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Persulfide dioxygenase ETHE1, mitochondrial</fullName>
            <ecNumber evidence="13">1.13.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Sulfur dioxygenase ETHE1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PPYR_06879</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">1611_PpyrPB1</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>S-sulfanylglutathione + O2 + H2O = sulfite + glutathione + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:12981"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58905"/>
            <dbReference type="EC" id="1.13.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="12">Homodimer. Monomer. Interacts with TST. May interact with RELA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.18" evidence="13"/>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0798999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ANU7"/>
    <dbReference type="FunCoup" id="A0A5N4ANU7">
        <property type="interactions" value="776"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4ANU7"/>
    <dbReference type="OrthoDB" id="449487at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050313">
        <property type="term" value="F:sulfur dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070813">
        <property type="term" value="P:hydrogen sulfide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07724">
        <property type="entry name" value="POD-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.15.10:FF:000013">
        <property type="entry name" value="Persulfide dioxygenase ETHE1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051682">
        <property type="entry name" value="Mito_Persulfide_Diox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044528">
        <property type="entry name" value="POD-like_MBL-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43084">
        <property type="entry name" value="PERSULFIDE DIOXYGENASE ETHE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43084:SF1">
        <property type="entry name" value="PERSULFIDE DIOXYGENASE ETHE1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="16">
        <location>
            <begin position="39"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00065219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00066686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00067300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00077964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAB0798999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="259" mass="29012" checksum="C49A2ADE4AD48EB1" modified="2020-02-26" version="1">MFAIRNTLHFCNISPIRHLSTIPFSSDFIFRQLFDATSSTYTYLLADTTTREAVLIDPVFEHAGRDAQLCKDLNLNLKYAMNTHMHADHITGTGVLKKLTKCKSVISKASGADADVHVNETDVVTFGRHKLQIFATPGHTNGCITYYSPEQGIAFTGDTLLIRGCGRTDFQEGNSEMLYHNVHKKIFTLPPATQLYPAHDYKGLTSTTVDEEKRLNPRLTKSLQEFVKIMDNLNLPYPKMIDKAVPANKVCGVFELSPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4APP6</accession>
    <name>A0A5N4APP6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mitochondrial import inner membrane translocase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PPYR_07179</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion inner membrane</location>
            <topology evidence="8">Peripheral membrane protein</topology>
            <orientation evidence="8">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the small Tim family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4APP6"/>
    <dbReference type="FunCoup" id="A0A5N4APP6">
        <property type="interactions" value="1643"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4APP6"/>
    <dbReference type="OrthoDB" id="1551503at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim13 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050673">
        <property type="entry name" value="Mito_inner_translocase_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004217">
        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13172">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM9B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0811">Translocation</keyword>
    <keyword evidence="1 8" id="KW-0813">Transport</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Tim10-like" evidence="9">
        <location>
            <begin position="16"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0799299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="96" mass="10937" checksum="E77408E3DA0F6714" modified="2020-02-26" version="1">MSVLPPGTGIDNLDTEQIKTFKDFLISYNKLTELCFKDCVNDFTSRTVKPQEDKCSLNCLEKFLKANQRISQRFQEFQMVANENALAAAQKLGQKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AQM1</accession>
    <name>A0A5N4AQM1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Hyaluronan-mediated motility receptor C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_07443</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AQM1"/>
    <dbReference type="InParanoid" id="A0A5N4AQM1"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005540">
        <property type="term" value="F:hyaluronic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031794">
        <property type="entry name" value="HMMR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026203">
        <property type="entry name" value="IHABP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18956">
        <property type="entry name" value="HYALURONAN MEDIATED MOTILITY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18956:SF6">
        <property type="entry name" value="HYALURONAN MEDIATED MOTILITY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15908">
        <property type="entry name" value="HMMR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hyaluronan-mediated motility receptor C-terminal" evidence="6">
        <location>
            <begin position="453"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="555"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="159"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="329"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="555"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="570"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF15908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0799563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="592" mass="68808" checksum="C1A75E4EBD918799" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ARD5</accession>
    <name>A0A5N4ARD5_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PPYR_07658</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4ARD5"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025398">
        <property type="entry name" value="DUF4371"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45749">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45749:SF23">
        <property type="entry name" value="ZINC FINGER MYM-TYPE PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14291">
        <property type="entry name" value="DUF4371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1264"/>
            <end position="1287"/>
        </location>
    </feature>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="4">
        <location>
            <begin position="135"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4371" evidence="5">
        <location>
            <begin position="550"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="3">
        <location>
            <begin position="1061"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="4">
        <location>
            <begin position="1142"/>
            <end position="1281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0799778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1386" mass="158975" checksum="D8C6277C3622CC1E" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ATG9</accession>
    <name>A0A5N4ATG9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Acyltransferase</fullName>
            <ecNumber evidence="11">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PPYR_06349</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the diacylglycerol acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="11"/>
    <dbReference type="EMBL" id="VVIM01000004">
        <property type="protein sequence ID" value="KAB0800609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ATG9"/>
    <dbReference type="FunCoup" id="A0A5N4ATG9">
        <property type="interactions" value="110"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4ATG9"/>
    <dbReference type="OrthoDB" id="264532at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004144">
        <property type="term" value="F:diacylglycerol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07987">
        <property type="entry name" value="LPLAT_MGAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007130">
        <property type="entry name" value="DAGAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12317:SF79">
        <property type="entry name" value="ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12317">
        <property type="entry name" value="DIACYLGLYCEROL O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03982">
        <property type="entry name" value="DAGAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAB0800609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="345" mass="39365" checksum="9B15ABE34918F457" modified="2020-02-26" version="1">MTMEVLGVKFAPINIPFRRRIQTLSAAAWFITMAFGGFIGLFLAVYMILQTRLWLVTIAYLIWAWGMDRHTCKKGGRRVEWVRSWTWWKYLKEYFPLNLERVPWVELDPKRNYLFCCFPHGMLPTGAFSAFGTNVGGFHDLFPTHKPYVLTLSQHFYMPFFRELAYALGGCCSSADSINWILSQPDGGKAAILAVGGAAESYNCRPGQYRVVLKNRKGFVKLAIKNGAPLVPVISFGETDLFSQVPSPEGSVIRYIQEFIRKLIGIAPALPLGRGFFQYSFGLVPQRKPVTTVVGRPLNVEKIEKPTQDDIDEVHEKFIECLVEMFEEQKHHYIKDADSTVFEIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ATS7</accession>
    <name>A0A5N4ATS7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PPYR_06458</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000004">
        <property type="protein sequence ID" value="KAB0800719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ATS7"/>
    <dbReference type="FunCoup" id="A0A5N4ATS7">
        <property type="interactions" value="63"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4ATS7"/>
    <dbReference type="OrthoDB" id="10012075at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000328">
        <property type="entry name" value="CLUMA_CG000981, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000376">
        <property type="entry name" value="CLUMA_CG000981, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000392">
        <property type="entry name" value="CLUMA_CG000981, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051170">
        <property type="entry name" value="Neural/epithelial_adhesion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231">
        <property type="entry name" value="CTX-RELATED TYPE I TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231:SF253">
        <property type="entry name" value="DPR-INTERACTING PROTEIN ETA, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024270071" description="Ig-like domain-containing protein" evidence="9">
        <location>
            <begin position="22"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="45"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="147"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="241"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0800719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="435" mass="49126" checksum="44D12BCEE89263D7" modified="2020-02-26" version="1">MPSTLLVLALTLAWTTTIVLGKRVRNTEPNRISVMGDFNHEMSYPRFAEPIPNVTVTVGRDALLTCVVDNLRGFKVAWVRVDTQTILSIHHNVITQNPRISLSYNDHRSWYLHIKNVQQADRGWYMCQVNTDPMRSRQGYLQVVVPPSIIDRETSSDMVVLESTNVSLTCKATGFPEPYVMWRREDGEDIRYNGENVNVVDGEILFITKVSRLHMAVYLCIASNGIPPSISKRVQLRVQFPPMLSIPNQLEGAYIGQDVALECHTEAFPTSINYWTTERGDMIVSGDKYEAVSMESGYKKYMMLKIRSVSVSDFGSYKCVAKNSLGETDGVIKLEEIPAPTTIRTTTQFLTVASRKKGRTWGERHERGDSNENRVVGDKNREHLEYGYDDEYTLPSIAPPPIHEDPGAFSSGSRSLIHRLLTLLVVLGLVTLNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AV02</accession>
    <name>A0A5N4AV02_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">Glutamate-gated chloride channel</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">PPYR_05549</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">1611_PpyrPB1</strain>
            <tissue evidence="21">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Postsynaptic cell membrane</location>
            <topology evidence="16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the ligand-gated ion channel (TC 1.A.9) family. Glutamate-gated chloride channel (TC 1.A.9.4) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000003">
        <property type="protein sequence ID" value="KAB0801195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AV02"/>
    <dbReference type="FunCoup" id="A0A5N4AV02">
        <property type="interactions" value="43"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AV02"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034707">
        <property type="term" value="C:chloride channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008068">
        <property type="term" value="F:extracellularly glutamate-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18993">
        <property type="entry name" value="LGIC_ECD_GluCl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19062">
        <property type="entry name" value="LGIC_TM_GluCl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000024">
        <property type="entry name" value="Glutamate-gated chloride channel alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000022">
        <property type="entry name" value="glutamate-gated chloride channel isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044721">
        <property type="entry name" value="GluCl_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00860">
        <property type="entry name" value="LIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0868">Chloride</keyword>
    <keyword evidence="11" id="KW-0869">Chloride channel</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="15 18" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 18" id="KW-0406">Ion transport</keyword>
    <keyword evidence="14" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 18" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0770">Synapse</keyword>
    <keyword evidence="3 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 18" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024483031" description="Glutamate-gated chloride channel" evidence="18">
        <location>
            <begin position="20"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="241"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="306"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="417"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="19">
        <location>
            <begin position="31"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="20">
        <location>
            <begin position="248"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00061654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAB0801195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="23">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="447" mass="51667" checksum="D935C9BDE3FDA731" modified="2020-02-26" version="1">MNNRTLFIIIAHVIHVVLCSNPKLNFREKEKEILDQILGPGRYDARIRPSGVNGTDGPAVVHVNIFIRSISKIDDVTMEYSVQLTFREQWLDERLKFNDYGERLKYLTLTQANRVWMPDLFFSNEKEGHFHDIIMPNVYIRIYPDGSVLYSIRISLTLSCPMNLKLYPLDRQICSLRMASYGWTTADLVFLWKEVDPVQVVKNLHLPRFTLEKFLTDYCNSKTNTGEYSCLKVDLLFKREFSYYLIQIYIPCCMLVIVSWVSFWLDQGAVPARVSLGVTTLLTMATQTSGINASLPPVSYTKAIDVWTGVCLTFVFGALLEFALVNYASRSDMHRENMKKQRRQCELEHAASMDATSDLMDSDSNATFAMKPLVRHPGDPLSMEKVRQCEIHMQPARPNCCRSWLSKFPTRSKRIDVISRITFPLVFALFNVIYWSTYLFREEAEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AVK9</accession>
    <name>A0A5N4AVK9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Peptidase C1A papain C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_05759</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000003">
        <property type="protein sequence ID" value="KAB0801405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AVK9"/>
    <dbReference type="FunCoup" id="A0A5N4AVK9">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AVK9"/>
    <dbReference type="OrthoDB" id="190265at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000006">
        <property type="entry name" value="Cathepsin S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Cathepsin propeptide inhibitor" evidence="8">
        <location>
            <begin position="63"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="7">
        <location>
            <begin position="153"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0801405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="364" mass="41974" checksum="81940A3E35B880D9" modified="2020-02-26" version="1">MLTHSNYNKVSQSMGMMSHLLFIIICSYRSEMIALFHILFLTLSLTHCQIFHLPSSTELNKLWHDFKRSFNKTYVGYHEERRRQAWEENLQRIVEHNKDAHKGKHSYFININDLSDLNTRTYLQKMVKLTQSTRRKLENPEVVGDFYEMAHHIPDEFDWRKAGFKTPIYNQKDCGSCYAFSVALALQAQIFKQTNQLVPLSAQQLVDCSVSAGNYGCGGGSLRNTLRYLDQSGGLMTYKDYPYIAKQTRCHFDQHRAIVNLSSWAILPARNERAMEIAIYKIGPIAASINASPHTFQLYHSGVYDDPFCSPNTVNHAMLVVGYTKDAWILKNWWGNRWGEDGYMRLRRGANRCGIANFVAYGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AWN2</accession>
    <name>A0A5N4AWN2_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PiggyBac transposable element-derived protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_03930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0801744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AWN2"/>
    <dbReference type="FunCoup" id="A0A5N4AWN2">
        <property type="interactions" value="50"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AWN2"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052638">
        <property type="entry name" value="PiggyBac_TE-derived"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47055">
        <property type="entry name" value="DDE_TNP_1_7 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47055:SF3">
        <property type="entry name" value="PHORBOL-ESTER_DAG-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="1">
        <location>
            <begin position="160"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0801744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="612" mass="71672" checksum="6091D9F02D24687D" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AWQ9</accession>
    <name>A0A5N4AWQ9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">Histone H4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PPYR_03978</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">1611_PpyrPB1</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 12">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the histone H4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0801792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AWQ9"/>
    <dbReference type="InParanoid" id="A0A5N4AWQ9"/>
    <dbReference type="OrthoDB" id="5777208at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22912">
        <property type="entry name" value="HFD_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000002">
        <property type="entry name" value="Histone H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035425">
        <property type="entry name" value="CENP-T/H4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001951">
        <property type="entry name" value="Histone_H4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019809">
        <property type="entry name" value="Histone_H4_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10484">
        <property type="entry name" value="HISTONE H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15511">
        <property type="entry name" value="CENP-T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00623">
        <property type="entry name" value="HISTONEH4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00417">
        <property type="entry name" value="H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00047">
        <property type="entry name" value="HISTONE_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6 12" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0488">Methylation</keyword>
    <keyword evidence="11 12" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="10 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CENP-T/Histone H4 histone fold" evidence="14">
        <location>
            <begin position="44"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF15511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAB0801792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="103" mass="11377" checksum="DF3EB26394D0E08C" modified="2020-02-26" version="1">MTGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVPAMDVVYALKRQGRTLYGFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AWZ8</accession>
    <name>A0A5N4AWZ8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SAM-dependent MTase RsmB/NOP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_04071</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0801885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AWZ8"/>
    <dbReference type="InParanoid" id="A0A5N4AWZ8"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042620">
        <property type="entry name" value="NSUN7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14663">
        <property type="entry name" value="METHYLTRANSFERASE NSUN7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14663:SF2">
        <property type="entry name" value="METHYLTRANSFERASE NSUN7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="598"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="605"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="641"/>
            <end position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0801885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="776" mass="88445" checksum="8ABF44D015A19A1A" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-06-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AX64</accession>
    <name>A0A5N4AX64_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_04093</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0801907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AX64"/>
    <dbReference type="InParanoid" id="A0A5N4AX64"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0801907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="155" mass="18115" checksum="33D088FF241DC137" modified="2020-02-26" version="1">MGNDSAEVRRNLLLSKVGADVFKILFDHFKPEKLIEKTYIQLTTVLNKIYGKKVYIFAERINFAGCFRNENESVTNYMRALAGDCSFGAGLNERMRDQLIFGINNREWQEKIIQKHSTNDRYYFRRSRSDVSHFRTSVHSVKAVKQFTNQSDFGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AXC6</accession>
    <name>A0A5N4AXC6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Snurportin-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PPYR_04187</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Functions as an U snRNP-specific nuclear import adapter. Involved in the trimethylguanosine (m3G)-cap-dependent nuclear import of U snRNPs. Binds specifically to the terminal m3G-cap U snRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the snurportin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AXC6"/>
    <dbReference type="FunCoup" id="A0A5N4AXC6">
        <property type="interactions" value="874"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AXC6"/>
    <dbReference type="OrthoDB" id="10003593at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061015">
        <property type="term" value="P:snRNA import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09232">
        <property type="entry name" value="Snurportin-1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017336">
        <property type="entry name" value="Snurportin-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047857">
        <property type="entry name" value="Snurportin1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13403:SF6">
        <property type="entry name" value="SNURPORTIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13403">
        <property type="entry name" value="SNURPORTIN1 RNUT1 PROTEIN RNA, U TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21974">
        <property type="entry name" value="SPN1_m3Gcap_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Snurportin-1 m3G cap-binding" evidence="11">
        <location>
            <begin position="103"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF21974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAB0802001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="331" mass="39044" checksum="B7FEFF3F4935D456" modified="2020-02-26" version="1">MDSLITSNSEQYTNNELHEEGAPLKSQFADLYKANTLKTLSQSQRRENQLQLLKERRHQSVDEKRNLTDLFHDFKENDHEEQMDVVIPCKTNSKMRYRHLKNKLMLSEWFSDIPNDLELNWLFKLCPSGVRNLVIAYRHKTMAFSIEGKRQAKFISHLPGGGPHSTFNKFTVLDCVYNVAQKCYYVLDVLAWNGFVLKNSNTELRFYWIKSKLNETPELKEATRGNPFTFVEVNFLPAELPLLEEKLSQVHDDEQVSLDGIIFYHREVTYIENRTPLVGWLKPYMVPEMLHIPVHPSFMKHKPRDYICLAHYLQEKHAKKKRPKSSEQMER</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AZH8</accession>
    <name>A0A5N4AZH8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MADF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_04879</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AZH8"/>
    <dbReference type="InParanoid" id="A0A5N4AZH8"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21505">
        <property type="entry name" value="MADF DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21505:SF12">
        <property type="entry name" value="MADF DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00595">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51029">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MADF" evidence="1">
        <location>
            <begin position="10"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0802693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="134" mass="15747" checksum="CE16FB30C858F345" modified="2020-02-26" version="1">MEWEQEKCLQLIAAYGLYPELWQATHKYYYNKLKKNDAWCEIAKQLESNVEIIKAKLNSLLASFRREKARQESTTGTGKGRNEIYRSKWFGFEAFQFLMDKSKCRKSLNTSQNKSKIVEGTPAEETEVKTIFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AZS9</accession>
    <name>A0A5N4AZS9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myotubularin phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_05031</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AZS9"/>
    <dbReference type="FunCoup" id="A0A5N4AZS9">
        <property type="interactions" value="1715"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AZS9"/>
    <dbReference type="OrthoDB" id="271628at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14537">
        <property type="entry name" value="PTP-MTMR10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030564">
        <property type="entry name" value="Myotubularin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010569">
        <property type="entry name" value="Myotubularin-like_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807:SF110">
        <property type="entry name" value="FI17948P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807">
        <property type="entry name" value="MYOTUBULARIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06602">
        <property type="entry name" value="Myotub-related"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51339">
        <property type="entry name" value="PPASE_MYOTUBULARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myotubularin phosphatase" evidence="2">
        <location>
            <begin position="189"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0802845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="644" mass="74095" checksum="659AA8FFC2FCBCF8" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B1H4</accession>
    <name>A0A5N4B1H4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_00338</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B1H4"/>
    <dbReference type="InParanoid" id="A0A5N4B1H4"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12203">
        <property type="entry name" value="GT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044822">
        <property type="entry name" value="Myb_DNA-bind_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21654">
        <property type="entry name" value="FI21293P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21654:SF84">
        <property type="entry name" value="SI:DKEY-66I24.7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13837">
        <property type="entry name" value="Myb_DNA-bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="8">
        <location>
            <begin position="139"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="132"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0803368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="249" mass="28709" checksum="D1893900C34647B5" modified="2020-02-26" version="1">MSHSDQMNAFFCQYDQSPLNLVFGTRSAFPFPPQIKVSNRFNGFNRNFLTLLFISCLFAKIVAFAKMCSGSGNLTLSLQEADVVYDIVVSQEDYNLATTDMIFAQELLNNHKETLQNTVVEKSPEERYLTPSTSTYSEDSQSSEASWSDAETLLLISLYHENKDAFTNAKKRKHVWEIIAEQMSAHNYFRKPEKLERKWTNLLRVYRSIKDNKGPKKSGRGAQHYKYYNHIDEIIGDKPSPLNHKLLLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B1U1</accession>
    <name>A0A5N4B1U1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_00525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B1U1"/>
    <dbReference type="InParanoid" id="A0A5N4B1U1"/>
    <dbReference type="OrthoDB" id="66144at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861:SF1">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="34"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0803555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="269" mass="31114" checksum="C3738C43475056E4" modified="2020-02-26" version="1">MNNPELYDTAGKVLDAQTESIVKNYILQLLRNGDQKVVLDVGSGPGCFSFNYLYKPLSAEIKEMIGIDQSENMVTYANKHYGNDKLKFVKLNIETDCIPEQLLGRFDYVFSFWALHFLHDYTRGFNNIFKMMKPGGYALMVFPGSGQLYDIYKTVWTKPKWSKLIGEDKLMNMPFHNCENPENKLRDISSPLGFESLRCEIQDLSIYLTLETAKDYFASIIPVFSDVPKHLQEELINDHIKEWAPRDISLNEDVMYGLDYKLMVINARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B1U4</accession>
    <name>A0A5N4B1U4_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PPYR_00330</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B1U4"/>
    <dbReference type="InParanoid" id="A0A5N4B1U4"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16495">
        <property type="entry name" value="RING_CH-C4HC3_MARCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20893">
        <property type="entry name" value="LD08641P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20893:SF2">
        <property type="entry name" value="LD08641P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="RING-CH-type" evidence="7">
        <location>
            <begin position="110"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="118"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0803360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="282" mass="31640" checksum="A40C720E36699D82" modified="2020-02-26" version="1">MSPLVNNSQLHQSRVGLLSHALMSIIIVGFLFSETLSEFWKTKVPIKSRNFHDVVFRVVEIGLAVWFPAVLWNCISPGELWLLNPRKLLAKLDQKSWDKSNNGEILPESETFVDKQECWICYDLDKPEPLIQPCGCIGDMSSVHHECLRRWLMESSSGSTEALQCKVCKQAYQVKETNKLDWEKGFTAHHWSSTALIITCLCSAVAAAWTVIQLFDDPYIRMISASLAAFVIYICIRFLGQNTLSAYNRAKVGSLSIGSHVTTISGAVTVDLKTTESEPQNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B2A1</accession>
    <name>A0A5N4B2A1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PiggyBac transposable element-derived protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_00702</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B2A1"/>
    <dbReference type="InParanoid" id="A0A5N4B2A1"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052638">
        <property type="entry name" value="PiggyBac_TE-derived"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47055">
        <property type="entry name" value="DDE_TNP_1_7 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47055:SF3">
        <property type="entry name" value="PHORBOL-ESTER_DAG-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="1">
        <location>
            <begin position="114"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="1">
        <location>
            <begin position="300"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0803732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="409" mass="47123" checksum="C0EE6D697F6A69BE" modified="2020-02-26" version="1">MSKSLPTLSESFTLQEALEMISNEDNVEEIYVEPPEANVLTDEDSGDEDGGGMVDNLSGPQLRAPAEVRFINTTPRVIVPSKLRKLKWINGDIQSVGRAFDYPNSTEFKELSCVQLFEKFIDDDIIKLLVKETQNYALFNNCANPNISAEEIKCFIGILILTGYNHLPGKRYYWDMGSDMRNNLVYNSMRRDRFLQICRFIHCADNNLPDMSDKMWKLRPLMDKIKAKCLSNFQPEENLNYDECMIKYYGRHGCKQFIRGKPIRFGYKMWCFNTASGYLINFDIYQGNNPRRRESAILHNDGIAIVKWVDNGVVTVGSTYFGISPVSNVKRYSQATKSIISVPMPNLSKYNASMGGTDLMDENVNRYRIGVRSKKWWWPIFSWLLDISVHSSYIRNLAVHLYNSLFAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2024-03-27" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B2J3</accession>
    <name>A0A5N4B2J3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4218 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_00792</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B2J3"/>
    <dbReference type="InParanoid" id="A0A5N4B2J3"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33053:SF9">
        <property type="entry name" value="AGAP000105-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33053">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0803822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="705" mass="80039" checksum="3BD86B5BFD7E2CDD" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B4M5</accession>
    <name>A0A5N4B4M5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YqaJ viral recombinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_01537</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B4M5"/>
    <dbReference type="InParanoid" id="A0A5N4B4M5"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd22343">
        <property type="entry name" value="PDDEXK_lambda_exonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051703">
        <property type="entry name" value="NF-kappa-B_Signaling_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019080">
        <property type="entry name" value="YqaJ_viral_recombinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46609">
        <property type="entry name" value="EXONUCLEASE, PHAGE-TYPE/RECB, C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46609:SF8">
        <property type="entry name" value="YQAJ VIRAL RECOMBINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09588">
        <property type="entry name" value="YqaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YqaJ viral recombinase" evidence="2">
        <location>
            <begin position="91"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0804567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="291" mass="33125" checksum="605FEBCD44634F4A" modified="2020-02-26" version="1" fragment="single">NAGAKSTEDDQQTSPTASVKALPASNTDTYDFSFINALKQRLYSNLQLQVPLPLVNLTQSEAIYYKENVVVSVDGALDIAMATVHQNNTLWRMHRKRRITASRCYELFTYCNNANPNWPRKIDSLINSTFTGNAATDYGNSCESLARQVYQCQYGQVHSTGLLINPSIPWLGFSPDGLKMHSGVIYKLIEIKCPVLGKTSGVEGFISELPYLKYDNQQLFPYCLNTNHKYYGQVQLAMFLLNIELCDFVIFSSFDNSIFVIEVERDDVFLQALITKLHYVYFRYYLKMLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B4X4</accession>
    <name>A0A5N4B4X4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">GPI ethanolamine phosphate transferase 2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PPYR_01612</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGG/PIGN/PIGO family. PIGG subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B4X4"/>
    <dbReference type="FunCoup" id="A0A5N4B4X4">
        <property type="interactions" value="856"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4B4X4"/>
    <dbReference type="OrthoDB" id="272139at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051267">
        <property type="term" value="F:CP2 mannose-ethanolamine phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16024">
        <property type="entry name" value="GPI_EPT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037674">
        <property type="entry name" value="PIG-G_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039527">
        <property type="entry name" value="PIGG/GPI7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045687">
        <property type="entry name" value="PIGG/GPI7_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23072:SF0">
        <property type="entry name" value="GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23072">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19316">
        <property type="entry name" value="PIGO_PIGG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="388"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="423"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="466"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="547"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="572"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="661"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="698"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="735"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="766"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="domain" description="GPI ethanolamine phosphate transferase 2 C-terminal" evidence="12">
        <location>
            <begin position="441"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="domain" description="GPI ethanolamine phosphate transferase 2 C-terminal" evidence="12">
        <location>
            <begin position="634"/>
            <end position="767"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF19316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAB0804642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="804" mass="91582" checksum="213FA3B39A13B814" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B551</accession>
    <name>A0A5N4B551_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_01719</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B551"/>
    <dbReference type="InParanoid" id="A0A5N4B551"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF289">
        <property type="entry name" value="DDE TNP4 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="8">
        <location>
            <begin position="83"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0804749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="220" mass="25115" checksum="948CED35A7E9CC16" modified="2020-02-26" version="1">MLLPSKLNFAVSAECMVLLALRYLATGCFLSVAGDFIGIDKSTASRLTTKVCRAIASQHRIFIKMPTTEEEMRERSRGFYMINFRGYLLVGDAGYAIKPYLITPLRNPITRTENLFNESQIRTRNPIERCFGVMKRRFPILSFGIRQRAEKVEAIVIATAVLHNIARNFNDALPDINEEEQEAIAAAEINFEVENVPYYNNGLNNAVRHHLIHEYFNRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B5I6</accession>
    <name>A0A5N4B5I6_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_01839</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B5I6"/>
    <dbReference type="InParanoid" id="A0A5N4B5I6"/>
    <dbReference type="OrthoDB" id="8436363at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052394">
        <property type="entry name" value="LRR-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24114:SF2">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24114">
        <property type="entry name" value="LEUCINE RICH REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="493"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="500"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0804869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="512" mass="58002" checksum="79D83FAF82EE024C" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B602</accession>
    <name>A0A5N4B602_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_02002</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0805032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B602"/>
    <dbReference type="InParanoid" id="A0A5N4B602"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001164">
        <property type="entry name" value="GH01279p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050328">
        <property type="entry name" value="Dev_Immune_Receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373:SF370">
        <property type="entry name" value="FISH-LIPS, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373">
        <property type="entry name" value="SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0805032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="472" mass="53236" checksum="050238983E330B1F" modified="2020-02-26" version="1">MPKTTVTGKSLDDLKKKIGAASKPKTEEITVESSKSASLERSLFQGFDALTALYISGNDIGEIKNNCFEGLTNLKYLYLNNNNIKSLGIECFKGCMRMNELDLSGNQLTKIQAGCFTEFAMTTTCATLNLSNNQIDTIEVGAFKSLTVLYGTLDMSHNRLTKIATDMFHNLLIEKFDLSNNKIDTIEENGLFGSNFKFLHLENNGLVNVHPEAFHRCEIQSELHLELNKLSNYSTIFKSLKNLKELYLDDNGITELPADGFLGLNNLDTLYLNKNDCILTKDAFMGLPNLETLHLEENGLSTIKPGTFNRLQNLRNLNLSYNNFTDLAPNTFWQASNEDEKTYLFTLSLHHNDISKITPGAFGGIDRIEDLQLYGNKIKAFVPGAWKDLSYVGCIQLQNNDISDKAILHQLSPCRQVKLGGNQIEINVSSLYPNDLKLKDIEMISFNYCCYRLENGKWKFDDRFQESVIIPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B6C0</accession>
    <name>A0A5N4B6C0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="2">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PPYR_02127</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ferrochelatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="2"/>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0805157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4B6C0"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004325">
        <property type="term" value="F:ferrochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05481">
        <property type="entry name" value="retropepsin_like_LTR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.70:FF:000003">
        <property type="entry name" value="Protein CBG25708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000063">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000026">
        <property type="entry name" value="Transposon Ty3-G Gag-Pol polyprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019772">
        <property type="entry name" value="Ferrochelatase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001995">
        <property type="entry name" value="Peptidase_A2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF7">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50175">
        <property type="entry name" value="ASP_PROT_RETROV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00534">
        <property type="entry name" value="FERROCHELATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Peptidase A2" evidence="9">
        <location>
            <begin position="299"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="10">
        <location>
            <begin position="453"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="11">
        <location>
            <begin position="995"/>
            <end position="1155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAB0805157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1309" mass="151033" checksum="9B5BA644850DFF1D" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B6Q4</accession>
    <name>A0A5N4B6Q4_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_02257</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0805287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B6Q4"/>
    <dbReference type="InParanoid" id="A0A5N4B6Q4"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34239">
        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34239:SF2">
        <property type="entry name" value="TRANSPOSABLE ELEMENT P TRANSPOSASE_THAP9 CONSERVED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="398"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0805287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="439" mass="49569" checksum="4FFF2E1C90B4712C" modified="2020-02-26" version="1">MGKNKKRARSNSSDSGDRVSSKKLMKRIKKLEIELKRQRSRSRSNSEGRHRRYRSRTPKPTSSTRSSQSRQCMPRSYSRSPAPKRVVSTRLRESTTTPNLSPDHQRSPRSWSRSPPPKHAAKAERSKEAAVYTEISNNNNKNACSIPSPVANKDMCSVVNSPDRDELQIFCDEELPTMSEDIFNSLGEDPNRVATNSFSLHEKLVTRWDALLTNGLKKGDSQTLLNNYELPSNLKSLCPPKLNLEVKAALQKQNILTDSAYVEIQNQLGKGLTALGKGISLLLDNLNKIPEDTRNPILTNLGDSGRILTNLFHRVSITRRNLLVPYLNKNLKDLTDNTLGSEFLFGSDLNEKLTSAKTLESISKELKLPTSFKSPVKKLTKLGGAKGQPLLRYQNQKPHFHYPARHSGETGPQKSLQAPRRYNNNYAPKKRDGERKKRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B7B5</accession>
    <name>A0A5N4B7B5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Neurotransmitter-gated ion-channel transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PPYR_02210</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0805240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B7B5"/>
    <dbReference type="InParanoid" id="A0A5N4B7B5"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099095">
        <property type="term" value="F:ligand-gated monoatomic anion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19049">
        <property type="entry name" value="LGIC_TM_anion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="12">
        <location>
            <begin position="14"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="13">
        <location>
            <begin position="149"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAB0805240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="273" mass="31364" checksum="0A607F7C4669D3BF" modified="2020-02-26" version="1">MSEEYRILDVDWLHSIWRPDCFFKNAKSVTFHEMTIPNHYLWLYHDKTLLYMSKLTLVLSCAMKFESYPHDTQICSMMIESLSHTDHDLVFIWNVTNPLVVNPDIELPQLDISNNYTADCTIEYSTGNFTCLAIVFNLRRRLGYHLFHTYIPSALIVVMSWISFWIKPEAIPARVTLGVTSLLTLATQNTQSQQSLPPVSYVKAIDVWMSSCSVFVFLSLMEFAVVNNYMGPVATKAMKGYSDEDINSETNNFRVGSGTSLFRKSDTIRYVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B7L1</accession>
    <name>A0A5N4B7L1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Angiotensin-converting enzyme</fullName>
            <ecNumber evidence="13">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PPYR_02514</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">1611_PpyrPB1</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 12 13">Belongs to the peptidase M2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="13"/>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0805544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B7L1"/>
    <dbReference type="InParanoid" id="A0A5N4B7L1"/>
    <dbReference type="OrthoDB" id="10029630at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008241">
        <property type="term" value="F:peptidyl-dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06461">
        <property type="entry name" value="M2_ACE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001548">
        <property type="entry name" value="Peptidase_M2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10514">
        <property type="entry name" value="ANGIOTENSIN-CONVERTING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10514:SF45">
        <property type="entry name" value="ANGIOTENSIN-CONVERTING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01401">
        <property type="entry name" value="Peptidase_M2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00791">
        <property type="entry name" value="PEPDIPTASEA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52011">
        <property type="entry name" value="PEPTIDASE_M2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="3 10 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 6 13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="13" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 14" id="KW-0732">Signal</keyword>
    <keyword evidence="9 13" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024395046" description="Angiotensin-converting enzyme" evidence="14">
        <location>
            <begin position="23"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor 1" evidence="5">
        <location>
            <position position="379"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor 2" evidence="7">
        <location>
            <position position="379"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor 1" evidence="5">
        <location>
            <position position="506"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor 2" evidence="7">
        <location>
            <position position="506"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>chloride</name>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="378"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="378"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="382"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="382"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="406"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="406"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="6">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine; partial" evidence="6">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="143"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10 12">
        <location>
            <begin position="347"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="531"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601548-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601548-10"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601548-11"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601548-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601548-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601548-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601548-8"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAB0805544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="645" mass="75421" checksum="42470E33A95E10AD" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1JRG8</accession>
    <name>A0A1Y1JRG8_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_10809</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
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                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
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            <dbReference type="DOI" id="10.1038/srep38556"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
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        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
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                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
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            <strain evidence="3">1611_PpyrPB1</strain>
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        </source>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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                <person name="Bessho-Uehara M."/>
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                <person name="Debat H.J."/>
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                <person name="Day J.C."/>
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                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
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                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
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                <person name="Sander Lower S.E."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
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                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
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                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Sander Lower S.E."/>
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        <source>
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                <person name="Bessho-Uehara M."/>
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                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
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                <person name="Shigenobu S."/>
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    <dbReference type="InParanoid" id="A0A1Y1KXT4"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036029793" evidence="1">
        <location>
            <begin position="19"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="JAV63707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0794112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="206" mass="23510" checksum="D2FF65C225FFC90B" modified="2017-08-30" version="1">MCVIPFVTIIMCASLAAGNSCERLLSLYESFECGPNDVIENVATSYYCATSPYKTEYAEKLCYFKGRFYRNGETLPRRYARTVFEDVCDYTCRISVELGLGPYFEYGNCDTNETIDVVEGECIHDALSNVDFFNYDWAPVFFTGDQCPFFWIADEPSDLTSDDCSEDSRTCCKYLNYTIKAGRKFRPTDLVECDCTCPPMTECIHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1KZP6</accession>
    <name>A0A1Y1KZP6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Vacuolar protein sorting-associated protein 29</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 13">Vesicle protein sorting 29</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PPYR_02704</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">1611_PpyrPB1</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">1611_PpyrPB1</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Component of the commander complex that is essential for endosomal recycling of transmembrane cargos; the commander complex is composed of the Csubcomplex and the retriever subcomplex. Component of the retriever complex, which is a heterotrimeric complex related to retromer cargo-selective complex (CSC) and essential for retromer-independent retrieval and recycling of numerous cargos. Component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. In the endosomes, retriever complex drives the retrieval and recycling of NxxY-motif-containing cargo proteins by coupling to snx17, a cargo essential for the homeostatic maintenance of numerous cell surface proteins associated with processes that include cell migration, cell adhesion, nutrient supply and cell signaling. The recruitment of the retriever complex to the endosomal membrane involves Cand WASH complexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the VPS29 family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01068657">
        <property type="protein sequence ID" value="JAV66823.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01068656">
        <property type="protein sequence ID" value="JAV66824.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01068655">
        <property type="protein sequence ID" value="JAV66825.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0790904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="FunCoup" id="A0A1Y1KZP6">
        <property type="interactions" value="2202"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1KZP6"/>
    <dbReference type="OrthoDB" id="10258130at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030904">
        <property type="term" value="C:retromer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07394">
        <property type="entry name" value="MPP_Vps29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000009">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024654">
        <property type="entry name" value="Calcineurin-like_PHP_lpxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000979">
        <property type="entry name" value="Phosphodiesterase_MJ0936/Vps29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028661">
        <property type="entry name" value="Vps29"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00040">
        <property type="entry name" value="yfcE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11124">
        <property type="entry name" value="VACUOLAR SORTING PROTEIN VPS29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12850">
        <property type="entry name" value="Metallophos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0967">Endosome</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="14">
        <location>
            <begin position="1"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF12850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="JAV66824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAB0790904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="182" mass="20477" checksum="ABA8F09CD450DE5E" modified="2017-08-30" version="1">MLVLVLGDLHIPHRCSSLPGKFKKLLAPGRIQHILCTGNLCTKESYDYLKTLASDVHVVRGDFDDNLNYPEQKVVTVGQFRIGLSHGHQVVPWGDPESLALIQRQLDVDILISGHTHKFEAYEHENKFYINPGSATGAYNALDTIITPSFVLMDIQNATVVTYVYQLVGDEVKVERIEYKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1L491</accession>
    <name>A0A1Y1L491_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Dual specificity protein phosphatase 19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PPYR_12292</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01067000">
        <property type="protein sequence ID" value="JAV67601.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0795453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1L491"/>
    <dbReference type="FunCoup" id="A0A1Y1L491">
        <property type="interactions" value="402"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1L491"/>
    <dbReference type="OrthoDB" id="10252009at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008579">
        <property type="term" value="F:JUN kinase phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14498">
        <property type="entry name" value="DSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46377">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46377:SF1">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="3">
        <location>
            <begin position="54"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="4">
        <location>
            <begin position="132"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="JAV67601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0795453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="193" mass="21899" checksum="FA79D3C20C433308" modified="2017-08-30" version="1">MDFSQQLQNAKIGLKNVSSVVRYPDGRSFLESRGQNTEIESTVGYVIDTKPDDIPSRITENIYLGSQDCSELEVVTKYNIKHVLSLGVKPFSFAVNHRFVKCLDLPETNILDILQHQCYYFISNAVKLKENVLVHCAAGVSRSSSIVIGYLMVTEKLSYEDAFKFVKSKRSCIKPNCGFENQLKGLEFTEMYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1L591</accession>
    <name>A0A1Y1L591_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Daxx histone-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_06920</name>
        <name evidence="4" type="ORF">PPYR_15376</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01064055">
        <property type="protein sequence ID" value="JAV68843.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01001557">
        <property type="protein sequence ID" value="KAB0790287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1L591"/>
    <dbReference type="InParanoid" id="A0A1Y1L591"/>
    <dbReference type="OrthoDB" id="7492809at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016605">
        <property type="term" value="C:PML body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050681">
        <property type="term" value="F:nuclear androgen receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046378">
        <property type="entry name" value="DAXX_histone-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046426">
        <property type="entry name" value="DAXX_histone-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12766:SF7">
        <property type="entry name" value="DEATH DOMAIN-ASSOCIATED PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12766">
        <property type="entry name" value="DEATH DOMAIN-ASSOCIATED PROTEIN 6 DAXX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20920">
        <property type="entry name" value="DAXX_hist_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Daxx histone-binding" evidence="2">
        <location>
            <begin position="299"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="380"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="JAV68843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0790287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0799040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="403" mass="46782" checksum="15DDE6FAF527A512" modified="2017-08-30" version="1">MDVITLSSSDDESSSYKQPRKRIKLQTLPSKTICLDSSDDEPSQSHLVSKENGITKCEPGAECDNSINSGREEVGHGIAESAPIPLESTEPKTDSADVIEEKLTRFFDKCFKTVTRSDHKELFIQVIPKVKAYYDKLKRLKCNLKDFECVLDRDTNVEYDARTASSRFDQIFQFLKGKINELENTIVIQGPKKQHLKKLEKALRLVNRRIAKLDNAEVNFDDEENSHYLQAAKYKERATKIFRKICEIRKEDPNMDRPLYTKINFTKSKFPEFNRVINKRFRDFLQFPTYYDMDQCLRKCVADKGMQVREEELKSEVKFCFEKLGLSMKQKRSLDLYDSHSDFIAGTEDPAQNNEEVTNRLRENYRNGSKRMEEVLEKYTRMQESGVNPDVSSDSDDSNIDSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LBG2</accession>
    <name>A0A1Y1LBG2_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex</fullName>
            <ecNumber evidence="10">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PPYR_09547</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">1611_PpyrPB1</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">1611_PpyrPB1</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + 2-methylpropanoyl-CoA = N(6)-[(R)-S(8)-2-methylpropanoyldihydrolipoyl]-L-lysyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:18865"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:10497"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57338"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83142"/>
            <dbReference type="EC" id="2.3.1.168"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:18866"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="10"/>
    <dbReference type="EMBL" id="GEZM01063145">
        <property type="protein sequence ID" value="JAV69275.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1LBG2"/>
    <dbReference type="FunCoup" id="A0A1Y1LBG2">
        <property type="interactions" value="1846"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1LBG2"/>
    <dbReference type="OrthoDB" id="202158at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043754">
        <property type="term" value="F:dihydrolipoamide branched chain acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031405">
        <property type="term" value="F:lipoic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000013">
        <property type="entry name" value="Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000027">
        <property type="entry name" value="Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.320.10:FF:000002">
        <property type="entry name" value="Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="entry name" value="E3-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050743">
        <property type="entry name" value="2-oxoacid_DH_E2_comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43178">
        <property type="entry name" value="DIHYDROLIPOAMIDE ACETYLTRANSFERASE COMPONENT OF PYRUVATE DEHYDROGENASE COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43178:SF5">
        <property type="entry name" value="LIPOAMIDE ACYLTRANSFERASE COMPONENT OF BRANCHED-CHAIN ALPHA-KETO ACID DEHYDROGENASE COMPLEX, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
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                <person name="Fallon T.R."/>
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                <person name="Weng J.K."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
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                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
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        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
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                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
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    <reference evidence="13" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
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        </source>
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            <topology evidence="1">Single-pass membrane protein</topology>
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        <text evidence="2">Belongs to the SRP receptor beta subunit family.</text>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="12"/>
            <end position="33"/>
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        <source>
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        </source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
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            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="JAV75596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAB0795475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="238" mass="26889" checksum="D2A56B186DE21548" modified="2017-08-30" version="1">MDRPDSPVYAYMRSMLTILIVFAITCLLFVFYFRRRSYKRGVLLTGLCDSGKTLTFSQLVHGKYVNTQTSMKENVGEYIVKSGSVRVIDIPGHERLRDRFFDQYKSAALGVIYMLDSATVQKDIRDTAEYLYNILSECITSSISSVLIICNKQDLDLSKTSTIIKSMLEKELNAVRLTKGSQLESVDPKGQKTKYLGKKGTDFGFSQLPCNVQFVEASISSDSKNIEDIEMWLAKLCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LYI0</accession>
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        <recommendedName>
            <fullName evidence="6">Transposase domain-containing protein</fullName>
        </recommendedName>
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    <gene>
        <name evidence="4" type="ORF">PPYR_04728</name>
        <name evidence="3" type="ORF">PPYR_15327</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
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            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
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        <property type="protein sequence ID" value="JAV78643.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
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    </dbReference>
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    </dbReference>
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            <end position="25"/>
        </location>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="JAV78664.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAB0790333.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAB0802542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="682" mass="78506" checksum="6CA2D02503A58DA2" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1M307</accession>
    <name>A0A1Y1M307_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA demethylase ALKBH5</fullName>
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        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Alkylated DNA repair protein alkB homolog 5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Alpha-ketoglutarate-dependent dioxygenase alkB homolog 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PPYR_13509</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Photinus pyralis</name>
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        <name type="synonym">Lampyris pyralis</name>
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            <taxon>Arthropoda</taxon>
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            <taxon>Pterygota</taxon>
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            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
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            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">1611_PpyrPB1</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">1611_PpyrPB1</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>an N(6)-methyladenosine in mRNA + 2-oxoglutarate + O2 = an adenosine in mRNA + formaldehyde + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:49520"/>
            <dbReference type="Rhea" id="RHEA-COMP:12414"/>
            <dbReference type="Rhea" id="RHEA-COMP:12417"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74449"/>
            <dbReference type="EC" id="1.14.11.53"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:49521"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the alkB family.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.53" evidence="4"/>
    <dbReference type="EMBL" id="GEZM01043871">
        <property type="protein sequence ID" value="JAV78695.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="JAV78700.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01043867">
        <property type="protein sequence ID" value="JAV78705.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01043866">
        <property type="protein sequence ID" value="JAV78707.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1M307"/>
    <dbReference type="InParanoid" id="A0A1Y1M307"/>
    <dbReference type="OrthoDB" id="271595at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990931">
        <property type="term" value="F:mRNA N6-methyladenosine dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032860">
        <property type="entry name" value="ALKBH5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32074">
        <property type="entry name" value="RNA DEMETHYLASE ALKBH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32074:SF2">
        <property type="entry name" value="RNA DEMETHYLASE ALKBH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-ketoglutarate-dependent dioxygenase AlkB-like" evidence="15">
        <location>
            <begin position="111"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00033313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF13532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="JAV78705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAB0793889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="299" mass="34063" checksum="306F3F79F8138976" modified="2017-08-30" version="1">MDAHFCKTGTIEKLVNSIEQPFVYSARECDRLEAYVRDVINLGSVGCYQHHSIDRTLLRTKYFFGERYTYGAQMSEKRLGLERLYPSNLIEPIPLWIYLYIINPLISANVIEANFVNSAVINEYLPGGCIVSHIDPPHIFDRPIISISLFSDCAMCFGCKFEYKPIRCSEPILRLPLPRGVVTLLSGFAANEITHCIRPEDTTFYRAVILLRRVLPNAPRLSHLSTLLDANNVNLVAASKFKLDNDKTTEGVLKKFCDKYSKVRKGKRGNYGGIMKVHTRKTYFADNKQYANKAYSISE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1M7Y5</accession>
    <name>A0A1Y1M7Y5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fibronectin type III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_11926</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01039881">
        <property type="protein sequence ID" value="JAV81118.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01039878">
        <property type="protein sequence ID" value="JAV81125.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0795087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1M7Y5"/>
    <dbReference type="InParanoid" id="A0A1Y1M7Y5"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032073">
        <property type="entry name" value="FNDC5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21104">
        <property type="entry name" value="FIBRONECTIN TYPE III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21104:SF1">
        <property type="entry name" value="FIBRONECTIN TYPE III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16066">
        <property type="entry name" value="DUF4808"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type III" evidence="3">
        <location>
            <begin position="14"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="JAV81118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0795087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="341" mass="38121" checksum="C42AC141A0927D29" modified="2017-08-30" version="1">MCTPVYRSYGPVVIVRAEEVLLVVLVLTLWVAAIALFFNRWGKIRMLEPYQPKFQQSHRPSCPLAPLSPPGITPQQRMSFSKYNVSCLNDYSGLPSPNPLRRPRQNSVFVGSSTMAFMNPPRRVKSAIDIQHLVLNEYSPTSSSCNSMLPMAASHRDRKPSVSIERPGRRKPSIATSISSYGRNRRPSCCGDRPLFGRHRNFISFDQPILSFDRRRSVATERPSCIVHQPTVSFETPSESLEAPFLVVEPPPSTANSYSTSVVNPSTPFRKTSFSFEQPTVNVERTKQPRMATSLDINVNAISFSRRSSMPDPDRSSPVSITFDETKITAPLLEGLKSSDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1MIC5</accession>
    <name>A0A1Y1MIC5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Trimethyllysine dioxygenase, mitochondrial</fullName>
            <ecNumber evidence="5">1.14.11.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Epsilon-trimethyllysine 2-oxoglutarate dioxygenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">TML hydroxylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">TML-alpha-ketoglutarate dioxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PPYR_13088</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="20 21" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">1611_PpyrPB1</strain>
            <tissue evidence="20">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">1611_PpyrPB1</strain>
            <tissue evidence="20">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Converts trimethyllysine (TML) into hydroxytrimethyllysine (HTML).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>N(6),N(6),N(6)-trimethyl-L-lysine + 2-oxoglutarate + O2 = (3S)-3-hydroxy-N(6),N(6),N(6)-trimethyl-L-lysine + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:14181"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:58100"/>
            <dbReference type="ChEBI" id="CHEBI:141499"/>
            <dbReference type="EC" id="1.14.11.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amine and polyamine biosynthesis; carnitine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the gamma-BBH/TMLD family.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.8" evidence="5"/>
    <dbReference type="EMBL" id="GEZM01030637">
        <property type="protein sequence ID" value="JAV85464.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1MIC5"/>
    <dbReference type="FunCoup" id="A0A1Y1MIC5">
        <property type="interactions" value="239"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1MIC5"/>
    <dbReference type="OrthoDB" id="408743at2759"/>
    <dbReference type="UniPathway" id="UPA00118"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050353">
        <property type="term" value="F:trimethyllysine dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045329">
        <property type="term" value="P:carnitine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00250">
        <property type="entry name" value="CAS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2020.30:FF:000002">
        <property type="entry name" value="Putative gamma-butyrobetaine dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000001">
        <property type="entry name" value="Trimethyllysine dioxygenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2020.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050411">
        <property type="entry name" value="AlphaKG_dependent_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010376">
        <property type="entry name" value="GBBH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038492">
        <property type="entry name" value="GBBH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012776">
        <property type="entry name" value="Trimethyllysine_dOase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02410">
        <property type="entry name" value="carnitine_TMLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696">
        <property type="entry name" value="GAMMA-BUTYROBETAINE HYDROXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696:SF51">
        <property type="entry name" value="TRIMETHYLLYSINE DIOXYGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06155">
        <property type="entry name" value="GBBH-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0124">Carnitine biosynthesis</keyword>
    <keyword evidence="9" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma-butyrobetaine hydroxylase-like N-terminal" evidence="18">
        <location>
            <begin position="43"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="TauD/TfdA-like" evidence="17">
        <location>
            <begin position="153"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005022"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008654"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012267"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022873"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00030363"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00031778"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00032283"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00046008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF06155"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="JAV85464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAB0793468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="400" mass="46566" checksum="B66B28DDB0E98453" modified="2017-08-30" version="1">MIMKATNNYNNNTTLSSLLRTSKVHSPKLTLALLKMENLETVQVEDEWLYVKFGEHGRRFYYLWLRDNCKCEKCYSTFYNQILFNILDIPSDIKPISCEIVKDKLLIIWMDKHKTEYEMKWLESITFPLKHALKTILWDRKVVPKKIPLEFYLNDKDGLKSLISAVTTYGFGIVTGVQNTLEATESVVRHLASVQKTYFGEMWKVTTDSSCNDTSTTNVALLPHNDNTYWSNAAGLQVFHLLNRNGEGGHTILVDGFNIAEKVRKRNVDSFNLLCNSAIESHFIDKDQHYFCTDPVIKLHSATKQLHQIRFNVYDRSPLVSLPEGDIPRYYEAYKLFASEAFDRENQYEIQLEPGDVIFIDNWRVLHGRREFMGTRELGGCYVSRDDYLSRVKQFYPTIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1MQV4</accession>
    <name>A0A1Y1MQV4_PHOPY</name>
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            <fullName evidence="4">Large ribosomal subunit protein bL28m</fullName>
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            <fullName evidence="5">39S ribosomal protein L28, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_06889</name>
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    <organism evidence="6">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
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            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL28 family.</text>
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        <property type="protein sequence ID" value="JAV86885.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KAB0799009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1MQV4"/>
    <dbReference type="FunCoup" id="A0A1Y1MQV4">
        <property type="interactions" value="533"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="361870at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR034704">
        <property type="entry name" value="Ribosomal_bL28/bL31-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13528">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L28, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13528:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL28M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143800">
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    </dbReference>
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        <source>
            <dbReference type="ARBA" id="ARBA00008760"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035538"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="JAV86885.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAB0799009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="276" mass="32039" checksum="30827F893AECFF40" modified="2017-08-30" version="1">MSSQAIKSLALYKRVTEIDRGLGPRLPEAYKKFYKEWKLTEPAAVHSIPEEGKWRRDEVTGQVFPIQNHPIPVRYPAEYNNQIWGGEGVVQGFEKRHKYNRRVPHFWVPALKRSAVYSEVLNKHVSVIITERAVQQIHENYGFDHYLLKTLACDLKSLLALSLKRKILQELSQGCPAYANNPEKQQMILNRYKKYLEAYTPEEINWYGYSFEDACTKYKNLIETQNPVVPLKVVYRAELIEKLKTAAESAIQEDKDISGAASWIQKINPFSKKHET</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1MY33</accession>
    <name>A0A1Y1MY33_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Coiled-coil domain-containing protein 51</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_03004</name>
        <name evidence="5" type="ORF">PPYR_12779</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01020001">
        <property type="protein sequence ID" value="JAV89470.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1MY33"/>
    <dbReference type="InParanoid" id="A0A1Y1MY33"/>
    <dbReference type="OrthoDB" id="6243211at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037660">
        <property type="entry name" value="CCDC51"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28624">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28624:SF1">
        <property type="entry name" value="MITOCHONDRIAL POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="61"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="JAV89470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0791204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0793159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="313" mass="35990" checksum="27E3C1EF0F6A77B5" modified="2017-08-30" version="1">MNAKTKVIAALNTVNQALREQLKWGAAEAPKYVNHVKEEIIYKKAAEANAWYTRILGLDEVKFYQQRVITLQEKLLDVQEKRREIGRQLSEVRRKSNELQEQIHKVKRQEDLQRFLDLMKEETEILKQELSVTDTFNGCDREEREIFTAFTNAVKDSHEKQRAQLEYTKYFGLILSLVGSFLTFAYSTLRKQDLKRFIDERLRVDNGDLSASVLQLQLQEGLKEMRNVSGVIDRDKQLLTLISNNQRELLNRLDNSTLLNVINQNHRETAMVLQAIVHSKAVTSTEPSDSQIILGVGGIAALLGFILLKCVFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1N3C1</accession>
    <name>A0A1Y1N3C1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Prostaglandin reductase 1</fullName>
            <ecNumber evidence="4">1.3.1.48</ecNumber>
            <ecNumber evidence="5">1.3.1.74</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">15-oxoprostaglandin 13-reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Dithiolethione-inducible gene 1 protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Leukotriene B4 12-hydroxydehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">NAD(P)H-dependent alkenal/one oxidoreductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="37" type="ORF">PPYR_12928</name>
    </gene>
    <organism evidence="36">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="36" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="37 38" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="37">1611_PpyrPB1</strain>
            <tissue evidence="37">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="37" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="37">1611_PpyrPB1</strain>
            <tissue evidence="37">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="31">
            <text>(5S,12S)-dihydroxy-(6E,10E,12E,14Z)-eicosatetraenoate + NADP(+) = 12-oxo-(5S)-hydroxy-(6E,8E,10E,14Z)-eicosatetraenoate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51212"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:133974"/>
            <dbReference type="ChEBI" id="CHEBI:133975"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="31">
            <dbReference type="Rhea" id="RHEA:51213"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>13,14-dihydro-15-oxo-PGF2alpha + NADP(+) = 15-oxoprostaglandin F2alpha + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50588"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:133374"/>
            <dbReference type="ChEBI" id="CHEBI:133409"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="27">
            <dbReference type="Rhea" id="RHEA:50590"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="32">
            <text>13,14-dihydro-15-oxo-prostaglandin E1 + NADP(+) = 15-oxoprostaglandin E1 + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50584"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57401"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:133408"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="32">
            <dbReference type="Rhea" id="RHEA:50586"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>13,14-dihydro-15-oxo-prostaglandin F1alpha + NADP(+) = 15-oxoprostaglandin F1alpha + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50592"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:79072"/>
            <dbReference type="ChEBI" id="CHEBI:133411"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="24">
            <dbReference type="Rhea" id="RHEA:50594"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>20-hydroxy-leukotriene B4 + NADP(+) = 12-oxo-20-hydroxy-leukotriene B4 + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51208"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57460"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:133346"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="29">
            <dbReference type="Rhea" id="RHEA:51209"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>4-hydroxynonanal + NADP(+) = (E)-4-hydroxynon-2-enal + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:64736"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58968"/>
            <dbReference type="ChEBI" id="CHEBI:156112"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="28">
            <dbReference type="Rhea" id="RHEA:64738"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="30">
            <text>6-trans-leukotriene B4 + NADP(+) = 12-oxo-(5S)-hydroxy-(6E,8E,10E,14Z)-eicosatetraenoate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51204"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:90723"/>
            <dbReference type="ChEBI" id="CHEBI:133974"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="30">
            <dbReference type="Rhea" id="RHEA:51205"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="33">
            <text>an n-alkanal + NADP(+) = an alk-2-enal + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13737"/>
            <dbReference type="ChEBI" id="CHEBI:12834"/>
            <dbReference type="ChEBI" id="CHEBI:13757"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.3.1.74"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="33">
            <dbReference type="Rhea" id="RHEA:13739"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>decanal + NADP(+) = (2E)-decenal + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50612"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:31457"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:133455"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="21">
            <dbReference type="Rhea" id="RHEA:50614"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>dodecanal + NADP(+) = (2E)-dodecenal + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50784"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:27836"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:133741"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="25">
            <dbReference type="Rhea" id="RHEA:50786"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="34">
            <text>hexanal + NADP(+) = (E)-hex-2-enal + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50776"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28913"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:88528"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="34">
            <dbReference type="Rhea" id="RHEA:50778"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>leukotriene B4 + NADP(+) = 12-oxo-leukotriene B4 + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50608"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57461"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:133309"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:50609"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>nonan-2-one + NADP(+) = (3E)-nonen-2-one + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50616"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:77927"/>
            <dbReference type="ChEBI" id="CHEBI:133457"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="26">
            <dbReference type="Rhea" id="RHEA:50618"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>octanal + NADP(+) = (2E)-octenal + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50780"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17935"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:61748"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="20">
            <dbReference type="Rhea" id="RHEA:50782"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>pentan-2-one + NADP(+) = (E)-pent-3-en-2-one + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50788"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16472"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:145276"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="22">
            <dbReference type="Rhea" id="RHEA:50790"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer or homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NADP-dependent oxidoreductase L4BD family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.48" evidence="4"/>
    <dbReference type="EC" id="1.3.1.74" evidence="5"/>
    <dbReference type="EMBL" id="GEZM01013711">
        <property type="protein sequence ID" value="JAV92352.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1N3C1"/>
    <dbReference type="InParanoid" id="A0A1Y1N3C1"/>
    <dbReference type="OrthoDB" id="809632at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047522">
        <property type="term" value="F:15-oxoprostaglandin 13-reductase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032440">
        <property type="term" value="F:2-alkenal reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006693">
        <property type="term" value="P:prostaglandin metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08294">
        <property type="entry name" value="leukotriene_B4_DH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000121">
        <property type="entry name" value="Prostaglandin reductase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041694">
        <property type="entry name" value="ADH_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045010">
        <property type="entry name" value="MDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014190">
        <property type="entry name" value="PTGR1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205:SF7">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16884">
        <property type="entry name" value="ADH_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="15" id="KW-0379">Hydroxylation</keyword>
    <keyword evidence="14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0521">NADP</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0644">Prostaglandin metabolism</keyword>
    <keyword evidence="38" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="35">
        <location>
            <begin position="18"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00032255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00032297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00033119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00047617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00047742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00047871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00047878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00047903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00048066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00048290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00048387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00048591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00048953"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00049068"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00049070"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00049179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="34">
        <source>
            <dbReference type="ARBA" id="ARBA00049368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="35">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="36">
        <source>
            <dbReference type="EMBL" id="JAV92352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="37">
        <source>
            <dbReference type="EMBL" id="KAB0793308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="38">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="331" mass="36468" checksum="6CAA09DF723AFFE6" modified="2017-08-30" version="1">MVVARKFLLAKHFVGPPNADDFKIVEEELPDLKDGEFLAEAVYLSVDPYMRAYSYRLSEGTPMVGNQVAKIIESKSDDFPVGKYVAAQFDWQTHTISSADGVGSPYILPDLEDLPLSYSLGVLGSPGNTAYFSFLDICKPKAGETVVISGAAGAVGSIVGQIAKMQSCEVIGITGSDDKGQYLVDNFGFDSYVNYKRDNLEEQLKRAAPEGIDCYFDNVAGEISTTVIKQMNMFGRICVCGSISSYNTDISDPPKVSCIQLHMLQKQLVMQGFQVIPYRSRILESINQHLEWLRAGKLKYVETITEGFENMPKAFSEMLEGRNLGKAVVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1N4I6</accession>
    <name>A0A1Y1N4I6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PPYR_00636</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="20 21" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">1611_PpyrPB1</strain>
            <tissue evidence="20">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">1611_PpyrPB1</strain>
            <tissue evidence="20">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 16">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01013059">
        <property type="protein sequence ID" value="JAV92792.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1N4I6"/>
    <dbReference type="FunCoup" id="A0A1Y1N4I6">
        <property type="interactions" value="2194"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1N4I6"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.40.10:FF:000001">
        <property type="entry name" value="protein phosphatase 1B isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.430">
        <property type="entry name" value="Phosphatase 2C, C-terminal domain suprefamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
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        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012911">
        <property type="entry name" value="PP2C_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036580">
        <property type="entry name" value="PP2C_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47992">
        <property type="entry name" value="PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07830">
        <property type="entry name" value="PP2C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81601">
        <property type="entry name" value="Protein serine/threonine phosphatase 2C, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0464">Manganese</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0519">Myristate</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12 16" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="18">
        <location>
            <begin position="23"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="JAV92792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAB0803666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="370" mass="40609" checksum="3EB8D0282D5ED20C" modified="2017-08-30" version="1">MGAFLNKPKTDKLQEHGEGNGLRFGVASMQGWRVEMEDAHMVKTDLGGALKDWSYFAVFDGHAGAKVSAHCAEHLLDAIMQTEEFQEDIMKGIHNGFLDLDNKMRTLPEMTSGEDKSGSTAVCAFVSPRLIYVANCGDSRAVLCRDGNPVFTTQDHKPGLPTERDRIIQAGGSVMIQRVNGSLAVSRALGDYEYKNVAGLGPCEQLVSPEPEIFVRDRDDTLDEFLVLACDGVWDVMSNEDLCQFVHSRLLITSDLQEVTSQVIDTCLYKGSRDNMSIVLVVFPGAPTPSQEAIQAEQELDAIIERSIKEVVSNEGQVSFMRILELFVGMGLEGLPPGGGLAAKRALMAEIYRELCPKQDDSDSDECMYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1N733</accession>
    <name>A0A1Y1N733_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosomal protein L1</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">PPYR_12787</name>
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    <organism evidence="2">
        <name type="scientific">Photinus pyralis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
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            <taxon>Lampyrinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01011416">
        <property type="protein sequence ID" value="JAV93529.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KAB0793167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1N733"/>
    <dbReference type="InParanoid" id="A0A1Y1N733"/>
    <dbReference type="OrthoDB" id="10251727at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_uL1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_uL1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="Ribosomal protein L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="370"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="JAV93529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0793167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="444" mass="51532" checksum="1001A3C4A569F2D7" modified="2017-08-30" version="1">MAKTSLQPRIVKPKLNTNIKKKKLLQSASKAGKSLKILVPKQTKEPKTDREPLKKVPPPLIAKDEEPRNYVKLFKFPFDKKQIFQGVIALFKVLKKVQTKQELFDEAQEIYLQVTCVKIPQTPTRLLRFNLKHGLLTDTGDICLIVADKGVKKDHDSTIEYYETILSKHGITNIKTILPFNQFKSEYGMQYELKRKLLGLYDHFLVDSKVGGKVTHLLGSIFYQHRKMPTTVKMDHPNLKQHFENATRTTIMKMHSKGDSYNLQVGHTEMTKRHIYENIMGVLEDFRLHFPGGLENVRGLGVKMARSITIPVYLTLKNKSAVPVPHWERPRPKNYKTAEGELSTELDTVVYVTPEGKVRVKRNKIKEQTDEVTKELENAEQYEDDIETDRSDVKKEEQEQNSDEDNDDLMKAEEEYLVNYEHEQEDDTKKNQKKKAKKEKKVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1NA32</accession>
    <name>A0A1Y1NA32_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphoribulokinase/uridine kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_09816</name>
        <name evidence="3" type="ORF">PPYR_10286</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01010891">
        <property type="protein sequence ID" value="JAV93744.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01010890">
        <property type="protein sequence ID" value="JAV93745.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01010889">
        <property type="protein sequence ID" value="JAV93747.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01010888">
        <property type="protein sequence ID" value="JAV93750.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="OrthoDB" id="10041966at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10285">
        <property type="entry name" value="URIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="JAV93750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0795755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0796225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="213" mass="24721" checksum="C1C78E719A163886" modified="2017-08-30" version="1">MSKNMLIIGISGVTCGGKTTLATKLKKSIPSTLLISQDTYFLAEDDPKHTWIPELNHINYDILSSLDMEQMYRDTIKVTDHYNTNLRNTQMTKSSSLGDSELLQYINTKLKDTQTKVLILEGFCIFNYKPVSNLCLLKYYLTLDREECFERRKLRIYDPPDCPGYFEKCAWPEYLNLRSYVEENVADVNYFTADQNPFRKILADIHNVLCNVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1NAM3</accession>
    <name>A0A1Y1NAM3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Heat shock protein 83</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PPYR_12096</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">1611_PpyrPB1</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">1611_PpyrPB1</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the heat shock protein 90 family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01010662">
        <property type="protein sequence ID" value="JAV93930.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0795257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1NAM3"/>
    <dbReference type="FunCoup" id="A0A1Y1NAM3">
        <property type="interactions" value="1253"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1NAM3"/>
    <dbReference type="OrthoDB" id="5426351at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16927">
        <property type="entry name" value="HATPase_Hsp90-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.80:FF:000003">
        <property type="entry name" value="endoplasmin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.790:FF:000003">
        <property type="entry name" value="Heat shock protein 90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000005">
        <property type="entry name" value="Heat shock protein 90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11260:FF:000001">
        <property type="entry name" value="Heat shock protein 90 alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.790">
        <property type="entry name" value="Heat shock protein 90, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00505">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019805">
        <property type="entry name" value="Heat_shock_protein_90_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037196">
        <property type="entry name" value="HSP90_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001404">
        <property type="entry name" value="Hsp90_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020575">
        <property type="entry name" value="Hsp90_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003555">
        <property type="entry name" value="PRK05218.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11528">
        <property type="entry name" value="HEAT SHOCK PROTEIN 90 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00183">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002583">
        <property type="entry name" value="Hsp90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00775">
        <property type="entry name" value="HEATSHOCK90"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110942">
        <property type="entry name" value="HSP90 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00298">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0346">Stress response</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033751239" description="Heat shock protein 83" evidence="12">
        <location>
            <begin position="21"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase/HSP90-like ATPase" evidence="13">
        <location>
            <begin position="97"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="294"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="744"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="294"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="751"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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    <feature type="binding site" evidence="10">
        <location>
            <begin position="170"/>
            <end position="171"/>
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        <ligand>
            <name>ATP</name>
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        <location>
            <begin position="194"/>
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        <ligand>
            <name>ATP</name>
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        <location>
            <position position="245"/>
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        <ligand>
            <name>ATP</name>
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        <location>
            <position position="448"/>
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        <ligand>
            <name>ATP</name>
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        <source>
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        <source>
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        <source>
            <dbReference type="EMBL" id="JAV93930.1"/>
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        <source>
            <dbReference type="EMBL" id="KAB0795257.1"/>
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    <sequence length="783" mass="89537" checksum="477B650881DC416E" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1NF38</accession>
    <name>A0A1Y1NF38_PHOPY</name>
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        <recommendedName>
            <fullName evidence="12">Glycoside hydrolase family 31 N-terminal domain-containing protein</fullName>
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        <name evidence="10" type="ORF">PPYR_06720</name>
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    <organism evidence="9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
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            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
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                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
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            <dbReference type="DOI" id="10.1038/srep38556"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
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    <reference evidence="10" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Alpha-glycosidase_related"/>
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        <property type="entry name" value="GH"/>
    </dbReference>
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        <property type="entry name" value="Glyco_hydro_31_C"/>
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    </dbReference>
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    </dbReference>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
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    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU361185"/>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="JAV95530.1"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAB0798840.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
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    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
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        <name evidence="8" type="ORF">PPYR_15688</name>
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        <name type="scientific">Photinus pyralis</name>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
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            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
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                <person name="Al-Wathiqui N."/>
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                <person name="South A."/>
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                <person name="Lewis S.M."/>
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            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
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            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01000734">
        <property type="protein sequence ID" value="JAV98292.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01002059">
        <property type="protein sequence ID" value="KAB0790019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1NK35"/>
    <dbReference type="InParanoid" id="A0A1Y1NK35"/>
    <dbReference type="OrthoDB" id="6761697at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="InterPro" id="IPR057251">
        <property type="entry name" value="FP_C"/>
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    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
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    <dbReference type="Pfam" id="PF25298">
        <property type="entry name" value="Baculo_FP_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger PHD-type" evidence="6">
        <location>
            <begin position="2"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="100"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="64"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="JAV98292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0790019.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="294" mass="33725" checksum="4FFFEB7E31B9C12A" modified="2017-08-30" version="1">MKCNRCDQDILSTEVQCRGCKSEYHFVCSISEATYRAKSKSAKATWRCAVCRSAKNAVTGSATVDEDGDEGDSDTNEESSQSKVTLDAILKSIQFMSNKFDNLSSRFDQSIQENQELKEEIKGLKRMLERKDEQIAELDVRVNVLEQRSKRKYVEIHGVSDNDQISPENQFEKIAQSVGCGNITPITVTKIKLANSSFLLAKMESAELKRTFLKKGKQWWANLSELEKKSNAKLYFNENLTPQNRKMLKEAKIRAKIYNFKYVWVSEGRILVRKDDNQRAFRINSLSDVNKYIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1NKE1</accession>
    <name>A0A1Y1NKE1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_04967</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01002890">
        <property type="protein sequence ID" value="JAV97085.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1NKE1"/>
    <dbReference type="FunCoup" id="A0A1Y1NKE1">
        <property type="interactions" value="154"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1NKE1"/>
    <dbReference type="OrthoDB" id="10258156at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052220">
        <property type="entry name" value="METTL25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12496">
        <property type="entry name" value="CGI-41 METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12496:SF9">
        <property type="entry name" value="METHYLTRANSFERASE-LIKE PROTEIN 25-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13679">
        <property type="entry name" value="Methyltransf_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="124"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="JAV97085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0802781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="466" mass="53375" checksum="D8BF7E69C5551825" modified="2017-08-30" version="1">MLPSLNCIKKEIDNLILILEPLLPLVNSHMVDYFINSRYKTSVPLPLQNDICNIGCDNAIDILLKGTPNPCAFHLNDYINRAKSCQLYNLSMVCLSQSDLHRKFFEWGGGDVESLKLKVFVTEKKSHEIELLTKVVATIYNISKTTHIIDVGCGKGYLSSLLALHHQIPVLGVDSSLLHTDGAIKRARLLEKAWKGFQHNPYKSLPSKTEDNLTKIDHLYKQVTQFVTEDTDFEQLISDIFLQRSTNFGLVGLHTCGDLAAACIKMYNRNNNLKTLCNVSCCYNLLNEEFESVNSKSTHSFGFPLSAHLRNKRFKLGHIALMLSAQPVDRILNRKELPSKILFYRSVLEVILEKYNICKSKRQVGKVKKKCENFVEYVHICLKNINVKLDLSNDELMKVYHEYETYENQLYVFYLLRCMLAPLIEAIILLDRLLFLHENGHANAFLTQLFDPIISPRCYALISLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1NMK0</accession>
    <name>A0A1Y1NMK0_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_12440</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01001821">
        <property type="protein sequence ID" value="JAV97506.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0795601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1NMK0"/>
    <dbReference type="InParanoid" id="A0A1Y1NMK0"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006623">
        <property type="entry name" value="THEG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14912">
        <property type="entry name" value="THEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="JAV97506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0795601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="115" mass="13150" checksum="1AA8381FBBFCEFC2" modified="2017-08-30" version="1">MESTKKSVKHTLNELSSPKTSRVTGKHVAPIYKRGSIDSGVKRSAIRGTIRDIRRLNQLAKPYRYLENALDRYKDLVPPQSKKEPPRDIKAEVSPKALKYIASDRIKELAQPIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N3ZY40</accession>
    <name>A0A5N3ZY40_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein VAC14 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PPYR_04664</name>
        <name evidence="9" type="ORF">PPYR_15743</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Scaffold protein component of the PI(3,5)P2 regulatory complex which regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Pentamerizes into a star-shaped structure and nucleates the assembly of the complex. The pentamer binds a single copy each of PIKFYVE and FIG4 and coordinates both PIKfyve kinase activity and FIG4 phosphatase activity, being required to maintain normal levels of phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 5-phosphate (PtdIns(5)P). Plays a role in the biogenesis of endosome carrier vesicles (ECV) / multivesicular bodies (MVB) transport intermediates from early endosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Forms pentamers. Component of the PI(3,5)P2 regulatory complex/PAS complex, at least composed of PIKFYVE, FIG4 and VAC14. VAC14 nucleates the assembly of the complex and serves as a scaffold by pentamerizing into a star-shaped structure, which can bind a single copy each of PIKFYVE and FIG4 and coordinates their activities. Interacts with NOS1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VAC14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01002126">
        <property type="protein sequence ID" value="KAB0789973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N3ZY40"/>
    <dbReference type="FunCoup" id="A0A5N3ZY40">
        <property type="interactions" value="1592"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N3ZY40"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070772">
        <property type="term" value="C:PAS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006661">
        <property type="term" value="P:phosphatidylinositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026825">
        <property type="entry name" value="Vac14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021841">
        <property type="entry name" value="VAC14_Fig4p-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16023:SF0">
        <property type="entry name" value="PROTEIN VAC14 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16023">
        <property type="entry name" value="TAX1 BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12755">
        <property type="entry name" value="Vac14_Fab1_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11916">
        <property type="entry name" value="Vac14_Fig4_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Vacuolar protein 14 C-terminal Fig4-binding" evidence="8">
        <location>
            <begin position="477"/>
            <end position="654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00045654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF11916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0789973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0802478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="719" mass="80976" checksum="0AD6EAEEC342CD18" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N3ZYM4</accession>
    <name>A0A5N3ZYM4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PPYR_15517</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01001797">
        <property type="protein sequence ID" value="KAB0790163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N3ZYM4"/>
    <dbReference type="InParanoid" id="A0A5N3ZYM4"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000003">
        <property type="entry name" value="Solute carrier family 17 member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050382">
        <property type="entry name" value="MFS_Na/Anion_cotransporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662:SF280">
        <property type="entry name" value="FI21844P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0769">Symport</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="153"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0790163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="225" mass="24550" checksum="7C92F63953BC220C" modified="2020-02-26" version="1" fragment="single">RSPPTPWKAIFTSMPFWAVLIAQFGQAWGFTILITNIPTYMSNVLGFDIKKNGALSAGPYFAFWIFSLLSGVISDYVVSREYVTVGFARKFANTIALCVPGIGLIVLGVIGNAQWDITDAAVILLFISVGFNGSSTCGYHMNHIDLSPVHSGTLMGIASGSTNFLCLFAPLLLQFIVTDEKDAFQWATVFYITSAIYLIGNTVFVVFGSGETQPWNNVEEDDENS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N3ZZ79</accession>
    <name>A0A5N3ZZ79_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_15271</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01001419">
        <property type="protein sequence ID" value="KAB0790366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N3ZZ79"/>
    <dbReference type="InParanoid" id="A0A5N3ZZ79"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF269">
        <property type="entry name" value="NUCLEASE HARBI1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="8">
        <location>
            <begin position="3"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0790366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="120" mass="14023" checksum="791E5C4889EF34CA" modified="2020-02-26" version="1">MPHVIIADEAYPLMKHLLKPYRKQELNADKEYFNKRLSRARRTVECAFGILRSKWQILDKPILTHPGHADNIIKAICILHNLKETQFVFQNENRQAPAGRLNNEAKVVRDNFKAYLCNNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N3ZZD8</accession>
    <name>A0A5N3ZZD8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PPYR_15191</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01001280">
        <property type="protein sequence ID" value="KAB0790435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N3ZZD8"/>
    <dbReference type="InParanoid" id="A0A5N3ZZD8"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007417">
        <property type="term" value="P:central nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000378">
        <property type="entry name" value="Notochord homeobox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050877">
        <property type="entry name" value="EMX-VAX-Noto_Homeobox_TFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24339:SF67">
        <property type="entry name" value="GNOT1 HOMEODOMAIN PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24339">
        <property type="entry name" value="HOMEOBOX PROTEIN EMX-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="7">
        <location>
            <begin position="150"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="152"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0790435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="247" mass="27917" checksum="CB7435ECC2A01B58" modified="2020-02-26" version="1">MLHHYNYSNPLSQFLSFHQLDEQTTPENEHTSSSICDEQIDARYRSSSTSVSSTSKSFTIAAILGLKNDNTTDVQNSPTDLTAVVNLSVHQSAAERALVSSCSRLQLPVRHSSSAVSVTGHYSVASSCSTRHTVRGLKHIPPGVMSKKSCKSKRVRTIFTPEQLERLEAEFERQQYMVGPERLYLAHTLQLTEAQVKVWFQNRRIKWRKHHLELTHQRLAALKQQQLLLSEVQVDNQDTNSSSTDNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A059</accession>
    <name>A0A5N4A059_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Pyruvate kinase</fullName>
            <ecNumber evidence="4 13">2.7.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PPYR_14866</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">1611_PpyrPB1</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>pyruvate + ATP = phosphoenolpyruvate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18157"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.40"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the pyruvate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.40" evidence="4 13"/>
    <dbReference type="EMBL" id="VVIM01000899">
        <property type="protein sequence ID" value="KAB0790686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A059"/>
    <dbReference type="InParanoid" id="A0A5N4A059"/>
    <dbReference type="OrthoDB" id="108365at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004743">
        <property type="term" value="F:pyruvate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.33.10:FF:000023">
        <property type="entry name" value="Pyruvate kinase PKM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.33.10">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.20">
        <property type="entry name" value="Pyruvate kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001697">
        <property type="entry name" value="Pyr_Knase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018209">
        <property type="entry name" value="Pyrv_Knase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015793">
        <property type="entry name" value="Pyrv_Knase_brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015795">
        <property type="entry name" value="Pyrv_Knase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036918">
        <property type="entry name" value="Pyrv_Knase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015806">
        <property type="entry name" value="Pyrv_Knase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01064">
        <property type="entry name" value="pyruv_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11817">
        <property type="entry name" value="PYRUVATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00224">
        <property type="entry name" value="PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02887">
        <property type="entry name" value="PK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01050">
        <property type="entry name" value="PYRUVTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52935">
        <property type="entry name" value="PK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00110">
        <property type="entry name" value="PYRUVATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 13" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="8 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate kinase barrel" evidence="14">
        <location>
            <begin position="25"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Pyruvate kinase C-terminal" evidence="15">
        <location>
            <begin position="390"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAB0790686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="516" mass="56684" checksum="A06F27036CBEA718" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A0L7</accession>
    <name>A0A5N4A0L7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MADF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_15043</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000721">
        <property type="protein sequence ID" value="KAB0790839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A0L7"/>
    <dbReference type="InParanoid" id="A0A5N4A0L7"/>
    <dbReference type="OrthoDB" id="8195830at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039353">
        <property type="entry name" value="TF_Adf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243:SF67">
        <property type="entry name" value="COREPRESSOR OF PANGOLIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243">
        <property type="entry name" value="MADF DOMAIN TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00595">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51029">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MADF" evidence="2">
        <location>
            <begin position="8"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0790839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="275" mass="31296" checksum="E2E1A77B3CCD585D" modified="2020-02-26" version="1">MIDEDDMRLIDVVQQFRQIYDKSSPNFKNKRAKQNAWTTVAQMLERTPVDCESRFTVLRNRFVTEKRKLQVATASGAGGDVVEPSPLYKKLEFLLRFIKSRQTTSNVQMKNAAGQEKPGPSCSATGHRNAQEQTKAGPSNPWDTINTILEGSEVEVEEFYTESNIDDSQEDLDEETHHDIQQSEDKENQEPVARKKRKLDTSGNKTSKKKSPIRGALEASLNKFNTYLAAKQEKADEMIDKELSFGRTVGLYLKELDAETRQAKQLEIMNILFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A1S2</accession>
    <name>A0A5N4A1S2_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_03072</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A1S2"/>
    <dbReference type="InParanoid" id="A0A5N4A1S2"/>
    <dbReference type="OrthoDB" id="7419171at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.30">
        <property type="entry name" value="Haemolymph juvenile hormone binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010562">
        <property type="entry name" value="Haemolymph_juvenile_hormone-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038606">
        <property type="entry name" value="To_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008:SF32">
        <property type="entry name" value="CIRCADIAN CLOCK-CONTROLLED PROTEIN DAYWAKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008">
        <property type="entry name" value="PROTEIN TAKEOUT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06585">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00700">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024437281" evidence="1">
        <location>
            <begin position="25"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0791272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="254" mass="29021" checksum="C108D7879D7DE528" modified="2020-02-26" version="1">MPSGLTLIMLVLISVLSALAVAHCSEDFLGNLQVCKRNDRNIDSCLKNAVSQAVKLLADGYPEHGIQPLEPLKVGGWNVTKGSVLPFDQDYYDMKLHNYSDIVIESVSSKFDDENFYVEIIALGPHMYVDGRYEYYDAILNGVNLTSKGKIEYYYTGYKFYVDLFGKIVKRNGVEYVDITACTVDVLSLDLLRIEFRSENPELDDVITTKFNNIWKELISDNREGYERMYSEKFKEVASSVFSAFRYDKLLPKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A1S8</accession>
    <name>A0A5N4A1S8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Spermidine synthase</fullName>
            <ecNumber evidence="4">2.5.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Putrescine aminopropyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PPYR_03051</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM). Has a strong preference for putrescine as substrate, and has very low activity towards 1,3-diaminopropane. Has extremely low activity towards spermidine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>S-adenosyl 3-(methylsulfanyl)propylamine + putrescine = S-methyl-5'-thioadenosine + spermidine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12721"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:57443"/>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
            <dbReference type="ChEBI" id="CHEBI:326268"/>
            <dbReference type="EC" id="2.5.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amine and polyamine biosynthesis; spermidine biosynthesis; spermidine from putrescine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer or homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the spermidine/spermine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.16" evidence="4"/>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A1S8"/>
    <dbReference type="FunCoup" id="A0A5N4A1S8">
        <property type="interactions" value="1166"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A1S8"/>
    <dbReference type="OrthoDB" id="38125at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004766">
        <property type="term" value="F:spermidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008295">
        <property type="term" value="P:spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.140.10:FF:000001">
        <property type="entry name" value="SPE3p Spermidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000013">
        <property type="entry name" value="Spermidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.140.10">
        <property type="entry name" value="Spermidine synthase, tetramerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00198">
        <property type="entry name" value="Spermidine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030374">
        <property type="entry name" value="PABS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030373">
        <property type="entry name" value="PABS_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001045">
        <property type="entry name" value="Spermi_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035246">
        <property type="entry name" value="Spermidine_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037163">
        <property type="entry name" value="Spermidine_synt_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF037959">
        <property type="entry name" value="MFS_SpdSyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002010">
        <property type="entry name" value="PRK00811.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00417">
        <property type="entry name" value="speE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11558:SF11">
        <property type="entry name" value="SPERMIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11558">
        <property type="entry name" value="SPERMIDINE/SPERMINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17284">
        <property type="entry name" value="Spermine_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01564">
        <property type="entry name" value="Spermine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01330">
        <property type="entry name" value="PABS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51006">
        <property type="entry name" value="PABS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PABS" evidence="12">
        <location>
            <begin position="6"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00053963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00072554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00082964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAB0791251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="288" mass="32161" checksum="6040EBC0C1ACD7EF" modified="2020-02-26" version="1">MEQIRGGYFSEKNDLWPGQFFSLEVEKVLHTEKSEYQDILIVQTTHHGKALILDGLIQCTEHDEFAYQEMISFLPLCAHENPAKVLIVGGGDGGVAREVSKHPLVQSVVQVEIDARVIEASKRYLPSMSVGFSSPKLTLNVCDGFEYMRNHKGEFDVIITDSSDPIGPAVNLFTKSYFKLLKEALKPDGIVCSQGSSLWLSLEHVKGTMQNCRQHFDTVKFGVANVPSYPTGQIGFVIGALGENRPLESPTLTFTDEEIARMKLRYYNGDVHRAAFVLPTFARNALYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A1T4</accession>
    <name>A0A5N4A1T4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">H/ACA ribonucleoprotein complex subunit 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Nucleolar protein 10</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Nucleolar protein family A member 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">snoRNP protein NOP10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PPYR_03085</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOP10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A1T4"/>
    <dbReference type="FunCoup" id="A0A5N4A1T4">
        <property type="interactions" value="1272"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A1T4"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070034">
        <property type="term" value="F:telomerase RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904874">
        <property type="term" value="P:positive regulation of telomerase RNA localization to Cajal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031118">
        <property type="term" value="P:rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.40:FF:000002">
        <property type="entry name" value="H/ACA ribonucleoprotein complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.40">
        <property type="entry name" value="H/ACA ribonucleoprotein complex, subunit Nop10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007264">
        <property type="entry name" value="H/ACA_rnp_Nop10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036756">
        <property type="entry name" value="H/ACA_rnp_Nop10_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13305:SF0">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13305">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN NOP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04135">
        <property type="entry name" value="Nop10p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144210">
        <property type="entry name" value="Nop10-like SnoRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00071541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0791285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="64" mass="7530" checksum="77805218CB98F1F6" modified="2020-02-26" version="1">MYLMYYIDDSGKRVYTLKKTDLVGKPTMTAHPARFSPEDKYSRERLTIKKRFGILLTQTPEPEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A1W7</accession>
    <name>A0A5N4A1W7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Neurotransmitter-gated ion-channel ligand-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PPYR_03123</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A1W7"/>
    <dbReference type="InParanoid" id="A0A5N4A1W7"/>
    <dbReference type="OrthoDB" id="5975154at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18989">
        <property type="entry name" value="LGIC_ECD_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000028">
        <property type="entry name" value="AcetylCholine Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024336582" description="Neurotransmitter-gated ion-channel ligand-binding domain-containing protein" evidence="6">
        <location>
            <begin position="19"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="274"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="304"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="394"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="7">
        <location>
            <begin position="41"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0791323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="412" mass="46538" checksum="995BFA8B4146825E" modified="2020-02-26" version="1">MIRLLIVIAWFYVSCARGDGVHDHGRRTVSNPLWNETSLDKLRNDLLLNYDKFAKAVEGNVTEVGIGLTIVYVETDELNSTFTSSMWLKLSWKDPKLVWSSQDYNGIDSLKMADHEIWQPDIYLFNGANTGGEPIIRYGNPYALVQPDGSVVWVPPIKLTALCDFDMYYWPFDTQRCYLRFGSGSRSRADIRLVSKGVDFKTAIPIVQWTIACTDTIVEVTRAGYPDQFYHVLYNLTLTRKPSTTTTVATTVICCSACLVLAQRFLTFKTGRGLILRCLTSVVLCIFLVYFGTRVAPKRSAAPWIVSFLSACLFLHCITVIESVMVTCMSKLSNPKRVAWKVKGWLGGRFGRILLLDDCIVECERCVDSTDDQHGGKCAASHDWELCHIAIDRLLFLIYFLILALLILAYII</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A221</accession>
    <name>A0A5N4A221_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nose resistant-to-fluoxetine protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_03118</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A221"/>
    <dbReference type="InParanoid" id="A0A5N4A221"/>
    <dbReference type="OrthoDB" id="118951at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006621">
        <property type="entry name" value="Nose-resist-to-fluoxetine_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052728">
        <property type="entry name" value="O2_lipid_transport_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161">
        <property type="entry name" value="O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161:SF0">
        <property type="entry name" value="O-ACYLTRANSFERASE LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20146">
        <property type="entry name" value="NRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00703">
        <property type="entry name" value="NRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024317458" description="Nose resistant-to-fluoxetine protein N-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="299"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="398"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="424"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="Nose resistant-to-fluoxetine protein N-terminal" evidence="3">
        <location>
            <begin position="50"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0791318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="457" mass="51906" checksum="41BA954D6EBD8F0F" modified="2020-02-26" version="1">MAPQKLLCLILLVAGTKGDVFDYNFEALSSPRMLSDALESFLLLNATAVSWNCSVQLSEYVVGLRSREEWALKMYDSNGKLPAGVLDGNLAELGSFDECLYVTKLNEEPKGSSFTGQYCMGSIHVNATQNISAEIKLPERLNLMVFSTCLPDACSATDVQNLIRGFGINLTTYDTYCQILAERPELDVGGIFGLTIFVCLALLMVASTIYDLRKKFLEKKTPNALLSAFSVYTNLKNIFNTKSASKEITCLHGLRSIAIIVVIAFHRYLNSFGIKYRNDFYINHWVHQTQNMPLVKSDFALDVFFFLSGSMITYGFCQKMARQQRFRIMLHYVNRYVRLTPSMAIVALFVATVTKYLGSGPLWPDFNENIIEPCVHSWWYNMLYIQIFTLPMCLPHSWYVAVDFEFFLLTPLLLIPLRRWPMKALVTTAFLDVCCVAFVFALAWIAEFRVATQYNNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A2A6</accession>
    <name>A0A5N4A2A6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PPYR_03247</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A2A6"/>
    <dbReference type="InParanoid" id="A0A5N4A2A6"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001156">
        <property type="entry name" value="Zinc finger protein 407"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012934">
        <property type="entry name" value="Znf_AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379:SF121">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379">
        <property type="entry name" value="KRAB AND ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00868">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="172"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="200"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="228"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="256"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAB0791447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="309" mass="37060" checksum="1685FFAB10298F56" modified="2020-02-26" version="1">MEEAGKNICRFCLAFIPLNSELHLVKDLEKDLLDCLPELNLHIPLEPISCQRCFDDIQSMYAFKRRFLTTKRLLQELADEHGPITTDNVLEYVKGKSEHLERTEDGDVDLNTGNTTNVKEEAPNRLRRRRIIIKFFRCRDCRRKLFKRNRRGFPVNTLINRKRRVVDRREKYKCEQCEFVTVYKHRHRSHLQAHVQLKPFQCYDCNYCTNRKDNLAQHVKIHADFKPYRCDSCDYKSRRLSNLKSHLNKHRNMRPFLCDQCKATFSRKANVKKHILAVHFRSAKLPTLKIHTDFFHYLSSFEIFVFWKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-06-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A341</accession>
    <name>A0A5N4A341_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_03498</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A341"/>
    <dbReference type="InParanoid" id="A0A5N4A341"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0791698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="84" mass="9928" checksum="0D3DF608620981DC" modified="2020-02-26" version="1">MRMRVHRARVESSPTTNILERKLGWRLQHHNRVIVPTMAADYAAVVVKVESKKEEPNLKVEPKEEDDINLSLEEMFRLCRRMTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A3C3</accession>
    <name>A0A5N4A3C3_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_03602</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A3C3"/>
    <dbReference type="InParanoid" id="A0A5N4A3C3"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0791802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="99" mass="10666" checksum="F4C0A3DC5CBF1135" modified="2020-02-26" version="1">MRRLPLDRRVCQTKGGKSTHCGGEHSANNKRVREISASSFKVSQPQPSPPKGRIQTAETRPDTSYATATKDTAPEVPTTASIPTVSQAANPDGKYPVDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A476</accession>
    <name>A0A5N4A476_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PPYR_14084</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">1611_PpyrPB1</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Microsome membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 15">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A476"/>
    <dbReference type="FunCoup" id="A0A5N4A476">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A476"/>
    <dbReference type="OrthoDB" id="1055148at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008395">
        <property type="term" value="F:steroid hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006805">
        <property type="term" value="P:xenobiotic metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000238">
        <property type="entry name" value="Cytochrome P450 2A6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050182">
        <property type="entry name" value="Cytochrome_P450_fam2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300:SF376">
        <property type="entry name" value="CYTOCHROME P450 15A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300">
        <property type="entry name" value="CYTOCHROME P450 508A4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 14 15" id="KW-0349">Heme</keyword>
    <keyword evidence="11 14 15" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0492">Microsome</keyword>
    <keyword evidence="12 15" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="10 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024366845" description="Cytochrome P450" evidence="16">
        <location>
            <begin position="21"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="14">
        <location>
            <position position="438"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAB0792123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="19">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="491" mass="55720" checksum="D529ABB53FF33484" modified="2020-02-26" version="1">MWFILLIVTICLLWLNSRKPRNFPPGPAWLPIIGCGLELNRLRQKSGSMSKAVGALALKYGPVVGARVGVDRVVFVCGPKEYREFSSREEFNGRPNTIFYTCRTWGKPRGVLFTDGEFWEEQRAFIMKHLKEFGMGKKSMSDMIEGECQAMLNDIGRKIDDGGGECVLRVDNMFGVYVLNTLWTMLSSRKHSPDDKQVKHLQHLITDLVSNVHMDGALFSHFPILRYICPQYSGYSNFVKIHQQILEFVRGEVEECKRSFDSLDHRSLIDSYLDTLKSPDTKTSFSEDQLLAISLDLFMAGTETSAKALAFAFLYLTLNPDIQTRAQEEIDAVLGRHRLPTLEDRSRLKYVECVVLESIRMFADLGFSLPYRTLKDTHLNGYFIPKDTIIIGSLRGVLMDESSGWTNPEAFQPERFIKDGRVQIPENYIPFGLGKRRCLGETLAKANVFLFVAGLLQQFNFSIVPGEPPTEETVDGMVPTPKPFVALVTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A5C7</accession>
    <name>A0A5N4A5C7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_14489</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A5C7"/>
    <dbReference type="FunCoup" id="A0A5N4A5C7">
        <property type="interactions" value="155"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A5C7"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051056">
        <property type="term" value="P:regulation of small GTPase mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14963">
        <property type="entry name" value="RHO GTPASE ACTIVATING PROTEIN 18,19-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14963:SF7">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="2">
        <location>
            <begin position="68"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0792530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="549" mass="62167" checksum="889FC510069CA0B7" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A6Z9</accession>
    <name>A0A5N4A6Z9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BAH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_12724</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052429">
        <property type="entry name" value="BAH_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043151">
        <property type="entry name" value="BAH_sf"/>
    </dbReference>
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        <property type="entry name" value="BAHCC1-like_Tudor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056841">
        <property type="entry name" value="TNRC18_BAHCC1-like_SH3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12505">
        <property type="entry name" value="PHD FINGER TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12505:SF24">
        <property type="entry name" value="PROTEIN WINGED EYE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01426">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BAHCC1-like_Tudor"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SH3_TNRC18"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAH" evidence="2">
        <location>
            <begin position="1458"/>
            <end position="1582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="1"/>
            <end position="21"/>
        </location>
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            <end position="876"/>
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            <end position="1359"/>
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        <location>
            <begin position="815"/>
            <end position="837"/>
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        <location>
            <begin position="1323"/>
            <end position="1339"/>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="1589" mass="177086" checksum="491BB39131F6419F" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A7X1</accession>
    <name>A0A5N4A7X1_PHOPY</name>
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        <recommendedName>
            <fullName evidence="2">DUF4806 domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="4" type="ORF">PPYR_00310</name>
        <name evidence="3" type="ORF">PPYR_13047</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="6778652at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032071">
        <property type="entry name" value="DUF4806"/>
    </dbReference>
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        <property type="entry name" value="SI:CH211-262H13.3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SI:CH211-262H13.3-RELATED-RELATED"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="251"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
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        </location>
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            <end position="150"/>
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            <end position="164"/>
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            <begin position="170"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF16064"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAB0793427.1"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAB0803340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="385" mass="44075" checksum="029A55AA21A567DA" modified="2020-02-26" version="1">MKKYSVVEFGDGLALVATMWLDRNNNTCIYPTHLPQNRINKAVEEQLLPSGEETWQEYPVIRIFGTSESYERGIRKLRLAETTSNIEDTDDTTNIEANNRAKKRRREMAKRKYSSDDHTETDETESLEHLPSFPDPPSLRRDLHMKKLQEKPSSSSSTPRSTPTLIHRNSPISQSFLNETPQMRATLKKSTSTASPSTMTTSEIASENEFRRLVLSKLNNIIQKIGQIEERLTSIEQWKIHATEDGSVSEEEDTELPLQNLTDLNHFEQKLKDLLFFKKMINMLKRCGGGSDVNSITTRILRQILSNSLAQQFSWAGFKGKSSFKDLRMAKLLIKTVRTMKNDVTDDLIVEAGSKWLAQAKVRACREEMRIKRKSNNELDCSNDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A9G9</accession>
    <name>A0A5N4A9G9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RNB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_13518</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the RNR ribonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="SMR" id="A0A5N4A9G9"/>
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        <property type="interactions" value="1931"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="372421at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010587">
        <property type="term" value="P:miRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041505">
        <property type="entry name" value="Dis3_CSD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022966">
        <property type="entry name" value="RNase_II/R_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050180">
        <property type="entry name" value="RNR_Ribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033771">
        <property type="entry name" value="Rrp44_CSD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355:SF9">
        <property type="entry name" value="DIS3-LIKE EXONUCLEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355">
        <property type="entry name" value="RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17849">
        <property type="entry name" value="OB_Dis3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17216">
        <property type="entry name" value="Rrp44_CSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01175">
        <property type="entry name" value="RIBONUCLEASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RNB" evidence="8">
        <location>
            <begin position="369"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="96"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="96"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0793898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="867" mass="97837" checksum="9AF087D7ADCD3068" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A9R0</accession>
    <name>A0A5N4A9R0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Beta-Casp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_13686</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. INTS9 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0794066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A9R0"/>
    <dbReference type="FunCoup" id="A0A5N4A9R0">
        <property type="interactions" value="1645"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A9R0"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032039">
        <property type="term" value="C:integrator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034472">
        <property type="term" value="P:snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022712">
        <property type="entry name" value="Beta_Casp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027074">
        <property type="entry name" value="Integrator_9su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048660">
        <property type="entry name" value="IntS9-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46094">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46094:SF1">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10996">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21382">
        <property type="entry name" value="IntS9_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16661">
        <property type="entry name" value="Lactamase_B_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01027">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-Casp" evidence="6">
        <location>
            <begin position="304"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0794066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="616" mass="68985" checksum="5B96177895F3D83A" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A9S1</accession>
    <name>A0A5N4A9S1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">G protein-coupled receptor kinase</fullName>
            <ecNumber evidence="10">2.7.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PPYR_13683</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">1611_PpyrPB1</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[G-protein-coupled receptor] + ATP = [G-protein-coupled receptor]-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12008"/>
            <dbReference type="Rhea" id="RHEA-COMP:11260"/>
            <dbReference type="Rhea" id="RHEA-COMP:11261"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43176"/>
            <dbReference type="ChEBI" id="CHEBI:68546"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="10"/>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0794063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A9S1"/>
    <dbReference type="FunCoup" id="A0A5N4A9S1">
        <property type="interactions" value="470"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A9S1"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004703">
        <property type="term" value="F:G protein-coupled receptor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01240">
        <property type="entry name" value="PH_GRK2_subgroup"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000118">
        <property type="entry name" value="G protein-coupled receptor kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000068">
        <property type="entry name" value="G protein-coupled receptor kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000239">
        <property type="entry name" value="GPCR_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24355:SF18">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24355">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR KINASE/RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00717">
        <property type="entry name" value="GPCRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RGS" evidence="13">
        <location>
            <begin position="21"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="147"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="14">
        <location>
            <begin position="411"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="11">
        <location>
            <begin position="513"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="274"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR600239-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAB0794063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="644" mass="74483" checksum="D3553990852A77A7" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-06-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AA53</accession>
    <name>A0A5N4AA53_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_13820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0794200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AA53"/>
    <dbReference type="InParanoid" id="A0A5N4AA53"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0794200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="111" mass="12283" checksum="858446D0BB197A40" modified="2020-02-26" version="1">MRGFGNSDQITKIIYVYQLPPPSPSFLEIVRGEGVYNSLPLISTYRSNAGYVFSYSAGTNAKINAGFLSRPREVLRTQHDMTNEGCGCPNFTIINFISSVYGAYNFAPKVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AB25</accession>
    <name>A0A5N4AB25_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CHK kinase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_11353</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0794514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AB25"/>
    <dbReference type="InParanoid" id="A0A5N4AB25"/>
    <dbReference type="OrthoDB" id="8250698at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015897">
        <property type="entry name" value="CHK_kinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004119">
        <property type="entry name" value="EcKL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012">
        <property type="entry name" value="PROTEIN KINASE-LIKE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012:SF30">
        <property type="entry name" value="PROTEIN KINASE-LIKE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02958">
        <property type="entry name" value="EcKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00587">
        <property type="entry name" value="CHK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="343"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="CHK kinase-like" evidence="2">
        <location>
            <begin position="131"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0794514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="412" mass="47604" checksum="6B3DDD3B51E70990" modified="2020-02-26" version="1">MSRSNDSVVLTVKQMEVLKTMLYSIGIKDYSLALSPAVEEGENCAGAVTKAVVKWTGKNGDSCTSHYILKCITSGSALENLIPLQDCFTREIYLYSKVFPQFTKMEAEHNVRFNIYPEFYTSLETTEEKMLALQDMKALGFRHHNRHQTLDYEHILLAVKNYARLHSLSYATRHQQPTLYEEFEKNTPDRFFVGFKYTGVRSVSEHRILNALKALDPVVDREIYNVFCDLKENMVSVLTNLINSKNQYQVISHIDCGLMNLLFKYDLSTNTPTDVCMIDWQHGRSESPAVDLITFIFSSSDSKTRERYHELIMEYHRCLCVSLEKLGCDGNKILPFSILENELKVYGIVGFCFAIFLIYVYSTVDQRRPDALNDDSHAEGYSFVYDLQEGSEFDRRVKEAIIDFWRLGYNFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AB43</accession>
    <name>A0A5N4AB43_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PPYR_11389</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">1611_PpyrPB1</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the teashirt C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0794550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AB43"/>
    <dbReference type="FunCoup" id="A0A5N4AB43">
        <property type="interactions" value="121"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AB43"/>
    <dbReference type="OrthoDB" id="5815793at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027008">
        <property type="entry name" value="Teashirt_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041661">
        <property type="entry name" value="ZN622/Rei1/Reh1_Znf-C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12487:SF7">
        <property type="entry name" value="PROTEIN TEASHIRT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12487">
        <property type="entry name" value="TEASHIRT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12756">
        <property type="entry name" value="zf-C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="454"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="524"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="147"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="203"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="385"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="493"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="653"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="770"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1000"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1089"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="43"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="225"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="398"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="499"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="659"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="793"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="821"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="864"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="923"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="954"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1006"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1111"/>
            <end position="1123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAB0794550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1155" mass="122758" checksum="EE635B58B304CD6D" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ABR1</accession>
    <name>A0A5N4ABR1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phorbol-ester/DAG-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_11609</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0794770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ABR1"/>
    <dbReference type="InParanoid" id="A0A5N4ABR1"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007200">
        <property type="term" value="P:phospholipase C-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20834">
        <property type="entry name" value="C1_nPKC_theta-like_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000008">
        <property type="entry name" value="Protein kinase C theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020454">
        <property type="entry name" value="DAG/PE-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22968">
        <property type="entry name" value="PROTEIN KINASE C, MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22968:SF26">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00008">
        <property type="entry name" value="DAGPEDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="4">
        <location>
            <begin position="109"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="66"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="87"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0794770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="193" mass="22195" checksum="4F2CD16E0B7A6736" modified="2020-02-26" version="1">MMFTGGSHHKKRNSSNNSNGQRKYERPARYSNFESYERERGRPRPHRQGFRSECDREVNLAANSTTSLLTNSADSDNPDDIEEFPRSRGKQITRRRGAIKHQRVHEVKGHKFLAKFFRQPTFCAFCKDFLWGFCKQGYQCQCCQTAVHKKCHEKLLGKCPGSGRESESTIVSIGTNKNGLRFQIKTKSDSLTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ACI6</accession>
    <name>A0A5N4ACI6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_11886</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0795047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ACI6"/>
    <dbReference type="FunCoup" id="A0A5N4ACI6">
        <property type="interactions" value="21"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4ACI6"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051496">
        <property type="term" value="P:positive regulation of stress fiber assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.900.10:FF:000003">
        <property type="entry name" value="Rho guanine nucleotide exchange factor 10 like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039919">
        <property type="entry name" value="ARHGEF10/ARHGEF17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12877">
        <property type="entry name" value="RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12877:SF7">
        <property type="entry name" value="RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 10-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19057">
        <property type="entry name" value="PH_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19056">
        <property type="entry name" value="WD40_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="4">
        <location>
            <begin position="192"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1192"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="359"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1202"/>
            <end position="1212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0795047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1275" mass="142351" checksum="616DA96D3EB34A8C" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AFE5</accession>
    <name>A0A5N4AFE5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable DNA replication complex GINS protein PSF2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">GINS complex subunit 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PPYR_10092</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GINS2/PSF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AFE5"/>
    <dbReference type="FunCoup" id="A0A5N4AFE5">
        <property type="interactions" value="1410"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AFE5"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071162">
        <property type="term" value="C:CMG complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11712">
        <property type="entry name" value="GINS_A_psf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21694">
        <property type="entry name" value="GINS_B_Psf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23817">
        <property type="entry name" value="RWD-RWDD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1020:FF:000001">
        <property type="entry name" value="DNA replication complex GINS protein PSF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.5.50:FF:000001">
        <property type="entry name" value="DNA replication complex GINS protein PSF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021151">
        <property type="entry name" value="GINS_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056784">
        <property type="entry name" value="PSF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042770">
        <property type="entry name" value="RWDD4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21275">
        <property type="entry name" value="RWD DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21275:SF1">
        <property type="entry name" value="RWD DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25005">
        <property type="entry name" value="PSF2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05916">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00591">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160059">
        <property type="entry name" value="PriA/YqbF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RWD" evidence="7">
        <location>
            <begin position="194"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00068356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0796031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="378" mass="43369" checksum="A5F4D494B701FAB2" modified="2020-02-26" version="1">MNPEEVEFLGEKQLISIIPTFNSSTIHLVSGDIGPFRASLPVNVPLWVAVNLKQQRKCKIQPPDWMDVEQLELLKEAEKASRNFVKMPSEHYMIEGKLLLSIATDDIARADEVRTIIKDIWDIRMAKLRSSVNTLITGKSYGNVDNLTIMEINSMRPLIPHAMDQIHRMKMERPRFSTPSQSTSLGLLNSSTDEEREALLSIYEGDTAFKQVSNTVFQYKYGEPDSPRSLLLEIIWGENYPTEKPDVNMDTFYNRHINASLKQRVKDMVLGEAEQYLGMSMTYSLFEYVKEKFDDFVKELANAEIVTDKVEELTIGDQVDDNKKKCLKKEQLTKAQKRRQWDKVGDKGERPRGWDWVDIVKHLSQTGSKEDQVSASTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AFQ2</accession>
    <name>A0A5N4AFQ2_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Prefoldin subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_10202</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AFQ2"/>
    <dbReference type="FunCoup" id="A0A5N4AFQ2">
        <property type="interactions" value="71"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AFQ2"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd22860">
        <property type="entry name" value="PDRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030482">
        <property type="entry name" value="PDRG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21162">
        <property type="entry name" value="P53 AND DNA DAMAGE-REGULATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21162:SF0">
        <property type="entry name" value="P53 AND DNA DAMAGE-REGULATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0796141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="135" mass="15264" checksum="CA26964BA43E0EF1" modified="2020-02-26" version="1">MTSPPPDVTKTLTYLLEVETVAQDILTLKDTKLELAHTLSKLQESLRAFQASQEKKSFIKVGSIFIEYPTGHCEQLVRKEIENVKEQYEVTSKELKDKLSKKRDIEHEPKIEGIGLRPLSHTEAIGLLKGFGLDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-09-13" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AG49</accession>
    <name>A0A5N4AG49_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Selenium-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_10366</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the selenium-binding protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AG49"/>
    <dbReference type="InParanoid" id="A0A5N4AG49"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008430">
        <property type="term" value="F:selenium binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008826">
        <property type="entry name" value="Se-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23300">
        <property type="entry name" value="METHANETHIOL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23300:SF0">
        <property type="entry name" value="METHANETHIOL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05694">
        <property type="entry name" value="SBP56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0711">Selenium</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0796305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="146" mass="16177" checksum="E549EB3CEC2BF178" modified="2020-02-26" version="1">MAMLDNTISLIVRTLNSWVEHSWGGSLVNDGPVTILKDEDSQPNPLCLKGKRMHGGPQMLQLSLDGTRLYVSSSLYSSWDRQFYPDMVEKGGYLVKLDVNVATGGITLDEDFLVEFDGEPDGPLLPHEMRYPGGDATSDIWLVDDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AJ02</accession>
    <name>A0A5N4AJ02_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PPYR_08329</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AJ02"/>
    <dbReference type="InParanoid" id="A0A5N4AJ02"/>
    <dbReference type="OrthoDB" id="6772002at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050578">
        <property type="entry name" value="MARVEL-CKLF_proteins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22776:SF49">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22776">
        <property type="entry name" value="MARVEL-CONTAINING POTENTIAL LIPID RAFT-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51225">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="7">
        <location>
            <begin position="12"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0797335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="135" mass="14708" checksum="A6C52905325ED617" modified="2020-02-26" version="1">MATENLILGVDYFKTGSGISKIVEEVANFFAIVCVAVGGASPTGDAFLVCAFFAFISSAALLILYVTQLAARFDIPWYKVEFGLCILWIVFYIIVSSLTLIIWTPAYTAGAIFGFFAVFTYGADAFLKVKATYFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AJG0</accession>
    <name>A0A5N4AJG0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PITH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_08420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PITHD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AJG0"/>
    <dbReference type="FunCoup" id="A0A5N4AJG0">
        <property type="interactions" value="2119"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AJG0"/>
    <dbReference type="OrthoDB" id="2635at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045654">
        <property type="term" value="P:positive regulation of megakaryocyte differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060255">
        <property type="term" value="P:regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080090">
        <property type="term" value="P:regulation of primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.470:FF:000002">
        <property type="entry name" value="PITH domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.470">
        <property type="entry name" value="PITH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045099">
        <property type="entry name" value="PITH1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010400">
        <property type="entry name" value="PITH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037047">
        <property type="entry name" value="PITH_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12175">
        <property type="entry name" value="AD039 HT014 THIOREDOXIN FAMILY TRP26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12175:SF1">
        <property type="entry name" value="PITH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06201">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51532">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PITH" evidence="2">
        <location>
            <begin position="16"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0797426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="207" mass="23680" checksum="617BE3E06BB8EE1C" modified="2020-02-26" version="1">MAPHGHHSCEGDKNHDDTPEMGVQYSLYAKIDKENLECLNELTEGSGKLVFKQWEDRLNFVEYVESDADEELLFNIPFTGNIKLKGIIVVGEDSDSHPSKMRLYKNRPHMTFDDVRIPADQEFDLHTDSSGTLEYATKIVLFSSVHHLSIHFPSNFGGDQTRVYYIGLKGEFTEAHRHGVTICTYEARPNVYDHKNPLEDNVSHQIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ALH2</accession>
    <name>A0A5N4ALH2_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase C1A papain C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PPYR_05111</name>
        <name evidence="5" type="ORF">PPYR_09061</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ALH2"/>
    <dbReference type="InParanoid" id="A0A5N4ALH2"/>
    <dbReference type="OrthoDB" id="190265at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000332">
        <property type="entry name" value="Cathepsin L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="4">
        <location>
            <begin position="215"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="137"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="152"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="210"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0798068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0802925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="436" mass="46928" checksum="A3B42EC9C54085C1" modified="2020-02-26" version="1">MPYLQHFKMKKSILLVVVTIVVAATLSEAVQFGLFNRPSHQSTTTSKPQPRGGLLGLNILKPVTSILDAVGHTVGAILNLLVGGLRYKPYKRITTTPMPTISVEITPPHIVSIEINTPPPTAHVVVSLSTKPSLPVAPPKITTPTSTLAAITESTTQSTVTSEKPTEPTTTESTTQPSPTPSQSPTTPTTVEVTTASTTHAPTTTTEASITEKGKPGNVDWRRLNCSSPITFQGKCRGSFAFAVTAAIEAQMCYKTGQYTVLSAQNLIDCTMVAPFENAGCDGGALEPTFDYVVNVGINSEEDYPYTASISKCKYNQEKSVGRINDYMSIDEGDEETMEYILNNVGPIAVGIDATHKSFADYRGGVYYEPNCKSDIESLNHAVLLVGYGVEPDGTKYWLIRNSYGTEWGDKGYGKIARTATNHCGINTYAVYPVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ALY0</accession>
    <name>A0A5N4ALY0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_09317</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ALY0"/>
    <dbReference type="InParanoid" id="A0A5N4ALY0"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009247">
        <property type="term" value="P:glycolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051276">
        <property type="entry name" value="Saccharopine_DH-like_oxidrdct"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12286">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12286:SF5">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0798324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="821" mass="94937" checksum="E339CA511F06614B" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AML2</accession>
    <name>A0A5N4AML2_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DUF4771 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_09550</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AML2"/>
    <dbReference type="InParanoid" id="A0A5N4AML2"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031935">
        <property type="entry name" value="DUF4770"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031936">
        <property type="entry name" value="DUF4771"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41967">
        <property type="entry name" value="FI19406P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41967:SF6">
        <property type="entry name" value="FI19406P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15994">
        <property type="entry name" value="DUF4770"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15995">
        <property type="entry name" value="DUF4771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4770" evidence="3">
        <location>
            <begin position="190"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4771" evidence="4">
        <location>
            <begin position="799"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="257"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="109"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF15994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF15995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0798557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="961" mass="110467" checksum="262F2C1380EDFD63" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AN98</accession>
    <name>A0A5N4AN98_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_06664</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0798784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AN98"/>
    <dbReference type="FunCoup" id="A0A5N4AN98">
        <property type="interactions" value="994"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AN98"/>
    <dbReference type="OrthoDB" id="4869960at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045151">
        <property type="entry name" value="DCAF8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15574:SF21">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15574">
        <property type="entry name" value="WD REPEAT DOMAIN-CONTAINING FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="202"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="98"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="581"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="12"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="64"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="587"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="607"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0798784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="616" mass="67992" checksum="925F14251BB45BE6" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4APU5</accession>
    <name>A0A5N4APU5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_07227</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4APU5"/>
    <dbReference type="FunCoup" id="A0A5N4APU5">
        <property type="interactions" value="5"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4APU5"/>
    <dbReference type="OrthoDB" id="19493at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048066">
        <property type="term" value="P:developmental pigmentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056499">
        <property type="entry name" value="Beta-prop_HPS5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056446">
        <property type="entry name" value="TPR_HPS5_insects"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23287:SF18">
        <property type="entry name" value="BLOC-2 COMPLEX MEMBER HPS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23287">
        <property type="entry name" value="RUBY-EYE2-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23756">
        <property type="entry name" value="Beta-prop_HPS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23757">
        <property type="entry name" value="TPR_HPS5_insect"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HPS5-like beta-propeller" evidence="1">
        <location>
            <begin position="13"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="HPS5 TPR" evidence="2">
        <location>
            <begin position="558"/>
            <end position="735"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0799347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="891" mass="102381" checksum="8D2A47F7AEB5DFBB" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AQ76</accession>
    <name>A0A5N4AQ76_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Sensory neuron membrane protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PPYR_07360</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CD36 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AQ76"/>
    <dbReference type="InParanoid" id="A0A5N4AQ76"/>
    <dbReference type="OrthoDB" id="10024078at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005044">
        <property type="term" value="F:scavenger receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007608">
        <property type="term" value="P:sensory perception of smell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002159">
        <property type="entry name" value="CD36_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11923">
        <property type="entry name" value="SCAVENGER RECEPTOR CLASS B TYPE-1 SR-B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11923:SF69">
        <property type="entry name" value="SENSORY NEURON MEMBRANE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01130">
        <property type="entry name" value="CD36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01609">
        <property type="entry name" value="CD36FAMILY"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0552">Olfaction</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="497"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAB0799480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="552" mass="62094" checksum="60F490899C9FD58A" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-09-13" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AR06</accession>
    <name>A0A5N4AR06_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Attacin C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_07640</name>
        <name evidence="2" type="ORF">PPYR_09912</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0795851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AR06"/>
    <dbReference type="InParanoid" id="A0A5N4AR06"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036147765" description="Attacin C-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0795851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0799760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="199" mass="20138" checksum="33E1430F02590224" modified="2020-02-26" version="1">MVKHVFSLFLVVALVSQSMAQFFGGGGFLPSGGIGGMGGYKYGPAWGSVSSSYDGRRLGPVDVGGGAHFKLPNDGFAGARASVQPGVGGTSSLYGKVNIFDTPTHRLDVQGHHDRFLNRDLKPVGPAINEIGANYKHVGGATAHIGASKVGSGPIQGSLGASVPLLSTPQGGINLGVQGVAGQGMKPQGQIGVVGEIKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AR08</accession>
    <name>A0A5N4AR08_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">SH3 and multiple ankyrin repeat domains protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_07662</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
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        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
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        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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            <end position="11"/>
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        <location>
            <begin position="1605"/>
            <end position="1614"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="PROSITE" id="PS50106"/>
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    </evidence>
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    </evidence>
    <sequence length="1734" mass="192067" checksum="CD253E0DF6EED063" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ARB5</accession>
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        <recommendedName>
            <fullName evidence="5">SKI/SNO/DAC domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="6" type="ORF">PPYR_07751</name>
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    <organism evidence="6 7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
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        <lineage>
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            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
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                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
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            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">1611_PpyrPB1</strain>
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        <subcellularLocation>
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    <comment type="similarity">
        <text evidence="3">Belongs to the DACH/dachshund family.</text>
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    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Dachshund homolog 1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Ski"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Putative DNA-binding domain"/>
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        <location>
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            <end position="223"/>
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    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="70"/>
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    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="34"/>
            <end position="44"/>
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        <location>
            <begin position="358"/>
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        <location>
            <begin position="380"/>
            <end position="398"/>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="429"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0799871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="547" mass="58824" checksum="7A5901EC2E66024A" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AS19</accession>
    <name>A0A5N4AS19_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PPYR_08007</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0800127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AS19"/>
    <dbReference type="OrthoDB" id="6515930at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd01450">
        <property type="entry name" value="vWFA_subfamily_ECM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.50.10:FF:000018">
        <property type="entry name" value="Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.10">
        <property type="entry name" value="Tumor Necrosis Factor Receptor, subunit A, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003410">
        <property type="entry name" value="HYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001759">
        <property type="entry name" value="PTX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011641">
        <property type="entry name" value="Tyr-kin_ephrin_A/B_rcpt-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46393:SF7">
        <property type="entry name" value="COMPLEMENT C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46393">
        <property type="entry name" value="SUSHI DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07699">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02494">
        <property type="entry name" value="HYR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00354">
        <property type="entry name" value="Pentaxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00895">
        <property type="entry name" value="PENTAXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00453">
        <property type="entry name" value="VWFADOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM01411">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00159">
        <property type="entry name" value="PTX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50825">
        <property type="entry name" value="HYR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51828">
        <property type="entry name" value="PTX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8" id="KW-0732">Signal</keyword>
    <keyword evidence="1 7" id="KW-0768">Sushi</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024424862" description="Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1" evidence="8">
        <location>
            <begin position="19"/>
            <end position="1894"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="10">
        <location>
            <begin position="80"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="12">
        <location>
            <begin position="369"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="12">
        <location>
            <begin position="443"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="12">
        <location>
            <begin position="501"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="11">
        <location>
            <begin position="565"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="11">
        <location>
            <begin position="650"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="1128"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="1167"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="1240"/>
            <end position="1282"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="1284"/>
            <end position="1320"/>
        </location>
    </feature>
    <feature type="domain" description="Pentraxin (PTX)" evidence="13">
        <location>
            <begin position="1325"/>
            <end position="1525"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="12">
        <location>
            <begin position="1526"/>
            <end position="1583"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="12">
        <location>
            <begin position="1584"/>
            <end position="1641"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="12">
        <location>
            <begin position="1642"/>
            <end position="1710"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="12">
        <location>
            <begin position="1716"/>
            <end position="1781"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="12">
        <location>
            <begin position="1782"/>
            <end position="1841"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="371"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="400"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="471"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="1155"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="1171"/>
            <end position="1181"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="1193"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="1272"/>
            <end position="1281"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="1310"/>
            <end position="1319"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="1612"/>
            <end position="1639"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="1681"/>
            <end position="1708"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="1752"/>
            <end position="1779"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="1812"/>
            <end position="1839"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAB0800127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1894" mass="209528" checksum="F951031821CB1D30" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AU33</accession>
    <name>A0A5N4AU33_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PPYR_06576</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000004">
        <property type="protein sequence ID" value="KAB0800837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AU33"/>
    <dbReference type="InParanoid" id="A0A5N4AU33"/>
    <dbReference type="OrthoDB" id="6758319at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021896">
        <property type="entry name" value="THAP9-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048366">
        <property type="entry name" value="TNP-like_GBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048365">
        <property type="entry name" value="TNP-like_RNaseH_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21788">
        <property type="entry name" value="TNP-like_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21787">
        <property type="entry name" value="TNP-like_RNaseH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12017">
        <property type="entry name" value="Tnp_P_element"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00692">
        <property type="entry name" value="DM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="677"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="domain" description="THAP-type" evidence="7">
        <location>
            <begin position="6"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0800837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="700" mass="81532" checksum="17352BC6013E4254" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AUL8</accession>
    <name>A0A5N4AUL8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nuclear protein MDM1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PPYR_05426</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Microtubule-binding protein that negatively regulates centriole duplication. Binds to and stabilizes microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
            <location evidence="1">Centriole</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MDM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000003">
        <property type="protein sequence ID" value="KAB0801072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AUL8"/>
    <dbReference type="FunCoup" id="A0A5N4AUL8">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AUL8"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046600">
        <property type="term" value="P:negative regulation of centriole replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029136">
        <property type="entry name" value="MDM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32078">
        <property type="entry name" value="NUCLEAR PROTEIN MDM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32078:SF1">
        <property type="entry name" value="NUCLEAR PROTEIN MDM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15501">
        <property type="entry name" value="MDM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="98"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="357"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="549"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="643"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="103"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="115"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="147"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="368"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="396"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="422"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="441"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="476"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="550"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="561"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="645"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="670"/>
            <end position="679"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0801072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="689" mass="78175" checksum="026301BB0725E564" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AUP5</accession>
    <name>A0A5N4AUP5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Fork-head domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PPYR_05401</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000003">
        <property type="protein sequence ID" value="KAB0801047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AUP5"/>
    <dbReference type="InParanoid" id="A0A5N4AUP5"/>
    <dbReference type="OrthoDB" id="5830876at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.340:FF:000005">
        <property type="entry name" value="Forkhead box P1, isoform CRA_f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000010">
        <property type="entry name" value="Forkhead box P2 isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050998">
        <property type="entry name" value="FOXP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032354">
        <property type="entry name" value="FOXP-CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45796">
        <property type="entry name" value="FORKHEAD BOX P, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45796:SF4">
        <property type="entry name" value="FORKHEAD BOX P, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16159">
        <property type="entry name" value="FOXP-CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Fork-head" evidence="13">
        <location>
            <begin position="534"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="10">
        <location>
            <begin position="534"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="117"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="617"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="216"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="117"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="163"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="641"/>
            <end position="651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAB0801047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="785" mass="88058" checksum="85F12FE95AB6EE18" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AV86</accession>
    <name>A0A5N4AV86_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">receptor protein-tyrosine kinase</fullName>
            <ecNumber evidence="2">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PPYR_05527</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">1611_PpyrPB1</strain>
            <tissue evidence="19">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="2"/>
    <dbReference type="EMBL" id="VVIM01000003">
        <property type="protein sequence ID" value="KAB0801173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AV86"/>
    <dbReference type="InParanoid" id="A0A5N4AV86"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000087">
        <property type="entry name" value="Tyrosine-protein kinase receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001941">
        <property type="entry name" value="Tyrosine-protein kinase receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.20.20:FF:000001">
        <property type="entry name" value="Tyrosine-protein kinase receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.220.10">
        <property type="entry name" value="Hormone Receptor, Insulin-like Growth Factor Receptor 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.20.20">
        <property type="entry name" value="Receptor L-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050449">
        <property type="entry name" value="Ephrin_rcpt_TKs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006211">
        <property type="entry name" value="Furin-like_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000494">
        <property type="entry name" value="Rcpt_L-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036941">
        <property type="entry name" value="Rcpt_L-dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46877">
        <property type="entry name" value="EPH RECEPTOR A5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46877:SF14">
        <property type="entry name" value="RECEPTOR PROTEIN-TYROSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00757">
        <property type="entry name" value="Furin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01030">
        <property type="entry name" value="Recep_L_domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="991"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="18">
        <location>
            <begin position="364"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="17">
        <location>
            <begin position="538"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="17">
        <location>
            <begin position="656"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="17">
        <location>
            <begin position="885"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="1084"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAB0801173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1154" mass="130815" checksum="FDD6943A3359C48F" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AVE3</accession>
    <name>A0A5N4AVE3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PPYR_05696</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000003">
        <property type="protein sequence ID" value="KAB0801342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AVE3"/>
    <dbReference type="InParanoid" id="A0A5N4AVE3"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16563">
        <property type="entry name" value="RING-HC_RNF220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052443">
        <property type="entry name" value="E3_ubiq-ligase_RNF220-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031824">
        <property type="entry name" value="RNF220_mid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040178">
        <property type="entry name" value="RNF220_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13459">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF220 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13459:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF220 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15926">
        <property type="entry name" value="RNF220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="1 3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="534"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="127"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="297"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="429"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="150"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="169"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="452"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="463"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="487"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0801342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="586" mass="64193" checksum="D5AF35F35BB6A2B3" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AW90</accession>
    <name>A0A5N4AW90_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein ARV</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PPYR_03821</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Mediator of sterol homeostasis involved in sterol uptake, trafficking and distribution into membranes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ARV1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0801635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AW90"/>
    <dbReference type="InParanoid" id="A0A5N4AW90"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019902">
        <property type="term" value="F:phosphatase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032366">
        <property type="term" value="P:intracellular sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097036">
        <property type="term" value="P:regulation of plasma membrane sterol distribution"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016125">
        <property type="term" value="P:sterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007290">
        <property type="entry name" value="Arv1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026142">
        <property type="entry name" value="Pro_pase_1_reg_su_36"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21055">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21055:SF3">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04161">
        <property type="entry name" value="Arv1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14895">
        <property type="entry name" value="PPPI_inhib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 10" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0801635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="656" mass="76583" checksum="D40D42D32AD82818" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AWG4</accession>
    <name>A0A5N4AWG4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NLE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PPYR_03865</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the NLE1/RSA4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0801679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AWG4"/>
    <dbReference type="FunCoup" id="A0A5N4AWG4">
        <property type="interactions" value="1336"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AWG4"/>
    <dbReference type="OrthoDB" id="10267436at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000092">
        <property type="entry name" value="notchless protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012972">
        <property type="entry name" value="NLE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF0">
        <property type="entry name" value="NOTCHLESS PROTEIN HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08154">
        <property type="entry name" value="NLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="NLE" evidence="7">
        <location>
            <begin position="15"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="108"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="150"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="193"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="240"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="360"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="402"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="444"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00061016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0801679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="477" mass="53588" checksum="D07FBA4AE41FCB1A" modified="2020-02-26" version="1">MSEMEVEEKEERKRILCRFKSEAGEELGEMMDLPLECGLEELTLICNAILQNEERTPFLFFINDVEITQDLKSTVDLSTINTENVVDIVYQQQAIFRVRPVTRCTSSMPGHAEAVISVSFSPDGKHLASGSGDTTVRFWDLHTQNPYYSCHGHRNWVLCISWSPNSKKLASACKNGQIIIWDPDTGTQLGKTMIGHKQWVTSLSWEPYHKNPECRLLASSSKDGDVRIWDTNLCQTVRILSGHTKSVTVVKWGGSGLLYTASQDRTVRVWRTSDGVLCRVLEGHAHWVNTLALSSDYILKIGPFDPANFTKGATVNSQQFAEERYNNVIKAYGERLVSGSDDFTLFLWDPEHDKKPRARLTGHQQLVNDVKFSPDGRILASASFDKSIKLWDGKSGQFICTLRGHVQAVYMIAFSVDSRLMVSGSADSTLKLWNLRTKKLEFDLPGHGDEVYAVDWSTNGAMVASGGKDKVLKLWQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AX14</accession>
    <name>A0A5N4AX14_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_04043</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0801857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AX14"/>
    <dbReference type="InParanoid" id="A0A5N4AX14"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="3">
        <location>
            <begin position="2"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0801857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="152" mass="17392" checksum="2C46941B38368500" modified="2020-02-26" version="1">MDIYVGMPGRVHDARVLRTSPVYGHLVNNNTIMPQNCHILGDSAYPLMENLLQWALKRRPNTAVIERAFGQLKGKFRRLKYLDIAEPDFATEIITAACVLHNFTLMWGEEMHDNEAIIEGENNHQEADDNDVVADHQNGVEKRNFIVNISRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AX52</accession>
    <name>A0A5N4AX52_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4200 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_04110</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0801924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AX52"/>
    <dbReference type="InParanoid" id="A0A5N4AX52"/>
    <dbReference type="OrthoDB" id="10264063at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051147">
        <property type="entry name" value="CFAP_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025252">
        <property type="entry name" value="DUF4200"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21683:SF3">
        <property type="entry name" value="CILIA AND FLAGELLA ASSOCIATED PROTEIN 100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21683">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 42 LIKE-2-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13863">
        <property type="entry name" value="DUF4200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4200" evidence="3">
        <location>
            <begin position="173"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="512"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="521"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0801924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="570" mass="66692" checksum="9CB1A49AC4651F9D" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AXA2</accession>
    <name>A0A5N4AXA2_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_04074</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0801888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AXA2"/>
    <dbReference type="InParanoid" id="A0A5N4AXA2"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006616">
        <property type="entry name" value="DM9_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31649">
        <property type="entry name" value="AGAP009604-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31649:SF10">
        <property type="entry name" value="IP19903P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11901">
        <property type="entry name" value="DM9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024339137" evidence="1">
        <location>
            <begin position="20"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0801888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="198" mass="23209" checksum="EA1AE5728A1DD3B3" modified="2020-02-26" version="1">MKLIIISITFLSLSLLARGSKHHGPNYKDHIGFYWEDFEKTRIMKGVVGGKDARNRHTYIGLTKHLEGNKELLVPGVIYPWDLEPYMVYEWNERPKKIIADFKMLYTNYPDHMTWIKTNTSDIRQLVREKELISAGYDTRHRKYYIGRIPMNDNLILGKIIISNNGDNDGFFAFSKSGYHHAMEFEVLVHELKLNSIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AXB0</accession>
    <name>A0A5N4AXB0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transgelin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_04188</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the calponin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AXB0"/>
    <dbReference type="FunCoup" id="A0A5N4AXB0">
        <property type="interactions" value="324"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AXB0"/>
    <dbReference type="OrthoDB" id="21595at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000075">
        <property type="entry name" value="Transgelin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050606">
        <property type="entry name" value="Calponin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000557">
        <property type="entry name" value="Calponin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003096">
        <property type="entry name" value="SM22_calponin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47385">
        <property type="entry name" value="CALPONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47385:SF14">
        <property type="entry name" value="TRANSGELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00402">
        <property type="entry name" value="Calponin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00888">
        <property type="entry name" value="SM22CALPONIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01052">
        <property type="entry name" value="CALPONIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51122">
        <property type="entry name" value="CALPONIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="3">
        <location>
            <begin position="25"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0802002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="188" mass="20855" checksum="C1AE9724CE7F6F6F" modified="2020-02-26" version="1">MANNRATKSGFAAEAQRKINAKYSDELAQESLEWVKIILGEEFDVSGDMDNFYEVLRDGQVLCRLVNNLKPGVVKKVNNSQMAFKCMENINAFLEAVKDLGVPAQETFQTVDLWERQNLNSVVICLQSLGRKAGNYGKPSIGPKEADKNERHFSEEKLKAGQTIIGLQMGSNKGATQSGIIMGNTRHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AYG6</accession>
    <name>A0A5N4AYG6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PPYR_04587</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">1611_PpyrPB1</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Microsome membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 15">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AYG6"/>
    <dbReference type="InParanoid" id="A0A5N4AYG6"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11056">
        <property type="entry name" value="CYP6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000182">
        <property type="entry name" value="Cytochrome P450 3A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050476">
        <property type="entry name" value="Insect_CytP450_Detox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292:SF84">
        <property type="entry name" value="CYTOCHROME P450 28A5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 14 15" id="KW-0349">Heme</keyword>
    <keyword evidence="11 14 15" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0492">Microsome</keyword>
    <keyword evidence="12 15" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="10 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="14">
        <location>
            <position position="402"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAB0802401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="461" mass="52800" checksum="81E76B7D3A8DA0CB" modified="2020-02-26" version="1">MGESLTGSKSLGQICAEIYNAFPNHTYVGFYKSRTPGIVVRDYELIKDILIKDFKKFHDNDFYIDEKVDLIMGKNVFTLRGEQWKQTKSQLSRCFTSKKLKTMFPLMDEVGKAMITYLNNRQENNQLDGFDAKELASAFAVDLIASCTFGVAGHSFDSKKGELKKMVGEMFPQSTIIALKHVIFFVLPSLSSFIEVRVFPEKLTRYVRNMVTKTIRYRELNSIVYGDFLDIIREPIKDSRPFTEDDLTAHAGGFFGDGVETTSIATSYILYELAVHTDVQETLRQQIDDILSKHENKFDYDNILELEYLDNVLQETLRLHPPFPYMAKICTETIQWPSPLGLGKGPNVTLTKNMPIFIPVYGIQRDQKFYSDPNQFRPERFSTENKGINRPFLSFGSGPRRCLGERLGHIQVKIAIAYIVANFKITLNKKTILPLKIDPKYFLMAPKGGIHVNIVKRDEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AZJ7</accession>
    <name>A0A5N4AZJ7_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_04766</name>
        <name evidence="2" type="ORF">PPYR_09806</name>
        <name evidence="3" type="ORF">PPYR_10672</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0795745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AZJ7"/>
    <dbReference type="InParanoid" id="A0A5N4AZJ7"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1820">
        <property type="entry name" value="L1 transposable element, RRM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004244">
        <property type="entry name" value="Transposase_22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11505">
        <property type="entry name" value="L1 TRANSPOSABLE ELEMENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="51"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0795745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0796611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0802580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="222" mass="25186" checksum="4454C4F93C5E8348" modified="2020-02-26" version="1">MVLTQSQTQDVQGLLENFVTSNDVISQIAASVAKIVEVNLQKTFANQNQIIAQMQGEISQLKVENGALSSENKALKAELDVLQQYSRRNNVRILGIKETVNENLDEIVINLFKSKLNVNLEIDHIDRMHRVGKPTSGSSRQIIVKFTSYRYRKLVFDNKKLLKGTGIRIAEDLTKTRLMLLKEAISRYPRENVWSFDGNIWVNTGGKKILIRSVAEFPKSVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B017</accession>
    <name>A0A5N4B017_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Programmed cell death protein 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_05121</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B017"/>
    <dbReference type="InParanoid" id="A0A5N4B017"/>
    <dbReference type="OrthoDB" id="2289628at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005689">
        <property type="term" value="C:U12-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052831">
        <property type="entry name" value="Apoptosis_promoter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031974">
        <property type="entry name" value="PDCD7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48190">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48190:SF2">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16021">
        <property type="entry name" value="PDCD7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0802935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="412" mass="47795" checksum="F3E78D8C12F7781F" modified="2020-02-26" version="1">MDYYNNSNTFSASHSLTHTQNYNYPSYSVSDPRLSYAYHNTVPIHQTSNDSNSLQLYDLSLPANVIETKSDDELWIETWLSKIGKIQINLNSTIEIKPTRSTVYKTNNIQIHSVRNSLRNCVQILNNLQSLQEYLKKNASTMSSAEWTKKTTEIGLIKEQFSKHMFQFESQETMSKILKAVEQRKKKRNCQRRRRQQRSIDSAKQREEIDKAHKEVDRWLENMKDEVERAKMEELMKKDADCVLAEVTKKKSDARKTLSLIASLVKLRQVREHAAKQRGEKVSLEDHNAFEKVTNHLTKIWDSALEVYGKEEKTLQVMLMQTATEDNNSARIAKERNIMHEWESAFFGPKTILAPSYFNLAVAEKDLDTFIAIRKSWDTFLSAEDESVSNIPVGWVLPNSNPNGDWAKYRNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B0T3</accession>
    <name>A0A5N4B0T3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Transcriptional regulator ATRX</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PPYR_00172</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B0T3"/>
    <dbReference type="FunCoup" id="A0A5N4B0T3">
        <property type="interactions" value="542"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4B0T3"/>
    <dbReference type="OrthoDB" id="9900844at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.850">
        <property type="entry name" value="SWI2/SNF2 ATPases, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044574">
        <property type="entry name" value="ARIP4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45797">
        <property type="entry name" value="RAD54-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45797:SF3">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR ATRX HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="170"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="570"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="488"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="491"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="503"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="518"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="531"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAB0803202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="883" mass="102084" checksum="58CBCB89BA25CDCA" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B155</accession>
    <name>A0A5N4B155_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PiggyBac transposable element-derived protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_00218</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B155"/>
    <dbReference type="InParanoid" id="A0A5N4B155"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599:SF6">
        <property type="entry name" value="DUAL SPECIFICITY PHOSPHATASE 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="2">
        <location>
            <begin position="67"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="2">
        <location>
            <begin position="131"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0803248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="281" mass="32194" checksum="21A53ABD319B18E9" modified="2020-02-26" version="1">MSYYEKEQRHLLELWNELEEEVVGGSDDEEDVQEDFGETSNHESEFELSEDEELSEQNIKSGLLLYFPDSVLEKIVECTNRYIAKIRPRYSRARDAADTDVVEIKAVLGLLYLAGVQRSSHINLRDLWMQAPISGTGRNVTCDNWFTSIPLALELLQKHNLTLVGTLRKNKREIPEFFSAKIKERRINTSMFGFTKDMTLVSYKPKQNKIVLLLSTMHYADEIDQETGDACKPAMITFYNSTKGGVDELKGNYSVSRKSSRWPLTIFFSMLNIAGINSQII</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B1L1</accession>
    <name>A0A5N4B1L1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transposase Helix-turn-helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_00434</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B1L1"/>
    <dbReference type="InParanoid" id="A0A5N4B1L1"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0803464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="181" mass="21715" checksum="E15A6013279C4EA5" modified="2020-02-26" version="1">MFTDSESDSETITLYLLNNRRKRKRKMWVRPMFLQREQWGEFYHLVPQLKADSAQFFEYYRMSPESYELLVSIVKPLVTIYKTNFREPIPFEEWLTVTLRYLATGESFHSLSFRFRISHNRMSVMINILLSQIYNGLKEKYLKFPDTAKFLEIAEGFKNKKKFPNCLGAIEGETYPYKETI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B1T8</accession>
    <name>A0A5N4B1T8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Metalloendopeptidase</fullName>
            <ecNumber evidence="2">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_00539</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1 2">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="2"/>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B1T8"/>
    <dbReference type="InParanoid" id="A0A5N4B1T8"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04280">
        <property type="entry name" value="ZnMc_astacin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034035">
        <property type="entry name" value="Astacin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF850">
        <property type="entry name" value="METALLOENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 2" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 2" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M12A" evidence="3">
        <location>
            <begin position="1"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0803569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="176" mass="19686" checksum="3927FE8537A6135A" modified="2020-02-26" version="1">MGSFARFSDGRMAKSVTPFLHHTINPKLILSEVPSQLQYSNDHGCESAVGRWGGQQILNFQSSCFDRGTMLHEMLHAVGFRHQHNSPDRDDYITINRENLKDGSTTVLKKYTSSEVTNFGLPYDYCSVSHYSMFASSKNGKPTIVPKFPTTCELGTATDLSPIDKKKINLMYPCGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B2X8</accession>
    <name>A0A5N4B2X8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Exocyst complex component 5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Exocyst complex component Sec10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_00873</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B2X8"/>
    <dbReference type="FunCoup" id="A0A5N4B2X8">
        <property type="interactions" value="1895"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4B2X8"/>
    <dbReference type="OrthoDB" id="125856at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009976">
        <property type="entry name" value="Sec10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048627">
        <property type="entry name" value="Sec10_HB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048625">
        <property type="entry name" value="Sec10_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12100:SF0">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12100">
        <property type="entry name" value="SEC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07393">
        <property type="entry name" value="Sec10_HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20667">
        <property type="entry name" value="Sec10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component Sec10 N-terminal" evidence="8">
        <location>
            <begin position="42"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Exocyst complex component Sec10-like alpha-helical bundle" evidence="7">
        <location>
            <begin position="160"/>
            <end position="706"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0803903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="711" mass="82062" checksum="3AF460D2A9F97213" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B3K0</accession>
    <name>A0A5N4B3K0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SV2A/B/C luminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_01116</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B3K0"/>
    <dbReference type="InParanoid" id="A0A5N4B3K0"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.80">
        <property type="entry name" value="E3 ubiquitin-protein ligase SopA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055415">
        <property type="entry name" value="LD_SV2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23894">
        <property type="entry name" value="LD_SV2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141571">
        <property type="entry name" value="Pentapeptide repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="SV2A/B/C luminal" evidence="2">
        <location>
            <begin position="25"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0804146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="279" mass="31577" checksum="DDCCB8A51FC0A550" modified="2020-02-26" version="1">MGISTFSYSRIRETNDLHYFSMKKYISNQNYTDVMFNSTVENVQYKECNFENVTFTHLHFNHVEFVNCMFEETEFNNVKSSITYFENSTIKDSRFIDTDLTEQHFLNCNLINNTVLSLLTDCVVDFDYNIYLNDLFKETIAWAGPMVPALLVLGFVLEATSRPPVLVLLLVLASVVSIGIFFLVNFVSTVIVEAIFKVLLICAVNVLTMVVIEGYPCHLRCTAHGMMRSVYHLASLCAIPIYGTLVHTILLFPAVTTVALALLAAMLSTRIQDNSKVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B3M3</accession>
    <name>A0A5N4B3M3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Putative nuclease HARBI1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Harbinger transposase-derived nuclease</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PPYR_01123</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Transposase-derived protein that may have nuclease activity. Does not have transposase activity.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HARBI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B3M3"/>
    <dbReference type="InParanoid" id="A0A5N4B3M3"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026103">
        <property type="entry name" value="HARBI1_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF85">
        <property type="entry name" value="GH03217P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02086">
        <property type="entry name" value="PUTNUCHARBI1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="13">
        <location>
            <begin position="109"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAB0804153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="319" mass="35840" checksum="63EB49C72A8D0678" modified="2020-02-26" version="1">MQRKTFDFILSLIGPKISENVVKPGRPSVSPETQLLLTLWILGTPDSYRSVSDRFNVGKATAVISVRRVVKALYDHVHTFIKWPIADEMETSIRVFRAVKGFPNVIGAIDGTHISITAPKNNAEAYVNRKGYHSMQLQAVCNENGMFIHCFTGYPGAVHDQRVFQNSDLPEFFRNDTQFPDDVHILGDAAYKLHKHLMVPFKDNGHLTDIQKNFNMCHSSTRMAIERAFGLLKGRMRRLLDTLPMTREDLIPKYIITCCILHNICVLKQDQFQPLAVAISNNASAVEILATREPDGGGRDVAIRKRDVIAAELPMQIGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B3Q6</accession>
    <name>A0A5N4B3Q6_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PPYR_01154</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B3Q6"/>
    <dbReference type="InParanoid" id="A0A5N4B3Q6"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF1">
        <property type="entry name" value="FI18259P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0804184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="112" mass="12243" checksum="213EF63681B66881" modified="2020-02-26" version="1">MSRILGGIGYALSPTVIWFYACTLLDVVNGTAFIVSRSMATKLVTESNMGKVNSLFGVIEALSALACTPAYSAFYRVTIEIFPGAFNILGVIVTLPAILIYIWLYIRRDVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B4E8</accession>
    <name>A0A5N4B4E8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PiggyBac transposable element-derived protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_01378</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B4E8"/>
    <dbReference type="InParanoid" id="A0A5N4B4E8"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10773:SF19">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10773">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0804408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="712" mass="82747" checksum="39B07BFDBC5877DD" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B532</accession>
    <name>A0A5N4B532_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ketoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_01672</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Putative oxidoreductase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B532"/>
    <dbReference type="FunCoup" id="A0A5N4B532">
        <property type="interactions" value="98"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4B532"/>
    <dbReference type="OrthoDB" id="5307821at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05332">
        <property type="entry name" value="11beta-HSD1_like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004825">
        <property type="entry name" value="PRK06181.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44196">
        <property type="entry name" value="DEHYDROGENASE/REDUCTASE SDR FAMILY MEMBER 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44196:SF1">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE SDR FAMILY MEMBER 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000126">
        <property type="entry name" value="11-beta-HSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="Ketoreductase" evidence="6">
        <location>
            <begin position="37"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0804702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="303" mass="33848" checksum="327AD040D9ABD521" modified="2020-02-26" version="1">MANSWRTWLSSFAMTVTLYKVFKYLFFRRNKSYFKEKVVLITGASSGIGESLAHEFYKRGCKVVLCARRRDELERVHNDLVRKYPPLTVLPIIMTMDLTNIGSLEAIVEQIIDITGHIDILINNGGVSNRGAVIETSNEVFMNIMMVNYFGTVALTKAVLPHMVNRREGHIVFMSSVQGLIAIPHRAAYAASKHAIQAFSDSLRAEIAQDNINVSVVSPGYVKTAISLNALTGSGFKHGKVDTNTDQGYSPDYVAQKTAVAILKEKNEIVIAPLLHRAVVLIRCNFPSLYFLIMQHRVKNKDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-06-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B5M0</accession>
    <name>A0A5N4B5M0_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_01872</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B5M0"/>
    <dbReference type="InParanoid" id="A0A5N4B5M0"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0804902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="203" mass="23687" checksum="463A5C603D8E8FD2" modified="2020-02-26" version="1">MEMDSDASFSCTPDEIVNAAGIATSNLLPEKSKDQYLKEYDLFMKWRTEKHVGNFSERVLLCYLEEKSKQWKPPTLWSTYSKLKATLLINNNVDIRKYSSQVGLLIKKLFIINRSVGHKPNKSRTFSRDEMYKFLHNAPDEHISLLTNKIDDLEMYSRRNCLLVHGVRENPQENIIHVVKDVIDTMNIDDWVFDESKESPKPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B6Z5</accession>
    <name>A0A5N4B6Z5_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_02347</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0805377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B6Z5"/>
    <dbReference type="InParanoid" id="A0A5N4B6Z5"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0805377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="300" mass="34490" checksum="C715C5D3032680DE" modified="2020-02-26" version="1">MSHQQVFPQEKINEFLNRSKSRKVPLFMDVEEESSSSPTPLTPPPQSSPKSTVSTVSDGGITKTCWNNIYGLDFNEISTQTSEVEDNYTFMNHTDELISPLIYKYDSNGNGCEKILSIGYSLWKDAAPIVRIGCSKCCGFIDFTPPEWYNLTQLSTFDEDDEVVNYREMDSAIYHNPKARSLHYGDGEFRCSVEVESFIKLFRLKHMVNYYLEMLTSYNFNIFYQRFIDLIAEYVDATSSNDLINTAFSILNPSLNINSFNILCILEILHRYPGEVIDKVHKSRNHQILQQQNLWTAAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B732</accession>
    <name>A0A5N4B732_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_02346</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0805376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B732"/>
    <dbReference type="InParanoid" id="A0A5N4B732"/>
    <dbReference type="OrthoDB" id="676304at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044822">
        <property type="entry name" value="Myb_DNA-bind_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47595">
        <property type="entry name" value="HEAT SHOCK 70 KDA PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47595:SF1">
        <property type="entry name" value="MYB_SANT-LIKE DNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13837">
        <property type="entry name" value="Myb_DNA-bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="33"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="162"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0805376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="234" mass="27053" checksum="FC2E4F3A66DE85AE" modified="2020-02-26" version="1">MLVNVAQEFVTYPVETVEIVKEFEENGNNEADLPMEDRRMWTDDSTRILIELYQKFNEEFNSGIKKFVWNKIGSHISQVVGMTITGVQCDTKWKGLVKQYKSIKKHNDTSGNDTKYWKFYACMDEILFNKPEINAVATCSSSRGLKVAPEFLETNLQHETTKNNTPSPSTSRCSTPVSNRNKPLKRKVSENAYERRHKEKLERQDRFLNIFEKLVDKLGTDANHCNNCVGDKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B746</accession>
    <name>A0A5N4B746_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PiggyBac transposable element-derived protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_02395</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0805425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B746"/>
    <dbReference type="InParanoid" id="A0A5N4B746"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599:SF6">
        <property type="entry name" value="DUAL SPECIFICITY PHOSPHATASE 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="2">
        <location>
            <begin position="112"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0805425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="579" mass="66270" checksum="58797A7CDF8EB8F9" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B7J8</accession>
    <name>A0A5N4B7J8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ornithine decarboxylase</fullName>
            <ecNumber evidence="7">4.1.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PPYR_02547</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-ornithine + H(+) = putrescine + CO2</text>
            <dbReference type="Rhea" id="RHEA:22964"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:326268"/>
            <dbReference type="EC" id="4.1.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amine and polyamine biosynthesis; putrescine biosynthesis via L-ornithine pathway; putrescine from L-ornithine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer. Only the dimer is catalytically active, as the active sites are constructed of residues from both monomers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the Orn/Lys/Arg decarboxylase class-II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.17" evidence="7"/>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0805577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B7J8"/>
    <dbReference type="InParanoid" id="A0A5N4B7J8"/>
    <dbReference type="OrthoDB" id="5034579at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004586">
        <property type="term" value="F:ornithine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033387">
        <property type="term" value="P:putrescine biosynthetic process from arginine, via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00622">
        <property type="entry name" value="PLPDE_III_ODC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.10:FF:000005">
        <property type="entry name" value="Ornithine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="entry name" value="Alanine racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="entry name" value="Lyase, Ornithine Decarboxylase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022643">
        <property type="entry name" value="De-COase2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022653">
        <property type="entry name" value="De-COase2_pyr-phos_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000183">
        <property type="entry name" value="Orn/DAP/Arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002433">
        <property type="entry name" value="Orn_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11482">
        <property type="entry name" value="ARGININE/DIAMINOPIMELATE/ORNITHINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11482:SF6">
        <property type="entry name" value="ORNITHINE DECARBOXYLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00278">
        <property type="entry name" value="Orn_DAP_Arg_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01179">
        <property type="entry name" value="ODADCRBXLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01182">
        <property type="entry name" value="ORNDCRBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="Alanine racemase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="PLP-binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00878">
        <property type="entry name" value="ODR_DC_2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orn/DAP/Arg decarboxylase 2 C-terminal" evidence="12">
        <location>
            <begin position="36"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="Orn/DAP/Arg decarboxylase 2 N-terminal" evidence="13">
        <location>
            <begin position="42"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAB0805577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="439" mass="49480" checksum="F35013821E223DBD" modified="2020-02-26" version="1">MNFENNFQSVDVYKNDISVTRIIAEKILQRKSTAPFYVCDLREIFEKHSLWTRSLPRVKPFFAVKANNCANVLKMLADVGVNFDCASKNEIDQILSLGVHPERIIYAHPVKPPNSIEYAKEVGVKLITFDNAEELSKMKKLYSDVRAVLRIRSDAKESILSYGSKFGCNSDNEAARLIQLARTLDVDLVGVSFHVGTECHDLEAFSNAIQKAHAVFSMAKLQGFNPNVLDIGGGFTGVNDQWFKKIAQTINNALELYFPNESMEIIAEPGSFFVNSSFTLACNVLSKKLEMNKKLTYYINDGIHGSFRRDYCFNVPVTVYPLKKYYKRKLYKSIIYGSSSAIPDVLTSDALLPVLEIGDWLLFLNMGAYCTSLCTFYDGFSGPDVCYVVNPDNCSQLSFTLQWPTINEKELPINDLNTNKKFISTFDVDKVSVGIFLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1JTS6</accession>
    <name>A0A1Y1JTS6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GMP reductase</fullName>
            <shortName evidence="8">GMPR</shortName>
            <ecNumber evidence="8">1.7.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Guanosine 5'-monophosphate oxidoreductase</fullName>
            <shortName evidence="8">Guanosine monophosphate reductase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PPYR_00134</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 8 11">Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8 11">
            <text>IMP + NH4(+) + NADP(+) = GMP + NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:17185"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.7.1.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.7.1.7" evidence="8"/>
    <dbReference type="EMBL" id="GEZM01103141">
        <property type="protein sequence ID" value="JAV51528.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1JTS6"/>
    <dbReference type="InParanoid" id="A0A1Y1JTS6"/>
    <dbReference type="OrthoDB" id="418595at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902560">
        <property type="term" value="C:GMP reductase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003920">
        <property type="term" value="F:GMP reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006163">
        <property type="term" value="P:purine nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00381">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000012">
        <property type="entry name" value="GMP reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00596">
        <property type="entry name" value="GMP_reduct_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050139">
        <property type="entry name" value="GMP_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005993">
        <property type="entry name" value="GMPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015875">
        <property type="entry name" value="IMP_DH/GMP_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001093">
        <property type="entry name" value="IMP_DH_GMPRt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01305">
        <property type="entry name" value="GMP_reduct_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003470">
        <property type="entry name" value="PRK05096.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43170">
        <property type="entry name" value="GMP REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43170:SF5">
        <property type="entry name" value="GMP REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00478">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000235">
        <property type="entry name" value="GMP_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01240">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00487">
        <property type="entry name" value="IMP_DH_GMP_RED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 8 11" id="KW-0521">NADP</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 8 10" id="KW-0630">Potassium</keyword>
    <keyword evidence="1 8" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IMP dehydrogenase/GMP reductase" evidence="12">
        <location>
            <begin position="10"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="active site" description="Thioimidate intermediate" evidence="8 9">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="8">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="26"/>
            <end position="27"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="8">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="8">
        <location>
            <begin position="129"/>
            <end position="131"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="8">
        <location>
            <begin position="180"/>
            <end position="181"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="219"/>
            <end position="221"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="242"/>
            <end position="243"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="268"/>
            <end position="270"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="8">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="8">
        <location>
            <begin position="285"/>
            <end position="286"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="286"/>
            <end position="290"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="314"/>
            <end position="317"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000235-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000235-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="JAV51528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAB0803164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="345" mass="37305" checksum="154FA222DFD8BB6A" modified="2017-08-30" version="1">MPNIVNEIKLDFKDVMLRPKRSTLMSRNDVDLYRKITFRNSKQTYHGIPIMASNMDTVGTFEIAKALSKHGLFTTLHKYYGVEEWKKFAEENPDCLSNIAVSAGMSNSDYDRLSQILNAVPGIAFICLDVANGYSQGFVEFVRKVRAAFPTHTIMAGNVVTGEMVEELILSGADIIKVGIGPGSVCTTRMKTGVGYPQLSAVIECADAAHGLQGHIISDGGCTCGGDIAKAFGAGADFVMAGGMFAGHDQCDGEIIEKNGKKYKLFYGMSSSVAMEKHSGGVADYRASEGKTVEVPYKGNVDATVLDILGGLRSACTYTGAAKLKELPRRATFIRCTQQLNPMYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1JWN2</accession>
    <name>A0A1Y1JWN2_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Complex I-ESSS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">NADH-ubiquinone oxidoreductase ESSS subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PPYR_12395</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="19 20" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">1611_PpyrPB1</strain>
            <tissue evidence="19">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">1611_PpyrPB1</strain>
            <tissue evidence="19">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Complex I is composed of 45 different subunits. Interacts with BCAP31.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFB11 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01102783">
        <property type="protein sequence ID" value="JAV51795.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01102782">
        <property type="protein sequence ID" value="JAV51797.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0795556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1JWN2"/>
    <dbReference type="FunCoup" id="A0A1Y1JWN2">
        <property type="interactions" value="405"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1JWN2"/>
    <dbReference type="OrthoDB" id="5917019at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019329">
        <property type="entry name" value="NADH_UbQ_OxRdtase_ESSS_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13327:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 11, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13327">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE ESSS SUBUNIT, MITOCHONDRIAL PRECURSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10183">
        <property type="entry name" value="ESSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="7 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00031387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00046528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="JAV51795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAB0795556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="145" mass="16449" checksum="1DB1486F43387A0C" modified="2017-08-30" version="1">MSLSQRLLTLNINHARRILCIRHVSTSKPKQETALVSDEKKSSEVLAKISSNWISYGFDSKDEKWDRTVMHLSMFGGITLGLVLVAYGFMYAPDVNLKHWAQREAFLELRRREAKGLKPIDPNLVDPSLVILPSDEELGNTEVII</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1JXJ4</accession>
    <name>A0A1Y1JXJ4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PPYR_01028</name>
        <name evidence="7" type="ORF">PPYR_13032</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GEZM01102888">
        <property type="protein sequence ID" value="JAV51745.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01102887">
        <property type="protein sequence ID" value="JAV51746.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1JXJ4"/>
    <dbReference type="InParanoid" id="A0A1Y1JXJ4"/>
    <dbReference type="OrthoDB" id="3026777at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF1">
        <property type="entry name" value="FI18259P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="126"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="162"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="289"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="326"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="382"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="415"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="447"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="JAV51746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0793412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0804058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="497" mass="56104" checksum="5A747B70EF0E3FE2" modified="2017-08-30" version="1">MEGTLMDAKLKVTPRRHVRDVLCKIWKGITVEPVLILFMLPFHMSALTIQNLSLEKSCRVNLNMSDSVCDAIHQRDRSGYNDDDEVAVQKVVAAAYVWKFVVYGVFPAILLPFLGSWSDRNKTRKILLLLPIIGELITNIAFIFCTYYFYELPMEVNTLVEVLPTAITGGSNMLFLGVFTHVSAISSSEDRTFRIGIVHTLFCICVTIGSALSGVIYKGIGFYGVFSLSLVLYALAGLYAYYKVKEEAPIEKKTRTKYELMKDIVNIKKTLSTFHFLIQPNRGIQRKQIFVIVLLAIFVLGPFAGEGALLYLYTRLKFNWNEIDCSIYFGYTSVAHLTGNFAAILIFSKWLKFDDAVLGAISSVSKICGGIVFMLAEKSFVFYIGALIEAFNGTSFVASRSIITKLVEEKDLGKVNSLFGIAESLTILLYVPMYSALYKATLNIFSASFYVLGITLTIPAILLYLWLYSKRNERFVEEDFKFPESRELFSPENRNRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1K4Q2</accession>
    <name>A0A1Y1K4Q2_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Coatomer subunit epsilon</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PPYR_04212</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">1611_PpyrPB1</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">1611_PpyrPB1</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 14">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">COPI-coated vesicle membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the COPE family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01093067">
        <property type="protein sequence ID" value="JAV56363.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1K4Q2"/>
    <dbReference type="FunCoup" id="A0A1Y1K4Q2">
        <property type="interactions" value="1570"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1K4Q2"/>
    <dbReference type="OrthoDB" id="310217at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000140">
        <property type="entry name" value="Coatomer subunit epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006822">
        <property type="entry name" value="Coatomer_esu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10805">
        <property type="entry name" value="COATOMER SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10805:SF0">
        <property type="entry name" value="COATOMER SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04733">
        <property type="entry name" value="Coatomer_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016478">
        <property type="entry name" value="Coatomer_esu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12 14" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="8 14" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="10 14" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 14" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR016478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="JAV56363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAB0802026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="304" mass="34747" checksum="BD847F5D07B37730" modified="2017-08-30" version="1">MSRQQQDIDELFDVKNHFYIGNYQQCINEAQKLKKTSTPEVAIDRDIFTYRAYMAQNKFLVVLDEIHGASPARVQPLKLLAEYLSNKQKREDVVQQMEQKLESSVQDNDILVLVAATIYMHELNYEAAYKVLHTSETLEALAITLDILIKMHRIDLAKKKLKEMQDKDDDATLTQLAQAWVNVAMGGDKLQDAYYIYQELVDKYGPSPILLNNQAVTFIGQGKYEEAEAALQEALDKDSNFPDTLINFIVLSQHTGKGPEVVNRYLSQLKDKNADHPFLKDLKQKQEEFAHICQQYGPSTSARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1K648</accession>
    <name>A0A1Y1K648_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HIT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PPYR_05991</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01097344">
        <property type="protein sequence ID" value="JAV54267.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000004">
        <property type="protein sequence ID" value="KAB0800251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1K648"/>
    <dbReference type="InParanoid" id="A0A1Y1K648"/>
    <dbReference type="OrthoDB" id="672793at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01276">
        <property type="entry name" value="PKCI_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.428.10:FF:000005">
        <property type="entry name" value="Histidine triad nucleotide-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019808">
        <property type="entry name" value="Histidine_triad_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23089">
        <property type="entry name" value="HISTIDINE TRIAD HIT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00892">
        <property type="entry name" value="HIT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="4">
        <location>
            <begin position="59"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="2 3">
        <location>
            <begin position="150"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-AMP-histidine intermediate" evidence="1">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="JAV54267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0800251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="166" mass="18823" checksum="C83EACAE568EE50F" modified="2017-08-30" version="1">MQPTNEGIFYGYLQFTRKSQSLLCHFPVHLAPFSPLNKSMGTEVDKAQHAKWSKNETTIFDKIIQKQIPAEIIYEDDHCLAFNDVNPQAPTHFLVIPKKRIPLLDASEECDKELLGTLMLTAKKLAQERLPNGYRLVINNGVDGCQSVYHLHVHILGGRQMSWPPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1K8H9</accession>
    <name>A0A1Y1K8H9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Coiled-coil domain-containing protein 130 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_14488</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CWC16 family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01091851">
        <property type="protein sequence ID" value="JAV56738.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1K8H9"/>
    <dbReference type="FunCoup" id="A0A1Y1K8H9">
        <property type="interactions" value="1225"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1K8H9"/>
    <dbReference type="OrthoDB" id="360327at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007590">
        <property type="entry name" value="Saf4/Yju2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111">
        <property type="entry name" value="SPLICING FACTOR YJU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111:SF2">
        <property type="entry name" value="SPLICING FACTOR YJU2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04502">
        <property type="entry name" value="Saf4_Yju2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="JAV56738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0792529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="313" mass="35899" checksum="FC073521B37B9B53" modified="2017-08-30" version="1">MGERKGTNKYYPPDYDPRAGGLNKWQGTHALRERARKIHMGIIIVRFEMPFNIWCEGCNNHIGMGVRYNAEKKKVGMYYTTPVFEFKMKCHLCDNHFLIKTDPGNLEYIVLSGARRQENRWDPTQNEQVVPETKETQKRLFDDSMFKLEHGTDDQNYAENAKTALVNLYNRNESTWADDYSANCMLRQAFRKNKNDFKTSIAKDNALLKKSSLNIKLVPEAEEDKQLAAVLSLKLKPKLDAEKTTELIRKNIISESSLPCTSFTPAKERKAIKVLNNNDLKKLVLINKPTQAKKIKLTPSLVGDYGNSTSESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1KD74</accession>
    <name>A0A1Y1KD74_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PPYR_08167</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">1611_PpyrPB1</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">1611_PpyrPB1</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01086411">
        <property type="protein sequence ID" value="JAV59472.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01086410">
        <property type="protein sequence ID" value="JAV59473.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1KD74"/>
    <dbReference type="FunCoup" id="A0A1Y1KD74">
        <property type="interactions" value="317"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1KD74"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11056">
        <property type="entry name" value="CYP6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000042">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050476">
        <property type="entry name" value="Insect_CytP450_Detox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292:SF100">
        <property type="entry name" value="CYTOCHROME P450 6A16, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0492">Microsome</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="439"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="JAV59472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAB0797173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="494" mass="57680" checksum="69E500771FC97B10" modified="2017-08-30" version="1">MFFEVCSFIVLVAFLGTVFIRWRYTYWKRRNVSYMSPTFPFGNYDRAYPIGVWLKICYDEFKRRDLKHAGLYIGLRPVYFPIATDFIKNVLQNDFQYFVNRGTYSNQKYDPLSAHLFNLGGQMWREMRTKLTPTFTSGKMKMMFDTLLQCTTPMQEVVTRHCLDETPVMIKEVVSRFTTDVIGSCAFGLDCNSFKDEDAPFRYYGRKIFETNRASYILTRALTTCSPAIARTLRQSLFPKETTNFFLNVVKETIKYRKHGDIQRNDMLQILIELQKKDKEGHRLSVEEMAAQCFVFFIAGFETSSSVSTFCLYELAKNIEIQRKVRDEIVKVLQKHRGQISYESLADMKYLDQVIYETMRIYPTLAAVTRECVKDYHVPGTNVIIEKNTLVLLPTLGLHKDPSYFKDPDLFDPERFSTENIHNSNPFVFMPFGQGPRNCIGMRFGMMQVKVGLTCLMRDFSFSLSPKTKPLVFNKYALITNTRDPIWLDVKKIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1KI06</accession>
    <name>A0A1Y1KI06_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NF-kappa-B-activating protein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_06438</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
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                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
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            <dbReference type="DOI" id="10.1038/srep38556"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
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        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
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        <text evidence="1">Belongs to the NKAP family.</text>
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        <property type="molecule type" value="Transcribed_RNA"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="124"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009313"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF06047"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="JAV60031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0800699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="306" mass="35805" checksum="E448A74379BDA555" modified="2017-08-30" version="1">MSKYARKVPSYRSPQRRSRSPDRYDSSYKRRKRSPSYRDKHKETESKSDRWPNSEHNSYLHHKHRSNLKRLTQEEEILEARRQEREMLGMRLCPNIWGKSPTPEESSASDSDDKKSVEESEKKEHKKRKKEKKHKRSKSKKSKKEKKRKKKRKSKSDDSSMEEWVEKEDKDKSLTVDAQTDVDGAIGPQLKTHATLTHKEMGKALLPGEGAAMAAYVAEGKRIPRRGEIGLTSDQIATFESVGYVMSGSRHRRMEAVRIRKENQIYSADEKRALAMFSKEERQKRENLILGQFREMVNAKLSDKKK</sequence>
</entry>
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    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
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            <dbReference type="DOI" id="10.1038/srep38556"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
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        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01075894">
        <property type="protein sequence ID" value="JAV63893.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KAB0793613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="InParanoid" id="A0A1Y1KR64"/>
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    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="ZCCHC9"/>
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    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
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    <dbReference type="PANTHER" id="PTHR46242:SF1">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 9"/>
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    </dbReference>
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    </dbReference>
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        </location>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        </source>
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        <source>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
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    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
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                <person name="Al-Wathiqui N."/>
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                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat RAPTOR family.</text>
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        <property type="molecule type" value="Transcribed_RNA"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:TORC1 complex"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Leucine-rich Repeat Variant"/>
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    </dbReference>
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        <property type="entry name" value="HEAT"/>
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        <property type="entry name" value="Raptor"/>
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        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="REGULATORY-ASSOCIATED PROTEIN OF MTOR"/>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="YEAST176DUF"/>
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    </dbReference>
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        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Raptor N-terminal CASPase-like" evidence="5">
        <location>
            <begin position="50"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="804"/>
            <end position="865"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="JAV63031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0793942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1287" mass="145212" checksum="E993E0DB2360B516" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1KSP6</accession>
    <name>A0A1Y1KSP6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UDP-glucuronosyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_09212</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:132367"/>
            <dbReference type="ChEBI" id="CHEBI:132368"/>
            <dbReference type="EC" id="2.4.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Membrane</location>
            <topology evidence="5">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.17" evidence="5"/>
    <dbReference type="EMBL" id="GEZM01081078">
        <property type="protein sequence ID" value="JAV61897.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1KSP6"/>
    <dbReference type="FunCoup" id="A0A1Y1KSP6">
        <property type="interactions" value="289"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1KSP6"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015020">
        <property type="term" value="F:glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000050">
        <property type="entry name" value="UDP-glucuronosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000144">
        <property type="entry name" value="UDP-glucuronosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035595">
        <property type="entry name" value="UDP_glycos_trans_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF159">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033827398" description="UDP-glucuronosyltransferase" evidence="5">
        <location>
            <begin position="19"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="467"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="JAV61897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0798219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="512" mass="58440" checksum="3211CFCEFCAE7F34" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1KWA9</accession>
    <name>A0A1Y1KWA9_PHOPY</name>
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        <recommendedName>
            <fullName evidence="12">Ion transport peptide-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PPYR_00811</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the arthropod CHH/MIH/GIH/VIH hormone family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01075794">
        <property type="protein sequence ID" value="JAV63955.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01075791">
        <property type="protein sequence ID" value="JAV63958.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1KWA9"/>
    <dbReference type="FunCoup" id="A0A1Y1KWA9">
        <property type="interactions" value="59"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:neuropeptide hormone activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:circadian rhythm"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Ion transport peptide isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Hyperglycemic1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35981">
        <property type="entry name" value="ION TRANSPORT PEPTIDE, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35981:SF2">
        <property type="entry name" value="ION TRANSPORT PEPTIDE, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01147">
        <property type="entry name" value="Crust_neurohorm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00548">
        <property type="entry name" value="HYPRGLYCEMC1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00550">
        <property type="entry name" value="HYPRGLYCEMIC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81778">
        <property type="entry name" value="Crustacean CHH/MIH/GIH neurohormone"/>
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    </dbReference>
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        <property type="entry name" value="CHH_MIH_GIH"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="6 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0372">Hormone</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
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    <feature type="chain" id="PRO_5011907309" description="Ion transport peptide-like protein" evidence="8">
        <location>
            <begin position="30"/>
            <end position="125"/>
        </location>
    </feature>
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        <location>
            <begin position="53"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="69"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="72"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR631098-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="JAV63955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0803841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="125" mass="14549" checksum="A43C21D96667FE9F" modified="2017-08-30" version="1">MHRRSSTSIYTKGVWVCMALTLVIQLAHCTPTQRSRPLLSHHLTKRAFADQQCKGVYDKSIYARLDRICEDCYNLFREPELHSLCKKNCFTSEFFKACLDSLQLQDEMEQIQIWIKQLHGAEPGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1L0E1</accession>
    <name>A0A1Y1L0E1_PHOPY</name>
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        <recommendedName>
            <fullName evidence="8">LRRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PPYR_14182</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01068149">
        <property type="protein sequence ID" value="JAV67139.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1L0E1"/>
    <dbReference type="InParanoid" id="A0A1Y1L0E1"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050541">
        <property type="entry name" value="LRR_TM_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369">
        <property type="entry name" value="ANTIGEN BSP, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369:SF210">
        <property type="entry name" value="CHAOPTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036029832" description="LRRCT domain-containing protein" evidence="4">
        <location>
            <begin position="31"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="JAV67139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0792223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="393" mass="44402" checksum="31328EF385229A1C" modified="2017-08-30" version="1">MSIVSVHWQSSTVMFLKVLCVLNAFALVQCCNSFGSINVQVQDKAQRVFNRTIKGCISKKSFTDDAFVSHTWIREQPVLRLKTGAVENTPDLEFVKFSHCKIASITPNAFRDVPNLQGVHIEHGSLTLIKRNVFKGSQIPRLLELSLAHNEISNIEVKAFAYSTFRKLSLSNNKLAKWYPGWFTDASATPIDADAFNQLSSKPLSENYTISPLEEIDFSNNLLTELPLDTLIALPNLKVFNLDANRILSIEPGTFHRTKLDTLRLARNRLAYVDPKWFPKPFRLSHLTLNANKLNFIPEEFFQRVHPSLLALDGNPMTCACQTKTMRALYSKNYEIETTENCSWPNVPICIGLEDGVCAEEVDEGVTRQYHEAIISALRNVSASIRDQCYSLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1L3A8</accession>
    <name>A0A1Y1L3A8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Serpin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PPYR_05779</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the serpin family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01068631">
        <property type="protein sequence ID" value="JAV66850.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000003">
        <property type="protein sequence ID" value="KAB0801425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1L3A8"/>
    <dbReference type="FunCoup" id="A0A1Y1L3A8">
        <property type="interactions" value="31"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1L3A8"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19578">
        <property type="entry name" value="serpinK_insect_SRPN2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.39.10:FF:000030">
        <property type="entry name" value="Serpin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.39.10">
        <property type="entry name" value="Alpha-1-antitrypsin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.497.10">
        <property type="entry name" value="Antithrombin, subunit I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023796">
        <property type="entry name" value="Serpin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000215">
        <property type="entry name" value="Serpin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036186">
        <property type="entry name" value="Serpin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042178">
        <property type="entry name" value="Serpin_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042185">
        <property type="entry name" value="Serpin_sf_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461:SF357">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR 27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR, SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
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            <begin position="19"/>
            <end position="462"/>
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            <begin position="55"/>
            <end position="418"/>
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            <begin position="415"/>
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            <begin position="102"/>
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            <begin position="430"/>
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        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
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    <sequence length="462" mass="51588" checksum="24D89287BAE9365F" modified="2017-08-30" version="1">MGLYGIVVALCVINGVHLAENPTEAPTNEASSYNDADDSNDEYFPVMDWSDTFDWQLLKAIANEHSNNILISPLSIKLALVVLYEGSEGSTKKQFQSVMQYSDQKSEVNAKYRNLLANLEKNKKDYIINIGTRIFLDSTITPLQQYAANVKSSYNTEIKSTNFTDHVAAENLINSWVDGLTHGNIKKLINADEIQDDTLLLVANAVFFKGKWRRKFPVEKSYQGGFYVSPKEVITVDYMANTDTYYYGESKELDAKLLRLPYKGANFGFFIVLPNTKGGLSELLKSVNLQTLKRQLYLMDERKVDVVIPKFKFDFSASYSKILQDFGLTAMFSNTASFPGIARGIGSGGKWLFVNDLKQKSGIEFNEEGSSAFAATEIQLGNKFGESDISFNATHPFLFFIEHQETGSILFAGKMMNPLQNDGPVPPEPESTNSKPPSGENNTAANWRPNNVQIVKPNKQIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LBM0</accession>
    <name>A0A1Y1LBM0_PHOPY</name>
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        <recommendedName>
            <fullName evidence="3">chitinase</fullName>
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        </recommendedName>
    </protein>
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        <name evidence="18" type="ORF">PPYR_14388</name>
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        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">1611_PpyrPB1</strain>
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    <reference evidence="18" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">1611_PpyrPB1</strain>
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        </source>
    </reference>
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        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
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        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="73875at2759"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Glyco_hydro18_cat"/>
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        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
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    </dbReference>
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        <property type="entry name" value="CHITINASE 5"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Glyco_hydro_18"/>
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    </dbReference>
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        <property type="entry name" value="ChtBD2"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="GH18_2"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="7" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="4" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036312539" description="chitinase" evidence="14">
        <location>
            <begin position="18"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="16">
        <location>
            <begin position="20"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="15">
        <location>
            <begin position="471"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="398"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="448"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="JAV68457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAB0792429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="529" mass="59776" checksum="B93302DF7C53379A" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LGI0</accession>
    <name>A0A1Y1LGI0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PPYR_14501</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
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        <source>
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    </evidence>
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        <source>
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    <sequence length="303" mass="33766" checksum="79B6E9155A337461" modified="2017-08-30" version="1">MFKVSGILLYLISASLGNHVLITQIKNDIEIPIRSSLVTASMGDKVSLHCKLIGNDTTKNLGVQWIANPSFNLKFAEHDFSTIVLYPLMPNNAGTYTCVSKNRKSSAVVDLFVIPGRTDYQKEIREMEARLAQVHNTNFDRFANMMETKTLPPMEFNFLKERKLITSSTYTTFKQLVYIVPVTILLILSLVRFCYYLGNRSQIPWQQLNTPITSCEHQICAYRRRTNPAAPCILSRTNRGLSVLIIQRAASSTSDSATNLVTEEDAPPAYNDVNADSPPTYTEAVETMDGALPCATPNSNASI</sequence>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
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        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
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            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
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            <dbReference type="PubMed" id="30324905"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
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                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="5">1611_PpyrPB1</strain>
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        </source>
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    </evidence>
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    <sequence length="415" mass="45895" checksum="66CD9E9F74F20384" modified="2017-08-30" version="1">MVSFRLLLVLFCFRVIDAQLEGGLLGLLKPDGVQISLPGLLGLTDKRKSTTATTTTTSTTTTTTTPAPLTQASVTSKKPTGPAAACGYTPTFVNGKRSCRGKLIFQDGFSKLAGKWFTENRFAGEPDYEFTIYQGNAENLYLNKNKLHIRPTLTDDKYGNGFVTGDRELNLGDTCTGRPATEDCVQRPRAWMIVPPTISSMISTKKHFSFLYGIVEIRARLPKGDWIYPQLYLKPKSEFYGAGYESGLIKIAHVAGNANMSKTLAGGVILSQSDFGRNYGIKNVSSPTHWNHDFHDFKIVWTADSITFTVDDEVYGVVEPPEDGFGSLSDLEHSPEVLEKWKQGSKIAPFDKEMYLVLGIGVGGQLFPDSEGSAKPWENFDPKGPLNFYKARDVWKKTWGDTSDLVIDQVKVWAL</sequence>
</entry>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
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                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
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                <person name="Schmitz R.J."/>
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                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <text evidence="1">Homodimer.</text>
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        <source>
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    </evidence>
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        <source>
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        </source>
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    <sequence length="216" mass="24515" checksum="F9FCA5EF7CF00030" modified="2017-08-30" version="1">MVLTLYKMDMSSCCRAVLLTIKALDLPVEYVEVNLLKREASAPHIAKLNPRCKIPILEDNGAVIWDSHAINAYLVQTYGKDCKLYPSDAAGQANVQGWLYFDTEIFAKLNDLMVQVSTTRTISEQTYEEVRNIYHVLNNYLKEKKWITGDNVTIADFSLLSTIESFNCCLEVDPNKYANVARWLGEAQKLPFYEVTTKKGIEDLAGFLKFLLSAKK</sequence>
</entry>
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    </organism>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
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                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">1611_PpyrPB1</strain>
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    </reference>
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        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Photinus pyralis genome working group"/>
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                <person name="Sander Lower S.E."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">1611_PpyrPB1</strain>
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        </source>
    </reference>
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        <reaction evidence="7 11">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
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            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
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    </comment>
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        <text evidence="11">Belongs to the protein kinase superfamily. Tyr protein kinase family.</text>
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    </dbReference>
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    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0829">Tyrosine-protein kinase</keyword>
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        <location>
            <begin position="9"/>
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        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="13">
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        </location>
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    <feature type="binding site" evidence="10">
        <location>
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        <ligand>
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    </evidence>
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    </evidence>
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        <source>
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        <source>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
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    </evidence>
    <sequence length="740" mass="84121" checksum="8EBD50590AC37874" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
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                <person name="Fallon T.R."/>
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                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
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            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
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            <dbReference type="PubMed" id="30324905"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
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    <reference evidence="3" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01034973">
        <property type="protein sequence ID" value="JAV83451.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="JAV83454.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="JAV83456.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="JAV83457.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
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        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01034968">
        <property type="protein sequence ID" value="JAV83462.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01034967">
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        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="JAV83470.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01034965">
        <property type="protein sequence ID" value="JAV83471.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01034964">
        <property type="protein sequence ID" value="JAV83473.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01034963">
        <property type="protein sequence ID" value="JAV83476.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="JAV83479.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01034961">
        <property type="protein sequence ID" value="JAV83482.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="JAV83483.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
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        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
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    </dbReference>
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        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="JAV83496.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="JAV83498.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="JAV83501.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01034953">
        <property type="protein sequence ID" value="JAV83503.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="JAV83505.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1MD22"/>
    <dbReference type="InParanoid" id="A0A1Y1MD22"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="JAV83471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0799576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="113" mass="13093" checksum="7A993180B22BAF1B" modified="2017-08-30" version="1">MSKRRKLPFKLLSARSQRRRMYDTDDEDDSTNLSNADKDIETVSLSDDQKAIHSESVTRSMHNQSAFDSNLDSNFETSQTIDHSHLSMQYGAYGETVHACQTYYRIDYCTVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1MK99</accession>
    <name>A0A1Y1MK99_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Fatty acid desaturase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PPYR_04519</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">1611_PpyrPB1</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">1611_PpyrPB1</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="12">The histidine box domains are involved in binding the catalytic metal ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01029031">
        <property type="protein sequence ID" value="JAV86162.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1MK99"/>
    <dbReference type="FunCoup" id="A0A1Y1MK99">
        <property type="interactions" value="72"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1MK99"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004768">
        <property type="term" value="F:stearoyl-CoA 9-desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006636">
        <property type="term" value="P:unsaturated fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03505">
        <property type="entry name" value="Delta9-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015876">
        <property type="entry name" value="Acyl-CoA_DS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351">
        <property type="entry name" value="ACYL-COA DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351:SF21">
        <property type="entry name" value="GH07782P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00075">
        <property type="entry name" value="FACDDSATRASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="3 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid desaturase" evidence="14">
        <location>
            <begin position="75"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="JAV86162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAB0802333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="345" mass="40420" checksum="54F7FA111B0B724A" modified="2017-08-30" version="1">MPPQTTTPICADLARNIESEHHATTVQKEKYYKSYFGTFGAELKWVNIIAIFALHALGFWVVFAFPYWYHKRLFVYGVFIGQLTGLGITAGAHRLWTHRSYKAKLPLRIFLMLCFSLAAQNDLFEWVRDHRVHHKYSETDADPHNVNRGFFFAHCGWLMMKKHPEVIRRGKEIDMSDILEDPVVQFHLRYFTPLKIMIAFVLPSIIPPLLWGEDWFWSIMAISVARYALSLNFTWSVNSAAHIWGSKPYDRHIAPGENIWVSMVANGEGWHNYHHTFPWDYKTSEFFNVNSTARWIRLFEKMGWAYDLKSASKELIEKVAKNRGDRSRFEDIHFEVNENGDVVNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1MKA9</accession>
    <name>A0A1Y1MKA9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PPYR_03240</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01028984">
        <property type="protein sequence ID" value="JAV86172.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1MKA9"/>
    <dbReference type="InParanoid" id="A0A1Y1MKA9"/>
    <dbReference type="OrthoDB" id="9936054at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <sequence length="403" mass="46203" checksum="31A4D8D3E9A86378" modified="2017-08-30" version="1">MTEEDCVAVVKTEQREEEDQNSNLSSYEFFNYTYSYPLFGEFAAKVEVEDDTGGVETEPITILEEVPDAEPVNVDLPSRKKGSYCVKPKPTGRPYVCTICRKAFAYKNVLRIHILGVHTVDKPVKCKVCGKGFPQQSYLTIHMRSHTGERPFKCQLCDKAFTIKTILKSHMRTHTGEKPYQCHLCPKAYRQSSDLSKHVRTHSGVKPYNCHLCNGSFNHVSHLNRHIEAKTCVMPFKCNLCEFSSKNAIKLERHIRLHNGKRPYKCSLCEKDFNSSAHLSRHYGTHSGLKPYKCETCGKGFNQNHNLKSHVRTHNGEKPHECQVCGKRFGHKPDLTVHMRTHTGEKPHKCLVCDKSFNSSHSLTRHVRTHTGEKPYRCIACFKSFVDNAHLNRHMKIHLKLKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
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                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
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            <dbReference type="DOI" id="10.1038/srep38556"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
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                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
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            <dbReference type="PubMed" id="30324905"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </reference>
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        <text evidence="1">Belongs to the SS18 family.</text>
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    </evidence>
    <sequence length="391" mass="42102" checksum="BEC4BF5E2B47DF5A" modified="2017-08-30" version="1">MSVSYAQQRGGRAPPSTSQIQKVLDENGSLIQTIQDYQNKGKPQDCIQYQQLLHRNLVYLASIADASQNVNALLPPPPGSGPPIGQPPPNPDPQHINNYSHHPHQPQQQNYRQPLGPQRPANPQQPYPQRNYQQGQYPGQYPPQGGVYPQQGQYPPSQPPGYPANAQSSYGQPPPTTSHSSYPQPNYPTPPPTTAPPQSNPYTPPPAPPHSQSASYVTPPTNAPYPNANPPQNYPPQQSYPPQQSYPPPAANQPQPTPTPPFGNQTTPAVPSNYPPNPANAQSPPFTGPPSNAVNPAAAPSSAPPATSQSYQPPYPPNSQPSNPNPGYTPPNQAYPPPGANYVYPPQPGYPPQPQYAGQPQGYQYARPPPSQAPPPQGQYSYSYPPQPAPQ</sequence>
</entry>
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    <accession>A0A1Y1N1T2</accession>
    <name>A0A1Y1N1T2_PHOPY</name>
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        <recommendedName>
            <fullName evidence="3">Chromatin modification-related protein MEAF6</fullName>
        </recommendedName>
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        <name evidence="13" type="ORF">PPYR_09340</name>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
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            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
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            <taxon>Lampyridae</taxon>
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            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
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                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
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            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the EAF6 family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01016154">
        <property type="protein sequence ID" value="JAV91358.1"/>
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        <source>
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        <source>
            <dbReference type="EMBL" id="KAB0798347.1"/>
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    </evidence>
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        <source>
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    </evidence>
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</entry>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
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        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
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    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </reference>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="358" mass="40787" checksum="8EEFCD7749114BE8" modified="2017-08-30" version="1">MCNTGLCGILKNCGLIFIYIYGSCHIAFEMIQTIIPIGIILIFIFTFGLYAVKVPPPDEDTVKKLIGLPLTEESENPTEYYMKTVAHRGAGLDAPENSLVAFDLCSKKGCNIIEFDVTLTADNVPVVFHDKTLDRVADSEKVLSKTLWEDLQKIDISVRHPYRERFINTRIPTLDETVQQLLKAEQRMFIDIKTQNGKIIDIILDLYEKYPSLHSMAVVTSFYPNIIYYIRRSNPKIVCSLAWRPYSFANVSYNAMTGPGERRSTNILKHLFLCLCDNLHEWLLPRLTYNILGLSMVLLHKDVISPKVVADWQAKGVRVMAWTVNHPIDKQYFAKTLKITYLTDTLTGESTVHSNSLE</sequence>
</entry>
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    <name>A0A1Y1N493_PHOPY</name>
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            <fullName evidence="9">CTF/NF-I domain-containing protein</fullName>
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    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
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            <dbReference type="PubMed" id="28004739"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
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            <authorList>
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                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
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    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="11">1611_PpyrPB1</strain>
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        </source>
    </reference>
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        <subcellularLocation>
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    </comment>
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</entry>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
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            <dbReference type="DOI" id="10.1038/srep38556"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
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                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
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                <person name="Bessho-Uehara M."/>
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                <person name="Debat H.J."/>
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                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
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                <person name="Shigenobu S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="JAV92167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0792719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="132" mass="14808" checksum="D359CB1C021A0D2D" modified="2017-08-30" version="1">MAIHIQGGKDIAKSSIEENIQSMPFKISADCDAKVSTYFKPLVKVNEDSIYSSSFRGHPLSGKKLAIPDGYMGVVLHETVPPGTDKVDRNFYIVNKFDSFMHWNWDKTPTLNDPIMQALHVWIDVAEALHSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2023-09-13" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1NBP5</accession>
    <name>A0A1Y1NBP5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein sleepless</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_13106</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01011111">
        <property type="protein sequence ID" value="JAV93646.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1NBP5"/>
    <dbReference type="InParanoid" id="A0A1Y1NBP5"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036312597" description="Protein sleepless" evidence="1">
        <location>
            <begin position="19"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="JAV93646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0793486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="128" mass="14800" checksum="3248337E9D82142D" modified="2017-08-30" version="1">MWPLLVVVISLSCRVGQALDCYRCDSITRGFDTEIQLVDCKTLHNPYRNGTLRVLLECVQEQKVFLATGDNNRLCQQQNAIATNFQEKGKMKKCEILHRDKCNSTRNTKLTLVLNLIAFFIFYECTNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N3ZYR8</accession>
    <name>A0A5N3ZYR8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PPYR_15467</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Antp homeobox family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01001688">
        <property type="protein sequence ID" value="KAB0790201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N3ZYR8"/>
    <dbReference type="InParanoid" id="A0A5N3ZYR8"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009952">
        <property type="term" value="P:anterior/posterior pattern specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050296">
        <property type="entry name" value="Antp_homeobox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45659:SF4">
        <property type="entry name" value="HOMEOBOX PROTEIN ABDOMINAL-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45659">
        <property type="entry name" value="HOMEOBOX PROTEIN HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0371">Homeobox</keyword>
    <keyword evidence="6 7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="10">
        <location>
            <begin position="4"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="7">
        <location>
            <begin position="6"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="63"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="79"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0790201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="134" mass="15757" checksum="E83D084C8E793076" modified="2020-02-26" version="1" fragment="single">DSSQGGKRTRQTYTRYQTLELEKEFHFNRYLTRRRRIEISHALCLTERQIKIWFQNRRMKAKKDNKFSPSEDFPEQDDINMNNTITSTNNGTSPYTNINSPELCTVSQERNLFDESVAIPMTQLRNLPGPPCLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N3ZYS9</accession>
    <name>A0A5N3ZYS9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CWH43-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PPYR_15455</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DRAM/TMEM150 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01001675">
        <property type="protein sequence ID" value="KAB0790209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N3ZYS9"/>
    <dbReference type="InParanoid" id="A0A5N3ZYS9"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019402">
        <property type="entry name" value="CWH43_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050911">
        <property type="entry name" value="DRAM/TMEM150_Autophagy_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21324:SF2">
        <property type="entry name" value="EG:22E5.9 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21324">
        <property type="entry name" value="FASTING-INDUCIBLE INTEGRAL MEMBRANE PROTEIN TM6P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10277">
        <property type="entry name" value="Frag1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="CWH43-like N-terminal" evidence="7">
        <location>
            <begin position="2"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0790209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="250" mass="28556" checksum="0E5DB229F5EFAB6B" modified="2020-02-26" version="1">MHYLPIVTCGWFILTVAVTYLISVLNGHVYPLVPYISDTGTKPYESCVFGQMLNIGALLLGVNNYIRYRQVDLAIQSKNVNLKEKWNTVALWLGMIISLGISIVANFQQKPLFAIHMVGALMSFGFSTIYFIIQARISFAFRHLHKKYPKYTVGSCIIYFRIVLCACYTILFFMVFSFSPMAFKQFKGDDLLYWTPEDGGFGYHITATLSEWGLLCIMIVFVFTGSAEFKTIGFHEISFRSKLFDMTMDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N3ZYY5</accession>
    <name>A0A5N3ZYY5_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_15386</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01001567">
        <property type="protein sequence ID" value="KAB0790277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N3ZYY5"/>
    <dbReference type="InParanoid" id="A0A5N3ZYY5"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33480">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0790277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="67" mass="7571" checksum="7DA5DD920057CB1D" modified="2020-02-26" version="1" fragment="single">TVPWGKGDVAIRTLTTNMKLKNPTAMSSNKLGKQIATVMQLLNLSKDESKQFAQFMGHTEKTHQEFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A167</accession>
    <name>A0A5N4A167_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_02846</name>
        <name evidence="2" type="ORF">PPYR_02867</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A167"/>
    <dbReference type="InParanoid" id="A0A5N4A167"/>
    <dbReference type="OrthoDB" id="6629909at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33053:SF9">
        <property type="entry name" value="AGAP000105-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33053">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0791046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0791067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="675" mass="77441" checksum="EBEB699256119E71" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A1P5</accession>
    <name>A0A5N4A1P5_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="51">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="51" type="ORF">PPYR_03042</name>
    </gene>
    <organism evidence="51 52">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="51 52" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="51">1611_PpyrPB1</strain>
            <tissue evidence="51">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>(2E)-butenoyl-[ACP] + NADPH + H(+) = butanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41812"/>
            <dbReference type="Rhea" id="RHEA-COMP:9627"/>
            <dbReference type="Rhea" id="RHEA-COMP:9628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78453"/>
            <dbReference type="ChEBI" id="CHEBI:78454"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:41813"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="46">
            <text>(2E)-decenoyl-[ACP] + NADPH + H(+) = decanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41864"/>
            <dbReference type="Rhea" id="RHEA-COMP:9639"/>
            <dbReference type="Rhea" id="RHEA-COMP:9640"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78467"/>
            <dbReference type="ChEBI" id="CHEBI:78468"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="46">
            <dbReference type="Rhea" id="RHEA:41865"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="30">
            <text>(2E)-dodecenoyl-[ACP] + NADPH + H(+) = dodecanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41880"/>
            <dbReference type="Rhea" id="RHEA-COMP:9643"/>
            <dbReference type="Rhea" id="RHEA-COMP:9644"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65264"/>
            <dbReference type="ChEBI" id="CHEBI:78472"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="30">
            <dbReference type="Rhea" id="RHEA:41881"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>(2E)-hexadecenoyl-[ACP] + NADPH + H(+) = hexadecanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41912"/>
            <dbReference type="Rhea" id="RHEA-COMP:9651"/>
            <dbReference type="Rhea" id="RHEA-COMP:9652"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78481"/>
            <dbReference type="ChEBI" id="CHEBI:78483"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:41913"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>(2E)-hexenoyl-[ACP] + NADPH + H(+) = hexanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41832"/>
            <dbReference type="Rhea" id="RHEA-COMP:9631"/>
            <dbReference type="Rhea" id="RHEA-COMP:9632"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78458"/>
            <dbReference type="ChEBI" id="CHEBI:78459"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:41833"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="39">
            <text>(2E)-octadecenoyl-[ACP] + NADPH + H(+) = octadecanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41928"/>
            <dbReference type="Rhea" id="RHEA-COMP:9655"/>
            <dbReference type="Rhea" id="RHEA-COMP:9656"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78489"/>
            <dbReference type="ChEBI" id="CHEBI:78495"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="39">
            <dbReference type="Rhea" id="RHEA:41929"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="32">
            <text>(2E)-octenoyl-[ACP] + NADPH + H(+) = octanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41848"/>
            <dbReference type="Rhea" id="RHEA-COMP:9635"/>
            <dbReference type="Rhea" id="RHEA-COMP:9636"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78462"/>
            <dbReference type="ChEBI" id="CHEBI:78463"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="32">
            <dbReference type="Rhea" id="RHEA:41849"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="41">
            <text>(2E)-tetradecenoyl-[ACP] + NADPH + H(+) = tetradecanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41896"/>
            <dbReference type="Rhea" id="RHEA-COMP:9647"/>
            <dbReference type="Rhea" id="RHEA-COMP:9648"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78475"/>
            <dbReference type="ChEBI" id="CHEBI:78477"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="41">
            <dbReference type="Rhea" id="RHEA:41897"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>(3R)-hydroxybutanoyl-[ACP] = (2E)-butenoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:41808"/>
            <dbReference type="Rhea" id="RHEA-COMP:9626"/>
            <dbReference type="Rhea" id="RHEA-COMP:9627"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78451"/>
            <dbReference type="ChEBI" id="CHEBI:78453"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:41809"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(3R)-hydroxydecanoyl-[ACP] = (2E)-decenoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:41860"/>
            <dbReference type="Rhea" id="RHEA-COMP:9638"/>
            <dbReference type="Rhea" id="RHEA-COMP:9639"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78466"/>
            <dbReference type="ChEBI" id="CHEBI:78467"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:41861"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(3R)-hydroxydodecanoyl-[ACP] = (2E)-dodecenoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:41876"/>
            <dbReference type="Rhea" id="RHEA-COMP:9642"/>
            <dbReference type="Rhea" id="RHEA-COMP:9643"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78470"/>
            <dbReference type="ChEBI" id="CHEBI:78472"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:41877"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>(3R)-hydroxyhexadecanoyl-[ACP] = (2E)-hexadecenoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:41908"/>
            <dbReference type="Rhea" id="RHEA-COMP:9650"/>
            <dbReference type="Rhea" id="RHEA-COMP:9651"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78480"/>
            <dbReference type="ChEBI" id="CHEBI:78481"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:41909"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(3R)-hydroxyhexanoyl-[ACP] = (2E)-hexenoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:41828"/>
            <dbReference type="Rhea" id="RHEA-COMP:9630"/>
            <dbReference type="Rhea" id="RHEA-COMP:9631"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78457"/>
            <dbReference type="ChEBI" id="CHEBI:78458"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:41829"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(3R)-hydroxyoctadecanoyl-[ACP] = (2E)-octadecenoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:41924"/>
            <dbReference type="Rhea" id="RHEA-COMP:9654"/>
            <dbReference type="Rhea" id="RHEA-COMP:9655"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78488"/>
            <dbReference type="ChEBI" id="CHEBI:78489"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:41925"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(3R)-hydroxyoctanoyl-[ACP] = (2E)-octenoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:41844"/>
            <dbReference type="Rhea" id="RHEA-COMP:9634"/>
            <dbReference type="Rhea" id="RHEA-COMP:9635"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78461"/>
            <dbReference type="ChEBI" id="CHEBI:78462"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:41845"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(3R)-hydroxytetradecanoyl-[ACP] = (2E)-tetradecenoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:41892"/>
            <dbReference type="Rhea" id="RHEA-COMP:9646"/>
            <dbReference type="Rhea" id="RHEA-COMP:9647"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78474"/>
            <dbReference type="ChEBI" id="CHEBI:78475"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:41893"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>3-oxobutanoyl-[ACP] + NADPH + H(+) = (3R)-hydroxybutanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41804"/>
            <dbReference type="Rhea" id="RHEA-COMP:9625"/>
            <dbReference type="Rhea" id="RHEA-COMP:9626"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78450"/>
            <dbReference type="ChEBI" id="CHEBI:78451"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="27">
            <dbReference type="Rhea" id="RHEA:41805"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>3-oxodecanoyl-[ACP] + NADPH + H(+) = (3R)-hydroxydecanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41856"/>
            <dbReference type="Rhea" id="RHEA-COMP:9637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9638"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78464"/>
            <dbReference type="ChEBI" id="CHEBI:78466"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:41857"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="42">
            <text>3-oxododecanoyl-[ACP] + NADPH + H(+) = (3R)-hydroxydodecanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41872"/>
            <dbReference type="Rhea" id="RHEA-COMP:9641"/>
            <dbReference type="Rhea" id="RHEA-COMP:9642"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78469"/>
            <dbReference type="ChEBI" id="CHEBI:78470"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="42">
            <dbReference type="Rhea" id="RHEA:41873"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="43">
            <text>3-oxohexadecanoyl-[ACP] + NADPH + H(+) = (3R)-hydroxyhexadecanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41904"/>
            <dbReference type="Rhea" id="RHEA-COMP:9649"/>
            <dbReference type="Rhea" id="RHEA-COMP:9650"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78478"/>
            <dbReference type="ChEBI" id="CHEBI:78480"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="43">
            <dbReference type="Rhea" id="RHEA:41905"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="34">
            <text>3-oxohexanoyl-[ACP] + NADPH + H(+) = (3R)-hydroxyhexanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41824"/>
            <dbReference type="Rhea" id="RHEA-COMP:9629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9630"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78456"/>
            <dbReference type="ChEBI" id="CHEBI:78457"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="34">
            <dbReference type="Rhea" id="RHEA:41825"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>3-oxooctadecanoyl-[ACP] + NADPH + H(+) = (3R)-hydroxyoctadecanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41920"/>
            <dbReference type="Rhea" id="RHEA-COMP:9653"/>
            <dbReference type="Rhea" id="RHEA-COMP:9654"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78487"/>
            <dbReference type="ChEBI" id="CHEBI:78488"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:41921"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="44">
            <text>3-oxooctanoyl-[ACP] + NADPH + H(+) = (3R)-hydroxyoctanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41840"/>
            <dbReference type="Rhea" id="RHEA-COMP:9633"/>
            <dbReference type="Rhea" id="RHEA-COMP:9634"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78460"/>
            <dbReference type="ChEBI" id="CHEBI:78461"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="44">
            <dbReference type="Rhea" id="RHEA:41841"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="38">
            <text>3-oxotetradecanoyl-[ACP] + NADPH + H(+) = (3R)-hydroxytetradecanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41888"/>
            <dbReference type="Rhea" id="RHEA-COMP:9645"/>
            <dbReference type="Rhea" id="RHEA-COMP:9646"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78473"/>
            <dbReference type="ChEBI" id="CHEBI:78474"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="38">
            <dbReference type="Rhea" id="RHEA:41889"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>a (3R)-hydroxyacyl-[ACP] + NADP(+) = a 3-oxoacyl-[ACP] + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17397"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="1.1.1.100"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="20">
            <dbReference type="Rhea" id="RHEA:17399"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a (3R)-hydroxyacyl-[ACP] = a (2E)-enoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:13097"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="4.2.1.59"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:13098"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="35">
            <text>a 2,3-saturated acyl-[ACP] + NADP(+) = a (2E)-enoyl-[ACP] + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22564"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9926"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78785"/>
            <dbReference type="EC" id="1.3.1.39"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="35">
            <dbReference type="Rhea" id="RHEA:22566"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="33">
            <text>a fatty acyl-[ACP] + malonyl-[ACP] + H(+) = a 3-oxoacyl-[ACP] + holo-[ACP] + CO2</text>
            <dbReference type="Rhea" id="RHEA:22836"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:14125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:138651"/>
            <dbReference type="EC" id="2.3.1.41"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="33">
            <dbReference type="Rhea" id="RHEA:22837"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>acetyl-[ACP] + malonyl-[ACP] + H(+) = 3-oxobutanoyl-[ACP] + holo-[ACP] + CO2</text>
            <dbReference type="Rhea" id="RHEA:41800"/>
            <dbReference type="Rhea" id="RHEA-COMP:9621"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9625"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78446"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78450"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="28">
            <dbReference type="Rhea" id="RHEA:41801"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="45">
            <text>butanoyl-[ACP] + malonyl-[ACP] + H(+) = 3-oxohexanoyl-[ACP] + holo-[ACP] + CO2</text>
            <dbReference type="Rhea" id="RHEA:41820"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9628"/>
            <dbReference type="Rhea" id="RHEA-COMP:9629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78454"/>
            <dbReference type="ChEBI" id="CHEBI:78456"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="45">
            <dbReference type="Rhea" id="RHEA:41821"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="40">
            <text>decanoyl-[ACP] + malonyl-[ACP] + H(+) = 3-oxododecanoyl-[ACP] + holo-[ACP] + CO2</text>
            <dbReference type="Rhea" id="RHEA:41868"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9640"/>
            <dbReference type="Rhea" id="RHEA-COMP:9641"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78468"/>
            <dbReference type="ChEBI" id="CHEBI:78469"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="40">
            <dbReference type="Rhea" id="RHEA:41869"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>dodecanoyl-[ACP] + malonyl-[ACP] + H(+) = 3-oxotetradecanoyl-[ACP] + holo-[ACP] + CO2</text>
            <dbReference type="Rhea" id="RHEA:41884"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9644"/>
            <dbReference type="Rhea" id="RHEA-COMP:9645"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:65264"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78473"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:41885"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="37">
            <text>hexadecanoyl-[ACP] + H2O = hexadecanoate + holo-[ACP] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41932"/>
            <dbReference type="Rhea" id="RHEA-COMP:9652"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78483"/>
            <dbReference type="EC" id="3.1.2.14"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="37">
            <dbReference type="Rhea" id="RHEA:41933"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>hexadecanoyl-[ACP] + malonyl-[ACP] + H(+) = 3-oxooctadecanoyl-[ACP] + holo-[ACP] + CO2</text>
            <dbReference type="Rhea" id="RHEA:41916"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9652"/>
            <dbReference type="Rhea" id="RHEA-COMP:9653"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78483"/>
            <dbReference type="ChEBI" id="CHEBI:78487"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="29">
            <dbReference type="Rhea" id="RHEA:41917"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>hexanoyl-[ACP] + malonyl-[ACP] + H(+) = 3-oxooctanoyl-[ACP] + holo-[ACP] + CO2</text>
            <dbReference type="Rhea" id="RHEA:41836"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9632"/>
            <dbReference type="Rhea" id="RHEA-COMP:9633"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78459"/>
            <dbReference type="ChEBI" id="CHEBI:78460"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:41837"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="36">
            <text>holo-[ACP] + acetyl-CoA = acetyl-[ACP] + CoA</text>
            <dbReference type="Rhea" id="RHEA:41788"/>
            <dbReference type="Rhea" id="RHEA-COMP:9621"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78446"/>
            <dbReference type="EC" id="2.3.1.38"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="36">
            <dbReference type="Rhea" id="RHEA:41789"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="47">
            <text>octanoyl-[ACP] + malonyl-[ACP] + H(+) = 3-oxodecanoyl-[ACP] + holo-[ACP] + CO2</text>
            <dbReference type="Rhea" id="RHEA:41852"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9636"/>
            <dbReference type="Rhea" id="RHEA-COMP:9637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78463"/>
            <dbReference type="ChEBI" id="CHEBI:78464"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="47">
            <dbReference type="Rhea" id="RHEA:41853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="31">
            <text>tetradecanoyl-[ACP] + H2O = tetradecanoate + holo-[ACP] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:30123"/>
            <dbReference type="Rhea" id="RHEA-COMP:9648"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30807"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78477"/>
            <dbReference type="EC" id="3.1.2.14"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="31">
            <dbReference type="Rhea" id="RHEA:30124"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>tetradecanoyl-[ACP] + malonyl-[ACP] + H(+) = 3-oxohexadecanoyl-[ACP] + holo-[ACP] + CO2</text>
            <dbReference type="Rhea" id="RHEA:41900"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9648"/>
            <dbReference type="Rhea" id="RHEA-COMP:9649"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78477"/>
            <dbReference type="ChEBI" id="CHEBI:78478"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:41901"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="caution">
        <text evidence="51">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A1P5"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019171">
        <property type="term" value="F:(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004313">
        <property type="term" value="F:[acyl-carrier-protein] S-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141148">
        <property type="term" value="F:enoyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016297">
        <property type="term" value="F:fatty acyl-[ACP] hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08954">
        <property type="entry name" value="KR_1_FAS_SDR_x"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049391">
        <property type="entry name" value="FAS_pseudo-KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF23">
        <property type="entry name" value="FATTY ACID SYNTHASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21149">
        <property type="entry name" value="FAS_pseudo-KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="2" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="52" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0702">S-nitrosylation</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS/mFAS DH" evidence="50">
        <location>
            <begin position="307"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="49">
        <location>
            <begin position="1422"/>
            <end position="1499"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="48">
        <location>
            <begin position="307"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="48">
        <location>
            <begin position="443"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="48">
        <location>
            <position position="341"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="48">
        <location>
            <position position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00047394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00047440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00047451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00047500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00047578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00047810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00047897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00047953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00047961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00048051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00048281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00048289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="ARBA" id="ARBA00048420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="ARBA" id="ARBA00048506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="34">
        <source>
            <dbReference type="ARBA" id="ARBA00048571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="35">
        <source>
            <dbReference type="ARBA" id="ARBA00048650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="36">
        <source>
            <dbReference type="ARBA" id="ARBA00048691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="37">
        <source>
            <dbReference type="ARBA" id="ARBA00048704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="38">
        <source>
            <dbReference type="ARBA" id="ARBA00048935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="39">
        <source>
            <dbReference type="ARBA" id="ARBA00049019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="40">
        <source>
            <dbReference type="ARBA" id="ARBA00049109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="41">
        <source>
            <dbReference type="ARBA" id="ARBA00049171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="42">
        <source>
            <dbReference type="ARBA" id="ARBA00049263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="43">
        <source>
            <dbReference type="ARBA" id="ARBA00049414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="44">
        <source>
            <dbReference type="ARBA" id="ARBA00049422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="45">
        <source>
            <dbReference type="ARBA" id="ARBA00049449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="46">
        <source>
            <dbReference type="ARBA" id="ARBA00049521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="47">
        <source>
            <dbReference type="ARBA" id="ARBA00049533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="48">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="49">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="50">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="51">
        <source>
            <dbReference type="EMBL" id="KAB0791242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="52">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1796" mass="201410" checksum="78E9ED8881CCFCEE" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A2H1</accession>
    <name>A0A5N4A2H1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Scavenger receptor class B member 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">SR-BI</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PPYR_03323</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <location evidence="1">Caveola</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CD36 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A2H1"/>
    <dbReference type="FunCoup" id="A0A5N4A2H1">
        <property type="interactions" value="362"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A2H1"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005901">
        <property type="term" value="C:caveola"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005044">
        <property type="term" value="F:scavenger receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002159">
        <property type="entry name" value="CD36_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11923:SF110">
        <property type="entry name" value="SCAVENGER RECEPTOR CLASS B MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11923">
        <property type="entry name" value="SCAVENGER RECEPTOR CLASS B TYPE-1 SR-B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01130">
        <property type="entry name" value="CD36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01609">
        <property type="entry name" value="CD36FAMILY"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="451"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00040821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAB0791523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="508" mass="56685" checksum="113AEA47762BDFB0" modified="2020-02-26" version="1">MSKISSALSNRACLGIVAAIALLFVILGIIVAIFFMTWVNLVVQHQIVLKNGSQAFGWWRKPPVTPRISIYVYNVTNADDFLNNGSKPIVEELGPYVYTEAWERMNVTFNDNGTVSYNLQKLYFFSEELSVGSEDDVVVVPNIPMLSATSQSKHAARFLRLAMASIMDILKIKPFVEVSVGQLLWGYEDPLLKLAKDVVPKEQKLPYEEFGLMYNKNRTSPDTLTVFTGATDITKFGLINKWNGMSHYSHWLTDECNSLLASDGSIFPPGITPNTTLYIFDKDLCRRLPLKFQKEVERKDGVPAYRFSPPLDVFANADENPENMCFCPHGPPCAPSGFFNVSLCQFDSPVLLSFPHFYLADDTYRTALEGISPPDPEKHRLYLDVQPMMGTALAARARVQINLAVSQVVDIKQVATFPDIIFPILWFEEAVDGLPEEITNLMRLANQVPPVAHASITGVLFALGGVLLIIAVWRLVRGANRLSSLQLATGHIGPQQSKDVQMNNVNRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A2I4</accession>
    <name>A0A5N4A2I4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PPYR_03344</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A2I4"/>
    <dbReference type="FunCoup" id="A0A5N4A2I4">
        <property type="interactions" value="277"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A2I4"/>
    <dbReference type="OrthoDB" id="3437960at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000557">
        <property type="entry name" value="zinc finger and SCAN domain-containing protein 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000512">
        <property type="entry name" value="zinc finger protein 197 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000688">
        <property type="entry name" value="zinc finger protein 197 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:003737">
        <property type="entry name" value="zinc finger protein 429-like isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002467">
        <property type="entry name" value="Zinc finger protein 51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF44">
        <property type="entry name" value="ZINC FINGER PROTEIN 271-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="101"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="163"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="324"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="352"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="380"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="408"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="436"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="464"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="132"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="185"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAB0791544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="564" mass="62734" checksum="59D1BAF5C907BED0" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A2S6</accession>
    <name>A0A5N4A2S6_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_03430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A2S6"/>
    <dbReference type="InParanoid" id="A0A5N4A2S6"/>
    <dbReference type="OrthoDB" id="6756921at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024402522" evidence="1">
        <location>
            <begin position="20"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0791630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="599" mass="72824" checksum="FFB1AFB4BA0B5167" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A3H5</accession>
    <name>A0A5N4A3H5_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PPYR_03694</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A3H5"/>
    <dbReference type="InParanoid" id="A0A5N4A3H5"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032222">
        <property type="term" value="P:regulation of synaptic transmission, cholinergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030431">
        <property type="term" value="P:sleep"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031424">
        <property type="entry name" value="QVR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050975">
        <property type="entry name" value="Sleep_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33562">
        <property type="entry name" value="ATILLA, ISOFORM B-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17064">
        <property type="entry name" value="QVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024389593" evidence="9">
        <location>
            <begin position="19"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0791894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="115" mass="12870" checksum="D9A40B652B47DD88" modified="2020-02-26" version="1">MYIKTLLITLLLVHAVLARLRCYKCNSSKGHTNCQSGSGVYNGTCPEPPQDVGQTCLEYSENVNGATKYVRKCAIVFWDWVDKKFIPVCSSMKKEGRDILTCFTCTTDHCNGTHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A3T9</accession>
    <name>A0A5N4A3T9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="8">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PPYR_13956</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8">Belongs to the peptidase C12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="8"/>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0791995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A3T9"/>
    <dbReference type="FunCoup" id="A0A5N4A3T9">
        <property type="interactions" value="695"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A3T9"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.532.10">
        <property type="entry name" value="Peptidase C12, ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001578">
        <property type="entry name" value="Peptidase_C12_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036959">
        <property type="entry name" value="Peptidase_C12_UCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057254">
        <property type="entry name" value="UCH_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589:SF17">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01088">
        <property type="entry name" value="Peptidase_C12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00707">
        <property type="entry name" value="UBCTHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00140">
        <property type="entry name" value="UCH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52048">
        <property type="entry name" value="UCH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 8" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4 8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UCH catalytic" evidence="9">
        <location>
            <begin position="2"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0791995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="161" mass="17665" checksum="ADDDD65C54181A18" modified="2020-02-26" version="1">MSLLPLESNPDFLQKLGVPEKWSLVDVFGLDADSLAWVPKPVLSVILLFPISETYQTFAETQANEIKEAGQTVTPDLYYVKQMVSNACGTVALIHSIANNMQQIEIAEGPFKKLLDESKNMTPAERGELLQKSAAAIMDAHRELESEGQTTVSSDLVRANS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A3W0</accession>
    <name>A0A5N4A3W0_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_13939</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0791978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A3W0"/>
    <dbReference type="InParanoid" id="A0A5N4A3W0"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0791978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="152" mass="17567" checksum="8A87359426AF96B0" modified="2020-02-26" version="1">MFCGNCFKFHTSSFWNLHKIVGRSRGRSIQSVRFSRIGYSFMFQNFFGAPCMKFELFVLLLSSLVSCTILVSVTVFDLFAKIANDGNYGYVCASVCAYGRMFLICEFNHHLQLQYTELTINPVIFVFKTSKLTDFQNCKNTKFFEILKIPFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A474</accession>
    <name>A0A5N4A474_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transmembrane protein 135 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_14030</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM135 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A474"/>
    <dbReference type="FunCoup" id="A0A5N4A474">
        <property type="interactions" value="1119"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A474"/>
    <dbReference type="OrthoDB" id="291792at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026749">
        <property type="entry name" value="Tmem135"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031926">
        <property type="entry name" value="TMEM135_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12459:SF15">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12459">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 135-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15982">
        <property type="entry name" value="TMEM135_C_rich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="322"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="357"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="400"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="Transmembrane protein 135 N-terminal" evidence="8">
        <location>
            <begin position="14"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="208"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF15982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0792069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="480" mass="53821" checksum="3D6A09797DB46115" modified="2020-02-26" version="1">MVQVQSKFAPIHINCYEFCHPWTESCLEASVGSYLCAIVDSLRIYTTVYMLALLMKGSVPSKEEIKKTVLGMLQSTAFLSANGMGFTLFLCLLRKLLGHFNFLTVSAIPSFLANFFAILIERPSRRTLLSLYVSNVATETVWNMAVSRDWVRPRNDGVVVIFSVCMAILLTYFKSGLHKRDGERVDSMFGVLRLIVGPYEEKSISRPSEVNTFHREQTRNDPLSSGSRWSVPGGRSSANNTYRLITQALRIYRRLINKIKCLNRNPACPHPFSCVHYTLQGACKMAGVGLSIQLALSFVFNLKSIFLSPRAIKTIVWKKKTLSLAIFLGGFSGLFRGICCVLRNVTGTDSACHAIPAALIAGIAFKQYPDTTVALYVMWKMAQISYGLGIERGIVPRVPGFTIFLYCVSTAILFHTALLEPVNLRPSYWKFLHSISAGRVATMNREPLDVWGLETSRQLVEVLRNTHTRRGVKYYVSNFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A4A0</accession>
    <name>A0A5N4A4A0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TNase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_00511</name>
        <name evidence="1" type="ORF">PPYR_14098</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A4A0"/>
    <dbReference type="FunCoup" id="A0A5N4A4A0">
        <property type="interactions" value="50"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A4A0"/>
    <dbReference type="OrthoDB" id="6220511at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042421">
        <property type="entry name" value="C3orf33-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28434">
        <property type="entry name" value="PROTEIN C3ORF33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28434:SF1">
        <property type="entry name" value="PROTEIN C3ORF33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0792137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0803541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="231" mass="26133" checksum="EB28B30291FA3B3A" modified="2020-02-26" version="1">MTTYKDKINDKFNQFTSIMEANTRGVKISCYSIALLGLTVAVRRVRPFSRFKRPSDIPSHFIKESRELTGTVEGVDPTKGLLLINHKPLLELPFTSPGALPVKLSGVHVKGHGISWLQAIVRGSQVKFIPVLKEKDWVQSEVSLDQLAYDKKWKTINVAESLVGIGFADMETPAIGSKRYCQQLHTAEIQAERKRLGLRYYVKPTREFVLKLGRTMYHFFASRTAKVVAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A4I8</accession>
    <name>A0A5N4A4I8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Alpha-mannosidase</fullName>
            <ecNumber evidence="11">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PPYR_14195</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides.</text>
            <dbReference type="EC" id="3.2.1.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the glycosyl hydrolase 38 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="11"/>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A4I8"/>
    <dbReference type="FunCoup" id="A0A5N4A4I8">
        <property type="interactions" value="132"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A4I8"/>
    <dbReference type="OrthoDB" id="2016903at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004559">
        <property type="term" value="F:alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10810">
        <property type="entry name" value="GH38N_AMII_LAM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.50:FF:000002">
        <property type="entry name" value="Alpha-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.50:FF:000003">
        <property type="entry name" value="Alpha-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1180:FF:000018">
        <property type="entry name" value="Alpha-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.30:FF:000003">
        <property type="entry name" value="Alpha-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.110.10:FF:000001">
        <property type="entry name" value="Alpha-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.110.10">
        <property type="entry name" value="Glycoside hydrolase 38, N terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.50">
        <property type="entry name" value="Glycoside hydrolase family 38, central domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.30">
        <property type="entry name" value="Golgi alpha-mannosidase II, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041147">
        <property type="entry name" value="GH38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011682">
        <property type="entry name" value="Glyco_hydro_38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015341">
        <property type="entry name" value="Glyco_hydro_38_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037094">
        <property type="entry name" value="Glyco_hydro_38_cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000602">
        <property type="entry name" value="Glyco_hydro_38_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027291">
        <property type="entry name" value="Glyco_hydro_38_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028995">
        <property type="entry name" value="Glyco_hydro_57/38_cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050843">
        <property type="entry name" value="Glycosyl_Hydrlase_38"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048534">
        <property type="entry name" value="Man2a1-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11607">
        <property type="entry name" value="ALPHA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11607:SF3">
        <property type="entry name" value="LYSOSOMAL ALPHA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09261">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17677">
        <property type="entry name" value="Glyco_hydro38C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07748">
        <property type="entry name" value="Glyco_hydro_38C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01074">
        <property type="entry name" value="Glyco_hydro_38N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21260">
        <property type="entry name" value="Laman-like_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00872">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88688">
        <property type="entry name" value="Families 57/38 glycoside transferase middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <keyword evidence="7 11" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024462511" description="Alpha-mannosidase" evidence="11">
        <location>
            <begin position="20"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 38 central" evidence="12">
        <location>
            <begin position="367"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAB0792236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1040" mass="118726" checksum="B69D3F59890A4FA8" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A5G4</accession>
    <name>A0A5N4A5G4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PPYR_14522</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A5G4"/>
    <dbReference type="FunCoup" id="A0A5N4A5G4">
        <property type="interactions" value="173"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A5G4"/>
    <dbReference type="OrthoDB" id="6376512at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000258">
        <property type="entry name" value="G-protein coupled receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22752">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="66"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="186"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="283"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="45"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAB0792563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="336" mass="38126" checksum="1DC03617621A4E8B" modified="2020-02-26" version="1">MFRASDTSTMIILSDADDDTELVFTLESLTQAGIIFIMGIAIIVTNVLIIATFLNFRGHAEVINCYLLSLAVADLLCGLLVVPLSVYPALVQRWVYGDILCSLVGYLEVTLWAVTVYTFMWISVDRYLAVRKPLRYETIQTKTRCQCWMAFTWISAAMLCCPPLLGLEKPVFDHDGHICMLDWGTMAAYTATLAILVLGPSLITIVYTYGYIFNTMRKLRNGAPLHDKEYVTALSENLSNPSHIMSFVLVVTFWFSWTPYLGVKLYEYFTGIKFQVPFLHFGIVWLGFLNSFWKSLILVSLSPQFRLALRIFCMSICCRYKGGRMQAELIGMDVDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A5Y4</accession>
    <name>A0A5N4A5Y4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">snRNA-activating protein complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_14670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A5Y4"/>
    <dbReference type="InParanoid" id="A0A5N4A5Y4"/>
    <dbReference type="OrthoDB" id="20127at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019185">
        <property type="term" value="C:snRNA-activating protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042795">
        <property type="term" value="P:snRNA transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042796">
        <property type="term" value="P:snRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019188">
        <property type="entry name" value="SNAPC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15131">
        <property type="entry name" value="SMALL NUCLEAR RNA ACTIVATING COMPLEX, POLYPEPTIDE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15131:SF3">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09808">
        <property type="entry name" value="SNAPC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0792711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="281" mass="32708" checksum="CCD37E86A24677DC" modified="2020-02-26" version="1">MASNLVKESYSVNKQQYVSYHIQIASAFQTDCERLLVTFESEVDLSFKMFASVWREMHFSSIFNDIELVEELRFFIESCFTTIQKYLVFCERIGVKVGAFYMLYCLYWRQPSKNKIRIRCTAEVFRHISNLVDRMQEEGAYDVPYLFQQLKFNDAFKLVIFPNVYALEGRFMWQEKELQNDIFKEIKRGDPLLQTETVLHSQEFYGLNNICTVASDYVEGLRKYGISEKVCEAVTNLPGELEAILNQMESCVEGSESNVTESKAKQLKGKAFTSKVSCFKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A7F9</accession>
    <name>A0A5N4A7F9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sulfotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_12862</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfotransferase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A7F9"/>
    <dbReference type="SMR" id="A0A5N4A7F9"/>
    <dbReference type="InParanoid" id="A0A5N4A7F9"/>
    <dbReference type="OrthoDB" id="205623at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11783">
        <property type="entry name" value="SULFOTRANSFERASE SULT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="3">
        <location>
            <begin position="57"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0793242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="327" mass="38253" checksum="84C7721D458A08B4" modified="2020-02-26" version="1">MLPITKIPESRIKKTIQINYRSDLEDFLMLFGEEQTCLPSITQKFATEIDNFAVRNDDVIVASFPKAGTTWTQEMVWSIKNRANFEGASLNIYQRFPMLEACGLPSLLTTGEPFILNSLEYLGQIKGQRLIKTHLPFSLLPKDIQLQRKSPKIIYVVRNPKDVFISYFNHTRIIDGFKGNLEDFADLFLSDSVVFAPFWKHVFGFYNRKDLPNVLILKYEDMKKNLKSEIVRVSQFLEEKPLTDDELTLIGRRLDFNFMKNNPSVNHQCFSDEMKRKNHQLEGDFMKSGSVGGYKREMTDEMVQKFDRWIEENITDTELYEKYWFGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A7Q9</accession>
    <name>A0A5N4A7Q9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed RNA polymerase</fullName>
            <ecNumber evidence="3">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PPYR_12987</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">1611_PpyrPB1</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="3"/>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A7Q9"/>
    <dbReference type="InParanoid" id="A0A5N4A7Q9"/>
    <dbReference type="OrthoDB" id="10248617at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000008">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000016">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1110.10:FF:000007">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1100.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1110.10">
        <property type="entry name" value="RNA polymerase Rpb2, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037034">
        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009674">
        <property type="entry name" value="Rpa2_dom_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06883">
        <property type="entry name" value="RNA_pol_Rpa2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RNA polymerase beta subunit protrusion" evidence="14">
        <location>
            <begin position="28"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="13">
        <location>
            <begin position="190"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="15">
        <location>
            <begin position="450"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase I subunit RPA2" evidence="16">
        <location>
            <begin position="560"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF06883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAB0793367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="658" mass="74520" checksum="D1C577560ABE8ADD" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2024-03-27" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A7U5</accession>
    <name>A0A5N4A7U5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Metalloendopeptidase</fullName>
            <ecNumber evidence="2">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_13010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="2"/>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A7U5"/>
    <dbReference type="InParanoid" id="A0A5N4A7U5"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF850">
        <property type="entry name" value="METALLOENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M12A" evidence="3">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0793390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="103" mass="11755" checksum="DA79456EDDBA2406" modified="2020-02-26" version="1">MHAVGFQHQHSSPDRDNYIWIMYENIVDDQYGSFNKIQDVTPFGQPYDLCTIMHYTEYAFSKNNQPTIVAKSNPGCVIGGAPGQGLTQIDKNKINYMYHCYGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2024-03-27" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A8Z3</accession>
    <name>A0A5N4A8Z3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tyr recombinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_13379</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A8Z3"/>
    <dbReference type="InParanoid" id="A0A5N4A8Z3"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35617:SF3">
        <property type="entry name" value="CORE-BINDING (CB) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35617">
        <property type="entry name" value="PHAGE_INTEGRASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0793759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="199" mass="22805" checksum="8EBE1769C26689C2" modified="2020-02-26" version="1">MISSLSTATINQYSVHWKNWVSFCCAQKTTPFNNKVNMIIEFLTNMFHNNSSYTSINTARSAISLITGNTLGEHENLKRFMKGIHNLRPSKPKYNDTWDPKIVLEHLQTLHPNDSISLEMLSSNRWVKIIFEKSGINCKYTPYSIRHASTSLAKRQGVPLELIKKVAGWSPISTTFSKFYDRPLDNNDRFAKTVLSSQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AA06</accession>
    <name>A0A5N4AA06_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_13773</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0794153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AA06"/>
    <dbReference type="FunCoup" id="A0A5N4AA06">
        <property type="interactions" value="756"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AA06"/>
    <dbReference type="OrthoDB" id="10045710at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00052">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000261">
        <property type="entry name" value="EH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216">
        <property type="entry name" value="EH DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216:SF174">
        <property type="entry name" value="GH06923P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12763">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00027">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50031">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EH" evidence="3">
        <location>
            <begin position="220"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="253"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="129"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="305"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="422"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="604"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="131"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0794153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="652" mass="73827" checksum="05382F5BFBCF74B8" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AB05</accession>
    <name>A0A5N4AB05_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PPYR_11330</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0794491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AB05"/>
    <dbReference type="FunCoup" id="A0A5N4AB05">
        <property type="interactions" value="31"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AB05"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000040">
        <property type="entry name" value="T-cell leukemia homeobox protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042247">
        <property type="entry name" value="TLX1/2/3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45921:SF6">
        <property type="entry name" value="C15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45921">
        <property type="entry name" value="IP01054P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="9">
        <location>
            <begin position="173"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="175"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0794491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="302" mass="33389" checksum="5F70294FA3A28D91" modified="2020-02-26" version="1">MSDHELMEDDHEINVLDTDSRLSNSDSEPRSSRSHCSSPETVPNSHSSTTTTLPFSISNLLGKHLEDKSEPESPEISTHLSYHPHGLPPPRGVGAFIPSGYYGQGVLRVPAHRPVGGPTSPGTVFNPWALSLDPVLQRSAAAAAFASQVVKERLSAFPMVRRIGHPYQNRTPPKRKKPRTSFTRLQIAELEKRFHKQKYLASAERAALAKSLKMTDAQVKTWFQNRRTKWRRQTAEEREAERQAANRLMLSLQAEALSKGYMPEAPPSSTGPGDTALSALQNLQPWAGPYNTPQPALAESIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ABC3</accession>
    <name>A0A5N4ABC3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Annexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PPYR_11450</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="domain">
        <text evidence="6">A pair of annexin repeats may form one binding site for calcium and phospholipid.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the annexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0794611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ABC3"/>
    <dbReference type="InParanoid" id="A0A5N4ABC3"/>
    <dbReference type="OrthoDB" id="37886at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012506">
        <property type="term" value="C:vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.10:FF:000001">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.10:FF:000002">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.10:FF:000004">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.10:FF:000010">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.10">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001464">
        <property type="entry name" value="Annexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018502">
        <property type="entry name" value="Annexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018252">
        <property type="entry name" value="Annexin_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037104">
        <property type="entry name" value="Annexin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502">
        <property type="entry name" value="ANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502:SF102">
        <property type="entry name" value="ANNEXIN B11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00191">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00196">
        <property type="entry name" value="ANNEXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00335">
        <property type="entry name" value="ANX"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47874">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00223">
        <property type="entry name" value="ANNEXIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51897">
        <property type="entry name" value="ANNEXIN_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0041">Annexin</keyword>
    <keyword evidence="3 6" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 6" id="KW-0111">Calcium/phospholipid-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="18"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="65"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="76"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0794611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="457" mass="49747" checksum="A7E3340A6AB9C606" modified="2020-02-26" version="1">MSYPGYPPYQQGPGMPGANPPYPQQGYPPYPGGGGAPYPGAYPPQGVYPPSLGFSSNAPMYMPQPSYPGAPPPEGSYPSAEPSYPGAAPSYPGAASQPPYAGAQQVYPTHHTPNYAPPPPTSHDNYEPPHGGYSSQPEVVQRKSPTVIPASPFDPRGDAEVLRKAMKGFGTDEKAIINVLARRTNAQRLEIAVQFKTMYGKDLIKDLKSELSGRFEDLIVALMLPLPQYYARELYNAVSGMGTDEDCLIEVLCTLSNHEIMTIRTAYQNTYHSSLESDLRGDTSGHFKRLMTALCSAGRDESGVVNQAHASADAQQLLNAGALQWGTDESLFNMILCSRNYNQLRLIFDEYQRIAGHDIEQAIKGEFSGDIEQGLLAVVRAIRSLPAFFAKRLYQSMVGMGTNDNQLIRIIVTRSEVDMGEIKQHYAAMYGKDLAAAIADDVSGDYKKCLLALIGAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ABP5</accession>
    <name>A0A5N4ABP5_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_11589</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0794750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4ABP5"/>
    <dbReference type="OrthoDB" id="6781668at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13857">
        <property type="entry name" value="Ank_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="55"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="7"/>
    </dbReference>
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        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="26"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="35"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1037"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1070"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1153"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1186"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1219"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1252"/>
            <end position="1284"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1285"/>
            <end position="1317"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1351"/>
            <end position="1383"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1415"/>
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    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1448"/>
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    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1481"/>
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    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1517"/>
            <end position="1549"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1550"/>
            <end position="1583"/>
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            <end position="1903"/>
        </location>
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        <location>
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        <location>
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            <end position="2815"/>
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        <location>
            <begin position="2815"/>
            <end position="2847"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="2848"/>
            <end position="2880"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0794750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="2913" mass="324554" checksum="95D03AF174B8BE8F" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ACS5</accession>
    <name>A0A5N4ACS5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PPYR_11950</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">1611_PpyrPB1</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0795111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ACS5"/>
    <dbReference type="InParanoid" id="A0A5N4ACS5"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000119">
        <property type="entry name" value="Putative map kinase-interacting serine/threonine-protein kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000093">
        <property type="entry name" value="Putative map kinase-interacting serine/threonine-protein kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050205">
        <property type="entry name" value="CDPK_Ser/Thr_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24349">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 15" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="100"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="34"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="62"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAB0795111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="494" mass="54757" checksum="ECE3D69B4642E8E0" modified="2020-02-26" version="1">MASLKELSLSESDNCQPRFDDDFCDVQDLGRDNGVAGTNSLNGNGYGGGGGSASDSSDQMDSDARARELARRKEEAKRKRRKKKRTGSSLVSSCFQDLYKLTGEILGEGAYASVQTCLNMYTDQEFAVKIIEKVPGHARARVFREVDTFHHCQGHPNIIQLIEFFEDEEKFYLVFEKVNGGQLLRRIQEHKFFSEAAAAEIIQEIASALSFMHGKGIAHRDLKPENILCVHPDRLCPVKICDLDLGSGIRFQASVSSPLATPQLLTPVGSAEFMAPEVVEAFIGEADTTTYDKRCDLWSLGVIMYILLCGYPPFYGKCGGDCGWERGDNCSACQDLLFHSIQEGRYEFPEQEWGHISAEAKHLISSLLVKTASQRIGASEVLRHPWLTRACDNLHLATPEVIKRNNSVRELSQFAESAMVCNRVVLQHFSMNLDYLERPNVYPFSSPPPLGLSPPSESKLLQRRTAAATKTHNSCQFLHLTHSPSATAIASPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ACW1</accession>
    <name>A0A5N4ACW1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Elongation of very long chain fatty acids protein</fullName>
            <ecNumber evidence="10">2.3.1.199</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Very-long-chain 3-oxoacyl-CoA synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PPYR_11995</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:32727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="ChEBI" id="CHEBI:90736"/>
            <dbReference type="EC" id="2.3.1.199"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ELO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.199" evidence="10"/>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0795156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ACW1"/>
    <dbReference type="InParanoid" id="A0A5N4ACW1"/>
    <dbReference type="OrthoDB" id="434092at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF69">
        <property type="entry name" value="ELONGATION OF VERY LONG CHAIN FATTY ACIDS PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="205"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0795156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="296" mass="35075" checksum="563401B4347957EB" modified="2020-02-26" version="1">MSLLLQYVEDFHAQVDKLGDPRVANWFLMSSPFPTLAICSLYAYGVKVWGPKLMEHRKPFELKNVLIAYNLFQVIISFWLFYQGGMAGWLTGLYNYRCQPVDYSDDPTAVWMAHLCWYYYMSKFTEFLDTIFFVMRKKFDQISTLHVIHHTIMPMFSWLGVKIVPGGHSTFFGFLNSFVHTIMYSYYLLSALGPQMQKYLWWKKYITTLQIVQFVCILVHALQVLFMECDYPHAFVWVLALNSVLFIFLFRSFYNEAYNRKATKKTKEGRDIHSKQLKQDDLDNNAKYIQTKRNAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AD46</accession>
    <name>A0A5N4AD46_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PPYR_12048</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Trehalose transporter subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0795209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AD46"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000218">
        <property type="entry name" value="facilitated trehalose transporter Tret1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000055">
        <property type="entry name" value="Facilitated trehalose transporter Tret1-2 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050549">
        <property type="entry name" value="MFS_Trehalose_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021:SF46">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="309"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="343"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="378"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="412"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="517"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="542"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="574"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="599"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="680"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="718"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="743"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="777"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="840"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="977"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1003"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1036"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1182"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1208"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1242"/>
            <end position="1266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1278"/>
            <end position="1301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1307"/>
            <end position="1329"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="10"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="437"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="909"/>
            <end position="1333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAB0795209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1367" mass="149617" checksum="D504CFF6992EC047" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AD87</accession>
    <name>A0A5N4AD87_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Intraflagellar transport protein 20 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_12129</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0795290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AD87"/>
    <dbReference type="FunCoup" id="A0A5N4AD87">
        <property type="interactions" value="47"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AD87"/>
    <dbReference type="OrthoDB" id="10254896at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097546">
        <property type="term" value="C:ciliary base"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030990">
        <property type="term" value="C:intraciliary transport particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097730">
        <property type="term" value="C:non-motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061512">
        <property type="term" value="P:protein localization to cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028172">
        <property type="entry name" value="FT20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31978">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31978:SF1">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14931">
        <property type="entry name" value="IFT20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0966">Cell projection</keyword>
    <keyword evidence="2 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="77"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0795290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="130" mass="15077" checksum="72039E6D0B080C5D" modified="2020-02-26" version="1">MDNLSKLGIYFDEIDKVRILEPEVSNQTNDLKEECKIYVEKISEFQKISDGFLSITTNLANEVEKQKMKAIGARNLLQSMTKEKEAQCQQLQALISEKSMELERLKVQLTSLQKIEMEQNEIINRLTHSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ADN0</accession>
    <name>A0A5N4ADN0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PPYR_12238</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0795399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ADN0"/>
    <dbReference type="InParanoid" id="A0A5N4ADN0"/>
    <dbReference type="OrthoDB" id="10034726at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071880">
        <property type="term" value="P:adenylate cyclase-activating adrenergic receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15331">
        <property type="entry name" value="7tmA_5-HT1A_invertebrates"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248:SF200">
        <property type="entry name" value="5-HYDROXYTRYPTAMINE RECEPTOR 1B-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="105"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="256"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="287"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="1"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="196"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAB0795399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="341" mass="38204" checksum="FA68D4F1EFF2A28B" modified="2020-02-26" version="1">MPLGAVYEVSQEWTLGPELCDMWTSSDVLCCTASILHLVAIALDRYWAVTNIDYIHHRTAKRIGVMIAVVWFVSFLVCIAPLLGWKDPGWAGRLEDKKCIVSQDIGYQIFATSSSFYLPLMVILILYWRIFQTARKRIRRRQASYGATSSGNQNPAAGGIAGGLAVASGTGGIAAAVVTIIGRPLPTISETTTAFTTVSSNSNNTSPEKTSFPNGLEPEPTTTDFGAINYQPQYYAIKRKKDSADSKRERKAAKTLAIITGAFVICWLPFFIMAVLLPIYKDFFKEYIISLFLWLGYFNSTLNPIIYTIFSPEFRHAFKKILFGRNYARRRNRKFGIKNLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ADU0</accession>
    <name>A0A5N4ADU0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Tyrosine decarboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PPYR_12332</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the group II decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0795493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ADU0"/>
    <dbReference type="FunCoup" id="A0A5N4ADU0">
        <property type="interactions" value="24"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4ADU0"/>
    <dbReference type="OrthoDB" id="639767at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06450">
        <property type="entry name" value="DOPA_deC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1340.10:FF:000001">
        <property type="entry name" value="Histidine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000025">
        <property type="entry name" value="Histidine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000018">
        <property type="entry name" value="Histidine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1340.10">
        <property type="entry name" value="dopa decarboxylase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010977">
        <property type="entry name" value="Aromatic_deC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021115">
        <property type="entry name" value="Pyridoxal-P_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999">
        <property type="entry name" value="GROUP II PYRIDOXAL-5-PHOSPHATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999:SF70">
        <property type="entry name" value="MIP05841P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00800">
        <property type="entry name" value="YHDCRBOXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00392">
        <property type="entry name" value="DDC_GAD_HDC_YDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="590"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="6">
        <location>
            <position position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0795493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="635" mass="71491" checksum="3061BA10DD5A53F4" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AFB7</accession>
    <name>A0A5N4AFB7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Armadillo repeat-containing protein 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_10086</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AFB7"/>
    <dbReference type="InParanoid" id="A0A5N4AFB7"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000061">
        <property type="entry name" value="armadillo repeat-containing protein 8 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000070">
        <property type="entry name" value="armadillo repeat-containing protein 8 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038739">
        <property type="entry name" value="ARMC8/Vid28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15651">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15651:SF7">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ARM" evidence="8">
        <location>
            <begin position="57"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="7">
        <location>
            <begin position="58"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0796025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="655" mass="72430" checksum="C026ECFB83ADD8B1" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AGG6</accession>
    <name>A0A5N4AGG6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Palmitoyl-protein thioesterase 1</fullName>
            <ecNumber evidence="2">3.1.2.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Palmitoyl-protein hydrolase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PPYR_10496</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19233"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="3.1.2.22"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:19234"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the palmitoyl-protein thioesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.22" evidence="2"/>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AGG6"/>
    <dbReference type="InParanoid" id="A0A5N4AGG6"/>
    <dbReference type="OrthoDB" id="10263094at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006898">
        <property type="term" value="P:receptor-mediated endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000107">
        <property type="entry name" value="Palmitoyl-protein thioesterase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002472">
        <property type="entry name" value="Palm_thioest"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11247:SF8">
        <property type="entry name" value="PALMITOYL-PROTEIN THIOESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11247">
        <property type="entry name" value="PALMITOYL-PROTEIN THIOESTERASE/DOLICHYLDIPHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02089">
        <property type="entry name" value="Palm_thioest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00414">
        <property type="entry name" value="PPTHIESTRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024461546" description="Palmitoyl-protein thioesterase 1" evidence="10">
        <location>
            <begin position="18"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0796435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="293" mass="32698" checksum="0F66E178E5EBDFB0" modified="2020-02-26" version="1">MKSLAIFAVLLLSNISATPTPAPIPVVLWHGMGDNANGPGMNRVKQLIENEIPGTYVKSLMIGGNIITDTINGFLMHPTDQVEYACNLIQSDPNLAQGYYGIGFSQGSQFIRALGQRCSTPKMKGLISIGGQQQGVYGIPFCNPDFLEFCGAIRPIVTHFAYESFQFLVQATYWHDALNSTDYAHRNTFMADINNELHINQTYVDNLQALEKFVMVKFEQDGMVIPIESQWFGFYKPGQGTVTESLQESKVYTRLGLDKLGSEGKLHFLSCPGLHLQFTPEWFVEHIIKAHLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AGN3</accession>
    <name>A0A5N4AGN3_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_10510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AGN3"/>
    <dbReference type="InParanoid" id="A0A5N4AGN3"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="172"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0796449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="198" mass="22372" checksum="C206C5E31FEE5093" modified="2020-02-26" version="1">MVRYSSSQSPPGWKAGSTENRNGRSGAYVCVKQPWRCAVHYSKSLVNWNGVIDWRARKMVHSDMLRAQWRRAQLLATHFWNRVLRLLLEPVVVPTRVRFPFGVRRTLYGVNCVGVGGVVGIGEAASERDGFDCTARMRIRIVSSELGVLPIASRHLAFNCCRASWITLDAPVLMVFVVCVFVYSFYITVICTVVFITK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AHX0</accession>
    <name>A0A5N4AHX0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_11003</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AHX0"/>
    <dbReference type="InParanoid" id="A0A5N4AHX0"/>
    <dbReference type="OrthoDB" id="8300214at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861:SF1">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="34"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0796942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="266" mass="30918" checksum="41FF07BE182BC2F5" modified="2020-02-26" version="1">MYKAQSFRMHSLLAQRDARYGIEKIKRIVTWRPQCNVLDIGCGTGNVTHDVLLPILPKSTNSIIGVDKLTEFIQYASEQYGKKIVFEQMDIANCQIPGTDYEGHFDYIFSFYCLHFVGEQELALRNIYRLLKPSGDFFFTCFVKCNLFEAIRFLAGTEKWKPSMSEYHKYLCPYQFSSDPIIDLERMLLKIGFKVLQLSIEPKDIMLPTESASAFMFSHSPIELPLDFPSACLDVLREWNDVHTKEDNKEYCCLKYHMIFGYVAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AID7</accession>
    <name>A0A5N4AID7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Amine oxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_08114</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AID7"/>
    <dbReference type="InParanoid" id="A0A5N4AID7"/>
    <dbReference type="OrthoDB" id="5046242at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046592">
        <property type="term" value="F:polyamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050281">
        <property type="entry name" value="Flavin_monoamine_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742:SF398">
        <property type="entry name" value="AMINE OXIDASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742">
        <property type="entry name" value="FLAVIN MONOAMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024355714" description="Amine oxidase domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="Amine oxidase" evidence="2">
        <location>
            <begin position="31"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0797120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="484" mass="54129" checksum="F8C2F3F581936AD6" modified="2020-02-26" version="1">MRSILAVLIALTLSVECRKEPRIVIIGAGAAGIAAASTLSRNGFTNVTILEADGRVGGRIYSLRFGKSLIDLGAQWCHGEKNNVVYEMVRDLQVLKVDDTSPELYHSTLKRVDSKFNARLNRLFEDVYFADNYGAEGSLGEVLTERYEAEIRKIWKNKDELTLAEECLDLFERYVESELGSFSWSTVATSVDFEPCEGSQVLGWNGLGFKTILGVLMRQASGPIERNIALNKSVSGISLESGKVRVSCSDLSSYTADHVIWTPSLGVLKHLHANVFKPNLPKEKVRAIDTLGIDGIMKVFLHFPARWWDDNFEGVAFVWRQADLKNSSLEYPEGPKIGNRSWITTIYCTIPLQENPNVLLVWFIGPLVPEIEQLSDETIANGAMHVMRKFLSKDYPSISHPDQITRKNWYSDPNFRGTYSFETVHSRKLGRSQAAVLAEPIRAADGKPVIMFAGEATSTNHYSTVHGAIETGFREANRIIELYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AK66</accession>
    <name>A0A5N4AK66_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_08666</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AK66"/>
    <dbReference type="InParanoid" id="A0A5N4AK66"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0797673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="144" mass="16243" checksum="DA1FA3F856656248" modified="2020-02-26" version="1">MRKFIHPPYSTTAPTAPLGFDSQHQQIPLYPMNQGLQQPPFQQYDNRGQPPPLNAYNAVPTVPVTYFAQPQQTIVALNSTPRAYQPIPRFGITNRKHQYIALGIFGGIFLVMVIIGIVIGVVVSRDISESNRRHEEFRKKLSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AKQ7</accession>
    <name>A0A5N4AKQ7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Spaetzle domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_08887</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AKQ7"/>
    <dbReference type="FunCoup" id="A0A5N4AKQ7">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AKQ7"/>
    <dbReference type="OrthoDB" id="10055432at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41153">
        <property type="entry name" value="RE41427P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41153:SF2">
        <property type="entry name" value="RE41427P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024353263" description="Spaetzle domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0797894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="236" mass="25643" checksum="3D8604386B6C61FA" modified="2020-02-26" version="1">MDKNICSCLIAVIVCYATYTYATHATKCEGASGLKYLWGDALSDSHDCIGPNNLPYPSSAINRSFRSTNLWSGSSRTGRSQKTIDPFITRKALLSAYELNSGVGEPSTISRTARAAGTTQTSCFSTPSRLCKTRYNTTAPLYGVSLTSGQPVTIVQKFPDLLQQVVFEVCESSECDVVRGECTQTYVPYLFLVIPLGPVTLTGQDYVLVESGCVCRPKYASHTNQEANAMTSIPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ALF5</accession>
    <name>A0A5N4ALF5_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PPYR_09129</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">1611_PpyrPB1</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PIEZO (TC 1.A.75) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A5N4ALF5">
        <property type="interactions" value="347"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4ALF5"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027272">
        <property type="entry name" value="Piezo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031334">
        <property type="entry name" value="Piezo_cap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056770">
        <property type="entry name" value="Piezo_THU9_anchor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056769">
        <property type="entry name" value="Piezo_TM1-24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031805">
        <property type="entry name" value="Piezo_TM25-28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056768">
        <property type="entry name" value="THU_Piezo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47049">
        <property type="entry name" value="PIEZO-TYPE MECHANOSENSITIVE ION CHANNEL HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47049:SF2">
        <property type="entry name" value="PIEZO-TYPE MECHANOSENSITIVE ION CHANNEL HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12166">
        <property type="entry name" value="Piezo_cap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24874">
        <property type="entry name" value="Piezo_THU9_anchor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24871">
        <property type="entry name" value="Piezo_TM1-24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15917">
        <property type="entry name" value="Piezo_TM25-28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23188">
        <property type="entry name" value="THU_Piezo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="17"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="195"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="444"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="478"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="598"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="623"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="649"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="704"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="804"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="830"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="853"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="910"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1021"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1154"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1199"/>
            <end position="1220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1474"/>
            <end position="1496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1573"/>
            <end position="1599"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1605"/>
            <end position="1624"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1631"/>
            <end position="1651"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1679"/>
            <end position="1697"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1831"/>
            <end position="1853"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1873"/>
            <end position="1892"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1904"/>
            <end position="1923"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1935"/>
            <end position="1952"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="2044"/>
            <end position="2067"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="2314"/>
            <end position="2335"/>
        </location>
    </feature>
    <feature type="domain" description="Piezo TM1-24" evidence="16">
        <location>
            <begin position="26"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="domain" description="Piezo TM25-28" evidence="14">
        <location>
            <begin position="1129"/>
            <end position="1403"/>
        </location>
    </feature>
    <feature type="domain" description="Piezo transmembrane helical unit" evidence="15">
        <location>
            <begin position="1586"/>
            <end position="1704"/>
        </location>
    </feature>
    <feature type="domain" description="Piezo THU9 and anchor" evidence="17">
        <location>
            <begin position="1829"/>
            <end position="2066"/>
        </location>
    </feature>
    <feature type="domain" description="Piezo non-specific cation channel cap" evidence="13">
        <location>
            <begin position="2103"/>
            <end position="2399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1439"/>
            <end position="1460"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="1319"/>
            <end position="1353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF12166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF15917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF23188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF24871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF24874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAB0798136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="2415" mass="278124" checksum="DD5402B934B70F84" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ALK4</accession>
    <name>A0A5N4ALK4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 9">Mannose-P-dolichol utilization defect 1 protein homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PPYR_09222</name>
        <name evidence="12" type="ORF">PPYR_09228</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 9">Belongs to the MPDU1 (TC 2.A.43.3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ALK4"/>
    <dbReference type="FunCoup" id="A0A5N4ALK4">
        <property type="interactions" value="743"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4ALK4"/>
    <dbReference type="OrthoDB" id="271506at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009312">
        <property type="term" value="P:oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000031">
        <property type="entry name" value="Mannose-P-dolichol utilization defect 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000006">
        <property type="entry name" value="mannose-P-dolichol utilization defect 1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016817">
        <property type="entry name" value="MannP-dilichol_defect-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12226">
        <property type="entry name" value="MANNOSE-P-DOLICHOL UTILIZATION DEFECT 1 LEC35 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12226:SF2">
        <property type="entry name" value="MANNOSE-P-DOLICHOL UTILIZATION DEFECT 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF023381">
        <property type="entry name" value="MannP-dilichol_defect-1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="100"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00067517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR023381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0798229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAB0798235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="239" mass="26508" checksum="8590E5FD31E20952" modified="2020-02-26" version="1">MDLFRKVTSIVLTPECYDEYFVEFNFFSAPCFKTTLSKCLGVLLILGAVLVKVPQIIKIFKSKSAVGISISSVTLDLVAITIFLSYSFVKGFPFTSYGDALFLAIQTLIVGVLVLYYSGSPSNATIYTIGYLITCFIMMSGITPIGILWTLQGFNIPILLTGKLTQAYTNYKNGTTGQLSAVTLIMLFGGSLARIFTSIQETGDFMIILTYLVSSSANFVLVFQLWYYWDVELSKKKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AMX1</accession>
    <name>A0A5N4AMX1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CUB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_09698</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AMX1"/>
    <dbReference type="InParanoid" id="A0A5N4AMX1"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024438627" description="CUB domain-containing protein" evidence="3">
        <location>
            <begin position="19"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="4">
        <location>
            <begin position="120"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0798705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="304" mass="34384" checksum="34B1BB29EAB38758" modified="2020-02-26" version="1" fragment="single">MWFKIGLLLILVTEEVRGYIEYVETSGCESCVLRLTCRHLNSIISVLEANFEVIESYINETLPTPFPPMHPRIALNQRCSGVNHCSFILTKDCPGADKWGLGNLTVNYACISEDRLTKYCNKEILLASPETFGISRGFIHNPGYPRFYLGKQKCRWTIHAPPLQRVKVTIYDISLVADPNLSKCSDIVEVSDRGQILYSTCEQHEPPLEITSLDDTLDVTLIPSPKENLLPRRGIMFYYTAVGCSTPIAPKDGYLVYRNDTVAEYSCCVGYAFPDTRIRSRIIKCLGYRWNTTVPLPDCKCKCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AN13</accession>
    <name>A0A5N4AN13_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF5641 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_09689</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AN13"/>
    <dbReference type="InParanoid" id="A0A5N4AN13"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040676">
        <property type="entry name" value="DUF5641"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF5">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18701">
        <property type="entry name" value="DUF5641"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase zinc-binding" evidence="1">
        <location>
            <begin position="209"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5641" evidence="2">
        <location>
            <begin position="275"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0798696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="359" mass="40615" checksum="636C205C2C87358F" modified="2020-02-26" version="1">MVPTASAPFLAVRCLVELANECKENFPAVNDLLTGVESINDALQIQKCLSRILSKAGFELRKWLSNNSAILKRFEISKGLDQGIIQIALTVQTENCLNTIIKNFSKVTKIVRIVAYVVRFIKNSKLRKDSRNYGVLAPDELDHALYSLINVCFPLEYSCLTKGISLKSSSKILSLNPYLHNNLIRVGGRISNSKQCFDQIHPIILPKNHILTELIIKHEHERLLHAGAQMVLSSLREKYWPISGRHLCKKIIRNCVKCFKAYPKSSNYLMGNLPEKEYLSELQTRVKWKENCTNLIGIDSLVLLKEDHVSPLNWPLGRVVKLYPGQDGVTRVVEIKVRGGVVKRAINRVCVLPIEHNVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AN35</accession>
    <name>A0A5N4AN35_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ETS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_06642</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the ETS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0798762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AN35"/>
    <dbReference type="FunCoup" id="A0A5N4AN35">
        <property type="interactions" value="364"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AN35"/>
    <dbReference type="OrthoDB" id="6408625at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000516">
        <property type="entry name" value="ets DNA-binding protein pokkuri"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000061">
        <property type="entry name" value="Ets DNA-binding protein pokkuri"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000418">
        <property type="entry name" value="Ets_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046328">
        <property type="entry name" value="ETS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003118">
        <property type="entry name" value="Pointed_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849:SF201">
        <property type="entry name" value="ETS DNA-BINDING PROTEIN POKKURI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00178">
        <property type="entry name" value="Ets"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02198">
        <property type="entry name" value="SAM_PNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00454">
        <property type="entry name" value="ETSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00413">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00251">
        <property type="entry name" value="SAM_PNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00345">
        <property type="entry name" value="ETS_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00346">
        <property type="entry name" value="ETS_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50061">
        <property type="entry name" value="ETS_DOMAIN_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51433">
        <property type="entry name" value="PNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNT" evidence="6">
        <location>
            <begin position="47"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="ETS" evidence="5">
        <location>
            <begin position="306"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="140"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="218"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="428"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="194"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="223"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="248"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="436"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0798762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="492" mass="54964" checksum="D095F8407893C6D8" modified="2020-02-26" version="1">MKLAPGPLPPIPTAATMDRLPLPLPFSPDLLWRYPLGFSNVTQQPPSSPLMDYKSQLPTSLATDPRVWSREDVISFLRWAEREYDLQPIDMDMFQMNGKAMCLLTRTDLSERAPGSGDVLHNVLQLLVREANIVQRCLPSSPVTPTSRHAYPLSPHSHPPTPNWNMLTQNGCDFHSTHAATLAAHLMAQSNSVTLSPAPSVDSQAGSPQHAEACQQPAYGHFSSGSNGSASGSNQSDSDEDSFPDSGKSAQNNTSPPNTPSAFTLVPPAHYMPPKSPKEAVSSPIFKTMAREFFPSESPEPNTNGRLLWDFLQQLLNDPSQRYTSYIAWKNRDTGVFKIVDPAGLAKLWGIQKNHLSMNYDKMSRALRYYYRVNILRKVQGERHCYQFLRNPTELKNIKNISLLRQQMSPNRPAPQPQPQVVHMTIKPEPAEVDQDTSRLQEFDEKPTDLSMDGPTDLSSNSSRHISIVCSPDTPSLRDPPQKNFYIKEEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ANS6</accession>
    <name>A0A5N4ANS6_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PPYR_06860</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0798980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ANS6"/>
    <dbReference type="FunCoup" id="A0A5N4ANS6">
        <property type="interactions" value="282"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4ANS6"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046949">
        <property type="term" value="P:fatty-acyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000007">
        <property type="entry name" value="4-coumarate--CoA ligase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF422">
        <property type="entry name" value="BCDNA.GH02901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="4">
        <location>
            <begin position="3"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="5">
        <location>
            <begin position="361"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0798980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="452" mass="50042" checksum="4A3D87103D693A5A" modified="2020-02-26" version="1">MIIIVITYLRNNHDEICKQLKDTEAKAIFTLTSLAPLANAAAKLANRTVPTITIKMASTDSTPDGTIDLRQLMDSKWDVEDLSPGGCNDIAVLPYSSGTTGLPKGVELTHRNIIANICQVTDTHVRLAQETTDEHQDVVPAILPLFHIFGLTGVLLTHLKNLCKVVTVPRFSPEQFLQLLTKHQPQILFVVPPIVGLMANQSELKKEYLQPVRTICSGAAPLGRKDEEKLKSKVGSHIEIIQGYGLTETSPAVFMASKRSKTRGVRGSVGEPLPNTSIKLITADSSQREINSPQDVGEIHVKGPQVMRGYYKKDKETNEAFADGWFKTGDVGYYDEHGMFFISERIKELIKVKGFQVAPTELEEILRNHPDIIEAAVIGVPHKQYGEVPKAYVVPKHNQQADVDGIQRYVAEKVAKYKHLKGGIEVVEAIPKTTSGKILRSELRKEYQKAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ANT4</accession>
    <name>A0A5N4ANT4_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_06885</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ANT4"/>
    <dbReference type="InParanoid" id="A0A5N4ANT4"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="37"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="124"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="371"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="515"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="622"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="818"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="141"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="166"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="182"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="196"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0799005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="899" mass="102419" checksum="7ABC5A6FD900E8BB" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4APB4</accession>
    <name>A0A5N4APB4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_07003</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4APB4"/>
    <dbReference type="InParanoid" id="A0A5N4APB4"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046949">
        <property type="term" value="P:fatty-acyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF422">
        <property type="entry name" value="BCDNA.GH02901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="58"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="4">
        <location>
            <begin position="480"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0799123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="578" mass="64424" checksum="BAB9551AB65DC538" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4APN4</accession>
    <name>A0A5N4APN4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">acid phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PPYR_07167</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.2" evidence="3"/>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4APN4"/>
    <dbReference type="FunCoup" id="A0A5N4APN4">
        <property type="interactions" value="603"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4APN4"/>
    <dbReference type="OrthoDB" id="5821688at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF211">
        <property type="entry name" value="PROSTATIC ACID PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00616">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00778">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024328541" description="acid phosphatase" evidence="9">
        <location>
            <begin position="25"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="376"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0799287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="415" mass="48502" checksum="D7DC0AE178C1BA25" modified="2020-02-26" version="1">MFVVPRSVILLLLVSEGLINHSSCEVEDTLLSVIVIYRHGDRAPIRPYQTDPYKDPSNWPMGWGQLTKIGKRQQYDLGRWLRERYKNFLPEEFSPRDIYVRSTDVDRTLMSAQCNLAGLFPPDANQTWNSNLAWQPVPVHTVPEQLDPVLSMKKPCERYRQLYQALFTTREFVDIQRENRELYEYLTQNTGNEIYNLETLEQLYNTLFIEELHNHTLPEWTKSVYPHKMARWADMSFALYTYNPKLALLRTGPLMDVIYKAFDNASLPKMHMFSAHDTTIADILNTLGIFDRHSPPYASTILFELRARGVNRLVNILYKNSTTPQRMILKDCQFDCPLDTFNEILDRIRLSDGEWESACEARFLGMVQFGTLQTGVFLGCMGLLFVLLCSFIISIVWSRRRRETVNYLRIPNQEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ARG6</accession>
    <name>A0A5N4ARG6_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_07688</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ARG6"/>
    <dbReference type="InParanoid" id="A0A5N4ARG6"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0799808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="151" mass="16720" checksum="DDEABE52D435A4E9" modified="2020-02-26" version="1">MQKTEVEEDTAQNKVTTQIDDFQYEHPKDDSLSPLPLPSITPAEDISTAAEQISNIDMSLTDIPVVIIPSQQDRTSLHSNTPDLPSPMDSVLTNEAVYSLLQNIHDSGEMRFTITKSYRPITINSHKEKVKHCADPPKCTSSINGTANQNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ARM8</accession>
    <name>A0A5N4ARM8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Lipase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_07885</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0800005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ARM8"/>
    <dbReference type="FunCoup" id="A0A5N4ARM8">
        <property type="interactions" value="49"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4ARM8"/>
    <dbReference type="OrthoDB" id="199913at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017171">
        <property type="term" value="F:serine hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00707">
        <property type="entry name" value="Pancreat_lipase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013818">
        <property type="entry name" value="Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033906">
        <property type="entry name" value="Lipase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000734">
        <property type="entry name" value="TAG_lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610:SF173">
        <property type="entry name" value="LIPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00151">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00821">
        <property type="entry name" value="TAGLIPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024433105" description="Lipase domain-containing protein" evidence="5">
        <location>
            <begin position="18"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="Lipase" evidence="6">
        <location>
            <begin position="47"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0800005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="347" mass="38399" checksum="F14402DE6101383B" modified="2020-02-26" version="1">MKGAILLALACLSVAAASQDRQMMLLDLPKDILGELMALLKGQKVVKSIQCTDPKPNDIELLLYTRHQKYDPVVLDVFAPSPIKSDKPVIFITHGWLQDIKDPQLQDLKNAYLERYDSDVVMVNWGKLAWDLYARTACKVPKIAQIIADYLCQVNYEKGMPLENVQLVGHSIGAHLVGFVGQFTQQMCNKRVGRITGLDPAGPLFNDAPTAERLDKSDADFVDIIHTNSKTFGYSDPIGHADFYASCGTFQSSCVIPDFKLDKLINMPMDAVFCSHRRSVDYMIESVLSSNFVATECKYCPIGCPPVIALVTRPGKAILGQQCSPDTRGKYYVPTNLKSPYATGGRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ARU5</accession>
    <name>A0A5N4ARU5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nuclear transcription factor Y subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_07927</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the NFYA/HAP2 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0800047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ARU5"/>
    <dbReference type="FunCoup" id="A0A5N4ARU5">
        <property type="interactions" value="153"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4ARU5"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016602">
        <property type="term" value="C:CCAAT-binding factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018362">
        <property type="entry name" value="CCAAT-binding_factor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001289">
        <property type="entry name" value="NFYA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12632">
        <property type="entry name" value="TRANSCRIPTION FACTOR NF-Y ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02045">
        <property type="entry name" value="CBFB_NFYA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00616">
        <property type="entry name" value="CCAATSUBUNTB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00521">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00686">
        <property type="entry name" value="NFYA_HAP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51152">
        <property type="entry name" value="NFYA_HAP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="258"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0800047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="326" mass="36150" checksum="628112099F22A2FC" modified="2020-02-26" version="1">MAHSRVENENRSFNFVRDLRKANHQMEQLTTADGQVVMQAVQNVSPQVQVMQMNATGQVIQGANGQQIMVHTVPQPGQLQNAQGIQQIQVVPQGQILLQQPAQQAQIVQTADGQTFIYQPVAIDNTNITQSQPTVLNINGNLVQLTSQTPASATPSQSPTTVVPQSTITTPNQIAMSNGNIVMMVPSTSGSSVNQFQRMPLPTNTEFLEEEPLYVNAKQYRRILKRRQARAKLEAEGKIPKERPKYLHESRHRHAMNRIRGEGGRFHSGSVKKRKEEEEQLQRSQQRSIGVTYNNPLDNAIIIEPVGVPVMTETLSSDPLSIGDAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AS02</accession>
    <name>A0A5N4AS02_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PPYR_07984</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0800104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AS02"/>
    <dbReference type="InParanoid" id="A0A5N4AS02"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF74">
        <property type="entry name" value="POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
        <property type="entry name" value="HTH_psq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="5">
        <location>
            <begin position="63"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="386"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="499"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="421"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="520"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0800104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="645" mass="73387" checksum="83E9B1D0A2597A76" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ATD5</accession>
    <name>A0A5N4ATD5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Succinate dehydrogenase assembly factor 2, mitochondrial</fullName>
            <shortName evidence="4">SDH assembly factor 2</shortName>
            <shortName evidence="4">SDHAF2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_06230</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit of the SDH catalytic dimer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Interacts with the flavoprotein subunit within the SDH catalytic dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SDHAF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000004">
        <property type="protein sequence ID" value="KAB0800490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ATD5"/>
    <dbReference type="FunCoup" id="A0A5N4ATD5">
        <property type="interactions" value="1366"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4ATD5"/>
    <dbReference type="OrthoDB" id="284292at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034553">
        <property type="term" value="P:mitochondrial respiratory chain complex II assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.250:FF:000002">
        <property type="entry name" value="Succinate dehydrogenase assembly factor 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.250">
        <property type="entry name" value="Flavinator of succinate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03057">
        <property type="entry name" value="SDHAF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005631">
        <property type="entry name" value="SDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036714">
        <property type="entry name" value="SDH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028882">
        <property type="entry name" value="SDHAF2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12469">
        <property type="entry name" value="PROTEIN EMI5 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12469:SF2">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03937">
        <property type="entry name" value="Sdh5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109910">
        <property type="entry name" value="YgfY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2 4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0800490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="142" mass="16720" checksum="4FCF8F9E522C520B" modified="2020-02-26" version="1">MFLRSSVTLPRLLCHRWASYKQSDVAIDPPEENLTLPLFHRKSNEDINTLKSRLVYQSRKRGMLENCLILSNFAAKHLPIMNKSQLDLYDKLINAPSNDWDLYYWATGIKETPKEFESEVMDMLKEYVKNPDKQSRIMQPDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AUS1</accession>
    <name>A0A5N4AUS1_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_05420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RGS7BP/RGS9BP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000003">
        <property type="protein sequence ID" value="KAB0801066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AUS1"/>
    <dbReference type="FunCoup" id="A0A5N4AUS1">
        <property type="interactions" value="120"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AUS1"/>
    <dbReference type="OrthoDB" id="9876293at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009968">
        <property type="term" value="P:negative regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026512">
        <property type="entry name" value="RGS7BP/RGS9BP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21029">
        <property type="entry name" value="R-SEVEN BINDING PROTEIN (R7BP) HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0734">Signal transduction inhibitor</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0801066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="124" mass="14746" checksum="FA9848F2F7A5AEA5" modified="2020-02-26" version="1">MSQLFLRELTKCHRLVQIIPMDMSGYYENRAGPSNIGNVISQILLCKQITPDFNQEELCSITKDSQEISKLLKELQEYMPKQENNLERNIALTEDLSQWTNKRRRNSLYKNMRFLCCIRRPNYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AVR4</accession>
    <name>A0A5N4AVR4_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_05674</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000003">
        <property type="protein sequence ID" value="KAB0801320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AVR4"/>
    <dbReference type="InParanoid" id="A0A5N4AVR4"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="133"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="40"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="54"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="87"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0801320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="199" mass="22534" checksum="1B1F35CEF4D47CD2" modified="2020-02-26" version="1">MDVAPRELKNIKIAPSVRESSPQYPNSPMMPPSPSSQNMKVTSSYREPSSMSIPYSPVSPMSASPSSQGTKVASSYREPTSVSIQYSPLSPMSSPASPTKEEHQNCGNVDDSDMDNILGYMDEEWLPNPLFIVSDAMRKFKELKTKYEQKLEEHKAIIAGLEWKLKIFKTRNLYAKNNLRNVNLIFNKWKTAVKSVYEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AXE8</accession>
    <name>A0A5N4AXE8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Insulin-degrading enzyme</fullName>
            <ecNumber evidence="9">3.4.24.56</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Insulin protease</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Insulysin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PPYR_04182</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">1611_PpyrPB1</strain>
            <tissue evidence="19">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>Degradation of insulin, glucagon and other polypeptides. No action on proteins.</text>
            <dbReference type="EC" id="3.4.24.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the peptidase M16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.56" evidence="9"/>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0801996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AXE8"/>
    <dbReference type="FunCoup" id="A0A5N4AXE8">
        <property type="interactions" value="1758"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AXE8"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000003">
        <property type="entry name" value="Insulin-degrading enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000030">
        <property type="entry name" value="Insulin-degrading enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000005">
        <property type="entry name" value="nardilysin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000004">
        <property type="entry name" value="Putative insulin-degrading enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050626">
        <property type="entry name" value="Peptidase_M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032632">
        <property type="entry name" value="Peptidase_M16_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054734">
        <property type="entry name" value="PqqF-like_C_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690:SF18">
        <property type="entry name" value="INSULIN-DEGRADING ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690">
        <property type="entry name" value="NARDILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16187">
        <property type="entry name" value="Peptidase_M16_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22456">
        <property type="entry name" value="PqqF-like_C_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="15">
        <location>
            <begin position="73"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="16">
        <location>
            <begin position="237"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 middle/third" evidence="17">
        <location>
            <begin position="421"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="domain" description="Coenzyme PQQ synthesis protein F-like C-terminal lobe" evidence="18">
        <location>
            <begin position="809"/>
            <end position="907"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00052248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00066874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00070422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00074992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00080349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF16187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF22456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAB0801996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1012" mass="116487" checksum="81A1B265E2A9B0F1" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AYJ5</accession>
    <name>A0A5N4AYJ5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Protein krueppel</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PPYR_04617</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AYJ5"/>
    <dbReference type="FunCoup" id="A0A5N4AYJ5">
        <property type="interactions" value="48"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AYJ5"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001290">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000557">
        <property type="entry name" value="zinc finger and SCAN domain-containing protein 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000478">
        <property type="entry name" value="Zinc finger protein 133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000688">
        <property type="entry name" value="zinc finger protein 197 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000690">
        <property type="entry name" value="Zinc finger protein 354C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000052">
        <property type="entry name" value="zinc finger protein 546 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050589">
        <property type="entry name" value="Ikaros_C2H2-ZF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012934">
        <property type="entry name" value="Znf_AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404:SF110">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07776">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00868">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51915">
        <property type="entry name" value="ZAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="6 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZAD" evidence="13">
        <location>
            <begin position="14"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="213"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="241"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="269"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="297"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="325"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="353"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="381"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="409"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAB0802431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="440" mass="50437" checksum="A3FA63EEFB2BB5BD" modified="2020-02-26" version="1">MSNTIIVTNDNLTKICRICLMEYEDMHSIFSEIQNVESLEEESTFLYEILMNISSIRVLANDGLPTTICTNCMELAHTSFKFQQQCNRSQEILEKYILHAKAGGEQSEAVKDEEVLNFLDANVSSSTRALVSDKCEMENVTSDAVFPYVECDKLGSAEETETKVLDAVKVAATEDNKRLRQRLALKRIQADTNVKEEPAAYVMKVNENGLKLYECSFCRKTYKHSNSLKVHLRSHTLERPYVCNQCGKGFKQYGALTYHFRSHTGEQPYVCKICGKRYRQSGTLTAHMRIHTGQRPFLCSVCGRGFRQAPDLGYHMRTHTKERPYMCNVCGKTMRMQCHLVQHLRIHTGERPFKCMECSKAFPSSTRLKRHAIIHTGLKPYICEVCKKAFNRLSSLRVHAKIHTDERPHVCSFCGKGFIQAHALKTHMNLHYDEEIPKVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AZH6</accession>
    <name>A0A5N4AZH6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein takeout</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_04746</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AZH6"/>
    <dbReference type="FunCoup" id="A0A5N4AZH6">
        <property type="interactions" value="28"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AZH6"/>
    <dbReference type="OrthoDB" id="8174700at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007623">
        <property type="term" value="P:circadian rhythm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.15.10.30:FF:000001">
        <property type="entry name" value="Takeout-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.30">
        <property type="entry name" value="Haemolymph juvenile hormone binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010562">
        <property type="entry name" value="Haemolymph_juvenile_hormone-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038606">
        <property type="entry name" value="To_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008:SF39">
        <property type="entry name" value="CIRCADIAN CLOCK-CONTROLLED PROTEIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008">
        <property type="entry name" value="PROTEIN TAKEOUT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06585">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00700">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0090">Biological rhythms</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024455682" description="Protein takeout" evidence="4">
        <location>
            <begin position="18"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00060902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0802560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="249" mass="28058" checksum="FA2CD2CA2FD72E19" modified="2020-02-26" version="1">MRSIALTAVIFVIATSANEESVTLPSFLRVCHQSDPKLNECIKEAVQKIKPLLADGLPEFDIPSLEPLHISEILIDHGAGALALKSTYTDIKVYGPSQFVLKSVRIDLKKDRVRLKLWLPHLRVVSQYTMNGRMLMMPISGKGESCGNYSNIDVTVTLQGQRITKHGDVYFNIKDFYVDFVLGHATIKLENLFNGDKHLGDTMNSFLNDNWQNVAKEIKPVLEDNVAKIFKKMANRIFSKYPLNVILPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AZX3</accession>
    <name>A0A5N4AZX3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_05052</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AZX3"/>
    <dbReference type="FunCoup" id="A0A5N4AZX3">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AZX3"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF269">
        <property type="entry name" value="NUCLEASE HARBI1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="8">
        <location>
            <begin position="110"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0802866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="323" mass="36641" checksum="95D7FF85EFA4701D" modified="2020-02-26" version="1">MSAVQVQFLINLIGPQIVKQDTIMRSAIPVYERVMVTLRFLATGDSYSSLQYLFRIPVCTIGRIVKEVTVAIYEMLKESYLKFPNTKNEWLCIANSFHSRWNFPHCVGAVDGKHVSIQNPHNSGSHYFNYKGTYSIILLAVADASYKLIYFDVGCNGRISDGGVFQNSSLHQGLEDGSIELPEPTPLPGRTDPVPYCFFGDDAFAMKPYMLKPYPYQNQPAPNRIFNYRLSRARRIIENVFGIMANKFRVLRKPIALAPETVSTTVQAICALHNYLLSDKTLKGNYIHQDLIDTENTETHTLIPGSWRDEIPNNSYFPLQKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B068</accession>
    <name>A0A5N4B068_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PPYR_05183</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B068"/>
    <dbReference type="InParanoid" id="A0A5N4B068"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15489">
        <property type="entry name" value="PHD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF74">
        <property type="entry name" value="POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
        <property type="entry name" value="HTH_psq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH psq-type" evidence="7">
        <location>
            <begin position="19"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="HTH CENPB-type" evidence="6">
        <location>
            <begin position="68"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="DDE-1" evidence="5">
        <location>
            <begin position="210"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0802997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="588" mass="65836" checksum="43C121469D72BC02" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B0T0</accession>
    <name>A0A5N4B0T0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF3730 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_00164</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B0T0"/>
    <dbReference type="FunCoup" id="A0A5N4B0T0">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4B0T0"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060147">
        <property type="term" value="P:regulation of post-transcriptional gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022542">
        <property type="entry name" value="FOCAD/RST1_DUF3730"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045163">
        <property type="entry name" value="Focadhesin/RST1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16212:SF4">
        <property type="entry name" value="FOCADHESIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16212">
        <property type="entry name" value="FOCADHESIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12530">
        <property type="entry name" value="DUF3730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3730" evidence="1">
        <location>
            <begin position="455"/>
            <end position="678"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0803194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1169" mass="134026" checksum="737387BDE7157C8F" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B1L5</accession>
    <name>A0A5N4B1L5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_00471</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B1L5"/>
    <dbReference type="FunCoup" id="A0A5N4B1L5">
        <property type="interactions" value="140"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4B1L5"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032589">
        <property type="term" value="C:neuron projection membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050808">
        <property type="term" value="P:synapse organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00099">
        <property type="entry name" value="IgV"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000129">
        <property type="entry name" value="CLUMA_CG018772, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001633">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037448">
        <property type="entry name" value="Zig-8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23279:SF4">
        <property type="entry name" value="DEFECTIVE PROBOSCIS EXTENSION RESPONSE 2, ISOFORM F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23279">
        <property type="entry name" value="DEFECTIVE PROBOSCIS EXTENSION RESPONSE DPR -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024340339" description="Ig-like domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="38"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="128"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0803501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="283" mass="31640" checksum="0EA0432839FDBEBE" modified="2020-02-26" version="1">MNFQRIFTLMLWTFILEPDGAKAHIEEFGYGANFSSYPYFEFNVPRNVTTTVGQTAFLHCRVEQLGDKAVSWIRKRDLHILTAGILTYTSDQRFQVIRPDKSDNWTLQIKFPQLRDSGIYECQVNTEPKMSLAYRLNVIEAKARVLGPGDLHVKAGSSVTLICVINQGPHDLGTVFWYLGANILQTPPTHPNDPDSTERLSIQNHWSDGLTSRLHISSARLSDSGNYSCVPTIAAPASVNVHVINGEHPAAMQHGNKNTAPLSPSLHCTLVYSISVFIIKHIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B1Q8</accession>
    <name>A0A5N4B1Q8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ELKS/Rab6-interacting/CAST family member 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PPYR_00463</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Presynapse</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A5N4B1Q8">
        <property type="interactions" value="14"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4B1Q8"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048788">
        <property type="term" value="C:cytoskeleton of presynaptic active zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098882">
        <property type="term" value="F:structural constituent of presynaptic active zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007274">
        <property type="term" value="P:neuromuscular synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048167">
        <property type="term" value="P:regulation of synaptic plasticity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019323">
        <property type="entry name" value="ELKS/CAST"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18861:SF0">
        <property type="entry name" value="BRUCHPILOT, ISOFORM J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18861">
        <property type="entry name" value="ELKS/RAB6-INTERACTING/CAST PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10174">
        <property type="entry name" value="Cast"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0770">Synapse</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="493"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="682"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1098"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1506"/>
            <end position="1533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1664"/>
            <end position="1715"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="165"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="229"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="1169"/>
            <end position="1295"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="1859"/>
            <end position="2020"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="96"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="682"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="704"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1105"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1664"/>
            <end position="1710"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0803493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2096" mass="246459" checksum="178DC8753D8B5DE0" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B2T7</accession>
    <name>A0A5N4B2T7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Flavin-containing monooxygenase</fullName>
            <ecNumber evidence="8">1.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PPYR_00680</name>
        <name evidence="9" type="ORF">PPYR_13324</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the FMO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="8"/>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B2T7"/>
    <dbReference type="FunCoup" id="A0A5N4B2T7">
        <property type="interactions" value="290"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4B2T7"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000138">
        <property type="entry name" value="Flavin-containing monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000960">
        <property type="entry name" value="Flavin_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000332">
        <property type="entry name" value="FMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00370">
        <property type="entry name" value="FMOXYGENASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0274">FAD</keyword>
    <keyword evidence="3 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0793704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0803710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="409" mass="46853" checksum="6AC55E1CA2EA27EF" modified="2020-02-26" version="1">MKIAIIGAGPSGLVSTKYSLDEGHEIDVYEQSGYIGGTWMYTDRIGVDEYGFPVHSSMYKGLMTNVPKEIMTFLDFPYPKQQTKSYISQQEVIKYFNQYADTFHLKEHIKYYKCVTCVEPLNNSNWSLIVSDVKSGSQEFYQFDSVFVCNGHYSSPTIPNIRGQSVYRGKQLHSHDYRKPEPYLNQRVLVVGGGSSGTDIAAKIAELADHVFLSCRHKEKIVSRKNLSTKPEITELSDYGATFQDGTKEDVDVILYCTGYAYTYPFLSEACGISVNDNWVYPLYKHIVNINHPTMFFIGIPFLVPVIPVCDIQVRFSLAQLRKKFLPPLKRMLEELEAYVNERELKNMPLRYYHKIGSEHLAEYFLELSEAAGIPSVPFVISKLYARARMDRNLEDCFQIVDGEHFIQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B445</accession>
    <name>A0A5N4B445_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DDE-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_01335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B445"/>
    <dbReference type="InParanoid" id="A0A5N4B445"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15517">
        <property type="entry name" value="PHD_TCF19_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF71">
        <property type="entry name" value="ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE-1" evidence="1">
        <location>
            <begin position="68"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0804365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="445" mass="49921" checksum="0104D15A8E97A6B1" modified="2020-02-26" version="1">MNFNPENVGKFFDNLSDVMERHNFEPHNIFNVDETGCTTVQKPNKVISLKGVKQVGAITSQERGTLVTMCFAINALGNSIPPMFVFPLVRYHDHFVRDGPDSCIGSANRSGWMQEEDFLIFIKHFAKFSKPSETNRVLLILDNHASHLYLPVIDFCRDNYITLLSFPPHTSHKLQPLDRGVYGPFKKFYNNSCDQWMKNNPGKRMTMYNIPSIAREAIQLAAVPKNITSGFRCCGIWPFNRNIFSDDEFAPSSVTDRPLNTASAVGEKEAILCPASTSTSSIEMPLNDANLNIINIPCEPSTPPKTSPIPPAAFYSPEEIRPLLKADFSKPVKTNKRAKGKTAILTDTPEKNLIEEKFNKKKVVAVTKKLHGSQTKKKNKQTIKRKVSENLSSSEDDSICIVCLGPYKESKEDWLQCRNCKEWAHCSCAGNNALFVCKNCDSDAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-06-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B557</accession>
    <name>A0A5N4B557_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_01717</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B557"/>
    <dbReference type="InParanoid" id="A0A5N4B557"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0804747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="65" mass="7705" checksum="904500E9AC3844F2" modified="2020-02-26" version="1">MDVAVFRTLKSGWKEQVSAWRLQNQHEPLRRRDFAPLLDAAIKDRKMMIDLIHLNNLKTSCKRIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B5T0</accession>
    <name>A0A5N4B5T0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UPAR/Ly6 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_01873</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B5T0"/>
    <dbReference type="InParanoid" id="A0A5N4B5T0"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024399843" description="UPAR/Ly6 domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0804903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="126" mass="13621" checksum="33F4973C8E2223C5" modified="2020-02-26" version="1">MRVQAASLTSTIIMNFKFVLASFGLMCVGVASGSSSTTCYSCFGVYNQSAEDVINCRYFVNITATDTCLTAPAYCIFYYGRDANSVAYSGRMCSPKDCDSLKATTSGGNLLHCSQCQSNYCNTDKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B6A4</accession>
    <name>A0A5N4B6A4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PiggyBac transposable element-derived protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_02054</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0805084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B6A4"/>
    <dbReference type="InParanoid" id="A0A5N4B6A4"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599:SF6">
        <property type="entry name" value="DUAL SPECIFICITY PHOSPHATASE 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="2">
        <location>
            <begin position="48"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="2">
        <location>
            <begin position="217"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0805084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="375" mass="43380" checksum="4CC31E827784BBAB" modified="2020-02-26" version="1">MEDDDRFDIESDAPSDHSVHNTDSEQSDEEIEDFVPEDESCWGLYITEEMIAQIVKYTNIYLAKIRPNYTRERDCLDTDTTEMCGFIGLLYMAGLQKSRYLNTKELWANSIFAPACFRLTMSRERFHLLGRAMRFDDINDRDERKKLDNLAPIREIFEKFVNKCEQNYQVGEYCTVDEMLENFRGRCKFRQYIANKPRLENVLPRQPVGPFQLDNSAFAVTMRIASPILNTGRNITLDNYFTSIPLAKELLGKRSTLVGTIKKNKREIPALFINLKRPVPSSMFGFQKDSVLLSYKPKPQKNVLMLSTFHAGDQIDPESGDMQKPEMVTFYNLTKGGVDVADQLKATYSVSRFCCRWPLRLFFTILDVGAINYNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B6K3</accession>
    <name>A0A5N4B6K3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Synaptosomal-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PPYR_02199</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Synapse</location>
            <location evidence="6">Synaptosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the SNAP-25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0805229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B6K3"/>
    <dbReference type="FunCoup" id="A0A5N4B6K3">
        <property type="interactions" value="119"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4B6K3"/>
    <dbReference type="OrthoDB" id="19261at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031629">
        <property type="term" value="P:synaptic vesicle fusion to presynaptic active zone membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016082">
        <property type="term" value="P:synaptic vesicle priming"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15885">
        <property type="entry name" value="SNARE_SNAP25C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15889">
        <property type="entry name" value="SNARE_SNAP25N_23N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000007">
        <property type="entry name" value="Synaptosomal-associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000018">
        <property type="entry name" value="Synaptosomal-associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000928">
        <property type="entry name" value="SNAP-25_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19305">
        <property type="entry name" value="SYNAPTOSOMAL ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19305:SF14">
        <property type="entry name" value="SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00835">
        <property type="entry name" value="SNAP-25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0770">Synapse</keyword>
    <keyword evidence="2" id="KW-0771">Synaptosome</keyword>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="10">
        <location>
            <begin position="25"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="10">
        <location>
            <begin position="147"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="108"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="63"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="108"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0805229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="212" mass="23594" checksum="5121D6018B8192F9" modified="2020-02-26" version="1">MPAPAPAAENGAPKSELQELQLKATQVTDESLDSTRRMLALCEESHEVGMKTLVMLDEQGEQLDRIEDGMDQINTDMREAEKNLTGMEKCCGLCVLPCQKGSSFKEDEGTWKGNDDGKVVNNQPQRMMDDRNGMGPQGGYIGRITNDAREEEMEENMGQVNTMIGNLRNMAIDMGSELENQNRQIDRINLKGESNETRIAVANQRANKLLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B7H5</accession>
    <name>A0A5N4B7H5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_02463</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0805493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B7H5"/>
    <dbReference type="InParanoid" id="A0A5N4B7H5"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000291">
        <property type="entry name" value="ALX homeobox protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050649">
        <property type="entry name" value="Paired_Homeobox_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24329">
        <property type="entry name" value="HOMEOBOX PROTEIN ARISTALESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24329:SF569">
        <property type="entry name" value="IP01065P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="22"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="24"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="108"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="116"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="181"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0805493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="197" mass="22562" checksum="4DC4A02A04197AE0" modified="2020-02-26" version="1">MAGPYLSPLPSDLLTEYMFGRRRQRRNRTTFSPQQLQELEALFQKTHYPDVFLREEVALRISLSEARVQVWFQNRRAKWRKQARLQLLQDAWRMRCLGLPTPPLILAGGVPPNEPHPQDKLHEKSSYPPMMTPGLPRPCPCSPNMDNIPDSSKLHTHSNTRTPSPTAPDDLSLPRKLSPPDSHTNPFIPRINSSNSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B7M0</accession>
    <name>A0A5N4B7M0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_02572</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0805602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B7M0"/>
    <dbReference type="InParanoid" id="A0A5N4B7M0"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF74">
        <property type="entry name" value="POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="4">
        <location>
            <begin position="74"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="DDE-1" evidence="3">
        <location>
            <begin position="226"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="406"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="410"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="427"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="478"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0805602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="653" mass="74811" checksum="FC758FC22DC3FD3E" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B7U1</accession>
    <name>A0A5N4B7U1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_02661</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0805691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A5N4B7U1">
        <property type="interactions" value="25"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4B7U1"/>
    <dbReference type="OrthoDB" id="1936617at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000281">
        <property type="term" value="P:mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032465">
        <property type="term" value="P:regulation of cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057946">
        <property type="entry name" value="TPR_ZFYVE26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028730">
        <property type="entry name" value="ZFYVE26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46591">
        <property type="entry name" value="ZINC FINGER FYVE DOMAIN-CONTAINING PROTEIN 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46591:SF1">
        <property type="entry name" value="ZINC FINGER FYVE DOMAIN-CONTAINING PROTEIN 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25569">
        <property type="entry name" value="TPR_ZFYVE26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="6">
        <location>
            <begin position="1198"/>
            <end position="1258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0805691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="2017" mass="232957" checksum="F5EA87B162DB5E57" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B817</accession>
    <name>A0A5N4B817_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_02664</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0805694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B817"/>
    <dbReference type="FunCoup" id="A0A5N4B817">
        <property type="interactions" value="86"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4B817"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08389">
        <property type="entry name" value="C2A_Synaptotagmin-14_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08408">
        <property type="entry name" value="C2B_Synaptotagmin-14_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000231">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000062">
        <property type="entry name" value="synaptotagmin-14 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043541">
        <property type="entry name" value="SYT14/14L/16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46129">
        <property type="entry name" value="SYNAPTOTAGMIN 14, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46129:SF2">
        <property type="entry name" value="SYNAPTOTAGMIN 14, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="171"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="326"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0805694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="467" mass="51879" checksum="2B067003B0968EE3" modified="2020-02-26" version="1">MKVGTEKHSVILIVKAYSFDVGGESSSESEMGGKTLPGPSGTVGPYFPPRSPHDLISLVEKGRVGISSNSSCSSTTSSVGEKHGLSSTKVTAEINSGQRSPNSLRETKIDNQNEEQTQENYQKTETVSKVTQHSIHSNSSRDCIVLMNTEADGTEVLSCIEAEAETQLVNKCGHLEIALLYDAPMRKMTVHVLQARDIPSRDRGQPTHTQVRLILLPSKKQKHKTKIRSGENPQYMESFLLHRVNPEDVNSMGIRLRLYGCERMRRERLIGEAIVSFANINLELENNFWLNLEPRANTALGGYTGELMSLARSDSTGSTHSMQHGGVPELLLGLSYNATTGRLSVEIVKGSHFRNLSLNRAPDTYVKLHLVSSTGQQLGYSKTTVRRGQPNPLFKETFVFQVALFQLADVTLMASVYNRRGVTKKKEMVGWFSLGLNSSGAEELAHWMDMKEFQQEQICRWHVLVQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1JWP9</accession>
    <name>A0A1Y1JWP9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protein phosphatase 1 regulatory subunit 12B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Myosin phosphatase-targeting subunit 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PPYR_10699</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">1611_PpyrPB1</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">1611_PpyrPB1</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Regulates myosin phosphatase activity. Augments Ca(2+) sensitivity of the contractile apparatus.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">PP1 comprises a catalytic subunit, PPP1CA, PPP1CB or PPP1CC, and one or several targeting or regulatory subunits. PPP1R12B mediates binding to myosin. Isoform 3 and isoform 4 bind PPP1R12A, but not isoform 1 of PPP1R12B itself. Binds IL16.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the NRARP family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01101477">
        <property type="protein sequence ID" value="JAV52641.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1JWP9"/>
    <dbReference type="FunCoup" id="A0A1Y1JWP9">
        <property type="interactions" value="886"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1JWP9"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004857">
        <property type="term" value="F:enzyme inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019208">
        <property type="term" value="F:phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21930">
        <property type="entry name" value="IPD_PPP1R12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000004">
        <property type="entry name" value="Phosphatase 1 regulatory subunit 12A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000007">
        <property type="entry name" value="Phosphatase 1 regulatory subunit 12A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017401">
        <property type="entry name" value="MYPT1/MYPT2/Mbs85"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051226">
        <property type="entry name" value="PP1_Regulatory_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031775">
        <property type="entry name" value="PRKG1_interact"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24179:SF21">
        <property type="entry name" value="MYOSIN BINDING SUBUNIT, ISOFORM O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24179">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15898">
        <property type="entry name" value="PRKG1_interact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038141">
        <property type="entry name" value="PP1_12ABC_vert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="13">
        <location>
            <begin position="76"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="13">
        <location>
            <begin position="109"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="13">
        <location>
            <begin position="203"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="13">
        <location>
            <begin position="236"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="cGMP-dependent protein kinase interacting" evidence="16">
        <location>
            <begin position="737"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="295"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="365"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="594"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="742"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="395"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="425"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="446"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="483"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="530"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="640"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="654"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="667"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="703"/>
            <end position="718"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00059024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00065548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00072757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00083252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF15898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="JAV52641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAB0796638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="833" mass="92962" checksum="361F44F71E27464B" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1JYW5</accession>
    <name>A0A1Y1JYW5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PPYR_07953</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="EMBL" id="GEZM01097048">
        <property type="protein sequence ID" value="JAV54333.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0800073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="FunCoup" id="A0A1Y1JYW5">
        <property type="interactions" value="1300"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1JYW5"/>
    <dbReference type="OrthoDB" id="6057829at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000008">
        <property type="entry name" value="Apoptosis-resistant E3 ubiquitin protein ligase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000013">
        <property type="entry name" value="Apoptosis-resistant E3 ubiquitin protein ligase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000975">
        <property type="entry name" value="Uncharacterized protein, isoform D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017868">
        <property type="entry name" value="Filamin/ABP280_repeat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058738">
        <property type="entry name" value="PH-like_AREL1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254:SF340">
        <property type="entry name" value="APOPTOSIS-RESISTANT E3 UBIQUITIN PROTEIN LIGASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25916">
        <property type="entry name" value="AREL1_PH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00630">
        <property type="entry name" value="Filamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50194">
        <property type="entry name" value="FILAMIN_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="6">
        <location>
            <begin position="219"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="9">
        <location>
            <begin position="623"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="7">
        <location>
            <position position="931"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="JAV54333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0800073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="964" mass="110180" checksum="452C6355F8F057B3" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1JZR0</accession>
    <name>A0A1Y1JZR0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">JmjC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PPYR_05328</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">1611_PpyrPB1</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">1611_PpyrPB1</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the UTX family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01098833">
        <property type="protein sequence ID" value="JAV53728.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000003">
        <property type="protein sequence ID" value="KAB0800974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1JZR0"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044666">
        <property type="term" value="C:MLL3/4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071558">
        <property type="term" value="F:histone H3K27me2/H3K27me3 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1370:FF:000001">
        <property type="entry name" value="lysine-specific demethylase 6A isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.20:FF:000002">
        <property type="entry name" value="lysine-specific demethylase 6A isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051630">
        <property type="entry name" value="Corepressor-Demethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046941">
        <property type="entry name" value="KDM6_GATAL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048562">
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</entry>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
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                <person name="Lewis S.M."/>
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        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
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                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAB0803698.1"/>
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        <source>
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        <source>
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    </evidence>
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</entry>
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    <reference evidence="16" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
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            <dbReference type="PubMed" id="28004739"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
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                <person name="Bessho-Uehara M."/>
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                <person name="Debat H.J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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        </source>
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            <text>a quinone + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + a quinol</text>
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        <property type="entry name" value="G3P_DH_FAD-dep"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11985">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11985:SF15">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16901">
        <property type="entry name" value="DAO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01001">
        <property type="entry name" value="FADG3PDH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00977">
        <property type="entry name" value="FAD_G3PDH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00978">
        <property type="entry name" value="FAD_G3PDH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-0274">FAD</keyword>
    <keyword evidence="6 14" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="EF-hand" evidence="15">
        <location>
            <begin position="619"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="15">
        <location>
            <begin position="656"/>
            <end position="691"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="JAV58164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAB0798711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="727" mass="81266" checksum="FA9339E80928F25B" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1KHU4</accession>
    <name>A0A1Y1KHU4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">E3 ubiquitin-protein ligase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_10935</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01085152">
        <property type="protein sequence ID" value="JAV60178.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01085151">
        <property type="protein sequence ID" value="JAV60180.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1KHU4"/>
    <dbReference type="InParanoid" id="A0A1Y1KHU4"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042415">
        <property type="term" value="P:norepinephrine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032436">
        <property type="term" value="P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042428">
        <property type="term" value="P:serotonin metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033263">
        <property type="entry name" value="RNF180"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46717">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF180"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46717:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF180"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="JAV60178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0796874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="113" mass="12569" checksum="EF11146A92508A69" modified="2017-08-30" version="1">MVSIKCKRCRNSILGNGECATLINAHGVKGSNEPQSCSSILEENLFYIDEEQLPDWIHSIVVDAHWSKGKLNCPHCKARIGSFDFVSGVKCACDEYILPPVHIINSKVDIIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1KLK7</accession>
    <name>A0A1Y1KLK7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Medium-chain acyl-CoA ligase ACSF2, mitochondrial</fullName>
            <ecNumber evidence="4">6.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PPYR_12287</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Acyl-CoA synthases catalyze the initial reaction in fatty acid metabolism, by forming a thioester with CoA. Has some preference toward medium-chain substrates. Plays a role in adipocyte differentiation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a medium-chain fatty acid + ATP + CoA = a medium-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:48340"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:59558"/>
            <dbReference type="ChEBI" id="CHEBI:90546"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>octanoate + ATP + CoA = octanoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:33631"/>
            <dbReference type="ChEBI" id="CHEBI:25646"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57386"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.2" evidence="4"/>
    <dbReference type="EMBL" id="GEZM01080213">
        <property type="protein sequence ID" value="JAV62293.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0795448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1KLK7"/>
    <dbReference type="InParanoid" id="A0A1Y1KLK7"/>
    <dbReference type="OrthoDB" id="10253115at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000008">
        <property type="entry name" value="2,3-dihydroxybenzoate-AMP ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF5">
        <property type="entry name" value="MEDIUM-CHAIN ACYL-COA LIGASE ACSF2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027165">
        <property type="entry name" value="CND3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025977">
        <property type="entry name" value="Cnd3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14418:SF5">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14418">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12719">
        <property type="entry name" value="Cnd3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nuclear condensin complex subunit 3 C-terminal" evidence="9">
        <location>
            <begin position="527"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="8">
        <location>
            <begin position="645"/>
            <end position="672"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="JAV64962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0792318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="856" mass="97371" checksum="6B042FF189633C07" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1KZK6</accession>
    <name>A0A1Y1KZK6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 11">AP-2 complex subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PPYR_05536</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">1611_PpyrPB1</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">1611_PpyrPB1</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Adaptins are components of the adapter complexes which link clathrin to receptors in coated vesicles.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Adaptor protein complex 2 (AP-2) is a heterotetramer composed of two large adaptins (alpha-type and beta-type subunits), a medium adaptin (mu-type subunit AP50) and a small adaptin (sigma-type subunit AP17).</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Adaptor protein complex 2 (AP-2) is a heterotetramer composed of two large adaptins (alpha-type and beta-type subunits), a medium adaptin (mu-type subunit) and a small adaptin (sigma-type subunit).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
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            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01075037">
        <property type="protein sequence ID" value="JAV64326.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
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    <dbReference type="EMBL" id="GEZM01075036">
        <property type="protein sequence ID" value="JAV64327.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
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        <property type="protein sequence ID" value="KAB0801182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1KZK6"/>
    <dbReference type="FunCoup" id="A0A1Y1KZK6">
        <property type="interactions" value="2105"/>
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    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030122">
        <property type="term" value="C:AP-2 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035615">
        <property type="term" value="F:clathrin adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000020">
        <property type="entry name" value="AP-2 complex subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1230:FF:000003">
        <property type="entry name" value="AP-2 complex subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000004">
        <property type="entry name" value="AP-2 complex subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Adaptor_Complx_Large_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017104">
        <property type="entry name" value="AP2_complex_asu"/>
    </dbReference>
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        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003164">
        <property type="entry name" value="Clathrin_a-adaptin_app_sub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008152">
        <property type="entry name" value="Clathrin_a/b/g-adaptin_app_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009028">
        <property type="entry name" value="Coatomer/calthrin_app_sub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22780">
        <property type="entry name" value="ADAPTIN, ALPHA/GAMMA/EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02296">
        <property type="entry name" value="Alpha_adaptin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02883">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037091">
        <property type="entry name" value="AP2_complex_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00809">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55711">
        <property type="entry name" value="Subdomain of clathrin and coatomer appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 11" id="KW-0168">Coated pit</keyword>
    <keyword evidence="5 11" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin adaptor alpha/beta/gamma-adaptin appendage Ig-like subdomain" evidence="14">
        <location>
            <begin position="703"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="623"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="623"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="639"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="659"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="10"/>
            <end position="11"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="56"/>
            <end position="60"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00062716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00068769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR037091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR037091-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="JAV64327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAB0801182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="936" mass="105214" checksum="CC666D536FBA5633" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1L0Q5</accession>
    <name>A0A1Y1L0Q5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycine N-methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PPYR_06831</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
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                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
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                <person name="Shigenobu S."/>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the eukaryotic/archaeal RNase P protein component 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01067004">
        <property type="protein sequence ID" value="JAV67598.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01067003">
        <property type="protein sequence ID" value="JAV67599.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1L474"/>
    <dbReference type="InParanoid" id="A0A1Y1L474"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007175">
        <property type="entry name" value="Rpr2/Snm1/Rpp21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14742:SF0">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14742">
        <property type="entry name" value="RIBONUCLEASE P SUBUNIT P21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04032">
        <property type="entry name" value="Rpr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="JAV67598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0804222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="117" mass="13551" checksum="4CC1E65A1CF44C10" modified="2017-08-30" version="1">MTQSGVKKCVGKDIFERMNYLLQLSSIAKPEASALYSHLLINVSQKAVQRMEPEVKRSICKRCHTLMIPGVSAQVRIRKKQLRWKCGKCLATKVFKTNPEYKLWIDHKEAVVETLRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1L9G8</accession>
    <name>A0A1Y1L9G8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex</fullName>
            <ecNumber evidence="4">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PPYR_11920</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="4"/>
    <dbReference type="EMBL" id="GEZM01061826">
        <property type="protein sequence ID" value="JAV70303.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0795081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1L9G8"/>
    <dbReference type="FunCoup" id="A0A1Y1L9G8">
        <property type="interactions" value="1585"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1L9G8"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045254">
        <property type="term" value="C:pyruvate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004742">
        <property type="term" value="F:dihydrolipoyllysine-residue acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000010">
        <property type="entry name" value="Acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000003">
        <property type="entry name" value="Acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045257">
        <property type="entry name" value="E2/Pdx1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151">
        <property type="entry name" value="DIHYDROLIPOAMIDE ACETYL/SUCCINYL-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151:SF90">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE ACETYLTRANSFERASE COMPONENT OF PYRUVATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2 4" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="6">
        <location>
            <begin position="68"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="158"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="168"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="JAV70303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0795081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="479" mass="51831" checksum="AE19BC7E996D4CB0" modified="2017-08-30" version="1">MLRTAVVRGNLLRQPIKKAIRSNITRTFTVEASKRKHFNSKVSLLQTEKHLIWQQRILRRYSSNLPAHTKVTLPALSPTMNMGNIVSWEKKEGDKLQEGDLLAEIETDKATMGFETPEEGYLAKILVPAGSKEVPIGKLVCIIVENAADVAAFKDYKDDSAPTGAAPSPAPPSPAPPTPMPPPPASPPPPTAIPLVQPSPAAAGDRVYASPMAKRLAEQRQIRLEGKVAVSDAAPAAKPKTVVVPAGAAYIDIPLTNMRSVIAKRLLESKTTVPHYYVTVDINIDKLLALRHKINKKNEKHGPKVSVNDFVVKATALASVAHPEVNSAWMGTAIRQYSDVDVSVAVSTPTGLITPIIFRANSKGINTISKEVKELAGKAREGKLQPAEFQGGTISVSNLGMYGVTHFTAIINPPQSAILAIGGNQTRLIPDDNSEKGFRKAHFISVTLSSDHRVVDGAKAAEWLGVFREYLEDPEMMIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LAD1</accession>
    <name>A0A1Y1LAD1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TNFR-Cys domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_09475</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01061259">
        <property type="protein sequence ID" value="JAV70599.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
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        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
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    <feature type="chain" id="PRO_5011907371" description="TNFR-Cys domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="101"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="JAV70599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0798482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="226" mass="25310" checksum="F4A98B0A3C632D09" modified="2017-08-30" version="1">MKCLVFLLVVTCFIFEVKSDLTLTGPKCGARFCQMQEYCSNYDNQCHPCSQICNQSTHNYDPTNCIKDCQDYLHDVRYVRKDEGSGGKDDLRGVVQKLQHMVTVTLTLTCFVLIALAFVIAFQIWKWKKNNNITFASLCNKLRSKNSNENKSPGNGIPPPGQANTKPDLRLDMPISTATHSEHSPATCTTSISRRPAEDSALDYAYDNRAMSSSPSPNTKPHESNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LAH8</accession>
    <name>A0A1Y1LAH8_PHOPY</name>
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        <recommendedName>
            <fullName evidence="9">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PPYR_07308</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the TFP11/STIP family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01061223">
        <property type="protein sequence ID" value="JAV70633.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1LAH8"/>
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    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1LAH8"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071008">
        <property type="term" value="C:U2-type post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
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        <property type="entry name" value="GCFC_dom"/>
    </dbReference>
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        <property type="entry name" value="STIP/TFIP11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024933">
        <property type="entry name" value="TFP11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045211">
        <property type="entry name" value="TFP11/STIP/Ntr1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23329:SF1">
        <property type="entry name" value="TUFTELIN-INTERACTING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23329">
        <property type="entry name" value="TUFTELIN-INTERACTING PROTEIN 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07842">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12457">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017706">
        <property type="entry name" value="TFIP11"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="G-patch" evidence="9">
        <location>
            <begin position="162"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="45"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="76"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="121"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR017706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="JAV70633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0799428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="830" mass="94543" checksum="DB6E25AB95C576D8" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LKM8</accession>
    <name>A0A1Y1LKM8_PHOPY</name>
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        <recommendedName>
            <fullName evidence="10">Fatty acyl-CoA reductase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PPYR_03002</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
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            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>a long-chain fatty acyl-CoA + 2 NADPH + 2 H(+) = a long-chain primary fatty alcohol + 2 NADP(+) + CoA</text>
            <dbReference type="Rhea" id="RHEA:52716"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:77396"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="EC" id="1.2.1.84"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the fatty acyl-CoA reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.84" evidence="10"/>
    <dbReference type="EMBL" id="GEZM01054708">
        <property type="protein sequence ID" value="JAV73471.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000011">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1LKM8"/>
    <dbReference type="InParanoid" id="A0A1Y1LKM8"/>
    <dbReference type="OrthoDB" id="6773957at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102965">
        <property type="term" value="F:alcohol-forming long-chain fatty acyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080019">
        <property type="term" value="F:alcohol-forming very long-chain fatty acyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035336">
        <property type="term" value="P:long-chain fatty-acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05236">
        <property type="entry name" value="FAR-N_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09071">
        <property type="entry name" value="FAR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000143">
        <property type="entry name" value="Fatty acyl-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026055">
        <property type="entry name" value="FAR"/>
    </dbReference>
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        <property type="entry name" value="FAR_C"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="7 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0521">NADP</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="365"/>
            <end position="386"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="475"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="Thioester reductase (TE)" evidence="12">
        <location>
            <begin position="24"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acyl-CoA reductase C-terminal" evidence="11">
        <location>
            <begin position="370"/>
            <end position="458"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00005928"/>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF07993"/>
        </source>
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            <dbReference type="EMBL" id="KAB0791202.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="500" mass="57322" checksum="6E93F328085C742F" modified="2017-08-30" version="1">MKWQPTMERSTSIQSYYADKTILITGATGFVGSYLVEKLLRSCPDVRRIYLLIRSKRRKDSESRLEEFLSDAIHNGLKQSNPSVLKKLAVITGDLELPRLGLSEVDEEKIVKEVNCIFHVGATVKFTEELRRAILINIGGTDSLIEIAKKIEDLKSFVHVSTAYSQCIRDIADEAFYVPEENYTDLITMANTISNEKLNEMTPTILGKWPNTYSFTKNIAEDLVRKKGTGLPMVIVRPSIVIAPYREPTTGWASSYDLTSLLVATINVGVVHTMCCDPKHVVDLVPVDFCVNQAIAAGWAVGREWSRMSKIPIYNFVSGPRNPITWGLQKDVLERSESALPSNRKIFHRYVLYGTNKKMLDLVELFYLPLMYIVNLKSFFLGKVHITLKTHRKIREFCKVVEFASCKEWYFKDDNTQNLWNLLEEEDRDVFCFDINSIDWQTFSDRITKGVRLYILKDDLSTVGRARTRSRLLKILQYFVVSAYVLLPLYIVHRLGTIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LKQ1</accession>
    <name>A0A1Y1LKQ1_PHOPY</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_04934</name>
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    <organism evidence="2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
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            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
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    <reference evidence="3" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="JAV74213.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAB0802748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="237" mass="25907" checksum="F6F120ABB4083109" modified="2017-08-30" version="1">MTEDNGNVSLLKPTSSSEDLSEYTDADESISAPTEFLAEFLSAVMLKDYETALKYCKLILQYEPNNGTAKEFYPLIIAKLQQNKYNGNHEDEHNSDGEEEEEDSSSSNSSSESDSSEGSSEEQEEQEVEQGADKRSKGSSDGTTGSYSSLEDDEAELDQLAALAAKYHVDNADFGNGNKIYGSVNLKPMFDSKRGDNIKSTIDHVPFGTSSDSESPTEPVTQQTIAMLRAKVVPTKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LS00</accession>
    <name>A0A1Y1LS00_PHOPY</name>
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        <recommendedName>
            <fullName evidence="4">CCR4-NOT transcription complex subunit 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PPYR_01276</name>
        <name evidence="12" type="ORF">PPYR_01277</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CNOT11 family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01049935">
        <property type="protein sequence ID" value="JAV75751.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KAB0804306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="10265389at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030014">
        <property type="term" value="C:CCR4-NOT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019312">
        <property type="entry name" value="CNOT11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15975">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15975:SF0">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10155">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="JAV75751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0804306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAB0804307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="455" mass="51348" checksum="012FD63301011468" modified="2017-08-30" version="1">MALSITQCDTLLNLLGENNVKTQTLEALANDLHKKFESTDYFKVGSCLIMLLQQDLLEEPEQRLVAVTLLHELYRGESIENTPFAKVFIHILHPPEQQSTVGTPKLEYPGQLPKFSAPEKNFIAQLISDVPKDAILKKTATQIINSDIVGPANIDLSAIQLALAEKQSELSHICRSGIPAVIAYPEKVTNSYANEPDKKEEFVQQILTSDNLYRVYKPEFVTLAPPLLNSKDEPVWFNVTSPKEHTVAYDITMCVPNMAGQEARQLMTKAYKAALSLQQQQQLLNELDNDSKLVYHIGLTPSKLPELVENNPLIAIEVLLKLMQSKQITEYFSVLVNMEMSLHSMEVVNRLTTTVDLPTEFVHLYISNCISTCETIKDRYMQNRLVRLVCVFLQSLIRNKIINVQELFIEVQAFCIEFSRIREAAALFRLLKQLESGELGLSMSPPPSMKGKLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LWW1</accession>
    <name>A0A1Y1LWW1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Alpha-1,3-glucosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PPYR_03931</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2 10">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the ALG6/ALG8 glucosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="EMBL" id="GEZM01044951">
        <property type="protein sequence ID" value="JAV78019.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0801745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1LWW1"/>
    <dbReference type="FunCoup" id="A0A1Y1LWW1">
        <property type="interactions" value="2017"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1LWW1"/>
    <dbReference type="OrthoDB" id="1689333at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042283">
        <property type="term" value="F:dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004856">
        <property type="entry name" value="Glyco_trans_ALG6/ALG8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12413">
        <property type="entry name" value="DOLICHYL GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12413:SF2">
        <property type="entry name" value="DOLICHYL PYROPHOSPHATE GLC1MAN9GLCNAC2 ALPHA-1,3-GLUCOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03155">
        <property type="entry name" value="Alg6_Alg8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033289775" description="Alpha-1,3-glucosyltransferase" evidence="11">
        <location>
            <begin position="23"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="122"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="151"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="182"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="304"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="339"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="398"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="440"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="470"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="JAV78019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAB0801745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="505" mass="58494" checksum="2A52D3FA1C16039A" modified="2017-08-30" version="1">MICVSFLLLSCVKLLLIPAYRSTDFEVHRNWLAITSNLPIDKWYYEDTSQWTLDYPPLFAWFEYFLSRIGYWFDPQMLVLNNHNYASFKTILFQRLSVILTDAIFAYGSYRCSQIFRKSWKSQAVLPLLLLTNVGLLLVDHIHFQYNGIMFGFLLLSCANLFQANYLSGAFWFLVLLNFKHIYLYIAPAYFIYLLRNYCITSRNLSIKNVITGFSVRNTIYLGSTVILVFAVTFVPFVGHINQVMSRLFPFKRGLCHAYWAPNFWAIYNVADKVLFMLGKKIGLAVSEEVAAMTGGLVQEFSHAVLPSITPLATMLITIVFMLPALMKLWFAGNNPVQFVRCIILCALTSFMFGWHVHEKAILMAIIPFSIISIMESGDAKVFLILSTVGQYSLLPLLFPQALLLIKLILYVLYCSYAFYSMSNLYPFYVCKFNLPLLNMLESMYIFGLIPLFLYDHFLHYSITLRTYPFLPLLLTSVYCSIGIVYSWLKYYIYFLTKCDAKHKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LXD8</accession>
    <name>A0A1Y1LXD8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">TATA box-binding protein-like 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">TBP-like factor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PPYR_08343</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TBP family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01044431">
        <property type="protein sequence ID" value="JAV78223.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1LXD8"/>
    <dbReference type="InParanoid" id="A0A1Y1LXD8"/>
    <dbReference type="OrthoDB" id="2127950at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04517">
        <property type="entry name" value="TLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000005">
        <property type="entry name" value="TATA box-binding protein-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000009">
        <property type="entry name" value="TatA box-binding protein-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000814">
        <property type="entry name" value="TBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015445">
        <property type="entry name" value="TBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10126">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00352">
        <property type="entry name" value="TBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00686">
        <property type="entry name" value="TIFACTORIID"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55945">
        <property type="entry name" value="TATA-box binding protein-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="JAV78223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
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                <person name="Bessho-Uehara M."/>
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                <person name="Bewick A.J."/>
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                <person name="Debat H.J."/>
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                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
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                <person name="Shigenobu S."/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PKD"/>
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    <keyword evidence="10" id="KW-0732">Signal</keyword>
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    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
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        <location>
            <begin position="19"/>
            <end position="962"/>
        </location>
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        <location>
            <begin position="857"/>
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        </location>
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        <location>
            <begin position="447"/>
            <end position="519"/>
        </location>
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        <location>
            <begin position="932"/>
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        </location>
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        <location>
            <begin position="932"/>
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        </location>
    </feature>
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        <location>
            <begin position="951"/>
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        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50093"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="JAV79885.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAB0793991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="962" mass="107316" checksum="E691E774B801F1BA" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="4">N-acetyltransferase 9-like protein</fullName>
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        <name evidence="7" type="ORF">PPYR_14446</name>
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        <name type="scientific">Photinus pyralis</name>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
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            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
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            <taxon>Elateroidea</taxon>
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            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
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    <reference evidence="7" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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        </source>
    </reference>
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        <text evidence="1">Belongs to the acetyltransferase family. GNAT subfamily.</text>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        </source>
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    </evidence>
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        </source>
    </evidence>
    <sequence length="197" mass="23056" checksum="FEAC4B758DB9641F" modified="2017-08-30" version="1">MLINQNTKIVSKNVVLVPYRKEHVEKYNNWMQSEELQRLTASEPLTLAEEYEMQQSWMRDENKCTFIILDRDTYDKTQNEIEAMVGDTNLFFANDLDHVVAEAEIMIAETQARGKHIGWRAMLLMLMYGVTSLHVRQYVVKITRDNQISINMFEKMGFVLTSTSEVFNEVTLNRIVDDSWITWLTATVGEYDVIEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
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        <recommendedName>
            <fullName evidence="5">Transport and Golgi organization protein 2</fullName>
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            <taxon>Coleoptera</taxon>
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    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
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            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
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    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01037814">
        <property type="protein sequence ID" value="JAV81917.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KAB0790306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="FunCoup" id="A0A1Y1MF26">
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="TANGO2"/>
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        <property type="match status" value="1"/>
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    </dbReference>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="265" mass="29973" checksum="E8BF6E4BC915EF35" modified="2017-08-30" version="1">MCILFLYTDPSPPSDGYRLIVATNRDEYFDRPTASAYHSIEENIIGGRDLQPGKEGGMWFGVSLNKTLRLGSLLNVTGADCNGKGRGYITSNYLKGDLPAEAYIDSLPDEYSAYNFVTAELSKTDTTVYHTSNCPSARTKFVGRQVLGFGNTPLDVPLQKVINGRGMFEEIVTNERDPERLTAKLLELLNCRERFLPDDELRRRSPAYEDLSSIFVNMERARYGTRAQTLILLNSDWELQFIEVAMEQPVDIKPTWQSCTFKIQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1MTU1</accession>
    <name>A0A1Y1MTU1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_11059</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
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        <lineage>
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            <taxon>Coleoptera</taxon>
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    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
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                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
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                <person name="Nelson D.R."/>
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                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">1611_PpyrPB1</strain>
            <tissue evidence="20">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">1611_PpyrPB1</strain>
            <tissue evidence="20">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Complex I is composed of 45 different subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFB5 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01013974">
        <property type="protein sequence ID" value="JAV92239.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1N332"/>
    <dbReference type="FunCoup" id="A0A1Y1N332">
        <property type="interactions" value="1188"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1N332"/>
    <dbReference type="OrthoDB" id="9995605at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019173">
        <property type="entry name" value="NADH_UbQ_OxRdtase_B5_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13178:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13178">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE SGDH SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09781">
        <property type="entry name" value="NDUF_B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="14 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="8 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="118"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00032550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="JAV92239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAB0802727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="171" mass="20625" checksum="7126C58789B5BB2C" modified="2017-08-30" version="1">MVILSTLRPILLQQIRTSNAVNRCMSDHRVFPYQPSRWQWNKFKDYAHFYILLGVIPLTLITVGANIFIGPATLSEIPEGYEPKHWEYHRSPISRFMAKYILTNPQQDYEKFLHHLYEENEKRILRKLEKEVKEKMKERNDYQAYYYQPVMAKYHRISRETADKLEEIRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1N465</accession>
    <name>A0A1Y1N465_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Palmitoyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PPYR_02834</name>
        <name evidence="11" type="ORF">PPYR_07963</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13 7">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="7"/>
    <dbReference type="EMBL" id="GEZM01013329">
        <property type="protein sequence ID" value="JAV92654.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0800083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1N465"/>
    <dbReference type="FunCoup" id="A0A1Y1N465">
        <property type="interactions" value="226"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1N465"/>
    <dbReference type="OrthoDB" id="331948at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12246">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="8">
        <location>
            <begin position="94"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="JAV92654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0791034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0800083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="266" mass="30517" checksum="5011DB6B746A51CC" modified="2017-08-30" version="1">MFVKDPCGIICVLVTYAAVLYADYVVIRWIVLQTMFNSLWGPFNAVAFNTIVFFLIMAHIRAVFSDPGVVPLPQSRVDFSDIHSAETGCEHVDWTVCTRCEMYRPPRAHHCRICKRCIKRMDHHCPWINNCVGERNQKYFMQFLVYVAILSGYAITLVVVSWIKECPDCDPTILIKQSRIMHCIILLLESALFGMFVAAILVDQLQAIFGDETGVEQVQHKGPYRAHKSKYALLSEVCGQQHPLMWLLPCNSTSRRFDTPLIDYHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1N5C1</accession>
    <name>A0A1Y1N5C1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PPYR_11079</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01015560">
        <property type="protein sequence ID" value="JAV91545.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01015559">
        <property type="protein sequence ID" value="JAV91546.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01015558">
        <property type="protein sequence ID" value="JAV91547.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0797018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1N5C1"/>
    <dbReference type="InParanoid" id="A0A1Y1N5C1"/>
    <dbReference type="OrthoDB" id="5330228at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070936">
        <property type="term" value="P:protein K48-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15067">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15067:SF4">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="10"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="188"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="263"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="JAV91546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0797018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="277" mass="31127" checksum="E7C02EC1968F94C5" modified="2017-08-30" version="1">MEISEDELLCSICNELFIKAITLPCLHKFCQHCIDQWRAQKSDCPICRAKITDYSRTTLLDDYIEKIVEGRDVEYRNRRKAEIEEREKPRPSPSSFREFSNIHSYVGNVDTSISPDESSDGSGLEGGSNYDSLFHSYREDIFLHLDDDSESDSMNHSRGDDNVSSFSSAQESIVDGDYEVYSVSSEDVLENGDASDSSHSTQDDTNDEHSSNSGGNEHEYVSGDATTDEDTENSSNSERSSVEGINNDDYYDFESDSSQNQEDSGDEIDFTSESDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1N6I0</accession>
    <name>A0A1Y1N6I0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Signal recognition particle 54 kDa protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PPYR_15151</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="19 20" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">1611_PpyrPB1</strain>
            <tissue evidence="19">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">1611_PpyrPB1</strain>
            <tissue evidence="19">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). As part of the SRP complex, associates with the SRP receptor (SR) component SRPRA to target secretory proteins to the endoplasmic reticulum membrane. Binds to the signal sequence of presecretory proteins when they emerge from the ribosomes. Displays basal GTPase activity, and stimulates reciprocal GTPase activation of the SR subunit SRPRA. Forms a guanosine 5'-triphosphate (GTP)-dependent complex with the SR subunit SRPRA. SR compaction and GTPase mediated rearrangement of SR drive SRP-mediated cotranslational protein translocation into the ER. Requires the presence of SRP9/SRP14 and/or SRP19 to stably interact with RNA. Plays a role in proliferation and differentiation of granulocytic cells, neutrophils migration capacity and exocrine pancreas development.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 16">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="16">The M domain binds the 7SL RNA in presence of SRP19 and binds the signal sequence of presecretory proteins.</text>
    </comment>
    <comment type="domain">
        <text evidence="16">The NG domain, also named G domain, is a special guanosine triphosphatase (GTPase) domain, which binds GTP and forms a guanosine 5'-triphosphate (GTP)-dependent complex with a homologous NG domain in the SRP receptor subunit SRPRA. The two NG domains undergo cooperative rearrangements upon their assembly, which culminate in the reciprocal activation of the GTPase activity of one another. SRP receptor compaction upon binding with cargo-loaded SRP and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the GTP-binding SRP family. SRP54 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01013898">
        <property type="protein sequence ID" value="JAV92265.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01001249">
        <property type="protein sequence ID" value="KAB0790462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1N6I0"/>
    <dbReference type="FunCoup" id="A0A1Y1N6I0">
        <property type="interactions" value="1424"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1N6I0"/>
    <dbReference type="OrthoDB" id="10250817at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030942">
        <property type="term" value="F:endoplasmic reticulum signal peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006616">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17875">
        <property type="entry name" value="SRP54_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.30:FF:000002">
        <property type="entry name" value="Signal recognition particle 54 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.140:FF:000003">
        <property type="entry name" value="Signal recognition particle 54 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000022">
        <property type="entry name" value="Signal recognition particle 54 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="entry name" value="Signal recognition particle SRP54, nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.30">
        <property type="entry name" value="Signal recognition particle, SRP54 subunit, M-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00306">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036891">
        <property type="entry name" value="Signal_recog_part_SRP54_M_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004125">
        <property type="entry name" value="Signal_recog_particle_SRP54_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022941">
        <property type="entry name" value="SRP54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006325">
        <property type="entry name" value="SRP54_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01425">
        <property type="entry name" value="SRP54_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 54K PROTEIN SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564:SF5">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE SUBUNIT SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02978">
        <property type="entry name" value="SRP_SPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47446">
        <property type="entry name" value="Signal peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 16" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 16" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13 16" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="9 16" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="11 16" id="KW-0733">Signal recognition particle</keyword>
    <feature type="domain" description="SRP54-type proteins GTP-binding" evidence="17">
        <location>
            <begin position="269"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU364034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="JAV92265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAB0790462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="508" mass="55778" checksum="BBF5BFFE439F1F77" modified="2017-08-30" version="1">MVLADLGRKITTALQSLSKATIINEEVLNGMLKEICAALLEADVNIKLVKTLRENVRAVIDFDEMAGGLNKRRMIQSAVFKELVKLVDPGVKPYQPHKGKPNIIMFVGLQGSGKTTTCTKLAYHYQKKNWKSCLVCADTFRAGAYDQVKQNCTKARIPFYGSYTEVDPVIIAQDGVDMFKKEGFEIIIVDTSGRHKQEESLFEEMLAVSNAVKPDNIIFVMDATIGQACEAQAKAFKDKVDVGSVIITKLDGHAKGGGALSAVAATNSPVIYIGTGEHIDDLEPFKTKPFISKLLGMGDIEGLIDKVNELKLEDNEELLEKIKHGQFTLRDMYEQFQNIMKMGPFSQIMGMIPGFSQDFMSKGSEQESMARLKRLMTIMDSMNEGELDNRDGAKIFSKQQSRITRVAQGSGVTEKEVKELITQYTKFAAVVKKMGGIKGLFKGGDMAKNVNPAQLAKLNQQMAKMMDPRILHQMGGMAGLQNMMRQLQAGAAGGMGGLGNLMNSFGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N3ZYK0</accession>
    <name>A0A5N3ZYK0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_15530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01001821">
        <property type="protein sequence ID" value="KAB0790146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N3ZYK0"/>
    <dbReference type="InParanoid" id="A0A5N3ZYK0"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48411">
        <property type="entry name" value="OS01G0948300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48411:SF1">
        <property type="entry name" value="OS01G0948300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13716">
        <property type="entry name" value="CRAL_TRIO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="9"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0790146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="164" mass="19259" checksum="431B86CC2B998B33" modified="2020-02-26" version="1" fragment="single">YERLLRRAKAEDLSEVSGIGCLYQSGVDRLGRPVVVFVGKWFPFNKLNLDKALLYLILLLDPIVKGDYVITYFHTLTSNSNYPSFSWLKEVYNVLPYKYKKNLKAFYIIHPTFWTKMMTWWFTTFMAPAIKQKVHSLPGVEYLYAVMSPEQLEIPAYITEYDMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N3ZZ29</accession>
    <name>A0A5N3ZZ29_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_15333</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01001486">
        <property type="protein sequence ID" value="KAB0790327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N3ZZ29"/>
    <dbReference type="InParanoid" id="A0A5N3ZZ29"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF12">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0790327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="217" mass="24354" checksum="8BB47509E6294574" modified="2020-02-26" version="1">MIRQALVAPYHPSSNGQAERMVQNVKNAIRKMTEGTAEGNLQLALSRYLLAQHITPHCTTGRSPAEILMGRKLNTVYDRMQPDFRKEMMAKQKDEYPIPGKDRVFQDGDAVFARSFTPGSKWLPAQVVSTTGPVSYRVQTPDGQTLRRHSDQIRARVEEPTESLGTLGDPEIPPTTPEVANCSEPQQQDNGDSQIVEIKKPPERSRRAPKYLEDFVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N3ZZC2</accession>
    <name>A0A5N3ZZC2_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_15218</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01001355">
        <property type="protein sequence ID" value="KAB0790412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N3ZZC2"/>
    <dbReference type="InParanoid" id="A0A5N3ZZC2"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF1">
        <property type="entry name" value="GAG-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0790412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="126" mass="14561" checksum="A7CAA03BEFCACDE9" modified="2020-02-26" version="1" fragment="single">STTVLQWLKSTYITDIFVANRIEQIRENLPSSVWRHVSGTENPADCLSRGLSPLQLMEHRLWLSGPAWLQINESLWPVTSIDLGEEGLEGDQHIHTSLVNVREKEEHPLYELVLRRSSWSFILRTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A166</accession>
    <name>A0A5N4A166_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4773 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_02831</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A166"/>
    <dbReference type="InParanoid" id="A0A5N4A166"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031941">
        <property type="entry name" value="DUF4773"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36299">
        <property type="entry name" value="AGAP008005-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36299:SF1">
        <property type="entry name" value="DUF4773 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15998">
        <property type="entry name" value="DUF4773"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4773" evidence="2">
        <location>
            <begin position="119"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0791031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="276" mass="31191" checksum="E5321753E6BFE2E5" modified="2020-02-26" version="1">MCETLLTTHVISSRKADIDFDIRKFHEMYCSAWKPKLETAKISAFLILCALLLVCVSASTLESDMSQMLIYYEPRSRLPLRITSIQNSLSNSSLGFHQSNTKVDAEVVLRRFGFRSNGCTCQEFYCGCCAGFNFQQFNFNREGCMRFTYNPYEFSISVDMSMNDESIFSTTISARNPPPFCIPIPLPFLPTVDFCAKLLDIYTPGQNLHMCLDFETRIQRATVLILHFNCMQMGVDGVSLLRPGESAGGLPVTTEAQVDVDKFDEITENKYKSPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-06-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A1L0</accession>
    <name>A0A5N4A1L0_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_02979</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A1L0"/>
    <dbReference type="InParanoid" id="A0A5N4A1L0"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="67"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0791179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="207" mass="23416" checksum="3B4F9EC4D1437D87" modified="2020-02-26" version="1">MELRSGNIISPSSVPIVRTNLMESFRSVEYDNTDVTIPENDVTHDNEAMLTTMPVITETIQQSTSPTADINVQLEQMQQAMQDLETRFELALRIRERTIDNLQNRLRQFKSCETDLVHEKDAEIENSVGTTRQDVDNSVSFPKLIPQMTTNTSLASSALTELANTAFSARQQAPNSSKEETQISYIESISKRPRIQPIWTSNPALWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A2D8</accession>
    <name>A0A5N4A2D8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UDP-glucuronosyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PPYR_03259</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:132367"/>
            <dbReference type="ChEBI" id="CHEBI:132368"/>
            <dbReference type="EC" id="2.4.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Membrane</location>
            <topology evidence="5">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.17" evidence="5"/>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A2D8"/>
    <dbReference type="InParanoid" id="A0A5N4A2D8"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015020">
        <property type="term" value="F:glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000050">
        <property type="entry name" value="UDP-glucuronosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035595">
        <property type="entry name" value="UDP_glycos_trans_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF159">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00375">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024485478" description="UDP-glucuronosyltransferase" evidence="5">
        <location>
            <begin position="18"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="466"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0791459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="500" mass="56896" checksum="8CDA03B503EE3634" modified="2020-02-26" version="1">MFALLVLCTLSCSGVSASKILGISLTPSYSHQIVFQPLWRELSLRGHQVTTITPNPINDLKLINLTEIDLGFVRLSNLEVKGLMRQSTFLHEIYLMYTFMATMMDKQLEYPPVKQLLNDRSARFDLVIVEYLWTAPLAFAKRFDCPYIGVLSTDGVNSNHRKIGNPAHSSLYPDLFLSYGDKLSIFERVVSFVYELFYEVYFEGVLHELEQKVVHKHFGDHYPSVAEMARNVSMLFVNSDPIFHHNRPLVPGVVQIGGSHYPKEPVGLPPELKATLDNASNGFIYFSLGSNVQSEMLPPELLDVFLSVFAELPYTVLWKFGSDILPNKTDNIIISKWFPQPEVLKHPNIKLFITQGGVQSLGEAVSAHVPIVGVPFLVDQPYNVKNLERKGCGLMLDYRNLDREQFKLAILEVINNPRYRNTMKRLSELALDQPMTGVEKAVWWVEYVLRHKGAKHLKSPFLDLPWYQYLLLDVIGVVVLTLCAIVLSLRYTIRIIGKIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A2Q1</accession>
    <name>A0A5N4A2Q1_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_03414</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VPRBP/DCAF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A5N4A2Q1">
        <property type="interactions" value="1944"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A2Q1"/>
    <dbReference type="OrthoDB" id="27563at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033270">
        <property type="entry name" value="VPRBP/DCAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13129:SF4">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13129">
        <property type="entry name" value="VPRBP PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1323"/>
            <end position="1414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1329"/>
            <end position="1354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1372"/>
            <end position="1381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0791614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1414" mass="159283" checksum="979FBF42DB91D900" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A3B6</accession>
    <name>A0A5N4A3B6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase M13 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_03620</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A3B6"/>
    <dbReference type="InParanoid" id="A0A5N4A3B6"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF167">
        <property type="entry name" value="FI17812P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="89"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="4">
        <location>
            <begin position="143"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0791820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="337" mass="38471" checksum="2B0DAEF0139CC3F4" modified="2020-02-26" version="1">MEKPLATRTRHETYAELVQLAFPNPNDMRKIDDGWCEKPIPEKNGVKTVTSTSVTTFQDSDPNPTIHSSTSELMSELWSKSRKITSDRLNVLHISTIILLILLFIEAIIIIVLSKEDPQACLTPGCIETSFQISHKLDTSVDPCTDFYEFACGNYKNEIILEEHQQTRNIFTDVSEAMYTRIELLFNTSFSGPKHHHILTKLYNLCLDNNAKDVIMIPSIITQLSSWPILEGIKWNPNNFHWTEVMVKSKKLGLPYNSFIQIDVQPNLYNTSKNVLTIDCCTAPLIQAEKYVNETLRVLNLSAISTEDLIQFVTFRNNIMKASVNNVKMRPFSHFIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A3L5</accession>
    <name>A0A5N4A3L5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Bicaudal D-related protein homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_03659</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A3L5"/>
    <dbReference type="FunCoup" id="A0A5N4A3L5">
        <property type="interactions" value="31"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A3L5"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051149">
        <property type="entry name" value="Spindly/BICDR_Dynein_Adapter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32123:SF13">
        <property type="entry name" value="BICAUDAL D-RELATED PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32123">
        <property type="entry name" value="BICD FAMILY-LIKE CARGO ADAPTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="62"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="399"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0791859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="490" mass="56553" checksum="C1BFAEE0D3B7C9D3" modified="2020-02-26" version="1">MQTLEDYILEMENRSAIRQNSNTDDLWTQLQQKENDLVLAAELGKALLEKNEELTKQHDAAVEDFCKKLEAVEQDRHLLKRKLASLESEYEARILELQNDISELTSKLSARESTIKQWERDKGNLVSELNAQNQRLTTQLKEAVTLETQLQLEIGHLRQECAMGKSSLHEHINSADSLRDELELVSAKKGELERRLIMAANERDNLATALEEASDRILLLERHAREQDIRYQQSLKEYSLPQERLSIEERISEMDVCEPTLSQECMSVYRQLRALCQQLKSHNDDDSGLHSDCSTTSFDDSQQFSAGLLNEVAQELVGLVLDTDVVRLLDRLEQARRDIQERDMELSRRGETVMDLTSKVSVCEVELRTALEERDRARHDASNSSMAQDEAVVKAREVRDQAVARRNKAEVELAKTRVELMQANSQLLEAIQQKVELSQQLEQWQMDMQELLDEQLKNKLTSHEVKMRNDAQLSPPAAPPRRRLLRFFQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A5I3</accession>
    <name>A0A5N4A5I3_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PPYR_09151</name>
        <name evidence="12" type="ORF">PPYR_14555</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A5I3"/>
    <dbReference type="InParanoid" id="A0A5N4A5I3"/>
    <dbReference type="OrthoDB" id="6770093at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18579">
        <property type="entry name" value="ABC_6TM_ABCC_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000026">
        <property type="entry name" value="Multidrug resistance-associated protein lethal(2)03659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000014">
        <property type="entry name" value="Multidrug resistance-associated protein member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000163">
        <property type="entry name" value="Multidrug resistance-associated protein member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000482">
        <property type="entry name" value="Multidrug resistance-associated protein member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044746">
        <property type="entry name" value="ABCC_6TM_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF456">
        <property type="entry name" value="MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN LETHAL(2)03659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="318"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="352"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="682"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="725"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="764"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="805"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="907"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="99"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="407"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="686"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="996"/>
            <end position="1229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAB0792596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAB0798158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1260" mass="141705" checksum="76EA9373D225C3F7" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A6S9</accession>
    <name>A0A5N4A6S9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_12641</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A6S9"/>
    <dbReference type="InParanoid" id="A0A5N4A6S9"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035023">
        <property type="term" value="P:regulation of Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04402">
        <property type="entry name" value="RhoGAP_ARHGAP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047886">
        <property type="entry name" value="ARHGAP20-like_RhoGAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047887">
        <property type="entry name" value="ARHGAP20_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23179:SF3">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23179">
        <property type="entry name" value="T-CELL ACTIVATION RHO GTPASE ACTIVATING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22286">
        <property type="entry name" value="RHG20_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="4">
        <location>
            <begin position="357"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="591"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0793021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="703" mass="78535" checksum="229A0755A7ACFFEA" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A6Z7</accession>
    <name>A0A5N4A6Z7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NFU1 iron-sulfur cluster scaffold homolog, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PPYR_12717</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Molecular scaffold for [Fe-S] cluster assembly of mitochondrial iron-sulfur proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NifU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A6Z7"/>
    <dbReference type="FunCoup" id="A0A5N4A6Z7">
        <property type="interactions" value="998"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A6Z7"/>
    <dbReference type="OrthoDB" id="565552at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.130:FF:000001">
        <property type="entry name" value="NFU1 iron-sulfur cluster scaffold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.70:FF:000002">
        <property type="entry name" value="NFU1 iron-sulfur cluster scaffold homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="entry name" value="Fe-S cluster assembly (FSCA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.70">
        <property type="entry name" value="Scaffold protein Nfu/NifU, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014824">
        <property type="entry name" value="Nfu/NifU_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036498">
        <property type="entry name" value="Nfu/NifU_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035433">
        <property type="entry name" value="NFU1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001075">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11178">
        <property type="entry name" value="IRON-SULFUR CLUSTER SCAFFOLD PROTEIN NFU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11178:SF1">
        <property type="entry name" value="NFU1 IRON-SULFUR CLUSTER SCAFFOLD HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08712">
        <property type="entry name" value="Nfu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01106">
        <property type="entry name" value="NifU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036773">
        <property type="entry name" value="HIRIP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00932">
        <property type="entry name" value="Nfu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="Fe-S cluster assembly (FSCA) domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110836">
        <property type="entry name" value="Hypothetical protein SAV1430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Scaffold protein Nfu/NifU N-terminal" evidence="10">
        <location>
            <begin position="42"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0793097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="249" mass="27897" checksum="55FB696C37A17AF9" modified="2020-02-26" version="1">MWRNSLKLLVNSIKTQEKYVPPLALQGFSKHIHRSSPLAMFVQTQETPNPNSLKFLPGVKVLESGQTMDFPTGQSAFCSPLGKLLFRIEGVKGVFLGPDFITVTKSDDDVEWKLIKPEIFATIMDFFASGLPVLQEGVPNSDTQVNEDDSEIVQMIKELLDTRIRPTVQEDGGDLLFMGYDDGVVKLKMQGSCSSCPSSIVTLKNGVQNMLQFYIPEVVAVEQVDEPSDKVSEKEFKQFEMKLKQLEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-06-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A791</accession>
    <name>A0A5N4A791_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_12795</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A791"/>
    <dbReference type="InParanoid" id="A0A5N4A791"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0793175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="133" mass="15871" checksum="87362237116E780B" modified="2020-02-26" version="1">MGQIFMAYSCLQQCNPKTFSKKEIDHLSDRMKNVLESAEARNIFNKYLHEVRRGDLLKVLVLWCKADLHLRESQVMSDSFEDLIDEIDDFNTMPFLSINENNFKLLYVKQECCRILSKILNNFVKYLEKYHMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A7B2</accession>
    <name>A0A5N4A7B2_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_12837</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A7B2"/>
    <dbReference type="InParanoid" id="A0A5N4A7B2"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.10">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="309"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0793217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="331" mass="39006" checksum="978C58673B3A1DB0" modified="2020-02-26" version="1">MQRSALDIVLCYTPSYWQPHPYQDTIYIKVGINKNTEEYRTVDKIIHNTFSNVAIDRIQRIQHPFAYGRFLIRKQQLTLINKREQTANRVILSITDHSKLDSILHYNCDSRLGGFSQEHRLHSHGFILIIKTLSQLPCERDSDRYPEYLIAYRQIQWPSSNRPVVSSIQPTSSTSLIKDNSRSSQSTISPYKHNSPKTVQRIYDSYESVPWDCGYSSRDNLAPTSSYEHSSTKNVQRIYDSYEYSSWRYSSRDNFAPTSSSTLSSIKNVQSNDKNYEYDYQYDNLSRYDSRYNPAEWPGPSSDNHGRRWRWWLWIGAALIVVYIYRRRLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A7Q5</accession>
    <name>A0A5N4A7Q5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Dynein regulatory complex protein 1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_12974</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DRC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A7Q5"/>
    <dbReference type="FunCoup" id="A0A5N4A7Q5">
        <property type="interactions" value="28"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A7Q5"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005858">
        <property type="term" value="C:axonemal dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070286">
        <property type="term" value="P:axonemal dynein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060285">
        <property type="term" value="P:cilium-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003352">
        <property type="term" value="P:regulation of cilium movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039505">
        <property type="entry name" value="DRC1/2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039750">
        <property type="entry name" value="DRC1/DRC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029440">
        <property type="entry name" value="DRC1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21625:SF1">
        <property type="entry name" value="DYNEIN REGULATORY COMPLEX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21625">
        <property type="entry name" value="NYD-SP28 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14772">
        <property type="entry name" value="NYD-SP28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14775">
        <property type="entry name" value="NYD-SP28_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynein regulatory complex protein 1/2 N-terminal" evidence="5">
        <location>
            <begin position="91"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein regulatory complex protein 1 C-terminal" evidence="6">
        <location>
            <begin position="702"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="111"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="325"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0793354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="748" mass="87341" checksum="60272A390768E859" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A8W8</accession>
    <name>A0A5N4A8W8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PPYR_13391</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A8W8"/>
    <dbReference type="InParanoid" id="A0A5N4A8W8"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048619">
        <property type="term" value="P:embryonic hindgut morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009880">
        <property type="term" value="P:embryonic pattern specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003002">
        <property type="term" value="P:regionalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000318">
        <property type="entry name" value="Odd-skipped-related transciption factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000148">
        <property type="entry name" value="zinc finger protein Gfi-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050717">
        <property type="entry name" value="C2H2-ZF_Transcription_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14196">
        <property type="entry name" value="ODD-SKIPPED - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14196:SF0">
        <property type="entry name" value="PROTEIN BOWEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="60"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="285"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="121"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="285"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="305"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAB0793771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="331" mass="36827" checksum="F0750C61F8110CA2" modified="2020-02-26" version="1">MEESPHKCPVCSRSFNQRSNLKTHLLTHTDHKPYECNSCGKVFRRNCDLRRHALTHAVGDVPADDLGDGFAASNDLEPLSPRPRSPSHDGREESIRTCSPTPERTQCHEPCSSSSPYTMRPHPDSLDKRTEHDIDDPELDDEPEIDPGQEENPEPEPPHPQLQIRRDLHHPTLKSSTITSASMEMGFLSPFRKRVLDADRPSTITNSGRQTPPMALRIAPMHLPPPPPHLISQSVPIPPTPPVLKPPDHPPPPIHVLSLPPTSAHMSSNIIRNIPHKYNCEPCPSTSGATGNNFASDLSMKKELPPPPRPPHNPPPPPRKTGFTIEDIMRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A901</accession>
    <name>A0A5N4A901_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PPYR_13348</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A901"/>
    <dbReference type="InParanoid" id="A0A5N4A901"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990837">
        <property type="term" value="F:sequence-specific double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000303">
        <property type="entry name" value="Zinc finger protein 41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF48">
        <property type="entry name" value="ZINC FINGER PROTEIN 771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="342"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="370"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="398"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="426"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="290"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="309"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAB0793728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="525" mass="57953" checksum="72C4E945B63BF4AD" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ABA8</accession>
    <name>A0A5N4ABA8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_11441</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0794602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ABA8"/>
    <dbReference type="FunCoup" id="A0A5N4ABA8">
        <property type="interactions" value="52"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4ABA8"/>
    <dbReference type="OrthoDB" id="6478865at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013270">
        <property type="entry name" value="CD47_Vset"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21261">
        <property type="entry name" value="BEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21261:SF2">
        <property type="entry name" value="GH04238P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08204">
        <property type="entry name" value="V-set_CD47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="43"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0794602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="266" mass="29990" checksum="6E666690FDEFF64D" modified="2020-02-26" version="1">MNLYKSAYWTKWAISLYVIIFLLDVTVGVRINKLQVPEVTHIGSPVILDCDYSWEETKDEGIVVKWYFNEEKIPVYQWIATKKPQVLGILKGRLNLEYSVSQDKNSKHRALHITKPGPDLSGDYTCLVSSFNNEDRRTKSMLVFVPEKNLDLRQERIGEEVLQVLCSAEGVFPKPDMSLLMGSSEVNGSLVTVEERDGLFDIKARANIPALISPEEFSCELRIPKANYTVRKEAVYYPGAYGTALAPSGFLLFAILCSKGIFLLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ACS0</accession>
    <name>A0A5N4ACS0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tyr recombinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_11955</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0795116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ACS0"/>
    <dbReference type="InParanoid" id="A0A5N4ACS0"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00397">
        <property type="entry name" value="DNA_BRE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="entry name" value="Intergrase catalytic core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050090">
        <property type="entry name" value="Tyrosine_recombinase_XerCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30349:SF41">
        <property type="entry name" value="INTEGRASE_RECOMBINASE PROTEIN MJ0367-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30349">
        <property type="entry name" value="PHAGE INTEGRASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0795116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="203" mass="22367" checksum="E35B081D105DCB27" modified="2020-02-26" version="1" fragment="single">VVAIFGLFGACRRIEFYNLCVSDVQEEGAVFVVNLKDTKTHRPRTFTILNDDSMNYTELIKKYINLRPKHVKIEKFFLFYGAGKCTCNPIGINTFGQIPRKIAKYLNLPNADQFTGHSFRRTSATILADSGADIRTLKRHGDWKSDAVAEGCQRIRDLASSSTISVSGITSASSTTNECVLQSSSGISISGNSNCTITININK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ACT8</accession>
    <name>A0A5N4ACT8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Kelch-like protein diablo</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PPYR_11960</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">1611_PpyrPB1</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. May have a role in synapse differentiation and growth.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the KEAP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0795121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ACT8"/>
    <dbReference type="InParanoid" id="A0A5N4ACT8"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.80:FF:000024">
        <property type="entry name" value="Kelch-like ECH-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.420:FF:000001">
        <property type="entry name" value="Kelch-like family member 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000001">
        <property type="entry name" value="Kelch-like family member 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017096">
        <property type="entry name" value="BTB-kelch_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412:SF401">
        <property type="entry name" value="FI11917P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412">
        <property type="entry name" value="KELCH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037037">
        <property type="entry name" value="Kelch-like_protein_gigaxonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="BTB" evidence="14">
        <location>
            <begin position="63"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00043912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAB0795121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="610" mass="68669" checksum="19A812C4DA5672DF" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ADG7</accession>
    <name>A0A5N4ADG7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_12216</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0795377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4ADG7"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01099">
        <property type="entry name" value="PAN_AP_HGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01855">
        <property type="entry name" value="YqeH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056953">
        <property type="entry name" value="CUT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052807">
        <property type="entry name" value="Mito_transl_resp_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46406">
        <property type="entry name" value="NITRIC OXIDE-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46406:SF1">
        <property type="entry name" value="NITRIC OXIDE-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25057">
        <property type="entry name" value="CUT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00473">
        <property type="entry name" value="PAN_AP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00241">
        <property type="entry name" value="ZP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57414">
        <property type="entry name" value="Hairpin loop containing domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51034">
        <property type="entry name" value="ZP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024270248" description="G domain-containing protein" evidence="1">
        <location>
            <begin position="16"/>
            <end position="1374"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="2">
        <location>
            <begin position="20"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="2">
        <location>
            <begin position="112"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="ZP" evidence="3">
        <location>
            <begin position="297"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0795377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1374" mass="156349" checksum="F61DBD9D10566401" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-06-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AH07</accession>
    <name>A0A5N4AH07_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_10686</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AH07"/>
    <dbReference type="InParanoid" id="A0A5N4AH07"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024294716" evidence="1">
        <location>
            <begin position="20"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0796625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="634" mass="75767" checksum="118417B5D955DAD9" modified="2020-02-26" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AIT1</accession>
    <name>A0A5N4AIT1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Protein krueppel</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PPYR_08190</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">1611_PpyrPB1</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AIT1"/>
    <dbReference type="InParanoid" id="A0A5N4AIT1"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002349">
        <property type="entry name" value="Zinc finger and BTB domain-containing 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000557">
        <property type="entry name" value="zinc finger and SCAN domain-containing protein 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000060">
        <property type="entry name" value="zinc finger protein 436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000145">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001289">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012934">
        <property type="entry name" value="Znf_AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF49">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07776">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00868">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51915">
        <property type="entry name" value="ZAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZAD" evidence="15">
        <location>
            <begin position="14"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="180"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="208"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="236"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="264"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="293"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="321"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="350"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="382"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="410"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="438"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="466"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAB0797196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="490" mass="55680" checksum="7FFB2FB54E62E807" modified="2020-02-26" version="1">MESFVEYEHVHIEEVCRLCLNKHDQMSLICDSGVADLLLECASIQVTPDNGLYNLVCHQCANDVSRWYVFKQQVVRSFEIGRWLLQKKVKNDVNFVFDTSSVPHDTHSEHSNSVIEDEDELKDLLNQRDAGFAPSSSTKLTSDLSSVIEVIESVALDNCNITSTSSVTTGPKRKKSLEELLCVTCGKQCTSTNSYNRHLKTHDDSRPFICSKCDKPFKTSQVLAEHMKRHYDDRRHKCEICAQKFYAKASLNDHLRSHTGERPFKCDVCNRTFATKAILRQHSIIHTVRDRKFQCDICDKFLLTAGSLETHKRKHSGVKPFQCSGCNKSFFTKEAMQRHFGAIHDTDNNFLCSVCSKVCSTKVHLNNHMKKKHLGLGLPPNAVCTECGKQCGSAAELKVHVRVHTGERPYVCDICQKRFIAKGNLNSHKQRHLGRKPFLCNHCGKAFGERSTLKVHERIHTGEHPYSCNVCGKAYIQSSALRTHMKSHWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AIY5</accession>
    <name>A0A5N4AIY5_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_08281</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AIY5"/>
    <dbReference type="InParanoid" id="A0A5N4AIY5"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="entry name" value="Intergrase catalytic core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040350">
        <property type="entry name" value="TMEM272"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33444:SF2">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33444">
        <property type="entry name" value="SI:DKEY-19B23.12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="167"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0797287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="248" mass="27968" checksum="C659FA8BEECE6FAC" modified="2020-02-26" version="1">MKSVSETMQSSNQSVPAFSPPPLNNASKLQQESEIRTNVDEFRLKVQKPAIGTTVIVYLILNIVMFIVGVSTTKDCPIKPIIPVYLAVAGALGIITKLLPVVNYKFFENVLIEKLVYALLIIEFVWMITGSVWIYSIYEPPYQETSNQLYCNKTAYLLAFWLLTLNYIFFLLFIIMSCCAVCCICASVMVLLIIGYSGASRREELLNIHMTDIAHTDNNILIRITKTKNNIQRQFAISNPHCAVNKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AJ13</accession>
    <name>A0A5N4AJ13_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DM10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PPYR_08339</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="InParanoid" id="A0A5N4AJ13"/>
    <dbReference type="OrthoDB" id="10255210at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043014">
        <property type="term" value="F:alpha-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060285">
        <property type="term" value="P:cilium-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000281">
        <property type="term" value="P:mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="EF-hand domain (C-terminal) containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EF-hand domain containing 1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="EF-hand domain containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="DM10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040193">
        <property type="entry name" value="EFHC1/EFHC2/EFHB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12086">
        <property type="entry name" value="EF-HAND DOMAIN C-TERMINAL CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12086:SF9">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06565">
        <property type="entry name" value="DM10_dom"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00676">
        <property type="entry name" value="DM10"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51336">
        <property type="entry name" value="DM10"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="DM10" evidence="7">
        <location>
            <begin position="88"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="DM10" evidence="7">
        <location>
            <begin position="236"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="DM10" evidence="7">
        <location>
            <begin position="413"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="364"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0797345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="756" mass="87627" checksum="6DB52CAB526B1E06" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AJ17</accession>
    <name>A0A5N4AJ17_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ubiquitin-conjugating enzyme E2 J2</fullName>
            <ecNumber evidence="2">2.3.2.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PPYR_08305</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">1611_PpyrPB1</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the covalent attachment of ubiquitin to other proteins. Seems to function in the selective degradation of misfolded membrane proteins from the endoplasmic reticulum (ERAD). In cooperation with the GATOR2 complex, catalyzes 'Lys-6'-linked ubiquitination of NPRL2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="2"/>
    <dbReference type="EMBL" id="VVIM01000006">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="1158011at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23799">
        <property type="entry name" value="UBCc_UBE2J"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="UBC core" evidence="14">
        <location>
            <begin position="8"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00073320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAB0797311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="224" mass="25552" checksum="75B0D0C3CC2E9865" modified="2020-02-26" version="1">MSNRKSNSATARLKQDYLRLKKDPVPYITAEPLPSNILEWHYVVTGPESTPYDGGFYHGKLIFPKEFPFKPPSIYMITPNGRFKTNTRLCLSISDFHPDTWNPAWSVSTILTGLLSFMNEKSPTMGSIDTTDYEKRSLAFKSLEFNLRNRQFCELFPDIVTEIQAELEKRVALNKSVENQNQNQQAQESSNLQSILTNIIVLIGFAAFAFTVKFVMKTSYADSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AJN5</accession>
    <name>A0A5N4AJN5_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PPYR_08558</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AJN5"/>
    <dbReference type="InParanoid" id="A0A5N4AJN5"/>
    <dbReference type="OrthoDB" id="550424at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000016">
        <property type="entry name" value="DnaJ (Hsp40) homolog, subfamily A, member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.230.10:FF:000001">
        <property type="entry name" value="DnaJ subfamily A member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000003">
        <property type="entry name" value="DnaJ subfamily A member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044713">
        <property type="entry name" value="DNJA1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43888">
        <property type="entry name" value="DNAJ-LIKE-2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0488">Methylation</keyword>
    <keyword evidence="8" id="KW-0636">Prenylation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="11">
        <location>
            <begin position="5"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="12">
        <location>
            <begin position="128"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="9">
        <location>
            <begin position="128"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="374"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAB0797565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="408" mass="45683" checksum="3B5896EC037AEEDF" modified="2020-02-26" version="1">MADNKLYDILGVSRSSSDGEIKKAYRKLAKEFHPDKNPEEGHRFKEISYAYEVLSDPKKRQVYDKYGLKGMQEGGMQEGGFGGAEDILSRIFGQDIFGGFGMGGMRRRQRGEDTVHPLKVTLEDMYNGKTAKLQLSKNVICATCSGKGSKSDVVATCRACKGSGIKVTYRQLGPTMSQQMQSRCPQCLGEGEIINEKDRCGTCRGRKVCNETKIIEVHVDKGMKQNQKIFFRGEGDQQPDVEPGDVVIVLQQKPHEEFQRNEDDLHLNHVITVTEALCGFSFVVHQLDGRDLLIKHTAGDVVKPGDVRMIPGEGMPHYKNPFEKGNMYITFEVRFPDNHFANEMQLRELENALPPRTPFTMPTGDHVEEVDMHEYDPNDKNASGGRGEAYDSDEEHVHAGPGVQCAHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AKS1</accession>
    <name>A0A5N4AKS1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glutamate decarboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PPYR_08910</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the group II decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AKS1"/>
    <dbReference type="InParanoid" id="A0A5N4AKS1"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004351">
        <property type="term" value="F:glutamate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009449">
        <property type="term" value="P:gamma-aminobutyric acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45677:SF10">
        <property type="entry name" value="GLUTAMATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45677">
        <property type="entry name" value="GLUTAMATE DECARBOXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0797917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="603" mass="68390" checksum="ECACF518FD952F51" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2024-03-27" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AKZ3</accession>
    <name>A0A5N4AKZ3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Lipid-binding serum glycoprotein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_09018</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AKZ3"/>
    <dbReference type="InParanoid" id="A0A5N4AKZ3"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038602">
        <property type="entry name" value="Mite_allergen_7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020234">
        <property type="entry name" value="Mite_allergen_group-7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16984">
        <property type="entry name" value="Grp7_allergen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024459363" description="Lipid-binding serum glycoprotein N-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0798025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="250" mass="28793" checksum="680D72E465F38DB5" modified="2020-02-26" version="1">MKLIQLCLIATFLGVATSNTIQPRTYNFTTFNFKQIITKNDLEQLQRHSRSEQVAVMNEYIDEFLEELNEFLILQGMDPVSLPDQVKRFQWTIFWGEVSLKEGWLQGVGTIQRNGDVTIKYEYPTMRVIFPLKFGHLHISYDYLAQFTYLGPKGLMSGSVKGTQFYFDLEVDMATLLVRLNKYDLEDLGSISLTFHGGIFEWFANMLIWVVKPILKPILQLVLYNFTHGTIGGLIETYNALVNQILGNIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ALA0</accession>
    <name>A0A5N4ALA0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HotDog ACOT-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PPYR_09128</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acyl coenzyme A hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ALA0"/>
    <dbReference type="InParanoid" id="A0A5N4ALA0"/>
    <dbReference type="OrthoDB" id="331699at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03442">
        <property type="entry name" value="BFIT_BACH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033120">
        <property type="entry name" value="HOTDOG_ACOT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12655">
        <property type="entry name" value="ACYL-COA THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12655:SF0">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51770">
        <property type="entry name" value="HOTDOG_ACOT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="HotDog ACOT-type" evidence="5">
        <location>
            <begin position="97"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="HotDog ACOT-type" evidence="5">
        <location>
            <begin position="299"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0798135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="443" mass="50972" checksum="470EA8D42A1B8A7B" modified="2020-02-26" version="1">MSLYFFINNYIRRPKPCNFAMQIIVRSILHKNDRTKAINVGTMDHVATEVETIMGVDNKSYDPHDTGFQSRKKLTQFMAKNQKELPIRTIDDSFVYATIPLSSDPQIRIKYTAIMGTIRIGRLLEDMDMFAVYVCLRHILNPKMPKNEPTPYIVVTVLVDKINLTSVITKHDKDIRIFGHITWVGTSSLEVVVWLEQLDGKQSHLLLSAVFMMAVRESTTMKAAIINAVKATTPEEQKLIDGGKIRKEERIRTLAKQLTKVIPNEKEQEILHELFMRTLNVNEGVFLKQVLPSNCDWMEKYTLSNLIVVHPEHRNLHNNVFGGFIMRAALEVSFGLGYLFTNSRPLFKTISDINFNKPISLNSLIHMHAYLVCTKGKFYQISVHTNTWDTKAAQNFTSNTFHFTYESVSNVKEIFPKTYRESMTYIDGYRQLVAAINSHDRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ALP5</accession>
    <name>A0A5N4ALP5_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_09227</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ALP5"/>
    <dbReference type="InParanoid" id="A0A5N4ALP5"/>
    <dbReference type="OrthoDB" id="6247875at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="165"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0798234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="230" mass="24245" checksum="E2F21680A31F13C5" modified="2020-02-26" version="1">MAASSMTQSMASYYNPSAAYGSLSAASIAAAAAAQQSMSAGLTSPAQVVSSMDAMKYSMEADKYRSAYMPPSSLAMSMYSDPKYMDTSSKSYLERGYLDSTSALTKAYFESSKMYMDGKYNPDSARHYSLDIGKMYSDASPTMPSNLASPKSSDSPDTKPERQDGTSSSSSTTTSSAGASPGGLPGYYPGSALQQNSAMPSGLLPMSQYPGQYSAQGPAGEFRRPLTVIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AM69</accession>
    <name>A0A5N4AM69_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Adenylate cyclase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PPYR_09410</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AM69"/>
    <dbReference type="InParanoid" id="A0A5N4AM69"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032628">
        <property type="entry name" value="AC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45627:SF16">
        <property type="entry name" value="ADENYLATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45627">
        <property type="entry name" value="ADENYLATE CYCLASE TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16214">
        <property type="entry name" value="AC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="167"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="233"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="262"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="Adenylate cyclase N-terminal" evidence="5">
        <location>
            <begin position="125"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="41"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="57"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0798417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="367" mass="41705" checksum="A1F68E30240B8DB5" modified="2020-02-26" version="1">MLKSLSSESDKREWKRRFSLKEGRKRDTELSIRRGCNRRWTSLRQHTKTDNLRLTEPSTPSSASTTSPFIDPPRKSNWQVIEHFGSSSKVGSLRSYTIRENGTAPSSTSDKEGLDVHQLVTNKKSSTSIAYQIKKIFKNICTTPQFSDPQVEMLYQRYFLKMNQSNMTSLISLLLLFCVGIFILTSIDLLPKESRVTSDRLNKLLGFLCTSGSCVVIYGILLTILSRPAMNEVYLIIISYFILSTFLALQICTLIYSGWERPIAGTIITLTCTYLTYALLPIRLKDALLSGFVLAGIDILSLIYLSLRSTSEIESCVIILMCGNIVGTCTHYPREIAQRKAFLETRQCIEARLKIQRENQQQVRNCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AMW2</accession>
    <name>A0A5N4AMW2_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Afadin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PPYR_09606</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="interactions" value="445"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AMW2"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050839">
        <property type="term" value="F:cell adhesion molecule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032880">
        <property type="term" value="P:regulation of protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22711">
        <property type="entry name" value="FHA_AFDN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15471">
        <property type="entry name" value="Myo5p-like_CBD_afadin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06789">
        <property type="entry name" value="PDZ_AFDN-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01781">
        <property type="entry name" value="RA2_Afadin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000032">
        <property type="entry name" value="Afadin isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028842">
        <property type="entry name" value="Afadin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037977">
        <property type="entry name" value="CBD_Afadin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002710">
        <property type="entry name" value="Dilute_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10398">
        <property type="entry name" value="AFADIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10398:SF2">
        <property type="entry name" value="AFADIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00788">
        <property type="entry name" value="RA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01132">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00314">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51126">
        <property type="entry name" value="DILUTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-associating" evidence="4">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-associating" evidence="4">
        <location>
            <begin position="169"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Dilute" evidence="5">
        <location>
            <begin position="547"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="3">
        <location>
            <begin position="871"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="81"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="260"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="403"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1522"/>
            <end position="1608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1625"/>
            <end position="1700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1713"/>
            <end position="1742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1766"/>
            <end position="1798"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1922"/>
            <end position="1947"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1970"/>
            <end position="2068"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2102"/>
            <end position="2177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2288"/>
            <end position="2321"/>
        </location>
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    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="86"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1522"/>
            <end position="1536"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1573"/>
            <end position="1590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1591"/>
            <end position="1608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1625"/>
            <end position="1655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
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            <end position="1680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1768"/>
            <end position="1781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
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            <end position="1992"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2014"/>
            <end position="2025"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2044"/>
            <end position="2068"/>
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    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
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            <end position="2116"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="2120"/>
            <end position="2131"/>
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    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="2160"/>
            <end position="2172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2295"/>
            <end position="2310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0798613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2321" mass="259800" checksum="A107702A33D48F30" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2024-10-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AMY3</accession>
    <name>A0A5N4AMY3_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_09670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="InParanoid" id="A0A5N4AMY3"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF147">
        <property type="entry name" value="CHOLINE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0798677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="93" mass="9894" checksum="7B18B97FB399F12C" modified="2020-02-26" version="1" fragment="single">MEFASPCPVSLTGPPSHMFMTLINTIMTSQCLLSPANLFPSDHATHLKDGDQFDFIVVGGGSAGSRVASRLSENPKWKVLLLEAGGYPSANTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AN71</accession>
    <name>A0A5N4AN71_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PPYR_06636</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">1611_PpyrPB1</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Microsome membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0798756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AN71"/>
    <dbReference type="InParanoid" id="A0A5N4AN71"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050476">
        <property type="entry name" value="Insect_CytP450_Detox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292:SF54">
        <property type="entry name" value="CYP9F3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 14" id="KW-0349">Heme</keyword>
    <keyword evidence="11 14" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0492">Microsome</keyword>
    <keyword evidence="12" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="14">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAB0798756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="472" mass="54994" checksum="55221413E56E6DBA" modified="2020-02-26" version="1">MWFLVIFPVLIITLYKVRKIYTYWKGRGVPYCVHPLHCFGLFSENALRINCYSDVFEELYYKFKNKRYIGFYNFFQPVLLIRDPNLLKRICVKDYHAFSVHSEAIPLNLDEQWSKNMYAETNTQRWQKLRTSMTPSFTSNKLKSSFPAVEQFAIEFVNYLRESIDKNVTVNMLEIIRRVLSDITVNAYFGVKCDSLREPKNIVHLMVHEAMTLPCFHGFTHLCSRVCPKLLQLLGVKVYKASVQNFFAEMMERRLQLEFENGFKPYDIITALPELQGVKFSNTEKLNRSLIDDITGHAFLLTFAGYETTVTTLMSLLYELTVNDVVQENLYRDIIQTLDKYNGNVCYESVKAMEYLESAIEEVLRLHPPAPVIDRLATVNYEIKAEHPNEEDVVIEKGTPIWILAKAIQNDADYFPDPKKFNPDRFLSKNRHTVAQYTNIPIGAGPRSCPGKNTRFRTPRKMPQTHYAVIED</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AQB1</accession>
    <name>A0A5N4AQB1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Regulatory protein zeste</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_07333</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in transvection phenomena (= synapsis-dependent gene expression), where the synaptic pairing of chromosomes carrying genes with which zeste interacts influences the expression of these genes. Zeste binds to DNA and stimulates transcription from a nearby promoter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Self-associates forming complexes of several hundred monomers.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AQB1"/>
    <dbReference type="InParanoid" id="A0A5N4AQB1"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028002">
        <property type="entry name" value="Myb_DNA-bind_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23098">
        <property type="entry name" value="AGAP001331-PA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23098:SF16">
        <property type="entry name" value="REGULATORY PROTEIN ZESTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13873">
        <property type="entry name" value="Myb_DNA-bind_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Myb/SANT-like DNA-binding" evidence="6">
        <location>
            <begin position="9"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0799453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="313" mass="35534" checksum="7501644AD303CE89" modified="2020-02-26" version="1">MSEKKKKERSANFSPTEIDLLVKLVSQHAKVIECKKTDAATWKDKENEWEQLALEYNSANSTCPRNVKSLKTKYECLKKDIKKKVALQKQSLYQTGGGASKDIIFTPTEEILISIITFSIQGLSSRSDCDQVINNENIKHSVVVSEPPDVELDIVEDIPIMDIDVILESDTTLLPPMPSVASTSQNFVAVELPSTSTTEPTVETNWAKWNPSSLRKPVSKSLKVTPKKNKMWATRKEAMENITNLSASKGDLIKLQCESIILENDQKKILQEINLKKAKLELQSMRLDVKNKLIEKKIKLEQLMYFRNRNKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ARD3</accession>
    <name>A0A5N4ARD3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Dynein heavy chain ATP-binding dynein motor region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PPYR_07767</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ARD3"/>
    <dbReference type="InParanoid" id="A0A5N4ARD3"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000598">
        <property type="entry name" value="Dynein cytoplasmic 2 heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.720">
        <property type="entry name" value="Region D6 of dynein motor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035706">
        <property type="entry name" value="AAA_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041658">
        <property type="entry name" value="AAA_lid_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042219">
        <property type="entry name" value="AAA_lid_11_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041228">
        <property type="entry name" value="Dynein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043160">
        <property type="entry name" value="Dynein_C_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004273">
        <property type="entry name" value="Dynein_heavy_D6_P-loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45703:SF22">
        <property type="entry name" value="DYNEIN CYTOPLASMIC 2 HEAVY CHAIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45703">
        <property type="entry name" value="DYNEIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12781">
        <property type="entry name" value="AAA_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18198">
        <property type="entry name" value="AAA_lid_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18199">
        <property type="entry name" value="Dynein_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03028">
        <property type="entry name" value="Dynein_heavy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynein heavy chain ATP-binding dynein motor region" evidence="3">
        <location>
            <begin position="85"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain region D6 P-loop" evidence="2">
        <location>
            <begin position="540"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain AAA lid" evidence="4">
        <location>
            <begin position="680"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain C-terminal" evidence="5">
        <location>
            <begin position="869"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="245"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF18198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF18199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0799887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1112" mass="127005" checksum="A2AF576913A35DFB" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ARV2</accession>
    <name>A0A5N4ARV2_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_07934</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0800054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ARV2"/>
    <dbReference type="InParanoid" id="A0A5N4ARV2"/>
    <dbReference type="OrthoDB" id="9974378at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47412">
        <property type="entry name" value="FI01434P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47412:SF1">
        <property type="entry name" value="FI01434P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13896">
        <property type="entry name" value="Glyco_transf_49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0800054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="448" mass="52290" checksum="E04F7509C4282DC5" modified="2020-02-26" version="1">MRCMSRTIYGKIKRLFLLYVTIGVLIVIIIFFLNRRPFLFSFSSVNNAKLYKYRKSYPGSYLEDYKPNNESYCNFMYNLPDEFSYEEEHLEYGPELGVNGSYKVLYNVIRAKQNLSDVAAVTYVTHITPDFVSYITEVVRYWEGPVSIAAFVPDSDADILTKQLIQLCQCLPSMSKVSVHYVFPKLYAPYVGKFLNAASPTDLCVITDTSNLITFRNRKGLIYPVNVSRNVARNAATTTLVLVSDVELIPSKHLASRFLEMILKFAKMSNFHFRHHVFVIPVFEVDNYESVPRSKKDLIQLVRREKAVYFHRHICSHCQKFPGLEQWLSQDSGKAVKIFSATKRIYPYHRWEPVYIGTKDEPLYSETLSWEGKQDKMTQMLEMCLMGYRFLILDGAFLVHWPGIKRKSPQSKSVSKWRYPHQLWNSRQYTAIVKRLSKKYPKNPKCKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ARW3</accession>
    <name>A0A5N4ARW3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_07944</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0800064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ARW3"/>
    <dbReference type="FunCoup" id="A0A5N4ARW3">
        <property type="interactions" value="785"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4ARW3"/>
    <dbReference type="OrthoDB" id="2962993at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05941">
        <property type="entry name" value="MCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF8">
        <property type="entry name" value="ACYL-COA SYNTHETASE FAMILY MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="2">
        <location>
            <begin position="9"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="3">
        <location>
            <begin position="388"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0800064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="482" mass="54262" checksum="75DB390892EB7D88" modified="2020-02-26" version="1">MGHLDVRTSVPVSSLHPQSMIEYFASDSESKLLITIPQYSELMHTVATNTKTTLMVLDNNFRESMVVKQNLKQDLGELQSRDVLNDNALIIYTSGTTGYPKGVVLTHNNITNQIETLVDAWRWTSNDAILHVLPLHHIHGLVNALLCPLYVGAKCVMLPKFDANDVWVHLLGIKTKPESPKISVFMAVPTVYMKLVEEYKASFEHDPKIHEYIKTNLRSKIRLMVSGSAPLPVPLYEKWLEITGHRLLERYGMSEIGMCLSQLYDSQREPGYVGVPLKGCSVRLTERDDDDNYKTLLECTGVNDNVKVRLNTIPVGDAVVGELHVCGNSVFKEYYNKPDVTRKEFTDDHWFKTGDTCQYSIEKKIFKILGRTNLDVIKTGGYKLSALEIETKILSHPNVVDCAVVGVPDKTWGQIVAALVVFDRDLPIDTLQTFLKHKMASYGIPKIFKVVKVIPKNIMGKVNKTELLSAFLAKEEKVCAKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ASE3</accession>
    <name>A0A5N4ASE3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cuticle protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_05997</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000004">
        <property type="protein sequence ID" value="KAB0800257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ASE3"/>
    <dbReference type="InParanoid" id="A0A5N4ASE3"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051217">
        <property type="entry name" value="Insect_Cuticle_Struc_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236:SF94">
        <property type="entry name" value="CCP84AA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236">
        <property type="entry name" value="STRUCTURAL CONTITUENT OF CUTICLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00947">
        <property type="entry name" value="CUTICLE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0193">Cuticle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0800257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="300" mass="31340" checksum="7E3EC84462D4ACCA" modified="2020-02-26" version="1">MKVIIIASILVAVNAGGLIAPLAPAPLLRGHLAPAPILRAAPIVAKSVAVADADFDPNPQYSYHYDIQDALTGDSKNHFETRNGDAVQGSYSLSEADGSRRIVEYTADPINGFNAVVHKEPAQVAYAAPVAKVAAPLASSDRKKVTNMKVIIIASILVAVNAGGLIAPLAPAPLLRGHLAPAPILRAAPIVAKSVAVADADFDPNPQYSYHYDIQDALTGDSKNHFETRNGDAVHGSYSLSEADGSRRIVEYTADPINGFNAVVHKEPAQVAYAAPVAKVAAPLAYAAPIAKAPLLHAIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ASN1</accession>
    <name>A0A5N4ASN1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_06094</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000004">
        <property type="protein sequence ID" value="KAB0800354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ASN1"/>
    <dbReference type="InParanoid" id="A0A5N4ASN1"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33939:SF1">
        <property type="entry name" value="DUF4371 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33939">
        <property type="entry name" value="PROTEIN CBG22215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0800354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="95" mass="11194" checksum="279DC98DCEFC077E" modified="2020-02-26" version="1">MNRGNFENWFKTQLVPNLPEKSLIIMDNASYHSGLLEKIPTKSWTKQRMIEWLGEKNIGYPEKAMKDQIWSIQIDTFMRFTCHCICKIISELPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ASZ1</accession>
    <name>A0A5N4ASZ1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">CUB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PPYR_06201</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000004">
        <property type="protein sequence ID" value="KAB0800461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ASZ1"/>
    <dbReference type="FunCoup" id="A0A5N4ASZ1">
        <property type="interactions" value="29"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4ASZ1"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000021">
        <property type="entry name" value="semaphorin-5B isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038877">
        <property type="entry name" value="THSD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16311">
        <property type="entry name" value="THROMBOSPONDIN TYPE I DOMAIN-CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16311:SF3">
        <property type="entry name" value="THROMBOSPONDIN TYPE-1 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01705">
        <property type="entry name" value="TSP1REPEAT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="CUB" evidence="10">
        <location>
            <begin position="461"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="715"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="989"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="715"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="729"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="762"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="782"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="820"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="995"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1032"/>
            <end position="1045"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0800461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1045" mass="115272" checksum="82642ACE14FAAF2E" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AT55</accession>
    <name>A0A5N4AT55_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Mitotic checkpoint protein BUB3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PPYR_06236</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">1611_PpyrPB1</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
            <location evidence="2">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the WD repeat BUB3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000004">
        <property type="protein sequence ID" value="KAB0800496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AT55"/>
    <dbReference type="FunCoup" id="A0A5N4AT55">
        <property type="interactions" value="1627"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AT55"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000047">
        <property type="entry name" value="Mitotic checkpoint protein bub3, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10971">
        <property type="entry name" value="MRNA EXPORT FACTOR AND BUB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="13" id="KW-0137">Centromere</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="9" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="11" id="KW-0469">Meiosis</keyword>
    <keyword evidence="7" id="KW-0498">Mitosis</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 16" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="16">
        <location>
            <begin position="94"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="16">
        <location>
            <begin position="239"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00037960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00040107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAB0800496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="332" mass="37383" checksum="1C34F8DFADDE02EE" modified="2020-02-26" version="1">MLIKSQTEYKVKSPPDDAISAVKFGPNTNQFLLVSSWDGNVRLYDVLANSLRHKYSHAGPVLDCCFTDAVHSYSGGLDSTLKSLDFNTTAETTVGTHNMPIRCVEYCQEVNGILTGSWDNFLKLWDPRAPICSGNYNQGDKVYTMSVCGEKLVVGTAGRKILVWDIRNMSYTLQKRESNLKYQTRAIRCFPNKQGFVLSSIEGRVAVEYLDTSPEIQKKKYAFKCHRIKEDGLERIYPVNAISFHPAYNTFATGGSDGYVNIWDGFNKKRLCQFHQYHTSITSLSFSHNGSILAIACSYFLEEDNPVSPLPEDAIYIRTVTDQETKPKQSNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2024-01-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AT66</accession>
    <name>A0A5N4AT66_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase A2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_02626</name>
        <name evidence="1" type="ORF">PPYR_06302</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000004">
        <property type="protein sequence ID" value="KAB0800562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0805656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AT66"/>
    <dbReference type="InParanoid" id="A0A5N4AT66"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13650">
        <property type="entry name" value="Asp_protease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0800562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0805656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="221" mass="24730" checksum="E815E00FEC562B8E" modified="2020-02-26" version="1">MIDVGPMSSRRFQEANRVKCLLDFVFSHVQGDERPHIRVNILGKEMLGLLDSGATRSVIGERGCKILRSTGLPLLKSEFSNITVANGQVCACVGILRVPIKLKETVKVIDLLVVPTLGQLLILGVDFWTQMGIVPNLRAKEWKFAAEGEVEVNSLDPVNSRQNLNLDQERRLSEAIECYFGHMPTSFSCTDLVEHKIELLDNVEPIKQRYYPVSPALLKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ATI3</accession>
    <name>A0A5N4ATI3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EML-like second beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_06270</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000004">
        <property type="protein sequence ID" value="KAB0800530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ATI3"/>
    <dbReference type="FunCoup" id="A0A5N4ATI3">
        <property type="interactions" value="216"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4ATI3"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055442">
        <property type="entry name" value="Beta-prop_EML-like_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051510">
        <property type="entry name" value="SKI8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44090:SF1">
        <property type="entry name" value="SUPERKILLER COMPLEX PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44090">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23414">
        <property type="entry name" value="Beta-prop_EML_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="77"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="EML-like second beta-propeller" evidence="4">
        <location>
            <begin position="126"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="171"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="204"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="246"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="288"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0800530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="324" mass="35581" checksum="EA4F7E23A06D6A3E" modified="2020-02-26" version="1">MYSLLHKKESAHNDSIWSCAWGRYSKEKTSNDQDGDHSRDSIASDDGGRDYIVTGGVDDLVKVWELEDDILKMKHELEGHSLGVISVAVSNNGKLCASSSLDSSMRLWDLQKGEKITTIDCGPVDLWTLAFSPDDKHIISGSQAGIVSVYSVETAKLEKSLDTTRGKFTLSIAYSPDGKYIASGAIDGFINIFDVDSNKLCRTLNGHAMPIRSLCFSPDSQLLLTASDDGHMKLYDVQHANVVGTLSGHASWVLSVSFSPDGKYFVSGSSDKTVKVWEVATKQCIHTFNEHNDQVWGVKFNPDNNKILSVSEDKSMNVYNCPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ATM6</accession>
    <name>A0A5N4ATM6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_06353</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000004">
        <property type="protein sequence ID" value="KAB0800613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ATM6"/>
    <dbReference type="InParanoid" id="A0A5N4ATM6"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061343">
        <property type="term" value="P:cell adhesion involved in heart morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007508">
        <property type="term" value="P:larval heart development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33395:SF22">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33395">
        <property type="entry name" value="TRANSCRIPTASE, PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0800613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="572" mass="65558" checksum="5C2C5ADE48C5D65B" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AU74</accession>
    <name>A0A5N4AU74_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_05279</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000003">
        <property type="protein sequence ID" value="KAB0800925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AU74"/>
    <dbReference type="FunCoup" id="A0A5N4AU74">
        <property type="interactions" value="2645"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AU74"/>
    <dbReference type="OrthoDB" id="342454at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000112">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042858">
        <property type="entry name" value="DNAJC8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15606:SF4">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15606">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 8/LIPOPOLYSACCHARIDE SPECIFIC RESPONSE-7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="51"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0800925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="248" mass="29274" checksum="54DA134049F1B9A5" modified="2020-02-26" version="1">MARNNAPITKEVEFNEFYTEVKEIEKRDSVLTPKQQIERLLRPGSTYFNLNPFEVLNVDPDTPLEDIKKSYRRLSILVHPDKNQDDAERSQQAFEVVSRAWKTLESEDSRQKCMDIIEEAKGRTDLMLVEKRKKARKEGKDSVPEDDPEKYKHAVYVLTMKLFADMERKRRDLAAKDQEERKRKREQEIEDEENQKAQKEWQKNFEESRQNRVDSWLTFQAGGSSKSKGKAPKKLKSFKPPKPKPESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AUD4</accession>
    <name>A0A5N4AUD4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sema domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_05291</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000003">
        <property type="protein sequence ID" value="KAB0800937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AUD4"/>
    <dbReference type="InParanoid" id="A0A5N4AUD4"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002116">
        <property type="term" value="C:semaphorin receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017154">
        <property type="term" value="F:semaphorin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030334">
        <property type="term" value="P:regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11236">
        <property type="entry name" value="Sema_plexin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000451">
        <property type="entry name" value="Plexin A4, B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031148">
        <property type="entry name" value="Plexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001627">
        <property type="entry name" value="Semap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036352">
        <property type="entry name" value="Semap_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22625">
        <property type="entry name" value="PLEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22625:SF70">
        <property type="entry name" value="PLEXIN A, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01403">
        <property type="entry name" value="Sema"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00630">
        <property type="entry name" value="Sema"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101912">
        <property type="entry name" value="Sema domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51004">
        <property type="entry name" value="SEMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0221">Differentiation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024421003" description="Sema domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="Sema" evidence="4">
        <location>
            <begin position="6"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0800937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="368" mass="40313" checksum="CCF1B92656B18825" modified="2020-02-26" version="1" fragment="single">MKRHLITILLTVAVAAASSDIVRSFTDPAVERFNHLVVDKNTGRVYIGAVNRLYQLSPELELVIAEVTGPELDSDECSVLECTTSVNKKLTDNVNKALVIDYTTTRLISCGSLFQGICSIRNLHNISDAAQEVREAVVANNATASTVAFIAPGPPNPPVSQVMYVGVTFTLGSPYRSEVPAVSSRSLDKGKMFTIAQTAVTTGTRMFVNSLARERYPITYVYGFSSERFSYFLTTQMKHTTSSQFITKLVRVCQDDENYYSYTEIPIDCISEAQGGRKYNLVQAAYVGKAGSDLAGDLGITAQDDVLFAVFSESEPLQVNRPSDLSALCVYSLKAIRRKFMQNIKTCFNGVGQRGLDFISPSHPCVPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AUR2</accession>
    <name>A0A5N4AUR2_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Vitellogenin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PPYR_05410</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000003">
        <property type="protein sequence ID" value="KAB0801056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A5N4AUR2">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AUR2"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045735">
        <property type="term" value="F:nutrient reservoir activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.50.20:FF:000007">
        <property type="entry name" value="von Willebrand factor type D domaincontaining protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.230.10">
        <property type="entry name" value="Lipovitellin, beta-sheet shell regions, chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.80.10">
        <property type="entry name" value="Lipovitellin-phosvitin complex, chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.50.20">
        <property type="entry name" value="Lipovitellin. Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.20">
        <property type="entry name" value="Vitellinogen, superhelical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015819">
        <property type="entry name" value="Lipid_transp_b-sht_shell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009454">
        <property type="entry name" value="Lipid_transpt_open_b-sht"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011030">
        <property type="entry name" value="Lipovitellin_superhlx_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015816">
        <property type="entry name" value="Vitellinogen_b-sht_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015255">
        <property type="entry name" value="Vitellinogen_open_b-sht"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015817">
        <property type="entry name" value="Vitellinogen_open_b-sht_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050733">
        <property type="entry name" value="Vitellogenin/Apolipophorin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001747">
        <property type="entry name" value="Vitellogenin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001846">
        <property type="entry name" value="VWF_type-D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23345:SF15">
        <property type="entry name" value="VITELLOGENIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23345">
        <property type="entry name" value="VITELLOGENIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06448">
        <property type="entry name" value="DUF1081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09172">
        <property type="entry name" value="Vit_open_b-sht"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01347">
        <property type="entry name" value="Vitellogenin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00094">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01169">
        <property type="entry name" value="DUF1943"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00638">
        <property type="entry name" value="LPD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00216">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56968">
        <property type="entry name" value="Lipovitellin-phosvitin complex, beta-sheet shell regions"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48431">
        <property type="entry name" value="Lipovitellin-phosvitin complex, superhelical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51211">
        <property type="entry name" value="VITELLOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51233">
        <property type="entry name" value="VWFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="7" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0758">Storage protein</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024342155" description="Vitellogenin domain-containing protein" evidence="11">
        <location>
            <begin position="25"/>
            <end position="4184"/>
        </location>
    </feature>
    <feature type="domain" description="Vitellogenin" evidence="12">
        <location>
            <begin position="48"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="13">
        <location>
            <begin position="3611"/>
            <end position="3781"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAB0801056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="4184" mass="477181" checksum="BBF604B89FCFE454" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AVC4</accession>
    <name>A0A5N4AVC4_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PPYR_05633</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000003">
        <property type="protein sequence ID" value="KAB0801279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AVC4"/>
    <dbReference type="InParanoid" id="A0A5N4AVC4"/>
    <dbReference type="OrthoDB" id="10025028at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057926">
        <property type="entry name" value="QRICH1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021893">
        <property type="entry name" value="ZMYM2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051284">
        <property type="entry name" value="ZnF_MYMT-QRICH1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45736:SF1">
        <property type="entry name" value="WITHOUT CHILDREN, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45736">
        <property type="entry name" value="ZINC FINGER MYM-TYPE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12012">
        <property type="entry name" value="DUF3504"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25561">
        <property type="entry name" value="QRICH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="QRICH1-like" evidence="5">
        <location>
            <begin position="44"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="ZMYM2-like/QRICH1 C-terminal" evidence="4">
        <location>
            <begin position="123"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0801279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="294" mass="34967" checksum="885F1FB9994FB7FF" modified="2020-02-26" version="1">MDGEKPAVMWLHHIGGSHGRAATILERFIDATTDVPRLHSLEGYSSYELSDHLANFIRVQSLLKEYSPDSLYYFCLGIQWYLHACGRVGNIFFHDTFMDCRKLLNQFALKFIGSYYDDPIYISTCVSEKYLWESDHLSPKWPHTLLWTVVYLVMKYFKLSTVEEHKALKMKNLFKRETRDRVKGKQSYFFYFLQESRGTQYCKRQLLPDKNPSRCPVEIMKIYLSKCPRLPKMRDSCLYLKPISRCDLESQPYWFTQEELPDKDLAEMLNRFKMVSEITELFVKDRITSLIPWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AVD9</accession>
    <name>A0A5N4AVD9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutathione-specific gamma-glutamylcyclotransferase</fullName>
            <ecNumber evidence="2">4.3.2.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_05534</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>glutathione = L-cysteinylglycine + 5-oxo-L-proline</text>
            <dbReference type="Rhea" id="RHEA:47724"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58402"/>
            <dbReference type="ChEBI" id="CHEBI:61694"/>
            <dbReference type="EC" id="4.3.2.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the gamma-glutamylcyclotransferase family. ChaC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.7" evidence="2"/>
    <dbReference type="EMBL" id="VVIM01000003">
        <property type="protein sequence ID" value="KAB0801180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AVD9"/>
    <dbReference type="FunCoup" id="A0A5N4AVD9">
        <property type="interactions" value="109"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AVD9"/>
    <dbReference type="OrthoDB" id="1933483at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061928">
        <property type="term" value="F:glutathione specific gamma-glutamylcyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.10">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006840">
        <property type="entry name" value="ChaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036568">
        <property type="entry name" value="GGCT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12192">
        <property type="entry name" value="CATION TRANSPORT PROTEIN CHAC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12192:SF26">
        <property type="entry name" value="GLUTATHIONE-SPECIFIC GAMMA-GLUTAMYLCYCLOTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04752">
        <property type="entry name" value="ChaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110857">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0801180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="251" mass="28376" checksum="E8014033F4647F9C" modified="2020-02-26" version="1">MEPTSVVVELQDIVNENDKKSLWIFGYGSLCWNPGFSFEKAVAGTIHGYSRKFWQGNSTHRGTEEKPGRVVTLVKEKGSVVHGLAFQISGEAALSYLNKRECKLGGYVVEFARFYPRARNISFNTILYIATAQNELWLGDAPASDIADQIVESCGASGHNVEYLIRLAAFMHYHFPNEKDDHLFAIERLVIMKLRDRKACLKALMGDERETITFISNASLDDLQRDGLEERQNSFQYAANVPVKIMRCLNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AVR2</accession>
    <name>A0A5N4AVR2_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_05773</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000003">
        <property type="protein sequence ID" value="KAB0801419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AVR2"/>
    <dbReference type="FunCoup" id="A0A5N4AVR2">
        <property type="interactions" value="672"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AVR2"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06705">
        <property type="entry name" value="PDZ_MAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1480.20:FF:000001">
        <property type="entry name" value="microtubule-associated serine/threonine-protein kinase 4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000008">
        <property type="entry name" value="microtubule-associated serine/threonine-protein kinase 4 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1480.20">
        <property type="entry name" value="MAST3 pre-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015022">
        <property type="entry name" value="MAST_pre-PK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023142">
        <property type="entry name" value="MAST_pre-PK_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051067">
        <property type="entry name" value="NHER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14191:SF27">
        <property type="entry name" value="MICROTUBULE ASSOCIATED SERINE_THREONINE KINASE FAMILY MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14191">
        <property type="entry name" value="PDZ DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08926">
        <property type="entry name" value="DUF1908"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140482">
        <property type="entry name" value="MAST3 pre-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="608"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="150"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="469"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="696"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="854"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="981"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="150"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="469"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="714"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="759"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="778"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="854"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="910"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="981"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1012"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1054"/>
            <end position="1071"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0801419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1104" mass="120279" checksum="9DB1448CABA0C68F" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AYE8</accession>
    <name>A0A5N4AYE8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Carboxylesterase type B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_04376</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>acetylcholine + H2O = choline + acetate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17561"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15355"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="EC" id="3.1.1.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AYE8"/>
    <dbReference type="InParanoid" id="A0A5N4AYE8"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003990">
        <property type="term" value="F:acetylcholinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006581">
        <property type="term" value="P:acetylcholine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019695">
        <property type="term" value="P:choline metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000997">
        <property type="entry name" value="Cholinesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF13">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00878">
        <property type="entry name" value="CHOLNESTRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="8">
        <location>
            <begin position="6"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0802190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="213" mass="24678" checksum="F83F09687C66B693" modified="2020-02-26" version="1">MSRLERDAIVFQYTDWEHVNDGYLNQKMIADVVGDYFFICPTNYFAEAMAERGMKVYYYYFTHRTSTSLWGEWMGVMHGDEIEYVFGHPLNLSLQFNSRERELSLKMMRAFARFSNTGKPVTDDVNWPIYTKEHPQYFIFNADKTGIGRGPRATACAFWNNFLPRLRDNTGSGELPCEASVVGAVSSRSPRFITSAFSFVFYIFISALIVYIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AZ87</accession>
    <name>A0A5N4AZ87_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Hexosyltransferase</fullName>
            <ecNumber evidence="9">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PPYR_04656</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Golgi apparatus</location>
            <location evidence="1 9">Golgi stack membrane</location>
            <topology evidence="1 9">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the chondroitin N-acetylgalactosaminyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="9"/>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AZ87"/>
    <dbReference type="FunCoup" id="A0A5N4AZ87">
        <property type="interactions" value="95"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AZ87"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047238">
        <property type="term" value="F:glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008428">
        <property type="entry name" value="Chond_GalNAc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051227">
        <property type="entry name" value="CS_glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12369">
        <property type="entry name" value="CHONDROITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12369:SF45">
        <property type="entry name" value="HEXOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05679">
        <property type="entry name" value="CHGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="31"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAB0802470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="550" mass="62465" checksum="26996DD25266F4EC" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B1H6</accession>
    <name>A0A5N4B1H6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DDE-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_00210</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B1H6"/>
    <dbReference type="InParanoid" id="A0A5N4B1H6"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF74">
        <property type="entry name" value="POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
        <property type="entry name" value="HTH_psq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH psq-type" evidence="4">
        <location>
            <begin position="22"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="DDE-1" evidence="3">
        <location>
            <begin position="207"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="487"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="487"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0803240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="566" mass="64598" checksum="2625EA3B256C66A3" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B1R8</accession>
    <name>A0A5N4B1R8_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_00476</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B1R8"/>
    <dbReference type="InParanoid" id="A0A5N4B1R8"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0803506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="300" mass="34762" checksum="E0F5F82B934C1CB4" modified="2020-02-26" version="1">MSASPRIKILQNIVVVPAKEADVQENVLIEDICKDLNCPDFDYSLLEEIFGDIECLNRQLIDAEKQLSRFFKILSIKRENNFCDLQWCHCQVEHLIERRAKLLADIQQLSVGNLRRHLKKSCRAQEPSPKKLKVTHDTQRFCDVCSEHVSSRDYVGHLRSVKHKNNSLAFSTEGVQVITSAFKSRIVSYRISANTQYINLKEFVESLADVIKKLVREQIDIMGSVKVNCELFGYFILESKDRGEVKSFNTRNQVLTISSDLSEWFKDIIEKLEVDATEFEHRESGINIQLFMPCLHNYLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B1Z5</accession>
    <name>A0A5N4B1Z5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tyr recombinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_00601</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B1Z5"/>
    <dbReference type="InParanoid" id="A0A5N4B1Z5"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00397">
        <property type="entry name" value="DNA_BRE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="entry name" value="Intergrase catalytic core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050090">
        <property type="entry name" value="Tyrosine_recombinase_XerCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30349:SF41">
        <property type="entry name" value="INTEGRASE_RECOMBINASE PROTEIN MJ0367-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30349">
        <property type="entry name" value="PHAGE INTEGRASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="4">
        <location>
            <begin position="104"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="556"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="556"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0803631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="576" mass="64783" checksum="D1D9A689B5D6B0C9" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B2H1</accession>
    <name>A0A5N4B2H1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Alpha-galactosidase</fullName>
            <ecNumber evidence="10">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PPYR_00560</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3 10">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the glycosyl hydrolase 27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="10"/>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B2H1"/>
    <dbReference type="InParanoid" id="A0A5N4B2H1"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019377">
        <property type="term" value="P:glycolipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016139">
        <property type="term" value="P:glycoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009311">
        <property type="term" value="P:oligosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14792">
        <property type="entry name" value="GH27"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000070">
        <property type="entry name" value="Alpha-galactosidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000197">
        <property type="entry name" value="Alpha-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002241">
        <property type="entry name" value="Glyco_hydro_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000111">
        <property type="entry name" value="Glyco_hydro_27/36_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035373">
        <property type="entry name" value="Melibiase/NAGA_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452:SF83">
        <property type="entry name" value="ALPHA-GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452">
        <property type="entry name" value="ALPHA-GALACTOSIDASE/ALPHA-N-ACETYLGALACTOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16499">
        <property type="entry name" value="Melibiase_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17450">
        <property type="entry name" value="Melibiase_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00740">
        <property type="entry name" value="GLHYDRLASE27"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00512">
        <property type="entry name" value="ALPHA_GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0458">Lysosome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024327922" description="Alpha-galactosidase" evidence="11">
        <location>
            <begin position="19"/>
            <end position="1213"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha galactosidase A C-terminal" evidence="12">
        <location>
            <begin position="1114"/>
            <end position="1203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAB0803590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1213" mass="139051" checksum="5D6D1214F3042C75" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B2Z6</accession>
    <name>A0A5N4B2Z6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Copper transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PPYR_00868</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Membrane</location>
            <topology evidence="1 5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B2Z6"/>
    <dbReference type="InParanoid" id="A0A5N4B2Z6"/>
    <dbReference type="OrthoDB" id="73901at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005375">
        <property type="term" value="F:copper ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007274">
        <property type="entry name" value="Cop_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483:SF27">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN CTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 31 COPPER TRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04145">
        <property type="entry name" value="Ctr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0186">Copper</keyword>
    <keyword evidence="5" id="KW-0187">Copper transport</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0803898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="204" mass="23082" checksum="C9E84802AD2FE81B" modified="2020-02-26" version="1">MHMTFWWDTNIPDLLFYGCNISSKGWLTLTCLILIALGILFEWLKLLQAKQKQRELIIRARQIRTVCPSSETSTLISHGEGTNSQKPSLFVRTKLLFCDACLWINIHVLGYILMLVIMVYNGWLIISLLIGSGIGYFLFGTQFIKITMQNFQTVRDTFCYMNCAEADLTNETEPIVEPSSSHCSSTSHGHTEGTVVVCVHPEPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B3L0</accession>
    <name>A0A5N4B3L0_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_01126</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B3L0"/>
    <dbReference type="InParanoid" id="A0A5N4B3L0"/>
    <dbReference type="OrthoDB" id="6802325at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0804156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="162" mass="18841" checksum="3015BD3A6BB23D5A" modified="2020-02-26" version="1">MLMYDNPDRFKTCSLRLLKDHMLEQICKYRKYDSEEASESGKERLQTPWGANMRELMEVWDTYTKLVNADKVLHTANAPGRPKKGSETQKKNEVEVARRIRDAALGTITQSCTNELQTVQEQRSTSDDGCQTPTARQHTKVATKRRTNKDEMYLHTYQRKPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-06-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B3Q9</accession>
    <name>A0A5N4B3Q9_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_00980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B3Q9"/>
    <dbReference type="InParanoid" id="A0A5N4B3Q9"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0804010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="107" mass="12169" checksum="085BC0C66299869C" modified="2020-02-26" version="1">MPNEVLSNPVRHIAHSRFSVSLILLVNYEIGQIEVYSSSNTANLHSNWKYSTYRPKAKFENCYLSELLADDMRLSFLDVSLLSLLDCDLKTVGGDVSTTLFTFLSFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B3V3</accession>
    <name>A0A5N4B3V3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial</fullName>
            <ecNumber evidence="12">1.14.15.45</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">2-methoxy-6-polyprenolphenol 4-hydroxylase</fullName>
            <ecNumber evidence="12">1.14.15.46</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">coq6</name>
        <name evidence="14" type="ORF">PPYR_01242</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">FAD-dependent monooxygenase required for two non-consecutive steps during ubiquinone biosynthesis. Required for the C5-ring hydroxylation during ubiquinone biosynthesis by catalyzing the hydroxylation of 4-hydroxy-3-(all-trans-polyprenyl)benzoic acid to 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoic acid. Also acts downstream of coq4, for the C1-hydroxylation during ubiquinone biosynthesis by catalyzing the hydroxylation of 2-methoxy-6-(all-trans-polyprenyl)phenol to 2-methoxy-6-(all-trans-polyprenyl)benzene-1,4-diol. The electrons required for the hydroxylation reaction are funneled indirectly to coq6 from NADPH via a ferredoxin/ferredoxin reductase system.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 2-methoxy-6-(all-trans-polyprenyl)phenol + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = a 2-methoxy-6-(all-trans-polyprenyl)benzene-1,4-diol + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O</text>
            <dbReference type="Rhea" id="RHEA:81183"/>
            <dbReference type="Rhea" id="RHEA-COMP:9551"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10858"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:62731"/>
            <dbReference type="ChEBI" id="CHEBI:84166"/>
            <dbReference type="EC" id="1.14.15.46"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 4-hydroxy-3-(all-trans-polyprenyl)benzoate + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = a 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoate + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O</text>
            <dbReference type="Rhea" id="RHEA:81195"/>
            <dbReference type="Rhea" id="RHEA-COMP:9514"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10930"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:64694"/>
            <dbReference type="ChEBI" id="CHEBI:78396"/>
            <dbReference type="EC" id="1.14.15.45"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="12">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of a multi-subunit COQ enzyme complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Mitochondrion inner membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the UbiH/COQ6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.15.45" evidence="12"/>
    <dbReference type="EC" id="1.14.15.46" evidence="12"/>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B3V3"/>
    <dbReference type="FunCoup" id="A0A5N4B3V3">
        <property type="interactions" value="1214"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4B3V3"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120538">
        <property type="term" value="F:2-methoxy-6-polyprenolphenol 4-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106364">
        <property type="term" value="F:4-hydroxy-3-all-trans-polyprenylbenzoate oxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000021">
        <property type="entry name" value="Ubiquinone biosynthesis monooxygenase COQ6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000086">
        <property type="entry name" value="Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03193">
        <property type="entry name" value="COQ6_monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018168">
        <property type="entry name" value="Ubi_Hdrlase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010971">
        <property type="entry name" value="UbiH/COQ6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051205">
        <property type="entry name" value="UbiH/COQ6_monooxygenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000689">
        <property type="entry name" value="UbQ_mOase_COQ6"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01989">
        <property type="entry name" value="COQ6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01988">
        <property type="entry name" value="Ubi-OHases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43876">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS MONOOXYGENASE COQ6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43876:SF7">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS MONOOXYGENASE COQ6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01304">
        <property type="entry name" value="UBIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0274">FAD</keyword>
    <keyword evidence="3 12" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9 12" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 12" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="domain" description="FAD-binding" evidence="13">
        <location>
            <begin position="39"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="13">
        <location>
            <begin position="327"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAB0804272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="465" mass="51353" checksum="66FE57166DD8F406" modified="2020-02-26" version="1">MTTYGIFSLQNCLKLRHCAKSNSNFLRYCSNASTSPKHYDIVISGGGMIGSTLACTLGKNSKLGTQRILLLESGKPTQWTVTDKFSNRVSALNQNTYNLLNNIGAWKHISSVRSAPVHNMQIWDAISDTVITFNQETSSQVVAHIVENGLLLDAVAKELSQVSNVEVRNEVKIKKYTFPQGNSQMVTIELANGEILTSNLLLGCDGFNSQVRQSMGVTFVSWKYDQKATVATLKFSEPVKNVTAWQRFLPTGPIALLPLSECYGSLVWCTAPDVADYNSKLSEEQFVNEVNEALWKVYPSNSIIQESTKTLNKFLEWFHLPSSNRQQLPPKIVEVEEGSIASFPLGFGHATHYVGHGVALVGDAAHRVHPLAGQGVNLGFGDVSTLNELLGEAAYSGREIGHINDLREYETRRQRHNVPTMIAIDGLHKLYSTDFLPVVLLRSLGLQFTNAINPLKMAFIDHAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B486</accession>
    <name>A0A5N4B486_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BED-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_01333</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B486"/>
    <dbReference type="InParanoid" id="A0A5N4B486"/>
    <dbReference type="OrthoDB" id="8912104at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47501:SF5">
        <property type="entry name" value="HAT C-TERMINAL DIMERISATION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47501">
        <property type="entry name" value="TRANSPOSASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0804363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="365" mass="40972" checksum="E6D0BE6998B937FD" modified="2020-02-26" version="1">MCEQEPSTSANFMIKDEDTIPCILNGKFFKIISTESSGKVRAKCLLCTTKENIISGSMKATTNFKLHIKRIHESALPEFEQFLAESRNKNKRKASVASSSSGTAMKQMKLFDPILQKLSKQKQLDKNIMQYVTCSMKPLSTVDDPYFIKIITDLNPELKTMSRRTLGRNIDKSYAETMQKLKTILQNINHVSTTADIWSTKHKSFMGVTAHWISQDDLVRHSCVLACRRFKGSHTYDKVAEMLYDITSDFGLRHDQLISTITDNGSNFVKAFAEHGIKLNIGESTDDEADEESEDHDTQGASEELSASFTIPDKDVITLPNHLRCASHTLNLLATTDFMNAIKNSAVSRIHYPALAKCTAIWNAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B5M9</accession>
    <name>A0A5N4B5M9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit protein mS26</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">28S ribosomal protein S26, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PPYR_01823</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS26 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B5M9"/>
    <dbReference type="FunCoup" id="A0A5N4B5M9">
        <property type="interactions" value="387"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4B5M9"/>
    <dbReference type="OrthoDB" id="5988811at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026140">
        <property type="entry name" value="Ribosomal_mS26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21035">
        <property type="entry name" value="28S RIBOSOMAL PROTEIN S26, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21035:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14943">
        <property type="entry name" value="MRP-S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="110"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0804853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="213" mass="25325" checksum="A601CDC87211EDC3" modified="2020-02-26" version="1">MFTRLNNAKLAITVEAFTTNYTNLQVYRWGKKPRWLPTAKTKMFRVAPRPQIPTEDYEELKRLHNNYRTQIKSLTGYFTEKYSTENIQQFDIEQHEKSIKDDFLKCTAINDEWNRQIKIQREERVAKELEESVNLAKQRLEERQQRQLLKLQAADVEVRRVIEDSKDFITPDKLDAAIEYALNNPVDYNFALDLDGNVYKGRNNDSVKFEIKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B6M3</accession>
    <name>A0A5N4B6M3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_02231</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the kindlin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0805261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B6M3"/>
    <dbReference type="FunCoup" id="A0A5N4B6M3">
        <property type="interactions" value="320"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4B6M3"/>
    <dbReference type="OrthoDB" id="10057618at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030055">
        <property type="term" value="C:cell-substrate junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005178">
        <property type="term" value="F:integrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13205">
        <property type="entry name" value="FERM_C_fermitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17095">
        <property type="entry name" value="FERM_F0_kindlins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17096">
        <property type="entry name" value="FERM_F1_kindlins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01237">
        <property type="entry name" value="PH_fermitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037843">
        <property type="entry name" value="Kindlin/fermitin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040790">
        <property type="entry name" value="Kindlin_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037837">
        <property type="entry name" value="PH_Kindlin/fermitin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16160">
        <property type="entry name" value="FERMITIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16160:SF13">
        <property type="entry name" value="FERMITIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18124">
        <property type="entry name" value="Kindlin_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="403"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="228"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="228"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0805261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="708" mass="80906" checksum="823D484A8B0D2ED3" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B762</accession>
    <name>A0A5N4B762_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_02368</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0805398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B762"/>
    <dbReference type="InParanoid" id="A0A5N4B762"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0805398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="135" mass="15490" checksum="B451A6CEAEF4E71F" modified="2020-02-26" version="1">MKRNSQIAIRQPEATSLGRATSFNAHCWPILWKNLRGDILEKIFKSLPAIYINGDETSLPQFQSLQKVLAVKRPETSKGRLSLQKGHVSNNVFGFINAALGNNPRFLSSLEKSFWHMLIMDQKHVWDWLINSGWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B782</accession>
    <name>A0A5N4B782_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">DNA polymerase alpha subunit B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PPYR_02180</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the DNA polymerase alpha subunit B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0805210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B782"/>
    <dbReference type="FunCoup" id="A0A5N4B782">
        <property type="interactions" value="1165"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4B782"/>
    <dbReference type="OrthoDB" id="336885at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.530">
        <property type="entry name" value="DNA polymerase alpha-primase, subunit B, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007185">
        <property type="entry name" value="DNA_pol_a/d/e_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043034">
        <property type="entry name" value="DNA_pol_alpha_B_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016722">
        <property type="entry name" value="DNA_pol_alpha_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054300">
        <property type="entry name" value="OB_DPOA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013627">
        <property type="entry name" value="Pol_alpha_B_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23061">
        <property type="entry name" value="DNA POLYMERASE 2 ALPHA 70 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23061:SF12">
        <property type="entry name" value="DNA POLYMERASE ALPHA SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04042">
        <property type="entry name" value="DNA_pol_E_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22062">
        <property type="entry name" value="OB_DPOA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08418">
        <property type="entry name" value="Pol_alpha_B_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018300">
        <property type="entry name" value="DNA_pol_alph_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA polymerase alpha subunit B N-terminal" evidence="9">
        <location>
            <begin position="14"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="DNA polymerase alpha subunit B OB" evidence="10">
        <location>
            <begin position="220"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="DNA polymerase alpha/delta/epsilon subunit B" evidence="8">
        <location>
            <begin position="341"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="78"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR018300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF22062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0805210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="591" mass="64850" checksum="6F4073366D4AA6BB" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B7M5</accession>
    <name>A0A5N4B7M5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ornithine decarboxylase</fullName>
            <ecNumber evidence="7">4.1.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PPYR_02546</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-ornithine + H(+) = putrescine + CO2</text>
            <dbReference type="Rhea" id="RHEA:22964"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:326268"/>
            <dbReference type="EC" id="4.1.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amine and polyamine biosynthesis; putrescine biosynthesis via L-ornithine pathway; putrescine from L-ornithine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer. Only the dimer is catalytically active, as the active sites are constructed of residues from both monomers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Orn/Lys/Arg decarboxylase class-II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.17" evidence="7"/>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0805576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B7M5"/>
    <dbReference type="InParanoid" id="A0A5N4B7M5"/>
    <dbReference type="OrthoDB" id="5034579at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004586">
        <property type="term" value="F:ornithine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033387">
        <property type="term" value="P:putrescine biosynthetic process from arginine, via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00622">
        <property type="entry name" value="PLPDE_III_ODC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.10:FF:000005">
        <property type="entry name" value="Ornithine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="entry name" value="Alanine racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="entry name" value="Lyase, Ornithine Decarboxylase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022657">
        <property type="entry name" value="De-COase2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022653">
        <property type="entry name" value="De-COase2_pyr-phos_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000183">
        <property type="entry name" value="Orn/DAP/Arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002433">
        <property type="entry name" value="Orn_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11482">
        <property type="entry name" value="ARGININE/DIAMINOPIMELATE/ORNITHINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11482:SF6">
        <property type="entry name" value="ORNITHINE DECARBOXYLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01179">
        <property type="entry name" value="ODADCRBXLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01182">
        <property type="entry name" value="ORNDCRBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="Alanine racemase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="PLP-binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00878">
        <property type="entry name" value="ODR_DC_2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00879">
        <property type="entry name" value="ODR_DC_2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="3 11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orn/DAP/Arg decarboxylase 2 N-terminal" evidence="12">
        <location>
            <begin position="40"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="337"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="11">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR600183-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAB0805576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="432" mass="49024" checksum="138C7A6F02E9ADDA" modified="2020-02-26" version="1">MNSESESIEVYNNDTTVNKIIAEKVRHLHHIEPFFICDIREVLRKCSLWAELFPRVKPFYAVKANSSRLVLKVMADFGINFDCASKYEIDLALSLGIPPKRIIYAHSIKTSSYIKYASDADIKLMTFDNEEELRKMKRLCPDVQAIIRIKYDAKNAFLKLGEKFGCNVENEADELINLAQSLCVNLVGVSFHIGVGCTDLPTFYNAIKSARIVFDIAKRYGYDLRILDIGGGFPGADDVLLKQIALTVNNALDMYFSDQSIQIIAEPGTVLVDSAFTLACNVISRKFKSNKWIYYINDGLHGSFHKGLIVGSPFTMYPLKIPSHKELYSSTIFGVTCGAKDKLIENLTLPSLEIDDWLILKNMGAYSLGLHTSMNGFFVPRMFYVTDFNNLTRYGLSEFNYKFTKTILKEATDDRTNLNEEFRVTFCLDFIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1K3N6</accession>
    <name>A0A1Y1K3N6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcription factor BTF3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PPYR_11901</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the NAC-beta family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01097404">
        <property type="protein sequence ID" value="JAV54224.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01097403">
        <property type="protein sequence ID" value="JAV54225.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0795062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1K3N6"/>
    <dbReference type="FunCoup" id="A0A1Y1K3N6">
        <property type="interactions" value="1953"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1K3N6"/>
    <dbReference type="OrthoDB" id="8033832at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22055">
        <property type="entry name" value="NAC_BTF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.30:FF:000001">
        <property type="entry name" value="Transcription factor BTF3 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.30">
        <property type="entry name" value="Nascent polypeptide-associated complex domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039370">
        <property type="entry name" value="BTF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038187">
        <property type="entry name" value="NAC_A/B_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002715">
        <property type="entry name" value="Nas_poly-pep-assoc_cplx_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10351">
        <property type="entry name" value="TRANSCRIPTION FACTOR BTF3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01849">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01407">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51151">
        <property type="entry name" value="NAC_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAC-A/B" evidence="4">
        <location>
            <begin position="33"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="JAV54225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0795062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="166" mass="18032" checksum="1404BDA725E20DA7" modified="2017-08-30" version="1">MNTEKLKKLQAQVRIGGKGTPRRKKKVVHSTQATDDKKLQSSLKKLAVNTIPGIEEVNMIKDDGTVIHFNNPKAQASLAANTFAITGHGETKQITEMLPGILSQLGPEGLNQLKRLANTVANAGVGKILPEDEEDVPDLVENFDEASKAEVGKKKEDGKPKDKKQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1K456</accession>
    <name>A0A1Y1K456_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Amine oxidase</fullName>
            <ecNumber evidence="4">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_06741</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the flavin monoamine oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="4"/>
    <dbReference type="EMBL" id="GEZM01098914">
        <property type="protein sequence ID" value="JAV53647.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0798861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1K456"/>
    <dbReference type="InParanoid" id="A0A1Y1K456"/>
    <dbReference type="OrthoDB" id="5046242at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046592">
        <property type="term" value="F:polyamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008131">
        <property type="term" value="F:primary methylamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001613">
        <property type="entry name" value="Flavin_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050281">
        <property type="entry name" value="Flavin_monoamine_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742:SF398">
        <property type="entry name" value="AMINE OXIDASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742">
        <property type="entry name" value="FLAVIN MONOAMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00757">
        <property type="entry name" value="AMINEOXDASEF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="5">
        <location>
            <begin position="20"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="41"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR601613-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="JAV53647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0798861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="469" mass="52730" checksum="74A0BAE0D79529E3" modified="2017-08-30" version="1">MTNRMMPSCGPRVVIVGAGVAGIAAASRLIENGFANCIILEAEDRVGGRICTRRLGDGVVDLGAQYCRKDSIVYHLVKDFDLLEVRNVSTHVYHSQNGRLEDSFVNKLLDKVSDLYHGGPVQNVEWKQYLEERFDDEIVDLFHDERQRLLARDNMDFVKKQVLLCTGSICLNGVYGATSGEFPPDFRCVWKSHGYQALLDILMKKHLKTKSALQYEQKVILNSEVTKIEWGEEDGAKVICANGLYYLADYVIVTVPLGALKRQHSTLFSPALPKTKQKVIELLGFGSILKVCFHFSTKWWSDNDFAFAWGEEDLKTALIKSEHPWMTNCMGFYLVPNNPNVLMAWFVGNYISTLESISDDVLLDGAHMVLQRFLGRTFQNITKPIKLERNRWCTNPHFGGMVSYETLQSKRHGLTGETLAESVDSKVGIPQLLFGGEATMKVGYGSVNGAVMSGFREADRIINYCRGNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1K689</accession>
    <name>A0A1Y1K689_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PPYR_03477</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="EMBL" id="GEZM01094306">
        <property type="protein sequence ID" value="JAV55720.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1K689"/>
    <dbReference type="InParanoid" id="A0A1Y1K689"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02674">
        <property type="entry name" value="Peptidase_C19R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000083">
        <property type="entry name" value="Uncharacterized protein, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF23">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE USP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="4">
        <location>
            <begin position="435"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="79"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="394"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="79"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="93"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="394"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="JAV55720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0791677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="777" mass="87660" checksum="F2151A086CB96184" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1K6H4</accession>
    <name>A0A1Y1K6H4_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PPYR_01939</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat G protein beta family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01091257">
        <property type="protein sequence ID" value="JAV56983.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1K6H4"/>
    <dbReference type="FunCoup" id="A0A1Y1K6H4">
        <property type="interactions" value="477"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1K6H4"/>
    <dbReference type="OrthoDB" id="10255630at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Guanine nucleotide-binding protein beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016346">
        <property type="entry name" value="G-protein_beta_1-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001632">
        <property type="entry name" value="WD40_G-protein_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19850">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN BETA G PROTEIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25391">
        <property type="entry name" value="WD40_Gbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002394">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00319">
        <property type="entry name" value="GPROTEINB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="62"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="150"/>
            <end position="191"/>
        </location>
    </feature>
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        <location>
            <begin position="192"/>
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        </location>
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        <location>
            <begin position="236"/>
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        </location>
    </feature>
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            <begin position="287"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="322"/>
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        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="15"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="JAV56983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0804969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="354" mass="38982" checksum="ACEA3C218B1E9543" modified="2017-08-30" version="1">MSRDVSVKISPVETIESLTKEAEHLKIKLEDERQKLNDVTLAAVADRLEIINYMNVKPRRTLKGHQAKVLCSDWSPDKRHIVSSSQDGKMIIWDAFTTNKEHAVTMPTTWVMACAYAPSGNLVACGGLDNKVTVYPLSLDEDVTLKKKTVGTHTSYTSCCTFPNSDQQILTGSGDSTCALWDVESGQLLQSFHGHAADVMSIDLAPSEIGNTFVSGSCDKMVYLWDMRTGHCVQSFEGHESDVNSVKFHPSGDAIATGSDDATCRLFDLRADREVAVYNKESIIFGINAVDFSVSGRLLFAGYNDYTVNVWDTLKCVRVCLLYGHENRVSCLQVSPDGTALSSGSWDCTLRVWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1K927</accession>
    <name>A0A1Y1K927_PHOPY</name>
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        <recommendedName>
            <fullName evidence="5">Spaetzle domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_13576</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01095849">
        <property type="protein sequence ID" value="JAV55297.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1K927"/>
    <dbReference type="InParanoid" id="A0A1Y1K927"/>
    <dbReference type="OrthoDB" id="6359065at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005121">
        <property type="term" value="F:Toll binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021556">
        <property type="term" value="P:central nervous system formation"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Protein spaetzle"/>
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    </dbReference>
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        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
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        <property type="entry name" value="Spaetzle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052444">
        <property type="entry name" value="Spz/Toll_ligand-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23199">
        <property type="entry name" value="NEUROTROPHIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23199:SF12">
        <property type="entry name" value="NEUROTROPHIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
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    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033289544" description="Spaetzle domain-containing protein" evidence="4">
        <location>
            <begin position="21"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Spaetzle" evidence="5">
        <location>
            <begin position="128"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="JAV55297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0793956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="226" mass="25598" checksum="D26B927F2C109389" modified="2017-08-30" version="1">MADLMLVVFLLLNVILVTKSWPGRWPATKRETQQNTTSTTTDDGIVFPDVYSTMDRYLPPAEADFSASGKGQNCVAGVCNEAKDYPYNHIKDVLNKIKTYNKLFGFLEGTVVTLPNRFKPGVDEEDETLCPVITHTVYPKTIKNENDTERYIINIDEHKQGLVFETCVEKAKCKFYNIFPAIYTSQCSQRYARRRLVALEEDGKPATDTFVVPSCCVCTVKIKKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1K9U3</accession>
    <name>A0A1Y1K9U3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">CLIP domain-containing serine protease</fullName>
            <ecNumber evidence="9">3.4.21.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PPYR_06346</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The clip domain consists of 35-55 residues which are 'knitted' together usually by 3 conserved disulfide bonds forming a clip-like compact structure.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 10">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="9"/>
    <dbReference type="EMBL" id="GEZM01092820">
        <property type="protein sequence ID" value="JAV56445.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000004">
        <property type="protein sequence ID" value="KAB0800606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1K9U3"/>
    <dbReference type="FunCoup" id="A0A1Y1K9U3">
        <property type="interactions" value="14"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1K9U3"/>
    <dbReference type="OrthoDB" id="9028152at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035008">
        <property type="term" value="P:positive regulation of melanization defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1640.30:FF:000001">
        <property type="entry name" value="Serine protease 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000028">
        <property type="entry name" value="Serine protease easter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000084">
        <property type="entry name" value="Serine protease easter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022700">
        <property type="entry name" value="CLIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038565">
        <property type="entry name" value="CLIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051487">
        <property type="entry name" value="Ser/Thr_Proteases_Immune/Dev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24256">
        <property type="entry name" value="TRYPTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12032">
        <property type="entry name" value="CLIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00680">
        <property type="entry name" value="CLIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51888">
        <property type="entry name" value="CLIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 9" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 9" id="KW-0720">Serine protease</keyword>
    <keyword evidence="2 10" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033827650" description="CLIP domain-containing serine protease" evidence="10">
        <location>
            <begin position="30"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="Clip" evidence="12">
        <location>
            <begin position="30"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="11">
        <location>
            <begin position="115"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="JAV56445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAB0800606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="367" mass="40589" checksum="92F58AF052C988EB" modified="2017-08-30" version="1">MTKSQISCGNFFNYFTIIVLLGKIHGGSAQCTTPNEKRGNCIPIRECPALLGILEKGVINPDEIQLLQQSQCGYIRNQPKVCCEVETSQPVNPDVQTSELLPAPGVCGKILAPRIVGGKVARLDEFQWMALIEYSKPTGRGFHCGGALISDRYVLTAAHCIKNIPRGWRLVSVRLGEHNLQSDIDCEEYCADPPQNVAVEESIPHELYDPKSIHRYNDVAVLRLQRPVAFTDYIFPICLPSTQNTAYAGLTMTVAGWGRTENRSQSVSKMKLDVPVRPQQECISTYQKAKVELREGQICAGGVKGKDSCTGDSGGPLMYVNQTEFDQIYFITGIVSFGPSNCGLQDWPGVYTKVVDYIPWIINKLKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1KBP9</accession>
    <name>A0A1Y1KBP9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Annexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PPYR_14592</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="domain">
        <text evidence="6">A pair of annexin repeats may form one binding site for calcium and phospholipid.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the annexin family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01093638">
        <property type="protein sequence ID" value="JAV56207.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1KBP9"/>
    <dbReference type="FunCoup" id="A0A1Y1KBP9">
        <property type="interactions" value="72"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1KBP9"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012506">
        <property type="term" value="C:vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.10:FF:000001">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.10:FF:000002">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.10:FF:000004">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.10:FF:000010">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.10">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001464">
        <property type="entry name" value="Annexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018502">
        <property type="entry name" value="Annexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018252">
        <property type="entry name" value="Annexin_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037104">
        <property type="entry name" value="Annexin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502">
        <property type="entry name" value="ANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502:SF177">
        <property type="entry name" value="ANNEXIN B10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00191">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00196">
        <property type="entry name" value="ANNEXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00335">
        <property type="entry name" value="ANX"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47874">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00223">
        <property type="entry name" value="ANNEXIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51897">
        <property type="entry name" value="ANNEXIN_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0041">Annexin</keyword>
    <keyword evidence="3 6" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 6" id="KW-0111">Calcium/phospholipid-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="JAV56207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0792633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="314" mass="35612" checksum="BAB10D495F870346" modified="2017-08-30" version="1">MRTPTVYPREGFSVVEDGETLRGAMKGFGTDEEAVIDIICTRSNWQRQQIAAFFEEQLGRDLIDDLKSELGGNFEDVIVALVRPPTEYLCKHLHRAMKGAGTDEDTLIEILCTRNNDEIREIVDTYEQMYDRPLAEQMCSETSGDLRRLLTFIVTCTRDDSNEVDCERAREQAEELYAAGEGRLGTEESSFSKILGHENFDQLRQIFEEYKNVSGNTIEQALRHEVDGDYLKALLAVVECVQSPPAYFAKRLYGAMKGAGTDDETLIRIIVSRSEIDLGSIKEEFERIYDKTLESMVANETSGDYKRALLALLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1KF46</accession>
    <name>A0A1Y1KF46_PHOPY</name>
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        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PPYR_06412</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GEZM01085211">
        <property type="protein sequence ID" value="JAV60116.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
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    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR14212">
        <property type="entry name" value="U4/U6-ASSOCIATED RNA SPLICING FACTOR-RELATED"/>
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    </dbReference>
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        <property type="entry name" value="U4_U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP3"/>
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        </location>
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        </location>
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        </location>
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            <end position="123"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="JAV60122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0800673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="630" mass="72568" checksum="7C4E470ED77A2347" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1KGW2</accession>
    <name>A0A1Y1KGW2_PHOPY</name>
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            <fullName evidence="1">Kelch-like protein diablo</fullName>
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        <name evidence="7" type="ORF">PPYR_11260</name>
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    <organism evidence="6">
        <name type="scientific">Photinus pyralis</name>
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    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
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                <person name="Al-Wathiqui N."/>
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                <person name="Weng J.K."/>
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            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. May have a role in synapse differentiation and growth.</text>
    </comment>
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        <property type="protein sequence ID" value="JAV59828.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0794421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="UniPathway" id="UPA00143"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
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    </dbReference>
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    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632:SF3">
        <property type="entry name" value="KELCH-LIKE PROTEIN 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632">
        <property type="entry name" value="LD33804P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00043912"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="JAV59828.1"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
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    </evidence>
    <sequence length="612" mass="70503" checksum="1BB595A8A9C2D1A5" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1KI45</accession>
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        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
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        <name evidence="4" type="ORF">PPYR_01984</name>
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    <organism evidence="3">
        <name type="scientific">Photinus pyralis</name>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
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            <begin position="406"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="620"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="710"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="623"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="710"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="757"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="784"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="816"/>
            <end position="838"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="JAV67772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0798586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="846" mass="96635" checksum="6E566AD9C279E965" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1L4E6</accession>
    <name>A0A1Y1L4E6_PHOPY</name>
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        <recommendedName>
            <fullName evidence="4">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PPYR_09563</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01066900">
        <property type="protein sequence ID" value="JAV67661.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1L4E6"/>
    <dbReference type="FunCoup" id="A0A1Y1L4E6">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1L4E6"/>
    <dbReference type="OrthoDB" id="8950604at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21407:SF1">
        <property type="entry name" value="RE43931P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21407">
        <property type="entry name" value="RE43931P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033750475" description="C-type lectin domain-containing protein" evidence="3">
        <location>
            <begin position="18"/>
            <end position="217"/>
        </location>
    </feature>
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        <location>
            <begin position="46"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="139"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="JAV67661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0798570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="217" mass="24648" checksum="37828EE7EB7C1F39" modified="2017-08-30" version="1">MLRELSLLIIGAGMVLAQRRLALPDPRSCANRVRHATYRDARGVAHSYFFSWEHGPTRSLEVDWLDARNICRRHCMDAVSLETPQENEFVKQRIARGNVRYIWTSGRKCNFAGCDRSDLQPANIFGWFWSGSGVKIGPTTQRNSGDWSHTGGYGQPQPDNREAAQGNDESCLSILNNFYRDGIKWHDVACHHVKPFVCEDSEELLNFVASRNPGIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LG21</accession>
    <name>A0A1Y1LG21_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Mediator of RNA polymerase II transcription subunit 18</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">Mediator complex subunit 18</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">MED18</name>
        <name evidence="12" type="ORF">PPYR_04084</name>
        <name evidence="13" type="ORF">PPYR_04132</name>
        <name evidence="14" type="ORF">PPYR_04854</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12 15" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 10">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the Mediator complex subunit 18 family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01058189">
        <property type="protein sequence ID" value="JAV71808.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0801898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0801946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1LG21"/>
    <dbReference type="FunCoup" id="A0A1Y1LG21">
        <property type="interactions" value="1133"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1LG21"/>
    <dbReference type="OrthoDB" id="10018982at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.320.10:FF:000001">
        <property type="entry name" value="Mediator of RNA polymerase II transcription subunit 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.320.10">
        <property type="entry name" value="Hypothetical Protein Pfu-838710-001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019095">
        <property type="entry name" value="Mediator_Med18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13321:SF2">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13321">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION, SUBUNIT 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09637">
        <property type="entry name" value="Med18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0010">Activator</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 10" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="JAV71808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAB0801898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAB0801946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAB0802668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="223" mass="24926" checksum="B43E1E5B5BB259BE" modified="2017-08-30" version="1">MAVIGSATDTLNTALKSNIVPDQEYLLQGSVLDQYVEVLLHRLRGLCDNVDSGPESFHDHELCFTLRATSGPGSAMVLPLRVRRALDVPEAPWQLRYVGQHELGDKNRPTVVRSSIDMACSSTIVEFLTELGCRMDFEYISRGYMFRKGRMKITVSKVFKMGGLTNKPGESVEPISQSYLVELSVLAPSGQDAIAEDMRVFAEQLKPLVHLEKIDYKRLAHLQ</sequence>
</entry>
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    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
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        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
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        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
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        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
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        </location>
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        </location>
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            <begin position="72"/>
            <end position="86"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51053"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="JAV73402.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAB0804513.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="324" mass="36667" checksum="32FA2D39107D832C" modified="2017-08-30" version="1">MWFESQNCAMMGLQGTTGKRKLEAAVAPGELSPAKNGRWEAQDCIARLQAVAVPSDTWRSPTPSLTATLLTDDFEDDDDFEDELSDDDRIPGIPEPARYPQYPRYPPDYWQYYQPPQQQTIRCEENGKSYLELGAAPPQRTRCCDGRTRWCHIPCYRQRRLAVLNLSMCKLARYRQCSDPSLRRSVLICNTLRRLEREMETDPPEPSYSNLPELSPPSRISPVIPEPNYEQTLREMTCSSGRATPFPSTLPDSDSGIGDDDMTKPINWGSVLSLTAQTDLEPLNNNELYAELGLSSDMTQEWKEPSTSRSDDWDGFMHVLVGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LQ46</accession>
    <name>A0A1Y1LQ46_PHOPY</name>
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        <recommendedName>
            <fullName evidence="8">TGF-beta family profile domain-containing protein</fullName>
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    </protein>
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        <name evidence="10" type="ORF">PPYR_05244</name>
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        <name type="scientific">Photinus pyralis</name>
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    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
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                <person name="Al-Wathiqui N."/>
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            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
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        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the TGF-beta family.</text>
    </comment>
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        <property type="protein sequence ID" value="JAV75782.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KAB0800890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Cystine-knot cytokines"/>
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    </dbReference>
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        <property type="entry name" value="Cystine-knot_cytokine"/>
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        <property type="entry name" value="TGF-b_propeptide"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR017948">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11848:SF119">
        <property type="entry name" value="TGF-BETA FAMILY PROFILE DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF00688">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
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        </location>
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        <location>
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        </source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="331" mass="37842" checksum="86922CB0313CC28B" modified="2017-08-30" version="1">MGGHFWALIATWTFLCSIRVVLADESFEQELGLSAFPDVTKVNVSQDEYTRMMRTYLHTLRESMDNHSVPELQTFDAETITWHPKKKYVTRLGFSGVSMSSEMEIEQADLRILVSSFVDAPSPTIKIYQILSARRRRLLDEKVVYLSSTASKWCEFDVTSGVDSWLKGNRNLGIELQCAQCNNSVLQPLQATLSILVYTTPKRVRRSSPYNYEEGGRTDCINGEKRQKCCRHTMKVTFKDLKVPQISSIIQPKSYEAGFCKGRCPYNYNHATNHSRIQSLVHKLDRKAVPRVCCAPSKLAPLDVLRVDPYDYTKLNVEKWDNMKVLECACS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="7">alpha-1,2-Mannosidase</fullName>
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        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
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                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
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                <person name="Bessho-Uehara M."/>
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                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
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            <dbReference type="DOI" id="10.1038/srep38556"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">1611_PpyrPB1</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">1611_PpyrPB1</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GEZM01023896">
        <property type="protein sequence ID" value="JAV88158.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1MSS3"/>
    <dbReference type="FunCoup" id="A0A1Y1MSS3">
        <property type="interactions" value="996"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1MSS3"/>
    <dbReference type="OrthoDB" id="419183at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000138">
        <property type="entry name" value="CXXC-type zinc finger protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022056">
        <property type="entry name" value="CpG-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037869">
        <property type="entry name" value="Spp1/CFP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002857">
        <property type="entry name" value="Znf_CXXC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46174">
        <property type="entry name" value="CXXC-TYPE ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46174:SF1">
        <property type="entry name" value="CXXC-TYPE ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12269">
        <property type="entry name" value="CpG_bind_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02008">
        <property type="entry name" value="zf-CXXC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51058">
        <property type="entry name" value="ZF_CXXC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="15">
        <location>
            <begin position="34"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="CXXC-type" evidence="16">
        <location>
            <begin position="117"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="253"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="103"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00081451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="JAV88158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAB0791598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="496" mass="58011" checksum="A31DB3B578239C6B" modified="2017-08-30" version="1">MSRKRDISREEIAKQFLLPERQSKIDTLLRQDGQAYCICRSSDSSRFMIACDACEEWYHGDCIGISEREAKHIKQYFCVRCIEEDSTLQTRWRTKRDDTGNKDEYRVRKRRERGETKSDKKNKKCGDCMGCYRTDDCGRCDVCLRKYKHGGGRQKERCKQRICVNFGGTRGRRRRRDSGSDIEQPPNAHLMTDYPRQCYGPGCVNSARYGSKYCSDTCGVRLATNRIYQVLPQRIQEWALSPCVAEEKNIKALDQVRKNQLEVRQILQELDKRHKELDYIVERAKNAVIDSNLDQDNDEEADLSTYCLTCGHEIHSRTAIKHMEKCFNKYESQASFGSKFKTRIEGNNMFCDFYNANNRTYCKRLRVLCPEHCKDPKVGDNEVCGCPLVTNVFDLTGEFCRAPKKSCGKHFVWEKLRRAEIDLERVRQWLKMDELLEKERHIRQSMASRAGVLALMLHSTYNHEVMEEITKASQQDQAAVQLELAKRFKKREKPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1MWE9</accession>
    <name>A0A1Y1MWE9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Glutamate decarboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PPYR_06922</name>
        <name evidence="11" type="ORF">PPYR_06948</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the group II decarboxylase family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01020016">
        <property type="protein sequence ID" value="JAV89458.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1MWE9"/>
    <dbReference type="FunCoup" id="A0A1Y1MWE9">
        <property type="interactions" value="178"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1MWE9"/>
    <dbReference type="OrthoDB" id="392571at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06450">
        <property type="entry name" value="DOPA_deC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000016">
        <property type="entry name" value="Glutamate decarboxylase like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45677:SF12">
        <property type="entry name" value="BLACK, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45677">
        <property type="entry name" value="GLUTAMATE DECARBOXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="6 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="JAV89458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0799042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0799068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="536" mass="60616" checksum="051B2CE422C6D584" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1N076</accession>
    <name>A0A1Y1N076_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TMEM248/TMEM219 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PPYR_03542</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
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                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
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            <dbReference type="DOI" id="10.1038/srep38556"/>
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                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
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                <person name="Sander Lower S.E."/>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
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                <person name="Shigenobu S."/>
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        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
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            <authorList>
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                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLX4 family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01004682">
        <property type="protein sequence ID" value="JAV96341.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
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        <property type="protein sequence ID" value="KAB0803963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A1Y1NEU8"/>
    <dbReference type="InParanoid" id="A0A1Y1NEU8"/>
    <dbReference type="OrthoDB" id="5576441at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033557">
        <property type="term" value="C:Slx1-Slx4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22999">
        <property type="entry name" value="SAP_SLX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018574">
        <property type="entry name" value="Structure-sp_endonuc_su_Slx4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21541">
        <property type="entry name" value="BTB POZ DOMAIN CONTAINING 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21541:SF3">
        <property type="entry name" value="STRUCTURE-SPECIFIC ENDONUCLEASE SUBUNIT SLX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09494">
        <property type="entry name" value="Slx4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="46"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="294"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="56"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="334"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="353"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="JAV96341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0803963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="692" mass="78739" checksum="04BD034DFD1C5817" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1NFN6</accession>
    <name>A0A1Y1NFN6_PHOPY</name>
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        <recommendedName>
            <fullName evidence="7">inositol-1,4-bisphosphate 1-phosphatase</fullName>
            <ecNumber evidence="7">3.1.3.57</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PPYR_03938</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
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            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>1D-myo-inositol 1,3,4-trisphosphate + H2O = 1D-myo-inositol 3,4-bisphosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:70319"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58414"/>
            <dbReference type="ChEBI" id="CHEBI:83241"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:70320"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>1D-myo-inositol 1,4-bisphosphate + H2O = 1D-myo-inositol 4-phosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15553"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58282"/>
            <dbReference type="ChEBI" id="CHEBI:58469"/>
            <dbReference type="EC" id="3.1.3.57"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:15554"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.57" evidence="7"/>
    <dbReference type="EMBL" id="GEZM01003683">
        <property type="protein sequence ID" value="JAV96631.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0801752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1NFN6"/>
    <dbReference type="FunCoup" id="A0A1Y1NFN6">
        <property type="interactions" value="116"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1NFN6"/>
    <dbReference type="OrthoDB" id="9977309at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004441">
        <property type="term" value="F:inositol-1,4-bisphosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.460.10">
        <property type="entry name" value="Inositol Polyphosphate 1-phosphatase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050725">
        <property type="entry name" value="CysQ/Inositol_MonoPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020583">
        <property type="entry name" value="Inositol_monoP_metal-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044897">
        <property type="entry name" value="INPP1_dom_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43028">
        <property type="entry name" value="3'(2'),5'-BISPHOSPHATE NUCLEOTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43028:SF3">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE 1-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0452">Lithium</keyword>
    <keyword evidence="4 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
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    <feature type="binding site" evidence="8">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
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    <feature type="binding site" evidence="8">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
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            <note>catalytic</note>
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        <location>
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        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR600760-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="JAV96631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0801752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="369" mass="40455" checksum="B407104FA3D40B94" modified="2017-08-30" version="1">MSLLEALINVSEKAANIARLCRQEQHLFELLVEEKSSSESNPRFVQDFKTLADVLIQETVKYDIGLQFPELKESIKGEEDNVFCNTIGEKIVVQIQPDVTSTANLLQTVLNGADVAARLLAEEVHRNISLKEIDVYLDNIPKDVALDYGQLGIWIDPIDSTAEYIHAKEVVGVSGICVNGLKCVTVLIGVFDKLTGIPVMGVVNQPFFKPVDNRWSGRCYWGLTTPSITVSSLTVNHSIDNQSNVICISTSEDGNIKRKLQGAGFNLIEAAGAGYKILTVITRQAAAYVLSKNTTFKWDTCGPQAILKSIGGNIVQYNAVNGNHCKPIEYPTHSGNGDVNKIKLYCNDGGIIAFYNEEVLTKIMDALCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1NGE4</accession>
    <name>A0A1Y1NGE4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">2Fe-2S ferredoxin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PPYR_04693</name>
        <name evidence="17" type="ORF">PPYR_10416</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17 19" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">1611_PpyrPB1</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">1611_PpyrPB1</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Required for ecdysteroidogenesis in the prothoracic gland which is necessary for larval to pupal transition.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the adrenodoxin/putidaredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01003731">
        <property type="protein sequence ID" value="JAV96608.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1NGE4"/>
    <dbReference type="FunCoup" id="A0A1Y1NGE4">
        <property type="interactions" value="667"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1NGE4"/>
    <dbReference type="OrthoDB" id="268593at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140647">
        <property type="term" value="P:P450-containing electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045998">
        <property type="term" value="P:positive regulation of ecdysteroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006694">
        <property type="term" value="P:steroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000013">
        <property type="entry name" value="Adrenodoxin, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001055">
        <property type="entry name" value="Adrenodoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018298">
        <property type="entry name" value="Adrenodoxin_Fe-S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23426:SF76">
        <property type="entry name" value="ADRENODOXIN-LIKE PROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23426">
        <property type="entry name" value="FERREDOXIN/ADRENODOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00355">
        <property type="entry name" value="ADRENODOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00814">
        <property type="entry name" value="ADX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="12" id="KW-0755">Steroidogenesis</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="15">
        <location>
            <begin position="40"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00054507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="JAV96608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAB0796355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAB0802507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="151" mass="16894" checksum="118951004D164A02" modified="2017-08-30" version="1">MALRCFMRNLSILPKRMLRPNNVNCRIFSTTSPLTNKKQIEVTFLKADGERLKVKANVGDTLLDVVVNNNVDLEGFGACEGTLTCSTCHLIFTQKDYDQLPDKPTDEELDMLDLAYELSDTSRLGCQIILSESMEGLEVKVPASIHDVRAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1NHH1</accession>
    <name>A0A1Y1NHH1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Insulin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PPYR_08026</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Heterodimer of a B chain and an A chain linked by two disulfide bonds.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the insulin family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01003006">
        <property type="protein sequence ID" value="JAV96988.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0800146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1NHH1"/>
    <dbReference type="InParanoid" id="A0A1Y1NHH1"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005179">
        <property type="term" value="F:hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04366">
        <property type="entry name" value="IlGF_insulin_bombyxin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.100.10">
        <property type="entry name" value="Insulin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022352">
        <property type="entry name" value="Ins/IGF/rlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016179">
        <property type="entry name" value="Insulin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036438">
        <property type="entry name" value="Insulin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022353">
        <property type="entry name" value="Insulin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13647:SF4">
        <property type="entry name" value="INSULIN-LIKE PEPTIDE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13647">
        <property type="entry name" value="INSULIN-LIKE PEPTIDE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00049">
        <property type="entry name" value="Insulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00276">
        <property type="entry name" value="INSULINFAMLY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00078">
        <property type="entry name" value="IlGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56994">
        <property type="entry name" value="Insulin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00262">
        <property type="entry name" value="INSULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="Insulin-like" evidence="8">
        <location>
            <begin position="38"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="JAV96988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0800146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="105" mass="11821" checksum="9FB6248A128BB168" modified="2017-08-30" version="1">MGLWDVLYALAVYLLATFTVSALTSPEDKLQMMQAKNATYCGSALADALSLVCRGKYNTPVTNERDRRSISPNNRKKRYIITKGVYDECCKNACSYAVLKSYCWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1NK74</accession>
    <name>A0A1Y1NK74_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PPYR_14304</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01005558">
        <property type="protein sequence ID" value="JAV96097.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1NK74"/>
    <dbReference type="InParanoid" id="A0A1Y1NK74"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050688">
        <property type="entry name" value="Zinc_finger/UBP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24403:SF67">
        <property type="entry name" value="FI01116P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24403">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="97"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="125"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="181"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="237"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="264"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="JAV96097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0792345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="354" mass="41339" checksum="E9A771D2E408C9FA" modified="2017-08-30" version="1">MSTVTISGFVEVEPKREEEEESATVNGDVLIKHEVATEDNGSASGIKSELKVKRETQQQEGEVASYFIKPLLLYDECMEDKSNVLNVGVNESLHTDFRCFQCDYTSSMKKNLRKHILRHITPRNLKCDHCNYLTNDKDNLRQHVRTHNAKKEYTCSICSYATNAKHSYSRHLLKHNALKDLKCDRCAYATHSKGNLKQHLLTHRNEKRFKCDQCTFETHVEMYLKRHALNHKLTTDFKCSYCPYATNVKKNFKKHFSKHTRENLKCEHCDYTTSVRENLKQHLLTHRALKDFECVHCEFRTNTLKYLKQHLATHKNSKEFKCFGCEYKTSVKGRLKRHLLSHRISAVNGVVPIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N3ZY44</accession>
    <name>A0A5N3ZY44_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phenoloxidase-activating factor 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Prophenoloxidase-activating factor II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PPYR_15727</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01002117">
        <property type="protein sequence ID" value="KAB0789981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N3ZY44"/>
    <dbReference type="InParanoid" id="A0A5N3ZY44"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000038">
        <property type="entry name" value="Serine protease"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041515">
        <property type="entry name" value="PPAF-2-like_Clip"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24258:SF129">
        <property type="entry name" value="LP15124P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24258">
        <property type="entry name" value="SERINE PROTEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18322">
        <property type="entry name" value="CLIP_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024352370" description="Phenoloxidase-activating factor 2" evidence="6">
        <location>
            <begin position="22"/>
            <end position="1208"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="7">
        <location>
            <begin position="134"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="7">
        <location>
            <begin position="530"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="7">
        <location>
            <begin position="947"/>
            <end position="1197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00068096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00076468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0789981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1208" mass="132798" checksum="402C011CFAC9F03C" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-06-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N3ZY86</accession>
    <name>A0A5N3ZY86_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_15676</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01002053">
        <property type="protein sequence ID" value="KAB0790024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N3ZY86"/>
    <dbReference type="InParanoid" id="A0A5N3ZY86"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0790024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="66" mass="7757" checksum="F35846438FDA0860" modified="2020-02-26" version="1">MIKANLTRFKNYIESIKDLGYDENTLVQLKLRLVKIEPCLEKFNDLEAEIELSEGGEVDEDERYSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N3ZYY6</accession>
    <name>A0A5N3ZYY6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Lipid-binding serum glycoprotein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_15383</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01001566">
        <property type="protein sequence ID" value="KAB0790283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N3ZYY6"/>
    <dbReference type="InParanoid" id="A0A5N3ZYY6"/>
    <dbReference type="OrthoDB" id="8196554at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.30">
        <property type="entry name" value="Haemolymph juvenile hormone binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010562">
        <property type="entry name" value="Haemolymph_juvenile_hormone-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038606">
        <property type="entry name" value="To_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008:SF18">
        <property type="entry name" value="BCDNA.GH05536-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008">
        <property type="entry name" value="PROTEIN TAKEOUT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06585">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00700">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024394625" description="Lipid-binding serum glycoprotein N-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0790283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="245" mass="27350" checksum="BFE18FE7AB1AEDDA" modified="2020-02-26" version="1">MNYSTHFLLLVHVAVAASYSNILSQLQVCKRSDPNLNGCLRTAIQAALPLLKNGVPEISFPSMNPIKIEMVYINAEPPMDFDQVYSNIELHGHADSVITDVSTRIDEKNVIMAIKGECNTGTLSMGLEYKDAIVFGFDLSGKGRMEQIHHDYHFLIYIEGELKPKAKHLSIRNVTVDVDLKDFSITVDLYGNQQLSKTVSKVFTDNSALLYGAVRKEVEEIYGAAYGNLVKRLFAKIPIDELLPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N3ZYZ4</accession>
    <name>A0A5N3ZYZ4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein inscuteable homologue C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_15424</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01001615">
        <property type="protein sequence ID" value="KAB0790248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N3ZYZ4"/>
    <dbReference type="FunCoup" id="A0A5N3ZYZ4">
        <property type="interactions" value="69"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N3ZYZ4"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045179">
        <property type="term" value="C:apical cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008093">
        <property type="term" value="F:cytoskeletal anchor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045176">
        <property type="term" value="P:apical protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008356">
        <property type="term" value="P:asymmetric cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009786">
        <property type="term" value="P:regulation of asymmetric cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21966">
        <property type="entry name" value="INSC_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045789">
        <property type="entry name" value="Insc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039921">
        <property type="entry name" value="Inscuteable"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21386">
        <property type="entry name" value="INSCUTEABLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21386:SF0">
        <property type="entry name" value="PROTEIN INSCUTEABLE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19427">
        <property type="entry name" value="Insc_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein inscuteable homologue C-terminal" evidence="2">
        <location>
            <begin position="402"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0790248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="761" mass="85432" checksum="422E216B974AC405" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N3ZZ54</accession>
    <name>A0A5N3ZZ54_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_15323</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01001485">
        <property type="protein sequence ID" value="KAB0790329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N3ZZ54"/>
    <dbReference type="InParanoid" id="A0A5N3ZZ54"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33939:SF1">
        <property type="entry name" value="DUF4371 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33939">
        <property type="entry name" value="PROTEIN CBG22215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0790329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="216" mass="25117" checksum="3765953D5A8A9B7F" modified="2020-02-26" version="1">MAVQQRTADAVQVSKQTVVRTCAMREIGSDLKRNPYRRSKPRRTDLPENKKHTIRCLIYDMYANKEHVTLDTLLAVIKLKDLCDLGRTSLFYALKEMGFKFKMTNNRRGLCEQSHVVSMRNVFLRKYIKNLESEIPHDFVFLDETWVFSRGATKRTWQDDSVKSLQQPHKASDGKRYIIIHAGGRNGFIEGSSLIFSSTNKSFDYHDNMNAELFEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-06-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N3ZZG7</accession>
    <name>A0A5N3ZZG7_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_15190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01001278">
        <property type="protein sequence ID" value="KAB0790439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N3ZZG7"/>
    <dbReference type="InParanoid" id="A0A5N3ZZG7"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0790439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="76" mass="8691" checksum="03B92F89B79E99BF" modified="2020-02-26" version="1">MAAQGAAIVFGGVQTAYERELRTHLIEKYGSEHVAILRGRGTIPGSVKIEEDDFQGTRFQVFKDLELKHTYWVFYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N3ZZI4</accession>
    <name>A0A5N3ZZI4_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_15125</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01001218">
        <property type="protein sequence ID" value="KAB0790481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N3ZZI4"/>
    <dbReference type="InParanoid" id="A0A5N3ZZI4"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0790481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="60" mass="6846" checksum="9A543727AD9BB291" modified="2020-02-26" version="1" fragment="single">TICILHNTIIDKEGHHSFNGMDVPQIPSQCMLRRNRANNPSTRNAKTVRDTFAEYFSLNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N3ZZK3</accession>
    <name>A0A5N3ZZK3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_15097</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01001195">
        <property type="protein sequence ID" value="KAB0790501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N3ZZK3"/>
    <dbReference type="InParanoid" id="A0A5N3ZZK3"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF217">
        <property type="entry name" value="GLUCOSE DEHYDROGENASE [FAD, QUINONE]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="3">
        <location>
            <begin position="318"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0790501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="678" mass="75483" checksum="91A8D5539A38AAC4" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N3ZZX9</accession>
    <name>A0A5N3ZZX9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_14927</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000978">
        <property type="protein sequence ID" value="KAB0790634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N3ZZX9"/>
    <dbReference type="InParanoid" id="A0A5N3ZZX9"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33939:SF1">
        <property type="entry name" value="DUF4371 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33939">
        <property type="entry name" value="PROTEIN CBG22215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0790634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="277" mass="32323" checksum="78E545F6737D3B13" modified="2020-02-26" version="1">MAVQQRTADAVQVSKQTVVRTCAMREIGSDLKRNPYRRSKPRRTDLLENKKHTIRYLIYDMYANKEHVTLDTLLAVIKLKDLCDLGRTSLFYALKEMGFKFKMTNSRRGSCEQSHVVSMRNVFLRKYIRNLESEIPHDFVFLDETWVFSRGATKRTWQDDRAKNGKRYIIIHAGGRNGFIEGSSLIFSSTNKSFDYHDNMNAELFEKWFEESFLKKLAQPSIIVLDNASYHTRKSEKIPRASSTKEEISNWLKMKNRPFGTAMFKGAFARHGVRKVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A153</accession>
    <name>A0A5N4A153_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Carboxylesterase type B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PPYR_02850</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A153"/>
    <dbReference type="InParanoid" id="A0A5N4A153"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00312">
        <property type="entry name" value="Esterase_lipase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142:SF1">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024445858" description="Carboxylesterase type B domain-containing protein" evidence="6">
        <location>
            <begin position="22"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="7">
        <location>
            <begin position="22"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="7">
        <location>
            <begin position="586"/>
            <end position="1095"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0791050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1129" mass="126275" checksum="DCC2CB820DDE65BB" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A1N7</accession>
    <name>A0A5N4A1N7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Calponin-homology (CH) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_03035</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytospin-A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A1N7"/>
    <dbReference type="FunCoup" id="A0A5N4A1N7">
        <property type="interactions" value="602"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A1N7"/>
    <dbReference type="OrthoDB" id="10017054at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd21199">
        <property type="entry name" value="CH_CYTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000020">
        <property type="entry name" value="Cytospin-A isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050540">
        <property type="entry name" value="F-actin_Monoox_Mical"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23167">
        <property type="entry name" value="CALPONIN HOMOLOGY DOMAIN-CONTAINING PROTEIN DDB_G0272472-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23167:SF69">
        <property type="entry name" value="FI18193P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="4">
        <location>
            <begin position="791"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="9"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="47"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="616"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="668"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="56"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="669"/>
            <end position="704"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0791235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="897" mass="102522" checksum="ECAEE731A7A044B4" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A2C3</accession>
    <name>A0A5N4A2C3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PPYR_03280</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A2C3"/>
    <dbReference type="FunCoup" id="A0A5N4A2C3">
        <property type="interactions" value="2303"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A2C3"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16457">
        <property type="entry name" value="RING-H2_BRAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.750:FF:000001">
        <property type="entry name" value="TBC1 domain family member 10A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000008">
        <property type="entry name" value="TBC1 domain family member 10A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000007">
        <property type="entry name" value="TBC1 domain family member 10A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011422">
        <property type="entry name" value="BRAP2/ETP1_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047243">
        <property type="entry name" value="RING-H2_BRAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24007">
        <property type="entry name" value="BRCA1-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24007:SF7">
        <property type="entry name" value="BRCA1-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07576">
        <property type="entry name" value="BRAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00290">
        <property type="entry name" value="ZnF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="8">
        <location>
            <begin position="85"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="570"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="domain" description="UBP-type" evidence="10">
        <location>
            <begin position="607"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="855"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="748"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="811"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="867"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="881"/>
            <end position="890"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0791480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="890" mass="101028" checksum="D7422B1C3A2374A5" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A2J7</accession>
    <name>A0A5N4A2J7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Signal recognition particle 19 kDa protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PPYR_03319</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). Binds directly to 7SL RNA. Mediates binding of SRP54 to the SRP complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SRP19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A2J7"/>
    <dbReference type="FunCoup" id="A0A5N4A2J7">
        <property type="interactions" value="1296"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A2J7"/>
    <dbReference type="OrthoDB" id="2190947at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006617">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.56.30:FF:000002">
        <property type="entry name" value="Signal recognition particle 19kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.30">
        <property type="entry name" value="Signal recognition particle, SRP19-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002778">
        <property type="entry name" value="Signal_recog_particle_SRP19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036521">
        <property type="entry name" value="SRP19-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17453">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 19 KD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17453:SF0">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 19 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01922">
        <property type="entry name" value="SRP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69695">
        <property type="entry name" value="SRP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0733">Signal recognition particle</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="124"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0791519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="150" mass="16839" checksum="299224643A0566DA" modified="2020-02-26" version="1">MASNLIKGSSPYTLDSKHSDKERWICIYPAYINSKKTLAQGRKIAKEKCVENPTHQEMRDVLVAAGLKIGVENKLYSREKSKELLYRGRLRVQLKNDDGSPCDGRFTSRESLMCHLGEMIPKLKVRQTKGGGDQQQASSSKGKNKGKGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A3G5</accession>
    <name>A0A5N4A3G5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Vesicle transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PPYR_03684</name>
        <name evidence="11" type="ORF">PPYR_12576</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Membrane</location>
            <topology evidence="2 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the SFT2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0792956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A3G5"/>
    <dbReference type="FunCoup" id="A0A5N4A3G5">
        <property type="interactions" value="793"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A3G5"/>
    <dbReference type="OrthoDB" id="660759at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007305">
        <property type="entry name" value="Vesicle_transpt_Got1/SFT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011691">
        <property type="entry name" value="Vesicle_transpt_SFT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23137:SF36">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN SFT2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23137">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04178">
        <property type="entry name" value="Got1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="66"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="163"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0791884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0792956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="200" mass="22432" checksum="E759DC69ED096A7B" modified="2020-02-26" version="1">MADLKKDLDQYLLLQNDQKKSFKLQMPTIQKPNFSNWLKSESQEEETWFASTQKQCCPSLTRFQRIAGFCACVLMGILCFSISLMYIPVLILKARKFALLFTLGSVFFVLSFMFLWGPVAYLKHSFTRERIWLTVTYVFTLGVTLYCALHLQSTPFTVLGAVGQIITLLWSVVASVPGGATGVGVFSKIFSKSVGATLPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A436</accession>
    <name>A0A5N4A436_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein FAM98A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_14019</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM98 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A436"/>
    <dbReference type="FunCoup" id="A0A5N4A436">
        <property type="interactions" value="1346"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A436"/>
    <dbReference type="OrthoDB" id="512356at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072669">
        <property type="term" value="C:tRNA-splicing ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018797">
        <property type="entry name" value="FAM98"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31353">
        <property type="entry name" value="FAM98"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31353:SF1">
        <property type="entry name" value="PROTEIN FAM98B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10239">
        <property type="entry name" value="DUF2465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="297"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="384"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="329"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="384"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="401"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="422"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="448"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="475"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="490"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="538"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0792058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="587" mass="64037" checksum="01A6DE57095421E0" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A4B7</accession>
    <name>A0A5N4A4B7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Luciferin 4-monooxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_14099</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A4B7"/>
    <dbReference type="InParanoid" id="A0A5N4A4B7"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF149">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="5">
        <location>
            <begin position="22"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="6">
        <location>
            <begin position="429"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0792138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="521" mass="58965" checksum="8C8B8F95BF4E953C" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A572</accession>
    <name>A0A5N4A572_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Heat shock factor-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_14432</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Negative regulator of the heat shock response. Negatively affects HSF1 DNA-binding activity. May have a role in the suppression of the activation of the stress response during the aging process.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homohexamer. Associates with heptad repeats of HSF1 trimers and probably also HSF1 monomers, and with HSP70. Association with HSF1 trimers and HSP70 coincides with attenuation of heat shock response and the conversion of HSF1 trimer to monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HSBP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A572"/>
    <dbReference type="InParanoid" id="A0A5N4A572"/>
    <dbReference type="OrthoDB" id="4159489at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070370">
        <property type="term" value="P:cellular heat acclimation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.430:FF:000002">
        <property type="entry name" value="Heat shock factor-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009643">
        <property type="entry name" value="HS1-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19424">
        <property type="entry name" value="HEAT SHOCK FACTOR BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19424:SF0">
        <property type="entry name" value="HEAT SHOCK FACTOR BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06825">
        <property type="entry name" value="HSBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="48"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0792473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="83" mass="9441" checksum="3AD5EC4BC53BF545" modified="2020-02-26" version="1">MVDEKIEMNNDNETYTATGSSDPQNLQELTQYVQNLLESIQIKFQNMSDQILSRIDEMGNRIDDLEKNIGDLMTQAGVEGTEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A619</accession>
    <name>A0A5N4A619_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_14726</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A619"/>
    <dbReference type="FunCoup" id="A0A5N4A619">
        <property type="interactions" value="11"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A619"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006631">
        <property type="entry name" value="DM4_12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07841">
        <property type="entry name" value="DM4_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024432900" evidence="3">
        <location>
            <begin position="20"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="109"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0792767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="257" mass="27647" checksum="C377B9B6BE21CE32" modified="2020-02-26" version="1">MRNLLKGLTLAAFVAWVFANPKKYVSGDSDSGFHPNNQRYYESNLPGGSRHSNISESKEMKESSAINRYQRFGNLGLQPPSGYGNTGSGVQGYPPGGVGYNMVPMKIDIGGVALGAALGLGAVLLAPKLFSFFHMLAPGYRNSSSSNSSAISDILARIDNSLEEHHIDSSSCMQRIICSYVNEAQKNVQNGEQSTVDELLLNISNNSLVTYMLDGSAVKQAIDMGKQGDLDKCASLYVKCPISRENVLQVISSLLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A644</accession>
    <name>A0A5N4A644_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_14740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A644"/>
    <dbReference type="InParanoid" id="A0A5N4A644"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0792781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="280" mass="31126" checksum="CBA6DB6906973D31" modified="2020-02-26" version="1">MPICTLSCSSYGTGFGDLISDSKTLLRLIASKMLPQSWYPSGNYKCYPPVCGVCNRCLVVPKPVEIPEHCVKDIISTLYHRNKKCCHSVCPNRIVRRPSNITMRCYVGSRPDHNCCRVKRCRQTCCSRRVQTPSVESCTVKILCNTRNIDSKSTCAKPSCRSIKALKPVDSTCYFSDDCCPTPAPTVKFNPKCLPECAKPCDPCPKPCVSKPKSRRSVCEVVECKDDCPAVCADGVILRTVMYYCDLLSKPIVALPILSSIFCYVFKTVSDCIAGFKCYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-09-13" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A6Z8</accession>
    <name>A0A5N4A6Z8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CST complex subunit CTC1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_12712</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A6Z8"/>
    <dbReference type="InParanoid" id="A0A5N4A6Z8"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0793092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="691" mass="79106" checksum="04D894F6FE35B6F1" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A7K8</accession>
    <name>A0A5N4A7K8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Chitin-binding type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_12923</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A5N4A7K8">
        <property type="interactions" value="32"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A7K8"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050938">
        <property type="entry name" value="Collagen_Structural_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37456:SF5">
        <property type="entry name" value="COLLAGEN TYPE XIII ALPHA 1 CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37456">
        <property type="entry name" value="SI:CH211-266K2.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chitin-binding type-2" evidence="2">
        <location>
            <begin position="28"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="2">
        <location>
            <begin position="123"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="2">
        <location>
            <begin position="584"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="2">
        <location>
            <begin position="787"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="2">
        <location>
            <begin position="1008"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="2">
        <location>
            <begin position="1278"/>
            <end position="1338"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="2">
        <location>
            <begin position="1530"/>
            <end position="1590"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="2">
        <location>
            <begin position="1740"/>
            <end position="1806"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="2">
        <location>
            <begin position="1853"/>
            <end position="1913"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="2">
        <location>
            <begin position="1937"/>
            <end position="2001"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="640"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="847"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1069"/>
            <end position="1283"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="1339"/>
            <end position="1535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1590"/>
            <end position="1729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1814"/>
            <end position="1837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="255"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="477"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="560"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="648"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="721"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="853"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="885"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="931"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="952"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="991"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1074"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1098"/>
            <end position="1107"/>
        </location>
    </feature>
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        <location>
            <begin position="1133"/>
            <end position="1176"/>
        </location>
    </feature>
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        <location>
            <begin position="1201"/>
            <end position="1220"/>
        </location>
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        <location>
            <begin position="1230"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1346"/>
            <end position="1360"/>
        </location>
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        <location>
            <begin position="1367"/>
            <end position="1376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1382"/>
            <end position="1400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1406"/>
            <end position="1415"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1421"/>
            <end position="1442"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1462"/>
            <end position="1477"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1506"/>
            <end position="1526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1611"/>
            <end position="1635"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1646"/>
            <end position="1721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1814"/>
            <end position="1834"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0793303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="2028" mass="204020" checksum="B1AFCAD3BB122662" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A890</accession>
    <name>A0A5N4A890_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">FGFR1 oncogene partner (FOP) N-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_13166</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Centrosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CEP43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A890"/>
    <dbReference type="InParanoid" id="A0A5N4A890"/>
    <dbReference type="OrthoDB" id="5970631at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034453">
        <property type="term" value="P:microtubule anchoring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.960.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018993">
        <property type="entry name" value="FOP_dimerisation-dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15431:SF19">
        <property type="entry name" value="CENTROSOMAL PROTEIN 20-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15431">
        <property type="entry name" value="FGFR1 ONCOGENE PARTNER/LISH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09398">
        <property type="entry name" value="FOP_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FGFR1 oncogene partner (FOP) N-terminal dimerisation" evidence="8">
        <location>
            <begin position="53"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0793546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="126" mass="14782" checksum="9337BD88D10A3F0B" modified="2020-02-26" version="1">MSDPMEDHLFKEVKRNLEVDGRLQKFTAELRSTLISILNGRPPRDQNYNEIPKETRLINDLIREYLIWNGYIYTEEFLVAESGAEKEKPSREDLTEKLGIADDYSTTKIPLLYYIVCAFEMQEQST</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ABW6</accession>
    <name>A0A5N4ABW6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PPYR_11662</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0794823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ABW6"/>
    <dbReference type="InParanoid" id="A0A5N4ABW6"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051131">
        <property type="entry name" value="NEK_Ser/Thr_kinase_NIMA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899">
        <property type="entry name" value="CAMK FAMILY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0794823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="134" mass="14984" checksum="E6CA91EBB4D9D1FF" modified="2020-02-26" version="1">MHSFNILQKLGKGTFGETKTQTFIGTANYLAPEMCHGKPYNTKSDIWSLGCILYELCALERMFDGPVANVVYSISTGRKKLINSSLYETGVQYLVEVMLQLEPANRPDTVSLMKFPVLLQTMYTLGVTLGCIKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ACF3</accession>
    <name>A0A5N4ACF3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PPYR_11830</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the paired homeobox family. Bicoid subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0794991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ACF3"/>
    <dbReference type="InParanoid" id="A0A5N4ACF3"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000223">
        <property type="entry name" value="Goosecoid homeobox 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051440">
        <property type="entry name" value="Goosecoid-like_HB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46643:SF1">
        <property type="entry name" value="HOMEOBOX PROTEIN GOOSECOID-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46643">
        <property type="entry name" value="HOMEOBOX PROTEIN GOOSECOID-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="9">
        <location>
            <begin position="150"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="152"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="210"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="139"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="211"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0794991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="253" mass="28545" checksum="71FEB6913B7DDF87" modified="2020-02-26" version="1">MVETANHQQHHQIGTSSNIWNPHSFLGNMFFAGEGFKPVQRMTRSTPVTATVASSTSSSLFTIDSILAPRPNPASPQRPILHHPLHFGHIAAAASASFGASCTSAEFLAMAYPGLYPGYVHALAAASQAASMSGAGPNTHHHHPQHQPPKRKRRHRTIFSEEQLEQLEATFEQTHYPDVVLREQLALKVDLKEERVEVWFKNRRAKWRKQKREEQERMRKLQEEEVCRVVEQPRLLAPPPHYSDDDSSDLEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AEA6</accession>
    <name>A0A5N4AEA6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_09724</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0795663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AEA6"/>
    <dbReference type="FunCoup" id="A0A5N4AEA6">
        <property type="interactions" value="1327"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AEA6"/>
    <dbReference type="OrthoDB" id="46189at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033370">
        <property type="entry name" value="COG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31658">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31658:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08700">
        <property type="entry name" value="VPS51_Exo84_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="164"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0795663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="878" mass="100887" checksum="5AE667552D14B534" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AFA4</accession>
    <name>A0A5N4AFA4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein 70</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_10052</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TMEM70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0795991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AFA4"/>
    <dbReference type="FunCoup" id="A0A5N4AFA4">
        <property type="interactions" value="1001"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AFA4"/>
    <dbReference type="OrthoDB" id="156886at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009724">
        <property type="entry name" value="TMEM70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045325">
        <property type="entry name" value="TMEM70/TMEM186/TMEM223"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13281">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 70, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13281:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 70, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06979">
        <property type="entry name" value="TMEM70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0795991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="208" mass="23763" checksum="90E13040E9632262" modified="2020-02-26" version="1">MSLNACLILLPRVFRSSQCKSVITKNYMLYKNLYLCRLQSTTQNRNEVLVYHGTLTTQLRGVKVFSLMTSLTGIVAQPFIYTQLMSLNNVPLMIVAWSFFGLFTIGTPLLLHLLARKYVTTLKYKPETDTYVATTLNLFNIAKELEFKPADVKVPEVLGMFTSFTAKDKALFVDPRFFSDPKHYGRIMGYDKPLDFKLCKSNISEGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AG89</accession>
    <name>A0A5N4AG89_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">PPYR_10398</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">1611_PpyrPB1</strain>
            <tissue evidence="22">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="3"/>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A5N4AG89">
        <property type="interactions" value="270"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AG89"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048666">
        <property type="term" value="P:neuron development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="CDD" id="cd14553">
        <property type="entry name" value="R-PTPc-LAR-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000107">
        <property type="entry name" value="Myosin, light chain kinase a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000551">
        <property type="entry name" value="Protogenin A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000010">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase delta isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000002">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase delta isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000151">
        <property type="entry name" value="Receptor-type tyrosine-protein phosphatase S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001111">
        <property type="entry name" value="tyrosine-protein phosphatase Lar isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001197">
        <property type="entry name" value="tyrosine-protein phosphatase Lar isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001219">
        <property type="entry name" value="tyrosine-protein phosphatase Lar isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001000">
        <property type="entry name" value="tyrosine-protein phosphatase Lar isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001130">
        <property type="entry name" value="tyrosine-protein phosphatase Lar isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001015">
        <property type="entry name" value="tyrosine-protein phosphatase Lar isoform X4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001564">
        <property type="entry name" value="tyrosine-protein phosphatase Lar isoform X4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001191">
        <property type="entry name" value="Uncharacterized protein, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050713">
        <property type="entry name" value="RTP_Phos/Ushers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46957">
        <property type="entry name" value="CYTOKINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46957:SF6">
        <property type="entry name" value="PROTEIN-TYROSINE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00014">
        <property type="entry name" value="FNTYPEIII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="10 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1309"/>
            <end position="1332"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="20">
        <location>
            <begin position="62"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="20">
        <location>
            <begin position="161"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="21">
        <location>
            <begin position="252"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="21">
        <location>
            <begin position="347"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="21">
        <location>
            <begin position="445"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="21">
        <location>
            <begin position="541"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="21">
        <location>
            <begin position="639"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="21">
        <location>
            <begin position="744"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="21">
        <location>
            <begin position="841"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="21">
        <location>
            <begin position="938"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="21">
        <location>
            <begin position="1034"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="18">
        <location>
            <begin position="1404"/>
            <end position="1659"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="19">
        <location>
            <begin position="1579"/>
            <end position="1650"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="18">
        <location>
            <begin position="1691"/>
            <end position="1950"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="19">
        <location>
            <begin position="1868"/>
            <end position="1941"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="722"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1266"/>
            <end position="1291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="1278"/>
            <end position="1291"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="22">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAB0796337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1959" mass="220823" checksum="3CE199AAF13FA88E" modified="2020-02-26" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AGI8</accession>
    <name>A0A5N4AGI8_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_10498</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the insect beta-1,3-glucan binding protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AGI8"/>
    <dbReference type="InParanoid" id="A0A5N4AGI8"/>
    <dbReference type="OrthoDB" id="4781at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2140">
        <property type="entry name" value="Beta-1,3-glucan-recognition protein, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031756">
        <property type="entry name" value="BGBP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043030">
        <property type="entry name" value="BGBP_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF60">
        <property type="entry name" value="GRAM-NEGATIVE BACTERIA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15886">
        <property type="entry name" value="CBM39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51969">
        <property type="entry name" value="CBM39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0391">Immunity</keyword>
    <keyword evidence="2" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024292502" evidence="4">
        <location>
            <begin position="19"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="CBM39" evidence="6">
        <location>
            <begin position="20"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="5">
        <location>
            <begin position="169"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0796437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="450" mass="51062" checksum="56197AA6965DDF53" modified="2020-02-26" version="1">MFVNRILCVLSFIYAVKGDYAVPSLTLEALKKGGFRVYIPDVPGTALFAFHANINDNIRAQHPGSVNGEARTPTNGFWILEFNDKLKQGDVVNYWLFVNANHLGYRKDGEPIKITRLLDAYTELKGRCEPGSTVINGGKATCVDNVIFQDKFDGSTINTMLWKVEHRIPTYSEPNSPFNSYENREDTKFIKDNKLHLKPNAVPESDVRGTLNLREGCTGTKEIECFYEQRSSFLLPPVKASKVVSTTSFKYGKVEIRAKLPRGDWIFPIVQLEFAQRDIANPSKIWIAYSRGNTKLIMSDPNDIDVRGFSGTDIGGRLLLAGPTLEEREPQRSKRLVHKYADQPFSDDYHTYGLVWTKDQMRFYVDSEEYGSVDLSTENLDRECVLSLGVGVGGLFDFPEGTYSGSNYKPWSNEDRNAIKRFFEKKPIWVQTWDDEKSCLIVDHVQITAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AGS0</accession>
    <name>A0A5N4AGS0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">guanylate kinase</fullName>
            <ecNumber evidence="2">2.7.4.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PPYR_10621</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the guanylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.8" evidence="2"/>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AGS0"/>
    <dbReference type="FunCoup" id="A0A5N4AGS0">
        <property type="interactions" value="1980"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AGS0"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004385">
        <property type="term" value="F:GMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00071">
        <property type="entry name" value="GMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.63.10:FF:000002">
        <property type="entry name" value="Guanylate kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000776">
        <property type="entry name" value="Guanylate kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017665">
        <property type="entry name" value="Guanylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020590">
        <property type="entry name" value="Guanylate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03263">
        <property type="entry name" value="guanyl_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23117:SF13">
        <property type="entry name" value="GUANYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23117">
        <property type="entry name" value="GUANYLATE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00856">
        <property type="entry name" value="GUANYLATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Guanylate kinase-like" evidence="7">
        <location>
            <begin position="65"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0796560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="257" mass="29224" checksum="17F06078710921DF" modified="2020-02-26" version="1">MLCHEIKFIEDIKFYLDDNDRKKCEFELRPTFDFANSIKRESQFAHLTITINFIRALHKMATNGPKPLVFCGPSGSGKSTMLTKLLVDYPTHFGFSVSHTTRLPREGEVDGVHYHFTTVKQMKEDINEGKFIESATFGGNMYGTSIKAVEVVRDSGKVCILDIDVQGVKQVKQTSLNPWYVFVKPPSLDALEERLKKRKTENLTSLTLRLQAAQKEIEYGEEAGNFDLLVINDDLHHAYDEIKKFVEDKVLCGNNIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AH22</accession>
    <name>A0A5N4AH22_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Heat shock protein 70</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_10706</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AH22"/>
    <dbReference type="InParanoid" id="A0A5N4AH22"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000545">
        <property type="entry name" value="Endoplasmic reticulum chaperone BiP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000172">
        <property type="entry name" value="Heat shock 70 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000001">
        <property type="entry name" value="heat shock 70 kDa protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="553"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0796645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="572" mass="63266" checksum="967348E2A7E1C835" modified="2020-02-26" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AI93</accession>
    <name>A0A5N4AI93_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">LITAF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PPYR_11108</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Late endosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Lysosome membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CDIP1/LITAF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0797047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AI93"/>
    <dbReference type="InParanoid" id="A0A5N4AI93"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006629">
        <property type="entry name" value="LITAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037519">
        <property type="entry name" value="LITAF_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23292:SF6">
        <property type="entry name" value="FI16602P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23292">
        <property type="entry name" value="LIPOPOLYSACCHARIDE-INDUCED TUMOR NECROSIS FACTOR-ALPHA FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10601">
        <property type="entry name" value="zf-LITAF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00714">
        <property type="entry name" value="LITAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51837">
        <property type="entry name" value="LITAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="LITAF" evidence="10">
        <location>
            <begin position="70"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="37"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0797047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="158" mass="17267" checksum="72DB81B87EA35F64" modified="2020-02-26" version="1">MEKIPPPPPYEESTHSPPLNNYSQAYPPQSRNAGYPTLPPPQMGFPPPPQVGFQQPGFIPQPTPSVPQAQYSRYPQPQVVTVFGPIPQLINCPHCHNQVTSKLEASAGTKTHLFAALLCILGCIPCCLIPYCVDSCKDRSHYCPQCNAFLGSYGTALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AIQ5</accession>
    <name>A0A5N4AIQ5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PPYR_08201</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">1611_PpyrPB1</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AIQ5"/>
    <dbReference type="InParanoid" id="A0A5N4AIQ5"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031519">
        <property type="term" value="C:PcG protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000646">
        <property type="entry name" value="Myeloid zinc finger 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002070">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000690">
        <property type="entry name" value="Zinc finger protein 354C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001498">
        <property type="entry name" value="Zinc finger protein 404"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000176">
        <property type="entry name" value="zinc finger protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003:SF23">
        <property type="entry name" value="ZINC FINGER PROTEIN 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BTB" evidence="13">
        <location>
            <begin position="19"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="317"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="347"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="375"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="403"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="431"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="459"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="487"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAB0797207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="518" mass="58773" checksum="B749BA188A0F2518" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AJE6</accession>
    <name>A0A5N4AJE6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_08465</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AJE6"/>
    <dbReference type="InParanoid" id="A0A5N4AJE6"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051487">
        <property type="entry name" value="Ser/Thr_Proteases_Immune/Dev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24256">
        <property type="entry name" value="TRYPTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024366470" description="Peptidase S1 domain-containing protein" evidence="3">
        <location>
            <begin position="18"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="4">
        <location>
            <begin position="83"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0797472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="331" mass="37603" checksum="41EB9901A6F29BE4" modified="2020-02-26" version="1">MNSDWISFILLISNALACDETKCVTLSLCPALQRYVTNPTTNYTVRNVERLICEVDEDVRVCCDQMAIANFETESKPFYKNAKTCGSQDPTYEFPWLVSFMGFGASICSGALLNERYVLTSASCISHNATEYIFDILLGDINLKNNSCNETYGAPEECLQVKSLSIEEAIPHPLFNGTFNNVGLIRLNESVLYTEYIQPICLPNATSIRPALNSMYTSGFAVHFDPKTEREKWKRNTTIILKSLDTCKEWYKSHGRTITLNELNFCSIDKDDTPPEFANTILDRGAPVVTFHNNQWYAEGIVSLAEEERQRPIVHTNLTYYVDWIHSNMKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AKD2</accession>
    <name>A0A5N4AKD2_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glycolipid transfer protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_08762</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GLTP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AKD2"/>
    <dbReference type="FunCoup" id="A0A5N4AKD2">
        <property type="interactions" value="397"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AKD2"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902387">
        <property type="term" value="F:ceramide 1-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902388">
        <property type="term" value="F:ceramide 1-phosphate transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032691">
        <property type="term" value="P:negative regulation of interleukin-1 beta production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3520.10:FF:000002">
        <property type="entry name" value="Ceramide-1-phosphate transfer protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3520.10">
        <property type="entry name" value="Glycolipid transfer protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036497">
        <property type="entry name" value="GLTP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014830">
        <property type="entry name" value="Glycolipid_transfer_prot_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10219:SF43">
        <property type="entry name" value="GLYCOLIPID TRANSFER PROTEIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10219">
        <property type="entry name" value="GLYCOLIPID TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08718">
        <property type="entry name" value="GLTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110004">
        <property type="entry name" value="Glycolipid transfer protein, GLTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycolipid transfer protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0797769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="210" mass="24369" checksum="8DB2394B364508DC" modified="2020-02-26" version="1">MSNFDISLIHNNFQQSLAEENDVALKEYLDGYEELNKFCNLMGVIFGFVSKDLRSKMDILYDYLKDSNNSQNYTTVKQMIEYEKQTKLLDRKDFTSGSRTLLRLHRGLDFLRVFLKGVSELKDNENTSPVGRAAYDKTLSHHHTFVVRNGARLAMHTMPTREQLLKKLCGENAEEIERTITTLPKMLDVTTVVFDRIDNLYTVHELHTLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AL22</accession>
    <name>A0A5N4AL22_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">MSP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_09010</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AL22"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904158">
        <property type="term" value="P:axonemal central apparatus assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003341">
        <property type="term" value="P:cilium movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054090">
        <property type="entry name" value="Cep192_Spd-2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033305">
        <property type="entry name" value="Hydin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053879">
        <property type="entry name" value="HYDIN_VesB_CFA65-like_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23053">
        <property type="entry name" value="DLEC1 DELETED IN LUNG AND ESOPHAGEAL CANCER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23053:SF0">
        <property type="entry name" value="HYDROCEPHALUS-INDUCING PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22073">
        <property type="entry name" value="Cep192_D4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22544">
        <property type="entry name" value="HYDIN_VesB_CFA65-like_Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cep192/Spd-2-like" evidence="7">
        <location>
            <begin position="613"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="domain" description="HYDIN/VesB/CFA65-like Ig-like" evidence="8">
        <location>
            <begin position="1818"/>
            <end position="1905"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="472"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1091"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1733"/>
            <end position="1753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="481"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1739"/>
            <end position="1748"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF22544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0798017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2297" mass="256649" checksum="BF12B42988CA4DBA" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AL26</accession>
    <name>A0A5N4AL26_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_09007</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AL26"/>
    <dbReference type="FunCoup" id="A0A5N4AL26">
        <property type="interactions" value="33"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AL26"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051217">
        <property type="entry name" value="Insect_Cuticle_Struc_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236:SF75">
        <property type="entry name" value="CUTICULAR PROTEIN 62BB, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236">
        <property type="entry name" value="STRUCTURAL CONTITUENT OF CUTICLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00947">
        <property type="entry name" value="CUTICLE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024397386" evidence="3">
        <location>
            <begin position="27"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0798014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="288" mass="31485" checksum="F6D312B0B1EAEF37" modified="2020-02-26" version="1">MGDMSIFSRRNVVLLALAVVVSVTRAVPVDYHGVYAPVHAVPVHAEPVAYPKYTYKYGVNDYHTGDIKSQHETRDGDVVKGQYSVVEPDGSIRTVDYTADKHNGFNAVILTVSFACMVQVVLGRPGYAGHAVDYYSPPSYAFKYGVTDLHTGDVKSQQETRVGGVVKGQYSLVEPDGSIRTVDYKADPVHGFNAVVSKSPPFSGHPPPPPPPPPINRVQIIPAVVKKLVPAPPPPPRPPVIFPRITKQHYPTPILGSYGNGYYDDYQETYGDGYGNIYFYDGAGYGHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-06-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ALC5</accession>
    <name>A0A5N4ALC5_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_09110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ALC5"/>
    <dbReference type="InParanoid" id="A0A5N4ALC5"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0798117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="112" mass="12951" checksum="B7E12B3B46BA72F4" modified="2020-02-26" version="1">MATEMQDQNENQADNPQADKNISTGDYVAVTFLCENNKKTKFFAGEVTNISDNGQEFTINFFRKQTLKGTYFTFPHVQDKQTVAKEDIVSKLCLKRVVRGRFYFSMPDYNLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ALJ4</accession>
    <name>A0A5N4ALJ4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitin synthase</fullName>
            <ecNumber evidence="2">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PPYR_09169</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">1611_PpyrPB1</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the chitin synthase family. Class IV subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2"/>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A5N4ALJ4">
        <property type="interactions" value="37"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4ALJ4"/>
    <dbReference type="OrthoDB" id="370884at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000139">
        <property type="entry name" value="Chitin synthase 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055120">
        <property type="entry name" value="Chs-1/2_IV_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF42">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03142">
        <property type="entry name" value="Chitin_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23000">
        <property type="entry name" value="ChitinSynthase_IV_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="163"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="253"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="296"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="376"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="406"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="914"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="947"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="971"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1005"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1033"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1270"/>
            <end position="1289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1327"/>
            <end position="1348"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin synthase chs-1/2 N-terminal putative transporter" evidence="16">
        <location>
            <begin position="67"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1183"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1532"/>
            <end position="1558"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="1063"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1536"/>
            <end position="1558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00046329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF23000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAB0798176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1558" mass="177391" checksum="D30B0599542CA399" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AMC7</accession>
    <name>A0A5N4AMC7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_09498</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AMC7"/>
    <dbReference type="InParanoid" id="A0A5N4AMC7"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021896">
        <property type="entry name" value="THAP9-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048366">
        <property type="entry name" value="TNP-like_GBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048367">
        <property type="entry name" value="TNP-like_RNaseH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048365">
        <property type="entry name" value="TNP-like_RNaseH_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47577:SF2">
        <property type="entry name" value="THAP DOMAIN CONTAINING 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47577">
        <property type="entry name" value="THAP DOMAIN-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21788">
        <property type="entry name" value="TNP-like_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21789">
        <property type="entry name" value="TNP-like_RNaseH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21787">
        <property type="entry name" value="TNP-like_RNaseH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12017">
        <property type="entry name" value="Tnp_P_element"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THAP9-like helix-turn-helix" evidence="1">
        <location>
            <begin position="7"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="Transposable element P transposase-like RNase H" evidence="2">
        <location>
            <begin position="91"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Transposable element P transposase-like GTP-binding insertion" evidence="3">
        <location>
            <begin position="252"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="Transposable element P transposase-like RNase H C-terminal" evidence="4">
        <location>
            <begin position="443"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF21789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0798505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="701" mass="80760" checksum="6D32D24F8E61B8D6" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ANS4</accession>
    <name>A0A5N4ANS4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_06875</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0798995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ANS4"/>
    <dbReference type="InParanoid" id="A0A5N4ANS4"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="3">
        <location>
            <begin position="11"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0798995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="144" mass="16725" checksum="A5EFBF65B4C03033" modified="2020-02-26" version="1">MHRFNNGDFGNSILLGDSGYMNLSYLFTPFLNVQNDGERNYNRSHVQSRVKVENLFGVWKRRFPIIAYGCRMKLENVLCVIVATAVLHNLARLRGEPEPPIENLIMEHELQQAIRDGDIPLAAEENDLGYDYRRHLVDIYFSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AQ32</accession>
    <name>A0A5N4AQ32_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Lipase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PPYR_07317</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AQ32"/>
    <dbReference type="FunCoup" id="A0A5N4AQ32">
        <property type="interactions" value="111"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AQ32"/>
    <dbReference type="OrthoDB" id="9974421at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000021">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006693">
        <property type="entry name" value="AB_hydrolase_lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025483">
        <property type="entry name" value="Lipase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11005">
        <property type="entry name" value="LYSOSOMAL ACID LIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04083">
        <property type="entry name" value="Abhydro_lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000862">
        <property type="entry name" value="Steryl_ester_lip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Partial AB-hydrolase lipase" evidence="9">
        <location>
            <begin position="39"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="349"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000862-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0799437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="404" mass="45955" checksum="4C4090C1ECC94F69" modified="2020-02-26" version="1">MLVRGLVVAILTTYSHQDAQWYGDLQLNLKVTEDAKLLVPDIIAKYGYPCEIHTVVSQDGYILEMHRIPFGKDGPSENRSAVYVQHGLLSSSADWILKGKTSLGYALADAGYDVWLANVRGTRYSRRHMFLNPDKNASSFWDFSWHNIGVDDVPTMIDYILITVKQRNIFYIGHSQGTTVFFVMCSERPQYNEKIRAMFSFAPVAWLKYMTSPLLRVISMADSAVGSLFQAIGMYEFLPQRSFLADIGGVLCGDDSLLQPLCANALFAICGFNQKQMNASLIPIIMGHTPAGAATKQFLHYTQQVNSGHFRQYDYGLFANIGKYGSAYPPDYQMKKVVAPVYLYYSRNDWLSHEIDVIRLSEELGNLKDKFIIIDDKFNHLDYLYGIDVYELLYKRVIALMKQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AQS0</accession>
    <name>A0A5N4AQS0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF5641 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_07585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AQS0"/>
    <dbReference type="InParanoid" id="A0A5N4AQS0"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040676">
        <property type="entry name" value="DUF5641"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF1">
        <property type="entry name" value="GAG-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18701">
        <property type="entry name" value="DUF5641"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5641" evidence="1">
        <location>
            <begin position="250"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0799705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="371" mass="42660" checksum="748740CA49A5C781" modified="2020-02-26" version="1" fragment="single">RFSSWTKLLRTTAIVLRFLKRLPGRGQLTAVDLETAENVLLQIVQKRHFINDIRLLENTGTCSAALVKYRPFLRDGLLRVGGRLENSQLSFDSQHPILLPKRDHLVNLLIEYYHHRGSNFVGAKSQLKDLFELIRSENFKTQIEAELTIKGIQWNFIAPGAPHMGGLWESNIKSVKSHLLKIVGDQLLTYEELNTLLIQIECLLNSRPLCVLSSDPAEPIALTPAHFLTLTPLDRLPAINVMDVNLSRLSRYQLIDHMVQHFWQRWRIEYLHTMQTREKLGSRFSSTLILHTPNPYRNQNANAVTQVTTPTEVRRATDGQTYAYRASHRAVTETEKECTVLDIERDIGHLQPYSAYNCTTYAVLRLSEIYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AR56</accession>
    <name>A0A5N4AR56_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Bifunctional glutamate/proline--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.15</ecNumber>
            <ecNumber evidence="3">6.1.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Bifunctional aminoacyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">PPYR_07669</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">1611_PpyrPB1</strain>
            <tissue evidence="22">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>tRNA(Glu) + L-glutamate + ATP = L-glutamyl-tRNA(Glu) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9663"/>
            <dbReference type="Rhea" id="RHEA-COMP:9680"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.17"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:23541"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>tRNA(Pro) + L-proline + ATP = L-prolyl-tRNA(Pro) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:14305"/>
            <dbReference type="Rhea" id="RHEA-COMP:9700"/>
            <dbReference type="Rhea" id="RHEA-COMP:9702"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78532"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.15"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:14306"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="16">In the N-terminal section; belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.15" evidence="2"/>
    <dbReference type="EC" id="6.1.1.17" evidence="3"/>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A5N4AR56">
        <property type="interactions" value="1397"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AR56"/>
    <dbReference type="OrthoDB" id="1350766at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004818">
        <property type="term" value="F:glutamate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004827">
        <property type="term" value="F:proline-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006433">
        <property type="term" value="P:prolyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00807">
        <property type="entry name" value="GlnRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00862">
        <property type="entry name" value="ProRS_anticodon_zinc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00778">
        <property type="entry name" value="ProRS_core_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00936">
        <property type="entry name" value="WEPRS_RNA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.10:FF:000006">
        <property type="entry name" value="Bifunctional glutamate/proline--tRNA ligase"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.110.30:FF:000001">
        <property type="entry name" value="Bifunctional glutamate/proline--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000007">
        <property type="entry name" value="Bifunctional glutamate/proline--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000070">
        <property type="entry name" value="Bifunctional glutamate/proline--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000005">
        <property type="entry name" value="bifunctional glutamate/proline--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1160.10:FF:000001">
        <property type="entry name" value="Glutamine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.800.10:FF:000001">
        <property type="entry name" value="Glutamine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.30">
        <property type="entry name" value="C-terminal domain of ProRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1160.10">
        <property type="entry name" value="Glutamyl-trna Synthetase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.800.10">
        <property type="entry name" value="Glutamyl-tRNA Synthetase, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="entry name" value="Ribosomal Protein L25, Chain P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.10">
        <property type="entry name" value="S15/NS1, RNA-binding"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01571">
        <property type="entry name" value="Pro_tRNA_synth_type3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004526">
        <property type="entry name" value="Glu-tRNA-synth_arc/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020059">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_codon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020061">
        <property type="entry name" value="Glu_tRNA_lig_a-bdl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004499">
        <property type="entry name" value="Pro-tRNA-ligase_IIa_arc-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016061">
        <property type="entry name" value="Pro-tRNA_ligase_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017449">
        <property type="entry name" value="Pro-tRNA_synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033721">
        <property type="entry name" value="ProRS_core_arch_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_bL25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_bL25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049437">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009068">
        <property type="entry name" value="uS15_NS1_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000738">
        <property type="entry name" value="WHEP-TRS_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00463">
        <property type="entry name" value="gltX_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00408">
        <property type="entry name" value="proS_fam_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43382:SF2">
        <property type="entry name" value="BIFUNCTIONAL GLUTAMATE_PROLINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43382">
        <property type="entry name" value="PROLYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09180">
        <property type="entry name" value="ProRS-C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03950">
        <property type="entry name" value="tRNA-synt_1c_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20974">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00458">
        <property type="entry name" value="WHEP-TRS"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SMART" id="SM00946">
        <property type="entry name" value="ProRS-C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00991">
        <property type="entry name" value="WHEP-TRS"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64586">
        <property type="entry name" value="C-terminal domain of ProRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="Ribosomal protein L25-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47060">
        <property type="entry name" value="S15/NS1 RNA-binding domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00762">
        <property type="entry name" value="WHEP_TRS_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51185">
        <property type="entry name" value="WHEP_TRS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="WHEP-TRS" evidence="21">
        <location>
            <begin position="539"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="domain" description="WHEP-TRS" evidence="21">
        <location>
            <begin position="603"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="domain" description="WHEP-TRS" evidence="21">
        <location>
            <begin position="677"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="domain" description="WHEP-TRS" evidence="21">
        <location>
            <begin position="746"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="domain" description="WHEP-TRS" evidence="21">
        <location>
            <begin position="813"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="20">
        <location>
            <begin position="951"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="515"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="862"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="515"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="874"/>
            <end position="896"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00050792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00061295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00067786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00076053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAB0799789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1405" mass="159027" checksum="B0DD7D7511FC98DE" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AT89</accession>
    <name>A0A5N4AT89_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_06188</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000004">
        <property type="protein sequence ID" value="KAB0800448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AT89"/>
    <dbReference type="InParanoid" id="A0A5N4AT89"/>
    <dbReference type="OrthoDB" id="8193799at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024445279" evidence="2">
        <location>
            <begin position="23"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0800448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="239" mass="26672" checksum="B5AD5BDBB038840F" modified="2020-02-26" version="1">MERCLTLLIVTIFFIKLSSVESLRVPENLDELIESGANIAYIKRYNNGDDGDNERGYHKVSNDKGGDGYKHFDSFHKTDSDKYGYETHSAFGKSAGNDDESGENVKYTQEGDKQKADYEDEQYNDKDVEERESKNAYKIVDNEGDSNYYSEGNADAAAALGYVGEYNAGGGDSRLYDNGGETYSQEQPEHYEVEENVDEADNEAGNYESRGNEDEIAAYETDGGEESAGEHYTAHDADY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AU19</accession>
    <name>A0A5N4AU19_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cuticle protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_06449</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000004">
        <property type="protein sequence ID" value="KAB0800710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AU19"/>
    <dbReference type="InParanoid" id="A0A5N4AU19"/>
    <dbReference type="OrthoDB" id="8021718at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051217">
        <property type="entry name" value="Insect_Cuticle_Struc_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236:SF75">
        <property type="entry name" value="CUTICULAR PROTEIN 62BB, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236">
        <property type="entry name" value="STRUCTURAL CONTITUENT OF CUTICLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00947">
        <property type="entry name" value="CUTICLE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024284163" description="Cuticle protein" evidence="3">
        <location>
            <begin position="18"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0800710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="205" mass="21717" checksum="44D57C013FAC09A3" modified="2020-02-26" version="1">MALKVFVFAAIVAFAAAAVAPVPAPLHPEEFNPHPQYAFNYAVQEPTTGDFKTQSESRDGGTVQGRYTVLEPNGLERVVEYTADDVNGFNAVVSHTPTGAAHVAPAPVAKVAAPLPAAVVPAKIAAPVVKEVKPVHPVAAPFGFGPHGYSGYPGYPAYTGFHGYRGYSGYHGYPGYTGYPGYSGFHGYPHGHRSPFYSGHHPGYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AUX5</accession>
    <name>A0A5N4AUX5_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_05480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000003">
        <property type="protein sequence ID" value="KAB0801126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AUX5"/>
    <dbReference type="InParanoid" id="A0A5N4AUX5"/>
    <dbReference type="OrthoDB" id="6760539at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34239">
        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34239:SF2">
        <property type="entry name" value="TRANSPOSABLE ELEMENT P TRANSPOSASE_THAP9 CONSERVED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0801126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="324" mass="36537" checksum="892B5BB99ED8FFEF" modified="2020-02-26" version="1">MGKNKKRPSDTEMSVLKKKMRKMQRFMSEFAEKFKDDSSSDSGTSQSEFSRNDSSASDPDNVSNVSPVQLTQAEVHNNTEIDTLLGESPLVQSALGPPILDELSVRWTSFLRIGLDKDTKETWCLLENCAALASPVMNPEIQLLLYANEAKSDSYMSHLQSTVGRGLSALGPVLTKLLNKESIIDINTLIPDLVDVSKFMGQTHYLLWQHRRHMVYPKLNPSIQKVAKDCPLDSYLFGENLTDRCKAAQSLQKSCLEMRAASAKSFDKTQPSASKNRSAQPPRSKYKKPEGSAKSKNQDQRQRTYRSSGKMPSYSYYRNNRQRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AVZ8</accession>
    <name>A0A5N4AVZ8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">SD-repeat containing protein B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PPYR_05764</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">1611_PpyrPB1</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000003">
        <property type="protein sequence ID" value="KAB0801410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AVZ8"/>
    <dbReference type="FunCoup" id="A0A5N4AVZ8">
        <property type="interactions" value="1970"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AVZ8"/>
    <dbReference type="OrthoDB" id="10263633at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1120">
        <property type="entry name" value="Carboxypeptidase-like, regulatory domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055075">
        <property type="entry name" value="NOMO-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055074">
        <property type="entry name" value="NOMO1-3_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055073">
        <property type="entry name" value="NOMO1-like_9th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056191">
        <property type="entry name" value="NOMO_12th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056190">
        <property type="entry name" value="NOMO_5th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056319">
        <property type="entry name" value="NOMO_7th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051417">
        <property type="entry name" value="SDr/BOS_complex"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23303:SF14">
        <property type="entry name" value="BOS COMPLEX SUBUNIT NOMO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23303">
        <property type="entry name" value="CARBOXYPEPTIDASE REGULATORY REGION-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23141">
        <property type="entry name" value="Ig_NOMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22898">
        <property type="entry name" value="NOMO1-like_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22904">
        <property type="entry name" value="NOMO1-like_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22902">
        <property type="entry name" value="NOMO1-like_9th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23192">
        <property type="entry name" value="NOMO_12th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23194">
        <property type="entry name" value="NOMO_5th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="Carboxypeptidase regulatory domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49478">
        <property type="entry name" value="Cna protein B-type domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="Starch-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024439241" description="SD-repeat containing protein B domain-containing protein" evidence="8">
        <location>
            <begin position="19"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1091"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="domain" description="NOMO-like N-terminal beta-sandwich" evidence="9">
        <location>
            <begin position="25"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="NOMO second beta-sandwich" evidence="11">
        <location>
            <begin position="111"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="NOMO fifth transthyretin-like" evidence="14">
        <location>
            <begin position="386"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="NOMO seventh transthyretin-like" evidence="12">
        <location>
            <begin position="562"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="domain" description="NOMO-like ninth beta-sandwich" evidence="10">
        <location>
            <begin position="720"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="domain" description="NOMO C-terminal transthyretin-like" evidence="13">
        <location>
            <begin position="978"/>
            <end position="1076"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF22898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF22902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF22904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF23141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF23192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF23194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAB0801410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1168" mass="130379" checksum="79B96226E71B7CF8" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AX65</accession>
    <name>A0A5N4AX65_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 15">Pyruvate kinase</fullName>
            <ecNumber evidence="5 15">2.7.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PPYR_04115</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">1611_PpyrPB1</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>pyruvate + ATP = phosphoenolpyruvate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18157"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.40"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 15">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the pyruvate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.40" evidence="5 15"/>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0801929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AX65"/>
    <dbReference type="FunCoup" id="A0A5N4AX65">
        <property type="interactions" value="573"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AX65"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004743">
        <property type="term" value="F:pyruvate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00288">
        <property type="entry name" value="Pyruvate_Kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.60:FF:000025">
        <property type="entry name" value="Pyruvate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1380.20:FF:000001">
        <property type="entry name" value="Pyruvate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.33.10:FF:000023">
        <property type="entry name" value="Pyruvate kinase PKM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.33.10">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.20">
        <property type="entry name" value="Pyruvate kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001697">
        <property type="entry name" value="Pyr_Knase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018209">
        <property type="entry name" value="Pyrv_Knase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015793">
        <property type="entry name" value="Pyrv_Knase_brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015795">
        <property type="entry name" value="Pyrv_Knase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036918">
        <property type="entry name" value="Pyrv_Knase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015806">
        <property type="entry name" value="Pyrv_Knase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004491">
        <property type="entry name" value="PRK05826.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004978">
        <property type="entry name" value="PRK06354.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01064">
        <property type="entry name" value="pyruv_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11817">
        <property type="entry name" value="PYRUVATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00224">
        <property type="entry name" value="PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02887">
        <property type="entry name" value="PK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01050">
        <property type="entry name" value="PYRUVTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52935">
        <property type="entry name" value="PK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00110">
        <property type="entry name" value="PYRUVATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13 15" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="9 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0630">Potassium</keyword>
    <keyword evidence="14" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate kinase barrel" evidence="16">
        <location>
            <begin position="36"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="Pyruvate kinase C-terminal" evidence="17">
        <location>
            <begin position="403"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAB0801929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="524" mass="56733" checksum="3CF7616FA1003C2F" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AXV8</accession>
    <name>A0A5N4AXV8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Single domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_04360</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AXV8"/>
    <dbReference type="FunCoup" id="A0A5N4AXV8">
        <property type="interactions" value="61"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AXV8"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029277">
        <property type="entry name" value="SVWC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053308">
        <property type="entry name" value="Vago-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39957">
        <property type="entry name" value="AT09846P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39957:SF1">
        <property type="entry name" value="AT09846P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15430">
        <property type="entry name" value="SVWC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01318">
        <property type="entry name" value="SVWC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Single" evidence="3">
        <location>
            <begin position="24"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0802174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="92" mass="10095" checksum="7920C8A074EDE4A2" modified="2020-02-26" version="1">MCLIVHGWTAREQVEMDPNDPDVCVHETIGRFRVGESKSLHPKQCIRATCERGMVSKAGCGTVLTKPPCHVGSTDLSKPYPDCCPKVICPKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AZ22</accession>
    <name>A0A5N4AZ22_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_04781</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AZ22"/>
    <dbReference type="InParanoid" id="A0A5N4AZ22"/>
    <dbReference type="OrthoDB" id="6775330at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34239">
        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34239:SF2">
        <property type="entry name" value="TRANSPOSABLE ELEMENT P TRANSPOSASE_THAP9 CONSERVED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="398"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0802595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="439" mass="49525" checksum="75A207BDF997BBA8" modified="2020-02-26" version="1">MGKNKKRARSNSSDSGDRVSSKKLMKRIKKLEIELKRQRSRSRSNSEGRHRRFRSRTPKPTSSTRSSQSRQCMPRSYSRSPAPKRVVSTRLRESTTTPNLSPDHQRSPRSWSRSPPPKHAAKAERSKEAAVYTEISNNNNKNACSIPSPVANNDMCSVVNSPDRDELQIFCDEELPTMSEDIFNSLGEDPNRVATNSFSLHEKLVTRWDALLTNGLKKGDSQTLLNNYELPSNLKSLCPPKLNLEVKAALQKQNILTDSAYVEIQNQLGKGLTALGKGISLLLDNLNKIPEDTRNPILTNLGDSGRILTNLFHRVSITRRNLLVPYLNKNVKDLTDNTLGSEFLFGSDLNEKLTSAKTLESISKELKLPTSFKSPVKKLTKLGGAKGQPLLRYQNQKPHFHYPARHSGETGPQKSLQAPRRYNNNYAPKKRDGERKKRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AZI8</accession>
    <name>A0A5N4AZI8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_04756</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AZI8"/>
    <dbReference type="InParanoid" id="A0A5N4AZI8"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049012">
        <property type="entry name" value="Mutator_transp_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31751">
        <property type="entry name" value="SI:CH211-108C17.2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31751:SF7">
        <property type="entry name" value="THAP-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20700">
        <property type="entry name" value="Mutator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0802570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="401" mass="44864" checksum="25191649E2E65CC2" modified="2020-02-26" version="1">MKESVPGYRIVQIDYFINKMLSMQKEHTSICTASKLLLKSEKRVGLVSEYTFECTSCVKLITISSENPKAPKVNKASVWGTLSTGGCYAHLQEFLSVLDIPSISNRLYYKYQAQLSENFESILAEDIQRAAQKEAELAKQFNEVDPDGIPAISVYADGRWSKRSYGHSYNALSGTAVIIGMRTKQVLYLGVKNKYCSICARAVNRNEPAKEHLCYKNHDGSATTMEADILVDGFKQSEHNGLRYKRLIGDGDTNVMAKIRTMVPYGSTVEKVECVNHCLKNFTKNLYAIKKNVKGVTLRARQLLSPDKIKRLAHSTRKVLALAASIGNARCRDLISQVVYCVFGSHENCVSEYCFNSDQKNNMQAEVLSTGLHHHIFAALSSVMAKIPQLVPFETMPQSYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B0N9</accession>
    <name>A0A5N4B0N9_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_00125</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B0N9"/>
    <dbReference type="InParanoid" id="A0A5N4B0N9"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0803155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="348" mass="40372" checksum="E637000EAB6C5302" modified="2020-02-26" version="1">MSTKNSCIEDFAILSKKITNVFPREQAATYYVAPIPKKMSGNKIHEKARGKLVDKQRNLLYMVKKLKSPKTNEIEADESYHQEVIDQEAKDSEIWLRRNTQPQCEVLQHWKQSYLARRNTQFQTIAQFLEQWPILRSPIAPDLINYDFAQVHKVPENFDLQTEFQNLFEAVLTQRKSSLSPADNTILQLLDTDDITSDSRRAIQLYLLASLVPPKGRTKVKKLHWKPSITEAREGVFVHVLTPGDIEQAKKQKINSMYSKGLTVQPYFIIIGPSLNNISQTLVIINQNTYQCNSILEALDFCFKSYIVLDAKYPFQSQHLWYLIQWIVYKYRAATDPKILFINDLVNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B0T6</accession>
    <name>A0A5N4B0T6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">V-type proton ATPase subunit C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_00179</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and two accessory subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the V-ATPase C subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B0T6"/>
    <dbReference type="InParanoid" id="A0A5N4B0T6"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14785">
        <property type="entry name" value="V-ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000002">
        <property type="entry name" value="V-type proton ATPase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1180">
        <property type="entry name" value="Vacuolar atp synthase subunit c, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004907">
        <property type="entry name" value="ATPase_V1-cplx_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036132">
        <property type="entry name" value="Vac_ATP_synth_c_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10137">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10137:SF0">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03223">
        <property type="entry name" value="V-ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118203">
        <property type="entry name" value="Vacuolar ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00071118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0803209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="298" mass="34264" checksum="087993E10743FC95" modified="2020-02-26" version="1">MLPSNDFTGDLPTYITRFQWDIAKYPTKQSLRNIADIISKQVGQIDADLKTKSTAYNNLKGNLQSLEKKQTGSLLTRNLADLVKKEHFILDSEYLTTLLVIVPKSQFHEWQTLYEKLTDMVVPRSSVLITQDQEYGLYTVSLFKKVADEYKLHAREKKFIVRDFTYNEEELAAGKNEITKLVTDKKKQFGPLVRWLKVNFSECFCAWIHVKALRVFVESVLRYGLPVNFQAILLHPSKKSVKRLRDVLNQLYGHLDSSALQASSGADSVDIPGLGFGQSEYYPYVYYKINIDMIDTKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B2R4</accession>
    <name>A0A5N4B2R4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_00857</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="6">Homodimer. Heterodimer with Jra. The kay-Jra heterodimer binds more stably to the AP-1 site than either of the two proteins alone.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bZIP family. Fos subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B2R4"/>
    <dbReference type="FunCoup" id="A0A5N4B2R4">
        <property type="interactions" value="335"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4B2R4"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14721">
        <property type="entry name" value="bZIP_Fos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000006">
        <property type="entry name" value="fos-related antigen 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000837">
        <property type="entry name" value="AP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004826">
        <property type="entry name" value="bZIP_Maf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23351">
        <property type="entry name" value="FOS TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23351:SF56">
        <property type="entry name" value="KAYAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03131">
        <property type="entry name" value="bZIP_Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00042">
        <property type="entry name" value="LEUZIPPRFOS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="8">
        <location>
            <begin position="166"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="121"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="10"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0803887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="385" mass="42218" checksum="D5C679D38B57AAF9" modified="2020-02-26" version="1">MKMDYSDGLSTNSDFSSDSQNSQTSSDFLTSSGNGLQINAASFITLEGLNSGVPTRTTPTLTPTTLRNIEQTFIELQSKPESHENEAGFVPPLVHAIGNNQYIPASEIDIYSKSSIWSNSQASTDLDSRPGSPVTPPKSGQQSEHTRRNMGGRKPVKDLNLTPEEEERRRVRRERNKMAAARCRKRRVDHTNALLNETDGLEQKKLAMQNELQELQAIKEELEFLLDSHRTSHCCRLQNGQQNDNPPSPPDIKPFVIPPYHQKVSTERVKTEIIDTSCIEIDADMFPFPAKKVMLSSTALPLVKPSRPSSLNVCSVKSSVSELAGISITTPSSGMQFNFDSLMVGGTGLTPISAPLVPSCSTQQRNIPTTHADISSPDTCGPPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B2R6</accession>
    <name>A0A5N4B2R6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_00826</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B2R6"/>
    <dbReference type="InParanoid" id="A0A5N4B2R6"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026103">
        <property type="entry name" value="HARBI1_animal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF85">
        <property type="entry name" value="GH03217P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02086">
        <property type="entry name" value="PUTNUCHARBI1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0803856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="159" mass="17634" checksum="233D09A78FAF62C9" modified="2020-02-26" version="1">MQRVTFEMVLKLIAPKILVKRARPGRPAIPAEKQLLITLWILGTPDSYRSVSDRFNASAIYCVRNVVGILNQLSNQFITWPTNEGMITSAAAFKAVSGFPGVIGAIDGTHISITAPKEHSESYVNRKGVHSIQLQVCFLFIETTFKLCFTGTFQKIYGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B3P3</accession>
    <name>A0A5N4B3P3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">BPTI/Kunitz inhibitor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PPYR_01182</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B3P3"/>
    <dbReference type="FunCoup" id="A0A5N4B3P3">
        <property type="interactions" value="36"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4B3P3"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.410.10:FF:000020">
        <property type="entry name" value="Collagen, type VI, alpha 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.10">
        <property type="entry name" value="Pancreatic trypsin inhibitor Kunitz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002223">
        <property type="entry name" value="Kunitz_BPTI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036880">
        <property type="entry name" value="Kunitz_BPTI_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020901">
        <property type="entry name" value="Prtase_inh_Kunz-CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050098">
        <property type="entry name" value="TFPI/VKTCI-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10083">
        <property type="entry name" value="KUNITZ-TYPE PROTEASE INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10083:SF376">
        <property type="entry name" value="SERINE PEPTIDASE INHIBITOR, KUNITZ TYPE, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00014">
        <property type="entry name" value="Kunitz_BPTI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00759">
        <property type="entry name" value="BASICPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00131">
        <property type="entry name" value="KU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57362">
        <property type="entry name" value="BPTI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00280">
        <property type="entry name" value="BPTI_KUNITZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50279">
        <property type="entry name" value="BPTI_KUNITZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1203">Blood coagulation cascade inhibiting toxin</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1199">Hemostasis impairing toxin</keyword>
    <keyword evidence="4" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0800">Toxin</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024380292" description="BPTI/Kunitz inhibitor domain-containing protein" evidence="9">
        <location>
            <begin position="21"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="10">
        <location>
            <begin position="33"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0804212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="98" mass="11007" checksum="BADC28754642B82F" modified="2020-02-26" version="1">MAHFTIVAIALCSICVASFAENEEILESRSYICNLPPTSGFCRARLYRWVYSPVMKKCVNFDYGGCAGNENNFETFEECMSFCSGNFIKPSVAYKNKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B3T0</accession>
    <name>A0A5N4B3T0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF4806 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_01173</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B3T0"/>
    <dbReference type="InParanoid" id="A0A5N4B3T0"/>
    <dbReference type="OrthoDB" id="10069532at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34153:SF2">
        <property type="entry name" value="SI:CH211-262H13.3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34153">
        <property type="entry name" value="SI:CH211-262H13.3-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0804203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="371" mass="41687" checksum="44E7F3A8B50A35B1" modified="2020-02-26" version="1">MAYVGIEFESDGENDAGEIAIVNKVWLTPMKRRVHWPSYSQPTKFESALRSGEEPGDTWMLYPVKRIFFETDNLLKARQKLKTAEVTSDVQSDTEFSEKRKRVPPPRLSYDSEEESVATLPRPPRFSLDKVNQQSSRQSYSQPEPRSSPSTHVNKKNCFRTIPSSPSSCADAIPSSPSSCADAINRQRLPTRSPLAVRGEERENLDSKVVVPLLLHIKEQNNQILSWIKKQSNTTVVHGTLPDDIPVKFPLCSIDSLTVLESYLMDDGHLAELAAYFSSLGGRDIGSKTNIILKNIFNNELAQLYSFYGSRGNKKAFNDLRVKTVIIRAVQLTTSNTTAEEISAHIKVWLKHAPQRLSNSLQPKKNCNQGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B433</accession>
    <name>A0A5N4B433_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Alpha-2-macroglobulin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PPYR_01283</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4B433"/>
    <dbReference type="OrthoDB" id="9998011at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004866">
        <property type="term" value="F:endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02897">
        <property type="entry name" value="A2M_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.130.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1930">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.690">
        <property type="entry name" value="Alpha-macroglobulin, receptor-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009048">
        <property type="entry name" value="A-macroglobulin_rcpt-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036595">
        <property type="entry name" value="A-macroglobulin_rcpt-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050473">
        <property type="entry name" value="A2M/Complement_sys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011625">
        <property type="entry name" value="A2M_N_BRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041813">
        <property type="entry name" value="A2M_TED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047565">
        <property type="entry name" value="Alpha-macroglob_thiol-ester_cl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011626">
        <property type="entry name" value="Alpha-macroglobulin_TED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001599">
        <property type="entry name" value="Macroglobln_a2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019742">
        <property type="entry name" value="MacrogloblnA2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002890">
        <property type="entry name" value="MG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041555">
        <property type="entry name" value="MG3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412">
        <property type="entry name" value="MACROGLOBULIN / COMPLEMENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412:SF171">
        <property type="entry name" value="PREGNANCY ZONE PROTEIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00207">
        <property type="entry name" value="A2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07703">
        <property type="entry name" value="A2M_BRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07677">
        <property type="entry name" value="A2M_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01835">
        <property type="entry name" value="MG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17791">
        <property type="entry name" value="MG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07678">
        <property type="entry name" value="TED_complement"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01360">
        <property type="entry name" value="A2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01359">
        <property type="entry name" value="A2M_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01361">
        <property type="entry name" value="A2M_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01419">
        <property type="entry name" value="Thiol-ester_cl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49410">
        <property type="entry name" value="Alpha-macroglobulin receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00477">
        <property type="entry name" value="ALPHA_2_MACROGLOBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024369748" description="Alpha-2-macroglobulin domain-containing protein" evidence="4">
        <location>
            <begin position="26"/>
            <end position="1557"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-2-macroglobulin bait region" evidence="5">
        <location>
            <begin position="467"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-2-macroglobulin" evidence="6">
        <location>
            <begin position="774"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-macroglobulin receptor-binding" evidence="7">
        <location>
            <begin position="1382"/>
            <end position="1471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0804313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1557" mass="175594" checksum="ADF7EA38439FE68A" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B484</accession>
    <name>A0A5N4B484_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_01346</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the liprin family. Liprin-alpha subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B484"/>
    <dbReference type="FunCoup" id="A0A5N4B484">
        <property type="interactions" value="551"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4B484"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048786">
        <property type="term" value="C:presynaptic active zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050808">
        <property type="term" value="P:synapse organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09562">
        <property type="entry name" value="SAM_liprin-alpha1_2_3_4_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09565">
        <property type="entry name" value="SAM_liprin-alpha1_2_3_4_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09568">
        <property type="entry name" value="SAM_liprin-alpha1_2_3_4_repeat3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000002">
        <property type="entry name" value="PTPRF interacting protein alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000004">
        <property type="entry name" value="PTPRF interacting protein alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057892">
        <property type="entry name" value="LIP-1_CC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037620">
        <property type="entry name" value="LIP-1_SAM_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037621">
        <property type="entry name" value="LIP-1_SAM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037622">
        <property type="entry name" value="LIP-1_SAM_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029515">
        <property type="entry name" value="Liprin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12587">
        <property type="entry name" value="LAR INTERACTING PROTEIN LIP -RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12587:SF20">
        <property type="entry name" value="LIPRIN-ALPHA, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25526">
        <property type="entry name" value="LIP-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="SAM" evidence="6">
        <location>
            <begin position="904"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="6">
        <location>
            <begin position="997"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="6">
        <location>
            <begin position="1077"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="483"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="634"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="681"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="742"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="28"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="120"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="206"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="420"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="588"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="156"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="483"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="681"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="765"/>
            <end position="782"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0804376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1158" mass="130508" checksum="84284EC5DE7035A9" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2024-03-27" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B4I5</accession>
    <name>A0A5N4B4I5_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_01433</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B4I5"/>
    <dbReference type="InParanoid" id="A0A5N4B4I5"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31912">
        <property type="entry name" value="IP13529P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31912:SF34">
        <property type="entry name" value="NOTOCHORD-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0804463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="344" mass="40100" checksum="D642D55DCDAFE7DE" modified="2020-02-26" version="1">MHDILEGILRYEMAYLIDHLLTKKYFTLDNLNNRICYFNFAAVDIGNPLYLIMSASQMLGFFSYFGILIADLVPEKDSCWELYTILYQIIDILLSRIISKQTIEYLEILIVEHHRLYCELFDQTLKPKHHFMIHYPTVILNLGPLRHIWSMRYEAFHKVLKSTANSVTSRKNILLTLATKQQLRLSYRFLSRQGFNDNITCGNFEDLASLKDFFILKQLLEKNQIEIDNLFHTSWLKVNSFEYKLGYASQINNDEETDLPSDLPQFGTIKYILGNKMQNIFFLIIQPLHLIGLNTHIGGYEVLDSMSTHDSINLIVMPIDRLPNHLCHNIHTMANGTKVICALQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B4S2</accession>
    <name>A0A5N4B4S2_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_01562</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B4S2"/>
    <dbReference type="InParanoid" id="A0A5N4B4S2"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38681:SF1">
        <property type="entry name" value="RETROVIRUS-RELATED POL POLYPROTEIN FROM TRANSPOSON 412-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38681">
        <property type="entry name" value="RETROVIRUS-RELATED POL POLYPROTEIN FROM TRANSPOSON 412-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0804592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="134" mass="14962" checksum="6C5D33E5CB4E7DD2" modified="2020-02-26" version="1">MQSMKPTPASNHNTQKSTFQLKDIDTATHVYIRVDAAKRPLQAPYEGPYPVVTRNDKTTTIRRHGTDITVSNDRVKPAYQERDEEQADTSKVVPPSPAPLAKRPVGRPPKLSIPPAEAQTAKRPNYATLREFTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B5K7</accession>
    <name>A0A5N4B5K7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Dynein axonemal assembly factor 1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PPYR_01859</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Cilium-specific protein required for cilia structures.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Cilium</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DNAAF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B5K7"/>
    <dbReference type="InParanoid" id="A0A5N4B5K7"/>
    <dbReference type="OrthoDB" id="6334211at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050576">
        <property type="entry name" value="Cilia_flagella_integrity"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45973:SF9">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45973">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT SDS22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Guanylate kinase-like" evidence="10">
        <location>
            <begin position="419"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="23"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0804889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="882" mass="99195" checksum="ECED7E8CBEAA9C31" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B6C2</accession>
    <name>A0A5N4B6C2_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DDB1- and CUL4-associated factor 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_02074</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0805104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B6C2"/>
    <dbReference type="FunCoup" id="A0A5N4B6C2">
        <property type="interactions" value="509"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4B6C2"/>
    <dbReference type="OrthoDB" id="63070at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000492">
        <property type="entry name" value="LEC14B homolog isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051859">
        <property type="entry name" value="DCAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19847">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19847:SF7">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="277"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="325"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="454"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0805104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="541" mass="61457" checksum="9A1E4B306CA960E3" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B6R4</accession>
    <name>A0A5N4B6R4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PPYR_00084</name>
        <name evidence="11" type="ORF">PPYR_02271</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0805301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B6R4"/>
    <dbReference type="InParanoid" id="A0A5N4B6R4"/>
    <dbReference type="OrthoDB" id="6582319at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF269">
        <property type="entry name" value="NUCLEASE HARBI1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="domain" description="DDE Tnp4" evidence="9">
        <location>
            <begin position="173"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0803114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0805301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="430" mass="49283" checksum="DC0FCC5BACA7135F" modified="2020-02-26" version="1">MMDDDEVFAAFLLLTTAAMLYLKRKKRVRRYKVRPINRNRIVHGQFHKRVRRMREMDHEQYFKYTRMTPAVFDNLLSIVGPHLQRHKKKSHISPAERLTLTLHYLAEGCSMQEIATNFYMGKTTVHIIIKQTCSVLWDVLSPIHLKPPTGTEFVKISKGFYQRWNMPNCLGALDGKHIQIQAPAHSGSDFFNYKKTSSIVLMAACDAFYRFTLVDVGGYGSQHDSIVFSESAFGQAILKNQNDVLDLPDAKQLPGTSVSLPFFFVADQAFPLHKRIMRPYPGERLGENKEIFNYRLSRARRTIENTFGILSARWRIFRRPIVANVTTCEAIVKACVVLHNFLQVKEEDIPMGSRKYCPTGFGDEVDINGGLRPGQWRNESNMLRPVGRLGSNFSTRIVRQNRELLTAYFASAQGKVSWQYDHIAEGSLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B759</accession>
    <name>A0A5N4B759_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Putative nuclease HARBI1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Harbinger transposase-derived nuclease</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PPYR_02364</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Transposase-derived protein that may have nuclease activity. Does not have transposase activity.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HARBI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0805394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B759"/>
    <dbReference type="InParanoid" id="A0A5N4B759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026103">
        <property type="entry name" value="HARBI1_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF85">
        <property type="entry name" value="GH03217P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02086">
        <property type="entry name" value="PUTNUCHARBI1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="13">
        <location>
            <begin position="107"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAB0805394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="212" mass="24114" checksum="4237DB17ACA8EEAE" modified="2020-02-26" version="1">MSKSTFEYLVNIIRGDLIRKVNGCPTIPAEKQLMIALWKMATSDSYRSVCDRFNVGKATGLRAVRRVTYSLHKRAARWIQWPVGDRAITVMQQFEASSGFPRVIGAIDGTHIRIDAPQENAPDYVNRKHFHSIQLQLVCDSNMLITHCYTGHPGSVHDQRVFRLSDVANFVEDAEKFPMDSHLLGDAAYELHEHLLVPFRDNGHLDRTAKQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B799</accession>
    <name>A0A5N4B799_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_02416</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0805446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B799"/>
    <dbReference type="InParanoid" id="A0A5N4B799"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511">
        <property type="entry name" value="PROTEIN CBG23764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511:SF12">
        <property type="entry name" value="RHO TERMINATION FACTOR N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="391"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0805446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1089" mass="124629" checksum="131FDC0F795FFAC5" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B7K8</accession>
    <name>A0A5N4B7K8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_02559</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0805589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B7K8"/>
    <dbReference type="InParanoid" id="A0A5N4B7K8"/>
    <dbReference type="OrthoDB" id="6776240at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051487">
        <property type="entry name" value="Ser/Thr_Proteases_Immune/Dev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24256">
        <property type="entry name" value="TRYPTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S1" evidence="3">
        <location>
            <begin position="1"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0805589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="269" mass="30426" checksum="5B23DA52103794D2" modified="2020-02-26" version="1">MMAIYQRVKEVEIMVCGGTLIKPKWVLTSNTCYKKLSVYANGSWPFMVARVHNLAAVSVSPKREINMVISHSEYKDVNYTVANDIALMATDTEFLVNSYIFPITLASTHLISDSNCSFVYWNVSMPYRFNREAAPLVKVRVLVKDINNCKQWFNYTLVYSYGQICAQLSHGVIPKQHSGGPLVCNNTQVGLFSSQQESNGETFLIFTELQPYRKFISDVIPALRLSEMEEGATKRKFSVMFNPANSCWALHETILLTLVISLSNNLQHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B7U5</accession>
    <name>A0A5N4B7U5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">allantoinase</fullName>
            <ecNumber evidence="6">3.5.2.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PPYR_02604</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(S)-allantoin + H2O = allantoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17029"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15678"/>
            <dbReference type="ChEBI" id="CHEBI:17536"/>
            <dbReference type="EC" id="3.5.2.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Nitrogen metabolism; (S)-allantoin degradation; allantoate from (S)-allantoin: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-dependent hydrolases superfamily. Allantoinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.5" evidence="6"/>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0805634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B7U5"/>
    <dbReference type="FunCoup" id="A0A5N4B7U5">
        <property type="interactions" value="105"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4B7U5"/>
    <dbReference type="UniPathway" id="UPA00395">
        <property type="reaction ID" value="UER00653"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004038">
        <property type="term" value="F:allantoinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050897">
        <property type="term" value="F:cobalt ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000256">
        <property type="term" value="P:allantoin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006145">
        <property type="term" value="P:purine nucleobase catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000032">
        <property type="entry name" value="Allantoinase Dal1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017593">
        <property type="entry name" value="Allantoinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050138">
        <property type="entry name" value="DHOase/Allantoinase_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002195">
        <property type="entry name" value="Dihydroorotase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03178">
        <property type="entry name" value="allantoinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43668">
        <property type="entry name" value="ALLANTOINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43668:SF2">
        <property type="entry name" value="ALLANTOINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00482">
        <property type="entry name" value="DIHYDROOROTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="10">
        <location>
            <begin position="58"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0805634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="474" mass="52665" checksum="B218D9432BE45CAC" modified="2020-02-26" version="1">MEPNKLFISENIIVDNKFLNGGILVNNAGKITKVLRHHEIAPYKKCQNVEIIDVGTHVIMPGIVDSHVHVNEPGRTDWEGYETATRAAAAGGVTTIVDMPLNSIPPTTTLHNFKQKLKAAQGKVYVDVAFWGGVIPGNQDDLMDLINAGVVGFKCFMCESGVEEFPCVNKEQIEVAMKILENTDSVLAFHAELDGNGSAASNDDSCQYSTFLRTRPASMEINAIKLIIELARNYNVRVHIVHLSTADALPIIAEAKKDGVKLTVETCHHYLSIKNEDIPEKATQFKCTPPIRDLTNLNLLWQAIKNGLLDMVVSDHSPCTSDLKCLESGNFMQAWGGISSLQFGNKNIVKLGFALVLIDLSLFWTQVKQHGLSIFDINKYMTYMPAKLVGLHNVKGQIATNYDADFVIWDPHSIIHVEPEMIQHKNKITPYLGKNLYGKVLKTVVRGHVVYDNEKFVNKPNGKLIQNVIKDEII</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1JW39</accession>
    <name>A0A1Y1JW39_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_07264</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01099054">
        <property type="protein sequence ID" value="JAV53529.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1JW39"/>
    <dbReference type="FunCoup" id="A0A1Y1JW39">
        <property type="interactions" value="256"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1JW39"/>
    <dbReference type="OrthoDB" id="19690at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43601:SF5">
        <property type="entry name" value="EG:132E8.3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43601">
        <property type="entry name" value="THIOREDOXIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="22"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="JAV53529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0799384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="148" mass="16581" checksum="7B8851FE116BCC81" modified="2017-08-30" version="1">MMLTHLKSSLQGNRSLVTLFKTVTHDKANLRKICSSLKLNKIITIMNDDDFMSKVMNSDNPVIVNFHAEWCEPCHILTPKMKQLIEPKDNIDLAIVDVESHAELVHTFEVKAVPAVIAVKNGLVVDKFIGLVDANMIESLISKLDKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1JWY2</accession>
    <name>A0A1Y1JWY2_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">4'-phosphopantetheine phosphatase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Inactive pantothenic acid kinase 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PPYR_09243</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Phosphatase which shows a preference for 4'-phosphopantetheine and its oxidatively damaged forms (sulfonate or S-sulfonate), providing strong indirect evidence that the phosphatase activity pre-empts damage in the coenzyme A (CoA) pathway. Hydrolyzing excess 4'-phosphopantetheine could constitute a directed overflow mechanism to prevent its oxidation to the S-sulfonate, sulfonate, or other forms. Hydrolyzing 4'-phosphopantetheine sulfonate or S-sulfonate would forestall their conversion to inactive forms of CoA and acyl carrier protein. May play a role in the physiological regulation of CoA intracellular levels.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(R)-4'-phospho-S-sulfopantetheine + H2O = (R)-S-sulfopantetheine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:68340"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:177302"/>
            <dbReference type="ChEBI" id="CHEBI:177303"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:68341"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer. Interacts with PKM.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01101781">
        <property type="protein sequence ID" value="JAV52300.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1JWY2"/>
    <dbReference type="FunCoup" id="A0A1Y1JWY2">
        <property type="interactions" value="646"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1JWY2"/>
    <dbReference type="OrthoDB" id="498611at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004594">
        <property type="term" value="F:pantothenate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10880">
        <property type="entry name" value="Uncharacterised protein PF01937, DUF89, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036075">
        <property type="entry name" value="ARMT-1-like_metal-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002791">
        <property type="entry name" value="ARMT1-like_metal-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004567">
        <property type="entry name" value="Type_II_PanK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12280:SF35">
        <property type="entry name" value="4'-PHOSPHOPANTETHEINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12280">
        <property type="entry name" value="PANTOTHENATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01937">
        <property type="entry name" value="ARMT1-like_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111321">
        <property type="entry name" value="AF1104-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0533">Nickel</keyword>
    <keyword evidence="5" id="KW-0944">Nitration</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Damage-control phosphatase ARMT1-like metal-binding" evidence="9">
        <location>
            <begin position="43"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="JAV52300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0798250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="363" mass="41729" checksum="4C1E60E56E2796B8" modified="2017-08-30" version="1">MMKDKKIVCPLLLDKETYLPDTIDLLNDKEAISYWLPCLEEMARNFVNKVSYLCPHDKTATERAKYTWQKFHDFIEQIKYNPQQFKPLSIRTLLEFNEENLRKSNFDDPWLLQKQKETVAAFTQYQDRVNFVDSIEDFYLKWEELSKGLVAGNLFDWGAKAIADILEECNGFGLTHAMQKIQQRPWFHDDLDKWISKLKRTPYVKAVVFIDNAGVDFVLGVLPLTRELLKQGTSVVLTANSGPALNDVTYSDLEVYLKSAEQKCDVLRDAIANNRLMAIENGQKGPCLDLRTLHNELCAEMQTADLLILEGMGRAVHTNLKAKFKVDCLKLAVLKNEWLAKNLGAQQFSVIFQYDPAPLPKVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1K1B8</accession>
    <name>A0A1Y1K1B8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nuclear protein localization protein 4 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PPYR_12840</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="5">Protein degradation; proteasomal ubiquitin-dependent pathway.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NPL4 family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01095937">
        <property type="protein sequence ID" value="JAV55244.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01095936">
        <property type="protein sequence ID" value="JAV55245.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1K1B8"/>
    <dbReference type="FunCoup" id="A0A1Y1K1B8">
        <property type="interactions" value="2618"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1K1B8"/>
    <dbReference type="OrthoDB" id="10251089at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08061">
        <property type="entry name" value="MPN_NPL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000012">
        <property type="entry name" value="nuclear protein localization protein 4 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
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    <evidence type="ECO:0000256" key="8">
        <source>
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            <dbReference type="PROSITE" id="PS50199"/>
        </source>
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        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="JAV55244.1"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAB0793220.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="634" mass="71055" checksum="CDCA5C32E73D83A7" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1K7E3</accession>
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        <recommendedName>
            <fullName evidence="11">Hexosyltransferase</fullName>
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    </protein>
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        <name evidence="13" type="ORF">PPYR_05636</name>
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    <organism evidence="12">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
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            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
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            <taxon>Elateroidea</taxon>
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            <taxon>Lampyrinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
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                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
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        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
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        <subcellularLocation>
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    </dbReference>
    <dbReference type="GO" id="GO:0000139">
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HEXOSYLTRANSFERASE-RELATED"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
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</entry>
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        <recommendedName>
            <fullName evidence="6">Kinetochore protein SPC25</fullName>
        </recommendedName>
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        <name evidence="4" type="ORF">PPYR_08826</name>
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        <name type="scientific">Photinus pyralis</name>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
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            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
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                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01083039">
        <property type="protein sequence ID" value="JAV61203.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1KID2"/>
    <dbReference type="InParanoid" id="A0A1Y1KID2"/>
    <dbReference type="OrthoDB" id="6810166at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="82"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="JAV61203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0797746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0797833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="234" mass="27022" checksum="238A4ABA8024BD22" modified="2017-08-30" version="1">MSDHFLENVDEIHNHVAVLEHNLNAIQDYKEQFIDAVNDKIGLTSSDLENGRTAAVNVKESSKIDNECQELDEEICGLLNQIQVKEENIRNLTQQLQHKKEALEKLKLEEEAAHINNQTKLKGFQKALHHFTQNFQYTISLEDVEDPNRYHLIMTFIIDKVVSPYPIKFIFENKTDILIDFDGRALLTDDEHRTLSDLYHKRKNTLALLCRLRNITKKRMLQAKSGALGNEGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1KJA0</accession>
    <name>A0A1Y1KJA0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">GB1/RHD3-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PPYR_01962</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">1611_PpyrPB1</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">1611_PpyrPB1</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01087174">
        <property type="protein sequence ID" value="JAV58867.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1KJA0"/>
    <dbReference type="FunCoup" id="A0A1Y1KJA0">
        <property type="interactions" value="1453"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1KJA0"/>
    <dbReference type="OrthoDB" id="7788754at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01851">
        <property type="entry name" value="GBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003207">
        <property type="entry name" value="ATLastiN (Endoplasmic reticulum GTPase) related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:004169">
        <property type="entry name" value="Atlastin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.420:FF:000001">
        <property type="entry name" value="Atlastin-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.420">
        <property type="entry name" value="AHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030386">
        <property type="entry name" value="G_GB1_RHD3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003191">
        <property type="entry name" value="Guanylate-bd/ATL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036543">
        <property type="entry name" value="Guanylate-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015894">
        <property type="entry name" value="Guanylate-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10751">
        <property type="entry name" value="GUANYLATE BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02263">
        <property type="entry name" value="GBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02841">
        <property type="entry name" value="GBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48340">
        <property type="entry name" value="Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51715">
        <property type="entry name" value="G_GB1_RHD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="453"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="480"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="GB1/RHD3-type G" evidence="14">
        <location>
            <begin position="63"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="JAV58867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAB0804992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="560" mass="63612" checksum="E4684FDCAED6D6C5" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1KN37</accession>
    <name>A0A1Y1KN37_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">N-acetylneuraminate lyase</fullName>
            <ecNumber evidence="5">4.1.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PPYR_01313</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>aceneuramate = aldehydo-N-acetyl-D-mannosamine + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:23296"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:17122"/>
            <dbReference type="ChEBI" id="CHEBI:173083"/>
            <dbReference type="EC" id="4.1.3.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-sugar metabolism; N-acetylneuraminate degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DapA family. NanA subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.3" evidence="5"/>
    <dbReference type="EMBL" id="GEZM01081090">
        <property type="protein sequence ID" value="JAV61891.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1KN37"/>
    <dbReference type="InParanoid" id="A0A1Y1KN37"/>
    <dbReference type="OrthoDB" id="191315at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008747">
        <property type="term" value="F:N-acetylneuraminate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048325">
        <property type="entry name" value="ZSWIM3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="DIHYDRODIPICOLINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128:SF21">
        <property type="entry name" value="N-ACETYLNEURAMINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21599">
        <property type="entry name" value="ZSWIM3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0704">Schiff base</keyword>
    <feature type="domain" description="ZSWIM3 N-terminal" evidence="11">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004878"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
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    <sequence length="464" mass="51797" checksum="6C822D6F6AEEB610" modified="2017-08-30" version="1">MEIGVRFPSYHLLMHHLEEFTKETQCKFWKRDARTIGAARSLGVTKHLNPDLIYFELKFSCVYGGVDFKTKGRNIRPRQPSLKTNGCPVFLRFKASEDGEALQLVAKNLNHNHELKLPTKKKVTSEFELSESETKRSKWENMNDTERDTYDQDDDDLKEEIVKYEGLIAPVYTPFNNDPTRSLNLEILPSYAQYLIDNGITGILINGTAGEGTVMTVEERKLVAEVWAQLCSQGQLHLMVHVGGVPLPDVLELAQHAEHIGANSILCLPELFHKPATCDDLIRYLQLVSQAAPNTPLFYYHIPSYSGVNLHMGEFLNKVQGSIPTLSGIKFTSTVLDEGYAALKACNERFTVFLGSDTVMAGAYALGFESAIATTLNMLPQFGQQIVQCIKDGNIKEAQEKQNDLNSALEIIAKHGAWVPSTKMAMNLLSPIDVGPTREPIKTLTAEEAKQMENELTSLSFITS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Photinus pyralis</name>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
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                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
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            <dbReference type="DOI" id="10.1038/srep38556"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </reference>
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        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
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</entry>
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    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
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                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
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                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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        <subcellularLocation>
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            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the inturned family.</text>
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    </dbReference>
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        <source>
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        </source>
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        <source>
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        <source>
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01060706">
        <property type="protein sequence ID" value="JAV70951.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0794704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1LDJ0"/>
    <dbReference type="FunCoup" id="A0A1Y1LDJ0">
        <property type="interactions" value="568"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1LDJ0"/>
    <dbReference type="OrthoDB" id="424974at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.9.10:FF:000026">
        <property type="entry name" value="FAD-dependent oxidoreductase domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF282">
        <property type="entry name" value="LETHAL (2) 37BB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="1">
        <location>
            <begin position="68"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="JAV70951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0794704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="483" mass="53821" checksum="9675FF9D14712FD7" modified="2017-08-30" version="1">MISRQLYKLCKTIVRTNRAVHTSAIHFEEPEHPFKRTVRILTDDVRNFLKSPLRGFSPPSDIFPRHADILIIGGGAVGSSIAYFLKEKTGLRGVNIVVIEKDTTYSKCSTVLSVGGLRQQFSLPENIQMSLFGAEFLRSVKKRFGPDSDVYFTPNGYLMLATEHGAQQLIDNSKIQTELGAVNKVLSKRELKERFPWMEVEDVEAGCLGLEKEGWFDPWALLGMLKRGATNMGTQYINAEAVGFNFEDQQDVIVDGQLTGTYQRLDSVDVKLPDGEVKTIQFAYCVIAAGAESGELAKLAKIGNGEGMLTVPLPVERRKRYVYCFECQEHGPGLNTPMTIDYTGAYFRRDGLGGAFIAGLSPQPEEEPPTTNLEVDHEFFNSRLWPLLAQRVPAFNALKVRSSWAGYYDYNMFDENGIIGAHPYLFNLYIATGFSGHGIQQAPAVGRAVAELIIDGGFQTIDLTRLGFDRLLIDKPMYEVCIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LFL8</accession>
    <name>A0A1Y1LFL8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Multidrug resistance-associated protein lethal(2)03659</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PPYR_08864</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01061568">
        <property type="protein sequence ID" value="JAV70366.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1LFL8"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18579">
        <property type="entry name" value="ABC_6TM_ABCC_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000026">
        <property type="entry name" value="Multidrug resistance-associated protein lethal(2)03659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000014">
        <property type="entry name" value="Multidrug resistance-associated protein member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000163">
        <property type="entry name" value="Multidrug resistance-associated protein member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000482">
        <property type="entry name" value="Multidrug resistance-associated protein member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044746">
        <property type="entry name" value="ABCC_6TM_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF456">
        <property type="entry name" value="MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN LETHAL(2)03659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="317"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="346"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="705"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="776"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="857"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="949"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="94"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="414"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="780"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="1053"/>
            <end position="1285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="JAV70366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAB0797871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1313" mass="147780" checksum="9B81354D3AA4A6A6" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LKP1</accession>
    <name>A0A1Y1LKP1_PHOPY</name>
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        <recommendedName>
            <fullName evidence="14">SLIT-ROBO Rho GTPase-activating protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PPYR_05390</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01059008">
        <property type="protein sequence ID" value="JAV71577.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000003">
        <property type="protein sequence ID" value="KAB0801036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1LKP1"/>
    <dbReference type="InParanoid" id="A0A1Y1LKP1"/>
    <dbReference type="OrthoDB" id="5981864at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07656">
        <property type="entry name" value="F-BAR_srGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04383">
        <property type="entry name" value="RhoGAP_srGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11809">
        <property type="entry name" value="SH3_srGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.555.10:FF:000026">
        <property type="entry name" value="Rho GTPase activating protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000136">
        <property type="entry name" value="Rho GTPase activating protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000094">
        <property type="entry name" value="SLIT-ROBO Rho GTPase-activating 2 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031160">
        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051627">
        <property type="entry name" value="SLIT-ROBO_RhoGAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14166">
        <property type="entry name" value="SLIT-ROBO RHO GTPASE ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00611">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00055">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51741">
        <property type="entry name" value="F_BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5 6" id="KW-0175">Coiled coil</keyword>
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    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0728">SH3 domain</keyword>
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        <location>
            <begin position="21"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="9">
        <location>
            <begin position="488"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="8">
        <location>
            <begin position="720"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="690"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="787"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="982"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1045"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="168"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="695"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="708"/>
            <end position="720"/>
        </location>
    </feature>
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        <location>
            <begin position="986"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1088"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1102"/>
            <end position="1111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="JAV71577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAB0801036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1111" mass="127494" checksum="08B58B176D73707E" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LKZ9</accession>
    <name>A0A1Y1LKZ9_PHOPY</name>
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        <recommendedName>
            <fullName evidence="9">Cullin-5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PPYR_05127</name>
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    <organism evidence="13">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10 11">Belongs to the cullin family.</text>
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        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01055618">
        <property type="protein sequence ID" value="JAV73001.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000002">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="InParanoid" id="A0A1Y1LKZ9"/>
    <dbReference type="OrthoDB" id="27073at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031461">
        <property type="term" value="C:cullin-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000009">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000014">
        <property type="entry name" value="Cullin 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000017">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.130:FF:000004">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01256">
        <property type="entry name" value="CULLIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Cullin family profile" evidence="12">
        <location>
            <begin position="402"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="JAV73000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAB0802941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="773" mass="89690" checksum="283BD94535FD9C9F" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LR40</accession>
    <name>A0A1Y1LR40_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">5'-Nucleotidase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PPYR_02170</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the 5'-nucleotidase family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01049101">
        <property type="protein sequence ID" value="JAV76103.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0805200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1LR40"/>
    <dbReference type="FunCoup" id="A0A1Y1LR40">
        <property type="interactions" value="137"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1LR40"/>
    <dbReference type="OrthoDB" id="10252235at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07406">
        <property type="entry name" value="MPP_CG11883_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.780.10">
        <property type="entry name" value="5'-Nucleotidase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008334">
        <property type="entry name" value="5'-Nucleotdase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036907">
        <property type="entry name" value="5'-Nucleotdase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041821">
        <property type="entry name" value="CG11883_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575:SF48">
        <property type="entry name" value="5'-NUCLEOTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="5'-NUCLEOTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02872">
        <property type="entry name" value="5_nucleotid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01607">
        <property type="entry name" value="APYRASEFAMLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55816">
        <property type="entry name" value="5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain"/>
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    </dbReference>
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        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="5">
        <location>
            <begin position="68"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="5'-Nucleotidase C-terminal" evidence="6">
        <location>
            <begin position="353"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="555"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="571"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="JAV76103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0805200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="647" mass="71792" checksum="F9CF08CB0810AB2F" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LWH2</accession>
    <name>A0A1Y1LWH2_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Protein krueppel</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PPYR_10560</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">1611_PpyrPB1</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">1611_PpyrPB1</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GEZM01045172">
        <property type="protein sequence ID" value="JAV77882.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1LWH2"/>
    <dbReference type="InParanoid" id="A0A1Y1LWH2"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000097">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
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    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="6"/>
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        </location>
    </feature>
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        <location>
            <position position="8"/>
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        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
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        <location>
            <position position="11"/>
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        <ligand>
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        </location>
        <ligand>
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            <position position="56"/>
        </location>
        <ligand>
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            <dbReference type="ARBA" id="ARBA00003767"/>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="PROSITE" id="PS51915"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAB0796499.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="407" mass="47173" checksum="CC9CA096F33154B8" modified="2017-08-30" version="1">MLGTLKMCYTCLEIKDDELIDVTALDFDSRTFLYKLQMCVSSHLDEHNSKLLCSECVKQLRVSYKFRATVLLSQDILNKRKNDLLPTVYEGDPTDVLYKIAVHRQFFGSQCLIVNDPVDLNDLRETDKNKAPELPSNEAAYFLELKSESAAQVDDIHNSQFTIADLINKFECSKCNIVADSEHHDCSKYNGGYKSAKEIKVKRRRVRVKRELAVLEDDITYECYHCATVFNKRWKLQKHITRVHTNVKKHICPYCAKSFKQSYHLREHLTSHTGERNYTCSYCEKTFQRISSLKRHSRSHERAPGEKTKKTPFLCTVCGKNFPFSNGVQRHMRTHLGIRNHECTVCHRRFTQSTHLHVHMRTHTGEKPYICDTCGEAFPLNASLQKHMAIHKSNSDCDQLKMSPNCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LXK8</accession>
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        <name evidence="4" type="ORF">PPYR_10631</name>
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        <name type="common">Common eastern firefly</name>
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        <lineage>
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            <taxon>Pterygota</taxon>
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            <taxon>Coleoptera</taxon>
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    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
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                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
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        <property type="protein sequence ID" value="JAV76386.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
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        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
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        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
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        <property type="molecule type" value="Transcribed_RNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="P:hemocyte migration"/>
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        <property type="project" value="TreeGrafter"/>
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        </location>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="JAV76386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0796570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="142" mass="16161" checksum="BB34D849568EDA5A" modified="2017-08-30" version="1">MGVYKVIWYTLLEFLLLQLVKVNCAEDVDAWRLHERTVGGFSCGPPQPRSFRLDEIMDDDELPDIQTHVFPKMTVLYRCDSHSGCCQSRTKQCAPQVLEEVRLTFRLLGHAGKGSLLKEKYINVATTNHTRCSCQTVTGNIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1M0G7</accession>
    <name>A0A1Y1M0G7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transcription cofactor vestigial-like protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_11979</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Photinus pyralis</name>
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            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
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                <person name="Al-Wathiqui N."/>
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            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01045505">
        <property type="protein sequence ID" value="JAV77774.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01045504">
        <property type="protein sequence ID" value="JAV77775.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0795140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1M0G7"/>
    <dbReference type="InParanoid" id="A0A1Y1M0G7"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001223">
        <property type="term" value="F:transcription coactivator binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="TDU_repeat"/>
    </dbReference>
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        <property type="entry name" value="VGLL4"/>
    </dbReference>
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        <property type="entry name" value="TONDU-DOMAIN-CONTAINING GROWTH INHIBITOR, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TRANSCRIPTION COFACTOR VESTIGIAL-LIKE PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15245">
        <property type="entry name" value="VGLL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00711">
        <property type="entry name" value="TDU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="JAV77775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0795140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="207" mass="23376" checksum="524BA78E3C012A31" modified="2017-08-30" version="1">MDVGESPLDVLSRVAEIQQAITISEDSNKHASTKQLPTTKWKRDRRTRPEYSRKSDPKMPEEFELPPNGGIDTPLDMSVRQRGQPPSYSQTINNPEFRSSYRTSVITQAQRDDMPSGISMCDPIIDEHFRRSLGKDYVKIFSNNNAPPKDPPIVKSPPKIKDKVMELMDSTGLSVDDHFAKALGDTWLKLNKKEECDSSEKEAVISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1M1H9</accession>
    <name>A0A1Y1M1H9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Polypeptide N-acetylgalactosaminyltransferase</fullName>
            <ecNumber evidence="16">2.4.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Protein-UDP acetylgalactosaminyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PPYR_07164</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="19 20" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">1611_PpyrPB1</strain>
            <tissue evidence="19">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">1611_PpyrPB1</strain>
            <tissue evidence="19">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 16">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 16">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 16">Golgi apparatus membrane</location>
            <topology evidence="2 16">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="16"/>
    <dbReference type="EMBL" id="GEZM01045605">
        <property type="protein sequence ID" value="JAV77726.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1M1H9"/>
    <dbReference type="FunCoup" id="A0A1Y1M1H9">
        <property type="interactions" value="309"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1M1H9"/>
    <dbReference type="OrthoDB" id="416652at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004653">
        <property type="term" value="F:polypeptide N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23459">
        <property type="entry name" value="beta-trefoil_Ricin_Pgant1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02510">
        <property type="entry name" value="pp-GalNAc-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000021">
        <property type="entry name" value="Polypeptide N-acetylgalactosaminyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045885">
        <property type="entry name" value="GalNAc-T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675">
        <property type="entry name" value="N-ACETYLGALACTOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675:SF43">
        <property type="entry name" value="POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 16" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12 16" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 16" id="KW-0430">Lectin</keyword>
    <keyword evidence="15 16" id="KW-0464">Manganese</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B lectin" evidence="17">
        <location>
            <begin position="437"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU361242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="JAV77726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAB0799284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="568" mass="66014" checksum="D84F1FCE2BE22809" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1M3W8</accession>
    <name>A0A1Y1M3W8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vps72/YL1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_04708</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GEZM01041321">
        <property type="protein sequence ID" value="JAV80512.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01041320">
        <property type="protein sequence ID" value="JAV80518.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1M3W8"/>
    <dbReference type="FunCoup" id="A0A1Y1M3W8">
        <property type="interactions" value="13"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1M3W8"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029525">
        <property type="entry name" value="INO80C/Ies6"/>
    </dbReference>
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        <property type="entry name" value="Vps72/YL1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31200">
        <property type="entry name" value="INO80 COMPLEX SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31200:SF1">
        <property type="entry name" value="INO80 COMPLEX SUBUNIT C"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="YL1_C"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Vps72/YL1 C-terminal" evidence="5">
        <location>
            <begin position="67"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="JAV80512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0802522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="118" mass="13296" checksum="C17D4776C0577399" modified="2017-08-30" version="1">MTEFIKSEIRPVFKATTFQHTSKSNNKKRAWKSLKQIISTERSLQWPENYVHYSSINAPPSFKPAEKFSDLSGLPAPYTDPQTRLRFANKEEYGTLIGLPMDITAGYLALRGASSIVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1MBB4</accession>
    <name>A0A1Y1MBB4_PHOPY</name>
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        <recommendedName>
            <fullName evidence="3">Transmembrane protein 192</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_01487</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
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                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM192 family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:late endosome"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="TMEM192"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR31592:SF1">
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    </dbReference>
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        <property type="entry name" value="TMEM192"/>
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            <begin position="46"/>
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    </feature>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="JAV81605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0804517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="273" mass="31575" checksum="3CE4B2189C82B5D7" modified="2017-08-30" version="1">MVSLSRSANMNAGGATFFSESTNVEDREYLQPILESYGIFKPLNTIIPFSIHLLAIFTLEVMAIVFAAIHLNKDYQCREYFVLIYAHVGLWFLTLVVDQIARVKHYNLRMNGYLEFYKKIQMHHQLPIYIVSMWTTAILLIQTVMQHYYPDDFLERCVKGGLLSPISYICAVLSMEFLVIVVVSASYIRRVRKFNHQKPLPDVQKEEWNACSSSETFAQGEIGYRQLGDKVYDFIEKQADLIRHLKDHNARLGEKLMVVNAQLQGRSRAIPEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1MG46</accession>
    <name>A0A1Y1MG46_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_14957</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
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                <person name="Al-Wathiqui N."/>
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            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01032369">
        <property type="protein sequence ID" value="JAV84633.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000684">
        <property type="protein sequence ID" value="KAB0790870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1MG46"/>
    <dbReference type="FunCoup" id="A0A1Y1MG46">
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    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1MG46"/>
    <dbReference type="OrthoDB" id="5872154at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15729">
        <property type="entry name" value="FYVE_endofin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000084">
        <property type="entry name" value="Zinc finger, FYVE domain-containing 9b"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Domain of unknown function (DUF3480), N-terminal subdomain"/>
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    </dbReference>
    <dbReference type="Gene3D" id="4.10.720.10">
        <property type="entry name" value="Smad anchor for receptor activation, Smad-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
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        <property type="entry name" value="Ig-like_dom"/>
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        <property type="entry name" value="SARA-like_C"/>
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    <dbReference type="InterPro" id="IPR024608">
        <property type="entry name" value="SARA-like_SBD"/>
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    <dbReference type="InterPro" id="IPR037145">
        <property type="entry name" value="SARA_Smad-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46319">
        <property type="entry name" value="ZINC FINGER FYVE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46319:SF3">
        <property type="entry name" value="ZINC FINGER FYVE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
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    </dbReference>
    <dbReference type="Pfam" id="PF11409">
        <property type="entry name" value="SARA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11979">
        <property type="entry name" value="SARA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01422">
        <property type="entry name" value="SARA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="6">
        <location>
            <begin position="306"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="821"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="203"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="370"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="211"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="230"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="370"/>
            <end position="381"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="JAV84633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0790870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1013" mass="112591" checksum="3116201E1E82C8AD" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1MRU8</accession>
    <name>A0A1Y1MRU8_PHOPY</name>
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        <recommendedName>
            <fullName evidence="10">FACT complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PPYR_08978</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">1611_PpyrPB1</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">1611_PpyrPB1</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the FACT complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the peptidase M24 family. SPT16 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01023411">
        <property type="protein sequence ID" value="JAV88403.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01023410">
        <property type="protein sequence ID" value="JAV88404.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1MRU8"/>
    <dbReference type="FunCoup" id="A0A1Y1MRU8">
        <property type="interactions" value="2541"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1MRU8"/>
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    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035101">
        <property type="term" value="C:FACT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032786">
        <property type="term" value="P:positive regulation of DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01091">
        <property type="entry name" value="CDC68-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.150:FF:000003">
        <property type="entry name" value="FACT complex subunit SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.210:FF:000001">
        <property type="entry name" value="FACT complex subunit spt16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000017">
        <property type="entry name" value="FACT complex subunit SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FACT complex subunit spt16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.350.10:FF:000005">
        <property type="entry name" value="SPT16 homolog, facilitates chromatin-remodeling subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.210">
        <property type="entry name" value="FACT complex subunit Spt16p/Cdc68p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029148">
        <property type="entry name" value="FACT-SPT16_Nlobe"/>
    </dbReference>
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        <property type="entry name" value="Fact-SPT16_PH"/>
    </dbReference>
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        <property type="entry name" value="FACT_SPT16_C"/>
    </dbReference>
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        <property type="entry name" value="FACT_SPT16_M"/>
    </dbReference>
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        <property type="entry name" value="Pept_M24"/>
    </dbReference>
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        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="RTT106/SPT16-like_middle_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040258">
        <property type="entry name" value="Spt16"/>
    </dbReference>
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        <property type="entry name" value="Spt16_M24"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13980">
        <property type="entry name" value="CDC68 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13980:SF15">
        <property type="entry name" value="FACT COMPLEX SUBUNIT SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FACT-Spt16_Nlob"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24824">
        <property type="entry name" value="PH_SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08512">
        <property type="entry name" value="Rttp106-like_middle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08644">
        <property type="entry name" value="SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21091">
        <property type="entry name" value="SPT16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01285">
        <property type="entry name" value="FACT-Spt16_Nlob"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01287">
        <property type="entry name" value="Rtt106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01286">
        <property type="entry name" value="SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="FACT complex subunit SPT16 N-terminal lobe" evidence="12">
        <location>
            <begin position="6"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="FACT complex subunit SPT16 middle" evidence="13">
        <location>
            <begin position="531"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="domain" description="Histone chaperone RTT106/FACT complex subunit SPT16-like middle" evidence="14">
        <location>
            <begin position="808"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="434"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="919"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="443"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="464"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="929"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="987"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1016"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1032"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1062"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1079"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1089"/>
            <end position="1103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="JAV88403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAB0797985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1111" mass="126173" checksum="304E976DB8C0012A" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2023-09-13" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1N2Y9</accession>
    <name>A0A1Y1N2Y9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chitin-binding type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_13722</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01013990">
        <property type="protein sequence ID" value="JAV92234.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0794102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1N2Y9"/>
    <dbReference type="InParanoid" id="A0A1Y1N2Y9"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="JAV92234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0794102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="115" mass="12778" checksum="31D89C7A2926DA8D" modified="2017-08-30" version="1">MFPDPFDCQAYHFCTPDKLDAPVLQSTKAKCGDTSVGSYGYNPKTTFCSDKLSDAKCTDFPVPICERMLQKGIISRNPTLYYVCLNHPLLNDTSILYPFQMACPFGKTLSPCGCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1N416</accession>
    <name>A0A1Y1N416_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">acid phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PPYR_07339</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.2" evidence="3"/>
    <dbReference type="EMBL" id="GEZM01013380">
        <property type="protein sequence ID" value="JAV92604.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01013379">
        <property type="protein sequence ID" value="JAV92605.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1N416"/>
    <dbReference type="InParanoid" id="A0A1Y1N416"/>
    <dbReference type="OrthoDB" id="10257284at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF211">
        <property type="entry name" value="PROSTATIC ACID PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011907527" description="acid phosphatase" evidence="8">
        <location>
            <begin position="16"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="JAV92604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0799459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="367" mass="43108" checksum="6A86D0B68DBEB462" modified="2017-08-30" version="1">MRILLVLLNVVFVCTLPQNSTLKLVHVFFRHGSRIPDEHELYPNHERYESYKHIGFGQLTNAGKLRSYQLGKVLRNRYNDFLGEDFESNAAFIQSTNIERTKMTAMLLLAGLFPPSKRDKWNEKLNWIPIPLSLDQGDYDLWKPIYYCPTYLREMTRVLESQEAEELKQQYKHVFELATHKTGKAYNTMRDIFLLHQLIHVEQTMNATLPDWAVESFSDLRHIAIMQCYFENKNTLMKRLAGGRMLSKVMEHMKDKIQNTLNPPGRKIFLYSGHDYNIVNTLASLNLYNKLHFPNFNAAVCIELHQEPSTLAYFVKVFYLKDVFDEPEAQFIPECGYMCEFSKFQEILMPYLPINYTKECESVINLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1N6H9</accession>
    <name>A0A1Y1N6H9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PPYR_06072</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="GEZM01012225">
        <property type="protein sequence ID" value="JAV93078.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000004">
        <property type="protein sequence ID" value="KAB0800332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1N6H9"/>
    <dbReference type="FunCoup" id="A0A1Y1N6H9">
        <property type="interactions" value="95"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1N6H9"/>
    <dbReference type="OrthoDB" id="1022360at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.810.10">
        <property type="entry name" value="CRIB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
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    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR036936">
        <property type="entry name" value="CRIB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051931">
        <property type="entry name" value="PAK3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832:SF21">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00786">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00285">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="204"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
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        <source>
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        <source>
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        </source>
    </evidence>
    <sequence length="478" mass="54335" checksum="CFCF8A6A00819BD9" modified="2017-08-30" version="1">MNISKIFRRNTHKDDNGPSVIGHPTNVIHDIHVIKNKETGQLEGLPLAWQRQIGNLFTKAEQNKNPDALIHAIKYYNYSMKKKEEIEPFKHIVTERDIDEESEAIDLYMNSDAAHQSRECLLNDPVNVKLGQFGTRPETLPSLPPKKFGKLPTNLANGVEDLTLIPEESPIMRRKTQEFEFSDENILKELKKICSSEDPYERFNRSNKDLGAGASGIVFVATDLVTKQQVAIKDIDMTKQQRKELLLGEIKVLRDFKHKNLVNFLEAYLVYDDHLWVVMELLDGGPLTDVVTETIMKEGQIAAVCHEVLQAIQYLHTRGTIHRDIKSDNVLLGMDGSVKVTDFGFCANIVGDEQRQTMVGTPYWMAPEVVTRKQYGKKVDIWSLGIMAIEMIEGEPPYLKEPPLRALYLIAANGRPQIPGWKKLSLTLQSFIDDCLQVDVNKRASAEELLRHPFLQVRMELSTLTPLIKAAKKVLQKM</sequence>
</entry>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
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                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
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            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
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        </source>
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        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
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            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
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        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
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    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="project" value="TreeGrafter"/>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAB0795439.1"/>
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    </evidence>
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    </evidence>
    <sequence length="355" mass="40042" checksum="37A766487844B1B2" modified="2017-08-30" version="1">MEKPAANGVANLDEIKKMIKHDKMSIGRLKSLKLPRNLNLGGTKPKKVYTPNLNAIRNKEKQTQSTAKKPPAQRPQKRRLEDSKHTNNKVKYIQSDGVFSQGVGEAKHSTSQNIRVQYASNPTSLAIPKINKGQVIKNDDQRATELLYDNDTDSESDDDYFPVVLPLSCNKKPFSSKFSLKKEPLIKIKTEVPSDQNDTTQLLVNCKADVKVENPEPVVIRPQSAFMDDGTKYDDDNLVFSLIELPSTFIGKVWSDDAKETDLDYTLKCLPEGQIGKICVHKSGKMDFVVQNTEFRLRVAEPECFEQTAVQFPGKESISLEPSLVTLGNVTENLMVTPDWNKMFKSAQQKSKFYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
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    <name>A0A1Y1N8Q9_PHOPY</name>
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        <recommendedName>
            <fullName evidence="11">CCHC-type domain-containing protein</fullName>
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    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GEZM01010734">
        <property type="protein sequence ID" value="JAV93868.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0794033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1N8Q9"/>
    <dbReference type="FunCoup" id="A0A1Y1N8Q9">
        <property type="interactions" value="1617"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1N8Q9"/>
    <dbReference type="OrthoDB" id="431817at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008988">
        <property type="term" value="F:rRNA (adenine-N6-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041370">
        <property type="entry name" value="Mlase_EEF1AKMT1/ZCCHC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039846">
        <property type="entry name" value="ZCCHC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017921">
        <property type="entry name" value="Znf_CTCHY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13493:SF3">
        <property type="entry name" value="RRNA N6-ADENOSINE-METHYLTRANSFERASE ZCCHC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13493">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10237">
        <property type="entry name" value="N6-adenineMlase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51270">
        <property type="entry name" value="ZF_CTCHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CTCHY-type" evidence="7">
        <location>
            <begin position="341"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="6">
        <location>
            <begin position="413"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="JAV93868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0794033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="454" mass="52415" checksum="E993E03271AFD8BD" modified="2017-08-30" version="1">MSHVEVILEDLTSHPKCPHGPTVLFSRVSDGRRINFFACSACRDRKQCSFYLGTEEKMTSIAQQKWKEATENFTKCINHRKQFMGLNEIKLMSPSLRRYCHTCEQFVPSKYVDKHLAHLSTASISDYLLMHPSELLHPLDNPKKEAQFLFSHTAVKTLVEIIRQQSFSYVLSIGAPRIHEHISSSCEDMTSLLLDIDKRYHSFFGPLQFCWYNMFNNHFFSKDAKDIFHDFLKQSAGQLVIVMDPPFGGRIELLAQTVVSINRLNKAVNGSENDLPVLFVFPYFMEPQILNSFSDFVMLDYKVDYDNHPLFRDGPKGRKQGSPVRIFTNISVSSITLPADEGYKFCDKCVRWVSLENRHCNECELCTSKDGRTYVHCQKCQRCVKPTWSHCATCNRCAQTDHDCSEIVFSQACFHCKEPGHKKRECPKVNHAELQLKRKMGVKTKSRKKLKRAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1NAW9</accession>
    <name>A0A1Y1NAW9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PPYR_09824</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the DEAD box helicase family. DEAH subfamily. PRP16 sub-subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="GEZM01007689">
        <property type="protein sequence ID" value="JAV94993.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0795763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1NAW9"/>
    <dbReference type="FunCoup" id="A0A1Y1NAW9">
        <property type="interactions" value="1971"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1NAW9"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034458">
        <property type="term" value="F:3'-5' RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003006">
        <property type="term" value="P:developmental process involved in reproduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17983">
        <property type="entry name" value="DEXHc_DHX38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000001">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000007">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000313">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF91">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR ATP-DEPENDENT RNA HELICASE PRP16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="500"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="677"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="53"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="112"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1137"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
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        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
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                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <consortium name="Photinus pyralis genome working group"/>
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                <person name="Sander Lower S.E."/>
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</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
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            <taxon>Coleoptera</taxon>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
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                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2023-09-13" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1NDM5</accession>
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        <name type="scientific">Photinus pyralis</name>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
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                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
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        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
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                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
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                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </reference>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="18" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
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            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="19 20" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
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                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">1611_PpyrPB1</strain>
            <tissue evidence="19">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">1611_PpyrPB1</strain>
            <tissue evidence="19">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="FunCoup" id="A0A1Y1NDS7">
        <property type="interactions" value="60"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="STOLID, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10166">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="VGCC_alpha2"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="VWA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="3" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15" id="KW-0407">Ion channel</keyword>
    <keyword evidence="11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 16" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033289876" description="VWFA domain-containing protein" evidence="16">
        <location>
            <begin position="35"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="17">
        <location>
            <begin position="265"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="JAV96114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAB0801087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1204" mass="136205" checksum="3619F1C15D431A42" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1NH24</accession>
    <name>A0A1Y1NH24_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histidine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PPYR_07481</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">1611_PpyrPB1</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">1611_PpyrPB1</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(His) + L-histidine + ATP = L-histidyl-tRNA(His) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17313"/>
            <dbReference type="Rhea" id="RHEA-COMP:9665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9689"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78527"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.21"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.21" evidence="2"/>
    <dbReference type="EMBL" id="GEZM01002635">
        <property type="protein sequence ID" value="JAV97192.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1NH24"/>
    <dbReference type="FunCoup" id="A0A1Y1NH24">
        <property type="interactions" value="2393"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1NH24"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004821">
        <property type="term" value="F:histidine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006427">
        <property type="term" value="P:histidyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00773">
        <property type="entry name" value="HisRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00859">
        <property type="entry name" value="HisRS_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000008">
        <property type="entry name" value="histidine--tRNA ligase, cytoplasmic isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000021">
        <property type="entry name" value="Probable histidine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.10">
        <property type="entry name" value="S15/NS1, RNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00127">
        <property type="entry name" value="His_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015807">
        <property type="entry name" value="His-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004516">
        <property type="entry name" value="HisRS/HisZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033656">
        <property type="entry name" value="HisRS_anticodon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009068">
        <property type="entry name" value="uS15_NS1_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000738">
        <property type="entry name" value="WHEP-TRS_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00442">
        <property type="entry name" value="hisS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11476:SF7">
        <property type="entry name" value="HISTIDINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11476">
        <property type="entry name" value="HISTIDYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00458">
        <property type="entry name" value="WHEP-TRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001549">
        <property type="entry name" value="His-tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00991">
        <property type="entry name" value="WHEP-TRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47060">
        <property type="entry name" value="S15/NS1 RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51185">
        <property type="entry name" value="WHEP_TRS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WHEP-TRS" evidence="13">
        <location>
            <begin position="3"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="12">
        <location>
            <begin position="62"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="131"/>
            <end position="133"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="331"/>
            <end position="332"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001549-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="JAV97192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAB0799601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="511" mass="57194" checksum="5CDD51D1C2AD6A75" modified="2017-08-30" version="1">MSSKEKLEALIKDQGELVRKLKGAKESKQKIDNEVAKLLELKSQLSCENGEVQKFTLKTAKGTRDFSPQQMAIRETVFEKIISVFKRHGAETIDTPIFELKEVLTGKYGEDSKLIYDLKDQGGEILSLRYDLTVPFARYLAMNKITNIKRYHIAKVYRRDNPSITRGRYREFYQCDFDIAGAYDPMIPDAECVRVVQEILESLDIGSFVIKLNHRALLDGMFEACGVPPEKFRSICSAVDKLDKSPWADVRKEMIEEKGLTDEVADKIGQYVQMSGKHELVEKLLADANLTKVRAAVEGLEAMKLVLNYCDLLGVKDKAVFDLSLARGLDYYTGIIYEAVLLGEPVAEDMAGSVGSIAGGGRYDNLVGMFDAKHKQVPCVGVSIGIERIFAVIEAKLLAGTSKVRTTAVEVYVASAQKNLLEERMKVCKELWNEGIKAEQSYKKNPKLLAQLQHCEEYGIPLAIILGESEIQKGVVKLRNVVTRNEVEVPRGKLVDEIKKHLQPVYSNGST</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N3ZYH3</accession>
    <name>A0A5N3ZYH3_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_15570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01001915">
        <property type="protein sequence ID" value="KAB0790113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N3ZYH3"/>
    <dbReference type="InParanoid" id="A0A5N3ZYH3"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0790113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="106" mass="12851" checksum="7DDC0C2BB4126544" modified="2020-02-26" version="1" fragment="single">MWDIIIWKNENAIDFVPCNWANENNTMYKYPLGMSETKVRETIYECKELCENYKWCDVELRKQCIKSLQRAKELCDKGQYTSNLETSDDENEDTKRKRTKRYIEEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N3ZYI0</accession>
    <name>A0A5N3ZYI0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_15554</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01001882">
        <property type="protein sequence ID" value="KAB0790126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N3ZYI0"/>
    <dbReference type="InParanoid" id="A0A5N3ZYI0"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0790126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="301" mass="34443" checksum="1D43B5E4A1B99C11" modified="2020-02-26" version="1">MATEKILQWNARGIKNKYDEIRQMVGDIEPIIVAIQESKLQSGERFIMKNYQIFRNDLALEPGQRSHGGVLVMVRNDVHAKTIPLNTSLQAIACNRSIARFPGDNPYHQLGETLQNDINKVTEEAESRGFTFSGMKTRCLHFCRLRHKHEVPTLYLNETPIPNTQEIKFLGIILDSKLTWAKHINHLITKCKIIINRIRVIGSYTWGADRETLSKVINAFIGSRLQYGAEVYTNASKTYMNKIESVWNSALRIVTGAFRTSPIPSLNVESNSLPLRLRFEQQKFKHGVKRCAKPNHFLITL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N3ZZ64</accession>
    <name>A0A5N3ZZ64_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_15283</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01001432">
        <property type="protein sequence ID" value="KAB0790352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N3ZZ64"/>
    <dbReference type="InParanoid" id="A0A5N3ZZ64"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0790352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="302" mass="35527" checksum="AECEA47767306FC6" modified="2020-02-26" version="1" fragment="single">MRPILASGYPGYRRSLAQAKKKAAERELRMQSYTALRKQREEFRKRLVDLIVKKDDSMDIGPDEIPTAGEKEILRYYYYIRHGVDTVHVAPLDPKLLDTVLDLIPPKLKKWRELLKQNVNDVKEDYMLAMKKSIVDFLLRDPSFCESIVADFESSARMEVQHEGPTWGPNRRKAKTVLERCLFIVNPCSTQLLDLWYTQFRNFRLIDVDALRKREGPFNLADFQWIVAKQIEGFKGVLINSYYKQVYDIFSLGAKRNKLPKAAFPRRLKKFYNSCATYMTYNLQTLCLKSLYDYMDYITDIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N3ZZX3</accession>
    <name>A0A5N3ZZX3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Microtubule-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_14989</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
            <location evidence="1 6">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01001031">
        <property type="protein sequence ID" value="KAB0790606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N3ZZX3"/>
    <dbReference type="InParanoid" id="A0A5N3ZZX3"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031175">
        <property type="term" value="P:neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027324">
        <property type="entry name" value="MAP2/MAP4/Tau"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001084">
        <property type="entry name" value="MAP_tubulin-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11501">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11501:SF18">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00418">
        <property type="entry name" value="Tubulin-binding"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00229">
        <property type="entry name" value="TAU_MAP_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51491">
        <property type="entry name" value="TAU_MAP_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0790606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="193" mass="20923" checksum="77667DF09278DFA0" modified="2020-02-26" version="1" fragment="single">VPMNKIQVGSAPSPNLKVVKSKIGSLENATHKPGGGNIKIESKKIDFSTTSSRVTAKNDTYLPGGGDKKIQQQKLNWSAKSKVGSLENTTHKPKGGDKKIDIVKLDFKENAKSKVGSKDNIKHVPGGGDVKIETKKVDIKVQSKIGSLDNIKHKPGGGDKKIYDDKGYLRQMSAHSNASLDGSQNVDYLYTFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A0G3</accession>
    <name>A0A5N4A0G3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein MIX23</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Coiled-coil domain-containing protein 58</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_15182</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MIX23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000740">
        <property type="protein sequence ID" value="KAB0790814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A0G3"/>
    <dbReference type="FunCoup" id="A0A5N4A0G3">
        <property type="interactions" value="1025"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A0G3"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019171">
        <property type="entry name" value="MIX23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31905">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31905:SF2">
        <property type="entry name" value="PROTEIN MIX23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09774">
        <property type="entry name" value="MIX23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0790814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="125" mass="14544" checksum="9A511C957381BA09" modified="2020-02-26" version="1" fragment="single">ETLKNMRRVDDIIINTLNSVIPTDSFNPDAAKACKDLHNQLVEGNQHRKSAITKCINLSAEKLKHFREQRDTDPSTDQSLKSRNLLRAEQTKLRMLQVELSVEDLVEERSSKVFQERCRKYYKPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A0H9</accession>
    <name>A0A5N4A0H9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_15041</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000721">
        <property type="protein sequence ID" value="KAB0790837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A0H9"/>
    <dbReference type="InParanoid" id="A0A5N4A0H9"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF292">
        <property type="entry name" value="DDE TNP4 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="8">
        <location>
            <begin position="68"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0790837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="277" mass="31907" checksum="DADD415F459FEE7B" modified="2020-02-26" version="1" fragment="single">NNILTRSVASRFNVSKSTCWDVLQRTAHRLLEVNRLYGIIRWPYENEALETMRTFQRSISIPGIIGCIDGCHVKIIAPKDHPNSYVNRKKFHSVLLQGVCNEKKLFIDIYAGEPGSLHDYNLFLKSDLAELIRTQSVTFYNNGHLIGDLAYKLSTNMLIGFKNFGNINRREINFNKKLNSCRVEIENAFALLKGRFRRLKFIETVRLDFISLFIVTAAILHNVCLLSNDLPDDIVDLNEEIREVQRNDVNEMVANEGVDNNAEQKRRNILLNLPLDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2024-03-27" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A127</accession>
    <name>A0A5N4A127_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tyr recombinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_02832</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A127"/>
    <dbReference type="InParanoid" id="A0A5N4A127"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00397">
        <property type="entry name" value="DNA_BRE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="entry name" value="Intergrase catalytic core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35617:SF3">
        <property type="entry name" value="CORE-BINDING (CB) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35617">
        <property type="entry name" value="PHAGE_INTEGRASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="3">
        <location>
            <begin position="135"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0791032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="342" mass="38685" checksum="745B3509ABB4988A" modified="2020-02-26" version="1">MAPTSKTLKSRSSPSKITFPGFVQVIREAYRLRGIPPESFELFTNSISSATLKQYSSALSRWWYFCGTHGCDFYNSSHSDIIKFLTVEFNKGVSFSYLNVIRSAISFVRGNDLVNNLEVKRLFKGIFRSRPPRRKYDSIWDPNVILQHLQTLLPSEDLPLKDLSLKLVTLLALTTGHRIQTLSKIKLSNIVFLDKQIEIRIPDEIKTSGLNRVQPNLILPFFSDKKLCAAYTLKVYISRTRSLRNSADSLFISFNKPHCAIHSTQTLSRWIKIVLSDSGVDVSLFKSHSIRHASTSAAFRSGVNIDSIRKSAGWSKSSETFANFYNLPLCESNVFASSIINL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A165</accession>
    <name>A0A5N4A165_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Acid phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_02865</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A165"/>
    <dbReference type="FunCoup" id="A0A5N4A165">
        <property type="interactions" value="18"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A165"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF205">
        <property type="entry name" value="GH28721P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00616">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024359292" description="Acid phosphatase" evidence="3">
        <location>
            <begin position="19"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0791065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="385" mass="43630" checksum="59FDDE53ACC7275F" modified="2020-02-26" version="1">MLPMKWHVVVALMIGVVALIIYAGENAAISNGKTLKLVHIIFRHGIRTPADTYPNDPYINDDLYPVGWGQITNEGKQQLYEHGKYLRNRYGAFLGDHYTPSEYYVQTTDVDRTKVSAQCINAGLWPPNAAQKWGALDWQPIPSYSEPLNQDDLLLVRRPCPKYHKELQRVINTTEISNRLRASQTLFADLTKHTGKRVKDFEDVQDIFTTLMSEEAFGLKLPPWTAEFYPKRMLNATVFSYVLNAYNNNLNRLKGGVLVKKLIADWTAATSGGKRKASLFIGHDSTIVNLLSALQIWEPQLPGFAINVLFELSHNGTRDEYGVEIFLRNSTNVWDEPHRLTIPGCETFCPLPKLIELTKEVVPDDWDEECKIADAGYIPPTLRGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A1Z1</accession>
    <name>A0A5N4A1Z1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amine oxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_03150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A1Z1"/>
    <dbReference type="InParanoid" id="A0A5N4A1Z1"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046592">
        <property type="term" value="F:polyamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050281">
        <property type="entry name" value="Flavin_monoamine_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742:SF398">
        <property type="entry name" value="AMINE OXIDASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742">
        <property type="entry name" value="FLAVIN MONOAMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="1">
        <location>
            <begin position="19"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0791350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="382" mass="42701" checksum="24DE4F3B8C1D0BB3" modified="2020-02-26" version="1">MSIIGRNNPSVIIIGAGAAGIAAASRLYANGFEDITILEAGSRIGGRIHSVPFEGSYIDLGAQWCHGEKKNVVYELVNGLGILKEEDLSPKLYHSSSKVIEEAFQRRFLAVADDLDGAESLAQRIVERFQREVWEDEELVGECLEWLRKSALSYDGAFSWLNVSGCEDFEECEGEGHLSWNGLGYKTILKVLMSKFPDALESKLLLGKEVYQITWGDQVVVSCLDGTTYSADHVIVTPSLGVLKKCHKTLFHPELPLEKVIAIETLGFDAVGKIFLHFPNKWWDQNFTNINFVWSESDLKKSAEEFPCENFSVTQFQKGRSWVTGIFAIHTVLGSPNLLLAWASGEFVPEIETRTDQEIISGIEYILHKFLGKRHSPDAIIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A276</accession>
    <name>A0A5N4A276_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_03189</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A276"/>
    <dbReference type="InParanoid" id="A0A5N4A276"/>
    <dbReference type="OrthoDB" id="1434354at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902936">
        <property type="term" value="F:phosphatidylinositol bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174">
        <property type="entry name" value="ALPHA-TOCOPHEROL TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174:SF213">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="125"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0791389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="273" mass="31434" checksum="5097C6950702DA5D" modified="2020-02-26" version="1">MAVVNLGFKFDDLISDNRTTVERVSSIKGWQRSTPYPKLTDEQIGLFLIACRNDREFAKRTIVMYFETKLGAPEIFRDRNVASEDLRRIANVVNVAVMPKRLGGAAVMVASLKDTNYRNFDFRTYVQLYTMTLESLLYGDPPTNVITVMDSKGVTLLHMTKMRLKLVKHFANFNQSGNPPKLGKIYVLNVNYVTYAVVNFIKPFLQLDVLENMEMHKANANLDRFYDCIPRAYLPKELGGELEPIGFYSEENLRRLASLRPYFEALQQQVYET</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A2K2</accession>
    <name>A0A5N4A2K2_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_03308</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A2K2"/>
    <dbReference type="FunCoup" id="A0A5N4A2K2">
        <property type="interactions" value="158"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A2K2"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070531">
        <property type="term" value="C:BRCA1-A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031436">
        <property type="term" value="C:BRCA1-BARD1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0085020">
        <property type="term" value="P:protein K6-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF8">
        <property type="entry name" value="BRCA1-ASSOCIATED RING DOMAIN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="32"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="65"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0791508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="117" mass="12837" checksum="4ACD21445B0BEDCC" modified="2020-02-26" version="1">MSELVWGIKNGDLEQVKDIIEKKAVNVNEEIDGRPPILYAADYGQADVIEYLITLGADVNSKDKHGITAILAAIWEGHKDCVKLLLERGARRDGVAPDGTTYVDSAENTEIKQMLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A2S7</accession>
    <name>A0A5N4A2S7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PXA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_03379</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A2S7"/>
    <dbReference type="InParanoid" id="A0A5N4A2S7"/>
    <dbReference type="OrthoDB" id="5582218at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003114">
        <property type="entry name" value="Phox_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775:SF3">
        <property type="entry name" value="SORTING NEXIN-13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02194">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="PXA" evidence="3">
        <location>
            <begin position="111"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="588"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="684"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="684"/>
            <end position="695"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0791579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="969" mass="108528" checksum="CBC96D8626853B98" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A314</accession>
    <name>A0A5N4A314_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PPYR_03492</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A314"/>
    <dbReference type="InParanoid" id="A0A5N4A314"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002737">
        <property type="entry name" value="AGAP008430-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001370">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000512">
        <property type="entry name" value="zinc finger protein 197 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050758">
        <property type="entry name" value="Znf_C2H2-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23234:SF9">
        <property type="entry name" value="ZINC FINGER PROTEIN 850-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23234">
        <property type="entry name" value="ZNF44 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="10"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="38"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="66"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="94"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="122"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="150"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="178"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAB0791692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="202" mass="23207" checksum="84936B01B3C3DE9A" modified="2020-02-26" version="1">MRWHTGEKPFACDLCGKKFARSEHVRIHRRIHTGERPHACKICHKSFVQYASLAAHSRTHSGERPHTCRVCGKSFSQSASLTYHTRTHTGETPFTCQICNKGFAYSGNLSIHMRFHRNERPFSCDVCGRTFVTSSHLAAHTKQHTGDRPHRCDVCGKAFMRSEHLKDHRVTHTGEKPHACKLCPKRYTQSSHLNRHMKSHKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A384</accession>
    <name>A0A5N4A384_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_03585</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A384"/>
    <dbReference type="FunCoup" id="A0A5N4A384">
        <property type="interactions" value="28"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A384"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF186">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="3">
        <location>
            <begin position="314"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0791785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="676" mass="76192" checksum="4C0452C866081D3B" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A3X1</accession>
    <name>A0A5N4A3X1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PPYR_13981</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A3X1"/>
    <dbReference type="InParanoid" id="A0A5N4A3X1"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000142">
        <property type="entry name" value="homeobox protein OTX2 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45793">
        <property type="entry name" value="HOMEOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45793:SF5">
        <property type="entry name" value="HOMEOTIC PROTEIN OCELLILESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="9">
        <location>
            <begin position="58"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="60"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="117"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="31"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="117"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="145"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="186"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="206"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0792020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="316" mass="34985" checksum="45C6B9269C19C6A1" modified="2020-02-26" version="1">MNLSGYLKSPTGPPHGHFPSHPGLGTGLGSGMPMPGLGPFGLPHSLDPVGFPQGVNPRKQRRERTTFTRAQLDVLESLFAKTRYPDIFMREEVALKINLPESRVQVWFKNRRAKCRQQLQQQQQNKSSSSRSPVTPSKAKPSKVSPISTPTAGNASTTNIPPPSTSVSPPIVHIKKEPPQIPHPYRSNNGNLTPLGSNTSSVITTPSPPITPSSNPPLSYQHDSYNSFNWHTNGHNSSPHHYYGQNYNAAYYSQMEYFNQQSSQNQMQMGNHVSGGYHQMSGYGNGMTMGMTGTHHQNFNPRHPDCNNLDYMNQIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A550</accession>
    <name>A0A5N4A550_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_14348</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A550"/>
    <dbReference type="InParanoid" id="A0A5N4A550"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007623">
        <property type="term" value="P:circadian rhythm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.15.10.30:FF:000001">
        <property type="entry name" value="Takeout-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.30">
        <property type="entry name" value="Haemolymph juvenile hormone binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010562">
        <property type="entry name" value="Haemolymph_juvenile_hormone-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038606">
        <property type="entry name" value="To_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008:SF18">
        <property type="entry name" value="BCDNA.GH05536-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008">
        <property type="entry name" value="PROTEIN TAKEOUT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06585">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00700">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0090">Biological rhythms</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00060902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0792389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="226" mass="25580" checksum="DEFA360A2ABE0029" modified="2020-02-26" version="1" fragment="single">SSFTICKLNDPKLNECYSRATERALKILREPIPELSLPSIEPLKIDRVDVPADSNSINFRQTLLNIEVYNLTNSMVNRSQLTFGDDTYHMKSILYNPLVTIKGIAELDGKILVLQIKDKGPFEITLERSTGVFEMSGRIVDKGGKRYLTVERTACKLKPDNAIIKFENLFEGNRELGEIVNAALNEHWREILDELGSAYEEALAAMLKGYGQRIVNKVPFENLFAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A6Z4</accession>
    <name>A0A5N4A6Z4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CUE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_12705</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A6Z4"/>
    <dbReference type="FunCoup" id="A0A5N4A6Z4">
        <property type="interactions" value="296"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A6Z4"/>
    <dbReference type="OrthoDB" id="5577209at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14364">
        <property type="entry name" value="CUE_ASCC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052586">
        <property type="entry name" value="ASCC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041800">
        <property type="entry name" value="ASCC2_CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21494:SF0">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21494">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 2 ASC-1 COMPLEX SUBUNIT P100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CUE" evidence="2">
        <location>
            <begin position="502"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="615"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="623"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="634"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="644"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="667"/>
            <end position="686"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0793085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="717" mass="82959" checksum="82BED111532A9C6C" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A8Y3</accession>
    <name>A0A5N4A8Y3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Hexosyltransferase</fullName>
            <ecNumber evidence="11">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PPYR_13369</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Golgi apparatus membrane</location>
            <topology evidence="1 11">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="11"/>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A8Y3"/>
    <dbReference type="FunCoup" id="A0A5N4A8Y3">
        <property type="interactions" value="80"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A8Y3"/>
    <dbReference type="OrthoDB" id="115198at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.50:FF:000001">
        <property type="entry name" value="Hexosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214:SF376">
        <property type="entry name" value="HEXOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01762">
        <property type="entry name" value="Galactosyl_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAB0793749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="361" mass="42516" checksum="9767F900AB53D614" modified="2020-02-26" version="1">MLERRFWSNCALILLLLTSISIWHIYTSHSITIRSAYDYNTSTRYSPLSFTLHTANSSYKHPMYQLPQLDYNTLMNLTTFDFAILNKCKTWPLLLILVHSAPNNYHRRKSIRETWGSKLQNASIFFMLGLARESRLQKKIAEENRNHRDIVQGTFLDVYRNVTYKHVMSLKFAIYHCPNAKYILKTDDDVFVNMPRIVNFLTVDLSPYGAERLLSCSKRAHSPVKRSFRSKWRVSFNEYQNEYYPAYCPGWVIMYSPDVIFVLYREVQKFDYFWIDDVLITGILRERENIEIHDATSMILPCDNLKKILQHEIIDQGADFLYGPADLSIREMYALFHLVKNVSSLKSRPSARRFLKLSSPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AA60</accession>
    <name>A0A5N4AA60_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dynein regulatory complex protein 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PPYR_13817</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Flagellum axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DRC10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0794197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AA60"/>
    <dbReference type="InParanoid" id="A0A5N4AA60"/>
    <dbReference type="OrthoDB" id="536093at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042815">
        <property type="entry name" value="DRC10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31598:SF1">
        <property type="entry name" value="DYNEIN REGULATORY COMPLEX PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31598">
        <property type="entry name" value="IQ DOMAIN-CONTAINING PROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0969">Cilium</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0282">Flagellum</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="308"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0794197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="384" mass="44834" checksum="2DEB3E9D9A203C20" modified="2020-02-26" version="1">MSTEGEFTIFQVPSDQAELQLQYDRVIRVLDLVIEKVKICVCLPDFLAQSSKLLDVDVGYIQEICAKYCYRQPSISTGKCTASSVRRKTKPSALDSLRRFVNPQMTQVVEILYKNYQLKKASLENDLLISGESARFVSSLKLMRDIMDERCKVNAVEQIMREKFLKSAYKENIEMKGHLLALTSEGEKQRREFNLQINSKNATLLGLQKEISRRNTALKEETKLIAEKNEAGLAEDRETSKLRQQELATESKTVANQYDNLLSQHLKSERKLRVKRLKTETQLSGWLSKYDFDMQDRQAEFDVQMSGFEEEQDAFDALVVKMNELEEMSASFMEEKEEEDEQQRLAVNFFSRNRAARVIQRYYRAYRFRLLKSKKKDKQKKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AAJ4</accession>
    <name>A0A5N4AAJ4_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_11176</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0794337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AAJ4"/>
    <dbReference type="FunCoup" id="A0A5N4AAJ4">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AAJ4"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16021">
        <property type="entry name" value="ALP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000017">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004245">
        <property type="entry name" value="DUF229"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10974:SF9">
        <property type="entry name" value="DUF229 DOMAIN CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10974">
        <property type="entry name" value="FI08016P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02995">
        <property type="entry name" value="DUF229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0794337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="724" mass="83377" checksum="A9CFC2B1F608ECD0" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AB20</accession>
    <name>A0A5N4AB20_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CHK kinase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_11352</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0794513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AB20"/>
    <dbReference type="InParanoid" id="A0A5N4AB20"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004119">
        <property type="entry name" value="EcKL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012">
        <property type="entry name" value="PROTEIN KINASE-LIKE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012:SF30">
        <property type="entry name" value="PROTEIN KINASE-LIKE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02958">
        <property type="entry name" value="EcKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0794513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="271" mass="31463" checksum="46A12A0D52C43D0E" modified="2020-02-26" version="1">MSKNNHAIVLTENQQIAFNGFLKRAGVGNFSISLSSGVEAGENLCGVIIKADVVWTSENEKSTSHYILKCVPSSEILQNLLPVQPSFLIEIYVYSKIFQEFNIIQREYNIKAPFDCFPVYYASLSTTHDKMIVLQNVKALSYRHYDRSQPMDYPHLLLVVKEYARLHALSYVIRHYKPVLFEEFERNTVHHFLQDWSYEGIMIVVQHRMDHALKALESIIDTALYEKFLHFTQNVRSVCTKLLNSKTKHRVVSHIDCGISNFLFKYDVSKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ABG5</accession>
    <name>A0A5N4ABG5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Fringe-like glycosyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PPYR_11468</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Endomembrane system</location>
            <topology evidence="9">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0794629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ABG5"/>
    <dbReference type="InParanoid" id="A0A5N4ABG5"/>
    <dbReference type="OrthoDB" id="8959630at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003378">
        <property type="entry name" value="Fringe-like_glycosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10811">
        <property type="entry name" value="FRINGE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02434">
        <property type="entry name" value="Fringe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="Fringe-like glycosyltransferase" evidence="11">
        <location>
            <begin position="51"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAB0794629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="344" mass="39640" checksum="A8ABA6588BBE983E" modified="2020-02-26" version="1">MSKRTVLKALFTVIIIGNCMLLLLLYTPTRCTHLQVTKYTKKNIPYHTTKPTTLDDVYIAVRTSKSNHNGRMAVIHQTWFQLAKKQTWFFTDVEDEKLQNLTDGHMINTKCGESHSRRDLCCKMGVEISTFMTASESKWFCHFDDDNYINIPKLVDVLNGYDPDADWYLGKLSLDHPAIVTHNETKKTTRFWFGTGGAGVCISRPLVTKMKPFTIGDQFMRTCDLVAIGDDATMGYILHAQNISLTVIDRFHSHYEQFKCIPRETIEKEIVLSYKGENILEIEGFDLETDPTRFMSLHCVLFPNADLCTTMKRTYTIPTKNTQHSCIIHKFLSIISVSFWCRYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ABK0</accession>
    <name>A0A5N4ABK0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nuclear cap-binding protein subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_11531</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NCBP3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0794692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ABK0"/>
    <dbReference type="InParanoid" id="A0A5N4ABK0"/>
    <dbReference type="OrthoDB" id="422106at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019416">
        <property type="entry name" value="NCBP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16291">
        <property type="entry name" value="NUCLEAR CAP-BINDING PROTEIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16291:SF0">
        <property type="entry name" value="NUCLEAR CAP-BINDING PROTEIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10309">
        <property type="entry name" value="NCBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="19"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="369"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="415"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="434"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="470"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="558"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="577"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="601"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="638"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0794692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="656" mass="75031" checksum="9506BBF1D4964B99" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ABM2</accession>
    <name>A0A5N4ABM2_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">tRNA (uracil-O(2)-)-methyltransferase</fullName>
            <ecNumber evidence="10">2.1.1.211</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PPYR_11553</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Adenosyl-L-methionine (AdoMet)-dependent tRNA (uracil-O(2)-)-methyltransferase.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Probable adenosyl-L-methionine (AdoMet)-dependent tRNA (uracil-O(2)-)-methyltransferase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>uridine(44) in tRNA(Ser) + S-adenosyl-L-methionine = 2'-O-methyluridine(44) in tRNA(Ser) + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43100"/>
            <dbReference type="Rhea" id="RHEA-COMP:10339"/>
            <dbReference type="Rhea" id="RHEA-COMP:10340"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74478"/>
            <dbReference type="EC" id="2.1.1.211"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the TRM44 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.211" evidence="10"/>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0794714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ABM2"/>
    <dbReference type="FunCoup" id="A0A5N4ABM2">
        <property type="interactions" value="1446"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4ABM2"/>
    <dbReference type="OrthoDB" id="10047021at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141101">
        <property type="term" value="F:tRNA(Ser) (uridine(44)-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011671">
        <property type="entry name" value="tRNA_uracil_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21210">
        <property type="entry name" value="TRNA (URACIL-O(2)-)-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21210:SF0">
        <property type="entry name" value="TRNA (URACIL-O(2)-)-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07757">
        <property type="entry name" value="AdoMet_MTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 10" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0794714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="590" mass="67409" checksum="E544AD73F8D6B0D3" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ADP1</accession>
    <name>A0A5N4ADP1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_12275</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0795436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ADP1"/>
    <dbReference type="InParanoid" id="A0A5N4ADP1"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000013">
        <property type="entry name" value="CUGBP Elav-like family member 1 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052462">
        <property type="entry name" value="SLIRP/GR-RBP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48027">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN 87F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="82"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0795436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="172" mass="18906" checksum="2AD04B9DFE19A861" modified="2020-02-26" version="1">MLHSLDALAGKLSPGSKAGPTSPPASQLDGNANRVHPYHKHGTISNSPMNNNNISSKHNKNNILNASPSSNPEQDQPDPDNIKMFVGQVPHSMDENDLKQLFEEYGRVHSINVLRDKNTGISRGCCFVTFYTRKAALLAQDALHNVKTLRGMHHPIQMKPADSENRNGKCGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AF49</accession>
    <name>A0A5N4AF49_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_10013</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0795952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AF49"/>
    <dbReference type="InParanoid" id="A0A5N4AF49"/>
    <dbReference type="OrthoDB" id="8300214at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861:SF1">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="35"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0795952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="274" mass="31613" checksum="81B65E991A7B6A48" modified="2020-02-26" version="1">MFEMGRGEVYIQYGSLPEKTAVQILSNFKEAALWKEGCKVLDIGCGPGNVTHDILYPILPKSTSEIVGVDKCPEFIEYARNNYEEKPIFSFRVLDIVNDEVPEELEQKFDYAVSFLCFHQFSDHKAAFENVSKMLKPGGEILFYFAAKASTFQLYETLANNEKLSGYFPDWEKYCSPYKDSLNIKKDIENFVNKMGYKILSLRIDKKHHSFPMKYFQQLQQSLVPLPLPDDFFSEIRNDMLIAIRNLKLSKIDGNSEEYFEFIGNIAILHAVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AFZ9</accession>
    <name>A0A5N4AFZ9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PPYR_10295</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AFZ9"/>
    <dbReference type="InParanoid" id="A0A5N4AFZ9"/>
    <dbReference type="OrthoDB" id="434041at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="10">
        <location>
            <begin position="24"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="55"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="260"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="445"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="488"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="6">
        <location>
            <begin position="24"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0796234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="820" mass="92312" checksum="F35B6DBABEDB9B2A" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AG19</accession>
    <name>A0A5N4AG19_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Nuclear receptor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PPYR_10353</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nuclear hormone receptor family. NR0 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AG19"/>
    <dbReference type="FunCoup" id="A0A5N4AG19">
        <property type="interactions" value="18"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AG19"/>
    <dbReference type="OrthoDB" id="5850793at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000034">
        <property type="entry name" value="CLUMA_CG002674, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050200">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48092">
        <property type="entry name" value="KNIRPS-RELATED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="13">
        <location>
            <begin position="2"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="95"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="253"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="286"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="297"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="309"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAB0796292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="339" mass="37475" checksum="F15617423D6010C2" modified="2020-02-26" version="1">MNQTCKVCGEPAAGFHFGAFTCEGCKSFFGRSYNNLSSISECKNNGECVINKKNRTACKACRLRKCLLVGMSKSGSRYGRRSNWFKIHCLLQEQQQQQQQQHHHHQQSPSGGLPGMKPPIKSPHGHQNISMGILGSQPFPPPLLHLPRTKEELMLLGFDDYKHAASPSVSSPESHNSDSSVELSDARRTLPLFPGLLPPTFLPPPGLLFPPGYPPFYAGLLQPANNNNRLMRNHNPGVEAFNKRVFLDAVLQSQRSPTPEEREPVRPTASPIQEDPIDLSMKPSSDRGSSPSPSDRSGSERTERGAGSEADEESDCDSETEMRRIKILRPTPLDLTTKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AG39</accession>
    <name>A0A5N4AG39_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Replication protein A subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PPYR_10348</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">1611_PpyrPB1</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 11">As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10 11">Component of the heterotrimeric canonical replication protein A complex (RPA).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the replication factor A protein 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AG39"/>
    <dbReference type="FunCoup" id="A0A5N4AG39">
        <property type="interactions" value="2330"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AG39"/>
    <dbReference type="OrthoDB" id="1751331at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04474">
        <property type="entry name" value="RPA1_DBD_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04475">
        <property type="entry name" value="RPA1_DBD_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04476">
        <property type="entry name" value="RPA1_DBD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000041">
        <property type="entry name" value="Replication protein A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000064">
        <property type="entry name" value="Replication protein A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000090">
        <property type="entry name" value="Replication protein A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047192">
        <property type="entry name" value="Euk_RPA1_DBD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013955">
        <property type="entry name" value="Rep_factor-A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007199">
        <property type="entry name" value="Rep_factor-A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031657">
        <property type="entry name" value="REPA_OB_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004591">
        <property type="entry name" value="Rfa1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00617">
        <property type="entry name" value="rpa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47165">
        <property type="entry name" value="OS03G0429900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47165:SF4">
        <property type="entry name" value="OS03G0429900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04057">
        <property type="entry name" value="Rep-A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08646">
        <property type="entry name" value="Rep_fac-A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16900">
        <property type="entry name" value="REPA_OB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Replication factor-A protein 1 N-terminal" evidence="14">
        <location>
            <begin position="22"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="OB" evidence="13">
        <location>
            <begin position="218"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Replication protein A OB" evidence="16">
        <location>
            <begin position="314"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="Replication factor A C-terminal" evidence="15">
        <location>
            <begin position="469"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="167"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00058595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00062035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF16900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAB0796287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="622" mass="69674" checksum="30B45C3308E0FCF9" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AGX7</accession>
    <name>A0A5N4AGX7_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PPYR_10663</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AGX7"/>
    <dbReference type="FunCoup" id="A0A5N4AGX7">
        <property type="interactions" value="2197"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AGX7"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044285">
        <property type="entry name" value="PWP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14091">
        <property type="entry name" value="PERIODIC TRYPTOPHAN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14091:SF0">
        <property type="entry name" value="PERIODIC TRYPTOPHAN PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="271"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="314"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="400"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0796602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="498" mass="55088" checksum="D702D1AA888B7C32" modified="2020-02-26" version="1">MNKIKKNASFGTFEEVPFTIHFAVIQGWTARSGDASFGFKINSNTKVIERLLSVLKFVADTNGQDSKEVSSRPTPGPPLGLGEMQSKDLNSDLKLKKFMFAFSVDFWKFMRIAAFLVSFNHSGFFGIFGASRSSSASSVSLITGSMSLVEIDGDAEDHFSESDDSDKEDDEIKPDDNLILAGRVEEDASTLEIYVYNPTEESLYVHHDFSLSAYPLCLEWLDYEPGHSAGNYCAIGSMNSIIDIWDLDIINCIEPAYKLGRKPSRKKGLSRIGHSDAVLSLAWNSNFHHVLASGSVDRSILLWDLDSGEPATTINAFTDKVQCLEWKPDESQTLLAGGCDNTVKLFDCSNPENYKTWQTSGEVESLAWNPIESSSFCVGTNTGVIHCFDYRQESPIWTIPDAHEKEVTGLNISDRYAGFLVTASADGLVKVWDYTASNQPRMISDKDFGMNLVHCLALCPDWPFVIAAGGDNKMNNFSVYDLQNSDAGRGVVWTCNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AGZ2</accession>
    <name>A0A5N4AGZ2_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-actin monooxygenase</fullName>
            <ecNumber evidence="4">1.14.13.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PPYR_10652</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">1611_PpyrPB1</strain>
            <tissue evidence="20">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-methionyl-[F-actin] + NADPH + O2 + H(+) = L-methionyl-(R)-S-oxide-[F-actin] + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:51308"/>
            <dbReference type="Rhea" id="RHEA-COMP:12953"/>
            <dbReference type="Rhea" id="RHEA-COMP:12956"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:45764"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.13.225"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Mical family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.225" evidence="4"/>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AGZ2"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120501">
        <property type="term" value="F:F-actin monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09439">
        <property type="entry name" value="LIM_Mical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000004">
        <property type="entry name" value="protein-methionine sulfoxide oxidase MICAL2 isoform X1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050540">
        <property type="entry name" value="F-actin_Monoox_Mical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057494">
        <property type="entry name" value="Rossman_Mical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23167:SF54">
        <property type="entry name" value="[F-ACTIN]-MONOOXYGENASE MICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23167">
        <property type="entry name" value="CALPONIN HOMOLOGY DOMAIN-CONTAINING PROTEIN DDB_G0272472-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25413">
        <property type="entry name" value="Rossman_Mical"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13 16" id="KW-0440">LIM domain</keyword>
    <keyword evidence="7 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="10" id="KW-0521">NADP</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 16" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="18">
        <location>
            <begin position="544"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="18">
        <location>
            <begin position="1539"/>
            <end position="1645"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="19">
        <location>
            <begin position="1891"/>
            <end position="1956"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="970"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1689"/>
            <end position="1733"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="2041"/>
            <end position="2180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="2564"/>
            <end position="2624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="2641"/>
            <end position="2803"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="2815"/>
            <end position="2894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="1714"/>
            <end position="1726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="2057"/>
            <end position="2068"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="2070"/>
            <end position="2094"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="2112"/>
            <end position="2126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="2127"/>
            <end position="2140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="2146"/>
            <end position="2158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="2159"/>
            <end position="2173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="2579"/>
            <end position="2589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="2599"/>
            <end position="2608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="2610"/>
            <end position="2622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="2659"/>
            <end position="2674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="2701"/>
            <end position="2716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="2724"/>
            <end position="2736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="2769"/>
            <end position="2778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="2779"/>
            <end position="2789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="2790"/>
            <end position="2800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="2815"/>
            <end position="2827"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAB0796591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="2954" mass="334134" checksum="7B57D52C392AA23D" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AHV8</accession>
    <name>A0A5N4AHV8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Xenotropic and polytropic retrovirus receptor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_10940</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SYG1 (TC 2.A.94) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AHV8"/>
    <dbReference type="FunCoup" id="A0A5N4AHV8">
        <property type="interactions" value="2014"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AHV8"/>
    <dbReference type="OrthoDB" id="9970435at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000822">
        <property type="term" value="F:inositol hexakisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016036">
        <property type="term" value="P:cellular response to phosphate starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14477">
        <property type="entry name" value="SPX_XPR1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004342">
        <property type="entry name" value="EXS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10783:SF127">
        <property type="entry name" value="LD30826P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10783">
        <property type="entry name" value="XENOTROPIC AND POLYTROPIC RETROVIRUS RECEPTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03124">
        <property type="entry name" value="EXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03105">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51380">
        <property type="entry name" value="EXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="263"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="328"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="359"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="458"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="536"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="domain" description="SPX" evidence="8">
        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="EXS" evidence="7">
        <location>
            <begin position="417"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0796879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="671" mass="78119" checksum="398F741C86DE2F12" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AI76</accession>
    <name>A0A5N4AI76_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Bromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_11121</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0797060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A5N4AI76">
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    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AI76"/>
    <dbReference type="OrthoDB" id="303107at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090537">
        <property type="term" value="C:CERF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05509">
        <property type="entry name" value="Bromo_gcn5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029614">
        <property type="entry name" value="CECR2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47092">
        <property type="entry name" value="CAT EYE SYNDROME CRITICAL REGION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47092:SF1">
        <property type="entry name" value="CHROMATIN REMODELING REGULATOR CECR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="4">
        <location>
            <begin position="422"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
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            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
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            <end position="801"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
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            <end position="1023"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1047"/>
            <end position="1255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1282"/>
            <end position="1339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1354"/>
            <end position="1398"/>
        </location>
    </feature>
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        <location>
            <begin position="1592"/>
            <end position="1638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="274"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="334"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="561"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="596"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
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    </feature>
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    <feature type="compositionally biased region" description="Basic residues" evidence="3">
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        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
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            <end position="1079"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1084"/>
            <end position="1120"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
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            <end position="1171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1180"/>
            <end position="1199"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1208"/>
            <end position="1241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1282"/>
            <end position="1314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1326"/>
            <end position="1336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1592"/>
            <end position="1603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1622"/>
            <end position="1638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0797060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1805" mass="203625" checksum="5230C79717C6A044" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AIX7</accession>
    <name>A0A5N4AIX7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_08296</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AIX7"/>
    <dbReference type="FunCoup" id="A0A5N4AIX7">
        <property type="interactions" value="24"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AIX7"/>
    <dbReference type="OrthoDB" id="385235at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035770">
        <property type="term" value="C:ribonucleoprotein granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000963">
        <property type="term" value="P:mitochondrial RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044528">
        <property type="term" value="P:regulation of mitochondrial mRNA stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013579">
        <property type="entry name" value="FAST_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050870">
        <property type="entry name" value="FAST_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010622">
        <property type="entry name" value="FAST_Leu-rich"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013584">
        <property type="entry name" value="RAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21228">
        <property type="entry name" value="FAST LEU-RICH DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21228:SF72">
        <property type="entry name" value="LD32258P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06743">
        <property type="entry name" value="FAST_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08368">
        <property type="entry name" value="FAST_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08373">
        <property type="entry name" value="RAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00952">
        <property type="entry name" value="RAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51286">
        <property type="entry name" value="RAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RAP" evidence="3">
        <location>
            <begin position="834"/>
            <end position="892"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0797302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="897" mass="104012" checksum="EDB457DC11C4AE24" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AKF4</accession>
    <name>A0A5N4AKF4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Proteasomal ATPase OB C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PPYR_08777</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AKF4"/>
    <dbReference type="InParanoid" id="A0A5N4AKF4"/>
    <dbReference type="OrthoDB" id="10255768at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000067">
        <property type="entry name" value="26S protease regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002861">
        <property type="entry name" value="Cell division control protein 48 homolog E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasomal ATPase second OB" evidence="5">
        <location>
            <begin position="107"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase AAA-type core" evidence="4">
        <location>
            <begin position="220"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0797784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="264" mass="29319" checksum="822ABBFB273DCF2C" modified="2020-02-26" version="1">MGQNHSGPGSGEKKEEKDKKKKYEPPIPTRVGKKKRKTKGPDTALKLPAVTPHTRCRLKLLKLERIKDYLLMEEEFIRNQEHLKPQEEKNEEERSKVDDLRGTPMSVGTLEEIIDDNHAIVSTSVGSEHYVSILSFVDKDQLEPGCSVLLNHKVHAVVGVLGDDTDPMVTVMKLEKAPQETYADIGGLDSQIQEIKESVELPLTHPEYYEEMGIKPPKGVILYGAPGTGKTLLAKAVANQTSATFLRVVGSELIQKYLVSITVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AKQ4</accession>
    <name>A0A5N4AKQ4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_08892</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AKQ4"/>
    <dbReference type="InParanoid" id="A0A5N4AKQ4"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="265"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="125"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="343"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="400"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="443"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="38"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="416"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="452"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="492"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0797899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="566" mass="64812" checksum="52D09769E20B53EA" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ALP1</accession>
    <name>A0A5N4ALP1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">TraB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_09219</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ALP1"/>
    <dbReference type="FunCoup" id="A0A5N4ALP1">
        <property type="interactions" value="420"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4ALP1"/>
    <dbReference type="OrthoDB" id="48306at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14726">
        <property type="entry name" value="TraB_PrgY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002816">
        <property type="entry name" value="TraB/PrgY/GumN_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046345">
        <property type="entry name" value="TraB_PrgY-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21530">
        <property type="entry name" value="PHEROMONE SHUTDOWN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21530:SF7">
        <property type="entry name" value="TRAB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01963">
        <property type="entry name" value="TraB_PrgY_gumN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="332"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0798226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="374" mass="42325" checksum="C9B094C2591651E0" modified="2020-02-26" version="1">MDNSISNFELSESTVRLGSDSEKSSEKSDNFEELVEPDTDESSNGTNENKVKLHSEDFDNNLPETVTLLKHPETGVKVYLVGTAHFSKESQDDVIKVIRNVQPQIIVLELCDARTSILSLDEATILEEAKNIDFDKVRSTIRTNGFYNGVMYLLLLNMSAHITKEIGMAPGGEFRVAYKEARTLPSCSIHLGDRPIQITLKRALSRLSWFQTIKLGWHLLTNKEPISKEEIEKCKRRDMLEQLLADMAGEYPALGEVFVDERDIYLTHSLQMVSGPRLHKPVVDQEPPTVVGVVGMGHVVGITRLWLKDQRPFLANILTIPPPSLSSKIFRITFRLSLLTLGGFVVYRFVPMPKMFRETCRTGFERIVSNIKKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AN75</accession>
    <name>A0A5N4AN75_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">VWFC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_06657</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0798777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AN75"/>
    <dbReference type="InParanoid" id="A0A5N4AN75"/>
    <dbReference type="OrthoDB" id="365605at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024321298" description="VWFC domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0798777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="277" mass="31325" checksum="D9B628DADB47C32C" modified="2020-02-26" version="1">MNVVSTFVFSCLILMINAHIYDDRGTLIYEDLSCKPIKQRPSDPLPASYDCDEAFSKPCYYKGKNYNLNKPVEWQQSLTACSSSCRCKENGFLCADLRCPEIGLVTLTSPDCFHIYSINECCNVGQVCPPFENLPTCVVDGKTYMKGQKFFPNNTVLHCVCDENFNGKYEAPHCRKINCGIKLKYAEEIGKRCAPFYDDRAEKKCPSSWICPSDDMKDSVISVSNKLGNELACSYGDRKIPFQDFFERKSTNFLHPPKTMIRCTCSVPPLLTCAIMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AN77</accession>
    <name>A0A5N4AN77_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">KIF-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PPYR_06685</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the KIF-binding protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0798805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AN77"/>
    <dbReference type="FunCoup" id="A0A5N4AN77">
        <property type="interactions" value="1845"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AN77"/>
    <dbReference type="OrthoDB" id="409897at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021952">
        <property type="term" value="P:central nervous system projection neuron axonogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990535">
        <property type="term" value="P:neuron projection maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022083">
        <property type="entry name" value="KBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46321:SF1">
        <property type="entry name" value="KIF-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46321">
        <property type="entry name" value="KIF1-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12309">
        <property type="entry name" value="KBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0798805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="597" mass="69556" checksum="6A040C6193102FAD" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ANK0</accession>
    <name>A0A5N4ANK0_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">PPYR_06802</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">1611_PpyrPB1</strain>
            <tissue evidence="21">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="17">Postsynaptic cell membrane</location>
            <topology evidence="17">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0798922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ANK0"/>
    <dbReference type="FunCoup" id="A0A5N4ANK0">
        <property type="interactions" value="109"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4ANK0"/>
    <dbReference type="OrthoDB" id="203862at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034707">
        <property type="term" value="C:chloride channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004890">
        <property type="term" value="F:GABA-A receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099095">
        <property type="term" value="F:ligand-gated monoatomic anion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19007">
        <property type="entry name" value="LGIC_ECD_GABAR_GRD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19049">
        <property type="entry name" value="LGIC_TM_anion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000065">
        <property type="entry name" value="GABA-gated ion channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000003">
        <property type="entry name" value="Putative gamma-aminobutyric acid receptor subunit gamma-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001390">
        <property type="entry name" value="GABAAa_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00860">
        <property type="entry name" value="LIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01079">
        <property type="entry name" value="GABAARALPHA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0868">Chloride</keyword>
    <keyword evidence="11" id="KW-0869">Chloride channel</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="16 18" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 18" id="KW-0406">Ion transport</keyword>
    <keyword evidence="15" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 18" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0770">Synapse</keyword>
    <keyword evidence="3 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 18" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024473730" evidence="18">
        <location>
            <begin position="23"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="284"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="316"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="515"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="19">
        <location>
            <begin position="80"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="20">
        <location>
            <begin position="290"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAB0798922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="551" mass="64220" checksum="E621FE99A2126E37" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ANP4</accession>
    <name>A0A5N4ANP4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sulfatase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PPYR_06806</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sulfatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0798926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A5N4ANP4"/>
    <dbReference type="FunCoup" id="A0A5N4ANP4">
        <property type="interactions" value="82"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4ANP4"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16029">
        <property type="entry name" value="4-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047115">
        <property type="entry name" value="ARSB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10342">
        <property type="entry name" value="ARYLSULFATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10342:SF264">
        <property type="entry name" value="MIP05773P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00149">
        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024378555" description="Sulfatase N-terminal domain-containing protein" evidence="9">
        <location>
            <begin position="19"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="580"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase N-terminal" evidence="10">
        <location>
            <begin position="23"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="611"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="618"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0798926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="640" mass="72316" checksum="38A70F0C4AF155C3" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ANV0</accession>
    <name>A0A5N4ANV0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein THEM6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_06843</name>
        <name evidence="5" type="ORF">PPYR_06849</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the THEM6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0798963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0798969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ANV0"/>
    <dbReference type="FunCoup" id="A0A5N4ANV0">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4ANV0"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00586">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051490">
        <property type="entry name" value="THEM6_lcsJ_thioesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12475">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12475:SF4">
        <property type="entry name" value="PROTEIN THEM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13279">
        <property type="entry name" value="4HBT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00041112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0798963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0798969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="211" mass="24843" checksum="C3B4505DB458CF8A" modified="2020-02-26" version="1">MLKVELDLDLMMLLCAIVLAAIVLLFVLIDIQYFVRSIFVLVWGRIFEPRKRPDELTTIFGMCTTSDLDIIFAHMNNARYVRELDFARFHFYDRTGIYKAILGKKGNVLQSACIIRYRRTIPLFTMYRITTKMVYWDDKSIYLEQRFISLRDKFIKAVVFSKQGVVGVNAAEIVNKLLNKDDDYRPEKSEELEHFIKCLDASSMRLRKKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AQ45</accession>
    <name>A0A5N4AQ45_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_07329</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AQ45"/>
    <dbReference type="InParanoid" id="A0A5N4AQ45"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0799449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="149" mass="17275" checksum="978599143DFEE647" modified="2020-02-26" version="1">MDEELFDFILMDQNLLLNKPTRKWVHEFNEDHSQSEYYSTCLPMRGHPDKFKKYPRMTVETFDYILSHIEGDIRKWSNFRTQDLYRASRKTGIGTGRKTNYFDSCQTSSDPSRLPGTTTYSSVGGDTAPSSLFSSDSARPIQTRPDRQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AQM5</accession>
    <name>A0A5N4AQM5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PPYR_07507</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AQM5"/>
    <dbReference type="InParanoid" id="A0A5N4AQM5"/>
    <dbReference type="OrthoDB" id="67700at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070382">
        <property type="term" value="C:exocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017156">
        <property type="term" value="P:calcium-ion regulated exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08403">
        <property type="entry name" value="C2B_Synaptotagmin-3-5-6-9-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000005">
        <property type="entry name" value="Synaptotagmin 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000011">
        <property type="entry name" value="Synaptotagmin 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001565">
        <property type="entry name" value="Synaptotagmin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024:SF374">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024">
        <property type="entry name" value="SYNAPTOTAGMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00360">
        <property type="entry name" value="C2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00399">
        <property type="entry name" value="SYNAPTOTAGMN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024321515" description="C2 domain-containing protein" evidence="8">
        <location>
            <begin position="16"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="9">
        <location>
            <begin position="144"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="9">
        <location>
            <begin position="276"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0799627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="437" mass="49845" checksum="B641C8CBF5573841" modified="2020-02-26" version="1">MALVLLAAVSYQCTATWKWIREKTCRDLSEGEDCLAKQTSICISHSLPDLQTEPLKKEYVQEHKDSIKKVLRQTTLPIVPTRHQTFQRQLSHRLEMPSTIQFSICSLEHKSESSIVGLIKPELYKKDLVRQSSNDSSGGPEMEYCGKLHFALRYDKDVEGLVVKVLESRDLPIKDVTGSSDPYVKLYLLPDRKKKYQTKVHRKNLNPVFNETFIFSVPYEELKQRYLQFSVYDFDRFSRHDLIGHVVLKGLLETADLQQEIEYTMNILCPPQDKVDLGEIMLSLCYLPTAGRLTLTVIKGRNLKAMDITGKSDPYVKVYLLCQGKRIKKKKTTVKKSTLCPVYNEALVFDVPAENIEDVSMIVKVIDYDRIGSNELMGCTAIGSSFIGIGKDHWLEMLDNPRRPVAQWYPLIESVPGYIPPSSTDTLPLSLSCLNSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AR27</accession>
    <name>A0A5N4AR27_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_07660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AR27"/>
    <dbReference type="InParanoid" id="A0A5N4AR27"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058913">
        <property type="entry name" value="Integrase_dom_put"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46791:SF13">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46791">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24764">
        <property type="entry name" value="rva_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase core" evidence="1">
        <location>
            <begin position="104"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0799780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="360" mass="42026" checksum="41433E0097AD7108" modified="2020-02-26" version="1">MSETQLITFYFTLGLSNDEILAFLKVQHNCNISLRTLKRRLKNLKLFRKKGYSPINQVATYLRTQVSKSGQLYGYRWMHLKCIQEGFVVRQETIRRLLKSIDPVDSYDKLKPFGIGINGCIDGFSRHIMWMKAGRTNNNPRVIGGYFVDTIQKIGGIPLTIRADMGTENRHIEQMQVFFRRDTGINIHRPAFLYGKSTANQKIECWWGILRKHNAEFWMNLFKKIQDDGYFNGSYLEKALIQFCFLRIIQSELNSVVLEWNSHNRSSSKNSILPRGKPLIMYHIPEIYRSNDYLISVEFDDLEIAREECVFLDQECPCDKDVFELCNILLNEAAVENIPSDPYNAIDVYLYLRNKLSCLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-06-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AR61</accession>
    <name>A0A5N4AR61_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_07666</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AR61"/>
    <dbReference type="InParanoid" id="A0A5N4AR61"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0799786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="97" mass="11641" checksum="2DDBB4E86477850A" modified="2020-02-26" version="1">MLQLVETQPLKYPTYRQEGSRLYKQDVQKRLETAHAKAKRRYDLRKRPQQFEEGTSVWKKKLCPVGCVEEFHSEIRSKVRRAVYDKEKDLTIDLRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ARG1</accession>
    <name>A0A5N4ARG1_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_07794</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ARG1"/>
    <dbReference type="InParanoid" id="A0A5N4ARG1"/>
    <dbReference type="OrthoDB" id="7457915at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.30">
        <property type="entry name" value="Haemolymph juvenile hormone binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010562">
        <property type="entry name" value="Haemolymph_juvenile_hormone-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038606">
        <property type="entry name" value="To_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008:SF32">
        <property type="entry name" value="CIRCADIAN CLOCK-CONTROLLED PROTEIN DAYWAKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008">
        <property type="entry name" value="PROTEIN TAKEOUT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06585">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00700">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024446067" evidence="1">
        <location>
            <begin position="21"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0799914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="245" mass="27898" checksum="E38E03CFDDAEAB50" modified="2020-02-26" version="1">MSTILSYTCLFAAIFQLSSAAVPFQVCKRTDPKLAECLKPAIENALILLENGLPEYGIPSIQPISVESWMVPARPPLVYDQKFRNSKFYNYPLTKIEDLSINIDDPNIFIGFTAHNHNVSYETEFEFDGAIIDGEDLSCSGDLTYIYNEMEFQLNFTGTEVTIGGDKKINITNVDMNVISMERFFTEFRGKDTERVAKLSKFYHNNAQYLVAKEKDVYEKAYANIFKDVANDVLSKFSFDSLFPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ARW9</accession>
    <name>A0A5N4ARW9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-fold modifier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_07929</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UFM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0800049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ARW9"/>
    <dbReference type="FunCoup" id="A0A5N4ARW9">
        <property type="interactions" value="963"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4ARW9"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990592">
        <property type="term" value="P:protein K69-linked ufmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000044">
        <property type="entry name" value="Ubiquitin-fold modifier 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005375">
        <property type="entry name" value="UFM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15825">
        <property type="entry name" value="UBIQUITIN-FOLD MODIFIER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15825:SF0">
        <property type="entry name" value="UBIQUITIN-FOLD MODIFIER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03671">
        <property type="entry name" value="Ufm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0800049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="72" mass="7780" checksum="DA29DEF90FBADB1A" modified="2020-02-26" version="1">MIFVSRLSVPEATPFTAVLKFAAEEFRVPPATSAIITDDGVGINPQQTAGNVFLKHGSELRIIPRDRVGSQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AS61</accession>
    <name>A0A5N4AS61_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GYF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_08009</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0800129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A5N4AS61">
        <property type="interactions" value="864"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AS61"/>
    <dbReference type="OrthoDB" id="48509at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00072">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051640">
        <property type="entry name" value="GRB10-interact_GYF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003169">
        <property type="entry name" value="GYF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035445">
        <property type="entry name" value="GYF-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14445:SF36">
        <property type="entry name" value="FI03272P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14445">
        <property type="entry name" value="GRB10 INTERACTING GYF PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02213">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00444">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55277">
        <property type="entry name" value="GYF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50829">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GYF" evidence="2">
        <location>
            <begin position="438"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="738"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="825"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1126"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1249"/>
            <end position="1286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="738"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="855"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="987"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1014"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1134"/>
            <end position="1152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0800129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1318" mass="148035" checksum="BE1787C3161FC626" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AS62</accession>
    <name>A0A5N4AS62_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_08054</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0800174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AS62"/>
    <dbReference type="FunCoup" id="A0A5N4AS62">
        <property type="interactions" value="244"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AS62"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43115">
        <property type="entry name" value="DEHYDROGENASE/REDUCTASE SDR FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43115:SF4">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE SDR FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0800174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="205" mass="22757" checksum="509B5C59E15E2B8E" modified="2020-02-26" version="1" fragment="single">IVSPGAVASELRREFSESELNERPMMKCEDVAKTVIYILSTPPNVQIQDIVIHGDLNIWKRTLYTNCLALSIFTREAIRVMKAHDIDGLIINNSSIAARYVPNHPLPNSSPNVYPATKFAVNALSNTLTNELRHEKSKIRVSCVSPGLTLTEIFRYEPPEVLAAVGDSIPFLTSENIADSVMFILSTPPDVQVQEIIVRPVGEFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AT60</accession>
    <name>A0A5N4AT60_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ZP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_06274</name>
        <name evidence="6" type="ORF">PPYR_06275</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000004">
        <property type="protein sequence ID" value="KAB0800534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000004">
        <property type="protein sequence ID" value="KAB0800535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AT60"/>
    <dbReference type="FunCoup" id="A0A5N4AT60">
        <property type="interactions" value="5"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AT60"/>
    <dbReference type="OrthoDB" id="10062424at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056953">
        <property type="entry name" value="CUT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055355">
        <property type="entry name" value="ZP-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46560">
        <property type="entry name" value="CYPHER, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46560:SF2">
        <property type="entry name" value="DUSKY-LIKE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25057">
        <property type="entry name" value="CUT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00100">
        <property type="entry name" value="Zona_pellucida"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00241">
        <property type="entry name" value="ZP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51034">
        <property type="entry name" value="ZP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033494418" description="ZP domain-containing protein" evidence="3">
        <location>
            <begin position="24"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="566"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="domain" description="ZP" evidence="4">
        <location>
            <begin position="83"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="412"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0800534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0800535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="617" mass="66744" checksum="31C76B7E2E9A9336" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ATV7</accession>
    <name>A0A5N4ATV7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PPYR_06513</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000004">
        <property type="protein sequence ID" value="KAB0800774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ATV7"/>
    <dbReference type="InParanoid" id="A0A5N4ATV7"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050382">
        <property type="entry name" value="MFS_Na/Anion_cotransporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662:SF336">
        <property type="entry name" value="LP19554P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0800774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="249" mass="27835" checksum="4E6957F78375BA6A" modified="2020-02-26" version="1">MFRDRRRRTPWSKILHCSKIRALFVLLCCNGWNLNYFRYYGPLYFKRITSSTNSGAFWLTSAAFLTRMVLGILCLPLLRYIIIQNRMSVTVLRKSIAFIAQVIPGTIALTTIAVHCKESVNIVIGLLILGFNGAFIGSGFINALDLAPHFAQALFAPMQALICVITAVMPFMVAYISELVKEKVYVNVMMIGLVYVVGGLTFITFGSATVQPWDIAEARRMVQSSISVTHLGYELDREADDDEQNSGLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AUC0</accession>
    <name>A0A5N4AUC0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ceramide glucosyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.80</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PPYR_05295</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">1611_PpyrPB1</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>N-(9Z-octadecenoyl)-sphing-4-enine + UDP-alpha-D-xylose = beta-D-xylosyl-(1&lt;-&gt;1')-N-(9Z-octadecenoyl)-sphing-4-enine + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:70247"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57632"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:77996"/>
            <dbReference type="ChEBI" id="CHEBI:189081"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:70248"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>UDP-alpha-D-xylose + an N-acylsphing-4-enine = a beta-D-xylosyl-(1&lt;-&gt;1')-N-acylsphing-4-enine + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:70243"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:52639"/>
            <dbReference type="ChEBI" id="CHEBI:57632"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:189068"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:70244"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.80" evidence="5"/>
    <dbReference type="EMBL" id="VVIM01000003">
        <property type="protein sequence ID" value="KAB0800941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AUC0"/>
    <dbReference type="FunCoup" id="A0A5N4AUC0">
        <property type="interactions" value="610"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AUC0"/>
    <dbReference type="OrthoDB" id="1483400at2759"/>
    <dbReference type="UniPathway" id="UPA00222"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008120">
        <property type="term" value="F:ceramide glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006679">
        <property type="term" value="P:glucosylceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02520">
        <property type="entry name" value="Glucosylceramide_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000041">
        <property type="entry name" value="UDP-glucose ceramide glucosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025993">
        <property type="entry name" value="Ceramide_glucosylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12726">
        <property type="entry name" value="CERAMIDE GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12726:SF0">
        <property type="entry name" value="CERAMIDE GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13506">
        <property type="entry name" value="Glyco_transf_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="281"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="316"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAB0800941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="397" mass="45616" checksum="E3419A4D9DD01CA8" modified="2020-02-26" version="1">MAPMIYTLYGFAIFFFVFWCALWIVHLIAIFYGKYRLHSKFTSQPSDTCYFGVSILKPLMGVDPNLFTNLETFFNMNYPKYELLFCVEDDTDPAIMLVKSLMEKYPKVDAKLFIGAAIVGVNPKINNMHYAYEATAYDFILISDSGIRMKEDTLQDMMNHMTDKIALVHQMPFSADRSGFAAALEKIYFGTAHSRVYLTADCIKVNCHTGMSALMRKSVLEEEGGLKTFGCYLAEDFFIAKSFMDKGWKITICSQPAIQNSGICDIHSFQSRLTRWAKLRVAMIPLVTIFEPLTECMVIGGFTAWAVGVLFQWDSFAFYLVHVLIWFICDWVLLTIVQNGSLPFNKFDFVVGWLFRECSGPYLFLHALFNPTIRWRTRVYKLAWGGIAQEIKPRIKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AUG7</accession>
    <name>A0A5N4AUG7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Microtubule-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PPYR_05257</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
            <location evidence="1 6">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000003">
        <property type="protein sequence ID" value="KAB0800903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AUG7"/>
    <dbReference type="InParanoid" id="A0A5N4AUG7"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031175">
        <property type="term" value="P:neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027324">
        <property type="entry name" value="MAP2/MAP4/Tau"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001084">
        <property type="entry name" value="MAP_tubulin-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11501">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11501:SF18">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00418">
        <property type="entry name" value="Tubulin-binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00229">
        <property type="entry name" value="TAU_MAP_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51491">
        <property type="entry name" value="TAU_MAP_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="208"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="37"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="144"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="208"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="234"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0800903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="248" mass="26536" checksum="4F70B6630544C0B1" modified="2020-02-26" version="1">MADVKHFSDNVTNISNRSNGTSSHSNNAEGDNDSGVDESTQGNDHLNSEYSTGKKSSKSSTPRSATTPTKNKSFTRVAKSPNPKSPETPTSTADKKKVPMNKIQVGSAPSPNLKVVKSKIGSLENATHKPGGGNIKIESKKIDFSTTSSRVTAKNDTYLPGGGDKKIQQQKLNWSAKSKVGSLENTTHKPKGGDKKIDIVKLDFKENAKSKVGSKDNIKHVPGGGDVKNSSQADVREPVSDENLNRQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AUP9</accession>
    <name>A0A5N4AUP9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cupin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_05294</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000003">
        <property type="protein sequence ID" value="KAB0800940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AUP9"/>
    <dbReference type="FunCoup" id="A0A5N4AUP9">
        <property type="interactions" value="7"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AUP9"/>
    <dbReference type="OrthoDB" id="10063099at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050910">
        <property type="entry name" value="JMJD6_ArgDemeth/LysHydrox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12480">
        <property type="entry name" value="ARGININE DEMETHYLASE AND LYSYL-HYDROXYLASE JMJD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12480:SF19">
        <property type="entry name" value="CUPIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="Cupin-like" evidence="2">
        <location>
            <begin position="105"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0800940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="307" mass="35351" checksum="95CFCE716FB21ADF" modified="2020-02-26" version="1">MQKAEKRFNSILQKTTNSKISCDELLTLDVVHRLCGPKKGNTKVKCFIFVIVVACMWWAYFGISSTSECLVEMPFESSKIFREPENCGICLNTFEVPKVENISKQNFEQLYVNTGKPVVVTDGTKNWLAMQTFSFNFFKQLYQSVDQHISTQSECQFFPYKTEFTSLAEALNMSVERSRLEPETLPWYIGWSNCNDKAGNILREYYNRPYFLPDNSESIALSWIFMGGPGFGAHMHVDNVLYPSWQAQIRGKKLWRLAPPPECFYRCREMEVTVSPGDIIVVDTNRWYHQTHILPGGVSITIGSEFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-09-13" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AUR4</accession>
    <name>A0A5N4AUR4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4806 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_05332</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000003">
        <property type="protein sequence ID" value="KAB0800978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AUR4"/>
    <dbReference type="InParanoid" id="A0A5N4AUR4"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0800978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="53" mass="5908" checksum="8026A528C1C306A8" modified="2020-02-26" version="1" fragment="single">VIYFAKMGGTNLYDFVKRCLAPVISDKTAMTYSFIGRKGKKNFSSLKLSQAVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AV67</accession>
    <name>A0A5N4AV67_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein unc-50 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_05571</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the unc-50 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000003">
        <property type="protein sequence ID" value="KAB0801217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AV67"/>
    <dbReference type="FunCoup" id="A0A5N4AV67">
        <property type="interactions" value="2175"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AV67"/>
    <dbReference type="OrthoDB" id="10027013at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007881">
        <property type="entry name" value="UNC-50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12841">
        <property type="entry name" value="PROTEIN UNC-50 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12841:SF6">
        <property type="entry name" value="PROTEIN UNC-50 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05216">
        <property type="entry name" value="UNC-50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0801217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="252" mass="30300" checksum="1C6E5D10B814F3B9" modified="2020-02-26" version="1">MYSRSTSPLPLPVNHQRDCMSAATKRWKYLRRMFKFNQMDFEFAFWQMLYLLIAPQKVYRNFQYRKQTKSQFARDDPAFLVLFAAWLCITSIGFAIVLRLTFWKFVHFLLYVIFIDCIGIGLIIATFFWYILNRYFRTSNDQDIEWGYAFDVHLNAFFPPLVILHFFQLFFYNGLISHDWFISRYLGNTFWLTAVSYYIYITFLGYSSLPMLKRTHLLLVPLPIVILFYVVSLAAGFNITYFLMTFYTERIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B044</accession>
    <name>A0A5N4B044_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tyr recombinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_05167</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B044"/>
    <dbReference type="InParanoid" id="A0A5N4B044"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="entry name" value="Intergrase catalytic core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0802981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="120" mass="13863" checksum="550A68A84B95E6D6" modified="2020-02-26" version="1">MKVVLIMGYCGVCRREELTNMSVNDVEYKADSILISVPKTKNNVSRLFAVTDTKWINIIKTYTNLRPSHINSNRFFLNYRNGSCTVQPIGINKIGKMPDDLVIVVKLFIQHTRYHGPFWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B106</accession>
    <name>A0A5N4B106_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BESS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_00060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B106"/>
    <dbReference type="InParanoid" id="A0A5N4B106"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0803090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="116" mass="12933" checksum="C3A9203E3A31B4CC" modified="2020-02-26" version="1">MAAIMEQNAALRKRKFEEKTSSQKKHTCFESLDETDMFFLGLARMAKQLPKTEQASIKLTLSNTILQAELRCAQAQSAHTPTSRSCTTVQPLFPPHENSRPSTSSSYCVQPLVSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B1Q0</accession>
    <name>A0A5N4B1Q0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PLAC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PPYR_00418</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B1Q0"/>
    <dbReference type="FunCoup" id="A0A5N4B1Q0">
        <property type="interactions" value="35"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4B1Q0"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.830">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050439">
        <property type="entry name" value="ADAMTS_ADAMTS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010294">
        <property type="entry name" value="ADAMTS_spacer1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010909">
        <property type="entry name" value="PLAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723">
        <property type="entry name" value="ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723:SF316">
        <property type="entry name" value="LONELY HEART, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05986">
        <property type="entry name" value="ADAMTS_spacer1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08686">
        <property type="entry name" value="PLAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19030">
        <property type="entry name" value="TSP1_ADAMTS"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50900">
        <property type="entry name" value="PLAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024433477" description="PLAC domain-containing protein" evidence="6">
        <location>
            <begin position="22"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="domain" description="PLAC" evidence="7">
        <location>
            <begin position="762"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="363"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0803448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="804" mass="89357" checksum="6A978F5D3A6A5CFE" modified="2020-02-26" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B1W7</accession>
    <name>A0A5N4B1W7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Flavin-containing monooxygenase</fullName>
            <ecNumber evidence="8">1.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_00569</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the FMO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="8"/>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B1W7"/>
    <dbReference type="InParanoid" id="A0A5N4B1W7"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000138">
        <property type="entry name" value="Flavin-containing monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000960">
        <property type="entry name" value="Flavin_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000332">
        <property type="entry name" value="FMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00370">
        <property type="entry name" value="FMOXYGENASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0274">FAD</keyword>
    <keyword evidence="3 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0803599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="413" mass="47290" checksum="64651DF3B8104AD7" modified="2020-02-26" version="1">MKIVIIGAGIAGVVTLKYALNAGHECDVFEQTGELGGTWVYSDQTDMDEFGFPSHRTMYKGLITNVPKEMMEFLNFRHSSDINESYITQPLVLKYLRDFADKFDLEKHIQYYKRVTKVAPVGTQWSLTVLDLKTKVETSLRYDAVFVCNGHFFHPHIPNIEGQDIFKGSQLHSRDYRTPEKFKNKRVLIIGGSYSGSDIASHILSSARSVRLVYISHPKPLLINVENAILKPGVKELNEGGAVFIDGSKEDFDIIMYCTGYKHFYPFLTKECGITVEDSCVQYLYKHVINIERPTLFFIGIPTLVGAYINSDLQARFAVAFLDGKFNLPPKDVMLKEIQDHFKDLEHKNLPLRYFHNIGLELRAYMSDLCQISGIEPFPEVKIRIHEHVINTLVTCKRNTKYVIIDEEQFVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B4D7</accession>
    <name>A0A5N4B4D7_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_01384</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B4D7"/>
    <dbReference type="InParanoid" id="A0A5N4B4D7"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF2">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase zinc-binding" evidence="2">
        <location>
            <begin position="274"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0804414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="404" mass="46881" checksum="AAA23A7A2D79ED80" modified="2020-02-26" version="1">MMFRQILVHPHDRKYQQILWRYERQQPIMTYTLNTLTFGTKCAPYLSTRCLLQLAIDNEESYPKTAQIIKNSFYIDDLLVSVDTIEEALQLYKELTVIFSTAGFQLRKWSSNNQRILYDILGNGNNDEKLVQFCEGKELKTLDIKLTLLNVRDDQFNLFTRYSTLSKLQRVVAYCFKFKNITLGKNKTLTNILSVSELEISLTALIKIAQHEQFSQEIRLLQKSQPLNNNSKLIFLHPFLDEHGVIRVGGRLKNSLLNYENQFPIILCGKHIFTKLIIKHEHLKHLHAGTQNVLSIIRLKYWPIHGKNAVKSVIRSCVRCFRANPKPTSFLMGNLPTARVIPSRTFSNSGKAFDTLFKLFHVLNLNYPQESEHIYLIIQKAVYKIDTPYDKNIPSIMDVVRLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B5Z4</accession>
    <name>A0A5N4B5Z4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PPYR_02007</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">1611_PpyrPB1</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0805037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B5Z4"/>
    <dbReference type="FunCoup" id="A0A5N4B5Z4">
        <property type="interactions" value="317"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4B5Z4"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11056">
        <property type="entry name" value="CYP6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000042">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050476">
        <property type="entry name" value="Insect_CytP450_Detox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292:SF100">
        <property type="entry name" value="CYTOCHROME P450 6A16, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0492">Microsome</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="436"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAB0805037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="491" mass="56174" checksum="48AD1C73086290D1" modified="2020-02-26" version="1">MLLLLVFIVSIVVVYVYFKWNFTYWKRRKVPFINPSIPFGTAENPFARKEYIGHRIQKYYTNFKAKGWNHVGLYFFSSPSYLPIHPDYIRNIMSKHFRYFTDRGTYANEKGDPLSAHLFNLEGEKWGKLRKKLTPTFTSGKIKLMFPTLVRCSETLVKAIGKSNPIEAKELLGCFTTDVIGSCAFGVECDSFANPDSEFRRYGKSVFTTVIKGQTLASAIAMVNPGLAQWLNIKLIPNHITQFFMKLVHDTVSYRETNALNRRDFMQILIDLKNSKSDDDRLSIEEMAANTFVFFLAGFETSSTTMAFCLYELAKNPAIQDTLRQEISAIVEKHQAVTYEAVTEMKYLSQVLDETLRKYPPAPLIPRVCVEDYQIPGSDATIGKGTRIYIPVFALHHDPEYFPNPEEFVPARFSDENSIQRHPYVYLPFGEGPRICIGARFGLMQAKVGLIALLRKFAFRLHEKTGSSLQFDPTNLIPTAKDGIWLNAREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B5Z8</accession>
    <name>A0A5N4B5Z8_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_01750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B5Z8"/>
    <dbReference type="FunCoup" id="A0A5N4B5Z8">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4B5Z8"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23992">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.20">
        <property type="entry name" value="Pheromone/general odorant binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006170">
        <property type="entry name" value="PBP/GOBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036728">
        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01395">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024406854" evidence="1">
        <location>
            <begin position="16"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0804780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="131" mass="15235" checksum="643AC16B3C41F632" modified="2020-02-26" version="1">MKRFTFLIILCVVVAKRRIPEVQVKQWERIISSFKADCIEEANVDPILVERMVYELEFPEDEGLKKYWRCTHNHFHSIKANHNLDGEQISNQVPFVPPQLALQCTTESNHIKDLIEKAFEGAKCIINKLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B6F4</accession>
    <name>A0A5N4B6F4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_02116</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0805146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B6F4"/>
    <dbReference type="InParanoid" id="A0A5N4B6F4"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0805146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="92" mass="10638" checksum="085B92FFB982C39C" modified="2020-02-26" version="1" fragment="single">LIEENVILFFGVPTSIIVDNGVQFRSKEFQKLMSTYNVSIRYTPYYHAQANPTERVKKVLKTVLSSFVEDNQKNWSSLLQKVAFAIRSAKHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-06-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B787</accession>
    <name>A0A5N4B787_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_02437</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0805467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B787"/>
    <dbReference type="InParanoid" id="A0A5N4B787"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0805467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="101" mass="11907" checksum="D455F50EE420BB9A" modified="2020-02-26" version="1">MRITKIRVKETQGLNLPGPNFCESEQVVLTEFSALNLIGCHFIAVWNTSTKCIRSMGVTYRVYFQVGGILSNEPPKYYFILRFYGKFYYTFHMYVPKFIHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1JUD3</accession>
    <name>A0A1Y1JUD3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PPYR_12073</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GEZM01102882">
        <property type="protein sequence ID" value="JAV51751.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0795234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1JUD3"/>
    <dbReference type="InParanoid" id="A0A1Y1JUD3"/>
    <dbReference type="OrthoDB" id="1916003at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd01804">
        <property type="entry name" value="Ubl_midnolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039336">
        <property type="entry name" value="Midnolin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23010">
        <property type="entry name" value="MIDNOLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23010:SF1">
        <property type="entry name" value="MIDNOLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="4">
        <location>
            <begin position="22"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="181"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="245"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="152"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="188"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="253"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="303"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="JAV51751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0795234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="313" mass="34710" checksum="80439ABCF5FE21E7" modified="2017-08-30" version="1">MEDSAESNFNPISQGCGPHSQISIQISPTTGGDFHLTVDPDITVENVKKLISKRLKVPRDRICLLFRDKQLQEGNLLQHGVTDGSKVTLLPNVETGLVQQRPEIGIMQALESLNDTQVNEFLCGKAPLNLSMRLGDHMMLIQLQLSTVSGAKPPPASHPSPPVRPPSLTQASRNLQHTLRRLSADVFSGRSESTSRRGSVYSGTFSGALNPALQDPKGRPRRDVATIVHILNDLLCSAPELRRVSRQGEEQSETIQQQIDEPTPSSISEDQNSRTRGKLEHLRLVMGERRERRRQRKQKPYSLPQSDTDTVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1K697</accession>
    <name>A0A1Y1K697_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">small monomeric GTPase</fullName>
            <ecNumber evidence="3">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PPYR_11338</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Ras family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="3"/>
    <dbReference type="EMBL" id="GEZM01094054">
        <property type="protein sequence ID" value="JAV55968.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01094053">
        <property type="protein sequence ID" value="JAV55970.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0794499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1K697"/>
    <dbReference type="FunCoup" id="A0A1Y1K697">
        <property type="interactions" value="877"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1K697"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04139">
        <property type="entry name" value="RalA_RalB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000203">
        <property type="entry name" value="Putative ras-related protein ral-a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0636">Prenylation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="JAV55968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAB0794499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="201" mass="23264" checksum="3659743E6CB4C17B" modified="2017-08-30" version="1">MSKKPVTQPALHKVIMVGSGGVGKSALTLQFMYDEFVEDYEPTKADSYRKKILLDGEEVQIDILDTAGQEDYAAIRDNYFRSGEGFLCIFSITEDESFQATQDFREQILRVKNDENIPFLLVGNKCDLEERRKVTYQEASDRAKQWGVTYVETSAKTREHVDKVFFDLMREIRARKMEENKTNNGRGKDKNKRKKIKCVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1K7T0</accession>
    <name>A0A1Y1K7T0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="3 8">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PPYR_02533</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the FKBP-type PPIase family. FKBP1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="3 8"/>
    <dbReference type="EMBL" id="GEZM01092425">
        <property type="protein sequence ID" value="JAV56561.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0805563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1K7T0"/>
    <dbReference type="FunCoup" id="A0A1Y1K7T0">
        <property type="interactions" value="1066"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1K7T0"/>
    <dbReference type="OrthoDB" id="1902587at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033017">
        <property type="term" value="C:sarcoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000008">
        <property type="entry name" value="Peptidylprolyl isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050689">
        <property type="entry name" value="FKBP-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10516:SF443">
        <property type="entry name" value="FK506-BINDING PROTEIN 59-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10516">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="9">
        <location>
            <begin position="20"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="JAV56561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0805563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="108" mass="11648" checksum="0000C7344A5E7AA4" modified="2017-08-30" version="1">MGVHVNSLSPGDGQTFPKTGQTVVVHYTGTLENGTKFDSSRDRGVPFKFRIGKGEVIKGWDEGVAQLSVGQRATLTCSPDYAYGSRGHPGIIPPNSTLIFDVELIRVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1K7W4</accession>
    <name>A0A1Y1K7W4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein RFT1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PPYR_13248</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">Intramembrane glycolipid transporter that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. RFT1 could mediate the translocation of the cytosolically oriented intermediate DolPP-GlcNAc2Man5, produced by ALG11, into the ER lumen where dolichol-linked oligosaccharides assembly continues. However, the intramembrane lipid transporter activity could not be confirmed in vitro.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Endoplasmic reticulum membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the RFT1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01089450">
        <property type="protein sequence ID" value="JAV57493.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1K7W4"/>
    <dbReference type="FunCoup" id="A0A1Y1K7W4">
        <property type="interactions" value="1383"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1K7W4"/>
    <dbReference type="OrthoDB" id="9979195at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034203">
        <property type="term" value="P:glycolipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007594">
        <property type="entry name" value="RFT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13117">
        <property type="entry name" value="ENDOPLASMIC RETICULUM MULTISPAN TRANSMEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13117:SF5">
        <property type="entry name" value="PROTEIN RFT1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04506">
        <property type="entry name" value="Rft-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="177"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="341"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="381"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="416"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="439"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="472"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="504"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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    </evidence>
    <sequence length="122" mass="13211" checksum="01B466EE2038565D" modified="2017-08-30" version="1">MARKNQEINGGDCQGKSRSPKNHNAVYFNNSSPKVDDKVFSRLSPSRTPPSAGSPGTSPRMSPGVLAGHYAGCKWSEPPLPSALPRPPPHWMSTSPVKCVFRSDKPSQPDAYQLKVLLNVQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1KN26</accession>
    <name>A0A1Y1KN26_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Arrestin C-terminal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_14470</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arrestin family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01081527">
        <property type="protein sequence ID" value="JAV61610.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1KN26"/>
    <dbReference type="InParanoid" id="A0A1Y1KN26"/>
    <dbReference type="OrthoDB" id="2333384at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF176">
        <property type="entry name" value="ARRESTIN DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0716">Sensory transduction</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="3">
        <location>
            <begin position="181"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="JAV61610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0792511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="317" mass="35820" checksum="179D74E92EBD2E5D" modified="2017-08-30" version="1">MGDKCEVFLEKEEYAPGEIINGRVECNFASQNKVKGIRLKISGDAKVFWKISAFTYRRAQEVFFETDLDLLETDEMTFPPGTYTYPFTYTLPSTVPSSMMEGDPTYKKTVASYVVPFNLVDVYYGCVQYIIKVTIERSWSTNISIEKLFKVMSSLDLTTISGLEKSYELSIGKRPSSLFKDTGPITATIQMPRSGYVPGEKLPFSVYVKNASSIDIQYIQFKFVQGFVFHAEQSTKSIDTMMGEEFMLKESDVAVGNERSWKLELVVPSMFLGNYSHCSVIKNFWELRGEICLPFPNPAFNVSVPITVGSVALTKRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1KQR8</accession>
    <name>A0A1Y1KQR8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Mediator of RNA polymerase II transcription subunit 8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Mediator complex subunit 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">MED8</name>
        <name evidence="14" type="ORF">PPYR_01993</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 11">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 11">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the Mediator complex subunit 8 family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01082928">
        <property type="protein sequence ID" value="JAV61217.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0805023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1KQR8"/>
    <dbReference type="FunCoup" id="A0A1Y1KQR8">
        <property type="interactions" value="1671"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1KQR8"/>
    <dbReference type="OrthoDB" id="150687at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1710:FF:000001">
        <property type="entry name" value="Mediator of RNA polymerase II transcription subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019364">
        <property type="entry name" value="Mediatior_Med8_fun/met"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13074">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13074:SF9">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10232">
        <property type="entry name" value="Med8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0010">Activator</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 11" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="199"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="201"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="248"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="JAV61217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAB0805023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="263" mass="28987" checksum="5E46A02B9E13A1CE" modified="2017-08-30" version="1">MKMQQAREEKQLESALDSIIQRINDLKASVASMIFKVENEYETLNWPTFLDNYALLSGHLTSLSKLMNHDKCPPLRNLTVLPLMLSPERDEQLVQGTEGRVITFAHDLVPDYLRTKLEPLAENKMLQLEHKATNLTYDNAQKQATAYQKVVSHVWDIVNKAREEWEVESSARGNTQQNSSVADTHVLVAAVGMGKGLKMVTNPNGQPNPSSGGMMVAPQGPGRPGAPPGQGQIPQPPQGMMSKAPSAIKTNIKSATQIHPYGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1KS03</accession>
    <name>A0A1Y1KS03_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Apoptosis inhibitor 5/fibroblast growth factor 2-interacting factor 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_07621</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
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    <reference evidence="5" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the API5 family.</text>
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    <dbReference type="EMBL" id="GEZM01077209">
        <property type="protein sequence ID" value="JAV63368.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="ARM repeat"/>
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    <proteinExistence type="inferred from homology"/>
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        <location>
            <begin position="448"/>
            <end position="518"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="466"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009515"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="JAV63368.1"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAB0799741.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
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    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
    <sequence length="518" mass="58529" checksum="FEE3A58C388D3B04" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1KSU1</accession>
    <name>A0A1Y1KSU1_PHOPY</name>
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        <recommendedName>
            <fullName evidence="3">small monomeric GTPase</fullName>
            <ecNumber evidence="3">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">PPYR_04124</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
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                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
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            <dbReference type="DOI" id="10.1038/srep38556"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="21 22" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
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                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">1611_PpyrPB1</strain>
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    <reference evidence="21" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">1611_PpyrPB1</strain>
            <tissue evidence="21">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
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        <subcellularLocation>
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            <location evidence="13">Golgi stack membrane</location>
            <topology evidence="13">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 19">Belongs to the small GTPase superfamily. SAR1 family.</text>
    </comment>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
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    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
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        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
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    </dbReference>
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        <property type="entry name" value="RE74312P"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
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        <property type="match status" value="1"/>
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    <keyword evidence="15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 19" id="KW-0653">Protein transport</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 19" id="KW-0813">Transport</keyword>
    <feature type="binding site" evidence="17">
        <location>
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            <end position="34"/>
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        <ligand>
            <name>GTP</name>
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    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
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    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="73"/>
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        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
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    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="129"/>
            <end position="132"/>
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        <ligand>
            <name>GTP</name>
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    </feature>
    <feature type="binding site" evidence="16">
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        <ligand>
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    <feature type="binding site" evidence="16">
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        <ligand>
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    </feature>
    <feature type="binding site" evidence="16">
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        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:37565"/>
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    <feature type="binding site" evidence="16">
        <location>
            <position position="175"/>
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        <ligand>
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    </feature>
    <feature type="binding site" evidence="16">
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        <ligand>
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    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007507"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR606687-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR606687-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU003926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="JAV63260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAB0801938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="193" mass="22004" checksum="027982C9B7F3333F" modified="2017-08-30" version="1">MFIWDWFTGVLGYLGLWKKSGKLLFLGLDNAGKTTLLHMLKDDRLAQHVPTLHPTSEELSIGNMRFTTFDLGGHTQARRVWKDYFPAVDAIVFLIDAFDRQRFVESKKELDLLLTDETLSNCPVLILGNKIDLPGAASEDELRTSYVLYNQTTGKGKVSRQDLPGRPLELFMCSVLKRQGYGEGFRWLAQYID</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1KUC4</accession>
    <name>A0A1Y1KUC4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">SLC41A/MgtE integral membrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PPYR_05623</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC41A transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01076223">
        <property type="protein sequence ID" value="JAV63800.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000003">
        <property type="protein sequence ID" value="KAB0801269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1KUC4"/>
    <dbReference type="InParanoid" id="A0A1Y1KUC4"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.20:FF:000001">
        <property type="entry name" value="Solute carrier family 41 member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.20">
        <property type="entry name" value="SLC41 divalent cation transporters, integral membrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006667">
        <property type="entry name" value="SLC41_membr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036739">
        <property type="entry name" value="SLC41_membr_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045349">
        <property type="entry name" value="SLC41A1-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16228">
        <property type="entry name" value="DIVALENT CATION TRANSPORTER SOLUTE CARRIER FAMILY 41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16228:SF7">
        <property type="entry name" value="SLC41A_MGTE INTEGRAL MEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01769">
        <property type="entry name" value="MgtE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161093">
        <property type="entry name" value="MgtE membrane domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="56"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="137"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="175"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="278"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="375"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="404"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="449"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="SLC41A/MgtE integral membrane" evidence="11">
        <location>
            <begin position="101"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="SLC41A/MgtE integral membrane" evidence="11">
        <location>
            <begin position="312"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="JAV63800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAB0801269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="477" mass="51897" checksum="43B4345CBE45F418" modified="2017-08-30" version="1">MNKLNQNRISEKSSGFSSNVTDPSSSTTNDGIRKLSQTLIETSTCEENEIQMQETYFSVAIQVFIPFLIAGFGMVFAGLVLDRIQHLPVFEEITELVILTPPLLGLKGNLEMTLASRLSTHANLGRMDSFKQKWNMITANLMLTQCQAIVVGLLGSLVAVIMGGIRSNEVELAHVLLICASSLLTVSLASFVLGLVTSGAVVLSRLCHINPDNVATPIAASLGDITSLALLSWVSTALYDCIGKRDWVAPFIIVGYITVIPCWVWVAKHNVRTREVLYHGWTPILGAMLISSMGGLILDIMVSKFEGIARFQPLMNGVGGNLVAVHASRISTSLHKEQELGLCSSSLKTEEESIIFISPVSGFCGKEAHSRTARVLMTMVVPGHLIFLYTIVHIKGGNTSLSTIFVLAYLCAAVVQVATLLYVAYIMIHWMWKRKIDPDNSAIPYLTSMGDLLGISLLALAFQFLHLVIGNDSQLGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1KWX9</accession>
    <name>A0A1Y1KWX9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Gamma-interferon-inducible lysosomal thiol reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_14964</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GILT family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01075225">
        <property type="protein sequence ID" value="JAV64195.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000684">
        <property type="protein sequence ID" value="KAB0790877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1KWX9"/>
    <dbReference type="FunCoup" id="A0A1Y1KWX9">
        <property type="interactions" value="202"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1KWX9"/>
    <dbReference type="OrthoDB" id="958254at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016671">
        <property type="term" value="F:oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004911">
        <property type="entry name" value="Interferon-induced_GILT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13234">
        <property type="entry name" value="GAMMA-INTERFERON INDUCIBLE LYSOSOMAL THIOL REDUCTASE GILT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13234:SF69">
        <property type="entry name" value="GILT-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03227">
        <property type="entry name" value="GILT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036312526" description="Gamma-interferon-inducible lysosomal thiol reductase" evidence="3">
        <location>
            <begin position="19"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="JAV64195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0790877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="246" mass="27610" checksum="BF30EE19E74D826B" modified="2017-08-30" version="1">MIPIYFLTILSGVLCVTGEKVPVTVYYESLCPDSRKFFTTQLHPLLQTNLSKWIDLTLVPYGKSNQTQVSPEQWEFTCHHGPYECHGNKIHGCALNVIEKSAKTPDGYGFNPITLDFLNCLMNATTKGMNPDDGSDKYVFPIDDCARDNSVPNYMWIENCVNHIDGSKYLAALGDQTVKFQSPLLSVPTIVFNNRYSKQESNDAFKSFGQILCKHIATPPEECHNRALILNASFLLVALTFGKFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1KXJ2</accession>
    <name>A0A1Y1KXJ2_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">alanine transaminase</fullName>
            <ecNumber evidence="8">2.6.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PPYR_10994</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-alanine + 2-oxoglutarate = pyruvate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:19453"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="2.6.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid degradation; L-alanine degradation via transaminase pathway; pyruvate from L-alanine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.2" evidence="8"/>
    <dbReference type="EMBL" id="GEZM01074930">
        <property type="protein sequence ID" value="JAV64405.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1KXJ2"/>
    <dbReference type="FunCoup" id="A0A1Y1KXJ2">
        <property type="interactions" value="520"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1KXJ2"/>
    <dbReference type="OrthoDB" id="1732682at2759"/>
    <dbReference type="UniPathway" id="UPA00528">
        <property type="reaction ID" value="UER00586"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004021">
        <property type="term" value="F:L-alanine:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042853">
        <property type="term" value="P:L-alanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1970:FF:000001">
        <property type="entry name" value="Alanine aminotransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000012">
        <property type="entry name" value="alanine aminotransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000010">
        <property type="entry name" value="Alanine aminotransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045088">
        <property type="entry name" value="ALAT1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11751">
        <property type="entry name" value="ALANINE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11751:SF29">
        <property type="entry name" value="ALANINE TRANSAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="10">
        <location>
            <begin position="146"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="JAV64405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAB0796933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="539" mass="60177" checksum="7E1826ECBCB59E1B" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1KY87</accession>
    <name>A0A1Y1KY87_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Trafficking protein particle complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PPYR_08199</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">May play a role in vesicular transport from endoplasmic reticulum to Golgi.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Golgi apparatus</location>
            <location evidence="1 8">cis-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the TRAPP small subunits family. BET3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01070645">
        <property type="protein sequence ID" value="JAV66359.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01070644">
        <property type="protein sequence ID" value="JAV66362.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01070643">
        <property type="protein sequence ID" value="JAV66364.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01070642">
        <property type="protein sequence ID" value="JAV66365.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01070641">
        <property type="protein sequence ID" value="JAV66367.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01070640">
        <property type="protein sequence ID" value="JAV66370.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1KY87"/>
    <dbReference type="FunCoup" id="A0A1Y1KY87">
        <property type="interactions" value="2307"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1KY87"/>
    <dbReference type="OrthoDB" id="10262857at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14942">
        <property type="entry name" value="TRAPPC3_bet3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1380.20:FF:000013">
        <property type="entry name" value="Trafficking protein particle complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.20">
        <property type="entry name" value="Trafficking protein particle complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016721">
        <property type="entry name" value="Bet3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007194">
        <property type="entry name" value="TRAPP_component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13048">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04051">
        <property type="entry name" value="TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018293">
        <property type="entry name" value="TRAPP_I_complex_Bet3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 8" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7 8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR018293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="JAV66359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0797205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="178" mass="19889" checksum="D1B01FA1799E5B07" modified="2017-08-30" version="1">MARSSSRFDTKKVNSELVTLTYGSLVAQMVKDVENPDDVNKQLDRLGYNMGIRLVEDFLAKTGSGRCLDLKDTADKIQTAFRMYLGVQPNVANWSPAGDEFSFIIDSNPLTDLVELPEDLKGLRYCNIICGAIRGALEMVQLDIQSWIVQDQLKGDANTEIRVKFIRKLEDAIPAGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1L723</accession>
    <name>A0A1Y1L723_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein hairless</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_00961</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01062775">
        <property type="protein sequence ID" value="JAV69483.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1L723"/>
    <dbReference type="InParanoid" id="A0A1Y1L723"/>
    <dbReference type="OrthoDB" id="2328924at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="418"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="113"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="JAV69483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0803991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="443" mass="50513" checksum="72583F1EEFCAD308" modified="2017-08-30" version="1">MRPRGRSPSTKCYEMRIVEASAIPNWTKCSKMTEEGHRINGNTDGGAVVPKDETSKNAYNQGGRLKFFKDGKFILELERAQDGERVSWVSVPRKTYWPPQGNAPSIPTYRQESNASLSVSDDNSSIQSSPWQRDHSWKQATPRRNQSKEMTFFYYHLKKFSNWRTCKNRRRPYAIINHVDSILRTIKTEIKSEPTEQISVCNKVTNKLRERSSLMAVVQMLIDKCASSTPPRSEIVVSPRKRFLREMEKDKLQVDDACQKRSRNKSVVSGSAPPVTIKVESPIRLNGLTSGMTEDMRAPRNCSYSITSLLAEDRSRCSPNDSPSNFSPVPQYCSPHEDPWYSESVDRLRSIELSQVDKRTLAAYSSYPYMSPYMYPYSLPPYYSSGVYGRNYMVPPIYPPQPMAVSIRHETPSCSWSADASKDLDHRDDSITDMPLNLSKHAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LDC5</accession>
    <name>A0A1Y1LDC5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="21 22">Serine/threonine-protein kinase RIO3</fullName>
            <ecNumber evidence="4 22">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">PPYR_13632</name>
    </gene>
    <organism evidence="24">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="25 26" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">1611_PpyrPB1</strain>
            <tissue evidence="25">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="25" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="25">1611_PpyrPB1</strain>
            <tissue evidence="25">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 22">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="20">Interacts with CASP10. Interacts with IRF3; RIOK3 probably mediates the interaction of TBK1 with IRF3. Associated with 40S pre-ribosomal particles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 22">Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4 22"/>
    <dbReference type="EMBL" id="GEZM01058838">
        <property type="protein sequence ID" value="JAV71652.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0794012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1LDC5"/>
    <dbReference type="FunCoup" id="A0A1Y1LDC5">
        <property type="interactions" value="1003"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1LDC5"/>
    <dbReference type="OrthoDB" id="205248at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05146">
        <property type="entry name" value="RIO3_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000200">
        <property type="entry name" value="Serine/threonine-protein kinase RIO3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051272">
        <property type="entry name" value="RIO-type_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018934">
        <property type="entry name" value="RIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000687">
        <property type="entry name" value="RIO_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018935">
        <property type="entry name" value="RIO_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017406">
        <property type="entry name" value="Ser/Thr_kinase_Rio3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45723">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01163">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038146">
        <property type="entry name" value="Ser/Thr_PK_RIO3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00090">
        <property type="entry name" value="RIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01245">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="16" id="KW-0391">Immunity</keyword>
    <keyword evidence="9" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="13 22" id="KW-0418">Kinase</keyword>
    <keyword evidence="15 22" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 22" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 22" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7 22" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="10 22" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RIO kinase" evidence="23">
        <location>
            <begin position="217"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00064322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00068351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRNR" id="PIRNR038146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="SMART" id="SM00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="JAV71652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="KAB0794012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="529" mass="60962" checksum="38379827E8AD6BA5" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LFJ0</accession>
    <name>A0A1Y1LFJ0_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_02498</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01057198">
        <property type="protein sequence ID" value="JAV72394.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0805528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1LFJ0"/>
    <dbReference type="InParanoid" id="A0A1Y1LFJ0"/>
    <dbReference type="OrthoDB" id="5978988at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.20">
        <property type="entry name" value="Pheromone/general odorant binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006170">
        <property type="entry name" value="PBP/GOBP"/>
    </dbReference>
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        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01395">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00708">
        <property type="entry name" value="PhBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036312544" evidence="1">
        <location>
            <begin position="16"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="JAV72394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0805528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="140" mass="16859" checksum="A3754519E77E377F" modified="2017-08-30" version="1">MKLLILFALLSSSFASWKFDMDPEILHDWLGMMQPYTEQCHKETDVDKEIVYNAFMKMDLPEDYKEFNCFAKCMYTRLGFYYPETGKFDRELMVKRIKGMTKHIAEDCYEHRYHTEEEDRCKHMYNSVVCAIKKLSKMVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LWJ9</accession>
    <name>A0A1Y1LWJ9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Paired domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PPYR_12645</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">1611_PpyrPB1</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">1611_PpyrPB1</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the paired homeobox family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01045110">
        <property type="protein sequence ID" value="JAV77913.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1LWJ9"/>
    <dbReference type="FunCoup" id="A0A1Y1LWJ9">
        <property type="interactions" value="20"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1LWJ9"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007365">
        <property type="term" value="P:periodic partitioning"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009791">
        <property type="term" value="P:post-embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00131">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000679">
        <property type="entry name" value="Homeobox protein aristaless"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000003">
        <property type="entry name" value="Paired box protein Pax-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000031">
        <property type="entry name" value="Paired box protein Pax-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043182">
        <property type="entry name" value="PAIRED_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001523">
        <property type="entry name" value="Paired_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043565">
        <property type="entry name" value="PAX_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45636">
        <property type="entry name" value="PAIRED BOX PROTEIN PAX-6-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45636:SF3">
        <property type="entry name" value="PROTEIN GOOSEBERRY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00292">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00027">
        <property type="entry name" value="PAIREDBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00351">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00034">
        <property type="entry name" value="PAIRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51057">
        <property type="entry name" value="PAIRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6 10 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 10 11" id="KW-0371">Homeobox</keyword>
    <keyword evidence="9 10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0563">Paired box</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Paired" evidence="14">
        <location>
            <begin position="16"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="13">
        <location>
            <begin position="179"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="10">
        <location>
            <begin position="181"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="151"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="284"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="284"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="JAV77913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAB0793025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="402" mass="44772" checksum="52120FADF400DA70" modified="2017-08-30" version="1">MALNMAPYFTGYPFQGQGRVNQLGGVFINGRPLPNHIRLRIVELAASGVRPCVISRQLRVSHGCVSKILNRYQETGSIRPGVIGGSKPRVATVEVETRIEQLKRENPGIFSWEIRDKLIKEGICDKNNAPSVSSISRLLRGGRKDEVDRKNHSIDGILGPNCSGDESDTESEPGIPLKRKQRRSRTTFTGEQLEALERAFGRTQYPDVYTREELAQKTKLTEARVQVWFSNRRARLRKQLNSQQLNAFNTMSLQSAFPVQHQYSDPAFNQASWPQQSYALGASTLTPPSTLSHSSTTTNTTATSTPSYTTYNSTSIEPNVLNPTNQLGYMSQISPNQHGVGTQQSAVWNRHSSNNKMAENLSSWHENYSFFAGSHYGAHSPGEAKSGYPYFGTMEMCASRVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1M8V0</accession>
    <name>A0A1Y1M8V0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Tetraspanin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PPYR_05234</name>
        <name evidence="7" type="ORF">PPYR_14846</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GEZM01040019">
        <property type="protein sequence ID" value="JAV81000.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000873">
        <property type="protein sequence ID" value="KAB0790707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000003">
        <property type="protein sequence ID" value="KAB0800880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1M8V0"/>
    <dbReference type="FunCoup" id="A0A1Y1M8V0">
        <property type="interactions" value="302"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1M8V0"/>
    <dbReference type="OrthoDB" id="5845060at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282:SF452">
        <property type="entry name" value="LD03691P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00259">
        <property type="entry name" value="TMFOUR"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="JAV81000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0790707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0800880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="222" mass="24778" checksum="EC638D5D0ECA3A13" modified="2017-08-30" version="1">MCGGFTCSKNALISLNILYILVSFILIGVAVYGRAASLVTNLPIVGGILACGVILFLISLLGLVGAVKHHQVMLFFYMVILFLLFLIQFSVACACLGVNMEQQEQLAEQGWEKMDNNTRMEVQQAFGCCGFDEKSTDNRKMDHPSCDALKCCANPEKSCHCSSCMNKWQTTINYAFKLCGWIGLFFSFTEVVGMFLTRHYRNLTDPDEKVATAIFPSHNFIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1MDI8</accession>
    <name>A0A1Y1MDI8_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_01766</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01035973">
        <property type="protein sequence ID" value="JAV83068.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1MDI8"/>
    <dbReference type="FunCoup" id="A0A1Y1MDI8">
        <property type="interactions" value="588"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1MDI8"/>
    <dbReference type="OrthoDB" id="285674at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06428">
        <property type="entry name" value="M1P_guanylylT_A_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056729">
        <property type="entry name" value="GMPPB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050486">
        <property type="entry name" value="Mannose-1P_guanyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22572">
        <property type="entry name" value="SUGAR-1-PHOSPHATE GUANYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25087">
        <property type="entry name" value="GMPPB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleotidyl transferase" evidence="2">
        <location>
            <begin position="3"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Mannose-1-phosphate guanyltransferase C-terminal" evidence="3">
        <location>
            <begin position="284"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="JAV83068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0804796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="422" mass="46729" checksum="B124D75F514F7662" modified="2017-08-30" version="1">MLKAVILIGGPQKGTRFRPLSLDIPKPLFPVAGLPVIQHHIEACITIDELKEILLIGYYPAAQIQQFVGDMQQQYNINIRYLQEFTALGTAGGLYHFRDQIRCGNPDAFFVMNGDVCADFPLQELYTFHKQKGALVTIMGTEATRQQSLKYGCMATNKATQEVTHYVEKPSSYVSTLINCGIYVFSLEIFSTIGEAFNIKQQDIYRNGNGSKETGFIQLEQEILTPLAGGGRLFALQVTTWWSQLKTAGSAIYANRHYLELYHKKHSERLLHTVNDKGNAVCNIIPDVYIHPTATVHPSATLGPNVSIGPGVMIGPGVRIRESIILADAVIENHSLVLHSIIGQNSKVGRWARVEGTPSDPDPNKPFAKMENPPLFNHDGRLNPSITILGGFVSVPSETILLNSVVLPHKELTRSFKNEIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1ME42</accession>
    <name>A0A1Y1ME42_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Scavenger receptor class B member 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PPYR_07771</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CD36 family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01036247">
        <property type="protein sequence ID" value="JAV82860.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KAB0799891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1ME42"/>
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    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1ME42"/>
    <dbReference type="OrthoDB" id="514335at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005044">
        <property type="term" value="F:scavenger receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002159">
        <property type="entry name" value="CD36_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11923:SF114">
        <property type="entry name" value="FI02050P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11923">
        <property type="entry name" value="SCAVENGER RECEPTOR CLASS B TYPE-1 SR-B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01130">
        <property type="entry name" value="CD36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01609">
        <property type="entry name" value="CD36FAMILY"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="444"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="JAV82860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0799891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="482" mass="54426" checksum="B5E61490D9125622" modified="2017-08-30" version="1">MACSKKCGVCTLLSLGGVFVTIGVVLALFWTTLYNGILTTELVLTNSSKSYQLWKDTPIPIYMKMYMFNWTNAEEVVRSKWTVKPQMHECGPYVFSEHHVRVNVTWNENSTVTFRQVKTWQFVQSMSNGSLNDSITNINPITIVIGEKVKNLPTLVKEAINFLLVDMHENLYFTRTVDDLIFKGVEDPILDKLDKFHVKIPFKKFGWFYARNNSASYDGTFTMYTGKSDMDSLGELSLWNGMPNTTAYKGKCGDVNGTTGELWPPVSNREHVEIFASDICGQLSFEHNGTESVLNVEGKKFIGTDFTFDNGTKYPAQSCYRGDEVIASGARSISVCRFGSPAYMSYPHFYLADPSYLQKVTGLKPNKTEHESHLTIEPVTGITLAAKVQLQLNLRIESIKGMSIFDNVPPMYMPMIWFSQVAELPQKYCSMTTLLVGLGSVGHYVGWTVFAFGLLMSIVGFILIYRNRTEDEEEDHLIENES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1MIT3</accession>
    <name>A0A1Y1MIT3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7153 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_04683</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01035547">
        <property type="protein sequence ID" value="JAV83187.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1MIT3"/>
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        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1MIT3"/>
    <dbReference type="OrthoDB" id="6060890at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055577">
        <property type="entry name" value="DUF7153"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22198">
        <property type="entry name" value="FERM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22198:SF1">
        <property type="entry name" value="FERM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23672">
        <property type="entry name" value="DUF7153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7153" evidence="2">
        <location>
            <begin position="243"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="JAV83187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0802497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="427" mass="48042" checksum="708EDB81D741EC0F" modified="2017-08-30" version="1">MNLMFRKNFREQKSVGGGKGTLNKSSANRHINKRINREQGYTPIEEQYYRTHLFFSPRTRSTYNINEVEEPRCGPMTGTVGNPSSLQSISPPMSDADLPQPLVIRNPSDPLMRWPNTPTKSTPTRQVNFNRANEGHGEIARTLSDLDRDCFIIPVHSLDRFLPAGVPLPKTTTTGGDNAENNNQGGLNVLQIPDPKLCVLCHLMSPLEAIDPILESPLAQPILRQRMAAAELITEISQAKPAATGMLLANMERNAEFPFISYYIINSAQTNPVIFYNNLRSASLKKFDPRTIRYTAAHTLDLYTEVATICRPPINDSSTSLTKINTATTGYIISVYKVFEGDDREKFERNWLYWTGARMIYRYLPREAGLKRIALHKSLSPKGDKMYLLVCECSNLLKDVTVCALLLPALRARLTGYTGLFRPLQTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1MKT1</accession>
    <name>A0A1Y1MKT1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">HIG1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PPYR_15146</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GEZM01031222">
        <property type="protein sequence ID" value="JAV84965.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01001249">
        <property type="protein sequence ID" value="KAB0790457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1MKT1"/>
    <dbReference type="FunCoup" id="A0A1Y1MKT1">
        <property type="interactions" value="229"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1MKT1"/>
    <dbReference type="OrthoDB" id="10003563at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097250">
        <property type="term" value="P:mitochondrial respirasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007667">
        <property type="entry name" value="Hypoxia_induced_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050355">
        <property type="entry name" value="RCF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12297:SF3">
        <property type="entry name" value="HIG1 DOMAIN FAMILY MEMBER 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12297">
        <property type="entry name" value="HYPOXIA-INDUCBILE GENE 1 HIG1 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04588">
        <property type="entry name" value="HIG_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51503">
        <property type="entry name" value="HIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="64"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="HIG1" evidence="8">
        <location>
            <begin position="5"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="JAV84965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0790457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="100" mass="10960" checksum="AAB4FC4FB3F966A2" modified="2017-08-30" version="1">MSSTTAMANPPPAFFHDESQSERLARKSKDAPFFPIAIGICAVTCAYGAYMFKRRGKMSPSIFLMQLRVTAQGLAVGTLTLGLGYTMYNEHFGKAKSEKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1MT59</accession>
    <name>A0A1Y1MT59_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Mitochondrial 2-oxodicarboxylate carrier</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Solute carrier family 25 member 21</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">PPYR_07072</name>
    </gene>
    <organism evidence="22">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="23 24" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">1611_PpyrPB1</strain>
            <tissue evidence="23">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">1611_PpyrPB1</strain>
            <tissue evidence="23">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Transports dicarboxylates across the inner membranes of mitochondria by a counter-exchange mechanism. Can transport 2-oxoadipate (2-oxohexanedioate), 2-oxoglutarate, adipate (hexanedioate), glutarate, and to a lesser extent, pimelate (heptanedioate), 2-oxopimelate (2-oxoheptanedioate), 2-aminoadipate (2-aminohexanedioate), oxaloacetate, and citrate. Plays a central role in catabolism of lysine, hydroxylysine, and tryptophan, by transporting common metabolite intermediates (such as 2-oxoadipate) into the mitochondria, where it is converted into acetyl-CoA and can enter the citric acid (TCA) cycle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>2-oxoadipate(in) + 2-oxoglutarate(out) = 2-oxoadipate(out) + 2-oxoglutarate(in)</text>
            <dbReference type="Rhea" id="RHEA:71739"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57499"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>2-oxoheptanedioate(in) + 2-oxoglutarate(out) = 2-oxoheptanedioate(out) + 2-oxoglutarate(in)</text>
            <dbReference type="Rhea" id="RHEA:71755"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:72701"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-2-aminoadipate(in) + 2-oxoglutarate(out) = L-2-aminoadipate(out) + 2-oxoglutarate(in)</text>
            <dbReference type="Rhea" id="RHEA:71747"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:58672"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>citrate(in) + 2-oxoglutarate(out) = citrate(out) + 2-oxoglutarate(in)</text>
            <dbReference type="Rhea" id="RHEA:71763"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>glutarate(in) + 2-oxoglutarate(out) = glutarate(out) + 2-oxoglutarate(in)</text>
            <dbReference type="Rhea" id="RHEA:71751"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30921"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>heptanedioate(in) + 2-oxoglutarate(out) = heptanedioate(out) + 2-oxoglutarate(in)</text>
            <dbReference type="Rhea" id="RHEA:71759"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:36165"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>hexanedioate(in) + 2-oxoglutarate(out) = hexanedioate(out) + 2-oxoglutarate(in)</text>
            <dbReference type="Rhea" id="RHEA:71743"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17128"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 21">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01024975">
        <property type="protein sequence ID" value="JAV87660.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1MT59"/>
    <dbReference type="InParanoid" id="A0A1Y1MT59"/>
    <dbReference type="OrthoDB" id="434783at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051752">
        <property type="entry name" value="Mito_2-oxodicarb_carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46356">
        <property type="entry name" value="MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46356:SF1">
        <property type="entry name" value="MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 20 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 21" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="20">
        <location>
            <begin position="25"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="20">
        <location>
            <begin position="126"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="20">
        <location>
            <begin position="224"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00036018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00046087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="JAV87660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KAB0799192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="320" mass="34996" checksum="069A926E096D8B68" modified="2017-08-30" version="1">MLLIVTIFLNFKIYIKITMSKKVLKQAALQTAAGGSAGFTEVCIMHPLDLIKTRLQIQTVKPNANPNDPTYYTGIVDCVKKMYKHEGLGSFWKGIIPPIMAETPKRALKFVSFEQYKRLLMFDGKATPLTFVMAGTLCGITEAFVANPFEVVKVTLQASRGSGKETKGTWATTKEIVKQHGLGLKGLNKGLSATIWRHGLFNLFYFGIYNNLKAVLPPAKDPTGEFLKTVGCGFISGVIGSIANIPFDVAKSRIQGPQPVPGQVKYKSLFGTLAIVYKEEGFGALYKGLLPKVLRLGPGGAIMIVVFDKVYGYLTVTFPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1N6R9</accession>
    <name>A0A1Y1N6R9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PPYR_02366</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="GEZM01013352">
        <property type="protein sequence ID" value="JAV92630.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0805396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1N6R9"/>
    <dbReference type="InParanoid" id="A0A1Y1N6R9"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08308">
        <property type="entry name" value="Death_Tube"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000754">
        <property type="entry name" value="Interleukin-1 receptor-associated kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029397">
        <property type="entry name" value="Tube_Death"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27001">
        <property type="entry name" value="OS01G0253100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27001:SF931">
        <property type="entry name" value="OS11G0664100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14786">
        <property type="entry name" value="Death_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="445"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="380"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="380"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="474"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="JAV92630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAB0805396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="728" mass="79579" checksum="6D9F0A16752EEE35" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1NE57</accession>
    <name>A0A1Y1NE57_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">CDGSH iron-sulfur domain-containing protein 2 homologue</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PPYR_04214</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
        <text evidence="10">Binds 1 [2Fe-2S] cluster.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the CISD protein family. CISD2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01008084">
        <property type="protein sequence ID" value="JAV94864.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01008083">
        <property type="protein sequence ID" value="JAV94865.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1NE57"/>
    <dbReference type="FunCoup" id="A0A1Y1NE57">
        <property type="interactions" value="1328"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1NE57"/>
    <dbReference type="OrthoDB" id="449252at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.5.90:FF:000001">
        <property type="entry name" value="CDGSH iron-sulfur domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.90">
        <property type="entry name" value="CDGSH iron-sulfur domain, mitoNEET-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045131">
        <property type="entry name" value="CISD1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018967">
        <property type="entry name" value="FeS-contain_CDGSH-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019610">
        <property type="entry name" value="FeS-contain_mitoNEET_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042216">
        <property type="entry name" value="MitoNEET_CISD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13680">
        <property type="entry name" value="CDGSH IRON-SULFUR DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13680:SF5">
        <property type="entry name" value="CDGSH IRON-SULFUR DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10660">
        <property type="entry name" value="MitoNEET_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09360">
        <property type="entry name" value="zf-CDGSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00704">
        <property type="entry name" value="ZnF_CDGSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 10" id="KW-0408">Iron</keyword>
    <keyword evidence="8 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Iron-binding zinc finger CDGSH type" evidence="11">
        <location>
            <begin position="78"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU369084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="JAV94865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAB0802028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="131" mass="14464" checksum="82A26C5D7A8361F0" modified="2017-08-30" version="1">MVVGHLVKVTLPNYLAGLPIPDTFTGWFKLGIKDWLSLIPPTAAVAGLTYVGYLAFCPHGRPKPDGRVNPCVRKDNPKVVDSFDVEDITEKVCFCRCWRSKNWPYCDGAHGKHNKETGDNVGPVVVNVKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N3ZY74</accession>
    <name>A0A5N3ZY74_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_15693</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01002064">
        <property type="protein sequence ID" value="KAB0790015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N3ZY74"/>
    <dbReference type="InParanoid" id="A0A5N3ZY74"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0790015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="85" mass="9559" checksum="03D3103B324F2FB1" modified="2020-02-26" version="1" fragment="single">MSIAALLEAAEYLERREREAEHGYASTLPMPDDLRNVYKRPKTKKSQGNRTSHNELEKNRISGYLQFDIGMGPPKKLKGAALSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N3ZZJ3</accession>
    <name>A0A5N3ZZJ3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_15121</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01001212">
        <property type="protein sequence ID" value="KAB0790483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N3ZZJ3"/>
    <dbReference type="InParanoid" id="A0A5N3ZZJ3"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="3">
        <location>
            <begin position="4"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="1">
        <location>
            <begin position="4"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="38"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="41"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="58"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0790483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="86" mass="10399" checksum="9E2FC2AAE643B162" modified="2020-02-26" version="1">MENQQISTSAFLNYLAQYRRENPNKSAKDIARDGGAMWRGMTEEERQPFKDMADRARRLQRTKVKRSKRRKTLRRKSKRNSRKKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A0A9</accession>
    <name>A0A5N4A0A9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_15666</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000812">
        <property type="protein sequence ID" value="KAB0790736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A0A9"/>
    <dbReference type="InParanoid" id="A0A5N4A0A9"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1800.10">
        <property type="entry name" value="His-Me finger endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038563">
        <property type="entry name" value="Endonuclease_7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511">
        <property type="entry name" value="PROTEIN CBG23764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511:SF12">
        <property type="entry name" value="RHO TERMINATION FACTOR N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="2"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0790736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1252" mass="144856" checksum="9277D1B870590A6C" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A0D5</accession>
    <name>A0A5N4A0D5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ARID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PPYR_15494</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000784">
        <property type="protein sequence ID" value="KAB0790766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A0D5"/>
    <dbReference type="InParanoid" id="A0A5N4A0D5"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.60">
        <property type="entry name" value="ARID DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045147">
        <property type="entry name" value="ARI3A/B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001606">
        <property type="entry name" value="ARID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036431">
        <property type="entry name" value="ARID_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15348">
        <property type="entry name" value="AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN ARID DOMAIN- CONTAINING PROTEIN DEAD RINGER PROTEIN B-CELL REGULATOR OF IGH TRANSCRIPTION BRIGHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15348:SF0">
        <property type="entry name" value="PROTEIN DEAD RINGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01388">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46774">
        <property type="entry name" value="ARID-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51011">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="ARID" evidence="5">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0790766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="52" mass="5804" checksum="130E0F13A478DF71" modified="2020-02-26" version="1" fragment="single">MAKAVLDLYELYNLVIARGGLVDVINKKLWQEIIKGLRLPSSITSAAFTLRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A0K9</accession>
    <name>A0A5N4A0K9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Putative nuclease HARBI1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Harbinger transposase-derived nuclease</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PPYR_15222</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Transposase-derived protein that may have nuclease activity. Does not have transposase activity.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HARBI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000691">
        <property type="protein sequence ID" value="KAB0790850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A0K9"/>
    <dbReference type="InParanoid" id="A0A5N4A0K9"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026103">
        <property type="entry name" value="HARBI1_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF289">
        <property type="entry name" value="DDE TNP4 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02086">
        <property type="entry name" value="PUTNUCHARBI1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="13">
        <location>
            <begin position="108"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAB0790850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="317" mass="36461" checksum="C4B9E7C565E02E40" modified="2020-02-26" version="1">MRKATAERIIQMIEGQIAPFINNRGSPISATVQFLATVRYLAKGAYGVDIADQHGLSQPSLSNIIKRVSQALAAHRHRFINFPTAEESHQVKADFYRFANCPSVIGAIDGTHVKIKCPGGDYPLLYLNRKGYYSLNVQVVCDAKCKIRDIVARWRGSTHDSRIWNECHLRRRFMHGEIDGVLVGDNGYQCSRYILTPLLNPQTNAEQRYNTAHIRTRNVIERTFGIWKNRFRCFFNGLNLQLETTKAVIVATAILHNLIIQERLDNDDSSDDEYDDDNDRVIYHNDGREHVQGNLFRARYIDTHFNEILYKMCQKCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A2L0</accession>
    <name>A0A5N4A2L0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Fatty acyl-CoA reductase</fullName>
            <ecNumber evidence="10">1.2.1.84</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PPYR_03336</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a long-chain fatty acyl-CoA + 2 NADPH + 2 H(+) = a long-chain primary fatty alcohol + 2 NADP(+) + CoA</text>
            <dbReference type="Rhea" id="RHEA:52716"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:77396"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="EC" id="1.2.1.84"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the fatty acyl-CoA reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.84" evidence="10"/>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A2L0"/>
    <dbReference type="FunCoup" id="A0A5N4A2L0">
        <property type="interactions" value="107"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A2L0"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102965">
        <property type="term" value="F:alcohol-forming long-chain fatty acyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080019">
        <property type="term" value="F:alcohol-forming very long-chain fatty acyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035336">
        <property type="term" value="P:long-chain fatty-acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05236">
        <property type="entry name" value="FAR-N_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09071">
        <property type="entry name" value="FAR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000143">
        <property type="entry name" value="Fatty acyl-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026055">
        <property type="entry name" value="FAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033640">
        <property type="entry name" value="FAR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011:SF45">
        <property type="entry name" value="FATTY ACYL-COA REDUCTASE CG8306-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011">
        <property type="entry name" value="MALE STERILITY PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0521">NADP</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="353"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="446"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="Thioester reductase (TE)" evidence="11">
        <location>
            <begin position="18"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00052530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAB0791536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="491" mass="55059" checksum="0C3F4E88ED5CEB94" modified="2020-02-26" version="1">MSSTQSVASWYANKNVFITGGSGFLGLCLLEKLLRCVPNIGDIYLLLRPKKGKSVDARLEDLKKNSVFETLLQSKSVEQCFSRVKAIAGDIAEDGLGISASDRQILVGNVNVIFHSAATLDFAEGFKQTVQINLLGTRQVLALAKECRNFAAFVHVSSAYVNSFQTESEEIFYPLKGDPEDIIAVVEKSSEKELEERSVELLNGHANTYTYTKQMAEKEVEKMEKVFPCAIVRPSMIVGAWKEPVPGWTASKNGPQGFLMGASKGIIRRLPVSKELIYDYIPVDVVVNQLIVAAFRAGSTSSKKLEIFHCTSSTRKPFTWSSVYGQINSYLHTYPLKSAVWYPHLKLLPSVTWFRISALFVHFLPAIILDGLTKLAGGRPILMRLHRRQHAKLQEWLTSEDQVMFNLDLSSLRWPEFFGDLARGVRVYLNHEKMSNIEAARGKDTMLMVLHLALQLAIYSLLWYTFACLTGLSMSKSMLVVPVFYVLFSFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A3G1</accession>
    <name>A0A5N4A3G1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PPYR_03642</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A3G1"/>
    <dbReference type="InParanoid" id="A0A5N4A3G1"/>
    <dbReference type="OrthoDB" id="4142200at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000249">
        <property type="entry name" value="facilitated trehalose transporter Tret1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050549">
        <property type="entry name" value="MFS_Trehalose_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021:SF24">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="299"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="335"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="395"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="431"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="464"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="42"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0791842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="529" mass="59099" checksum="8B4460D50F8D1881" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A3L6</accession>
    <name>A0A5N4A3L6_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_03706</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A3L6"/>
    <dbReference type="InParanoid" id="A0A5N4A3L6"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0791906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="157" mass="17903" checksum="1EADABD8880C2B9C" modified="2020-02-26" version="1">MWPELISSTMATTRSANVLAVYAFTLILGLSAQIHKMDDVDNRLETASDSPKNVIDFVLFSNLLRNYSFYDPRPMETSWGINVAVDYGYDDFSASSSSQEGPPEEDYRYETPTKLNKKKAYGNRDRRSVGRLLSLRNKYDDPKVTAEYYDKKGGQDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A4B1</accession>
    <name>A0A5N4A4B1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PPYR_14106</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A4B1"/>
    <dbReference type="FunCoup" id="A0A5N4A4B1">
        <property type="interactions" value="25"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A4B1"/>
    <dbReference type="OrthoDB" id="3934656at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008395">
        <property type="term" value="F:steroid hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006805">
        <property type="term" value="P:xenobiotic metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20651">
        <property type="entry name" value="CYP15A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000036">
        <property type="entry name" value="CYtochrome P450 family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050182">
        <property type="entry name" value="Cytochrome_P450_fam2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300:SF376">
        <property type="entry name" value="CYTOCHROME P450 15A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300">
        <property type="entry name" value="CYTOCHROME P450 508A4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024381615" description="Cytochrome P450" evidence="10">
        <location>
            <begin position="22"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="432"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0792147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="488" mass="56567" checksum="2F1DE186DB1CDD47" modified="2020-02-26" version="1">MLALVLVFVSFILFWLKLSVTKPRNFPPGPKWLPMVGSLPFLKRLSIKLGSQHRALTEMSKQFKTNVLGLKLGGEIMISVEDYETIREVLTCEQYDQRPNNFFIRLRTLGTCKGITCAEGKLWTEQRSFVVRHLRNIGLGKKIMDLKIQDEIANLFKIIDERVEVQIAKLLPFAIINILWSMVAGKRIASENQLLDIINKRTKAFDMSGGVLAQQPWLRYIIPERSGYNLIKKLNKELKAFLMETINEHHETWTEDNQEDFIYSFITEMKKMNDPQSSFTDEQLLIVCLDLFVGGFTTTSSTLDFFFLMMVLYPDVQAKIQANLDETFDDNYQIEFTDRHRLPYIDAVIKEVQRYRTILPVIGPRRSTKEMNLSGYTIPKDTTILINLAPTYMSKEIWGDPENFRPERFLDESGELVSHPQFLPFGLGKRKCLGDAFARGCLFIFTTEFLRRYEIRPVDEKNLPSAEPLPGLVASPRPYFAKFTRRRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A4L3</accession>
    <name>A0A5N4A4L3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_14200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A4L3"/>
    <dbReference type="FunCoup" id="A0A5N4A4L3">
        <property type="interactions" value="719"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A4L3"/>
    <dbReference type="OrthoDB" id="10249433at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052651">
        <property type="term" value="P:monoacylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006660">
        <property type="term" value="P:phosphatidylserine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277">
        <property type="entry name" value="ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277:SF194">
        <property type="entry name" value="FI04476P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="135"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0792241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="363" mass="40910" checksum="D059CD0ECBFF24DE" modified="2020-02-26" version="1">MADAEGTSGLIGSMRVVVPLGIVLMLHSLNVISTCTLSALLLAFLLIFVVGPFTYRYSHRFRQSTIFLNFVTIPLQADVKNPGKYGLKAVLNFYLMTDDDITLGVWHIAHEDAIDSCDGQDIEHYRSALGDGRDVVLYCHGNAGNRSVPHRVEMYAVLRRQFHVIAFDYRSYGDSSPVPPSERGLVADSLFIFKWVRGLAKGNVFVWGHSLGTAISTHMLDVAAASDLRSVGLILESPFNNMQDELRLHPFTKLFRSLPWFRYCVLEPVKSSNLLFQTDEHINNVDCPILILHAKDDVIVPFQLGLKLYKSAKENRLKTQGEVRFHQFEESLWFGHKYICRSPDLGEIIRSFVVDCLTTNGTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A5K5</accession>
    <name>A0A5N4A5K5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phospholipase A2</fullName>
            <ecNumber evidence="3">3.1.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Phosphatidylcholine 2-acylhydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PPYR_14564</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">1611_PpyrPB1</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.4" evidence="3"/>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A5K5"/>
    <dbReference type="FunCoup" id="A0A5N4A5K5">
        <property type="interactions" value="73"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A5K5"/>
    <dbReference type="OrthoDB" id="10059604at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050482">
        <property type="term" value="P:arachidonate secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04704">
        <property type="entry name" value="PLA2_bee_venom_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.90.10:FF:000002">
        <property type="entry name" value="Phospholipase A2 group III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.90.10">
        <property type="entry name" value="Phospholipase A2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016090">
        <property type="entry name" value="PLA2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033113">
        <property type="entry name" value="PLA2_histidine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036444">
        <property type="entry name" value="PLipase_A2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12253">
        <property type="entry name" value="RH14732P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05826">
        <property type="entry name" value="Phospholip_A2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48619">
        <property type="entry name" value="Phospholipase A2, PLA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00118">
        <property type="entry name" value="PA2_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024386125" description="Phospholipase A2" evidence="13">
        <location>
            <begin position="29"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipase A2-like central" evidence="14">
        <location>
            <begin position="46"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF05826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAB0792605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="180" mass="20763" checksum="73B1EB3FC5EA447C" modified="2020-02-26" version="1">MKSIALVTIVTLVLRFWASAMFLDNTRGRYETDTNDDGRLPNWFAIFPGTKWCGAGNISANNEDLGIAADTDKCCRTHDFCNDTIEAGGTRHNLTNDAFYTRLVCDCDYDFYDCLKNVSSKVSNNVGLIYFNILGTQCFREDYPIVACIKYEYTPRKKCVEYAYDTTQDKRYQWFDVPRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A5U4</accession>
    <name>A0A5N4A5U4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Probable ATP-dependent RNA helicase DDX52</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PPYR_14665</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">1611_PpyrPB1</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DEAD box helicase family. DDX52/ROK1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A5U4"/>
    <dbReference type="FunCoup" id="A0A5N4A5U4">
        <property type="interactions" value="1703"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A5U4"/>
    <dbReference type="OrthoDB" id="360161at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17957">
        <property type="entry name" value="DEADc_DDX52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000759">
        <property type="entry name" value="probable ATP-dependent RNA helicase DDX52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044764">
        <property type="entry name" value="DDX52/Rok1_DEADc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF15">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="17">
        <location>
            <begin position="121"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="152"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="339"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="537"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="12">
        <location>
            <begin position="121"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAB0792706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="559" mass="62925" checksum="B4DA2649393292A1" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-06-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A6C1</accession>
    <name>A0A5N4A6C1_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_14767</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A6C1"/>
    <dbReference type="InParanoid" id="A0A5N4A6C1"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024429764" evidence="1">
        <location>
            <begin position="18"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0792808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="151" mass="16095" checksum="E461E6B1F93404E2" modified="2020-02-26" version="1">MFPQIFVVCALAAFASAGILEPSLSTLKFSVEEPSSVLRLVSPAITKTEFVPGSYSSSFRTDVIAPRLRLTETPAVSFSVPDSTIALARLEKIVPAVEKVERLVPSIAIDSAHLLRTKLDLVEPLPIARGYVGHAGLSIPVTRGVATGHVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A7A3</accession>
    <name>A0A5N4A7A3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PPYR_12758</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A7A3"/>
    <dbReference type="FunCoup" id="A0A5N4A7A3">
        <property type="interactions" value="25"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A7A3"/>
    <dbReference type="OrthoDB" id="6581954at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035725">
        <property type="term" value="P:sodium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10332">
        <property type="entry name" value="SLC6sbd-B0AT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF037979">
        <property type="entry name" value="Na_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF182">
        <property type="entry name" value="TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
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        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0915">Sodium</keyword>
    <keyword evidence="5 9" id="KW-0769">Symport</keyword>
    <keyword evidence="4 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="164"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="249"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="279"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="332"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="475"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="513"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="547"/>
            <end position="567"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="588"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="631"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="69"/>
            <end position="81"/>
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    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
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    <feature type="binding site" evidence="8">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
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        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
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        </ligand>
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            <position position="108"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
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    <feature type="binding site" evidence="8">
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            <position position="335"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
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    <feature type="binding site" evidence="8">
        <location>
            <position position="367"/>
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        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
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        </ligand>
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    <feature type="binding site" evidence="8">
        <location>
            <position position="484"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
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    <feature type="binding site" evidence="8">
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        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
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    <feature type="binding site" evidence="8">
        <location>
            <position position="488"/>
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        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAB0793138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="721" mass="80097" checksum="4CF181ADB5B7FB89" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A847</accession>
    <name>A0A5N4A847_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">RING finger protein unkempt</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PPYR_13102</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the unkempt family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="FunCoup" id="A0A5N4A847">
        <property type="interactions" value="1538"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A847"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="RING-HC_UNK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040594">
        <property type="entry name" value="UNK_Znf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057295">
        <property type="entry name" value="UNK_Znf_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057296">
        <property type="entry name" value="UNK_Znf_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045234">
        <property type="entry name" value="Unkempt-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14493:SF50">
        <property type="entry name" value="RING FINGER PROTEIN UNKEMPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14493">
        <property type="entry name" value="UNKEMPT FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23261">
        <property type="entry name" value="zf-CCCH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25427">
        <property type="entry name" value="zf-CCCH_UNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23035">
        <property type="entry name" value="zf-CCCH_UNK-like_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18384">
        <property type="entry name" value="zf_CCCH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="12">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="12">
        <location>
            <begin position="228"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="12">
        <location>
            <begin position="270"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="695"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="8">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="8">
        <location>
            <begin position="228"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="8">
        <location>
            <begin position="270"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="322"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="580"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="335"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="363"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAB0793482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="738" mass="82927" checksum="01E5F1963CA5FB79" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A8W7</accession>
    <name>A0A5N4A8W7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aldehyde dehydrogenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PPYR_13383</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A8W7"/>
    <dbReference type="InParanoid" id="A0A5N4A8W7"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006081">
        <property type="term" value="P:aldehyde metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000004">
        <property type="entry name" value="Aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012394">
        <property type="entry name" value="Aldehyde_DH_NAD(P)"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570:SF16">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE TYPE III, ISOFORM Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="5">
        <location>
            <begin position="5"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0793763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="331" mass="37355" checksum="5B3F0449D3518294" modified="2020-02-26" version="1">MSLSAEEVVTRARGAFNTGRTKPVEFREQQLKNLLRLYEENAPRLAEVLKADLAKHKQESIAMEIAFNTSNIRNTLAELRKWIGPERPPKYFMNMSDEVLIYNDPYGVVLVIGAWNYPLQVTLGPLVDAIAAGNCVVLKPSELAPETEKVIAELVPKYLDNDCYQVFRGGPEDTQELLKQRFDYIFFTGSSRIGKLVHAAANEHITPTTLELGGKSPCILHESADLEIAAHRILWGKWINSGQTCIAPDYLLCTREVGRKFISSAESILRKWYGRDPQKSEDFARIINVKHFKRLCRLLESGKVVVGGKTDEAERFIQLTVLDGVKERLIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A9R7</accession>
    <name>A0A5N4A9R7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PPYR_13618</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A9R7"/>
    <dbReference type="InParanoid" id="A0A5N4A9R7"/>
    <dbReference type="OrthoDB" id="5565075at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24271:SF23">
        <property type="entry name" value="CHYMASE 2, MAST CELL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24271">
        <property type="entry name" value="KALLIKREIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024283176" description="Peptidase S1 domain-containing protein" evidence="4">
        <location>
            <begin position="20"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="5">
        <location>
            <begin position="10"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0793998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="264" mass="29327" checksum="94520046C4451FAC" modified="2020-02-26" version="1">MPRLLVVLAFVGCISVAKSLSPEASEIATKHAIPYQANLRIEVIDSDIRYCAGTLISPNYVLTAANCGDGASKILVDMGVDDVENRQEPTWRTYLGDAFIAHPLYNKSTGYHDIGLIHLFEPAEINDAIQLVTLPDHRYKNLAGKMARISGWGNVNASTDLDHRLLRYADIPIGSHSNCLPQFPYPNFAQLCPAQSDSYFQTYDFGAPLMLKDVQIGIATATSFDNGIETNPQIYTRVDPYLSWIMNNTDVTIEQQKDHRLAVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AA39</accession>
    <name>A0A5N4AA39_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dynein regulatory complex protein 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PPYR_13816</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Flagellum axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DRC10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0794196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AA39"/>
    <dbReference type="InParanoid" id="A0A5N4AA39"/>
    <dbReference type="OrthoDB" id="536093at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042815">
        <property type="entry name" value="DRC10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31598:SF1">
        <property type="entry name" value="DYNEIN REGULATORY COMPLEX PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31598">
        <property type="entry name" value="IQ DOMAIN-CONTAINING PROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0969">Cilium</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0282">Flagellum</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="351"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0794196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="370" mass="42894" checksum="81576C20B0F9EABB" modified="2020-02-26" version="1">MPDFERVKKSRNEDDDVEVQASRVLRVMNNAIAKLKIATCLPAFISDDSLLLRKYLRNDEVDFIQVTCEQYISPLGQQARMTKKNSVAHPRMALALDMIWNNMELRNLALENHGDLADPTALPLIDSIHSLTQLTETKLGQTAKEERLSRKQLRTAWYENAEMQKQLSELTTKIERQGDEGESKIVQSMQLVRSYQNKILSHIQTVKRTIKERVENSEKTMYGESTASLVRQANLSSDAKTVTNQYEAVLSQHLNVEKKLRAKRLKVETQLANWLSKYDADMGERQAEFEHLDDIYNRQKESMDLLRVMVAEQQAEYEALWTERLEEGLANLRVNRAARIIQRCWRKYRAKKLAAKRGKSDKKKKKKKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AAD6</accession>
    <name>A0A5N4AAD6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">receptor protein serine/threonine kinase</fullName>
            <ecNumber evidence="5">2.7.11.30</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">PPYR_13897</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">1611_PpyrPB1</strain>
            <tissue evidence="22">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.30" evidence="5"/>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0794277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AAD6"/>
    <dbReference type="FunCoup" id="A0A5N4AAD6">
        <property type="interactions" value="809"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AAD6"/>
    <dbReference type="OrthoDB" id="69842at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004675">
        <property type="term" value="F:transmembrane receptor protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071363">
        <property type="term" value="P:cellular response to growth factor stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23596">
        <property type="entry name" value="TFP_LU_ECD_Tkv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000018">
        <property type="entry name" value="Receptor protein serine/threonine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.60.10:FF:000021">
        <property type="entry name" value="Receptor protein serine/threonine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000055">
        <property type="entry name" value="Receptor protein serine/threonine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.60.10">
        <property type="entry name" value="CD59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000472">
        <property type="entry name" value="Activin_recp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003605">
        <property type="entry name" value="GS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045860">
        <property type="entry name" value="Snake_toxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000333">
        <property type="entry name" value="TGFB_receptor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23255:SF68">
        <property type="entry name" value="RECEPTOR PROTEIN SERINE_THREONINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23255">
        <property type="entry name" value="TRANSFORMING GROWTH FACTOR-BETA RECEPTOR TYPE I AND II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01064">
        <property type="entry name" value="Activin_recp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08515">
        <property type="entry name" value="TGF_beta_GS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00467">
        <property type="entry name" value="GS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57302">
        <property type="entry name" value="Snake toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51256">
        <property type="entry name" value="GS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-0675">Receptor</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="135"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="GS" evidence="21">
        <location>
            <begin position="180"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="20">
        <location>
            <begin position="220"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAB0794277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="522" mass="59808" checksum="0C56792E7F641B50" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AAW5</accession>
    <name>A0A5N4AAW5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein TsetseEP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_11309</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0794470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AAW5"/>
    <dbReference type="InParanoid" id="A0A5N4AAW5"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33964:SF1">
        <property type="entry name" value="RE45066P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33964">
        <property type="entry name" value="RE45066P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024368354" description="Protein TsetseEP domain-containing protein" evidence="1">
        <location>
            <begin position="16"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0794470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="220" mass="24887" checksum="F89384DA2A2D2C2D" modified="2020-02-26" version="1">MKYVLALFTICNVLALPPCNEDILMKYLANMQIINPEMIINLSTLDSLPKLCDKIAENLNQLSTYLQSCTPFEHSLFTKLIQGVDTLYNKLCTNTKFARDFINHHNCLHTSRDAFVACNGPEDWIENSNNEIICDSYKRILNCYYNETLAHCGNLAAKNMAELTTEVINSVLVIKCDNINQTYKGVLETDSGGSIATFQLKMLVSILILKFSLTMSLYFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AB52</accession>
    <name>A0A5N4AB52_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_11327</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0794488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AB52"/>
    <dbReference type="InParanoid" id="A0A5N4AB52"/>
    <dbReference type="OrthoDB" id="6334967at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012464">
        <property type="entry name" value="DUF1676"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21879">
        <property type="entry name" value="FI03362P-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21879:SF25">
        <property type="entry name" value="OSIRIS 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07898">
        <property type="entry name" value="DUF1676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024325333" evidence="1">
        <location>
            <begin position="29"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0794488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="414" mass="46379" checksum="5A1490435D1D1A15" modified="2020-02-26" version="1">MGSLWKHIRSWCMIRILILIHLPHLIQTCVIEMSKLSPLDRELKTYVDDLVKTDSYKIFPGVDIKRNFNVTQDELRSESCRRSREMRSIDDYLKAKLEKYALNHYVRVNLPETARFFQPVEAGKSSFMAGFGMGFLAFALKKMLLPVFIGAQLIKSVLLALFLPSLLGSVGKLLGKGLSTFSGSSGSSGLGHGNNDPVEDFEFKDTSPYNVNSAPDTGTAETGLSINVATSTDKTDTINRFGYGNNMVSYTPYQSESNYYLKKPSVNTDFKVFHKIPPSSLLLTTYDPFYSPLLSRLDAVFQQLGLGNDKSPKTERCREKLVCMMYANPAKYAPYSNLVSAQLSRELNELRKPSSDNPEILRFFRYMKAAKDGQDGEECLAHSGCPSLSADQPNPAIVTTFNEINKLVQARKFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AB57</accession>
    <name>A0A5N4AB57_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PPYR_11391</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0794552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AB57"/>
    <dbReference type="FunCoup" id="A0A5N4AB57">
        <property type="interactions" value="151"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AB57"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001370">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379:SF121">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379">
        <property type="entry name" value="KRAB AND ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="707"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="787"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="814"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="858"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="915"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="943"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="140"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="160"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAB0794552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1166" mass="133565" checksum="496B7E3BFBFCB3BB" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ABY0</accession>
    <name>A0A5N4ABY0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cuticle protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_11676</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0794837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ABY0"/>
    <dbReference type="InParanoid" id="A0A5N4ABY0"/>
    <dbReference type="OrthoDB" id="8188035at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062129">
        <property type="term" value="C:chitin-based extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008010">
        <property type="term" value="F:structural constituent of chitin-based larval cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050468">
        <property type="entry name" value="Cuticle_Struct_Prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380">
        <property type="entry name" value="CUTICLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380:SF196">
        <property type="entry name" value="CUTICULAR PROTEIN 72EA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0193">Cuticle</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024358025" description="Cuticle protein 6" evidence="2">
        <location>
            <begin position="19"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0794837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="341" mass="36189" checksum="BFB00AB31EAE7127" modified="2020-02-26" version="1">MELLRLFIALLSIWGVSSSGVTIGITPYSLPIYSQYHAQDILGQYAYGYATPTSTKSETKSANGVTVGGYSYLDSFGILQTVRYFADPIHGFRVAATNLPQDLPDVALAKAQHLAEFQATQSERAAIAAHYTNPIVVPVSQVKKIELLPTPVQDLPEVVKARAEHLAKFQATQAEHAALAAHSATPVPVQDLPEVARAKAEHLATFEAIKARDASQVVVSPLPAHISAPVVAPAAIPYYSYVPAIPLLPSSQYHAQDGIGQYSYGYVGPLSSKSEAKTADGITRGGYSYLDARGEIQTVSYISDPVNGFRVAATNLPVAPEVLLKGPSASAKIVAPVAPTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ABY6</accession>
    <name>A0A5N4ABY6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_11665</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0794826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ABY6"/>
    <dbReference type="InParanoid" id="A0A5N4ABY6"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="3">
        <location>
            <begin position="10"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0794826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="182" mass="20824" checksum="C0CF509BC6A851E9" modified="2020-02-26" version="1">MFEQGRYGDAVLVGDSGYACNRYMMTPLDNCYTAAENLYNESQIRTRNPIERLFGVWKRRFPVTVVGLRVSVPNCFAIIVATVALHNIAVRAGEQVPHDDDELHLPAPWDVLLAQGQMGNDPQVQAAPRRENPNHRWRRAIIDNYFTILTQQELYDRQQEAERARQEEIPQAVTGRAALYNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-06-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ACN4</accession>
    <name>A0A5N4ACN4_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_04340</name>
        <name evidence="1" type="ORF">PPYR_11910</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0795071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ACN4"/>
    <dbReference type="InParanoid" id="A0A5N4ACN4"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0795071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0802154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="145" mass="16784" checksum="6B12D183F7FC7B95" modified="2020-02-26" version="1">MLGYSASSASVFRIQRRAVRIIAGLGYREDCKKSFVKLKILTLPSIYIHECIMSARNNLHLYQTNSMQHSYATRQQNNIILPVTRLKKTRTGTSYYGIKLYNALPLDIRSSDSKTLSKWLKTFLLSQAFFTIDEFFCHKFDNCIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ACU6</accession>
    <name>A0A5N4ACU6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="25">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">PPYR_11992</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">1611_PpyrPB1</strain>
            <tissue evidence="23">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein heavy chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0795153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4ACU6"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.30:FF:000002">
        <property type="entry name" value="Dynein axonemal heavy chain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.1220:FF:000001">
        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002141">
        <property type="entry name" value="Dynein heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.720:FF:000001">
        <property type="entry name" value="dynein heavy chain 7, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.280:FF:000001">
        <property type="entry name" value="dynein heavy chain 7, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.490.20:FF:000001">
        <property type="entry name" value="dynein heavy chain 7, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000049">
        <property type="entry name" value="Dynein, axonemal, heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.20:FF:000006">
        <property type="entry name" value="Dynein, axonemal, heavy chain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000362">
        <property type="entry name" value="Dynein, axonemal, heavy chain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.720">
        <property type="entry name" value="Region D6 of dynein motor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035706">
        <property type="entry name" value="AAA_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041658">
        <property type="entry name" value="AAA_lid_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042219">
        <property type="entry name" value="AAA_lid_11_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054354">
        <property type="entry name" value="DYNC2H1-like_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041466">
        <property type="entry name" value="Dynein_AAA5_ext"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041228">
        <property type="entry name" value="Dynein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043160">
        <property type="entry name" value="Dynein_C_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024743">
        <property type="entry name" value="Dynein_HC_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024317">
        <property type="entry name" value="Dynein_heavy_chain_D4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004273">
        <property type="entry name" value="Dynein_heavy_D6_P-loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22878:SF70">
        <property type="entry name" value="DYNEIN HEAVY CHAIN 2, AXONEMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22878">
        <property type="entry name" value="DYNEIN HEAVY CHAIN 6, AXONEMAL-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12775">
        <property type="entry name" value="AAA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12780">
        <property type="entry name" value="AAA_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12781">
        <property type="entry name" value="AAA_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18198">
        <property type="entry name" value="AAA_lid_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22597">
        <property type="entry name" value="DYN_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17852">
        <property type="entry name" value="Dynein_AAA_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18199">
        <property type="entry name" value="Dynein_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03028">
        <property type="entry name" value="Dynein_heavy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12777">
        <property type="entry name" value="MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0966">Cell projection</keyword>
    <keyword evidence="10" id="KW-0969">Cilium</keyword>
    <keyword evidence="9 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0243">Dynein</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Dynein heavy chain AAA 5 extension" evidence="19">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein 2 heavy chain 1 cytoplasmic ATPase lid" evidence="22">
        <location>
            <begin position="319"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain AAA module D4" evidence="17">
        <location>
            <begin position="483"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain coiled coil stalk" evidence="16">
        <location>
            <begin position="757"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain ATP-binding dynein motor region" evidence="18">
        <location>
            <begin position="1130"/>
            <end position="1348"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain region D6 P-loop" evidence="15">
        <location>
            <begin position="1593"/>
            <end position="1706"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain AAA lid" evidence="20">
        <location>
            <begin position="1742"/>
            <end position="1882"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain C-terminal" evidence="21">
        <location>
            <begin position="1890"/>
            <end position="2187"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="972"/>
            <end position="1034"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF03028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF12777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF12780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF12781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF17852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF18198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF18199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF22597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KAB0795153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="25">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2190" mass="250746" checksum="701CAE1B3959512E" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AD80</accession>
    <name>A0A5N4AD80_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PPYR_12047</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Trehalose transporter subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0795208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AD80"/>
    <dbReference type="InParanoid" id="A0A5N4AD80"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000055">
        <property type="entry name" value="Facilitated trehalose transporter Tret1-2 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050549">
        <property type="entry name" value="MFS_Trehalose_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021:SF46">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="304"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="330"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="364"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="400"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="429"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="16"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0795208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="499" mass="54942" checksum="EDE07C0801FBCD42" modified="2020-02-26" version="1">MGEYMVNPMTSFTTVGLPVHASNIFTKNYEGGTLCAISDGMQYAWTAPIVPILQRPDSPIPITHTDVVWLESIYMIGGMAGIPFIIYSVDRFGRKATILIGTVQHIVSWIMKAFAPSVEFFYVARFISGFAANVDFVAAPMYISEIADKRVRGFLGSSIYVMMLVGILIIYSVAPFVSIPISSAVGCSFLVVELFVFPFMPESPYYLVSKGKMEAAKKSLQKLRTTTKNIDKEFEEILSMVKRRQSEKEKRSYADLFRIRKNRRAVLIVTTLNCAQHFSSYSVILMNLHSILNDAGSMLSSSNAAIIFSALMLCAALSSSILVDRTGRKMLLCASCCLTGLSILSLAMYFAIKNSGHDVAGYSWVPATSAMCYAVFFKCGMGLIPIVLTAELFPSSVKAMGMATASAMYSVSSVVSIYVYQFLSDQFGMHVPFFIFGFSCFLAAFFTIYFIPETKGKTLAEIQLILSSTKSLSTAIRDIKPGSPEYATLLLKQQQESTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ADH6</accession>
    <name>A0A5N4ADH6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Down syndrome cell adhesion molecule</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PPYR_12219</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0795380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A5N4ADH6">
        <property type="interactions" value="210"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4ADH6"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098632">
        <property type="term" value="F:cell-cell adhesion mediator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070593">
        <property type="term" value="P:dendrite self-avoidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="CDD" id="cd20956">
        <property type="entry name" value="IgI_4_Dscam"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd20958">
        <property type="entry name" value="IgI_5_Dscam"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000017">
        <property type="entry name" value="Down syndrome cell adhesion molecule b"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000093">
        <property type="entry name" value="Down syndrome cell adhesion molecule, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000230">
        <property type="entry name" value="Down syndrome cell adhesion molecule, isoform D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000302">
        <property type="entry name" value="Down syndrome cell adhesion molecule, isoform D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000308">
        <property type="entry name" value="Down syndrome cell adhesion molecule, isoform D"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000310">
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        <property type="match status" value="22"/>
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        <property type="entry name" value="DSCAM/DSCAML_C"/>
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        <property type="match status" value="6"/>
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    </dbReference>
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        <property type="match status" value="15"/>
    </dbReference>
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        <property type="match status" value="6"/>
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    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="2200"/>
            <end position="2221"/>
        </location>
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            <end position="121"/>
        </location>
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    <feature type="domain" description="Ig-like" evidence="12">
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    <feature type="domain" description="Ig-like" evidence="12">
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    <feature type="domain" description="Ig-like" evidence="12">
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    <feature type="domain" description="Ig-like" evidence="12">
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            <begin position="1484"/>
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            <begin position="2083"/>
            <end position="2178"/>
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            <begin position="2344"/>
            <end position="2537"/>
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            <end position="2377"/>
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            <end position="2442"/>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAB0795380.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2537" mass="279473" checksum="38922CDD19616CAF" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ADN6</accession>
    <name>A0A5N4ADN6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RNA methyltransferase</fullName>
            <ecNumber evidence="6">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_12187</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="F:snRNA binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040031">
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        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Bin3-like"/>
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        <property type="entry name" value="Bin3_C"/>
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        <property type="entry name" value="7SK SNRNA METHYLPHOSPHATE CAPPING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12315">
        <property type="entry name" value="BICOID-INTERACTING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06859">
        <property type="entry name" value="Bin3"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
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            <begin position="296"/>
            <end position="542"/>
        </location>
    </feature>
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            <begin position="1"/>
            <end position="29"/>
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        <location>
            <begin position="171"/>
            <end position="214"/>
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    </feature>
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        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0795348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="588" mass="67658" checksum="9F6090083EC18E5E" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AE08</accession>
    <name>A0A5N4AE08_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Vacuolar ATPase assembly integral membrane protein VMA21 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_12399</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0795560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AE08"/>
    <dbReference type="FunCoup" id="A0A5N4AE08">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AE08"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070072">
        <property type="term" value="P:vacuolar proton-transporting V-type ATPase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019013">
        <property type="entry name" value="Vma21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31792">
        <property type="entry name" value="VACUOLAR ATPASE ASSEMBLY INTEGRAL MEMBRANE PROTEIN VMA21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31792:SF3">
        <property type="entry name" value="VACUOLAR ATPASE ASSEMBLY INTEGRAL MEMBRANE PROTEIN VMA21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09446">
        <property type="entry name" value="VMA21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="2" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="25"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0795560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="108" mass="12180" checksum="91BC6284D9C1EB58" modified="2020-02-26" version="1">MDNREVVNDNEPLIPAHTRQAAKAIALLLFYSFLMFTLPFAAFFGTKYVLKDSFGIDGYANTVWSVIASVVTVNLVILAYAYYAYHDPEYDNDGNRIDTVDVTKSKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AEP7</accession>
    <name>A0A5N4AEP7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">LITAF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PPYR_09854</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Late endosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Lysosome membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CDIP1/LITAF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0795793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AEP7"/>
    <dbReference type="InParanoid" id="A0A5N4AEP7"/>
    <dbReference type="OrthoDB" id="5599753at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006629">
        <property type="entry name" value="LITAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037519">
        <property type="entry name" value="LITAF_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23292:SF6">
        <property type="entry name" value="FI16602P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23292">
        <property type="entry name" value="LIPOPOLYSACCHARIDE-INDUCED TUMOR NECROSIS FACTOR-ALPHA FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10601">
        <property type="entry name" value="zf-LITAF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00714">
        <property type="entry name" value="LITAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51837">
        <property type="entry name" value="LITAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="281"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="LITAF" evidence="10">
        <location>
            <begin position="243"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="49"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="59"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0795793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="327" mass="35585" checksum="1525307867B71F86" modified="2020-02-26" version="1">MSEDTNYEPAILPPVDDANQETETSPNEPGPSGLNFTTQTSVIITVDSLENESSSSSSATIAPVSTTTQTTECTRHSRRKSGIFRFIKAKSEGNLAEQVQDRQRINASWSQRLVGIRPPCHENIQLSNGPVSAAASQTHEDDAQDSEVGGVLGRYYRSLVTGANSNNSPSQVSSFFYIAPPITGAPPSYSAIMRMDERRLHETTRSGITMQPSAPFIAPRPPPSYTESLGITTTASRGLELYAPSNISIGDFVWGAHPTPVVCHMCEQVVLSLVRTRISTFTHIVAAVFCMFGCWPCCFIPYFIDSCKNVTHHCPNCNAILGMYTPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AFB5</accession>
    <name>A0A5N4AFB5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">LITAF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_10062</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AFB5"/>
    <dbReference type="InParanoid" id="A0A5N4AFB5"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006629">
        <property type="entry name" value="LITAF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10601">
        <property type="entry name" value="zf-LITAF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00714">
        <property type="entry name" value="LITAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51837">
        <property type="entry name" value="LITAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="LITAF" evidence="2">
        <location>
            <begin position="58"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0796001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="171" mass="18684" checksum="AA7B95440178E603" modified="2020-02-26" version="1">MGPAAKCRLCGDALLYTPSKVANLGEHLYCGHSKASLTNFSIEHATSLSNSSLDSSITKRMYKTTVETWKPGIAVLTCPSCGKTGHPIVRKQQNKITHSSLGAICLLGCWPLCFLPFMLGGSNTMNIHCKFCGQYLGTFDRKSGRMQTFDNNCLETKPPVNSYTCDCDCKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AFI6</accession>
    <name>A0A5N4AFI6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">VM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_10161</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AFI6"/>
    <dbReference type="InParanoid" id="A0A5N4AFI6"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024275693" description="VM domain-containing protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0796100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="87" mass="8956" checksum="6F29BD8285AB52ED" modified="2020-02-26" version="1">MFKLVALLALFAVVNAGLIGHGAIGHDAFIAHAAPIAFAHHDASSYANHNSISLHPVPIAVPHAAPIVHAAPIAHFGIAHGHGHHGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AFU8</accession>
    <name>A0A5N4AFU8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Frizzled-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PPYR_10245</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">1611_PpyrPB1</strain>
            <tissue evidence="20">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor Fz/Smo family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AFU8"/>
    <dbReference type="FunCoup" id="A0A5N4AFU8">
        <property type="interactions" value="212"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AFU8"/>
    <dbReference type="OrthoDB" id="10053709at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042813">
        <property type="term" value="F:Wnt receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017147">
        <property type="term" value="F:Wnt-protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035567">
        <property type="term" value="P:non-canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15035">
        <property type="entry name" value="7tmF_FZD5_FZD8-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07456">
        <property type="entry name" value="CRD_FZ5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000262">
        <property type="entry name" value="Frizzled 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.2000.10:FF:000004">
        <property type="entry name" value="Frizzled class receptor 8a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2000.10">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015526">
        <property type="entry name" value="Frizzled/SFRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000539">
        <property type="entry name" value="Frizzled/Smoothened_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020067">
        <property type="entry name" value="Frizzled_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036790">
        <property type="entry name" value="Frizzled_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11309">
        <property type="entry name" value="FRIZZLED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11309:SF126">
        <property type="entry name" value="FRIZZLED-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01534">
        <property type="entry name" value="Frizzled"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01392">
        <property type="entry name" value="Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00489">
        <property type="entry name" value="FRIZZLED"/>
    </dbReference>
    <dbReference type="SMART" id="SM00063">
        <property type="entry name" value="FRI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01330">
        <property type="entry name" value="Frizzled"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63501">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50038">
        <property type="entry name" value="FZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="11 14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="10 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 17" id="KW-0732">Signal</keyword>
    <keyword evidence="13" id="KW-0807">Transducer</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024283760" description="Frizzled-2" evidence="17">
        <location>
            <begin position="25"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="255"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="420"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="467"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="522"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="domain" description="FZ" evidence="18">
        <location>
            <begin position="38"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="19">
        <location>
            <begin position="255"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="168"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="43"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="51"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="88"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="119"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAB0796184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="22">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="623" mass="69696" checksum="AB3E6BD65B36A39B" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AH15</accession>
    <name>A0A5N4AH15_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Choline transporter-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_10637</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Choline transporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the CTL (choline transporter-like) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AH15"/>
    <dbReference type="InParanoid" id="A0A5N4AH15"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007603">
        <property type="entry name" value="Choline_transptr-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE (SLC FAMILY 44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385:SF96">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04515">
        <property type="entry name" value="Choline_transpo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="370"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="414"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="514"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="544"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0796576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="642" mass="72186" checksum="6F8506BF6F670EE9" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AH32</accession>
    <name>A0A5N4AH32_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">b(0,+)-type amino acid transporter 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Glycoprotein-associated amino acid transporter b0,+AT1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Solute carrier family 7 member 9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">PPYR_10716</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">1611_PpyrPB1</strain>
            <tissue evidence="21">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-phenylalanine(out) + L-arginine(in) = L-phenylalanine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:71067"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:71068"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-cysteine(out) + L-arginine(in) = L-cysteine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:71071"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:71072"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-cystine(out) + L-arginine(in) = L-cystine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:71075"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:35491"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:71076"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-histidine(out) + L-arginine(in) = L-histidine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:71063"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:71064"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-leucine(out) + L-arginine(in) = L-leucine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:71059"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:71060"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-lysine(out) + L-arginine(in) = L-lysine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:70827"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:70828"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Apical cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AH32"/>
    <dbReference type="InParanoid" id="A0A5N4AH32"/>
    <dbReference type="OrthoDB" id="5982228at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000015">
        <property type="entry name" value="B(0,+)-type amino acid transporter 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF514">
        <property type="entry name" value="B(0,+)-TYPE AMINO ACID TRANSPORTER 1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="316"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="362"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="387"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="422"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="450"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00051814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00051835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00052179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00052732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00074336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00079910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00083296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00093193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAB0796655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="498" mass="54686" checksum="9B42281B55407EF3" modified="2020-02-26" version="1">MTVSEKMTKGDQNGPTENGNGAKAVQLKREMGLFSAVNMILGVIIGSGIFVSSASALNHAGSVGMCIIVWIVCGIISLLGALTFAELGTVVPRSGAEYAFYMDSFGPLHPFWGKLPAFLCSWVYVIALRPAEVAVITLTFAEYACQPLFDYLGMFQKSDKDNVAKLISIVVLGIITFINVTSVKLYVKIQNIFSSFKVIACIVVILGGVYQWCIGNFDNLNTGFEGTKYSAKDIALAFYSGLWAYDGWNAVTTVTEELKDPEKNILRSICISVPIVTFLYVFVNVAYMTALSVPEMVDAPAVAVAFGEKALGPVQFLIPVGVACATFGCALSIQFSVTRICFVSGQDGHMIECLSYVHYKRLTPVPAVVMQGILSFLYIIVGNINELIEFASFLIWVGYGTAMFSLLILRKTQPNAPRPYRVPIWIVIFIMLVAVFLAVIPMVTDPSVKYLFAIGFMLLGAFVYYGFVYRKNRPRIMDKITYAVQVLFEVVPVDSHED</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AII8</accession>
    <name>A0A5N4AII8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Inter-alpha-trypsin inhibitor heavy chain H4-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_08090</name>
        <name evidence="6" type="ORF">PPYR_08093</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AII8"/>
    <dbReference type="InParanoid" id="A0A5N4AII8"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050934">
        <property type="entry name" value="ITIH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013694">
        <property type="entry name" value="VIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10338">
        <property type="entry name" value="INTER-ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10338:SF108">
        <property type="entry name" value="INTER-ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN H4-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08487">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00609">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51468">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036147754" description="Inter-alpha-trypsin inhibitor heavy chain H4-like" evidence="2">
        <location>
            <begin position="28"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="domain" description="VIT" evidence="4">
        <location>
            <begin position="44"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="3">
        <location>
            <begin position="311"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0797096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0797099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="820" mass="89878" checksum="0DC4DB43164FB75E" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-06-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AJM0</accession>
    <name>A0A5N4AJM0_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_08533</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AJM0"/>
    <dbReference type="InParanoid" id="A0A5N4AJM0"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0797540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="57" mass="6487" checksum="7E90E1C8FC74EC2F" modified="2020-02-26" version="1" fragment="single">RDRVVRAFQVLGVDYKVPISCVEIINTTITDEDFQYERSDDSDSTMALSSIEFLNLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AJN7</accession>
    <name>A0A5N4AJN7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 subunit H</fullName>
            <shortName evidence="5">eIF3h</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PPYR_08422</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex. The eIF-3 complex interacts with pix. Interacts with mxt.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eIF-3 subunit H family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AJN7"/>
    <dbReference type="FunCoup" id="A0A5N4AJN7">
        <property type="interactions" value="2159"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AJN7"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08065">
        <property type="entry name" value="MPN_eIF3h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000045">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03007">
        <property type="entry name" value="eIF3h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027524">
        <property type="entry name" value="eIF3h"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045810">
        <property type="entry name" value="eIF3h_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050242">
        <property type="entry name" value="JAMM_MPN+_peptidase_M67A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10410">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19445">
        <property type="entry name" value="eIF3h_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPN" evidence="7">
        <location>
            <begin position="21"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="260"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0797428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="338" mass="38672" checksum="1C31F0DECD1668B8" modified="2020-02-26" version="1">MASRGGQSRRLQENDSTIAFVQADGLAVMKIVKHCHEETASNMDIAQGALLGLVVDNRLEITNCFPFPKHSDDSLDEEEYQLAMMRRLRRVNVDHFHVGWYQSADVGNFLSLPLLESQYHYQTSIEESVVLIYDSQKSSRGFLTLKAYRLTPQAIEMYKEGEFTPETLLKLKVGFENLFVEVPFVIKNSALTNIMMSELSELVPEERGSKFLDLGTASVLEGQLRCLMDRVDELNQEAIKFNRYQQLVSRQQQEKHRWMLKRSQENASRAAKDEPPLPEEDVNKLFRPQPVPPRLNPMIIAGQINTYSQHISQFCSQSLAKLYITQALQNAKESKSNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AJV9</accession>
    <name>A0A5N4AJV9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Aspartate aminotransferase</fullName>
            <ecNumber evidence="13">2.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PPYR_08638</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">1611_PpyrPB1</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(2S)-2-aminobutanoate + 2-oxoglutarate = 2-oxobutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:70223"/>
            <dbReference type="ChEBI" id="CHEBI:16763"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:74359"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="9">
            <dbReference type="Rhea" id="RHEA:70225"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>3-sulfino-L-alanine + 2-oxoglutarate = 3-sulfinopyruvate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:70295"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:61085"/>
            <dbReference type="ChEBI" id="CHEBI:140699"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="11">
            <dbReference type="Rhea" id="RHEA:70297"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:21824"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="EC" id="2.6.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:21825"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-cysteine + 2-oxoglutarate = 2-oxo-3-sulfanylpropanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:17441"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57678"/>
            <dbReference type="EC" id="2.6.1.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:17442"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4 13">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="13">In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.1" evidence="13"/>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AJV9"/>
    <dbReference type="FunCoup" id="A0A5N4AJV9">
        <property type="interactions" value="1259"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AJV9"/>
    <dbReference type="OrthoDB" id="6752799at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120554">
        <property type="term" value="F:2-aminobutanoate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004069">
        <property type="term" value="F:L-aspartate:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047801">
        <property type="term" value="F:L-cysteine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006532">
        <property type="term" value="P:aspartate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000044">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000001">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000796">
        <property type="entry name" value="Asp_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006719">
        <property type="entry name" value="PRK09257.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879:SF55">
        <property type="entry name" value="GLUTAMATE OXALOACETATE TRANSAMINASE 1, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00799">
        <property type="entry name" value="TRANSAMINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="14">
        <location>
            <begin position="29"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00036027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAB0797645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="405" mass="45519" checksum="D70F52A0BBB3D69B" modified="2020-02-26" version="1">MSRFTNVDLGPPIEVFALTRAFTEDSFAQKVNLGVGAYRTDQGKPWVLPVVRDVEKILAADETRNKEYLPVLGMELFSNAATSMLLGHDSPAVLEKRAFGVQCLSGTGALRVGAEFLARQLGHEIFYYSSPSWENHNLVFTNAGFKEARQYRYWCGKTRGLDIEGFLQDLRDAPQNSVIILHACAHNPTGCDPTQDQWKQIADVIEEKHLFPFFDSAYQGFASGDLEKDSWAVRYFISRGFELFCAQSFAKNFGLYNERVGNLTVVLNDLSCQVAVKSQFTLLVRGMYSNPPLHGASIVAYVLNDPKLFEQWKDHICTMSSRIIDMRKALRTALEKINTPGDWSHITTQIGMFSYTGLNEQQSNHMVKKHHIYMLKSGRISMCGVTPSNVEYVAQAINETLTNVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AK54</accession>
    <name>A0A5N4AK54_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Sodium-dependent multivitamin transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PPYR_08677</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AK54"/>
    <dbReference type="FunCoup" id="A0A5N4AK54">
        <property type="interactions" value="79"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AK54"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11492">
        <property type="entry name" value="SLC5sbd_NIS-SMVT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051163">
        <property type="entry name" value="Sodium:Solute_Symporter_SSF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00813">
        <property type="entry name" value="sss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985:SF40">
        <property type="entry name" value="LD47995P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985">
        <property type="entry name" value="SODIUM-COUPLED MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="10" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="230"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="316"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="376"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="422"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="454"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="482"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="543"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAB0797684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="617" mass="67378" checksum="F761E42A29F5AFEA" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AKA5</accession>
    <name>A0A5N4AKA5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed DNA polymerase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_08706</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AKA5"/>
    <dbReference type="InParanoid" id="A0A5N4AKA5"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33568">
        <property type="entry name" value="DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33568:SF3">
        <property type="entry name" value="DNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0797713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="549" mass="62078" checksum="07B2259F018C0B38" modified="2020-02-26" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AKH0</accession>
    <name>A0A5N4AKH0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="6">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_08789</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AKH0"/>
    <dbReference type="InParanoid" id="A0A5N4AKH0"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="248"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="8">
        <location>
            <begin position="3"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0797796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="282" mass="30756" checksum="8A45659C498EA4AF" modified="2020-02-26" version="1">MRTRNGRQISAYLGIPYAKPPIGNLRFRPPVPADPWSGTLNATEPGSACAQGAVIYATPYQGDENCLFLNLYTPQLHKSERRSYAVMVYIHGGGFALDTGNGYGPDYLLDYDVILVTFNYRLSALGFMTTGDENLPANNGLKDQSLAIKWVHENVGAFGGDPKRITLFGESSGGVSVHYHMFSPLTKGLFHAAISQSGTLFSITSIVDPKALISNSKRLSEYVGCPTENHAKMVECLRSVDARNISEAVSIFAVSIYFFSSLYAPVFVGMGLRSCNDLYADH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ALF2</accession>
    <name>A0A5N4ALF2_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aromatic amino acid beta-eliminating lyase/threonine aldolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_09140</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the threonine aldolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ALF2"/>
    <dbReference type="FunCoup" id="A0A5N4ALF2">
        <property type="interactions" value="112"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4ALF2"/>
    <dbReference type="OrthoDB" id="10261951at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008732">
        <property type="term" value="F:L-allo-threonine aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006545">
        <property type="term" value="P:glycine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:L-threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06502">
        <property type="entry name" value="TA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000030">
        <property type="entry name" value="Low-specificity L-threonine aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001597">
        <property type="entry name" value="ArAA_b-elim_lyase/Thr_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023603">
        <property type="entry name" value="Low_specificity_L-TA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041359">
        <property type="entry name" value="GntG_guanitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007825">
        <property type="entry name" value="PRK10534.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48097:SF9">
        <property type="entry name" value="L-THREONINE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48097">
        <property type="entry name" value="L-THREONINE ALDOLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01212">
        <property type="entry name" value="Beta_elim_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017617">
        <property type="entry name" value="Thr_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aromatic amino acid beta-eliminating lyase/threonine aldolase" evidence="6">
        <location>
            <begin position="23"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR017617-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0798147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="387" mass="42593" checksum="C8F61927B4421796" modified="2020-02-26" version="1">MPYNFEEYSECGHVEGTIAHVVDLRSDTITKPTVNMRKAIAIAEVGDDVFGEDPTVNELERRSAELMGKEDGIFLTSGTMCNIIAVMVHCNKRSVEFIAGDKSHLHLFEQGGPAVLAGVQSSIIPNNPDGTFSLEEMESKIRTSNDSHETSTALIVVENTHNLCGGRVLPLEWLDKLAKIAGNYKLPLHMDGARIMNAVVQSKVSAKRIARDMDSVCFCLSKGLSCPVGSVLCGSKSFIKQARRYRKLLGGGMRQVGILAAAGLVALDEMIDRLQIDHDHAYKIAKAISDADSDIVRVDLSAVQTNIVNIHLDTGKITSKTFLEQLAKITETEEVSVKALSFSPSSIRLVLHWEIKHHDVAAVIRKLKFVIKGLHCRRYITYLDVKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AMK8</accession>
    <name>A0A5N4AMK8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 15">NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial</fullName>
            <ecNumber evidence="15">7.1.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PPYR_08452</name>
        <name evidence="19" type="ORF">PPYR_09496</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">1611_PpyrPB1</strain>
            <tissue evidence="19">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">1611_PpyrPB1</strain>
            <tissue evidence="19">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29091"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="7.1.1.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:29092"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 15">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="13">Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme. Interacts with RAB5IF.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Mitochondrion inner membrane</location>
            <topology evidence="15">Peripheral membrane protein</topology>
            <orientation evidence="15">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the complex I 51 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.2" evidence="15"/>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AMK8"/>
    <dbReference type="InParanoid" id="A0A5N4AMK8"/>
    <dbReference type="OrthoDB" id="42889at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1440.230:FF:000001">
        <property type="entry name" value="Mitochondrial NADH dehydrogenase flavoprotein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.600:FF:000001">
        <property type="entry name" value="NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11540:FF:000001">
        <property type="entry name" value="NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11540">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 51kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.230">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 51kDa subunit, iron-sulphur binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050837">
        <property type="entry name" value="ComplexI_51kDa_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001949">
        <property type="entry name" value="NADH-UbQ_OxRdtase_51kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011537">
        <property type="entry name" value="NADH-UbQ_OxRdtase_suF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011538">
        <property type="entry name" value="Nuo51_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037225">
        <property type="entry name" value="Nuo51_FMN-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019575">
        <property type="entry name" value="Nuop51_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037207">
        <property type="entry name" value="Nuop51_4Fe4S-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054765">
        <property type="entry name" value="SLBB_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01959">
        <property type="entry name" value="nuoF_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010120">
        <property type="entry name" value="PRK13596.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11780:SF10">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11780">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE FLAVOPROTEIN 1 NDUFV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01512">
        <property type="entry name" value="Complex1_51K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10589">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22461">
        <property type="entry name" value="SLBB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00928">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142019">
        <property type="entry name" value="Nqo1 FMN-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142984">
        <property type="entry name" value="Nqo1 middle domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140490">
        <property type="entry name" value="Nqo1C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00644">
        <property type="entry name" value="COMPLEX1_51K_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00645">
        <property type="entry name" value="COMPLEX1_51K_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 15" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="15" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 15" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 15" id="KW-0288">FMN</keyword>
    <keyword evidence="10 15" id="KW-0408">Iron</keyword>
    <keyword evidence="11 15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12 15" id="KW-0520">NAD</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="15" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="15" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding" evidence="17">
        <location>
            <begin position="374"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00046881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU364066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAB0797458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAB0798503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="470" mass="51598" checksum="885835964199942C" modified="2020-02-26" version="1">MTNSVINHFNLRGRTLGKLGPLLHHPKIKHSTQPPSQTKSSYGKLKDEDRVFTNLYGRHDWRLQGALKRGDWYKTKDIMNKGPEWIINEIKISGLRGRGGAGFPSGVKWSFMLKPPDGRPKYLIINADEGEPGTCKDREIMRHDPHKLVEGCLLAGFAMGAKAAYIYIRGEFYNEASNMQVAIAEAYQAGLIGKNACESHYDFDIFMHRGAGAYICGEETALIESIEGKQGKPRLKPPFPADVGLFGCPTTVTNVETVAVAAAILRRGGSWFASFGRPNNSGTKLFAISGHVCTPCVVEEEMSIPLQELVERYGGGVVGGWENLLAIIPGGSSTPCIPQSVCNTAIMDFDGLIACGTSLGTAAVIVMNKQTDIIKAIARLIVFYKHESCGQCTPCREGTSWMDKIMARLVDGNARCEEIDMLYEISKQIEGHTICALGDAAAWPVQGLIRHFRPEIECRIQKNQAMKCCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AQM3</accession>
    <name>A0A5N4AQM3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA-directed DNA polymerase from mobile element jockey</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_07510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AQM3"/>
    <dbReference type="InParanoid" id="A0A5N4AQM3"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="254"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0799630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="313" mass="34929" checksum="0EB5A88CA482C145" modified="2020-02-26" version="1">MESIRMAHINARSLTSNFLQFHDYVQINNFDIIAVTETWLNDEINSNHVSIHNYQFIRKDRNTRGGGVGFYVKTQFKYSMIEMECSDYYEDLWIKISSKNKMDISEDERRAADNVVDTKTISLHQPIQVGTGRKIALASTYHKEGQILVPRIAASFISKEEKEKEEREREEYGQSKPHHYYGGYRPPHYSAGPRVGIPGLFGGHRPDPGEIYAHSGYGSTGLGYGHSGGGYLYPTPPTGLDSGGFMKKFGLKGLLLPLAGIAILGAAAALTANPVLLQLGTLHGRRRRRRSATKLASNSSVYPVNPRLRPDNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ARC0</accession>
    <name>A0A5N4ARC0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RZZ complex subunit KNTC1/ROD C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_07754</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ARC0"/>
    <dbReference type="InParanoid" id="A0A5N4ARC0"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005828">
        <property type="term" value="C:kinetochore microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990423">
        <property type="term" value="C:RZZ complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903394">
        <property type="term" value="P:protein localization to kinetochore involved in kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055403">
        <property type="entry name" value="ARM_KNTC1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052802">
        <property type="entry name" value="KNTC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055402">
        <property type="entry name" value="KNTC1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15688">
        <property type="entry name" value="KINETOCHORE-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15688:SF1">
        <property type="entry name" value="KINETOCHORE-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24520">
        <property type="entry name" value="ARM_KNTC1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24506">
        <property type="entry name" value="KNTC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KNTC1 N-terminal" evidence="1">
        <location>
            <begin position="31"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="KNTC1 first ARM-repeats" evidence="2">
        <location>
            <begin position="362"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0799874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1185" mass="136553" checksum="E9A29C2845D5D00C" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ARK4</accession>
    <name>A0A5N4ARK4_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_07819</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ARK4"/>
    <dbReference type="InParanoid" id="A0A5N4ARK4"/>
    <dbReference type="OrthoDB" id="20900at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34105">
        <property type="entry name" value="PROLINE-, GLUTAMIC ACID- AND LEUCINE-RICH PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34105:SF1">
        <property type="entry name" value="PROLINE-, GLUTAMIC ACID- AND LEUCINE-RICH PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0799939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="567" mass="65374" checksum="A5960E9B64589651" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ASS7</accession>
    <name>A0A5N4ASS7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Octanoyl-[acyl-carrier-protein]:protein N-octanoyltransferase LIPT2, mitochondrial</fullName>
            <ecNumber evidence="6">2.3.1.181</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PPYR_06162</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>octanoyl-[ACP] + L-lysyl-[protein] = N(6)-octanoyl-L-lysyl-[protein] + holo-[ACP] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9636"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:9928"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78463"/>
            <dbReference type="ChEBI" id="CHEBI:78809"/>
            <dbReference type="EC" id="2.3.1.181"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the LipB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.181" evidence="6"/>
    <dbReference type="EMBL" id="VVIM01000004">
        <property type="protein sequence ID" value="KAB0800422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ASS7"/>
    <dbReference type="FunCoup" id="A0A5N4ASS7">
        <property type="interactions" value="915"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4ASS7"/>
    <dbReference type="OrthoDB" id="19908at2759"/>
    <dbReference type="UniPathway" id="UPA00538">
        <property type="reaction ID" value="UER00592"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033819">
        <property type="term" value="F:lipoyl(octanoyl) transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16444">
        <property type="entry name" value="LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000035">
        <property type="entry name" value="Putative lipoyltransferase 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00013">
        <property type="entry name" value="LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000544">
        <property type="entry name" value="Octanoyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020605">
        <property type="entry name" value="Octanoyltransferase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00214">
        <property type="entry name" value="lipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010925">
        <property type="entry name" value="PRK14345.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10993:SF7">
        <property type="entry name" value="LIPOYLTRANSFERASE 2, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10993">
        <property type="entry name" value="OCTANOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21948">
        <property type="entry name" value="LplA-B_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016262">
        <property type="entry name" value="LPLase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01313">
        <property type="entry name" value="LIPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="10">
        <location>
            <begin position="33"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="7">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="77"/>
            <end position="84"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="143"/>
            <end position="145"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="156"/>
            <end position="158"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Cys" evidence="9">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR016262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR016262-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR016262-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR016262-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0800422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="227" mass="25750" checksum="7FBAF3C207668A62" modified="2020-02-26" version="1">MNKLVQIHKLGKISYVDSLKLQNKLVDLHRSNEATINALLLLEHPPVYTIGIRTKDYTAEDEKNLLATGAEFHRTNRGGLITFHGPGQLVVYPILNLKHFTPSMRWYVCHLEKTIINLCENLGLKAETSPHTGVWINDNKVCAIGVHGSQFITSHGLALNCCTNLEWYRHIVPCGIKDKWVTSLSKELNRHVSIDEIMPLFLNSFCKTFNCTYVDVDRSPIMTVEPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AU76</accession>
    <name>A0A5N4AU76_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA N(3)-methylcytidine methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_06552</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">S-adenosyl-L-methionine-dependent methyltransferase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the methyltransferase superfamily. METL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="VVIM01000004">
        <property type="protein sequence ID" value="KAB0800813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AU76"/>
    <dbReference type="FunCoup" id="A0A5N4AU76">
        <property type="interactions" value="255"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AU76"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026113">
        <property type="entry name" value="METTL2/6/8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22809">
        <property type="entry name" value="METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22809:SF5">
        <property type="entry name" value="TRNA N(3)-METHYLCYTIDINE METHYLTRANSFERASE METTL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037755">
        <property type="entry name" value="Mettl2_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR037755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0800813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="249" mass="28950" checksum="24F32DE04FD45A62" modified="2020-02-26" version="1">MEEQETNSPIVLTTDEINCLELQNKRLVTDYKAQMLEDRHWTTREFTDLLNLDCNLNSRRKVVLEIGCGVGNFIFPLLEEKINLFLFACDFSPRAIEFVKSNPLYNEDNVRAFVADVTTDDIFTTLEQSTVDIVTLVFVLSAIHPEKFLKVLQNIFLLLKPGGIILFRDYGLYDMAQLRFKAGNKISENFYMRQDGTRSYYFSLEFTSELLSKAGFEVVNISYIHRRTINKKDNIDVPRIFLQAKFKKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AUJ3</accession>
    <name>A0A5N4AUJ3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phenoloxidase-activating factor 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Prophenoloxidase-activating factor II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PPYR_05340</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000003">
        <property type="protein sequence ID" value="KAB0800986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AUJ3"/>
    <dbReference type="InParanoid" id="A0A5N4AUJ3"/>
    <dbReference type="OrthoDB" id="5918597at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000038">
        <property type="entry name" value="Serine protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050127">
        <property type="entry name" value="Serine_Proteases_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24264:SF54">
        <property type="entry name" value="PEPTIDASE S1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24264">
        <property type="entry name" value="TRYPSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024303247" description="Phenoloxidase-activating factor 2" evidence="10">
        <location>
            <begin position="22"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="11">
        <location>
            <begin position="133"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="127"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00068096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00076468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAB0800986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="380" mass="42349" checksum="26DF2105EEE82D70" modified="2020-02-26" version="1">MLLSVCVSLVQLALLNHEISSQHDPRFRPLTRSKRYLGLQKHYKINRRYQECIAPGDVPGHCKHAAFCEMNVLGYSKGSLDYLCVITEMHVGVCCPDDVLISKLTGSRIVMDLPAGVRDYDDDEELSTSGCGITSSSSRRTSEKQSRQWPWLAALYRPGDTQFSFCGGAVITDRHILTAAHCIHSASKDNIRVRLGEYNFMQVGETRARDFGVKDITEHKEYDPATYLHDIAIVTLDKPTVFDTYIWPICLPPMNGSYVNETVIIAGWGQESYSGPTSAILREVAVPVWEQEKCVESFTQRITENNLCAAAYEGGKDSCLGDSGCPLLYKLDNGRWATIGIVSWGIGCGNKDQPGIYTRVDKYIPWIVTHTIGEQIISLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AUS3</accession>
    <name>A0A5N4AUS3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Potassium voltage-gated channel subfamily KQT member 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PPYR_05367</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">1611_PpyrPB1</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>K(+)(in) = K(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29463"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000003">
        <property type="protein sequence ID" value="KAB0801013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AUS3"/>
    <dbReference type="FunCoup" id="A0A5N4AUS3">
        <property type="interactions" value="75"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AUS3"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000017">
        <property type="entry name" value="potassium voltage-gated channel subfamily KQT member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000016">
        <property type="entry name" value="Putative potassium voltage-gated channel subfamily KQT member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1910">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003937">
        <property type="entry name" value="K_chnl_volt-dep_KCNQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013821">
        <property type="entry name" value="K_chnl_volt-dep_KCNQ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47735">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47735:SF9">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 4-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03520">
        <property type="entry name" value="KCNQ_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00169">
        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01459">
        <property type="entry name" value="KCNQCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="200"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="325"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="16">
        <location>
            <begin position="129"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel voltage dependent KCNQ C-terminal" evidence="17">
        <location>
            <begin position="504"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="472"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="731"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="607"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="472"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="759"/>
            <end position="768"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF03520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAB0801013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="20">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="827" mass="93025" checksum="AFD18C4F98884518" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AVZ0</accession>
    <name>A0A5N4AVZ0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ras-specific guanine nucleotide-releasing factor 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_05841</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000003">
        <property type="protein sequence ID" value="KAB0801487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AVZ0"/>
    <dbReference type="OrthoDB" id="10254377at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00155">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019804">
        <property type="entry name" value="Ras_G-nucl-exch_fac_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF99">
        <property type="entry name" value="RASGEF DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00229">
        <property type="entry name" value="RasGEFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00720">
        <property type="entry name" value="RASGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="5">
        <location>
            <begin position="22"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="7">
        <location>
            <begin position="257"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="5">
        <location>
            <begin position="473"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="8">
        <location>
            <begin position="668"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="6">
        <location>
            <begin position="1169"/>
            <end position="1401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="742"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="899"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="984"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1038"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="150"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="423"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="742"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="755"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="796"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="807"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="899"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="928"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="989"/>
            <end position="1006"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0801487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1421" mass="161408" checksum="93732F7C7A2E5DF3" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-09-13" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AWM1</accession>
    <name>A0A5N4AWM1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tyr recombinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_03948</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0801762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AWM1"/>
    <dbReference type="InParanoid" id="A0A5N4AWM1"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0801762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="189" mass="22122" checksum="44DD40342443CF04" modified="2020-02-26" version="1">MEMDSDANFSCTPEEIVNAAGIATSNLLPEKSKDQYLKEYDLFMKWRTEKHVGSFSERALLCYFEEKSKQWKPPTLWPTYSKLKATLLINNVNIRKYSKLIAYLKNKSVGHKPKKSRTFSRDEIYKFLHNAPDELQFLMHKLALIFGIAGALRREELYKMTVEDMNDTGHVLIITKFRIQKHIFNVDLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AWT6</accession>
    <name>A0A5N4AWT6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">H15 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PPYR_03962</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the histone H1/H5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0801776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AWT6"/>
    <dbReference type="InParanoid" id="A0A5N4AWT6"/>
    <dbReference type="OrthoDB" id="6361449at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00073">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000140">
        <property type="entry name" value="Histone H1.0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005819">
        <property type="entry name" value="H1/H5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005818">
        <property type="entry name" value="Histone_H1/H5_H15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00538">
        <property type="entry name" value="Linker_histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00624">
        <property type="entry name" value="HISTONEH5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00526">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51504">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="H15" evidence="9">
        <location>
            <begin position="50"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="118"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="123"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="144"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="191"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="224"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0801776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="261" mass="26095" checksum="5FD924AD34F47840" modified="2020-02-26" version="1">MADTAVANQTSEASTGGGGASPPAAAKKALASSSQQQKKGTKGGARSKPSHPPTADMVNGAIKSLKERGGSSLQAIKKYLVTTYKIDAEKMAPFIKKYIKGAVASGALIQTKGKGASGSFKLAADAASPSSGGSAAKGKKKKVAAAAASTRRQKAASPAKKASPAASVKKQSSKSSPKKKKAPATASPQRKVAKAAAAKKRAGASASSAPETQAAASSPSKPKSPSKAKKTTKVPTKKPKAPKPKKAKQTKKPATGSPKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AXK3</accession>
    <name>A0A5N4AXK3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_04255</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AXK3"/>
    <dbReference type="InParanoid" id="A0A5N4AXK3"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33053">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33053:SF24">
        <property type="entry name" value="TRANSPOSASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0802069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="244" mass="27811" checksum="33B99A33EED2AC4F" modified="2020-02-26" version="1">MVCHYSKALLKPKSFSLFLKDFVDEAVDLCSNGLLFNNEHFTVEIIGFVCDAPAKSEVLGIKGHGGYSYCTKCSVRGITSTHKRVFLETDCPIRTHEDFINWADSSYRLNDTPLVQIPQLHFVNSIVLDYMHLVCLGVMRTMLNTWCNGDLPHKLSYNNISIVSEHLLVLSKSTPCEFARKPRDLKLIHRFKATEFRMFLLYFGPIVLKDILNSDKYNNFLTLHVAISISCSKCSPANTHIHYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AYR5</accession>
    <name>A0A5N4AYR5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aldehyde dehydrogenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_04660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AYR5"/>
    <dbReference type="InParanoid" id="A0A5N4AYR5"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006081">
        <property type="term" value="P:aldehyde metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012394">
        <property type="entry name" value="Aldehyde_DH_NAD(P)"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570:SF16">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE TYPE III, ISOFORM Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0802474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="204" mass="23202" checksum="FACD2C61539000AA" modified="2020-02-26" version="1">MSLSAEEVVTRARGAFNTGRTKPVEFREQQLKNLLRLYEENAPRLAEVLKADLAKHKQESIAMEIAFNTSNIRNTLAELRKWIGPERPPKYFMNMSDEVASPLVPQDSRITIGRIVTLVFQYTISCHNLLETDINFVSYTGQKIVPLGKIIVNVNFNGDTHALILNVIERGGPPLLGRDFLQNLIWGLVNVELQTVFIYLIFYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AZD3</accession>
    <name>A0A5N4AZD3_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_04897</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AZD3"/>
    <dbReference type="InParanoid" id="A0A5N4AZD3"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0802711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="177" mass="20506" checksum="7D64326472A09E2D" modified="2020-02-26" version="1">MEYEGVREITTTAAIGIIIVGIVHFGLLVFFFVSIIVLCVKVKKMRKILDSHTSLLQFRLHEGTQHPEDELAKRYAMPPRTQHSELSNNQYRYNPNFPSNQSHNLRRETETEYGKPLQLPRAQHPELKNSQYPSNSNFPPKQAHNLKGETDTEYGKHGPSMVMMHYPKPKRTNGHYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B076</accession>
    <name>A0A5N4B076_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Fibrillar collagen NC1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PPYR_05139</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PPC synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4B076"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005581">
        <property type="term" value="C:collagen trimer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005201">
        <property type="term" value="F:extracellular matrix structural constituent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.1000:FF:000007">
        <property type="entry name" value="Collagen type V alpha 3 chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10300">
        <property type="entry name" value="CoaB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035929">
        <property type="entry name" value="CoaB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050938">
        <property type="entry name" value="Collagen_Structural_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007085">
        <property type="entry name" value="DNA/pantothenate-metab_flavo_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000885">
        <property type="entry name" value="Fib_collagen_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001007">
        <property type="entry name" value="VWF_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37456:SF6">
        <property type="entry name" value="COLLAGEN ALPHA-1(XXIII) CHAIN-LIKE ISOFORM X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37456">
        <property type="entry name" value="SI:CH211-266K2.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01410">
        <property type="entry name" value="COLFI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04127">
        <property type="entry name" value="DFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00093">
        <property type="entry name" value="VWC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00038">
        <property type="entry name" value="COLFI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102645">
        <property type="entry name" value="CoaB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57603">
        <property type="entry name" value="FnI-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51461">
        <property type="entry name" value="NC1_FIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0176">Collagen</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0379">Hydroxylation</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024280010" description="Fibrillar collagen NC1 domain-containing protein" evidence="10">
        <location>
            <begin position="24"/>
            <end position="1747"/>
        </location>
    </feature>
    <feature type="domain" description="Fibrillar collagen NC1" evidence="11">
        <location>
            <begin position="1310"/>
            <end position="1533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="57"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="157"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="262"/>
            <end position="1270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="61"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="207"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="313"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="350"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="360"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="450"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="471"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="528"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="552"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="581"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="755"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="770"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="793"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="879"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="893"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="909"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="951"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1024"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1042"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1065"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1128"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="1199"/>
            <end position="1208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="1249"/>
            <end position="1264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAB0802953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1747" mass="174431" checksum="730F80E4BE20D134" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B0J4</accession>
    <name>A0A5N4B0J4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PPYR_00074</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4B0J4"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032071">
        <property type="entry name" value="DUF4806"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025476">
        <property type="entry name" value="Helitron_helicase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492:SF57">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16064">
        <property type="entry name" value="DUF4806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14214">
        <property type="entry name" value="Helitron_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helitron helicase-like" evidence="4">
        <location>
            <begin position="364"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="3">
        <location>
            <begin position="1007"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4806" evidence="5">
        <location>
            <begin position="1447"/>
            <end position="1526"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="34"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0803104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1534" mass="175851" checksum="37CDB346CF568D43" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-09-13" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B179</accession>
    <name>A0A5N4B179_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_00286</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B179"/>
    <dbReference type="InParanoid" id="A0A5N4B179"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024387092" description="Peptidase S1 domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0803316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="283" mass="31609" checksum="E235868A84FF4EB1" modified="2020-02-26" version="1">MLSVAVPFLVAISTVYIVVSNKNDTTQLACEEHCHQIRHRQRGAVVLPNSALSRSTPTFKKEDAIEFIASITQKASSSDVFTFLCTGTVINLHWVLGSITCDQTERLPGGNIDDFSYYARAGSLNWLGGDLRKVHSTTSVGLLILYKLAIPFEKDRVVPVHFPGGKSYFGEVSSMEMYRWRIEKDYSAENIQNAELDLEHVKETVVPECDVTPNVHCFVSEENLPCGDFKGGIVMKSMVIMGVVLQQYCKDDGNYVTVYDFSKDVPTFIEMGIELMREAEGKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-06-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B1D4</accession>
    <name>A0A5N4B1D4_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_00364</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B1D4"/>
    <dbReference type="InParanoid" id="A0A5N4B1D4"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0803394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="103" mass="12025" checksum="855CBFB939F3E33D" modified="2020-02-26" version="1">MYINFHMYPVRRAFQSSPNIPEDAWNPLVQYSISDKSISIRSNNHQAGYVYIHHKHPDNFAVQRIVSDDHDFAFITFVMLNRQGTPISRHTKPPEFPVTLDVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B1P6</accession>
    <name>A0A5N4B1P6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_00456</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B1P6"/>
    <dbReference type="InParanoid" id="A0A5N4B1P6"/>
    <dbReference type="OrthoDB" id="10011262at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd14978">
        <property type="entry name" value="7tmA_FMRFamide_R-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019430">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052954">
        <property type="entry name" value="GPCR-Ligand_Int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641:SF25">
        <property type="entry name" value="CNMAMIDE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641">
        <property type="entry name" value="FMRFAMIDE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10328">
        <property type="entry name" value="7TM_GPCR_Srx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="34"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="195"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="50"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0803486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="388" mass="43687" checksum="D97208F8898EFB55" modified="2020-02-26" version="1">MYPVQLREMERTSRNIRYIDNGNVLSVLPAFSNFVYSALIPTICAFGIIGNLICLVVLSKMQKRCSFYVYLSVVATANFLTCIVLFVSGLSRGLLSNHGNWETLDSLIFLPIGECLNCISACATVFVTIDRLIYLKKPTQTFKPKFCKRGVAGRIMLFIACGSAVYVLPYCFVYKLGENWTVEKTPFYDSIYFTIYNWLDVCLLAVVPAIVLSIGNTMLFLSIRNACQILKDCQSKVCNGKIRVIVDQTKITITLVAIVFVHLIGEVPAHFTRRITSANILFGGDDKQAEDSVIMEYFRVATTLLNALHLAMKFILYANFCPPFCKALKNCVCLKKHRKFNRTTVKLYLIEINFLATLEKCAKECSQIKIFDSLVGKSSALRVQNILC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B219</accession>
    <name>A0A5N4B219_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Metalloendopeptidase</fullName>
            <ecNumber evidence="2">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_00538</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1 2">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="2"/>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B219"/>
    <dbReference type="InParanoid" id="A0A5N4B219"/>
    <dbReference type="OrthoDB" id="291007at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04280">
        <property type="entry name" value="ZnMc_astacin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034035">
        <property type="entry name" value="Astacin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF873">
        <property type="entry name" value="METALLOENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 2" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 2" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1 2" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024469145" description="Metalloendopeptidase" evidence="2">
        <location>
            <begin position="20"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12A" evidence="3">
        <location>
            <begin position="45"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="87"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0803568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="244" mass="27200" checksum="213FA930546F1453" modified="2020-02-26" version="1">MYFKTVLVSSVLLFAGVASGIICAGDPQEDSGKSEDDMFFLRKRNGVINPRYRWRNGQICYTISPAFNQTQVELIKSTVATGFTGTCIKWVECQSCCNGDYVYITNDHKGCSSSSTGRAGVGRQLLNLAKECLYKGTMLHEMLHVVGFKHQHSSPERDDYVTIKIENVMDGFEIQFGKYTPDYLSSFGQPYDYCSIMHYHETAFSKNGKPTIVPKLPTTCKLGAASELSPIDKLKVNAMYKCGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B319</accession>
    <name>A0A5N4B319_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Peptidase M13 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PPYR_00913</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B319"/>
    <dbReference type="InParanoid" id="A0A5N4B319"/>
    <dbReference type="OrthoDB" id="6775918at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08662">
        <property type="entry name" value="M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF167">
        <property type="entry name" value="FI17812P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="11">
        <location>
            <begin position="80"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="10">
        <location>
            <begin position="512"/>
            <end position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAB0803943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="694" mass="81466" checksum="059D540F0C9BA21B" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B3H0</accession>
    <name>A0A5N4B3H0_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_01129</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B3H0"/>
    <dbReference type="InParanoid" id="A0A5N4B3H0"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46409:SF1">
        <property type="entry name" value="HTH PSQ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0804159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="156" mass="18413" checksum="A2BF4D3548C256AD" modified="2020-02-26" version="1" fragment="single">LSHSRWLTTANRVLRLYIATYNPTFELKTIATFVVKVYAPMWFLIKRYPSCKDGSRHLCQLIQLSRYLSDELKEIIDPVIQRNAYASHPENVLLSMITDNRPHIRELGLRRVLKARKEARVGVREYIIPPLNFQANDYVEMIYWQNVKVTEPPVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B3U0</accession>
    <name>A0A5N4B3U0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4806 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_01232</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B3U0"/>
    <dbReference type="InParanoid" id="A0A5N4B3U0"/>
    <dbReference type="OrthoDB" id="6782345at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032071">
        <property type="entry name" value="DUF4806"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34153:SF2">
        <property type="entry name" value="SI:CH211-262H13.3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34153">
        <property type="entry name" value="SI:CH211-262H13.3-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16064">
        <property type="entry name" value="DUF4806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4806" evidence="2">
        <location>
            <begin position="258"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0804262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="368" mass="42650" checksum="DC860D2E4B790BAE" modified="2020-02-26" version="1">MSKSCAQWKKDTSSKQYAVVRFDDESVSEVPITWLFDNNRSSWWPRNSKVATSYINRYSPPDPDSWSKYSVVAVEAICDSLEVARKKAEDIHYSEGEDKDRGRGKRLVQRSTLLSNFIDGSNNGSSDSDVEARTKRILTPPPELPPDLDISSMEMVILNKNTNIDTMNEQFPHGEYAEDEYVEEYAESYAESQEVPVNQFNSQSINRNGNYEISVMHKILEMVTEIKIQVNDIARNMQSFKVDKQPVEQYDIFTKCLPLNSFEAIEKFEELISDLEINKLFKTFLTTIGGNDYKDNINRVYKILFTNELGMGCSWLGQRNNKRMVDLKIIAAVKEIIIGQHNIQQKLIENCSSEWFRHARQRYQREKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B499</accession>
    <name>A0A5N4B499_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nuclease HARBI1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_01344</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B499"/>
    <dbReference type="InParanoid" id="A0A5N4B499"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0804374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="234" mass="27437" checksum="72EC7D66C102A823" modified="2020-02-26" version="1">MNYTDFDEPITDDEDFLELMQLFLDDEEEPLVSKNIRKRPDYFNILSEKEFVERFRLTKEGALEVLEKISDHIARKTERNHAVTPITMLLVTLRFYATGSMLIVVGDFCGIDKSTASRIVAQRCFGIWKRRFPVLAFGMRVRLDRIQPIIVATAVLHNIARMRNIPDPEYNPDVEEAVHYLENVNNNNYAVGDEARIGPNNPKVFCYYHIHENTHALFLNSVNFWEIYYHKHKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B4J1</accession>
    <name>A0A5N4B4J1_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_01509</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B4J1"/>
    <dbReference type="InParanoid" id="A0A5N4B4J1"/>
    <dbReference type="OrthoDB" id="6773791at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024287201" evidence="1">
        <location>
            <begin position="21"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0804539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="390" mass="43712" checksum="2EF02FDD269BBFF0" modified="2020-02-26" version="1">MDYKIILTITTCVALHSVQCMEIPSNCSKSDNRCLQKREEMHWCTDQGCSTCTDHNCLMTCKGFNCGICPKGDCCNGTNCNVCYNNSCCATESCNYCIRTCNLACTNYTLCEKVCISKCHKSDKTVFVVPSALHGNHVTVYIRGTPYKGDLTSRPFSSQDKTAIVLIDGVDHIAMVLSLPQRTCKETKCDSTCKGEHCNGECMKDCLSKCSKDCNRFCLAQCSKSSPNKAFNYYDTLTPGCCHVVHPLICHNSPFFGQSYCSRKSHRECSAICTSKFIHIGPRHGQLRQHIHCYYIQAYPYIYCGNYVIQNCDSCYVCNGSYNPSECVKSVLCSNICRENFLPFKPTAPKKEAAPPPMSVPRYIPNPYLHPFGYSYYNPNQLFSGPQQYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B4K1</accession>
    <name>A0A5N4B4K1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PPYR_01466</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B4K1"/>
    <dbReference type="InParanoid" id="A0A5N4B4K1"/>
    <dbReference type="OrthoDB" id="6750460at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF74">
        <property type="entry name" value="POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
        <property type="entry name" value="HTH_psq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="5">
        <location>
            <begin position="58"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="408"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="527"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="419"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="527"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="547"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0804496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="639" mass="70867" checksum="15F60C1CDF584EA3" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B5W5</accession>
    <name>A0A5N4B5W5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 20">Phosphatidate cytidylyltransferase, mitochondrial</fullName>
            <ecNumber evidence="6 20">2.7.7.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18 20">CDP-diacylglycerol synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19 20">Mitochondrial translocator assembly and maintenance protein 41 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">PPYR_01914</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">1611_PpyrPB1</strain>
            <tissue evidence="21">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="20">Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+) = a CDP-1,2-diacyl-sn-glycerol + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:16229"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.7.7.41"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 20">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 20">Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 20">Mitochondrion inner membrane</location>
            <topology evidence="2 20">Peripheral membrane protein</topology>
            <orientation evidence="2 20">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 20">Belongs to the TAM41 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.41" evidence="6 20"/>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B5W5"/>
    <dbReference type="FunCoup" id="A0A5N4B5W5">
        <property type="interactions" value="1388"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4B5W5"/>
    <dbReference type="OrthoDB" id="341477at2759"/>
    <dbReference type="UniPathway" id="UPA00557">
        <property type="reaction ID" value="UER00614"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004605">
        <property type="term" value="F:phosphatidate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016024">
        <property type="term" value="P:CDP-diacylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015222">
        <property type="entry name" value="Tam41"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13619">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13619:SF0">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09139">
        <property type="entry name" value="Tam41_Mmp37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028840">
        <property type="entry name" value="Mmp37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 20" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="13 20" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 20" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="14 20" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11 20" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10 20" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="16 20" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="17 20" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 20" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00018337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00029893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00031502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRNR" id="PIRNR028840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAB0804944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="338" mass="38699" checksum="A7E676BC14C8ADA7" modified="2020-02-26" version="1">MATIKSLVVPPLYSKILSNFPSNFSFCFAYGSGVKKQTDNVGPTPNSNVIDLVFCVDNAYEWHERNLQLNKWHYSGLKYLGHHNITKFQRGYGAKVYFNTLIPLEEVTIKYGVVSRQDLITDLLEWSDLYLAGRLHKPVEIVIHPTSSELQTAIQLNLQSAVHASLLILPETFTEYQFYHTVANLSYAGDFRMIFGENKQKVDNIVRPQLLKFRDLYKPFLKNLHDYVDFPVDTVSETETVKCLQDVGPLSRLHHLNQLPRWPQKALTKFWNRGTVRQDTEDVLRAIAYDPDCNLIVNKCVNGIVWQSSISQSLKSALTAGVVKSLRYSAKKITKMLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B5X4</accession>
    <name>A0A5N4B5X4_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_01987</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0805017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B5X4"/>
    <dbReference type="InParanoid" id="A0A5N4B5X4"/>
    <dbReference type="OrthoDB" id="382863at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053347">
        <property type="entry name" value="Axonemal_MT_stabilizer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37404">
        <property type="entry name" value="HCG1796489"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37404:SF1">
        <property type="entry name" value="HCG1796489"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0805017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="341" mass="38708" checksum="58B46649199102B0" modified="2020-02-26" version="1">MPEPLICTSNTLGNIDYGIPIVANKASDFRTSTGLYHRLIPNVAQEFDCRVKARIKPELNKSNVVVRDESSKSTYTNAHHWKFPDKSVVRHFPVPMNSSDISYIRGAQEKCFRKPPPVKPTKISEMKESFYPSYVKSCSEEVRPPEPYAKCEIRGLGRDEQPAIRPEEKGSWKLMDPYLTTSRSTYLPFTVNQQNGVAKKDIVTYYDASNFPKVKGFGPRNGPAIDPLEPKRKVPMLDRMPFKKQPFERRLYVLSKTVPNFGKKSEMKANFVGQSFSDMSPYLHQCGVEFPCSLSNASAWQNLAPPGMYCTEYCHIGSGWPVNSIVDYGLPPEYVKHKQCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B5Y8</accession>
    <name>A0A5N4B5Y8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Fork-head domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_01740</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B5Y8"/>
    <dbReference type="InParanoid" id="A0A5N4B5Y8"/>
    <dbReference type="OrthoDB" id="5402974at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20048">
        <property type="entry name" value="FH_FOXD4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000016">
        <property type="entry name" value="Forkhead box protein I1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050211">
        <property type="entry name" value="FOX_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018122">
        <property type="entry name" value="TF_fork_head_CS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829:SF402">
        <property type="entry name" value="FORK HEAD DOMAIN-CONTAINING PROTEIN FD3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829">
        <property type="entry name" value="FORKHEAD BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00657">
        <property type="entry name" value="FORK_HEAD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Fork-head" evidence="8">
        <location>
            <begin position="68"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="6">
        <location>
            <begin position="68"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="28"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="46"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0804770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="333" mass="37760" checksum="027E43AEE4EA2092" modified="2020-02-26" version="1">MLIMDDGCRLFDPRDLHQTEMLLERYPTSESPLDLRGQQGNQIEGNKQKDDIYGKEKASPKKSSSLIKPPYSYIALITMAILQSPHKKLTLSGICEFIMTRFHYYREKFPAWQNSIRHNLSLNDCFIKIPREPGNPGKGNYWTLDPLAEDMFDNGSFLRRRKRYKRPSPTNLLLRDHHSSAMVASFLNQENYQHGLFSHPSLHNPYSYIPSLPTSLPSGLPFLPPLDLARLGLGHLNILPQPSICKPVPVQPPSVTPVSDVDDITSTEIYKKAKSGFSIESLIGSEEDKQKPLHIVNIRSESPEPINMSPKFVPIHNQVSAFSPLSSSDDWTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1JU13</accession>
    <name>A0A1Y1JU13_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GTP-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PPYR_12095</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
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        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
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        <text evidence="7">Promotes degradation of target mRNA species. Plays a role in the regulation of circadian mRNA stability. Binds GTP and has GTPase activity.</text>
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        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
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        <location>
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        <source>
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        <source>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00025630"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="PROSITE" id="PS51722"/>
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        <source>
            <dbReference type="EMBL" id="JAV51618.1"/>
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        <source>
            <dbReference type="EMBL" id="KAB0795256.1"/>
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        <source>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
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                <person name="Al-Wathiqui N."/>
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            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
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            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
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        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
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        <property type="protein sequence ID" value="JAV59236.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
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        <property type="protein sequence ID" value="KAB0799039.1"/>
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        <property type="project" value="TreeGrafter"/>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
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                <person name="Lewis S.M."/>
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            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
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        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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        <property type="protein sequence ID" value="JAV60886.1"/>
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        <location>
            <begin position="12"/>
            <end position="36"/>
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        <location>
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        </location>
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        <location>
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        </location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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    </feature>
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    </feature>
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        </location>
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        <location>
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        <location>
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        <location>
            <begin position="17"/>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="JAV60886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0804707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="466" mass="52267" checksum="48C337F1C282B0A2" modified="2017-08-30" version="1">MMRDTARGCKVYIEIPVLLLSFAVMFENTISTHLVLYKTCYVTLGFNATDCAMLGTGHESNETALLETMVQPYAAILLMGQSFIHAFIQPVFCFFLSSWSDKYGRKPILLSSFIGYIGSYMVMIVISAIPESSPWLILLSLIPICFTGGFPLVITTSVSYITDITEEKDRGLRLGSWEAAFTIGILLGNSCSSFALRAFGYLGIYVICIGCSILALFYIMFLLDESVVNVETEDKFKIFKLSLVKKTMNNTFDGRNVHDKLMIVSVMALMLLYTVARFSDHGILFLYLRQSFGWSLQRFTLFASFKSTVAVVGSIIGAFLLNKVLRVKETVVLIIAFLTTTCYYTLLGLATANWQIYMSGCFKCLVGAINPMARLLLSKLIERKDIGKVLGLIVALESIIGHIGNSLFTYLYNLTLSTYPQTFCFVTAGIYLFEVILTIAILYMQNRHRRRGYVSMESEESTREES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1KR48</accession>
    <name>A0A1Y1KR48_PHOPY</name>
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        <recommendedName>
            <fullName evidence="11">Dynein axonemal light chain 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PPYR_00648</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the dynein light chain LC1-type family.</text>
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        <property type="protein sequence ID" value="JAV63784.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:alpha-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:outer dynein arm assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454:SF73">
        <property type="entry name" value="DYNEIN AXONEMAL LIGHT CHAIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
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        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="4"/>
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    </dbReference>
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        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0243">Dynein</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7" id="KW-0505">Motor protein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00049659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="JAV63784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAB0803678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="190" mass="21675" checksum="F6D5A2C4465A0CB0" modified="2017-08-30" version="1">MARATTIKEAMKKWEEKHPNEEISKATEVGLQFQWPPIEKMDNSLASLTSVRRLSLSTNVIEKISGLNSLKNLRILSLGRNYIKSFAGLEALGETLEELWISYNLIEKVKGVGALKKLKVLYMSNNLVKEWGQFNLLQEIPSLENLLFIGNPLFDSLDETVWRTEASKRLPNLKKLDGETVLREEAEEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1KVI4</accession>
    <name>A0A1Y1KVI4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">MoaB/Mog domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PPYR_07336</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">1611_PpyrPB1</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">1611_PpyrPB1</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>adenylyl-molybdopterin + molybdate = Mo-molybdopterin + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:35047"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
            <dbReference type="ChEBI" id="CHEBI:62727"/>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>molybdopterin + ATP + H(+) = adenylyl-molybdopterin + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:31331"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58698"/>
            <dbReference type="ChEBI" id="CHEBI:62727"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the MoeA family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the MoeA family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the MoaB/Mog family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01078176">
        <property type="protein sequence ID" value="JAV62885.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01078175">
        <property type="protein sequence ID" value="JAV62887.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1KVI4"/>
    <dbReference type="FunCoup" id="A0A1Y1KVI4">
        <property type="interactions" value="762"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1KVI4"/>
    <dbReference type="OrthoDB" id="4349954at2759"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099634">
        <property type="term" value="C:postsynaptic specialization membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061598">
        <property type="term" value="F:molybdopterin adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061599">
        <property type="term" value="F:molybdopterin molybdotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007529">
        <property type="term" value="P:establishment of synaptic specificity at neuromuscular junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097112">
        <property type="term" value="P:gamma-aminobutyric acid receptor clustering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072579">
        <property type="term" value="P:glycine receptor clustering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098970">
        <property type="term" value="P:postsynaptic neurotransmitter receptor diffusion trapping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00887">
        <property type="entry name" value="MoeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00886">
        <property type="entry name" value="MogA_MoaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.190.11:FF:000001">
        <property type="entry name" value="Molybdopterin molybdenumtransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.980.10:FF:000001">
        <property type="entry name" value="Molybdopterin molybdenumtransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.980.10:FF:000002">
        <property type="entry name" value="Molybdopterin molybdenumtransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="entry name" value="MoaB/Mog-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.340.10">
        <property type="entry name" value="MoeA, C-terminal, domain IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.10">
        <property type="entry name" value="Molybdopterin biosynthesis moea protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.190.11">
        <property type="entry name" value="Molybdopterin biosynthesis moea protein, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008284">
        <property type="entry name" value="MoCF_biosynth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038987">
        <property type="entry name" value="MoeA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005111">
        <property type="entry name" value="MoeA_C_domain_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036688">
        <property type="entry name" value="MoeA_C_domain_IV_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005110">
        <property type="entry name" value="MoeA_linker/N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036135">
        <property type="entry name" value="MoeA_linker/N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00177">
        <property type="entry name" value="molyb_syn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10192:SF5">
        <property type="entry name" value="GEPHYRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10192">
        <property type="entry name" value="MOLYBDOPTERIN BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03454">
        <property type="entry name" value="MoeA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03453">
        <property type="entry name" value="MoeA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63867">
        <property type="entry name" value="MoeA C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63882">
        <property type="entry name" value="MoeA N-terminal region -like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="Molybdenum cofactor biosynthesis proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01078">
        <property type="entry name" value="MOCF_BIOSYNTHESIS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01079">
        <property type="entry name" value="MOCF_BIOSYNTHESIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 13" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="11 13" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="12" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MoaB/Mog" evidence="14">
        <location>
            <begin position="7"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="MoaB/Mog" evidence="14">
        <location>
            <begin position="377"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="JAV62887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAB0799456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="607" mass="65807" checksum="69A90768319F20A4" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1KZ86</accession>
    <name>A0A1Y1KZ86_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Ras-related protein Rab-39B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PPYR_04099</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Cytoplasmic vesicle membrane</location>
            <topology evidence="12">Lipid-anchor</topology>
            <orientation evidence="12">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01068891">
        <property type="protein sequence ID" value="JAV66713.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0801913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1KZ86"/>
    <dbReference type="FunCoup" id="A0A1Y1KZ86">
        <property type="interactions" value="288"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1KZ86"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032482">
        <property type="term" value="P:Rab protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04111">
        <property type="entry name" value="Rab39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000358">
        <property type="entry name" value="RAB39B, member RAS oncogene family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041818">
        <property type="entry name" value="Rab39"/>
    </dbReference>
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        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0072">Autophagy</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0636">Prenylation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="JAV66713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAB0801913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="218" mass="24647" checksum="FA2897CF0CD69245" modified="2017-08-30" version="1">MVEPIFDYQFRLILIGDSTVGKSSLLKYFTDGKFAELSDPTVGVDFFARLIEVKDGTRVKLQLWDTAGQERFRSITKSYYRNSVGALLVYDICNRASFEHIPLWMAEAKRHIEPHRPIFALVGCKLDLVSNGGHREVSKEEAKAFADQNGLHHIETSARKGTNVEEAFRSVTQEVYNRIQSGEYKVEDGWDGIKTGFTRPNGMDFNLIEAEPAKSSCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1L0Z2</accession>
    <name>A0A1Y1L0Z2_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NOT2/NOT3/NOT5 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_09743</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CNOT2/3/5 family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01067874">
        <property type="protein sequence ID" value="JAV67342.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0795682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1L0Z2"/>
    <dbReference type="FunCoup" id="A0A1Y1L0Z2">
        <property type="interactions" value="1872"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1L0Z2"/>
    <dbReference type="OrthoDB" id="25391at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000036">
        <property type="term" value="P:regulation of stem cell population maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.1020:FF:000005">
        <property type="entry name" value="Regena, isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1020">
        <property type="entry name" value="CCR4-NOT complex subunit 2/3/5, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038635">
        <property type="entry name" value="CCR4-NOT_su2/3/5_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040168">
        <property type="entry name" value="Not2/3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007282">
        <property type="entry name" value="NOT2/3/5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23326">
        <property type="entry name" value="CCR4 NOT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04153">
        <property type="entry name" value="NOT2_3_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NOT2/NOT3/NOT5 C-terminal" evidence="5">
        <location>
            <begin position="241"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="26"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="71"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="88"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="117"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="154"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="JAV67342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0795682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="379" mass="41479" checksum="0656345169D3D590" modified="2017-08-30" version="1">MANLNFTRNIGGSSLARSNVGFGGSSMSGHVTPVFGQRAPSDRRGMPGLGGSNQIGSMSALGGYNSLQSVFGSGDTNTPPLLDLSEFPSLTNRNATDNVPQPNPMPGAKPYVGMVKQPTTESNEFTMSSEDFPALPGTHHREGPSPGGGHQSDKNSSSSASDSGTDTRTSEKSSTKQGIQTYPDGRVTNIPASMVNDQFGIVGLLTFIRAAETDPNLVSLALGQDLTALGLNLNSPDNLYPTFGGPWAEQPCRPQDIDFHVPPEYLVNSAIRDKLAGVKFTRYKDDLLFFMFYNNCGDVFQVLAAVELYNREWRYHTEEKVWITQVPGMVLLEKTSTYERGTYYFFDVHNWRKVAKEFHLDYSKLEGRPVIQQSMHNAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1L870</accession>
    <name>A0A1Y1L870_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Arrestin C-terminal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_03139</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arrestin family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01067990">
        <property type="protein sequence ID" value="JAV67277.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1L870"/>
    <dbReference type="InParanoid" id="A0A1Y1L870"/>
    <dbReference type="OrthoDB" id="2333384at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF17">
        <property type="entry name" value="FI21816P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0716">Sensory transduction</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="3">
        <location>
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        <location>
            <begin position="169"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="JAV67277.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAB0791339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="309" mass="35355" checksum="44B3768288369684" modified="2017-08-30" version="1">MTEKCVINVDKRELFPGETLSGTVELSFKTGKRVKDITVTLHGEGVLRIAHENRGDPIIEEYIHEEVEILKLKKYNSEEREIVLIKSGDHFFEYFIKLPNNLPSTFSLKRLNISYRVTVEVDVQGFMEPLEDSKSITICSYIDLNTVLMPIRRPLRATSVNDSCCICFKMQPLSLKIELPQGGYVPSEIVNVACFVRNKSMMNVSKVSFKIIQVFELVGRSKTYRKERLLQKIYVPDSQVPKGMQKLFRAQLQIPEQTKAPSLTSCHMLRMHCELVGKAVLPYPHFDLIASIPFYLGTVPLQFTPIPEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="9">LRRCT domain-containing protein</fullName>
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        <name evidence="7" type="ORF">PPYR_05910</name>
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    <organism evidence="6">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Hexapoda</taxon>
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            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
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    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
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                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
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        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
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    </dbReference>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="JAV71456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0801556.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
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    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="675" mass="76794" checksum="5D07889901CCCB9F" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="2">Winged helix Storkhead-box1 domain-containing protein</fullName>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
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            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
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                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
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            <dbReference type="PubMed" id="30324905"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="4">1611_PpyrPB1</strain>
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        </source>
    </reference>
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        <property type="protein sequence ID" value="JAV75095.1"/>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LTN6</accession>
    <name>A0A1Y1LTN6_PHOPY</name>
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        <recommendedName>
            <fullName evidence="4">Spt20-like SEP domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="6" type="ORF">PPYR_06752</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SPT20 family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01050959">
        <property type="protein sequence ID" value="JAV75262.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01050957">
        <property type="protein sequence ID" value="JAV75264.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01050956">
        <property type="protein sequence ID" value="JAV75265.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01050951">
        <property type="protein sequence ID" value="JAV75272.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0798872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1LTN6"/>
    <dbReference type="FunCoup" id="A0A1Y1LTN6">
        <property type="interactions" value="325"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1LTN6"/>
    <dbReference type="OrthoDB" id="1932706at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021950">
        <property type="entry name" value="Spt20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046468">
        <property type="entry name" value="Spt20-like_SEP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13526">
        <property type="entry name" value="TRANSCRIPTION FACTOR SPT20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13526:SF8">
        <property type="entry name" value="TRANSCRIPTION FACTOR SPT20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12090">
        <property type="entry name" value="Spt20_SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spt20-like SEP" evidence="4">
        <location>
            <begin position="86"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="557"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="JAV75265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0798872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1022" mass="112568" checksum="2809775B474DD722" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LVQ4</accession>
    <name>A0A1Y1LVQ4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Platelet-derived growth factor (PDGF) family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_10632</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01048811">
        <property type="protein sequence ID" value="JAV76385.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01048810">
        <property type="protein sequence ID" value="JAV76387.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01048809">
        <property type="protein sequence ID" value="JAV76390.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01048807">
        <property type="protein sequence ID" value="JAV76392.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1LVQ4"/>
    <dbReference type="InParanoid" id="A0A1Y1LVQ4"/>
    <dbReference type="OrthoDB" id="6677701at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035099">
        <property type="term" value="P:hemocyte migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000072">
        <property type="entry name" value="PDGF/VEGF_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21719">
        <property type="entry name" value="FI06402P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21719:SF1">
        <property type="entry name" value="FI06402P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00341">
        <property type="entry name" value="PDGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50278">
        <property type="entry name" value="PDGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011907411" description="Platelet-derived growth factor (PDGF) family profile domain-containing protein" evidence="1">
        <location>
            <begin position="30"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Platelet-derived growth factor (PDGF) family profile" evidence="2">
        <location>
            <begin position="39"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="JAV76390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0796571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="146" mass="16753" checksum="FB68BD64C842DAC1" modified="2017-08-30" version="1">MAIKCLPTLVFKSILVCGLVLLIISTCESQLSRQENVKRFQRHMEVLKRFPCDLPQPRSISVDELLSDRLETFESAQPHTTVLHRCDSGTGCCSQKSHVCTVAHSEQVELHFYVTDTVRQRNSEFREFLVTNHTRCSCQSKKNDIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1M5A1</accession>
    <name>A0A1Y1M5A1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nuclear respiratory factor 1 NLS/DNA-binding dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PPYR_05448</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NRF1/Ewg family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01041668">
        <property type="protein sequence ID" value="JAV80238.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01041665">
        <property type="protein sequence ID" value="JAV80241.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000003">
        <property type="protein sequence ID" value="KAB0801094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1M5A1"/>
    <dbReference type="FunCoup" id="A0A1Y1M5A1">
        <property type="interactions" value="383"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1M5A1"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="NRF1/Ewg"/>
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        <property type="entry name" value="Nrf1_NLS/DNA-bd_dimer"/>
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        <property type="entry name" value="NUCLEAR RESPIRATORY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="JAV80238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0801094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="521" mass="55690" checksum="C5493F6DDB43443D" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1M9M8</accession>
    <name>A0A1Y1M9M8_PHOPY</name>
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        <recommendedName>
            <fullName evidence="7">Eukaryotic translation initiation factor 3 subunit I</fullName>
            <shortName evidence="7">eIF3i</shortName>
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        <name evidence="10" type="ORF">PPYR_10981</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
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            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
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    <comment type="subunit">
        <text evidence="7">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
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        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat STRAP family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the eIF-3 subunit I family.</text>
    </comment>
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        <property type="molecule type" value="Transcribed_RNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:RNA binding"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="project" value="UniProtKB-UniRule"/>
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    </dbReference>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR19877">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT I"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT I"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EIF3I"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
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        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="6"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
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        </location>
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        <location>
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        </location>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00038394"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="JAV81698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0796920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="326" mass="36303" checksum="1EDFE1AFFCDAB3ED" modified="2017-08-30" version="1">MKPLILHGHERAITQIKYNREGDLLFSSSKDTIPNVWYSLNGERLGTFNGHQGAVWCIDIDWTTTRFLSGAGDNSLKLWDVETGTTIGTISTNSPVRACNFSYSANMAVFATDKSMGHQCEIHIIDVRNADESLGKSSPILRIPINGPRVSSLIWGALDETLLTGHEDGEIMQWDLQTGKKISNIKEHDKVIMDMQMSKDATMFITASKDHTAKLFDSDNLMLLKTYKTERPVNSAAVSPILEHVVLGGGQDAMDVTTTSARIGKFDSRFFHLAFEEEFGRVKGHFGPINSVAFHPDGKSYSSGGEDGYVRVHNFDQSYFEYGFDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1M9Z8</accession>
    <name>A0A1Y1M9Z8_PHOPY</name>
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        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
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        </recommendedName>
    </protein>
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        <name evidence="20" type="ORF">PPYR_11307</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
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                <person name="Al-Wathiqui N."/>
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            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="20 21" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">1611_PpyrPB1</strain>
            <tissue evidence="20">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">1611_PpyrPB1</strain>
            <tissue evidence="20">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family. DDX41 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="GEZM01041772">
        <property type="protein sequence ID" value="JAV80167.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01041767">
        <property type="protein sequence ID" value="JAV80177.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01041764">
        <property type="protein sequence ID" value="JAV80186.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01041762">
        <property type="protein sequence ID" value="JAV80190.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0794468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1M9Z8"/>
    <dbReference type="FunCoup" id="A0A1Y1M9Z8">
        <property type="interactions" value="2292"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
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            <begin position="65"/>
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        <source>
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        <source>
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        <source>
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        <source>
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        </source>
    </evidence>
    <sequence length="619" mass="69749" checksum="C7E1B4CB2A2DF80E" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1MJN7</accession>
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        <recommendedName>
            <fullName evidence="7">Zinc finger RNA-binding protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="11" type="ORF">PPYR_04651</name>
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    <organism evidence="10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
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        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="KAB0802465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="interleukin enhancer-binding factor 3 isoform X1"/>
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    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
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        <location>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
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                <person name="Bessho-Uehara M."/>
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                <person name="Shigenobu S."/>
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    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="2">
        <location>
            <begin position="44"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="JAV86041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0798800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="497" mass="56269" checksum="355C98E554EAC386" modified="2017-08-30" version="1">MAATLKKANGLCLIFYYCLSLCIINLGSIAAQNADSNVKKKDEEFTCPEGLGNGNYADPQTCRRFYQCVDGYPYLNRCPSGLRFDDISKFCTFPNEARCGPIIPTPAPSTEPPIDLAVKCNPEECLLPECFCSKDGTNIPGDFTPSEIPQMILLTFDGAVNLNNYHYYKKLFKKYTNPNGCPIKGTFYVAHEYSNYQMIQELASSSHEIGTETISLQTGLQDKGYEEWVGEMIGMREILKHFANISKNEVVGMRAPFLKPGRNTQYMVLEDFGYLYDSSVGVPVSPIPVWPYTLDYKIPHECKSGTCPTKSFPGIWEIPLNSHYVETFEGGHCPYLDQCVLHNHDANEVFEWLQEDFSRHYDQNKAPYMMPFHTNWFSIKALEDGLHKFVNWTQTLPDVWFVTATQALTWITDPKPLTELNKFEAWDCKKKNGNIPKTPCLSPNKCALSFKPDNQNFTDTRYLETCVDCPSKYPWIGDAEGSGIVGRDNYVPDNGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1MNL6</accession>
    <name>A0A1Y1MNL6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Uridine diphosphate glucose pyrophosphatase NUDT14</fullName>
            <ecNumber evidence="9">3.6.1.45</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Nucleoside diphosphate-linked moiety X motif 14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PPYR_06131</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Hydrolyzes UDP-glucose to glucose 1-phosphate and UMP and ADP-ribose to ribose 5-phosphate and AMP. The physiological substrate is probably UDP-glucose. Poor activity on other substrates such as ADP-glucose, CDP-glucose, GDP-glucose and GDP-mannose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>UDP-sugar + H2O = UMP + alpha-D-aldose 1-phosphate.</text>
            <dbReference type="EC" id="3.6.1.45"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.6.1.45" evidence="9"/>
    <dbReference type="EMBL" id="GEZM01026068">
        <property type="protein sequence ID" value="JAV87263.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01026067">
        <property type="protein sequence ID" value="JAV87264.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000004">
        <property type="protein sequence ID" value="KAB0800391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1MNL6"/>
    <dbReference type="FunCoup" id="A0A1Y1MNL6">
        <property type="interactions" value="372"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1MNL6"/>
    <dbReference type="OrthoDB" id="10249920at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008768">
        <property type="term" value="F:UDP-sugar diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006753">
        <property type="term" value="P:nucleoside phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019693">
        <property type="term" value="P:ribose phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18887">
        <property type="entry name" value="NUDIX_UGPPase_Nudt14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000035">
        <property type="entry name" value="Uridine diphosphate glucose pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004385">
        <property type="entry name" value="NDP_pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00052">
        <property type="entry name" value="nudix-type nucleoside diphosphatase, YffH/AdpP family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11839">
        <property type="entry name" value="UDP/ADP-SUGAR PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11839:SF15">
        <property type="entry name" value="URIDINE DIPHOSPHATE GLUCOSE PYROPHOSPHATASE NUDT14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="12">
        <location>
            <begin position="38"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00051086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00054674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00066480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00071467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00080475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="JAV87264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAB0800391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="204" mass="23229" checksum="39336C4449AB743D" modified="2017-08-30" version="1">MNKLCDVFFQPMKDSIYIKPFTMYFTLNGIKRNWDLMEVHDSVSILIYNVTRKVLIFVKQFRPAVYYGKIPSQERAGNVDVQKYPAELGVTIELCAGIVDKDLPLVEIAREEVLEECGYDVPISSLKKIASYQSGVGATSSKQIAFYCEVTDDMKIHEGGGVDDESIEVIEMTVDQVMDYVSKEHILSPPSFLFCVQWFLRSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1MQH3</accession>
    <name>A0A1Y1MQH3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Medium-chain specific acyl-CoA dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="5">1.3.8.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PPYR_14039</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="20 21" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">1611_PpyrPB1</strain>
            <tissue evidence="20">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">1611_PpyrPB1</strain>
            <tissue evidence="20">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a medium-chain 2,3-saturated fatty acyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = a medium-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:14477"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:83723"/>
            <dbReference type="ChEBI" id="CHEBI:83726"/>
            <dbReference type="EC" id="1.3.8.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; mitochondrial fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.8.7" evidence="5"/>
    <dbReference type="EMBL" id="GEZM01027474">
        <property type="protein sequence ID" value="JAV86725.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1MQH3"/>
    <dbReference type="FunCoup" id="A0A1Y1MQH3">
        <property type="interactions" value="623"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1MQH3"/>
    <dbReference type="OrthoDB" id="434771at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070991">
        <property type="term" value="F:medium-chain fatty acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051793">
        <property type="term" value="P:medium-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000010">
        <property type="entry name" value="Medium-chain specific acyl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000011">
        <property type="entry name" value="Medium-chain specific acyl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000007">
        <property type="entry name" value="Medium-chain specific acyl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050741">
        <property type="entry name" value="Acyl-CoA_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083:SF2">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15" id="KW-0274">FAD</keyword>
    <keyword evidence="9" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="7 15" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="18">
        <location>
            <begin position="40"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="17">
        <location>
            <begin position="155"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="16">
        <location>
            <begin position="265"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="JAV86725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAB0792078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="421" mass="45867" checksum="2A9A94D0FD9649B2" modified="2017-08-30" version="1">MQQLQKIIRTVHRPLLRASSTAAKTEPNASSSLGYNFALSDTQTEVQELARKFTREEITPMAAHYDKTGEFPWPIFKKAWSLGLANGHIPADCGGLEQSVFDLCLVAEEMAFGCTGIGVAIGGSGLAQTPIVLAASPEQKKKYLGRLIEEPLIAAYCVTEPGAGSDVNGVKTKAEKKGDEWILNGQKMWITGGGVANWYFVLARTNPDPKAPASRAFTAFIVERDWPGVTVGRKEINMGQRASDTRGITFEDVRVPKENVIMGEGAGFKIAMGVFDKTRPLVASGATGLANRALYEASKYATERRTFGVPIASHQAIAFMLADMAIGVETSRLLWMKSAWIVDQGQRNSYEASIAKCFSGDVANKNAADAVQIFGGNGFNTEYPVEKLMRDAKIYQIYEGTSQIQRLVISRHLLDSIKKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1MRS0</accession>
    <name>A0A1Y1MRS0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CCZ1/INTU/HSP4 first Longin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PPYR_14774</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCZ1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01023421">
        <property type="protein sequence ID" value="JAV88394.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1MRS0"/>
    <dbReference type="FunCoup" id="A0A1Y1MRS0">
        <property type="interactions" value="2502"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1MRS0"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035658">
        <property type="term" value="C:Mon1-Ccz1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013176">
        <property type="entry name" value="Ccz1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043987">
        <property type="entry name" value="CCZ1/INTU/HSP4_longin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043989">
        <property type="entry name" value="CCZ1/INTU/HSP4_longin_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043988">
        <property type="entry name" value="CCZ1/INTU_longin_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13056">
        <property type="entry name" value="VACUOLAR FUSION PROTEIN CCZ1 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13056:SF0">
        <property type="entry name" value="VACUOLAR FUSION PROTEIN CCZ1 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19031">
        <property type="entry name" value="Intu_longin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19032">
        <property type="entry name" value="Intu_longin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19033">
        <property type="entry name" value="Intu_longin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCZ1/INTU/HSP4 first Longin" evidence="2">
        <location>
            <begin position="9"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="CCZ1/INTU second Longin" evidence="3">
        <location>
            <begin position="204"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="CCZ1/INTU/HPS4 third Longin" evidence="4">
        <location>
            <begin position="356"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF19033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="JAV88394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0792815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="465" mass="53076" checksum="4041775DBAEA8118" modified="2017-08-30" version="1">MMAKSEIELKNFFIFSSSYESKEGEEYNKVLYYYPPTDDINTQVNNVGLVEAIIKFTGNFKPSGPLNSLHTLKKRQLYFEPEPNYWMVITINLPFINKGSNESTVVEYIEEDVHDTIYKAVLKQAYAMYRLFSGTYTSTEREYSITALRNKFEHFYTAYLKTLNLSNCDILNVFSGIHFLPLDKQNFLNVQCFINALECNYPIIEYVSFLFNDSLIWSGIEPDDTQIIYQYLISTLLPANIETELQGGSIPRNPSSPFASLHYGRFITGPTNLKTAHTIGKVPKIFLNNEANPSVYYFIVYRALNATICLFVNGGVDLTVELFKELDAFMGQRLSSIASDIGEYCTRSIIPPSSSDTSPRFIYFNKLNLAYKSTIHLDNRQSGNVSCGKELVQIMADMNSRKESLSFAGETIVKTMNDYWVVGKVSNLREFYVALQHKNASLIDISDEVKKICDTELKGIFFHPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1MTG2</accession>
    <name>A0A1Y1MTG2_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pleiotrophin/Midkine C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PPYR_09856</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pleiotrophin family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01021515">
        <property type="protein sequence ID" value="JAV88964.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01021514">
        <property type="protein sequence ID" value="JAV88965.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0795795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1MTG2"/>
    <dbReference type="FunCoup" id="A0A1Y1MTG2">
        <property type="interactions" value="33"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1MTG2"/>
    <dbReference type="OrthoDB" id="8818336at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008201">
        <property type="term" value="F:heparin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048332">
        <property type="term" value="P:mesoderm morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.90.10:FF:000001">
        <property type="entry name" value="Pleiotrophin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.90.10">
        <property type="entry name" value="Heparin-binding Growth Factor, Midkine, Chain A- C-terminal Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020090">
        <property type="entry name" value="PTN/MK_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038130">
        <property type="entry name" value="PTN/MK_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020091">
        <property type="entry name" value="PTN/MK_diS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21050">
        <property type="entry name" value="MIDKINE AND PLEIOTROPHIN 1, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21050:SF1">
        <property type="entry name" value="MIDKINE AND PLEIOTROPHIN 1, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01091">
        <property type="entry name" value="PTN_MK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57288">
        <property type="entry name" value="Midkine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011907501" description="Pleiotrophin/Midkine C-terminal domain-containing protein" evidence="7">
        <location>
            <begin position="20"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Pleiotrophin/Midkine C-terminal" evidence="8">
        <location>
            <begin position="87"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="108"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="115"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="JAV88964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0795795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="146" mass="16745" checksum="B13D9E6D007280FC" modified="2017-08-30" version="1">MKWLAFCVLTVVLVTLAVADGEIWEEDDHEVLIRSERGAKNREPCRYVKGSWSECDSKTNMRARTLTLKKGDQATCESTKTIQKKCKKACRYEKGTWGECNAQSQMTRNDKLKTNSDPSCEQNRQITKKCKPKGVKPTKATRRNRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1MTK4</accession>
    <name>A0A1Y1MTK4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Kinesin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PPYR_08948</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01024261">
        <property type="protein sequence ID" value="JAV87820.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="FunCoup" id="A0A1Y1MTK4">
        <property type="interactions" value="775"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1MTK4"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22708">
        <property type="entry name" value="FHA_KIF16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01365">
        <property type="entry name" value="KISc_KIF1A_KIF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000044">
        <property type="entry name" value="Kinesin-like protein KIF16B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000021">
        <property type="entry name" value="kinesin-like protein KIF16B isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.20:FF:000042">
        <property type="entry name" value="Kinesin-like protein Klp98A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47117:SF6">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF16B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47117">
        <property type="entry name" value="STAR-RELATED LIPID TRANSFER PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 5" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="8">
        <location>
            <begin position="3"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="9">
        <location>
            <begin position="1060"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="896"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="363"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="579"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="820"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="922"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="98"/>
            <end position="105"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="JAV87820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0797955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1193" mass="135188" checksum="4ACB277198FD04BE" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1MWD3</accession>
    <name>A0A1Y1MWD3_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_00458</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
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                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
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            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
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                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
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            <strain evidence="4">1611_PpyrPB1</strain>
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        </source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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</entry>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
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                <person name="Day J.C."/>
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                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
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                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
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                <person name="Oba Y."/>
                <person name="Weng J.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
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        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
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                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
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        </source>
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        <property type="project" value="UniProtKB-KW"/>
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    <feature type="binding site" evidence="3">
        <location>
            <position position="87"/>
        </location>
        <ligand>
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        </ligand>
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    <feature type="binding site" evidence="3">
        <location>
            <position position="89"/>
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        <ligand>
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    <feature type="binding site" evidence="3">
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            <position position="109"/>
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        <ligand>
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    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="111"/>
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        <ligand>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        <source>
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        <source>
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        <source>
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        </source>
    </evidence>
    <sequence length="123" mass="13707" checksum="27408C3C120C01DE" modified="2017-08-30" version="1">MASICRTLAISSSLRNTILYPSIRGTATKVTLGDPVEHATGLEKRELLAKLAGNDDPFDMKVMKRGPGTKTQPNQIPSAYDARIVGCICEEDATCINWMWLYKGKPRRCECGHWFSLVHKDPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1NKW0</accession>
    <name>A0A1Y1NKW0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GOLD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_04816</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heparin-binding growth factors family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01002394">
        <property type="protein sequence ID" value="JAV97275.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1NKW0"/>
    <dbReference type="InParanoid" id="A0A1Y1NKW0"/>
    <dbReference type="OrthoDB" id="5988014at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23307">
        <property type="entry name" value="beta-trefoil_FGF8-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002209">
        <property type="entry name" value="Fibroblast_GF_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008996">
        <property type="entry name" value="IL1/FGF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00167">
        <property type="entry name" value="FGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50353">
        <property type="entry name" value="Cytokine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036312600" description="GOLD domain-containing protein" evidence="2">
        <location>
            <begin position="33"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="JAV97275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0802630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="222" mass="25402" checksum="16D42AE8B9BCC1DC" modified="2017-08-30" version="1">MNPYVSTISQLLVVSALRTLILMVLISGVVHSGPVHHQKTCGDLQPIKPAAFYNSCSKKYLRVNNKDIVADTDTNNTLFTITVNNSHGFLLFDPIANMFVCWKYNKKTSRLVPKRNPKDISLCIFEELPTDGAYTKYVSTKNRSYVMSFKSNGQQRIGKKSNVKKRSKCQPEAFMRVSKQNGSNCSSTYNDFCERMKRIKRHKVREEIRQLCAIDNSVHRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1NMV7</accession>
    <name>A0A1Y1NMV7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cation/H+ exchanger transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PPYR_08229</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01001567">
        <property type="protein sequence ID" value="JAV97666.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1NMV7"/>
    <dbReference type="InParanoid" id="A0A1Y1NMV7"/>
    <dbReference type="OrthoDB" id="423807at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051843">
        <property type="entry name" value="CPA1_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31102">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31102:SF1">
        <property type="entry name" value="CATION_H+ EXCHANGER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="258"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="293"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="351"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="382"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="412"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="448"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="485"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="8">
        <location>
            <begin position="123"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="545"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="JAV97666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0797235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="566" mass="61963" checksum="41757FA20C03AECE" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N3ZY85</accession>
    <name>A0A5N3ZY85_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_15687</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01002059">
        <property type="protein sequence ID" value="KAB0790018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N3ZY85"/>
    <dbReference type="InParanoid" id="A0A5N3ZY85"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33395:SF22">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33395">
        <property type="entry name" value="TRANSCRIPTASE, PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0790018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="133" mass="15437" checksum="5AB0E5C858699EA2" modified="2020-02-26" version="1">MNLRLDPEEPNFYFYMPYSTETQIEELIKNLKTNTAPGNDNIRPIDIKSNSQIFSKLISRIINLSLRKGIFPEELKVSITRPIFKKGDANDVNNYRPISILPVIEKIFEGYVVAHLRRYTGCYTTVRKKKIGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N3ZYC6</accession>
    <name>A0A5N3ZYC6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_15613</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01001983">
        <property type="protein sequence ID" value="KAB0790067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N3ZYC6"/>
    <dbReference type="FunCoup" id="A0A5N3ZYC6">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N3ZYC6"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF269">
        <property type="entry name" value="NUCLEASE HARBI1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="8">
        <location>
            <begin position="110"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0790067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="307" mass="34673" checksum="85999EC7391588C4" modified="2020-02-26" version="1">MSAVQVQFLINLIGPQIVKQDTIMRSAIPVYERVMVTLRFLATGDSYSSLQYLFRIPVCTIGRIVKEVTVAIYEMLKESYLKFPNTKNEWLCIANSFNSRWNFPHCVGAVDGKQVSIQNPHNSGSHYFNYKGTYSIILLAVADASYKLIYFDVGCNGRISDGGVFQNSSLHQGLEDGSIELPEPTPLPGRTDPVPYCFVGDDAFAMKPYMLKPYPYQNQPAPNRIFNYRLSRARRIIENVFGIMANKFRVLRKPIALAPETVSTTVQAICALHNYLLSDKTLKGNYIHQDLIDTENTETHTLIPGSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N3ZYL6</accession>
    <name>A0A5N3ZYL6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BESS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_15538</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01001851">
        <property type="protein sequence ID" value="KAB0790138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N3ZYL6"/>
    <dbReference type="InParanoid" id="A0A5N3ZYL6"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004210">
        <property type="entry name" value="BESS_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02944">
        <property type="entry name" value="BESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51031">
        <property type="entry name" value="BESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BESS" evidence="3">
        <location>
            <begin position="133"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="46"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="197"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="55"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="85"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0790138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="226" mass="25189" checksum="0E81D9A74B9F018C" modified="2020-02-26" version="1" fragment="single">TQLKAKWKNIKDSFKKSVKTKSGAAAPKKSYVHFEALSFLLNSAEKRGTSGNYEGGHENSADEEGRSRSPIRSTSSSAVEDAEASQHTPRSTLYQTQKKSSLPPKMTAFQNSLLQTLGTASTLLHKSQVPEPEDPDRQYLLSLLPDYKNLPLDKKWEFRQHVVNFFKHTYSSAPTPPLQPFTHNPLSAFYTSPTGTPTSHYHNFPSTSSSHPPSHPSHDPVSPEWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N3ZYV7</accession>
    <name>A0A5N3ZYV7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_15404</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01001586">
        <property type="protein sequence ID" value="KAB0790255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N3ZYV7"/>
    <dbReference type="InParanoid" id="A0A5N3ZYV7"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0790255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="342" mass="39092" checksum="A1BCB7F122810F3A" modified="2020-02-26" version="1" fragment="single">MPLSRTPSNKNQANMETEEEVAGGYSLRSKSKVANIPKANEKHLGAIPKVYYKQGHLSDGTINEGRRSLFNSSQNEVSQNPQGQHGTDISIWEKHEEFRLPDLFTTPTGMQAKFFKSKGEVADTRIWPGAISCEALENQMLQDLTPEMRSRSSYHIQDLKYDEKRQDPNDTGNPDLPSQVITNQNRENSGTKVKHDNFINTSCGNTQTDMVDLVTQIVSALAKMNVIQGNDKSRQVIEQNVKSTGSLDLVKKLPSFDGSENSHPMEFITQIEYFYRFEKISFECLRFLLANQFKGSAMLWSRAYLNSFTDFETFKQGFKEQYWSETKQLEIRLKLQSARYPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N3ZZ05</accession>
    <name>A0A5N3ZZ05_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_15356</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="VVIM01001522">
        <property type="protein sequence ID" value="KAB0790305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A5N3ZZ05">
        <property type="interactions" value="1961"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N3ZZ05"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000080">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2230.10">
        <property type="entry name" value="DUSP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035927">
        <property type="entry name" value="DUSP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006615">
        <property type="entry name" value="Pept_C19_DUSP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF76">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06337">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00695">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143791">
        <property type="entry name" value="DUSP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51283">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="29"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="DUSP" evidence="8">
        <location>
            <begin position="152"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="7">
        <location>
            <begin position="509"/>
            <end position="1319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1109"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1228"/>
            <end position="1248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="261"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1133"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0790305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1357" mass="152368" checksum="8EE3AB177BA111C5" modified="2020-02-26" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N3ZZ90</accession>
    <name>A0A5N3ZZ90_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_15247</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01001386">
        <property type="protein sequence ID" value="KAB0790383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N3ZZ90"/>
    <dbReference type="InParanoid" id="A0A5N3ZZ90"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33480">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33480:SF1">
        <property type="entry name" value="TYR RECOMBINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0790383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="601" mass="69020" checksum="A62999E0D9821D32" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2024-03-27" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N3ZZP2</accession>
    <name>A0A5N3ZZP2_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_15075</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01001156">
        <property type="protein sequence ID" value="KAB0790526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N3ZZP2"/>
    <dbReference type="InParanoid" id="A0A5N3ZZP2"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35617:SF3">
        <property type="entry name" value="CORE-BINDING (CB) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35617">
        <property type="entry name" value="PHAGE_INTEGRASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0790526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="225" mass="25149" checksum="F2CCE24DEC954F51" modified="2020-02-26" version="1">MKLHLKNGGTSVHRDVWIPSQRTFRLLQHPRCDNMKLHLKNALQFDQGIGYSTICSARSALSLLISPEVGEDAKVKRLIKGVFNLRAPAPKYNSTWDPGLVLQYLGSLYPNNVISIQLLSVKLITLLALVTAHRLQTFSVIQITNIEHKADGIEIKIPARIKTSSIGNCQPALFLPFFVDKPEVCAASALEMYLSRTKPIRGTLDKLFRNLCSDVESLGKDWAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N3ZZS5</accession>
    <name>A0A5N3ZZS5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_15035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01001121">
        <property type="protein sequence ID" value="KAB0790563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N3ZZS5"/>
    <dbReference type="InParanoid" id="A0A5N3ZZS5"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058913">
        <property type="entry name" value="Integrase_dom_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46791:SF13">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46791">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24764">
        <property type="entry name" value="rva_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase core" evidence="1">
        <location>
            <begin position="135"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0790563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="395" mass="46633" checksum="D1DC55D03E639B75" modified="2020-02-26" version="1">MYESVEGPQSQLIMERDNLIRSYFSLGLHYSEILSLLLIQHNIILSERQLKRILRRLNLTRRKNFSSFEEIFLFIEELLEGSGRFHGYRWIHLKCLQRGLVVKQETVRLLLKILDPTGVSTRRRRRLRRRDYFNKGPNYLWHMDGYDKLKPYGIAISGCIDGFSRYIIWLQASYTNNNPRIISGYYISAVESCGGCPRSVRSDLGTENRHVEQMQIFLRNNLESDDSLPPFIYGSSTHNQRIEAWWGILRKHNAQFWMDIFEDLKNEGKFSGTILDKALVQYCFLHLVQGQLDQVVQEWNSHKISSRNRRSPVGKPIIMYYTPEMYYARDYIVKSPEDAILSCREESLFPLVHCDQDVYELCQILSEENHYERPSTAYEATDLYIQLRNDILSML</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N3ZZX0</accession>
    <name>A0A5N3ZZX0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_14938</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01001004">
        <property type="protein sequence ID" value="KAB0790624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N3ZZX0"/>
    <dbReference type="InParanoid" id="A0A5N3ZZX0"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF269">
        <property type="entry name" value="NUCLEASE HARBI1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="8">
        <location>
            <begin position="42"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0790624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="255" mass="29440" checksum="69E3782156FD8251" modified="2020-02-26" version="1" fragment="single">VCRNIWIHMKDMCMEQLTEDKWKDIINRFKQTAKFPNCLGAVDGKHIRIIQPAQSGSAYYNCKNYFSIILLADIGSYGRHADSAISEESCLYKMLREKKLNIPPPSTISQNGPLLPNVFIGDEAFSLQENLMRPYGGKNLAEKKLIFNYRLSRARRYIECTFGILANKWRIFHRPLNVSVDFAVDIVKSSCVLHNYVKQRDGNKLEDTFEGLPHSIIHSTQQVRPGGPMLTTIREEFANYFVSEEGKLDWQWNMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N3ZZX7</accession>
    <name>A0A5N3ZZX7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">YqaJ viral recombinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_14993</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01001047">
        <property type="protein sequence ID" value="KAB0790599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N3ZZX7"/>
    <dbReference type="InParanoid" id="A0A5N3ZZX7"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd22343">
        <property type="entry name" value="PDDEXK_lambda_exonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051703">
        <property type="entry name" value="NF-kappa-B_Signaling_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019080">
        <property type="entry name" value="YqaJ_viral_recombinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46609">
        <property type="entry name" value="EXONUCLEASE, PHAGE-TYPE/RECB, C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46609:SF8">
        <property type="entry name" value="YQAJ VIRAL RECOMBINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09588">
        <property type="entry name" value="YqaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YqaJ viral recombinase" evidence="1">
        <location>
            <begin position="41"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0790599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="259" mass="29450" checksum="14EA0FD6CEA74ABC" modified="2020-02-26" version="1">MEDMDEGIYIVKKQEFLTELKKEIPIDIQRLTIGQSNNPLWKVMRLKRLTASNFGKVAKLRPTTSTANIVKALLYQGDWGNTATQYGNENEQRAIQDFELITGLKVSPCGLFIDENNSFLAASPDGLVSDEALLEVKCPYNARFSTPEEATKNGTIKCLTLSNGDLHLKENHDYMYQIQGQMQICQKKICYFVVWTPQQTFDQEIVKDDTFWAKMVPKLTAFYELALLPELIDSRKSRGHDIRSTALGNISDFSSDFTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A0K3</accession>
    <name>A0A5N4A0K3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transposase Helix-turn-helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_14918</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000708">
        <property type="protein sequence ID" value="KAB0790842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A0K3"/>
    <dbReference type="InParanoid" id="A0A5N4A0K3"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0790842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="140" mass="16141" checksum="4384DE3F70E30F13" modified="2020-02-26" version="1">MDVEEIVLITLIIGASAALLLNRKRRWWVRPWIEQRETNSQGNSNLLDNELAVLDKENYKNFIRMDEDTFNDLLKLIENDIQKQDTKFRNAISAKDRLSVTLRYLATGESYKSLSFSFRMGQSTIAGIIPEVDTATLDNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A0X0</accession>
    <name>A0A5N4A0X0_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_02774</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0790974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A0X0"/>
    <dbReference type="InParanoid" id="A0A5N4A0X0"/>
    <dbReference type="OrthoDB" id="10475206at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024387917" evidence="1">
        <location>
            <begin position="19"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0790974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="314" mass="36387" checksum="E783C2A528D4B9B8" modified="2020-02-26" version="1">MAKLVLVLLAAFANQVLTSTHTNYDLDNYLTEIKTEIRDLTVYLEDVFPGNHHAITTVTWQCHRVAEAIKNVVTKLSDETTKQHESGEIIFKQLWFALQEVHTSLQQIALSSDVTDVSEIKKQLILTLQLVTETFEKMMHVTYVHYPEFRATLKTIFGDYLAAIRDIRRAFETEHHDGAQRVSAKYLAMDITRFSQKVRYNLKEAAQGNFAWFYEGVGKIVRELETRDSVGDDEIDVVLRNLKMKLSKLEHDKDFGDVATLCVQLVHFVENGSQHERADRFIQKVIYDYLGLVRRLSEGLDSEQQHRHSFDRHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-06-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A1C6</accession>
    <name>A0A5N4A1C6_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_02927</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A1C6"/>
    <dbReference type="InParanoid" id="A0A5N4A1C6"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0791127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="118" mass="13550" checksum="1CC5B6F9B98C29C8" modified="2020-02-26" version="1">MAINGNFLKYILNYRHNLLSSLLTKECNLPVLYKSQKTFLHFQNCGMHTLQHKQPRAKTRRTHLSPHNAKQTTTAVIGQAFYKAIRKPCITHLIIVLSTIAEVAEEVILRRLQGPTEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A1G2</accession>
    <name>A0A5N4A1G2_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PPYR_02963</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A1G2"/>
    <dbReference type="InParanoid" id="A0A5N4A1G2"/>
    <dbReference type="OrthoDB" id="66620at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047817">
        <property type="entry name" value="ABC2_TM_bact-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43038:SF3">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 20 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43038">
        <property type="entry name" value="ATP-BINDING CASSETTE, SUB-FAMILY H, MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12698">
        <property type="entry name" value="ABC2_membrane_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="506"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="546"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="579"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="614"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="666"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="25"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-2" evidence="9">
        <location>
            <begin position="467"/>
            <end position="696"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0791163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="697" mass="78395" checksum="2C0B187A5A151889" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A1I1</accession>
    <name>A0A5N4A1I1_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_02956</name>
        <name evidence="3" type="ORF">PPYR_08698</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A1I1"/>
    <dbReference type="InParanoid" id="A0A5N4A1I1"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0791156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0797705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="182" mass="20936" checksum="98AEBD7D8EFAE222" modified="2020-02-26" version="1">MLLDLYEQWMGQVGPLKKFKTKKVMWVNIAERINKYFHTGKTGLQCENRYKTVLKRKKAAVENNMTSGSSRALVPFENELNKISASDDSIQPEVTGSSRGVTIIKRKRETSLSEEPVAECSSDDMPSTSHTPQQKTKNKTIQETLLQIFEVKEKARERRHREKLQLIKQILGKENLEENVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A1I8</accession>
    <name>A0A5N4A1I8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PPYR_02990</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">1611_PpyrPB1</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A1I8"/>
    <dbReference type="FunCoup" id="A0A5N4A1I8">
        <property type="interactions" value="66"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A1I8"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11056">
        <property type="entry name" value="CYP6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000042">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050476">
        <property type="entry name" value="Insect_CytP450_Detox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292:SF54">
        <property type="entry name" value="CYP9F3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0492">Microsome</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="471"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAB0791190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="528" mass="61540" checksum="216ADBCE24071252" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A1Z9</accession>
    <name>A0A5N4A1Z9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_03088</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A1Z9"/>
    <dbReference type="InParanoid" id="A0A5N4A1Z9"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061762">
        <property type="term" value="P:CAMKK-AMPK signaling cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895">
        <property type="entry name" value="CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895:SF164">
        <property type="entry name" value="CALCIUM_CALMODULIN-DEPENDENT PROTEIN KINASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0791288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="276" mass="31237" checksum="9859F1B4A9AAE8D0" modified="2020-02-26" version="1">MFATQFELKGEPFDGGLIAMKILSKKKLVKKAGMFGRLPPRWIAKSCDSEMLTPLQRVYREIAVLKKLDHPNVVKLVEVLDDPEEDQLYLVFELLEKPILNVPTDEPLSENNTWHYFRDVILGIEYLHYQRIIHRDIKPANLLLTDSGRVQVADLGVCNEFDGSDAYLSTTVGTPAFIPPEALREGQNDGFSGKAADIWSMGVTLYSLVYGRTPFIEENIISLYSRIKSHPVEFPATPHISSSLRNLILSMLVKDPKQRITLPEIKVSIVTYPLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A253</accession>
    <name>A0A5N4A253_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">LRRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PPYR_03197</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A253"/>
    <dbReference type="InParanoid" id="A0A5N4A253"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000483">
        <property type="entry name" value="Cys-rich_flank_reg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050541">
        <property type="entry name" value="LRR_TM_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369">
        <property type="entry name" value="ANTIGEN BSP, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369:SF210">
        <property type="entry name" value="CHAOPTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00082">
        <property type="entry name" value="LRRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024289613" description="LRRCT domain-containing protein" evidence="4">
        <location>
            <begin position="21"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="LRRCT" evidence="5">
        <location>
            <begin position="207"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0791397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="254" mass="28875" checksum="C87ABC0796759C2F" modified="2020-02-26" version="1">MMSTLFLGALLFCSVISVRSLCESPCSCKLIDKKSTASCSNVNLKTIPRTLDPDSEELDLSHNSLARLPDNVFRDVDLLNLQTVDLHANKISEIGEDAFRGVTNLRKLDLSDNKLATMRPGTIPRWVLHLNLNGNPLRRLEPNNFLSSPLLRQLHLERCEIDSIHPNALIEATGLQVISLRNNQLKNLNETVFKEQRQLVTLRLEGNPWDCDCSLRRFRDWYYKYDEGTVTCQSPKSLNGTVWKGLTSFDFVCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A2Z5</accession>
    <name>A0A5N4A2Z5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Phosphoglycerate kinase</fullName>
            <ecNumber evidence="4 14">2.7.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PPYR_03472</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">1611_PpyrPB1</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:14801"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the phosphoglycerate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.3" evidence="4 14"/>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A2Z5"/>
    <dbReference type="FunCoup" id="A0A5N4A2Z5">
        <property type="interactions" value="517"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A2Z5"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004618">
        <property type="term" value="F:phosphoglycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00318">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1260:FF:000005">
        <property type="entry name" value="Phosphoglycerate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1260:FF:000032">
        <property type="entry name" value="Phosphoglycerate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1260:FF:000031">
        <property type="entry name" value="Phosphoglycerate kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1260">
        <property type="entry name" value="Phosphoglycerate kinase, N-terminal domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00145">
        <property type="entry name" value="Phosphoglyc_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001576">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015911">
        <property type="entry name" value="Phosphoglycerate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015824">
        <property type="entry name" value="Phosphoglycerate_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036043">
        <property type="entry name" value="Phosphoglycerate_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406">
        <property type="entry name" value="PHOSPHOGLYCERATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406:SF0">
        <property type="entry name" value="PHOSPHOGLYCERATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00162">
        <property type="entry name" value="PGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000724">
        <property type="entry name" value="Pgk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00477">
        <property type="entry name" value="PHGLYCKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53748">
        <property type="entry name" value="Phosphoglycerate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00111">
        <property type="entry name" value="PGLYCERATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="8 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="23"/>
            <end position="25"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>(2R)-3-phosphoglycerate</name>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="62"/>
            <end position="65"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>(2R)-3-phosphoglycerate</name>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>(2R)-3-phosphoglycerate</name>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="371"/>
            <end position="374"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAB0791672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="416" mass="44494" checksum="1DDF576166921EDD" modified="2020-02-26" version="1">MALHKLSIDALNLAGKRVLMRVDFNVPLKDGVITNNQRIVAALDTIKYAIEKSAKSIVLMSHLGRPDGTANLKYTLKPVADELSKLLSRNVDFLPDCVGSQIESACADPKPGSIILLENLRFHVEEEGKGIDASGNKVKADPAKVKEFRSSLRKLGDVYVNDAFGTAHRAHSSMLGEGFEERASGFLLKKELQYFAKALDNPEKPFLAILGGAKVADKIQLIENLLDKVDEMIIGGGMSYTFLKESQNMSIGNSLYDAEGAKIVQKLLDKAKANNVKIHLPVDFVTANKFAENANVGSATAAEGIPEGLMGLDIGPKSLELFREPIKRAKVIVWNGPAGVFEFENFAKGTKGLMDAVVDATSKGTVSIIGGGDTATCCAKWNTEDKVSHVSTGGGASLELLEGKVLPGVAALTDAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A302</accession>
    <name>A0A5N4A302_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Purple acid phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_03505</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.2" evidence="3"/>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A302"/>
    <dbReference type="InParanoid" id="A0A5N4A302"/>
    <dbReference type="OrthoDB" id="45007at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00839">
        <property type="entry name" value="MPP_PAPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.380">
        <property type="entry name" value="Purple acid phosphatase-like, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041792">
        <property type="entry name" value="MPP_PAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025733">
        <property type="entry name" value="PAPs_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015914">
        <property type="entry name" value="PAPs_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008963">
        <property type="entry name" value="Purple_acid_Pase-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45867:SF3">
        <property type="entry name" value="ACID PHOSPHATASE TYPE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45867">
        <property type="entry name" value="PURPLE ACID PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14008">
        <property type="entry name" value="Metallophos_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16656">
        <property type="entry name" value="Pur_ac_phosph_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49363">
        <property type="entry name" value="Purple acid phosphatase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024468886" description="Purple acid phosphatase" evidence="3">
        <location>
            <begin position="17"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="Purple acid phosphatase N-terminal" evidence="6">
        <location>
            <begin position="29"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="4">
        <location>
            <begin position="133"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="Purple acid phosphatase C-terminal" evidence="5">
        <location>
            <begin position="362"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0791705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="434" mass="50307" checksum="9BC142C70F2E0779" modified="2020-02-26" version="1">MWRFLLVLSSAVCINCKIVPITNHVPMQPEQVHIAYGDSVYEIVATWSTVGDTKESIVEYGTGFQSLNYTAAGSSRLFTDGGRKGRSQYVHSVTLKNLRPSTVYVYHVGSRFGWSNEFLFRTPPVVERWQPSLAIFGDMGLENAQSLARLEEDTHRGMYDAILHVGDFAYDMNSHNGVVGDKFMKLIEPIAAYVPYMTCVGNHEERYNFSHYKMRFNMPGDTENLMFSFNMGPLHIISISTEVYYFLNYGIKSLVFQYEWLENDLREATDPKNRRERPWIIVMGHRPMYCSNTDPADCAHNSTFTRVGIPFFHMFGLEKLFYDNKVDVLIWAHQHSYERLWPIYDFKIFNGTYEQPYLNPLAPVHIITGSAGCKENHSHFDNDKPYWSAFRSTDYGYTRMKAYNKTHLYFEQVSDDQGGAVIDSFWIIQNKRSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A4Q6</accession>
    <name>A0A5N4A4Q6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transmembrane protein 208</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_14262</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM208 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A4Q6"/>
    <dbReference type="FunCoup" id="A0A5N4A4Q6">
        <property type="interactions" value="65"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A4Q6"/>
    <dbReference type="OrthoDB" id="10012212at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006624">
        <property type="term" value="P:vacuolar protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008506">
        <property type="entry name" value="SND2/TMEM208"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13505">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13505:SF7">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05620">
        <property type="entry name" value="TMEM208_SND2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="103"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0792303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="171" mass="19466" checksum="93C118FBFBFEEFA7" modified="2020-02-26" version="1">MAPQQKGKQATKGAKQIVEENVSTLNFYRNMAIASNATSLIILVFYNSPISIFLYLFSCFVYIASYQFMVYMAKTKHSETGQLVDSGVDLNMEGGIAEHVKDIIILTAGCQLLSSAISTYFWLLWLLAPARGFWLAWKNILAPYFFQEAPVDPAANEKKQKKLERRMRRHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A5D5</accession>
    <name>A0A5N4A5D5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_14494</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A5D5"/>
    <dbReference type="InParanoid" id="A0A5N4A5D5"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21245">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="8"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="91"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="188"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0792535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="475" mass="54399" checksum="C831C282DA761EF2" modified="2020-02-26" version="1">MKPPPLDNQVFVKDLPIDALEDEIFVHFSRAGQIYEIILMVDPDSEGVHNLGCAFIRYVDSEGAKNAVRHFHNFPFRLQRRVVVVKAIASKRVYIFGLPFSKCKTQIWDELIRKGLKNITDVIVHKPPATHKKNRGFIFVEFETHENAAFVRNKYYRNNPLHLFGRKCLVDWTSTTMTVDSEAMADVKRLFMRNLPRYLSRKDILEILYKLIDDMCCVEKIYKANQFAFIHFGTREMAETALLRLKRYFENTDVEITWCIPQEEEAKLEKTFRTQQKMFNILYLSSFEENYPLFSLDCLSSDSSGSSEGSSSPPRFPSDIVASVSQFKAILDSEQQSQQFRIESTYVCTQANEASPSESCCNISKFPLQQVVESLKKNILPQCEPSTSKSAQEQSAQEQIMAVVEGSEFAMPPPTTTWRRMDYTRNFGAPISGIQQPTEPSVAMARWSEGESAASSNEGLPSMINWWDLLTERDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A5Z3</accession>
    <name>A0A5N4A5Z3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">LIM homeobox transcription factor 1-beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PPYR_14691</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">1611_PpyrPB1</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A5Z3"/>
    <dbReference type="FunCoup" id="A0A5N4A5Z3">
        <property type="interactions" value="94"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A5Z3"/>
    <dbReference type="OrthoDB" id="10068367at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09371">
        <property type="entry name" value="LIM1_Lmx1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000227">
        <property type="entry name" value="LIM homeobox transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000006">
        <property type="entry name" value="LIM homeobox transcription factor 1-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000103">
        <property type="entry name" value="LIM homeobox transcription factor 1-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050453">
        <property type="entry name" value="LIM_Homeobox_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24208:SF166">
        <property type="entry name" value="LIM HOMEOBOX TRANSCRIPTION FACTOR 1 ALPHA, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24208">
        <property type="entry name" value="LIM/HOMEOBOX PROTEIN LHX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 9 11" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 10" id="KW-0440">LIM domain</keyword>
    <keyword evidence="2 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="13">
        <location>
            <begin position="42"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="13">
        <location>
            <begin position="102"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="14">
        <location>
            <begin position="185"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="9">
        <location>
            <begin position="187"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="169"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="244"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="332"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="176"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="249"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="288"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="341"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAB0792732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="386" mass="43687" checksum="B73B07E8A54375B8" modified="2020-02-26" version="1">MLEFYPNLNLNTAMLQEHSSMQGMECGGRSDASIIKCEKTYEMCEGCGQKIHDRYLMRVADASWHEHCLSCCVCGVLLNHSCYTRNTKLYCKADYDRIFGVKCSRCGDRILPHEMVMRAQQHVFHLACFVCVVCCQPLQKGEQFVLRAGQLFCRQDFEKEMYLMQQASSGDDDMLEEGRPRDGRRGPKRPRTILTSAQRRQFKASFEVSPKPCRKVREALAKETGLSVRVVQVWFQNQRAKMKKIQRKAKQEDGKSPSDKDKSDKDEKSIKQESPSSDQGHYLGLGSMSDSAFPTSSQPLNPNIPYSPDDAYPAHSGESFCSSDISLDGSTNFDHLDEATSDTLSLQNMELPTSHSRSHEPMSSGAITNPIDKLYLMQNSYFSTEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A711</accession>
    <name>A0A5N4A711_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 22">Angiotensin-converting enzyme</fullName>
            <ecNumber evidence="22">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">PPYR_12736</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">1611_PpyrPB1</strain>
            <tissue evidence="24">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>Release of a C-terminal dipeptide, oligopeptide-|-Xaa-Yaa, when Xaa is not Pro, and Yaa is neither Asp nor Glu. Thus, conversion of angiotensin I to angiotensin II, with increase in vasoconstrictor activity, but no action on angiotensin II.</text>
            <dbReference type="EC" id="3.4.15.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="22">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="22">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 21 22">Belongs to the peptidase M2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="22"/>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A711"/>
    <dbReference type="FunCoup" id="A0A5N4A711">
        <property type="interactions" value="51"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A711"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008241">
        <property type="term" value="F:peptidyl-dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06461">
        <property type="entry name" value="M2_ACE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1370.30:FF:000004">
        <property type="entry name" value="Angiotensin-converting enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001548">
        <property type="entry name" value="Peptidase_M2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10514">
        <property type="entry name" value="ANGIOTENSIN-CONVERTING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10514:SF44">
        <property type="entry name" value="ANGIOTENSIN-CONVERTING ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01401">
        <property type="entry name" value="Peptidase_M2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00791">
        <property type="entry name" value="PEPDIPTASEA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52011">
        <property type="entry name" value="PEPTIDASE_M2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 22" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="9 18 21" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10 14 22" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 22" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 17 22" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 22" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3 22" id="KW-0645">Protease</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 23" id="KW-0732">Signal</keyword>
    <keyword evidence="7 17 22" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="23">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024417040" description="Angiotensin-converting enzyme" evidence="23">
        <location>
            <begin position="19"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor 1" evidence="13">
        <location>
            <position position="371"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor 2" evidence="15">
        <location>
            <position position="371"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor 1" evidence="13">
        <location>
            <position position="501"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor 2" evidence="15">
        <location>
            <position position="501"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>chloride</name>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="370"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="370"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="374"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="374"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="398"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="398"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="510"/>
        </location>
        <ligand>
            <name>chloride</name>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="14">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="19">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine; partial" evidence="14">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="21">
        <location>
            <begin position="138"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18 21">
        <location>
            <begin position="339"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18 21">
        <location>
            <begin position="526"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00036868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00039858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR601548-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR601548-10"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR601548-11"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR601548-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR601548-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR601548-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR601548-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR601548-8"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU361144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KAB0793116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="617" mass="71560" checksum="0EE64F1EF5198C8D" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A7B1</accession>
    <name>A0A5N4A7B1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Runt domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_12830</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A7B1"/>
    <dbReference type="FunCoup" id="A0A5N4A7B1">
        <property type="interactions" value="44"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A7B1"/>
    <dbReference type="OrthoDB" id="10029800at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001709">
        <property type="term" value="P:cell fate determination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.720:FF:000001">
        <property type="entry name" value="Runt-related transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000040">
        <property type="entry name" value="AML1_Runt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012346">
        <property type="entry name" value="p53/RUNT-type_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013524">
        <property type="entry name" value="Runt_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11950">
        <property type="entry name" value="RUNT RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11950:SF31">
        <property type="entry name" value="SEGMENTATION PROTEIN RUNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00853">
        <property type="entry name" value="Runt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00967">
        <property type="entry name" value="ONCOGENEAML1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51062">
        <property type="entry name" value="RUNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Runt" evidence="6">
        <location>
            <begin position="13"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="275"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="339"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="275"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="292"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="364"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0793210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="388" mass="42856" checksum="0E6C3DA669500B91" modified="2020-02-26" version="1">MHLPPASIDMYANMQESLQEYHGELVQTGSPTVLCSALPNHWRSNKSLPIAFKVVALDDIQDGTVVTLRAGNDENYCAELRNCTAVMKNQVAKFNDLRFVGRSGRGKSFSLSIMISSSPFQVATYNKAIKVTVDGPREPRTKANFQYGYGIPGLPGAFNPFLLNPGWLDAAYMTYAWPDYFRTRPSFQQQNIHPGLIKGNSPQLPPSNLQGPGGDFYIPHGATPPGAFPPNYHSGGLLPQLPTESLPKVPQFDNFHIRTLPSSSPLDQLTMKLSPTSTDRTTVSPQMNRIRNLHDSPRIHSTVDHSNSENSDDEDIDVVKSAFQPIKPANILLQEIQHPDSTVQDKEPSAKLKSPASRKPHSPKSPSATKITHTPSQINATKNVWRPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A7L7</accession>
    <name>A0A5N4A7L7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">V-type proton ATPase subunit H</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PPYR_12946</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit H is essential for V-ATPase activity, but not for the assembly of the complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the V-ATPase H subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A7L7"/>
    <dbReference type="FunCoup" id="A0A5N4A7L7">
        <property type="interactions" value="2323"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A7L7"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00256">
        <property type="entry name" value="VATPase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000067">
        <property type="entry name" value="V-type proton ATPase subunit H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.150:FF:000001">
        <property type="entry name" value="V-type proton ATPase subunit H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.150">
        <property type="entry name" value="V-type ATPase, subunit H, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004908">
        <property type="entry name" value="ATPase_V1-cplx_hsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011987">
        <property type="entry name" value="ATPase_V1-cplx_hsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038497">
        <property type="entry name" value="ATPase_V1-cplx_hsu_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10698">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10698:SF0">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11698">
        <property type="entry name" value="V-ATPase_H_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03224">
        <property type="entry name" value="V-ATPase_H_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF032184">
        <property type="entry name" value="ATPase_V1_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase V1 complex subunit H C-terminal" evidence="7">
        <location>
            <begin position="346"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00046225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR032184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF11698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0793326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="485" mass="55943" checksum="71A36330CBFB691F" modified="2020-02-26" version="1">MSSSQVPAGANPKIKEMITSLDDDKIDMLAATSVLQQQATDIRTQHVNWQSYYQSQMISQEDHKFITAFDVSDSAAREKLLKTDRNQCARTFLNLLGHVSKDQTLQYILILIDDMLQEDRTRVEIFHEYAARTKESVWGPFLNLLNRQDGFITNMTARIIAKIACWAQTPMERSDLNFYLAWLKDQLKVQNNEYIQSVGRCLQMMLRIDEYRFAFVSVDGISTLLSVLSGRVNFQVQYQLIFCLWVLTFNPLLAEKMNKFNVIPFLADILSDSVKEKVTRIILAVFRNLIEKPEDSQVSKEHCIAMVQCKVLKQLTILEQRKYDDEDVSSDVEFLTEKLQSSVQDLSSFDEYATEVKSGRLEWSPVHKSKFWRENAQRLNEKNYELLRILVHLLETSKDALVLSVASFDIGEYVRHYPRGKHVIEQLGGKQLVMQLLAHEDPNVRYEALLAVQKLMVHNWEYLGKQLEKEQSGDSKAAPPISGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A8D7</accession>
    <name>A0A5N4A8D7_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_13211</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A8D7"/>
    <dbReference type="InParanoid" id="A0A5N4A8D7"/>
    <dbReference type="OrthoDB" id="6601693at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23992">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.20">
        <property type="entry name" value="Pheromone/general odorant binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006170">
        <property type="entry name" value="PBP/GOBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036728">
        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01395">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00708">
        <property type="entry name" value="PhBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024381982" evidence="1">
        <location>
            <begin position="17"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0793591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="125" mass="13680" checksum="AE15798E1D071047" modified="2020-02-26" version="1">MKIALIILLCFYATTSLQDSVREATVKANSKACSKELMVDTSLAKRALKSGNAGNDTTVKCFFKCVLEKDGTMTTTGELNLMPFRDRLVKATEMMDACSALKAETPCDLAFNAMTCIRNAFMSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A8N4</accession>
    <name>A0A5N4A8N4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_13303</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A8N4"/>
    <dbReference type="FunCoup" id="A0A5N4A8N4">
        <property type="interactions" value="90"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A8N4"/>
    <dbReference type="OrthoDB" id="10001938at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070888">
        <property type="term" value="F:E-box binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11421">
        <property type="entry name" value="bHLH_TS_ATOH8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000052">
        <property type="entry name" value="Protein atonal homolog 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032660">
        <property type="entry name" value="ATOH8_bHLH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050359">
        <property type="entry name" value="bHLH_transcription_factors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19290">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX PROTEIN NEUROGENIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19290:SF102">
        <property type="entry name" value="TRANSCRIPTION FACTOR ATOH8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="8">
        <location>
            <begin position="270"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="109"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0793683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="365" mass="41027" checksum="5AC650620B7244B4" modified="2020-02-26" version="1">MNERAYIFKFKFKIRVIWDFVMTAKGRDFELYSGGEEDEYLEVEVHSPTDSSEDSVEVKVSPICLRNKRKCAEPRKVQDAYTAPLKKRMCLQAKNEFASGNEPFRPWNAENSTTSSAPKQNLSKDLRVPSSITTDIKLATPDSNFVVPRPPDSDDKLLIRPCSSASPKNAQPALVPLSLVKKATNSSARSRKTKPEYSSIKTECEIPAPCDPLTLRVPLHPRISSLNATETEQYLANSAEAFPNLQSHRDEDHTAYGRKEQRNYKNMTRERRIEANARERTRVHTISAAFETLRKAVPAYSHNQKLSKLSVLRIACSYIMTLGKLAGNTVDSESGGSQSLAECVDTVSKTIQKEGKLRKKKDEID</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A9E5</accession>
    <name>A0A5N4A9E5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">STAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PPYR_13561</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A9E5"/>
    <dbReference type="FunCoup" id="A0A5N4A9E5">
        <property type="interactions" value="7"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A9E5"/>
    <dbReference type="OrthoDB" id="288203at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="SULFATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="216"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="382"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="411"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="SLC26A/SulP transporter" evidence="6">
        <location>
            <begin position="34"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="7">
        <location>
            <begin position="464"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0793941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="586" mass="64781" checksum="9517CBDAE7BD1A8F" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AC28</accession>
    <name>A0A5N4AC28_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_11701</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0794862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AC28"/>
    <dbReference type="InParanoid" id="A0A5N4AC28"/>
    <dbReference type="OrthoDB" id="7600531at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="346"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="46"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="139"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="22"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0794862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="366" mass="42910" checksum="CCB192C8FB120E25" modified="2020-02-26" version="1">MTKVLSNSKLSNPSKFIRKVLSRNNTDQVEPSTSSDSRNNHYDQELSSLREQVSILQLAVDSMQEDVEKKERALVNLEKEKQELYIHLKKEKRSSTNLKQQLQDERDFYFKEKEHYCQEMNDCRKLKKKLSESIITKHEKETNVEIRQYKSQISKLQDALNQTLEANYNLSVKFLRMKNTKSNLKHRLKQHDLDHQRAMEDLAHQVNDVKKSLEEITDKRFTLPISPSNRKYLQVIKENGLLMYDNMCLKMEVDRLTERIDRMKYVQSNNDLKQKYKFISRNAATQTGKHHPRNDLNCLEQEKADSKVIKVFERTETLGTPQIIMLGNDAPGIRTKLEDAEHRANNFEQCSSTSSSFRAQSAPDII</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ADQ2</accession>
    <name>A0A5N4ADQ2_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transmembrane protein 17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PPYR_12283</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0795444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ADQ2"/>
    <dbReference type="InParanoid" id="A0A5N4ADQ2"/>
    <dbReference type="OrthoDB" id="311720at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035869">
        <property type="term" value="C:ciliary transition zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019184">
        <property type="entry name" value="Uncharacterised_TM-17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13531">
        <property type="entry name" value="GEO07735P1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13531:SF6">
        <property type="entry name" value="TMEM (HUMAN TRANSMEMBRANE PROTEIN) HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09799">
        <property type="entry name" value="Transmemb_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0795444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="189" mass="21834" checksum="B750ACF8D272D4E3" modified="2020-02-26" version="1">MDWKETVTQVSEKVFPGISHKISDNDNIENEVMSNLPLQMALYFNVVFAPVWFVIIVIFLKENFDCYSELYKFLSVTVIVSILIAEVLRLYLGYEGNLRDKIPELAGFWMLSVLLQFPLQSLLLFNPYFNLYVVEVFVQSVMLLLLSAQLFFGYRALKFTALTQAAYFKLVKLRNDSSSAKILCKNKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AEA2</accession>
    <name>A0A5N4AEA2_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF5641 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_12494</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0795655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AEA2"/>
    <dbReference type="InParanoid" id="A0A5N4AEA2"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040676">
        <property type="entry name" value="DUF5641"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008042">
        <property type="entry name" value="Retrotrans_Pao"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF5">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18701">
        <property type="entry name" value="DUF5641"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05380">
        <property type="entry name" value="Peptidase_A17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5641" evidence="1">
        <location>
            <begin position="518"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0795655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="594" mass="67554" checksum="DF27C25C13465F14" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AFC7</accession>
    <name>A0A5N4AFC7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PPYR_10094</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">1611_PpyrPB1</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein heavy chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A5N4AFC7">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AFC7"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097729">
        <property type="term" value="C:9+2 motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005858">
        <property type="term" value="C:axonemal dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001221">
        <property type="entry name" value="Axonemal dynein heavy chain 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.1220:FF:000001">
        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.710:FF:000003">
        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1120:FF:000004">
        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.30:FF:000004">
        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.180.20:FF:000001">
        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002141">
        <property type="entry name" value="Dynein heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.20:FF:000001">
        <property type="entry name" value="dynein heavy chain 2, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.720:FF:000004">
        <property type="entry name" value="Dynein heavy chain 5, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.280:FF:000002">
        <property type="entry name" value="Dynein heavy chain 5, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.490.20:FF:000003">
        <property type="entry name" value="Dynein heavy chain 5, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000044">
        <property type="entry name" value="Dynein heavy chain 5, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.2620:FF:000003">
        <property type="entry name" value="Dynein, axonemal, heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.100:FF:000003">
        <property type="entry name" value="Dynein, axonemal, heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000049">
        <property type="entry name" value="Dynein, axonemal, heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000320">
        <property type="entry name" value="Dynein, axonemal, heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001080">
        <property type="entry name" value="Dynein, axonemal, heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.100">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.20">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.720">
        <property type="entry name" value="Region D6 of dynein motor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035699">
        <property type="entry name" value="AAA_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035706">
        <property type="entry name" value="AAA_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041658">
        <property type="entry name" value="AAA_lid_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042219">
        <property type="entry name" value="AAA_lid_11_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041589">
        <property type="entry name" value="DNAH3_AAA_lid_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042222">
        <property type="entry name" value="Dynein_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043157">
        <property type="entry name" value="Dynein_AAA1S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041466">
        <property type="entry name" value="Dynein_AAA5_ext"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041228">
        <property type="entry name" value="Dynein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043160">
        <property type="entry name" value="Dynein_C_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024743">
        <property type="entry name" value="Dynein_HC_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024317">
        <property type="entry name" value="Dynein_heavy_chain_D4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004273">
        <property type="entry name" value="Dynein_heavy_D6_P-loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013602">
        <property type="entry name" value="Dynein_heavy_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042228">
        <property type="entry name" value="Dynein_linker_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46532:SF4">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46532">
        <property type="entry name" value="MALE FERTILITY FACTOR KL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12774">
        <property type="entry name" value="AAA_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12775">
        <property type="entry name" value="AAA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12780">
        <property type="entry name" value="AAA_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12781">
        <property type="entry name" value="AAA_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17857">
        <property type="entry name" value="AAA_lid_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18198">
        <property type="entry name" value="AAA_lid_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08393">
        <property type="entry name" value="DHC_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17852">
        <property type="entry name" value="Dynein_AAA_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18199">
        <property type="entry name" value="Dynein_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03028">
        <property type="entry name" value="Dynein_heavy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12777">
        <property type="entry name" value="MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0966">Cell projection</keyword>
    <keyword evidence="10" id="KW-0969">Cilium</keyword>
    <keyword evidence="9 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0243">Dynein</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="15">
        <location>
            <begin position="722"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="15">
        <location>
            <begin position="1001"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="15">
        <location>
            <begin position="1328"/>
            <end position="1476"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="1953"/>
            <end position="1980"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="2173"/>
            <end position="2214"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="2538"/>
            <end position="2565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAB0796033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="3371" mass="385985" checksum="562A1F9BA3C46ED3" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-06-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AFQ3</accession>
    <name>A0A5N4AFQ3_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_10204</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AFQ3"/>
    <dbReference type="InParanoid" id="A0A5N4AFQ3"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0796143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="123" mass="14699" checksum="F6EDF4BFABEA16D9" modified="2020-02-26" version="1">MKFRQEKRCGQYSWLSQRKARPILLTRQECEIRKMTCEMSTREKVTVLDLMIKWFNNNPFSPVEMIPEACIGILNDMQSAAILKQVSFKRTSILRQSVARLSLYIRRKRAKFTNKPEVFYIQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AG11</accession>
    <name>A0A5N4AG11_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_10304</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AG11"/>
    <dbReference type="InParanoid" id="A0A5N4AG11"/>
    <dbReference type="OrthoDB" id="2444812at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053076">
        <property type="entry name" value="WW_domain_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46697">
        <property type="entry name" value="FORMIN-BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46697:SF1">
        <property type="entry name" value="FORMIN-BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="2">
        <location>
            <begin position="41"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="2">
        <location>
            <begin position="451"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="515"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="517"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="565"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="583"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0796243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="676" mass="75355" checksum="E3EB1CC0CE5000BA" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AGH7</accession>
    <name>A0A5N4AGH7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Palmitoyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PPYR_10447</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="7"/>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AGH7"/>
    <dbReference type="FunCoup" id="A0A5N4AGH7">
        <property type="interactions" value="5"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AGH7"/>
    <dbReference type="OrthoDB" id="272303at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF452">
        <property type="entry name" value="PALMITOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="50"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="205"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="9">
        <location>
            <begin position="104"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="486"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="486"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="523"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0796386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="548" mass="60307" checksum="B75A35E9443A51C0" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AGX6</accession>
    <name>A0A5N4AGX6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Regulatory protein zeste</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PPYR_10656</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in transvection phenomena (= synapsis-dependent gene expression), where the synaptic pairing of chromosomes carrying genes with which zeste interacts influences the expression of these genes. Zeste binds to DNA and stimulates transcription from a nearby promoter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Self-associates forming complexes of several hundred monomers.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AGX6"/>
    <dbReference type="InParanoid" id="A0A5N4AGX6"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028002">
        <property type="entry name" value="Myb_DNA-bind_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23098">
        <property type="entry name" value="AGAP001331-PA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23098:SF16">
        <property type="entry name" value="REGULATORY PROTEIN ZESTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13873">
        <property type="entry name" value="Myb_DNA-bind_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Myb-like" evidence="7">
        <location>
            <begin position="9"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="85"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0796595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="130" mass="14614" checksum="A5BBBAB2E671DA52" modified="2020-02-26" version="1" fragment="single">MCSNEKKVRAANFTAKEEAILTSLVKQYEHVLECKKTDAVTNQQKTEAWSNVAREFNVVNDSHRSEAVLKKKFENLKKRVKKKLSENKTYSMGTGGGPYKDTPLNDTEEGIKDILGPRAEGFQSQFDGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AHB6</accession>
    <name>A0A5N4AHB6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Sodium-coupled monocarboxylate transporter 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PPYR_10806</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AHB6"/>
    <dbReference type="InParanoid" id="A0A5N4AHB6"/>
    <dbReference type="OrthoDB" id="6132759at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11492">
        <property type="entry name" value="SLC5sbd_NIS-SMVT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051163">
        <property type="entry name" value="Sodium:Solute_Symporter_SSF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00813">
        <property type="entry name" value="sss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985">
        <property type="entry name" value="SODIUM-COUPLED MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985:SF21">
        <property type="entry name" value="SODIUM-DEPENDENT MULTIVITAMIN TRANSPORTER-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="10" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="302"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="390"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="434"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="495"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="521"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="554"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="620"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAB0796745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="690" mass="75979" checksum="CFC34A627D213EDE" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AIT7</accession>
    <name>A0A5N4AIT7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein sleepless</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_08203</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AIT7"/>
    <dbReference type="InParanoid" id="A0A5N4AIT7"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045860">
        <property type="entry name" value="Snake_toxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57302">
        <property type="entry name" value="Snake toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024312560" description="Protein sleepless" evidence="1">
        <location>
            <begin position="21"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0797209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="106" mass="11791" checksum="76DEFED23EDF5FBD" modified="2020-02-26" version="1">MYFKILFITLFVFCVSEVIGLTCMKCESKDDKCWSGNGLKARNCKNPPAGEQAVCMQYQTKVNAVYNAVRECASRKGSASPCDAMKKNHKNCTFCEKDGCNNSPLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AK49</accession>
    <name>A0A5N4AK49_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RNA polymerase II assembly factor Rtp1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_08690</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Tango6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AK49"/>
    <dbReference type="InParanoid" id="A0A5N4AK49"/>
    <dbReference type="OrthoDB" id="39591at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057407">
        <property type="entry name" value="HEAT_TANGO6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019451">
        <property type="entry name" value="Rtp1_C1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019414">
        <property type="entry name" value="Rtp1_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039600">
        <property type="entry name" value="TANGO6/Rtp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20959">
        <property type="entry name" value="TRANSPORT AND GOLGI ORGANIZATION PROTEIN 6 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20959:SF1">
        <property type="entry name" value="TRANSPORT AND GOLGI ORGANIZATION PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23565">
        <property type="entry name" value="ARM_TANGO6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10363">
        <property type="entry name" value="RTP1_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10304">
        <property type="entry name" value="RTP1_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TANGO6 HEAT repeat" evidence="4">
        <location>
            <begin position="259"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase II assembly factor Rtp1 C-terminal" evidence="3">
        <location>
            <begin position="677"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase II assembly factor Rtp1 C-terminal" evidence="2">
        <location>
            <begin position="882"/>
            <end position="913"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0797697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="937" mass="106114" checksum="0230DD6D0EC76714" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AKF1</accession>
    <name>A0A5N4AKF1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxylesterase type B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_08790</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AKF1"/>
    <dbReference type="InParanoid" id="A0A5N4AKF1"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142:SF1">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024456317" description="Carboxylesterase type B domain-containing protein" evidence="5">
        <location>
            <begin position="20"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="6">
        <location>
            <begin position="20"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0797797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="567" mass="63157" checksum="7999C404A934A8D2" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-09-13" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AKF5</accession>
    <name>A0A5N4AKF5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tyr recombinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_08784</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AKF5"/>
    <dbReference type="InParanoid" id="A0A5N4AKF5"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0797791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="103" mass="11914" checksum="2CD7E7629FA1CDE7" modified="2020-02-26" version="1">MLKIKENVDISKFLIITEYMKNNSVGDEAKKSWVLQRKEIQEFMLNAPDINYLLVKVVTGFGIFGACRRQELHDLTVQDVTTEGSVLLVKDIISSLIHRFWEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AKG5</accession>
    <name>A0A5N4AKG5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="6">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PPYR_08787</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AKG5"/>
    <dbReference type="InParanoid" id="A0A5N4AKG5"/>
    <dbReference type="OrthoDB" id="19653at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00312">
        <property type="entry name" value="Esterase_lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142:SF1">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024468989" description="Carboxylic ester hydrolase" evidence="6">
        <location>
            <begin position="19"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="7">
        <location>
            <begin position="28"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0797794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="558" mass="62665" checksum="50337F37BA38F1D9" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AKS4</accession>
    <name>A0A5N4AKS4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pre-mRNA polyadenylation factor Fip1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_08912</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FIP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AKS4"/>
    <dbReference type="InParanoid" id="A0A5N4AKS4"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007854">
        <property type="entry name" value="Fip1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051187">
        <property type="entry name" value="Pre-mRNA_3'-end_processing_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13484">
        <property type="entry name" value="FIP1-LIKE 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13484:SF0">
        <property type="entry name" value="PRE-MRNA 3'-END-PROCESSING FACTOR FIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05182">
        <property type="entry name" value="Fip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pre-mRNA polyadenylation factor Fip1" evidence="6">
        <location>
            <begin position="158"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="303"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="77"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="333"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="379"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="405"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0797919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="440" mass="49615" checksum="E39EA08C81C1546B" modified="2020-02-26" version="1">MADDAESDDQWLYGDGDVDAPPPQAEKQPEVEEKEAVAEQETDNSADQPEEAAPEADPPLDDPPKDKPTENGEAVEEDKQNGEGSDKEDYDEDSDDDVNVVIGDIKTSPTYASLNIKRGGLLTTTTKGDKTLQTPQTGKFTVEEFEHVGLINGIPASEFNLDSLEDKPWRKPGADITDYFNYGFNEDTWRAYCERQKRMRVSESGTGLLPLNAIGMPRGPLPIMNDNSRRMTGSIDVIGGATSRIGVPVSKVEAPKENVIQVMTADRREYSRKPAPFPDMSVPPPTTFEEFHPEYDFNPEPEPFYGGYEPTQDSQWGGNSSWQPQEIKTLTPTAPPGPVMPPAPVPPVNAPMMSNRHPPMPVPSPVKDEMALSRRSKSKEKESMRRERDRSRERDRDRERERSHRRDRSRSRSRRHKSRSRSPSHRSHRKKKSRRHEDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AL17</accession>
    <name>A0A5N4AL17_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PPYR_09002</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AL17"/>
    <dbReference type="InParanoid" id="A0A5N4AL17"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000218">
        <property type="entry name" value="facilitated trehalose transporter Tret1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050549">
        <property type="entry name" value="MFS_Trehalose_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021:SF39">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="315"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="344"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="391"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="460"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="35"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0798009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="533" mass="60067" checksum="45BF23C49C8A4932" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4APA6</accession>
    <name>A0A5N4APA6_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_07040</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4APA6"/>
    <dbReference type="InParanoid" id="A0A5N4APA6"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="15"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="60"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="93"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="138"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="171"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="204"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="237"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0799160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="329" mass="36428" checksum="A4F361BB150352BA" modified="2020-02-26" version="1">MLLDRHAEINATNVRGTTPLHIAVEKGHENLVKLLLEYGADVNAEHCNECGADVNAEDHDGKSVLYVAVERGNEDIVKSLLECRADVKNQDRNGKSVLYVAVERGNEDIVKPLLECGADVNAEDHYECRADVKNQDRNGKSVLYVAVERGNEDIVKPLLECRADVKNQDRNGKSVLYVAVEKRHVNLVKLLLECGADVNAEDHDGKSGLYVAVERGNEDIVKLLLECGADVKNQDRNGKSVLYVAVKKRHVNLVKLLLECGADVNSEDRDEREDVNDYKLLDAAVTEGYLGILEQLLKYGADVDTPLHKATKNKVEGAVNLLLWKLTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4APJ1</accession>
    <name>A0A5N4APJ1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alpha-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_07008</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing (1-&gt;4)-linked alpha-D-glucose residues with release of alpha-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.20"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.20" evidence="3"/>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4APJ1"/>
    <dbReference type="OrthoDB" id="1740265at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004558">
        <property type="term" value="F:alpha-1,4-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11328">
        <property type="entry name" value="AmyAc_maltase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.400.10:FF:000001">
        <property type="entry name" value="Maltase A3, isoform A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.400.10:FF:000002">
        <property type="entry name" value="Sucrose isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="entry name" value="Oligo-1,6-glucosidase, Domain 2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056300">
        <property type="entry name" value="SusG-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357">
        <property type="entry name" value="ALPHA-AMYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF179">
        <property type="entry name" value="NEUTRAL AND BASIC AMINO ACID TRANSPORT PROTEIN RBAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23915">
        <property type="entry name" value="SusG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024326764" description="alpha-glucosidase" evidence="7">
        <location>
            <begin position="19"/>
            <end position="1712"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="8">
        <location>
            <begin position="41"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="8">
        <location>
            <begin position="587"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="8">
        <location>
            <begin position="1142"/>
            <end position="1532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0799128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1712" mass="195779" checksum="7F1F8BC3CAB3C967" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4APT9</accession>
    <name>A0A5N4APT9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Transient receptor ion channel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PPYR_07201</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">1611_PpyrPB1</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cell projection</location>
            <location evidence="13">Rhabdomere membrane</location>
            <topology evidence="13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4APT9"/>
    <dbReference type="InParanoid" id="A0A5N4APT9"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034703">
        <property type="term" value="C:cation channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033583">
        <property type="term" value="C:rhabdomere membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070679">
        <property type="term" value="F:inositol 1,4,5 trisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015279">
        <property type="term" value="F:store-operated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050877">
        <property type="term" value="P:nervous system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051480">
        <property type="term" value="P:regulation of cytosolic calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000221">
        <property type="entry name" value="Transient receptor potential-gamma protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013555">
        <property type="entry name" value="TRP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002153">
        <property type="entry name" value="TRPC_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10117">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10117:SF54">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL-GAMMA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08344">
        <property type="entry name" value="TRP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01420">
        <property type="entry name" value="TRP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="3" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0966">Cell projection</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="ANK" evidence="15">
        <location>
            <begin position="197"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Transient receptor ion channel" evidence="17">
        <location>
            <begin position="232"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00043946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00060916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM01420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAB0799321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="400" mass="46006" checksum="87F158A58BA0F0F9" modified="2020-02-26" version="1">MSTWCTIKESAGEDEEEERRGSVPRGLPGGTDTYIDMPRSDLPSTNTNLLEKPMVDKKVKRHSIHGMMEEENVIRPHQEMAQLSLDEKKFLLAVERGDVASTRRMLQRAQETDYININCVDPLGRSALLMAIDNENLEMVELLIEHKVETKDALLHAISEEFVEAVEVLLDHEETIHKPEEPHSWEALPPDTATFTPDITPLILSAHRDNYEIIKILLDRGATLPMPHDVRCGCDECVTSRMEDSLRHSRSRINAYRALASPSLIALSSKDPILTAFELSWELRRLSFMEHEFKTEYQELRKQCQDFATALLDHTRSSYELEVLLNHDPTGPAFEHGERMHLNRLKLAIKLRQKKVKDKEVLIEISSFVGDDVTSYKMHNFVIRVNRGYYAKLHKNYLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4APU0</accession>
    <name>A0A5N4APU0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">TLC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PPYR_07163</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>sphinganine + octadecanoyl-CoA = N-(octadecanoyl)-sphinganine + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36547"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57394"/>
            <dbReference type="ChEBI" id="CHEBI:57817"/>
            <dbReference type="ChEBI" id="CHEBI:67033"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:36548"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4APU0"/>
    <dbReference type="InParanoid" id="A0A5N4APU0"/>
    <dbReference type="OrthoDB" id="537032at2759"/>
    <dbReference type="UniPathway" id="UPA00222"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050291">
        <property type="term" value="F:sphingosine N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000020">
        <property type="entry name" value="Ceramide synthase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016439">
        <property type="entry name" value="Lag1/Lac1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560:SF0">
        <property type="entry name" value="LD18904P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560">
        <property type="entry name" value="LONGEVITY ASSURANCE FACTOR 1 LAG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005225">
        <property type="entry name" value="LAG1_LAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="12">
        <location>
            <begin position="134"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAB0799283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="353" mass="41738" checksum="50F4C4EBCC2C9827" modified="2020-02-26" version="1">MGAVLQTISDKFWDEDLWLPQNMTWKDLEPGFRDQVWYSNPKHLYLSVPCAFLILTLRYFAERFCLSAIGARVGIRKRKTKAFPNFLLEKTYSICQEMSYVEILGLAKQLDWTERRVERWLRVRNGQSKPSRLKKFCESSWLFCFYLSIFSFGLDAFWNKPWLWDINQCWFEYPRHNIDDEIWWFYIISTSFYLSLFISQFFDVKRKDFWQMFTHHVTTIALLTFCWVLNLHRIGILILLLHICADIFLDAAKVARYAGYQKLCDCIFAMFTVVWIVTRLCIYPFWIIRSTLTMPLTAGPPFPAYFVLNGCLIVLLMLHVFWTYLILKILANCLKAGQTGGDIRSSSSGDSED</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ARZ3</accession>
    <name>A0A5N4ARZ3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial inner membrane protease subunit</fullName>
            <ecNumber evidence="9">3.4.21.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PPYR_07980</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Heterodimer of 2 subunits, IMMPL1 and IMMPL2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the peptidase S26 family. IMP1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="9"/>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0800100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ARZ3"/>
    <dbReference type="FunCoup" id="A0A5N4ARZ3">
        <property type="interactions" value="1160"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4ARZ3"/>
    <dbReference type="OrthoDB" id="308440at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042720">
        <property type="term" value="C:mitochondrial inner membrane peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.109.10">
        <property type="entry name" value="Umud Fragment, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052064">
        <property type="entry name" value="Mito_IMP1_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02227">
        <property type="entry name" value="sigpep_I_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12383:SF16">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12383">
        <property type="entry name" value="PROTEASE FAMILY S26 MITOCHONDRIAL INNER MEMBRANE PROTEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="LexA/Signal peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S26" evidence="10">
        <location>
            <begin position="10"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S26" evidence="10">
        <location>
            <begin position="97"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="39"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR600223-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0800100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="149" mass="16632" checksum="D94E3145F7FD2EDE" modified="2020-02-26" version="1">MKSLTSKLIKTVGYIIQYGCVVHCVSKYLGDIVMCSGRSMEPTVYSDDIVFIEHLSPRFRYISRGDVIIAKCPTNPKQYICKRVVGLPGDKIKTGFTTSQTVPPAHVWLEGDNRENSSDSRAYGPVPLGLICSRAMFVIWPFKHIGSFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ASD0</accession>
    <name>A0A5N4ASD0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PPYR_08008</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">1611_PpyrPB1</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 13">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 13">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the complex I NDUFA10 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0800128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ASD0"/>
    <dbReference type="FunCoup" id="A0A5N4ASD0">
        <property type="interactions" value="1025"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4ASD0"/>
    <dbReference type="OrthoDB" id="17400at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050566">
        <property type="entry name" value="Deoxyribonucleoside_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031314">
        <property type="entry name" value="DNK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015828">
        <property type="entry name" value="NDUFA10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10513">
        <property type="entry name" value="DEOXYNUCLEOSIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10513:SF15">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01712">
        <property type="entry name" value="dNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000543">
        <property type="entry name" value="NADH_UQ_42KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13" id="KW-0249">Electron transport</keyword>
    <keyword evidence="9 13" id="KW-0274">FAD</keyword>
    <keyword evidence="7 13" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="12 13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6 13" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Deoxynucleoside kinase" evidence="14">
        <location>
            <begin position="81"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR000543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAB0800128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="409" mass="47285" checksum="9E7F68AAC7879B31" modified="2020-02-26" version="1">MAGVFRVGLLRVLSINSTNKLLANRSELIVPIRTISGKNARAIAPPTNKPKPWPYKTKGYNIFNSLYDKTTSRFDENSKIIVVEGPIAAGKTKLAKELAAELDMLYLPEANLDMLTTNIYGFNLKKLNDQIPESLRFYDIPDFLLNPRHKMTACFQMRQYVAKFSQYIDALAHVFSTGQGVILDRCVYSDFVFMESMFKLKYISPEARSIYYDARSCSIDELLRPHLIIYLDIPVEKVMANVQKRNYTCEKDSEVINPKYLKSMEDLYKLEYLKKLSTHSELLIYDWSEQGDIEVVVEDIERIDFSRIDEQDAKVKDWVYHLEEEYGCLRNKYADKKNQLMMYLNIPRFDAPELLADGQDFLTYSELVLNSPGNAYETGFNPAMGDNVLFRVRDYPNCETLPLIERSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ATP2</accession>
    <name>A0A5N4ATP2_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">EMI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PPYR_06453</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000004">
        <property type="protein sequence ID" value="KAB0800714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ATP2"/>
    <dbReference type="InParanoid" id="A0A5N4ATP2"/>
    <dbReference type="OrthoDB" id="18487at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005044">
        <property type="term" value="F:scavenger receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.300.10:FF:000002">
        <property type="entry name" value="Multiple epidermal growth factor-like domains 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.300.10:FF:000041">
        <property type="entry name" value="Tyrosine protein kinase receptor tie-1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.300.10">
        <property type="entry name" value="Tie2 ligand-binding domain superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011489">
        <property type="entry name" value="EMI_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042635">
        <property type="entry name" value="MEGF10/SREC1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24043:SF8">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24043">
        <property type="entry name" value="SCAVENGER RECEPTOR CLASS F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00053">
        <property type="entry name" value="EGF_laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00011">
        <property type="entry name" value="EGFLAMININ"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00180">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51041">
        <property type="entry name" value="EMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 5" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024282971" description="EMI domain-containing protein" evidence="7">
        <location>
            <begin position="20"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="407"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="EMI" evidence="9">
        <location>
            <begin position="23"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="136"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="217"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="161"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="238"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0800714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="538" mass="60560" checksum="6A26E5C146717531" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AU22</accession>
    <name>A0A5N4AU22_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4773 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_05226</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000003">
        <property type="protein sequence ID" value="KAB0800872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AU22"/>
    <dbReference type="InParanoid" id="A0A5N4AU22"/>
    <dbReference type="OrthoDB" id="5952164at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031941">
        <property type="entry name" value="DUF4773"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36299">
        <property type="entry name" value="AGAP008005-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36299:SF3">
        <property type="entry name" value="FI03431P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15998">
        <property type="entry name" value="DUF4773"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024399046" description="DUF4773 domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4773" evidence="3">
        <location>
            <begin position="54"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="254"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="472"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="493"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF15998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0800872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="508" mass="55793" checksum="223423DC17F13581" modified="2020-02-26" version="1">MRLSLIFELLLIFVLLAFAASRVIDSKGLPNNRRYSIRKSRRVNHKVRQDVSNYCNCSTKLCNCCRDFNFPVVSVRGPGCATLQYLQGDRLAVSLSFGERVLSNTTISGRKPKPICMQLPGGVSKFCGRVYGITREGEDFKACLGLELRALQDIEASLRVSCFRFGPKGLKVEPAQQLPVVNIQNNKDKDEDDDDDDDDDDDEYDFDDDDDEYDNDVDAVDYTGFSVFDDDFVGDLFGVETESESNKVKKPTPVKKVPVAPTKAPLKSRPSKPLIKKSTVKPLVKATTAKPVTKVTFTPTVTSTGKPVTDKHAQGTPENVAEKLPTVSQQPTVTTAAVLLQNLSDISSAKPASVELTTVSAVSSETSAMEVTTFRAETSSTPPQEDEEDNSTEVVENLIIKDGEDDADDDDEDDDPISAAVEDVLGEGSDSSVKNKTVTAEGNSEKVVKPQHSEDVVDEIVDGMVDTLTGEDSEKVPKKDQISSENKNKREKDDDDEYDDDEEDDDDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AUV0</accession>
    <name>A0A5N4AUV0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PPYR_05499</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">1611_PpyrPB1</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle pole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-13 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000003">
        <property type="protein sequence ID" value="KAB0801145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AUV0"/>
    <dbReference type="FunCoup" id="A0A5N4AUV0">
        <property type="interactions" value="818"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AUV0"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005828">
        <property type="term" value="C:kinetochore microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007019">
        <property type="term" value="P:microtubule depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01367">
        <property type="entry name" value="KISc_KIF2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000012">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054473">
        <property type="entry name" value="KIF2A-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47971:SF8">
        <property type="entry name" value="KINESIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47971">
        <property type="entry name" value="KINESIN-RELATED PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22923">
        <property type="entry name" value="KIF2A-like_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="7" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="9 16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4 15" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="10 14 15" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="17">
        <location>
            <begin position="215"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="643"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="305"/>
            <end position="312"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00061030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAB0801145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="713" mass="80397" checksum="9290BCD50BD3D862" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AW80</accession>
    <name>A0A5N4AW80_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CHK kinase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_03777</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0801591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AW80"/>
    <dbReference type="InParanoid" id="A0A5N4AW80"/>
    <dbReference type="OrthoDB" id="190089at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015897">
        <property type="entry name" value="CHK_kinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004119">
        <property type="entry name" value="EcKL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012">
        <property type="entry name" value="PROTEIN KINASE-LIKE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012:SF30">
        <property type="entry name" value="PROTEIN KINASE-LIKE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02958">
        <property type="entry name" value="EcKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00587">
        <property type="entry name" value="CHK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHK kinase-like" evidence="1">
        <location>
            <begin position="131"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0801591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="415" mass="48140" checksum="6E867E38D4B72394" modified="2020-02-26" version="1">MTQTDVLVTNEVVLNLEELLKKLGTRNYIINISAGTIKGDNFLGVIAKVQVTGETATGEHVIQNFIVKSAPRNENFRMFAPVHAAYEREIYIYSKVLPAFLKLQNDRGIQNPFRSYAKYYDSSVADMNEALIMEDMKEYGFKLHDRHRPLDYNHTLLVLREYGKFHALSFALRDQEPKIFAELAEETQENFFNGMNSTELHNSFQSQSERALNALHPITHKFAHEKFKKFQNNMTDVINAAVKSDLSDPYSVIGHGDCWINNFLFKYDDTNRVPLEMCILDWQLARLGSPALDLGYFLFTCTSKELRDEKYNSLIQEYYKSFRSFLKELGSDADKLFPFDVLQEHLKKYCVYGLCMAVIVLLILISDTEEIPDIHNISSNEHVMDKLNYEPKNIEVYNSRVRDIIFDFIKLGYNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AWQ6</accession>
    <name>A0A5N4AWQ6_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_03889</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0801703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AWQ6"/>
    <dbReference type="InParanoid" id="A0A5N4AWQ6"/>
    <dbReference type="OrthoDB" id="6779810at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0801703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="173" mass="19319" checksum="9D253F5423C5C755" modified="2020-02-26" version="1">MTQVNSAHSRNPPAQLIVPCPVGSNVSHTEDFNVCRPSCSESSHGVLAVVEGGRNVLARYQERRGLSKYEPLNFVCLMGILVRQSYYALAAIFMMILNLLALLQGFLYLTRFIFDKTIDISNADGTATKVYKLTRFIVELLIVVGIQVVVCIFMVFPVCHLIANMYTRVLDTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AXN0</accession>
    <name>A0A5N4AXN0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="24">Ionotropic glutamate receptor C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">PPYR_04106</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">1611_PpyrPB1</strain>
            <tissue evidence="22">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Postsynaptic cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0801920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AXN0"/>
    <dbReference type="FunCoup" id="A0A5N4AXN0">
        <property type="interactions" value="10"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AXN0"/>
    <dbReference type="OrthoDB" id="5984008at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000105">
        <property type="entry name" value="Eye-enriched kainate receptor, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000178">
        <property type="entry name" value="Glutamate receptor subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001508">
        <property type="entry name" value="Iono_Glu_rcpt_met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015683">
        <property type="entry name" value="Ionotropic_Glu_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18966">
        <property type="entry name" value="IONOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00177">
        <property type="entry name" value="NMDARECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00918">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00079">
        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="18" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="9 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0770">Synapse</keyword>
    <keyword evidence="5 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="564"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="640"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="833"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="20">
        <location>
            <begin position="433"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="21">
        <location>
            <begin position="443"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="519"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="524"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="694"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="743"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with the cone snail toxin Con-ikot-ikot" evidence="17">
        <location>
            <position position="699"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with the cone snail toxin Con-ikot-ikot" evidence="17">
        <location>
            <position position="789"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="755"/>
            <end position="813"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="SMART" id="SM00918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAB0801920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="24">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="887" mass="101443" checksum="CF2B4296A061D647" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AZH2</accession>
    <name>A0A5N4AZH2_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Regulatory protein zeste</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_04925</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in transvection phenomena (= synapsis-dependent gene expression), where the synaptic pairing of chromosomes carrying genes with which zeste interacts influences the expression of these genes. Zeste binds to DNA and stimulates transcription from a nearby promoter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Self-associates forming complexes of several hundred monomers.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AZH2"/>
    <dbReference type="InParanoid" id="A0A5N4AZH2"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028002">
        <property type="entry name" value="Myb_DNA-bind_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21411">
        <property type="entry name" value="APONTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21411:SF0">
        <property type="entry name" value="REGULATORY PROTEIN ZESTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13873">
        <property type="entry name" value="Myb_DNA-bind_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Myb/SANT-like DNA-binding" evidence="6">
        <location>
            <begin position="9"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0802739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="134" mass="15550" checksum="F915C8B569D12E0A" modified="2020-02-26" version="1" fragment="single">MHSNKKRVNYTQEEKKLLIHLVDSNKNIIENKDTNAVSNHQKDDVWKIIEQNFNKKCFNVFRDANSLRKQWSNMKQDSRKKAALERQELYKTGGGVAPALSSKNCEANEQLVLDIINKKTVLGLRNEFDSDVMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AZN7</accession>
    <name>A0A5N4AZN7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_04806</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AZN7"/>
    <dbReference type="InParanoid" id="A0A5N4AZN7"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="3">
        <location>
            <begin position="128"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0802620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="237" mass="27758" checksum="7CEE400BEAB2DFE0" modified="2020-02-26" version="1">MDVIDDILLFNEMDIINNIERRPYNTINRFRHVDNFHEWDETDFVRRFRLSKASVLVVLELIQGDIRARTNRNNPIAPLQQLLLTLRFFASGSFYITVSDFGGIHKSTAAQIIKRTVTALSYLITPINNPQGEIETLFNESLIRTRTVVERTFGIWKRRFPILSVGMRCRVELAQNIIVATAVIHNIARQERDAIDDLEDDPLIENVLAPPPRNDNDNHHHRRELLEYFEQLYNHRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B100</accession>
    <name>A0A5N4B100_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_00235</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B100"/>
    <dbReference type="InParanoid" id="A0A5N4B100"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027902">
        <property type="entry name" value="DUF4487"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16071">
        <property type="entry name" value="CHROMOSOME 1 OPEN READING FRAME 112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16071:SF2">
        <property type="entry name" value="FIGNL1-INTERACTING REGULATOR OF RECOMBINATION AND MITOSIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14868">
        <property type="entry name" value="DUF4487"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0803265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="722" mass="82582" checksum="5228BD3B8E7CCA23" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B4A2</accession>
    <name>A0A5N4B4A2_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_01366</name>
        <name evidence="2" type="ORF">PPYR_06211</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000004">
        <property type="protein sequence ID" value="KAB0800471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B4A2"/>
    <dbReference type="InParanoid" id="A0A5N4B4A2"/>
    <dbReference type="OrthoDB" id="10257471at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="19"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0800471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0804396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="256" mass="29415" checksum="B4FDE3BF02FBD152" modified="2020-02-26" version="1">MAPHNNKNFSDKVLINRKSTPVNILPTEILLYIFSFLSNIEILDIARHVCRRWNLLTPKPTLDVKRLRIADSKSQNTRQICDIINSSPKLKDVTISCRSGLSRILKTIGKASKDLRKLKIINGGFCERSKCSAGVNKIVKKCKKLHRIGILANRYYLRRSFKLSVKQKTGRLWSYKSTMDIRNIELNQIPTLLLGLRRYSLEIPIPSSSSVVEEYLRTPYPGYQVAVHRESHLEHFLSLVNNHTSLHETDVLLQVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B4H0</accession>
    <name>A0A5N4B4H0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MADF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_01436</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B4H0"/>
    <dbReference type="InParanoid" id="A0A5N4B4H0"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="102"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0804466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="168" mass="19325" checksum="F2E8C9A5711C9C1E" modified="2020-02-26" version="1">MNKKVFWDKLAKSLREKGHINVDGASLDQKFRYMKNTFKKIKDNSKKTATGRSRVNWKYFDWFEQICASDKAINPPMLVSTIAIDDEAGTSNKENGDNVAKTPSSSRSSTPDSRSGTRLDTFRKRHLILEEARLEELKAIRLEIAESNKINREKLDLLKQHLTCHNNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B4N1</accession>
    <name>A0A5N4B4N1_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PPYR_01541</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome c oxidase VIIa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B4N1"/>
    <dbReference type="FunCoup" id="A0A5N4B4N1">
        <property type="interactions" value="473"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4B4N1"/>
    <dbReference type="OrthoDB" id="5966508at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097250">
        <property type="term" value="P:mitochondrial respirasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002082">
        <property type="term" value="P:regulation of oxidative phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.91.10:FF:000001">
        <property type="entry name" value="Cytochrome c oxidase subunit 7A1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.91.10">
        <property type="entry name" value="Cytochrome c oxidase, subunit VIIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039297">
        <property type="entry name" value="COX7a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036539">
        <property type="entry name" value="Cyt_c_oxidase_su7a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003177">
        <property type="entry name" value="Cytc_oxidase_su7a_met"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10510">
        <property type="entry name" value="CYTOCHROME C OXIDASE POLYPEPTIDE 7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10510:SF11">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 7A, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02238">
        <property type="entry name" value="COX7a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81419">
        <property type="entry name" value="Mitochondrial cytochrome c oxidase subunit VIIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0804571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="89" mass="9965" checksum="5753AF0AC23D417E" modified="2020-02-26" version="1">MNSARKVLPLARICARQLAQDAKHGEVKEVPSKYFARLKEAQKRFQVDDGVPIFLKAGLRDRVLYRATAALTFVGMAMSAQVLYSLAIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B5D2</accession>
    <name>A0A5N4B5D2_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Bardet-Biedl syndrome 2 protein homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PPYR_01724</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B5D2"/>
    <dbReference type="InParanoid" id="A0A5N4B5D2"/>
    <dbReference type="OrthoDB" id="2120021at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034464">
        <property type="term" value="C:BBSome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000967">
        <property type="entry name" value="Bardet-Biedl syndrome 2 protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016616">
        <property type="entry name" value="Bardet-Biedl_syndrome_2_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055381">
        <property type="entry name" value="BBS2_CtH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029333">
        <property type="entry name" value="BBS2_GAE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055380">
        <property type="entry name" value="BBS2_hp_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029429">
        <property type="entry name" value="BBS2_Mid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029430">
        <property type="entry name" value="BBS2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055379">
        <property type="entry name" value="BBS2_pf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32465">
        <property type="entry name" value="BARDET-BIEDL SYNDROME 2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32465:SF0">
        <property type="entry name" value="BARDET-BIEDL SYNDROME 2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23351">
        <property type="entry name" value="BBS2_CtH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14782">
        <property type="entry name" value="BBS2_GAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23353">
        <property type="entry name" value="BBS2_hp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14783">
        <property type="entry name" value="BBS2_Mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14781">
        <property type="entry name" value="BBS2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23350">
        <property type="entry name" value="BBS2_pf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF013684">
        <property type="entry name" value="BBS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4 7" id="KW-0969">Cilium</keyword>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ciliary BBSome complex subunit 2 N-terminal" evidence="8">
        <location>
            <begin position="23"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Ciliary BBSome complex subunit 2 middle region" evidence="10">
        <location>
            <begin position="167"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="BBS2 GAE" evidence="9">
        <location>
            <begin position="390"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="BBS2 platform" evidence="11">
        <location>
            <begin position="486"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="domain" description="BBS2 hairpin" evidence="13">
        <location>
            <begin position="582"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="domain" description="BBS2 C-terminal helix bundle" evidence="12">
        <location>
            <begin position="688"/>
            <end position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR013684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF14782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF23350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF23351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF23353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAB0804754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="713" mass="79711" checksum="D844323DE67F3E33" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B629</accession>
    <name>A0A5N4B629_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TOG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_01978</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0805008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A5N4B629">
        <property type="interactions" value="1230"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4B629"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045180">
        <property type="term" value="C:basal cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005881">
        <property type="term" value="C:cytoplasmic microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040001">
        <property type="term" value="P:establishment of mitotic spindle localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090307">
        <property type="term" value="P:mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024395">
        <property type="entry name" value="CLASP_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21567">
        <property type="entry name" value="CLASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21567:SF9">
        <property type="entry name" value="CLIP-ASSOCIATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12348">
        <property type="entry name" value="CLASP_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TOG" evidence="2">
        <location>
            <begin position="3"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="TOG" evidence="2">
        <location>
            <begin position="252"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="TOG" evidence="2">
        <location>
            <begin position="756"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="domain" description="TOG" evidence="2">
        <location>
            <begin position="1111"/>
            <end position="1345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="483"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="556"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="693"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="980"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="589"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="625"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="724"/>
            <end position="733"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0805008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1357" mass="150998" checksum="CFDE7FBA317D497C" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B663</accession>
    <name>A0A5N4B663_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PPYR_02062</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0805092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B663"/>
    <dbReference type="InParanoid" id="A0A5N4B663"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058353">
        <property type="entry name" value="DUF8040"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF85">
        <property type="entry name" value="GH03217P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26138">
        <property type="entry name" value="DUF8040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF8040" evidence="9">
        <location>
            <begin position="46"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="DDE Tnp4" evidence="8">
        <location>
            <begin position="168"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF26138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0805092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="368" mass="42262" checksum="9780A614C7090764" modified="2020-02-26" version="1">MDLLPVIINLLEGPETSGSSSESSTDSEVEEYARIVRIEGYIERVVVNYSETTFKSHFRMHKLIVYQLASRLENSGFIPVHEHGKMKISSEKAMLMTLWYLGNTESFRQVSDRFDVSLSSAHRVIERVLNCILSLRTEYIKWPTQEETEVISKAFATKFGSQNVIGAIDGCHVRIRRPKNDQDSYINKKGYFSLLIQGTVNSFRQFIDVYCGEPGSLHDARLLRRSSLYSKAENNVNFFGNKYLLGDSAYPSLSWLVPPFKDNGALSNNQKVFNFKHSSTRIIVEHVFGLLKGRFRRLQHLENLNINICVKIMMACCVLHNICESKHDNTVIEPYDISSDVNSEIPLQSDVKNVTRHRREQIFEEMFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-06-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B766</accession>
    <name>A0A5N4B766_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_02415</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0805445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B766"/>
    <dbReference type="InParanoid" id="A0A5N4B766"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0805445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="121" mass="13928" checksum="A1FE5B98AADFCA3F" modified="2020-02-26" version="1">MFLKNTYRTAGLPETFNAIEEILGTTDPYQSEYDASIREETRPISPLLIDDANVEDMAATGKAWVKDIESASRDLVQQSADGDRDNMMFLPRSRQSTIISWRRKHLQRFKNTKITTSNENR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B7H4</accession>
    <name>A0A5N4B7H4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-mannosidase</fullName>
            <ecNumber evidence="3">3.2.1.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PPYR_02496</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides.</text>
            <dbReference type="EC" id="3.2.1.25"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.25" evidence="3"/>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0805526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B7H4"/>
    <dbReference type="InParanoid" id="A0A5N4B7H4"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004567">
        <property type="term" value="F:beta-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000050">
        <property type="entry name" value="Beta-mannosidase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050887">
        <property type="entry name" value="Beta-mannosidase_GH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041625">
        <property type="entry name" value="Beta-mannosidase_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041447">
        <property type="entry name" value="Mannosidase_ig"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43730">
        <property type="entry name" value="BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43730:SF1">
        <property type="entry name" value="BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02836">
        <property type="entry name" value="Glyco_hydro_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17753">
        <property type="entry name" value="Ig_mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17786">
        <property type="entry name" value="Mannosidase_ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="beta-Galactosidase/glucuronidase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Glycoside hydrolase family 2 catalytic" evidence="8">
        <location>
            <begin position="103"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Mannosidase Ig/CBM-like" evidence="10">
        <location>
            <begin position="386"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-mannosidase Ig-fold" evidence="9">
        <location>
            <begin position="489"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0805526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="571" mass="65503" checksum="C821E805F54AE25E" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B7T4</accession>
    <name>A0A5N4B7T4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_02390</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0805420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B7T4"/>
    <dbReference type="InParanoid" id="A0A5N4B7T4"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="3">
        <location>
            <begin position="29"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0805420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="170" mass="19158" checksum="D34F398F23964F19" modified="2020-02-26" version="1">MSDPSADMLKNSAERFKLKWNFDHCMGAIDGKHIQIKAPPKSGSSYFNYKKTFSIVLLAVVDADYRFLMIDVGSKGRFSDGGIFSSSFIGRRLRQGINLPEDEPLYASGSAMPYVVVGDEAFPLLKHLMRPYPGRNLAIEEGIFQLSTIKSSQNFRECVWNFILQVESTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B7U3</accession>
    <name>A0A5N4B7U3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Grh/CP2 DB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PPYR_02588</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the grh/CP2 family. CP2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0805618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B7U3"/>
    <dbReference type="FunCoup" id="A0A5N4B7U3">
        <property type="interactions" value="752"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4B7U3"/>
    <dbReference type="OrthoDB" id="9996779at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007604">
        <property type="entry name" value="CP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057520">
        <property type="entry name" value="GRHL1/CP2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041418">
        <property type="entry name" value="SAM_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040167">
        <property type="entry name" value="TF_CP2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11037:SF21">
        <property type="entry name" value="GEMINI, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11037">
        <property type="entry name" value="TRANSCRIPTION FACTOR CP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04516">
        <property type="entry name" value="CP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25416">
        <property type="entry name" value="GRHL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18016">
        <property type="entry name" value="SAM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51968">
        <property type="entry name" value="GRH_CP2_DB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Grh/CP2 DB" evidence="9">
        <location>
            <begin position="247"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="158"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="64"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="160"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0805618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="692" mass="77270" checksum="B38707DC0CC0EF51" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1JWM0</accession>
    <name>A0A1Y1JWM0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13 19">Inosine-5'-monophosphate dehydrogenase</fullName>
            <shortName evidence="13">IMP dehydrogenase</shortName>
            <shortName evidence="13">IMPD</shortName>
            <shortName evidence="13">IMPDH</shortName>
            <ecNumber evidence="13 19">1.1.1.205</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">PPYR_05313</name>
    </gene>
    <organism evidence="22">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="23 24" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">1611_PpyrPB1</strain>
            <tissue evidence="23">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">1611_PpyrPB1</strain>
            <tissue evidence="23">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13 19">
            <text>IMP + NAD(+) + H2O = XMP + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="1.1.1.205"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="13">Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.</text>
    </comment>
    <comment type="pathway">
        <text evidence="13 19">Purine metabolism; XMP biosynthesis via de novo pathway; XMP from IMP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13 18">Belongs to the IMPDH/GMPR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.205" evidence="13 19"/>
    <dbReference type="EMBL" id="GEZM01098853">
        <property type="protein sequence ID" value="JAV53714.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01098850">
        <property type="protein sequence ID" value="JAV53717.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01098849">
        <property type="protein sequence ID" value="JAV53718.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000003">
        <property type="protein sequence ID" value="KAB0800959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <sequence length="529" mass="57373" checksum="0DBA16CCEB43068F" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1JWT5</accession>
    <name>A0A1Y1JWT5_PHOPY</name>
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        <recommendedName>
            <fullName evidence="9 11">Adenylosuccinate synthetase</fullName>
            <shortName evidence="9">AMPSase</shortName>
            <shortName evidence="9">AdSS</shortName>
            <ecNumber evidence="9 11">6.3.4.4</ecNumber>
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        <alternativeName>
            <fullName evidence="9">IMP--aspartate ligase</fullName>
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    </protein>
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        <name evidence="14" type="ORF">PPYR_03775</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.</text>
    </comment>
    <comment type="function">
        <text evidence="11">Plays an important role in the de novo pathway of purine nucleotide biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9 11">
            <text>IMP + L-aspartate + GTP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+)</text>
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            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="6.3.4.4"/>
        </reaction>
    </comment>
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        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9 11">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1 9">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 11">Belongs to the adenylosuccinate synthetase family.</text>
    </comment>
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        <property type="molecule type" value="Transcribed_RNA"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="project" value="TreeGrafter"/>
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                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
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                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
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                <person name="Shigenobu S."/>
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        <property type="entry name" value="Initiation_fac_eIF4g_MI"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034:SF3">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR CWC22 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51366">
        <property type="entry name" value="MI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="480"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="439"/>
            <end position="468"/>
        </location>
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        <location>
            <begin position="679"/>
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        </location>
    </feature>
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        <location>
            <begin position="18"/>
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        </location>
    </feature>
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        <location>
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        <location>
            <begin position="70"/>
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        </location>
    </feature>
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        <location>
            <begin position="447"/>
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        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="688"/>
            <end position="707"/>
        </location>
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    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="713"/>
            <end position="729"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="JAV55474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0797936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="729" mass="83442" checksum="30212E298E5379B0" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1K6M4</accession>
    <name>A0A1Y1K6M4_PHOPY</name>
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        <recommendedName>
            <fullName evidence="2">small monomeric GTPase</fullName>
            <ecNumber evidence="2">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PPYR_09472</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="2"/>
    <dbReference type="EMBL" id="GEZM01093742">
        <property type="protein sequence ID" value="JAV56151.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1K6M4"/>
    <dbReference type="FunCoup" id="A0A1Y1K6M4">
        <property type="interactions" value="1620"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1K6M4"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Rab18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000430">
        <property type="entry name" value="Probable Ras-related protein Rab-18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="JAV56151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAB0798479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="206" mass="23331" checksum="C7B3C354AA6E8D97" modified="2017-08-30" version="1">MEDDILTTLKILIIGESGVGKSSLLLRFTDDNFDPEQTLTIGVDFKTKRLNIDGNNVKLAIWDTAGQERFRTLTPSYYRDAQGAILVYDVCNYATFSKLETWLNELETYSTKRNIVKMVVANKIDMENREVSRDEGLHFAKKYKTLFIEASAKTRDGVQSAFEELVQQIIQTPDLWDSYSLGNNVSLGNKDHPAHTSQCSGYCNLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1KE62</accession>
    <name>A0A1Y1KE62_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Suppressor of forked domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PPYR_08463</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the crooked-neck family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01086114">
        <property type="protein sequence ID" value="JAV59772.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000006">
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    </dbReference>
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        <location>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF23220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23231"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF23233"/>
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    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="JAV59772.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAB0797470.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
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    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
    <sequence length="849" mass="99383" checksum="D730CAB998C0F5B9" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
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        <recommendedName>
            <fullName evidence="10">TM2 domain-containing protein</fullName>
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        <name evidence="12" type="ORF">PPYR_04920</name>
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    <organism evidence="11">
        <name type="scientific">Photinus pyralis</name>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
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            <taxon>Lampyrinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TM2 family.</text>
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    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
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    </dbReference>
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        <property type="entry name" value="TM2D1-3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21016">
        <property type="entry name" value="BETA-AMYLOID BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21016:SF4">
        <property type="entry name" value="TM2 DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05154">
        <property type="entry name" value="TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
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    <feature type="chain" id="PRO_5033289526" description="TM2 domain-containing protein" evidence="9">
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        <location>
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        </location>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008284"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="JAV59952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAB0802734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="176" mass="19702" checksum="7299C55E7EB14C10" modified="2017-08-30" version="1">MYFLIVLYHLLITGINCEVPGENASFDPLGPLVQCSFLSWEFIDCEEPVDHKGNKTAKDELGYGCIKFGGMWYDDVERTKVPCTVLDKIECYGNKTFLKEGVACIKYSQQFFATTLLYSILLGFLGMDRFCLGQTGTAVGKLLTLGGLGIWWIVDIVLLITNNLTPEDGSNWNIYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1KH66</accession>
    <name>A0A1Y1KH66_PHOPY</name>
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        <recommendedName>
            <fullName evidence="2">VPS9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="4" type="ORF">PPYR_13638</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Photinus pyralis</name>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
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            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
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            <taxon>Lampyridae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
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                <person name="Al-Wathiqui N."/>
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                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01087335">
        <property type="protein sequence ID" value="JAV58756.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0794018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1KH66"/>
    <dbReference type="InParanoid" id="A0A1Y1KH66"/>
    <dbReference type="OrthoDB" id="411646at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:plasma membrane"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030133">
        <property type="term" value="C:transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097422">
        <property type="term" value="C:tubular endosome"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:early endosome to late endosome transport"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048812">
        <property type="term" value="P:neuron projection morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
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    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
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        <property type="entry name" value="UPF0507/Ank_repeat_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003123">
        <property type="entry name" value="VPS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037191">
        <property type="entry name" value="VPS9_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24170">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24170:SF2">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02204">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109993">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ANK_REP_REGION"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51205">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VPS9" evidence="2">
        <location>
            <begin position="222"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="415"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="448"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="481"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="520"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="676"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="744"/>
            <end position="776"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="JAV58756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0794018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="813" mass="91446" checksum="F2ADD9FB6E1E3F5C" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1KHA2</accession>
    <name>A0A1Y1KHA2_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PPYR_09286</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 14">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GEZM01084015">
        <property type="protein sequence ID" value="JAV60847.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01084010">
        <property type="protein sequence ID" value="JAV60852.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
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        <property type="protein sequence ID" value="KAB0798293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-EC"/>
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    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="receptor-type tyrosine-protein phosphatase zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000013">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase zeta isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF540">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE 99A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PTPc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="253"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="10">
        <location>
            <begin position="38"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="10">
        <location>
            <begin position="133"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="8">
        <location>
            <begin position="337"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="9">
        <location>
            <begin position="517"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="8">
        <location>
            <begin position="635"/>
            <end position="887"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="JAV60852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAB0798293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="931" mass="106536" checksum="C3A18792A511F2D3" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1KJ01</accession>
    <name>A0A1Y1KJ01_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Chitin-binding type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_06136</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
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            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GEZM01075687">
        <property type="protein sequence ID" value="JAV64015.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0795780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1KWG0"/>
    <dbReference type="InParanoid" id="A0A1Y1KWG0"/>
    <dbReference type="OrthoDB" id="10033548at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000900">
        <property type="term" value="F:mRNA regulatory element binding translation repressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008135">
        <property type="term" value="F:translation factor activity, RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000766">
        <property type="term" value="P:negative regulation of cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19757">
        <property type="entry name" value="Bbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12724">
        <property type="entry name" value="RRM1_CPEB2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12726">
        <property type="entry name" value="RRM2_CPEB2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000008">
        <property type="entry name" value="Cytoplasmic polyadenylation element-binding 2 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.640.40:FF:000001">
        <property type="entry name" value="Cytoplasmic polyadenylation element-binding 2 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000009">
        <property type="entry name" value="cytoplasmic polyadenylation element-binding protein 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.640.40">
        <property type="entry name" value="Cytoplasmic polyadenylation element-binding protein, ZZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032296">
        <property type="entry name" value="CEBP_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038446">
        <property type="entry name" value="CEBP_ZZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034819">
        <property type="entry name" value="CPEB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12566">
        <property type="entry name" value="CYTOPLASMIC POLYADENYLATION ELEMENT BINDING PROTEIN CPEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12566:SF12">
        <property type="entry name" value="TRANSLATIONAL REGULATOR ORB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16366">
        <property type="entry name" value="CEBP_ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16367">
        <property type="entry name" value="RRM_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="114"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="222"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="86"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="92"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="JAV64015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0795780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="371" mass="41371" checksum="7A18F631AC2C935E" modified="2017-08-30" version="1">MFRAYGTSPLVDASATHEPRTNPAHEGVTNWRLRTYGEKILEGFINCNTNAFQSLSQLHGKTSYFPGLDDQAGPVLLEEPGHLVDNTLGAQPLSSPSRSSPHSQGSEGGERFSRKVFVGGLPPDIDEDEITASFRRFGPLVVDWPHKAESKSYFPPKGYAFLLFQDENSVQSLIDACITDEDKLYLCVSSPTIKDKPVQIRPWRLSDADFVLDASMPLDPRKTVFVGGVPRPLKAVELAMIMDRLYGGVCYAGIDTDPELKYPKGAGRVAFSNQQSYIAAISARFVQLQHGDIDKRVEVKPYVLDDQMCDECQGQRCGGKFAPFFCANVTCLQYYCEHCWATIHSRPGREFHKPLVKEGADRPRAVPFRWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1KYI3</accession>
    <name>A0A1Y1KYI3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PPYR_05516</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DAMOX/DASOX family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01070018">
        <property type="protein sequence ID" value="JAV66463.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000003">
        <property type="protein sequence ID" value="KAB0801162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1KYI3"/>
    <dbReference type="FunCoup" id="A0A1Y1KYI3">
        <property type="interactions" value="155"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1KYI3"/>
    <dbReference type="OrthoDB" id="2015447at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003884">
        <property type="term" value="F:D-amino-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019478">
        <property type="term" value="P:D-amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006181">
        <property type="entry name" value="D-amino_acid_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023209">
        <property type="entry name" value="DAO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530">
        <property type="entry name" value="D-AMINO ACID OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530:SF11">
        <property type="entry name" value="D-ASPARTATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000189">
        <property type="entry name" value="D-aa_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00677">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="8">
        <location>
            <begin position="4"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="42"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="47"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="305"/>
            <end position="310"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000189-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="JAV66463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0801162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="335" mass="36401" checksum="B51C3D2619DD6024" modified="2017-08-30" version="1">MFNIAIIGGGVVGLSTANVIQDSLKSLAKITIYSENLSPNTTSDVAAGLWGPYLFFDTNPDQVLAWAKLTHKQFLNLWKNGSASEAGISLQSVKSVSGAPHTPFTTHINFGEHPMTPAEVDEMGQLLNQQFQSGVTFVTLACEPMKYLPYLLQRFLRNGGILKHQKVNSLDQLSHYDLIVNCCGLGASSLIGDTQMKPVRGQIMRVKAPWQFTSALVGSVYIIPNLSFTILGGTSQVDDRDTTVRDADTAKIIKGCKDLMPAIENAEVIEHKVGIRPGRVKVRLERETMSMNGKQMPVIHNYGHGGCGITLSYGTAVSATELVKEALNIPPMSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1KZR8</accession>
    <name>A0A1Y1KZR8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Cytochrome b-c1 complex subunit 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PPYR_02473</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
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    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 11 subunits. The complex is composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein UQCRFS1, 2 core protein subunits UQCRC1/QCR1 and UQCRC2/QCR2, and 6 low-molecular weight protein subunits UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and subunit 9, the cleavage product of Rieske protein UQCRFS1. The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and cytochrome c oxidase (complex IV, CIV), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein, 2 core protein subunits, and additional low-molecular weight protein subunits. The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with cytochrome c oxidase (complex IV, CIV).</text>
    </comment>
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            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the UQCRB/QCR7 family.</text>
    </comment>
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        <property type="entry name" value="QCR7_sf"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12022">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX 14 KD PROTEIN"/>
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    </dbReference>
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        <source>
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    </evidence>
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        <source>
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</entry>
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
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            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
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        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
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                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="5">1611_PpyrPB1</strain>
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        </source>
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    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
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        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
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        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
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            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="9">Binds 1 [2Fe-2S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I 24 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01063062">
        <property type="protein sequence ID" value="JAV69341.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1L963"/>
    <dbReference type="FunCoup" id="A0A1Y1L963">
        <property type="interactions" value="1326"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1L963"/>
    <dbReference type="OrthoDB" id="10254187at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902494">
        <property type="term" value="C:catalytic complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098796">
        <property type="term" value="C:membrane protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03064">
        <property type="entry name" value="TRX_Fd_NuoE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000022">
        <property type="entry name" value="NADH dehydrogenase flavoprotein 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1590:FF:000001">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1590">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002023">
        <property type="entry name" value="NuoE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042128">
        <property type="entry name" value="NuoE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041921">
        <property type="entry name" value="NuoE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01958">
        <property type="entry name" value="nuoE_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005722">
        <property type="entry name" value="PRK07539.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005725">
        <property type="entry name" value="PRK07539.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10371:SF3">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10371">
        <property type="entry name" value="NADH DEHYDROGENASE UBIQUINONE FLAVOPROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01257">
        <property type="entry name" value="2Fe-2S_thioredx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000216">
        <property type="entry name" value="NADH_DH_24kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01099">
        <property type="entry name" value="COMPLEX1_24K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="5 9" id="KW-0408">Iron</keyword>
    <keyword evidence="6 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-1278">Translocase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="201"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000216-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="JAV69341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAB0796230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="241" mass="27204" checksum="2862EC2C8AB66C5E" modified="2017-08-30" version="1">MISLKNIARLWQKGLVRNLQTSSALQHDALFVHRDTAEDNPDIKFEFSPENLKRVDAILAIYPEGHKRAAMIPLLDLAQRQYGWLPLSAMHKVAEILDLPRMRVYEVATFYTMFIRKPIGKYHLQVCTTTPCWLRGSDDILSTIKNHLKINVGDTTCDKLFSLSEVECLGACVNAPMVQINDDYYEDLTCDDMIEILDELKDGKRPRAGPRNGRYASEPLGQPTSLTSEPPGPGFGIRSDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LG78</accession>
    <name>A0A1Y1LG78_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Inositol oxygenase</fullName>
            <ecNumber evidence="4 14">1.13.99.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 14">Myo-inositol oxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PPYR_02984</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">1611_PpyrPB1</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">1611_PpyrPB1</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 14">
            <text>myo-inositol + O2 = D-glucuronate + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23696"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:58720"/>
            <dbReference type="EC" id="1.13.99.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13 14">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="13 14">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Polyol metabolism; myo-inositol degradation into D-glucuronate; D-glucuronate from myo-inositol: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the myo-inositol oxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.13.99.1" evidence="4 14"/>
    <dbReference type="EMBL" id="GEZM01058133">
        <property type="protein sequence ID" value="JAV71881.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1LG78"/>
    <dbReference type="FunCoup" id="A0A1Y1LG78">
        <property type="interactions" value="82"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1LG78"/>
    <dbReference type="OrthoDB" id="5151075at2759"/>
    <dbReference type="UniPathway" id="UPA00111">
        <property type="reaction ID" value="UER00527"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050113">
        <property type="term" value="F:inositol oxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019310">
        <property type="term" value="P:inositol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007828">
        <property type="entry name" value="Inositol_oxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12588:SF0">
        <property type="entry name" value="INOSITOL OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12588">
        <property type="entry name" value="MYOINOSITOL OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05153">
        <property type="entry name" value="MIOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="7 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="12">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="93"/>
            <end position="95"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="149"/>
            <end position="150"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="228"/>
            <end position="229"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR607828-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR607828-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="JAV71881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAB0791184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="293" mass="34727" checksum="045F707E3F7997F8" modified="2017-08-30" version="1">MRILSTAAPIALIDPSELLRPEPSFADKSLSKFRDYSINEDDPIKERVRKTYEEMHTFQTVEFVKNQHKKWRRFDHFKAPIRDALEKLNDLVDESDPDVDVPNIVHAFQTAERIREDYPDMDWFHLTGLIHDLGKVMAFYDEPQWAVVGDTFVVGCEWSEDIVYRDHSFAKNVDGSNPKYNTKYGIYEANCGIDNALMSWGHDEYLYWVLKHNNAALPQEALAMIRYHSFYPWHSSNNYSHLENQHDRDMKKWVQLFNTYDLYTKSSKVPDIEKLWPYYESLIEKYIPGIVEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LLF7</accession>
    <name>A0A1Y1LLF7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">S1 motif domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_05224</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRP4 family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01052494">
        <property type="protein sequence ID" value="JAV74482.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000003">
        <property type="protein sequence ID" value="KAB0800870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1LLF7"/>
    <dbReference type="FunCoup" id="A0A1Y1LLF7">
        <property type="interactions" value="1905"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1LLF7"/>
    <dbReference type="OrthoDB" id="1650at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071034">
        <property type="term" value="P:CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22525">
        <property type="entry name" value="KH-I_Rrp4_eukar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05789">
        <property type="entry name" value="S1_Rrp4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000038">
        <property type="entry name" value="Exosome complex component RRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025721">
        <property type="entry name" value="Exosome_cplx_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026699">
        <property type="entry name" value="Exosome_RNA_bind1/RRP40/RRP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048565">
        <property type="entry name" value="S1_RRP4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321:SF4">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321">
        <property type="entry name" value="PNAS-3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14382">
        <property type="entry name" value="ECR1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15985">
        <property type="entry name" value="KH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21266">
        <property type="entry name" value="S1_RRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110324">
        <property type="entry name" value="Ribosomal L27 protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0271">Exosome</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="S1 motif" evidence="7">
        <location>
            <begin position="82"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="JAV74482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0800870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="296" mass="33444" checksum="5DC1BAC121F10332" modified="2017-08-30" version="1">MLQEIHIRLAETRDNTPLAINQRVPKIFTPGEIISEQQEFMRGHGTYEEDIYLKASVAGIKEQVNKLISIRPLKSRYNGEIGDVVVGRITEVQQKRWKVDTNSRLDSLLLLSSVNLPGGELRRRSAEDEHMMRQYLQEGDLISAEVQNVFSDGSLSLHTRSFKYGKLSQGVMLKVFPSLIKRSKTHFHDLPIGASVILGNNGFVWISPTMVNQEDNVGGFTQNLEEVVPRGTRETIGRLRNCILALAQSNVMLFDTSILYAYEESLKYNVAELLLPEAMVDVAILTQHKLNLSEYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LRB3</accession>
    <name>A0A1Y1LRB3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nucleosome assembly protein 1-like 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_07221</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the nucleosome assembly protein (NAP) family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01052548">
        <property type="protein sequence ID" value="JAV74445.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1LRB3"/>
    <dbReference type="FunCoup" id="A0A1Y1LRB3">
        <property type="interactions" value="2118"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1LRB3"/>
    <dbReference type="OrthoDB" id="27325at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1500:FF:000001">
        <property type="entry name" value="Nucleosome assembly protein 1-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1120.90:FF:000001">
        <property type="entry name" value="Nucleosome assembly protein 1-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.90">
        <property type="entry name" value="Nucleosome assembly protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037231">
        <property type="entry name" value="NAP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002164">
        <property type="entry name" value="NAP_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11875">
        <property type="entry name" value="TESTIS-SPECIFIC Y-ENCODED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00956">
        <property type="entry name" value="NAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143113">
        <property type="entry name" value="NAP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="112"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="331"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
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        <location>
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        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00009947"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU003876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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            <dbReference type="EMBL" id="JAV74445.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAB0799341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="371" mass="43248" checksum="D1BAFFF51F6448D6" modified="2017-08-30" version="1">MATQPEHVGDCPDEMESVDDEETAHDVAHRMLKYPDVLAALQSHHNSEMLANLPPAVKRRIKSLKKLQLEATHIEAKFFEEVHAIECKYHKLYLPLYQKRSTIINGDYEPNDDECQWVSDEEEELSKDMKEKSKLEDKKEEPVKEELPSKGIPDFWLTIFRNVSILSEMVQEHDEPILKHLKDIRVNFMNEPMGFVLEFHFEPNEYFTNTVLTKEYDMKCVPDEDDPFGFEGPEIYKCRGCLINWNKGKNVTLKTVKKKQKHKSRGVVRTVMKTVQNDSFFNFFTPATVPEDIPDGEVDEETRNLLTSDFEIGHYIRERIIPRAILYFTGEGIEEEEEYEEEEDDEEEEEEDSDGGKDCGNVNSDQNCKPQ</sequence>
</entry>
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        <name evidence="9" type="ORF">PPYR_12794</name>
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        <name type="scientific">Photinus pyralis</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
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            <taxon>Coleoptera</taxon>
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            <taxon>Elateroidea</taxon>
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    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
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                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
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                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
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            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
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        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
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            <dbReference type="PubMed" id="30324905"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">1611_PpyrPB1</strain>
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    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </reference>
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        <text evidence="1 7">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
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    </dbReference>
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    </dbReference>
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</entry>
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    <reference evidence="1" key="1">
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            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
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            <dbReference type="PubMed" id="30324905"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <tissue evidence="2">Whole body</tissue>
        </source>
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        <property type="term" value="F:odorant binding"/>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAB0790044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="183" mass="21220" checksum="A3D63BBDA120799C" modified="2017-08-30" version="1">MYTSVYSLILFTLLFNDQIKKGLLDVTHLTLEDAKCFPYGFNFDYEEQEFVHLVVIPYLEIKSIEELSHLNLIPIDNPRYNEFLSCMWKNKRFQSYNGAINYEAIEKALSASMGRDVGDTGPGILLSKMEGSRIVMICRDLGGYTHGQRVVLVRNCILQELKKFVQKQNGRRYSNNLGTYYHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1M209</accession>
    <name>A0A1Y1M209_PHOPY</name>
    <protein>
        <submittedName>
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    <organism evidence="3">
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        <name type="common">Common eastern firefly</name>
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            <taxon>Insecta</taxon>
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            <taxon>Endopterygota</taxon>
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            <taxon>Polyphaga</taxon>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
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                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
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        <property type="entry name" value="RING FINGER AND SPRY DOMAIN-CONTAINING PROTEIN 1"/>
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    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
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    </dbReference>
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        <location>
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        <location>
            <begin position="485"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
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        <source>
            <dbReference type="PROSITE" id="PS50188"/>
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    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="JAV82214.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAB0801852.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
    <sequence length="531" mass="59548" checksum="EB9640ADC2E28463" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1MAJ6</accession>
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            <fullName evidence="6">Large ribosomal subunit protein uL29m</fullName>
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        <name evidence="8" type="ORF">PPYR_08321</name>
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        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="term" value="P:mitochondrial translation"/>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00035289"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="JAV80906.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAB0797327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="246" mass="29426" checksum="0CD41E6296E9C898" modified="2017-08-30" version="1">MFLNSICNHFRTSHRYVNGTLKERIRHVSTSPVMSGLMEFFDDEKNWGSSEVKTGRSWTKDDLRIKSNTDLHKLWYVLVKEKNMLLSMEHEHNEQVRLFPSPERLDKVLDSMENLEEVVRERNRAYYELETTELGEQPHKTVTGPFGLPVDYHETEHSIPKEVNAQWQKEQNVKCRPEDVKAFLLKYKEREYLENRRRQRRDFNHVIGLLNRFPKMDMEALKEQYPDVDIEKAKASRKYKPPVVFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1MCU1</accession>
    <name>A0A1Y1MCU1_PHOPY</name>
    <protein>
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            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 7</fullName>
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        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PPYR_15730</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
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            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
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            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG7 family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01036283">
        <property type="protein sequence ID" value="JAV82828.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01002117">
        <property type="protein sequence ID" value="KAB0789984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1MCU1"/>
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        <property type="interactions" value="802"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="245173at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019335">
        <property type="entry name" value="COG7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21443">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21443:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10191">
        <property type="entry name" value="COG7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
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    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="63"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
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                <person name="Sander Lower S.E."/>
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                <person name="Sander Lower S.E."/>
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                <person name="Debat H.J."/>
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                <person name="Day J.C."/>
                <person name="Suvorov A."/>
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                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="239" mass="26938" checksum="F80876F085DD25B1" modified="2017-08-30" version="1">MQKLVGLLFFIGLACAATDFMQHLPGLPNIDDVANLEGAAKEKCIQHGGEDAFKTLKKLAVELQSFIMQNFEPVTIRQELEEARKTGSMDDVFKKYCDLRPDFFKHSHKVNDAIESCLSEAERPVFKLGVNVSESLMEFVCEKDGDRVAMFIAENGFECIKSQQDNLQKCSSDIVNKHKPTNFNAIPALAKITKEQCTEYQSFQKCVVDTLEGCTEKTPANIVDAFFKFVYKLIQCKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1MT75</accession>
    <name>A0A1Y1MT75_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">uS12 prolyl 3-hydroxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PPYR_11942</name>
        <name evidence="12" type="ORF">PPYR_13716</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>[ribosomal protein uS12]-L-proline + 2-oxoglutarate + O2 = [ribosomal protein uS12]-(3S)-3-hydroxy-L-proline + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:54156"/>
            <dbReference type="Rhea" id="RHEA-COMP:13816"/>
            <dbReference type="Rhea" id="RHEA-COMP:13818"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:50342"/>
            <dbReference type="ChEBI" id="CHEBI:85428"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TPA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01023518">
        <property type="protein sequence ID" value="JAV88338.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0794096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0795103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1MT75"/>
    <dbReference type="FunCoup" id="A0A1Y1MT75">
        <property type="interactions" value="1615"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1MT75"/>
    <dbReference type="OrthoDB" id="430522at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031543">
        <property type="term" value="F:peptidyl-proline dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006449">
        <property type="term" value="P:regulation of translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019601">
        <property type="entry name" value="Oxoglutarate/Fe-dep_Oase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039558">
        <property type="entry name" value="TPA1/OFD1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051842">
        <property type="entry name" value="uS12_prolyl_hydroxylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12117">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12117:SF0">
        <property type="entry name" value="PROLYL 3-HYDROXYLASE OGFOD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13661">
        <property type="entry name" value="2OG-FeII_Oxy_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10637">
        <property type="entry name" value="Ofd1_CTDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0847">Vitamin C</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="10">
        <location>
            <begin position="161"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="JAV88338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAB0794096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAB0795103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="506" mass="58969" checksum="8B9B4CCCB3CDEBFF" modified="2017-08-30" version="1">MDIPGNSSEHPDSEDDCVIISNLLTKSTIRGYHYPKLTKEQYVTPEPPTKLMKPSLAIRNDLTTTAFLDFFHQNYVNSEYAVNDNVEIVKEPFKVCVVHNFLDDEAVLLKIQDEFNEIEWNKRSLDLYEFFQSKDLKDVHSYYVSCMYEFLKNDVKDWIQNLTGMEFVNISATCSLYTHTDYLLVHDDLQGSRAIAFVLYFSGPASWKTESGGALQLFEMDFVGEPSDVVRSIYPRNNQFVFFPVSTNSYHQVEEIVNREDCRMSINGWFHTVNPLCEKPPQPISNTTVFTEEFINPKLVDLDLESWIHPDYLDSETAESIQKQMEEESELSLHDFIKTDQWQQVVADLYSPDLEWDHAGPPNRRSCDVLCKQNLPDNIRQFIDLFLSHEMFVLLKNYTDLDFKHVRYELQRWGPQCYSLLSDYDWSNKSELDLVLYLGLPDTVPMVGGKTMYIAVEDRIEEALVTLDPQENCLNLVFRDTARITKYVSKCNRIKTFFMLICSYSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1NBV0</accession>
    <name>A0A1Y1NBV0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pentacotripeptide-repeat region of PRORP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_01790</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01007696">
        <property type="protein sequence ID" value="JAV94988.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1NBV0"/>
    <dbReference type="InParanoid" id="A0A1Y1NBV0"/>
    <dbReference type="OrthoDB" id="6073372at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034629">
        <property type="entry name" value="PTCD2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14700">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14700:SF0">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="JAV94988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0804820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="399" mass="45894" checksum="824111E73B7F16F9" modified="2017-08-30" version="1">MALLRQTLQPLVNYAFHTQTAKIIFRKPGVRQLYAAATLGLDNFLSQRDRVKAQLANVAPKFKEKMTEYTADDSKNMVFTEDLKNMLHLAETNDDVTLVIKMMKRFNQQNKQLRFGNYVFGPVIMRLFYFLNKHEEAFQCFKSTELNGLFDQMMSYQILLDLLYENQRYNDILEAFEIIKSRQIEGVKFARNVVVLMFAACYKLNTQQSLEIALKLWSEINSIGHFPMRRAVTFCSGLAINQGKPEIGLEILSGAKNANYTTIRNLKVVALVDLGRIDDALAVLKSILQEDGARMGPIHTFNMDVIGKLKNAVKERNNADLSLEFDRLEKYFKDHGHISNTLLNDQLCTEIAPPQSVRNNANEFSRQQYRTPYDDSRRNPNYRRRTNGGPARPGLSEMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1NEC9</accession>
    <name>A0A1Y1NEC9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PPYR_09277</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01009504">
        <property type="protein sequence ID" value="JAV94546.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:GTPase activator activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="TBC1 domain family, member 20"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
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    </dbReference>
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        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
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        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
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        <property type="entry name" value="TBC20/Gyp8-like"/>
    </dbReference>
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        <property type="entry name" value="RE60063P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20913">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 20/GTPASE"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="386"/>
            <end position="403"/>
        </location>
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        <location>
            <begin position="87"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="JAV94546.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAB0798284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="420" mass="49339" checksum="97B2152C0B9EF0D7" modified="2017-08-30" version="1">MESHSEIINGDDESSSMLNDDSNKLDTNSSEFISSEENEDTRSELKFDAVLESAEEKSKRLQIEEVLKSGDSVLETWRRLALSRYGLVNDDLRRQVWPLLLNVDPDPSEKAPLLSELSQHSEYSQVVLDVNRSLKRFPPGIPYRQRLALQDQLTVLILRVIMKYPHLRYYQGYHDVAITFLLVVGETVAFRIMERLSTDHLRECMEPTMEKTSYTLTYIYPILQREDLDLYEFMDRAMVGTMFALPWYLTWFGHSLNQYRDVVRLYDYFLASPPLMPLYVTASLVIDRRQEVFDVGCDMASIHCLLSQIPDNLDFESILERASDLYKKYPPSKLEKDVKNRVQKELEQRRKDEARIRRRLDKNKATWVKMRHYLPNWLLLHYRNKYGLLFATATLLVGLYAYLRATETGFSLFKQGPWNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1NG99</accession>
    <name>A0A1Y1NG99_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Vacuolar protein sorting-associated protein 16 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_03944</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Late endosome membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Lysosome membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="3">Cytoplasmic, peripheral membrane protein associated with late endosomes/lysosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the VPS16 family.</text>
    </comment>
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        <property type="protein sequence ID" value="JAV96565.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="JAV96566.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01003786">
        <property type="protein sequence ID" value="JAV96567.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="JAV96568.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0801758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1NG99"/>
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    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:CORVET complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.780">
        <property type="entry name" value="Vps16, C-terminal region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016534">
        <property type="entry name" value="VPS16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006925">
        <property type="entry name" value="Vps16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038132">
        <property type="entry name" value="Vps16_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006926">
        <property type="entry name" value="Vps16_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12811">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING VPS16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12811:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 16 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Vps16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="VPS16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0967">Endosome</keyword>
    <keyword evidence="3" id="KW-0458">Lysosome</keyword>
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    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vps16 N-terminal" evidence="5">
        <location>
            <begin position="7"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="Vps16 C-terminal" evidence="4">
        <location>
            <begin position="521"/>
            <end position="823"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR007949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="JAV96568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0801758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="841" mass="96229" checksum="3AD3ECD80AA454AD" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1NI38</accession>
    <name>A0A1Y1NI38_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_00911</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01001937">
        <property type="protein sequence ID" value="JAV97449.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1NI38"/>
    <dbReference type="InParanoid" id="A0A1Y1NI38"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23992">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.20">
        <property type="entry name" value="Pheromone/general odorant binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006170">
        <property type="entry name" value="PBP/GOBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036728">
        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01395">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036029919" evidence="1">
        <location>
            <begin position="18"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="JAV97449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0803941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="140" mass="15811" checksum="A4283A429739FD1F" modified="2017-08-30" version="1">MKWPLCIALIFVLTVHSKPINHGALGPEIECLKQYMDIIDDIMKEVHSITPPENEAVGEYVVCYLKKRQILEDNGEINADNIYKYWSEVYYTTISSDSEEKQLRDAAAECAKLTAPNLPILGLKIKNCLLEGARKLPFVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-06-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N3ZZ83</accession>
    <name>A0A5N3ZZ83_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_15262</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01001405">
        <property type="protein sequence ID" value="KAB0790370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N3ZZ83"/>
    <dbReference type="InParanoid" id="A0A5N3ZZ83"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0790370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="52" mass="6108" checksum="F77B9E5E6BA19A61" modified="2020-02-26" version="1" fragment="single">ERNKVHHHIVSVPPFLWMDFPSMYVITLRNGTSGSLTSILEQLVYHDPDWSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N3ZZB2</accession>
    <name>A0A5N3ZZB2_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_15234</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01001379">
        <property type="protein sequence ID" value="KAB0790402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N3ZZB2"/>
    <dbReference type="InParanoid" id="A0A5N3ZZB2"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006986">
        <property type="term" value="P:response to unfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14809">
        <property type="entry name" value="bZIP_AUREO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039165">
        <property type="entry name" value="CREBRF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21552">
        <property type="entry name" value="ADULT RETINA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21552:SF2">
        <property type="entry name" value="CREB3 REGULATORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="2">
        <location>
            <begin position="462"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="197"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0790402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="566" mass="62757" checksum="9395BE92395DD2EC" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A058</accession>
    <name>A0A5N4A058_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA-binding protein SATB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Special AT-rich sequence-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PPYR_14858</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">1611_PpyrPB1</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the CUT homeobox family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000887">
        <property type="protein sequence ID" value="KAB0790701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A058"/>
    <dbReference type="FunCoup" id="A0A5N4A058">
        <property type="interactions" value="213"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A058"/>
    <dbReference type="OrthoDB" id="10257567at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048468">
        <property type="term" value="P:cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048699">
        <property type="term" value="P:generation of neurons"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.40:FF:000004">
        <property type="entry name" value="Cut-like homeobox 1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000298">
        <property type="entry name" value="Homeobox protein cut-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.40:FF:000027">
        <property type="entry name" value="Homeobox protein cut-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003350">
        <property type="entry name" value="CUT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
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        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
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    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14043">
        <property type="entry name" value="CCAAT DISPLACEMENT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14043:SF2">
        <property type="entry name" value="HOMEOBOX PROTEIN CUT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02376">
        <property type="entry name" value="CUT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CUT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51042">
        <property type="entry name" value="CUT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 10 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 10 11" id="KW-0371">Homeobox</keyword>
    <keyword evidence="9 10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 12" id="KW-0805">Transcription regulation</keyword>
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        <location>
            <begin position="348"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="CUT" evidence="15">
        <location>
            <begin position="559"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="14">
        <location>
            <begin position="687"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="10">
        <location>
            <begin position="689"/>
            <end position="748"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="92"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="222"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="524"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="648"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="844"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
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            <begin position="932"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
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            <begin position="94"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
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            <begin position="235"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
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            <begin position="275"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="539"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="859"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="932"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="969"/>
            <end position="1011"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAB0790701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1011" mass="112977" checksum="8427502D4AC2A18C" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A1S9</accession>
    <name>A0A5N4A1S9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GAR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PPYR_03039</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="InParanoid" id="A0A5N4A1S9"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:microtubule plus-end"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001725">
        <property type="term" value="C:stress fiber"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008093">
        <property type="term" value="F:cytoskeletal anchor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051764">
        <property type="term" value="P:actin crosslink formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001578">
        <property type="term" value="P:microtubule bundle formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904825">
        <property type="term" value="P:protein localization to microtubule plus-end"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031110">
        <property type="term" value="P:regulation of microtubule polymerization or depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Gas2-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036534">
        <property type="entry name" value="GAR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46756:SF18">
        <property type="entry name" value="GAS2-LIKE PROTEIN PICKLED EGGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46756">
        <property type="entry name" value="TRANSGELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02187">
        <property type="entry name" value="GAS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00243">
        <property type="entry name" value="GAS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143575">
        <property type="entry name" value="GAS2 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51460">
        <property type="entry name" value="GAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAR" evidence="5">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="119"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
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            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="330"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="422"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="130"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="156"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="205"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="284"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="330"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0791239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="453" mass="50675" checksum="285AA2C206C352B7" modified="2020-02-26" version="1">MTNVRDLVEKCTCPTQFPMIRVSEGKYRIGDTKVLIFVRILRSHVMVRVGGGWDTLAHYLDKHDPCRCRSQHRTTQGARLINKPGAADLQGAHVYYDRSPPRVPQHNLNGYATNAVREYLGPPTNSLNRSRSRSPSHLSRRSVSPNLPRKTLAPPLSSNRSRSPTPNFVSTHSTKLSNAKTQSPKHGKPHQISALQIDPKLTMKSEATLQVSESSTDHSDNASEVSDEGYRSLGLIQTEKNKNRISLYSQNSVEDVDESEHQDILDYEDDTNDAGLRRTQFSHIYKESPEKGKLTKQRSLETPRSRASSKERAPPEMIPKLIPKCNVNTWSGRQKSARPSLTLDTFSPPPLKRNSPTRRSATTIYAPRRSSLSAATSPTKGRLKDELLEAVKNNNDDISIAEQVKKLLKKYSSLTVLDTNNKIADPVTTRSPRKDSKPDNMISRIPAPISHKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A2G8</accession>
    <name>A0A5N4A2G8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LsmAD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_03296</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ataxin-2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A2G8"/>
    <dbReference type="FunCoup" id="A0A5N4A2G8">
        <property type="interactions" value="1516"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A2G8"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034063">
        <property type="term" value="P:stress granule assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045117">
        <property type="entry name" value="ATXN2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009604">
        <property type="entry name" value="LsmAD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009818">
        <property type="entry name" value="PAM2_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025852">
        <property type="entry name" value="SM_dom_ATX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12854">
        <property type="entry name" value="ATAXIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12854:SF7">
        <property type="entry name" value="ATAXIN-2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06741">
        <property type="entry name" value="LsmAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07145">
        <property type="entry name" value="PAM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14438">
        <property type="entry name" value="SM-ATX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01272">
        <property type="entry name" value="LsmAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LsmAD" evidence="3">
        <location>
            <begin position="177"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="125"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="248"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="358"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="627"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="289"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="306"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="417"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="460"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="475"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="500"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="518"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="646"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="706"/>
            <end position="715"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0791496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="715" mass="78570" checksum="6801EE4897700C4E" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A3U9</accession>
    <name>A0A5N4A3U9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_13966</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A3U9"/>
    <dbReference type="InParanoid" id="A0A5N4A3U9"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0792005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="131" mass="15070" checksum="0F24970A807986B6" modified="2020-02-26" version="1">MISYWNFWDTGAKVGGRKINCVRFADNMVILVESVHKLNGMPKAEGGSIINKKAIKGNEDVLNGGRKKNKRSWISVMEEGYQNPRMILEIREKRKLLNTTPKRRSNWIGHVLRKMLEGSLEEEKEWQLSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A3Z2</accession>
    <name>A0A5N4A3Z2_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="12">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PPYR_13950</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">1611_PpyrPB1</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PPP phosphatase family. PP-2B subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="12"/>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0791989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A3Z2"/>
    <dbReference type="InParanoid" id="A0A5N4A3Z2"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033192">
        <property type="term" value="F:calmodulin-dependent protein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097720">
        <property type="term" value="P:calcineurin-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030431">
        <property type="term" value="P:sleep"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07416">
        <property type="entry name" value="MPP_PP2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000002">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041751">
        <property type="entry name" value="MPP_PP2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043360">
        <property type="entry name" value="PP2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45673">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024290999" description="Serine/threonine-protein phosphatase" evidence="15">
        <location>
            <begin position="19"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="16">
        <location>
            <begin position="534"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="854"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="858"/>
            <end position="868"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAB0791989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="889" mass="101315" checksum="455E9B6AD81D6CFC" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A4B9</accession>
    <name>A0A5N4A4B9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PPYR_14110</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">1611_PpyrPB1</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Microsome membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 15">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A4B9"/>
    <dbReference type="FunCoup" id="A0A5N4A4B9">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A4B9"/>
    <dbReference type="OrthoDB" id="1055148at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008395">
        <property type="term" value="F:steroid hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006805">
        <property type="term" value="P:xenobiotic metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000238">
        <property type="entry name" value="Cytochrome P450 2A6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050182">
        <property type="entry name" value="Cytochrome_P450_fam2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300:SF376">
        <property type="entry name" value="CYTOCHROME P450 15A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300">
        <property type="entry name" value="CYTOCHROME P450 508A4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 14 15" id="KW-0349">Heme</keyword>
    <keyword evidence="11 14 15" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0492">Microsome</keyword>
    <keyword evidence="12 15" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="10 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024439793" description="Cytochrome P450" evidence="16">
        <location>
            <begin position="20"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="14">
        <location>
            <position position="431"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAB0792151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="19">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="484" mass="54948" checksum="176DB5681F9B9352" modified="2020-02-26" version="1">MWSVIILILVLVLLAYLDTRKPRYFPPGPAWFPILGCAWELRRLQKETGSLSGATQALARRYGPVVGARVGRERVVFVCGSKAIHELLSRDELNGRPDSDVTRSRTGGKRRGLLFTDSEFLQEQKRFVLRHINEASFRKEVMRESIEEEVRSIIDGVTRAIEKNPVVDMYSFFRIHVLNAFCFLISGQTSQQHELSDLEAITASFSENVPLAGPIFGLFPFLRHICPDYCGYNLHVEMHEKILEFFHKKVEVLRDAASTRGFIHAYLDKLNLGQSGDSFSEEQLLAVCLDLLIAGYDSTCNTLKFAFLYLILHPDIQKKAQEEIDTVLQGRLPTVEDRSYLPYVESIVLESIRMFVGRSHYVPRRATKDTQLSGYFIRKNTTIIGNIRGILMDEAAGWHNPEDFDPGRFMRDGSLKISDNFSPFGSGKRRCVGEVFARENMFVVVAGLLQAFNFETVPGNPATVEAVENFTPTVKPYKTYVTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A4H4</accession>
    <name>A0A5N4A4H4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_14184</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A4H4"/>
    <dbReference type="InParanoid" id="A0A5N4A4H4"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005154">
        <property type="term" value="F:epidermal growth factor receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048018">
        <property type="term" value="F:receptor ligand activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007173">
        <property type="term" value="P:epidermal growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043403">
        <property type="entry name" value="Gurken/Spitz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12332">
        <property type="entry name" value="KEREN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12332:SF1">
        <property type="entry name" value="KEREN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="108"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="224"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="142"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0792225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="265" mass="29462" checksum="567C9B4FA8AD7801" modified="2020-02-26" version="1">MFSRSISLAHVMWAAWGWGRRPPGILTPLLFVLRCLSQALATGFHRFLARFSGRRRLLETINHKSPPPWTLLVLLVSTLLSIAEACSSRTTPKPRPPAPTARPNITFHTYECPPAYAAWYCLNGATCFTVKIGDSLVYNCECTEGYMGPRCEYKDLDGSYMPSQRGFMLETASIAGGAAIAVLLVVILCVVIYVNYWRRNKSTRTSADCIDGCASAHRPNQPTFGTRWRTTTATSSDQRDETKQGRVELHQVTTLLTSPNQASRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A4R7</accession>
    <name>A0A5N4A4R7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GRIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PPYR_14266</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A4R7"/>
    <dbReference type="FunCoup" id="A0A5N4A4R7">
        <property type="interactions" value="202"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A4R7"/>
    <dbReference type="OrthoDB" id="425925at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000237">
        <property type="entry name" value="GRIP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18921">
        <property type="entry name" value="MYOSIN HEAVY CHAIN - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18921:SF2">
        <property type="entry name" value="THYROID RECEPTOR-INTERACTING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01465">
        <property type="entry name" value="GRIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50913">
        <property type="entry name" value="GRIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GRIP" evidence="5">
        <location>
            <begin position="910"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="70"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="356"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="665"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="869"/>
            <end position="903"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0792307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1060" mass="121795" checksum="FEEC0F3171EEAB49" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A5E2</accession>
    <name>A0A5N4A5E2_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Odorant receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PPYR_14481</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cell membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A5E2"/>
    <dbReference type="InParanoid" id="A0A5N4A5E2"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="350"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU351113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0792522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="375" mass="43354" checksum="AE3885FCE0A5FA9E" modified="2020-02-26" version="1">MTGHPSDTYFSVAGKYAKRTGLFLKENVSIREKMFSYGLLSLVYFNFSLICSILYEGWNESNGINDVIPTLGYLNVIPRTAIIRFHKLKLVKTLRMLDEVNICNSDRRRQFKAVIETYMKWVFQITCSLALSVVVVGTITWYFTRLTPLPFGIMPKWALNYSFTSCLIIQLITFPFIAHEYVMIDCLKVGILIQLQMHFKNLRLDILNLLSCCTEDGVDSWEYLQNEVKKVNIYWDTLKDICTKIEDVFNLCVFSTVINYSLYLCCTYLGMSHIPLYGAEFWLIIFYLFASSFMFVADCWFTQRVITESDQVASSCYDVDFVGTDLKFQKALMLMIGKAKRPVRFTIGKFAPFCIVTLVVIAKVSFSYVTFLENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A693</accession>
    <name>A0A5N4A693_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">15-hydroxyprostaglandin dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_14790</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A693"/>
    <dbReference type="FunCoup" id="A0A5N4A693">
        <property type="interactions" value="119"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A693"/>
    <dbReference type="OrthoDB" id="417891at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229:SF8">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024365101" description="15-hydroxyprostaglandin dehydrogenase" evidence="4">
        <location>
            <begin position="19"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0792831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="296" mass="31735" checksum="7259037BB8BE09D6" modified="2020-02-26" version="1">MVQTVIIVALTILACASSHSKQRYECNGKIALVTGGTRGIGLSITSELLKNGVKGVTMVGVNADKGKEAVAALSEKFGQGRVISLIADVSNEKQFEEAFKASIVHWGGLDIVINNAGVVNENNPVPLTNVNAIGVMHGTLLGMRHMSVAKGGRGGVVINLSSIYGIDHLFASPVYSATKAYVLGLGRAFGHQTYYDHNKVRILTLCPGLTKTDLLSEVPFKNGISNEFNPDLKEVAYGSVEKSFLQTPDNLGRAVIVMLKQAASGSVWVAEDEQPPYEVEIPERKAMKKQKASHFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A774</accession>
    <name>A0A5N4A774_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protein smoothened</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PPYR_12804</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">1611_PpyrPB1</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the G-protein coupled receptor Fz/Smo family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A774"/>
    <dbReference type="FunCoup" id="A0A5N4A774">
        <property type="interactions" value="489"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A774"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005113">
        <property type="term" value="F:patched binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007417">
        <property type="term" value="P:central nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071679">
        <property type="term" value="P:commissural neuron axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007389">
        <property type="term" value="P:pattern specification process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007224">
        <property type="term" value="P:smoothened signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009888">
        <property type="term" value="P:tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd15030">
        <property type="entry name" value="7tmF_SMO_homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2000.10">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015526">
        <property type="entry name" value="Frizzled/SFRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000539">
        <property type="entry name" value="Frizzled/Smoothened_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020067">
        <property type="entry name" value="Frizzled_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036790">
        <property type="entry name" value="Frizzled_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035683">
        <property type="entry name" value="SMO_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11309">
        <property type="entry name" value="FRIZZLED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11309:SF35">
        <property type="entry name" value="PROTEIN SMOOTHENED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01534">
        <property type="entry name" value="Frizzled"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01392">
        <property type="entry name" value="Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00489">
        <property type="entry name" value="FRIZZLED"/>
    </dbReference>
    <dbReference type="SMART" id="SM00063">
        <property type="entry name" value="FRI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01330">
        <property type="entry name" value="Frizzled"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63501">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50038">
        <property type="entry name" value="FZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024373035" description="Protein smoothened" evidence="15">
        <location>
            <begin position="19"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="290"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="340"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="385"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="427"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="474"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="543"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="domain" description="FZ" evidence="16">
        <location>
            <begin position="89"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="17">
        <location>
            <begin position="254"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="699"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="851"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="884"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="699"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="851"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="897"/>
            <end position="910"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00035037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAB0793184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="910" mass="103411" checksum="A83D5925C0CDE61C" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A7G5</accession>
    <name>A0A5N4A7G5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_12880</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A7G5"/>
    <dbReference type="InParanoid" id="A0A5N4A7G5"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF12">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="490"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="749"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="832"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="782"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="803"/>
            <end position="812"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0793260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="858" mass="97833" checksum="F74FCD6B9B95D779" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A7P5</accession>
    <name>A0A5N4A7P5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PPYR_12960</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A7P5"/>
    <dbReference type="FunCoup" id="A0A5N4A7P5">
        <property type="interactions" value="25"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A7P5"/>
    <dbReference type="OrthoDB" id="9451254at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048619">
        <property type="term" value="P:embryonic hindgut morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016348">
        <property type="term" value="P:imaginal disc-derived leg joint morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007366">
        <property type="term" value="P:periodic partitioning by pair rule gene"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000958">
        <property type="entry name" value="Odd skipped"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000254">
        <property type="entry name" value="Odd-skipped related transciption factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000318">
        <property type="entry name" value="Odd-skipped-related transciption factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000311">
        <property type="entry name" value="protein odd-skipped-related 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000148">
        <property type="entry name" value="zinc finger protein Gfi-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050717">
        <property type="entry name" value="C2H2-ZF_Transcription_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14196">
        <property type="entry name" value="ODD-SKIPPED - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14196:SF11">
        <property type="entry name" value="PROTEIN SISTER OF ODD AND BOWEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0562">Pair-rule protein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="210"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="238"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="266"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="294"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="322"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAB0793340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="377" mass="41500" checksum="37883BC2562DD909" modified="2020-02-26" version="1">MQASTEANLICDKQDLPKTQDVNATLNLAMLQENFLQRSIQNVALSLQNAMMNSLQQAALLPPNSAAAAALNLQALESYITLQRLTSVSAANTGNGNNRIDILKLATSSAKISEESVSEDSVHNTSLTEDVDLAEEVEEDLALLDNDDALNFPIASSPVDTSYPSMIMNSLYNNQSASGVVTTSQAATTTTTTTPAGVRPKSSSRPKKQFICKFCSRQFTKSYNLLIHERTHTDERPYSCDICGKAFRRQDHLRDHRYIHSKEKPFKCAECGKGFCQSRTLAVHKILHMEESPHKCPVCSRSFNQRSNLKTHLLTHTDIKPYNCSACGKVFRRNCDLRRHSLTHNLGTAGNGSVMATSPLLGNQNFSIDSLISTTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AAY9</accession>
    <name>A0A5N4AAY9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">SAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PPYR_11322</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0794483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AAY9"/>
    <dbReference type="FunCoup" id="A0A5N4AAY9">
        <property type="interactions" value="73"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AAY9"/>
    <dbReference type="OrthoDB" id="8188861at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20101">
        <property type="entry name" value="MBT_L3MBTL1-like_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20102">
        <property type="entry name" value="MBT_L3MBTL1-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20103">
        <property type="entry name" value="MBT_L3MBTL1-like_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000007">
        <property type="entry name" value="Lethal(3)malignant brain tumor-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004092">
        <property type="entry name" value="Mbt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050548">
        <property type="entry name" value="PcG_chromatin_remod_factors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002515">
        <property type="entry name" value="Znf_C2H2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036060">
        <property type="entry name" value="Znf_C2H2C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12247:SF131">
        <property type="entry name" value="LD05287P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12247">
        <property type="entry name" value="POLYCOMB GROUP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02820">
        <property type="entry name" value="MBT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01530">
        <property type="entry name" value="zf-C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00561">
        <property type="entry name" value="MBT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103637">
        <property type="entry name" value="CCHHC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51079">
        <property type="entry name" value="MBT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51802">
        <property type="entry name" value="ZF_CCHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="MBT" evidence="10">
        <location>
            <begin position="609"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="repeat" description="MBT" evidence="10">
        <location>
            <begin position="714"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="repeat" description="MBT" evidence="10">
        <location>
            <begin position="823"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="12">
        <location>
            <begin position="1078"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="289"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="425"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="574"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="967"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="290"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="305"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="342"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="967"/>
            <end position="979"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAB0794483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1145" mass="130099" checksum="3B6DF0EDEA9E69E8" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ADF3</accession>
    <name>A0A5N4ADF3_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PPYR_12107</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0795268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A5N4ADF3">
        <property type="interactions" value="1616"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4ADF3"/>
    <dbReference type="OrthoDB" id="67716at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059141">
        <property type="entry name" value="Beta-prop_Nup120_160"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021717">
        <property type="entry name" value="Nucleoporin_Nup160"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056547">
        <property type="entry name" value="NUP160_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056536">
        <property type="entry name" value="TPR_NUP160_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056535">
        <property type="entry name" value="TPR_NUP160_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21286">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21286:SF0">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11715">
        <property type="entry name" value="Beta-prop_Nup120_160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23345">
        <property type="entry name" value="NUP160_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23354">
        <property type="entry name" value="TPR_NUP160_120_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23347">
        <property type="entry name" value="TPR_Nup160_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup120/160 beta-propeller" evidence="4">
        <location>
            <begin position="54"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="NUP160 helical" evidence="5">
        <location>
            <begin position="556"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="domain" description="NUP160 middle TPR" evidence="7">
        <location>
            <begin position="811"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="domain" description="NUP160 C-terminal TPR" evidence="6">
        <location>
            <begin position="1122"/>
            <end position="1374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF11715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF23354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0795268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1388" mass="157896" checksum="9329316F0DB53737" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ADW1</accession>
    <name>A0A5N4ADW1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">LRRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_12352</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0795513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ADW1"/>
    <dbReference type="InParanoid" id="A0A5N4ADW1"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050541">
        <property type="entry name" value="LRR_TM_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369">
        <property type="entry name" value="ANTIGEN BSP, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369:SF210">
        <property type="entry name" value="CHAOPTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0795513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="332" mass="37955" checksum="73B3FF4F28F37918" modified="2020-02-26" version="1">MSMECEVPTFNNNIIQVNFIHNRTISGCISPDTIQFNGEISDIQVTDQDIQDLNYGAVQRVSSKFSILFQNTGIEIIREGAFLDLLKLYKIIFWNNKLFWISENAFQDLPSLTEVRVAMNNITDVSPRAFNNLPNLTEVSLAENKLENFDQSWFYKTPVLQVLNLKKNRLRKIPRAAFINLPSIKILRLQRNKIEFIHKDAFIGLRNLITLFMANNKLKSFDFNLYTSSKSVRVLIPNNNITYISDEVLNAIGPQLSELDITENPLQCACLDKIIQWSGAFNINVPQWIFPKVGGPVCIVPKTKPSECLARSDDDFPEGIWDSFALEFARVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AF58</accession>
    <name>A0A5N4AF58_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Saccharopine dehydrogenase NADP binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_10026</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the saccharopine dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0795965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AF58"/>
    <dbReference type="InParanoid" id="A0A5N4AF58"/>
    <dbReference type="OrthoDB" id="10268090at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009247">
        <property type="term" value="P:glycolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000178">
        <property type="entry name" value="Saccharopine dehydrogenase-like oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051276">
        <property type="entry name" value="Saccharopine_DH-like_oxidrdct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12286">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12286:SF5">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="273"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="363"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="Saccharopine dehydrogenase NADP binding" evidence="3">
        <location>
            <begin position="7"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0795965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="426" mass="47594" checksum="B4000AB3B975436F" modified="2020-02-26" version="1">MDNKLDIVVFGATGFTGKHTIPYLHKLCEEDGRQLKWGIAGRSEEKLKKVLDEYAQKLGADSLNSTPIIIADVEDELSILEMAKKAKMVLNCCGPYQLYGEVVVKCCVMTGTHYVDVTGETHFQDIMLSRYGHTAEERGVYIVHGCGMDSMGNEMPLNFLTKSFQGVLNSVEVFMMSKFGNQTTTGSGLNFGTWSSIVHSLSDFRSVWAAKRAISLPKMSPSCPLRFPFSKNASIGIPNKRILPFPSPDTDVINRSQQYFYKNGQRPIQVRHYYLLESWTSILKLLFMGLITIIFSQFSCGKKLLLKYPKVFSGGYVDHESPSEEMIENSTIDMYFYGKGWSDKKDIEFNQRPNKSILGKIDIVNPGYGFTCLAVVLSAIIILTEPSKLPKKGGVYTPAVAFFHTSMVEALQKNGVPLEILSVNDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AF70</accession>
    <name>A0A5N4AF70_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_10041</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0795980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AF70"/>
    <dbReference type="InParanoid" id="A0A5N4AF70"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="3">
        <location>
            <begin position="99"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0795980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="180" mass="20387" checksum="09AEEBFA65F97730" modified="2020-02-26" version="1">MDVIDVHVYPSSDEDDGEIKQDNFVVWDEHEFYQRFRISKRLANIVLELVQNDIVTRTRWNHAVQPVTALLLTLRFLASGSMLIVAGDFVGVHKLSVRGEQAEMYRNRKGFFSYNVQAICDARLKIRDVVARWPGSVHDATIFSQSAIKNRLQNNPGALADSVLVADSGYANTNYCITKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AG14</accession>
    <name>A0A5N4AG14_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serine protease HTRA2, mitochondrial</fullName>
            <ecNumber evidence="5">3.4.21.108</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">High temperature requirement protein A2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PPYR_10351</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">1611_PpyrPB1</strain>
            <tissue evidence="20">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Can antagonize antiapoptotic activity of th/Diap1 by directly inducing the degradation of th/Diap1.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of non-polar aliphatic amino-acids at the P1 position, with a preference for Val, Ile and Met. At the P2 and P3 positions, Arg is selected most strongly with a secondary preference for other hydrophilic residues.</text>
            <dbReference type="EC" id="3.4.21.108"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
            <topology evidence="3">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase S1C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.108" evidence="5"/>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AG14"/>
    <dbReference type="FunCoup" id="A0A5N4AG14">
        <property type="interactions" value="1100"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AG14"/>
    <dbReference type="OrthoDB" id="4217619at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043065">
        <property type="term" value="P:positive regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.120:FF:000004">
        <property type="entry name" value="Serine protease HTRA2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22939">
        <property type="entry name" value="SERINE PROTEASE FAMILY S1C HTRA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22939:SF129">
        <property type="entry name" value="SERINE PROTEASE HTRA2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13365">
        <property type="entry name" value="Trypsin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0720">Serine protease</keyword>
    <keyword evidence="12" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="16" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="PDZ" evidence="19">
        <location>
            <begin position="285"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00029644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00035606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAB0796290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="401" mass="43799" checksum="CEDF9E1527F63EA9" modified="2020-02-26" version="1">MSFLLKTVTNTLMRSNFRSVLNKNIKCTYLLFDTTFTKNENQKSTNNSLMYGVAIASTWIAYKLFKSGNIVPTVEASTDRRNQYNFIADVVETCSEAVVYIEIKDARRVDFFTGKPMTISNGSGFIIKSDGLIVTNAHVVTNKPQAKVEVRLSNGTVYHGMVEDIDLRSDLATVRIQAKNLPIMKLGDSGLLRPGEFVVAIGSPLSLSNTVTSGVISSTQRGSAELGLRDKNMVYIQTDAAITFGNSGGPLVNLNGEAIGVNSMKVTSGISFAIPINYVKDFLKTVRSNQTSQTENVKRKYMGITMLTLTDQIIYELHQRDQFIPPSITHGVLVWKVIVGSPAHSGGLQPGDIVTDINSEPIKSANDVYAILAKEKSAKLNMTVVRSGKSLNISITPEDVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-06-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AGJ1</accession>
    <name>A0A5N4AGJ1_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_10389</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AGJ1"/>
    <dbReference type="InParanoid" id="A0A5N4AGJ1"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0796328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="91" mass="10342" checksum="8A633C6AB11D2623" modified="2020-02-26" version="1">MHPILCGVLLAALMQNYSRKFHLGLLREFENQKMGSSTRSSVLRRFGIRVPAVLPRFYDEPGDGLTLGDLGWSFRVLNLCKIPDFPVSNYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AH45</accession>
    <name>A0A5N4AH45_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Laminin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PPYR_10599</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AH45"/>
    <dbReference type="FunCoup" id="A0A5N4AH45">
        <property type="interactions" value="88"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AH45"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005604">
        <property type="term" value="C:basement membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016358">
        <property type="term" value="P:dendrite development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008045">
        <property type="term" value="P:motor neuron axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009888">
        <property type="term" value="P:tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000098">
        <property type="entry name" value="Netrin-A, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050440">
        <property type="entry name" value="Laminin/Netrin_ECM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008211">
        <property type="entry name" value="Laminin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056863">
        <property type="entry name" value="LMN_ATRN_NET-like_EGF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10574:SF365">
        <property type="entry name" value="NETRIN-A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10574">
        <property type="entry name" value="NETRIN/LAMININ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24973">
        <property type="entry name" value="EGF_LMN_ATRN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00055">
        <property type="entry name" value="Laminin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00180">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00136">
        <property type="entry name" value="LamNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01248">
        <property type="entry name" value="EGF_LAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50027">
        <property type="entry name" value="EGF_LAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51117">
        <property type="entry name" value="LAMININ_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 6" id="KW-0424">Laminin EGF-like domain</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024422747" description="Laminin N-terminal domain-containing protein" evidence="7">
        <location>
            <begin position="18"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin N-terminal" evidence="9">
        <location>
            <begin position="41"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="8">
        <location>
            <begin position="347"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="349"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="368"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0796538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="418" mass="46560" checksum="08C31B7A3538BBA2" modified="2020-02-26" version="1">MKLQYIIWLSAVSCTLAISDNFLKMFGAQQTPADPCYDEDRPRRCIPDFVNAAFGRSIAASSTCGLKGTVQYCDVLDVGGAPQCNICDDQNPRKRFPSVFLTDINNPNNVTCWRSEPLQPPTSVHAPPDNITLILSLGKKYELTYVSLQFCPHTPKPDSIAIYKSMDYGKTWQPFQFYSSQCRRVYGRPNRATITKANEQEARCTDAHRYTGGEGLGLGHQSRIAFSTLEGRPSALDFDNSPVLQDWVTATDIKVVFNRLHMPVEDPSDDLDILIDEHEFKQQQEDDDEDDPTKGPSVQLVNEMQVVEADDTKVSVSVDMGGNGIMNVYNRVTHQYAVSDFAVGGRCKCNGHASKCITGRDGQLTCECKHNTAGRDCERCKPFHFDRPWSRATARDANECKGKIVVALNTPVNKPLNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AHN6</accession>
    <name>A0A5N4AHN6_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_10898</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AHN6"/>
    <dbReference type="FunCoup" id="A0A5N4AHN6">
        <property type="interactions" value="16"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AHN6"/>
    <dbReference type="OrthoDB" id="7663415at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="473"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="504"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="415"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="473"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="516"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0796837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="612" mass="69292" checksum="E81509E9C233096E" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-06-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AIZ7</accession>
    <name>A0A5N4AIZ7_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_08263</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AIZ7"/>
    <dbReference type="InParanoid" id="A0A5N4AIZ7"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0797269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="85" mass="9984" checksum="EDF0C15FAE26BEE1" modified="2020-02-26" version="1">MQRWLDDKNVPYTKKMTKLELYEVIKRHRSQSDTKNVIQSACEHSKKLESQFMESEHVLDISVNDVIIDLGEDDSNESDFCFSDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AJ47</accession>
    <name>A0A5N4AJ47_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Aromatic-L-amino-acid decarboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_08366</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5 6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the group II decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AJ47"/>
    <dbReference type="InParanoid" id="A0A5N4AJ47"/>
    <dbReference type="OrthoDB" id="639767at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004058">
        <property type="term" value="F:aromatic-L-amino-acid decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006584">
        <property type="term" value="P:catecholamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06450">
        <property type="entry name" value="DOPA_deC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1340.10:FF:000001">
        <property type="entry name" value="Histidine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000025">
        <property type="entry name" value="Histidine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1340.10">
        <property type="entry name" value="dopa decarboxylase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010977">
        <property type="entry name" value="Aromatic_deC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999:SF60">
        <property type="entry name" value="3,4-DIHYDROXYPHENYLACETALDEHYDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999">
        <property type="entry name" value="GROUP II PYRIDOXAL-5-PHOSPHATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00800">
        <property type="entry name" value="YHDCRBOXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 5 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5">
        <location>
            <position position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0797372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="503" mass="56877" checksum="357A8864DCA56112" modified="2020-02-26" version="1">MDSDQFREFGKAMVDYIADYLDNIRNRKVLPSVNPGYLQPTIPQEAPQTGENWKSIMEDIERVIMPGVTHWHSPNFHAYCPTANSYPGIVGEMLSAGIGCVGFSWMSSPACTELEVAMMNWLGKLIGLPEEFLNCSNGSGGGIIQGSASESTFIALLTAKERMVRNIKNVHPQLDEGLIKAKLVAYTSDQANSSVEKAGMLGSMPMRLLPTDQNGCLRKETLEEAISNDKNAGLIPCYVVATLGTTGTCAFDNLEELGPVCRREKLWLHIDAAYAGSAFVCPEYRYLMRGVEYADSFDFNPHKWMMVNSDCSAMWVRNSRHIVEAFNVDRIYLHHEHEGVAPDYRHWQISLGRRFRALKLWFVLRSYGVEGIQKHIRSQIELARYFEKLVKDDSRFEFACSSMGLVCFRMKAGDRLTQTLVDKLTQRKNIYVIPCYFQGNYVVRFVVCSRLTEIRDIDYGWSEICEVASEILNGYIPGKPNGELVSLVTVSNMSKRRENCIEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-06-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AJ58</accession>
    <name>A0A5N4AJ58_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_08384</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AJ58"/>
    <dbReference type="InParanoid" id="A0A5N4AJ58"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0797390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="99" mass="11337" checksum="E1BBA455517B9B01" modified="2020-02-26" version="1">MSTKEWLTKKQMEVFESVLKSIGIDKYSIRFSAGVKEGENFAGIIINAEVEDETKIIKSVWNCVIKCVPRSDLFRLYAPVKNMYNVEIYVYIGLPDVPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-06-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AJL6</accession>
    <name>A0A5N4AJL6_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_08535</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AJL6"/>
    <dbReference type="InParanoid" id="A0A5N4AJL6"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0797542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="62" mass="7098" checksum="2452F89B7B47C6B6" modified="2020-02-26" version="1" fragment="single">EIILMENWQTYTHVGNSEGIEQNRATGNYIKVFYLRALYLPSNESSPCGLLHKTKLHFVGTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2024-01-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AJU4</accession>
    <name>A0A5N4AJU4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DDE-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_08615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AJU4"/>
    <dbReference type="InParanoid" id="A0A5N4AJU4"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE-1" evidence="1">
        <location>
            <begin position="2"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0797622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="69" mass="7752" checksum="06040B4E4ECE859A" modified="2020-02-26" version="1" fragment="single">ENGVTMLTFPPHTSHKLQPLDRGVFGPFKKYLNRVSDAWITNNLGKSMSIYDIPGIVKEAWPLAITPKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ALD7</accession>
    <name>A0A5N4ALD7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DDE-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_09109</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ALD7"/>
    <dbReference type="InParanoid" id="A0A5N4ALD7"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF74">
        <property type="entry name" value="POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE-1" evidence="2">
        <location>
            <begin position="12"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="317"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0798116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="421" mass="47084" checksum="1F513EFDD3D726D8" modified="2020-02-26" version="1">MRGAPVNSVSHLTQSGWMDQEGFIMYLRHFATYSHCSPENPVLLILDGHASHKTLSAILKARELGIQLLTIPPHTSHRLQPLDRTFFGPLNIFYNQECSRFMTNNPGKRISVYDIAELFNKGYLKAATMNNAIKGFQTTGIWPFNNELFTEVDYVNVYDKDKENIINSENTIETHPPDREQPRETTPPPGDENPLERYLNTPTRNNEKPQEEIPSSCSTKASRLSRVEEISPLPIATRSGQEKGRKVQKSDILTSTPYKDALESPQNVDGKKRKAASKKLDSDNGTKSITKSIGTKPSVSISKPTKKAKKSKKYKRTASSSSSNMSDEMSIRDSSSDDDIPIHFCLICKEQLAEPPDQEIIMCAMGRGKVDQVGKFRSEALSNLNFALNGRFKLATHIAAITGIVKYVLKCMRTFITVSPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ALZ8</accession>
    <name>A0A5N4ALZ8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ATPase protein 9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">ATPase subunit c</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PPYR_09324</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">1611_PpyrPB1</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the ATPase C chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ALZ8"/>
    <dbReference type="FunCoup" id="A0A5N4ALZ8">
        <property type="interactions" value="281"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4ALZ8"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033177">
        <property type="term" value="C:proton-transporting two-sector ATPase complex, proton-transporting domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18182">
        <property type="entry name" value="ATP-synt_Fo_c_ATP5G3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.20.10:FF:000003">
        <property type="entry name" value="Atp synthase f complex subunit mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.20.10">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01396">
        <property type="entry name" value="ATP_synth_c_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000454">
        <property type="entry name" value="ATP_synth_F0_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020537">
        <property type="entry name" value="ATP_synth_F0_csu_DDCD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038662">
        <property type="entry name" value="ATP_synth_F0_csu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10031">
        <property type="entry name" value="ATP SYNTHASE LIPID-BINDING PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10031:SF0">
        <property type="entry name" value="ATPASE PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00124">
        <property type="entry name" value="ATPASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00605">
        <property type="entry name" value="ATPASE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0138">CF(0)</keyword>
    <keyword evidence="6 14" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8 14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 14" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 14" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="106"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="144"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="15">
        <location>
            <begin position="107"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00033111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAB0798331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="173" mass="18362" checksum="E94E07B56E4B8C01" modified="2020-02-26" version="1">MPSRFATLDRSGHSNEEYLSMFGVKKNQIADMFACAKVIAPLARSAIIASPKTFLRPLSSTLSQSSQLLVQSPVVQQQSQKPTLLPAIRSFQTTAVTRDIDSAAKFIGAGAATVGVAGSGAGIGTVFGSLIIGYARNPSLKQQLFSYAILGFALSEAMGLFCLMMSFLLLFAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AN24</accession>
    <name>A0A5N4AN24_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PPYR_06635</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">1611_PpyrPB1</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Microsome membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 15">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0798755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AN24"/>
    <dbReference type="InParanoid" id="A0A5N4AN24"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11056">
        <property type="entry name" value="CYP6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000182">
        <property type="entry name" value="Cytochrome P450 3A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050476">
        <property type="entry name" value="Insect_CytP450_Detox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292:SF54">
        <property type="entry name" value="CYP9F3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 14 15" id="KW-0349">Heme</keyword>
    <keyword evidence="11 14 15" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0492">Microsome</keyword>
    <keyword evidence="12 15" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="10 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="14">
        <location>
            <position position="448"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAB0798755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="521" mass="60619" checksum="07132CD8B7E1FA98" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ANC1</accession>
    <name>A0A5N4ANC1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Metallo-beta-lactamase domain-containing protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Endoribonuclease MBLAC1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PPYR_06686</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Endoribonuclease that catalyzes the hydrolysis of histone-coding pre-mRNA 3'-end. Involved in histone pre-mRNA processing during the S-phase of the cell cycle, which is required for entering/progressing through S-phase. Cleaves histone pre-mRNA at a major and a minor cleavage site after the 5'-ACCCA-3' and the 5'-ACCCACA-3' sequence, respectively, and located downstream of the stem-loop. May require the presence of the HDE element located at the histone pre-RNA 3'-end to avoid non-specific cleavage.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a ribonucleotidyl-ribonucleotide-RNA + H2O = a 3'-end ribonucleotide-RNA + a 5'-end 5'-phospho-ribonucleoside-RNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:68096"/>
            <dbReference type="Rhea" id="RHEA-COMP:15179"/>
            <dbReference type="Rhea" id="RHEA-COMP:17355"/>
            <dbReference type="Rhea" id="RHEA-COMP:17428"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:74896"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:173118"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:68097"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0798806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ANC1"/>
    <dbReference type="FunCoup" id="A0A5N4ANC1">
        <property type="interactions" value="19"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4ANC1"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07711">
        <property type="entry name" value="MBLAC1-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039344">
        <property type="entry name" value="MBLAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23200">
        <property type="entry name" value="METALLO-BETA-LACTAMASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23200:SF48">
        <property type="entry name" value="METALLO-BETA-LACTAMASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="7">
        <location>
            <begin position="28"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00045869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0798806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="199" mass="22287" checksum="6FDD6AA8BB210677" modified="2020-02-26" version="1">MCAEKSNYEVIVLFTGYSRNTEQGTQANCTCTLLKGPKLVIIDTMTAWDGEILTKALLSNNVNCKDIDFVICTHGHSDHIGCNYLFPEATHIVGNCISHKNNYYAHNFSDSPYKIDENVQIIHTPGHTLQDVTVLVENENGITAIVGDLFENEDDLVDDTIWKNAGSDSQELQFQNRDKILEIADWIVPGHGPMFKLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ANS2</accession>
    <name>A0A5N4ANS2_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_06834</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0798954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ANS2"/>
    <dbReference type="InParanoid" id="A0A5N4ANS2"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF292">
        <property type="entry name" value="DDE TNP4 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="8">
        <location>
            <begin position="144"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0798954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="347" mass="39517" checksum="91DFDE06D32BB589" modified="2020-02-26" version="1" fragment="single">NLDDNAVDDEANHHAQPVRNENYVEVTVPQYTVSEFKNHFRMSRMAVEQLIGLVSNHLPDKHSVPIEKQVLFSIWLLAKQESFLAVGDRFNLSSGSGHYIFMNFISAVGHLTHQFIEWPNARTCNEIASRIETKYGIPGVVGAIDGTHIQIKQPTHNPVDFFNRKDVHSVVLQGICNDKLIFTDVYIGMPGRLHDARIFRNSPIYNRLVNNPALLTPQQHLLGDAAYPLLDNLLKPYRDNGHLTEVQIRFNEVMSSIRSMIERCFGLLKGKWRRLKYLDMSLADKLPQVILAACILHNFILIIDNDADNQNDNGHNGDDIGIQHAEFYEEDVGRNAEIKRDYIASLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ANZ0</accession>
    <name>A0A5N4ANZ0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Translation initiation factor 3 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_06883</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IF-3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ANZ0"/>
    <dbReference type="InParanoid" id="A0A5N4ANZ0"/>
    <dbReference type="OrthoDB" id="21573at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070124">
        <property type="term" value="P:mitochondrial translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032790">
        <property type="term" value="P:ribosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.10">
        <property type="entry name" value="Translation initiation factor 3 (IF-3), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036788">
        <property type="entry name" value="T_IF-3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001288">
        <property type="entry name" value="Translation_initiation_fac_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10938">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10938:SF0">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55200">
        <property type="entry name" value="Translation initiation factor IF3, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0799003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="220" mass="25179" checksum="CF5146A40C5DC493" modified="2020-02-26" version="1">MISVRLNNLRNVCGLHNNFLNTLCKHFSAKPPTTPIQKNAEGETQKRPKSQPVPKITLIVNDDNMSITTLEEAQHMSKRRALKLVKLVDMDNKTQRPVYKLMTGAEYNTEDLKSRQTKKQDKLSNALKGEKLLMLNVQISKHDLEVHVKKIIKWIAKRFEVRVTINGDANNAEKSEAIYKFLEDNLKTETRFLQKRMKGGDLKFQIIPPKADDAGSNKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AQG9</accession>
    <name>A0A5N4AQG9_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_07485</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AQG9"/>
    <dbReference type="FunCoup" id="A0A5N4AQG9">
        <property type="interactions" value="7"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AQG9"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1820">
        <property type="entry name" value="L1 transposable element, RRM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004244">
        <property type="entry name" value="Transposase_22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11505">
        <property type="entry name" value="L1 TRANSPOSABLE ELEMENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="306"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="366"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="633"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="693"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1163"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="31"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="96"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="113"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="152"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="306"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="400"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="416"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="456"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="502"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="549"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="571"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="700"/>
            <end position="716"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0799605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1268" mass="141376" checksum="6AFC1630E4F8DFF5" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AR77</accession>
    <name>A0A5N4AR77_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sulfatase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_07710</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sulfatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AR77"/>
    <dbReference type="FunCoup" id="A0A5N4AR77">
        <property type="interactions" value="81"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AR77"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16029">
        <property type="entry name" value="4-S"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047115">
        <property type="entry name" value="ARSB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10342">
        <property type="entry name" value="ARYLSULFATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10342:SF273">
        <property type="entry name" value="RE14504P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00149">
        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024296705" description="Sulfatase N-terminal domain-containing protein" evidence="7">
        <location>
            <begin position="25"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase N-terminal" evidence="8">
        <location>
            <begin position="27"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase N-terminal" evidence="8">
        <location>
            <begin position="546"/>
            <end position="867"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0799830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1062" mass="118674" checksum="096C4FFFB7AC63D4" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ARF5</accession>
    <name>A0A5N4ARF5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Hemolymph juvenile hormone-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_07790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ARF5"/>
    <dbReference type="InParanoid" id="A0A5N4ARF5"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.30">
        <property type="entry name" value="Haemolymph juvenile hormone binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010562">
        <property type="entry name" value="Haemolymph_juvenile_hormone-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038606">
        <property type="entry name" value="To_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008:SF32">
        <property type="entry name" value="CIRCADIAN CLOCK-CONTROLLED PROTEIN DAYWAKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008">
        <property type="entry name" value="PROTEIN TAKEOUT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06585">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00700">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0799910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="272" mass="30720" checksum="8210FE8DBCECBED6" modified="2020-02-26" version="1">MFTQFRRYKGPAILNLTDHCECQISGQHFILRIPQMKLFLVLLAFAHVSKGQKLPDDFKVCDHFASDINECLGVAFASALKQLKNGIPAINASPIDPYRLSNMTIVRKDHAIGFYDIDLYNFTTGKLDYIDTKITRDSFFAKMNISMPVITALADYTLKGKLFLFNIEAKGKGVLTMKNTEFTILMSGPVIKDAAGAERFKLTTFESKIHPKSVTFNFGDLVPGQKMVTDQVNAVLTENWEILYKEVESELEKVSSEHLLDYSNNILQYVPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ARS7</accession>
    <name>A0A5N4ARS7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Death domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_07911</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0800031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ARS7"/>
    <dbReference type="InParanoid" id="A0A5N4ARS7"/>
    <dbReference type="OrthoDB" id="6066069at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024362678" description="Death domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0800031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="224" mass="26500" checksum="A71F1D8EF4027A68" modified="2020-02-26" version="1">MWHIQKLLLIFTYNYLSWATIDLNIAEFQYLADHLHPEECRRLVASLHFSSYKEPKALDVAEENVSKDIPCIRLLLHWNSQKGEGKGETHEVVQHRLRQLGRADLADWLGKTVFHELGEELMEELKNPFDTVINVTERQTYRMPQTLSTEYKWDPTEWLAFDTICWAVIIGLTSFAFFLLIKAAFILFMRKIRRFPPRKYRTLRTDEGSDSEELFDIRTHNNNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ARU7</accession>
    <name>A0A5N4ARU7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">DnaJ homolog l(2)tid, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Protein lethal(2)tumorous imaginal discs</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PPYR_07931</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">1611_PpyrPB1</strain>
            <tissue evidence="19">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0800051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ARU7"/>
    <dbReference type="FunCoup" id="A0A5N4ARU7">
        <property type="interactions" value="1832"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4ARU7"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000005">
        <property type="entry name" value="Chaperone protein dnaJ 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.230.10:FF:000003">
        <property type="entry name" value="dnaJ homolog subfamily A member 3, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000075">
        <property type="entry name" value="Uncharacterized protein, isoform D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051938">
        <property type="entry name" value="Apopto_cytoskel_mod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44145">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY A MEMBER 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44145:SF3">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY A MEMBER 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0007">Acetylation</keyword>
    <keyword evidence="13" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="8 16" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="17">
        <location>
            <begin position="75"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="18">
        <location>
            <begin position="216"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="16">
        <location>
            <begin position="216"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00080150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00093620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAB0800051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="442" mass="49424" checksum="E89CF9AACFCC7A2D" modified="2020-02-26" version="1">MATARCLISTFNPRNVNLLVTYLPNTTISQRLFHHCIKSHRNTSFRLGFWNTSNNHLQVTKYNNFHTTNLLNKDDYYQTLGVSRNASTAEIKKAYYKLAKQFHPDVNKDPGAAKKFQAVSEAYEILGDDTKRKQYDTWGSTAEQMGNMGGAGRNAQGFSQQWNYQSSIDPEELFRKIFGESGFQRGSFDDFAESSFGFGGAKEAVIRLTFTQAARGTTKDININVVDTCNKCNGSRCEPGTKAVRCTYCNGTGFESISRGPFIMSSTCRYCQGTRMHIKFKCTECEGKGSTVQRKTVTVPVPAGIDDGQTIRMTVGKDELFVTFKVEKSKYFKRDGHDVHTEADISVSQALLGGTIRIQGLYEDHTIQVMPGTSSHTRIRLSSKGMKKPNGYGYGDHYVNFKIIVPKNLSSNQKALVTAYAELEQDTPGQIYGMTYKNDGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ARX0</accession>
    <name>A0A5N4ARX0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">LRRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_07838</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ARX0"/>
    <dbReference type="InParanoid" id="A0A5N4ARX0"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366">
        <property type="entry name" value="IG(IMMUNOGLOBULIN) AND LRR(LEUCINE RICH REPEAT) DOMAINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366:SF96">
        <property type="entry name" value="LEUCINE RICH REPEAT CONTAINING 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024402900" description="LRRCT domain-containing protein" evidence="3">
        <location>
            <begin position="21"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0799958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="396" mass="43292" checksum="98D8D284ABD2710C" modified="2020-02-26" version="1">MTGCCAWRYVYAVVLVQATAFNMILPSVCPPECICLSQTQVLCNSGGLTEIPVKLLPPTVEHLSLTRNNFPTIRSDAFAGLRALKKLSLDGNNISIIKPFAFRGLPRLKELSIQQTPLTTVAQFAFAGLQNITSILLSHNKIKKVEGYAFAGTSNLKHLILSSNPIIKIESNAFSGLTNVERLALPSGIRTIEVDAFNGLEQVGVLKLAFMDLPSLKFGTFRGLTIVGVMSIQESDLGIIREGAFEGLSYIGSLNFLNNKIDGIRELHITPEHHIRSIKFQGNHVLDIPKADSVSFAVDVLTVISNHFPCDCHIHTLIEGPLANGSVEQFISKNYCISPLEVNGKAMSNLDLDAIGKCEEQVTRGNLEAAKDSTSINKSVRVTVLFTFVVFVYFSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-06-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ASV9</accession>
    <name>A0A5N4ASV9_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_06147</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000004">
        <property type="protein sequence ID" value="KAB0800407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ASV9"/>
    <dbReference type="InParanoid" id="A0A5N4ASV9"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0800407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="108" mass="12466" checksum="F4C483246C9DAF6F" modified="2020-02-26" version="1">MISHSNFRYNRYSTIARVQKQWHSTSVSNTVIRRHVNAKNEIITFNLIFLRSDSDTEGDDDFQPLPYVNFDTSDSEAEGDSEAVNNNNNVPPPPTSSPIPREYLYNDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ATC0</accession>
    <name>A0A5N4ATC0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosome receptor lysine/proline rich domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_06296</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000004">
        <property type="protein sequence ID" value="KAB0800556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ATC0"/>
    <dbReference type="InParanoid" id="A0A5N4ATC0"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040248">
        <property type="entry name" value="RRBP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18939">
        <property type="entry name" value="RIBOSOME BINDING PROTEIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18939:SF4">
        <property type="entry name" value="RIBOSOME-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="45"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="297"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="511"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="687"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="52"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="161"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="213"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0800556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="864" mass="98526" checksum="E8E0E35AA84F685F" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ATT7</accession>
    <name>A0A5N4ATT7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PPYR_06468</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">1611_PpyrPB1</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000004">
        <property type="protein sequence ID" value="KAB0800729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ATT7"/>
    <dbReference type="FunCoup" id="A0A5N4ATT7">
        <property type="interactions" value="317"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4ATT7"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11056">
        <property type="entry name" value="CYP6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000042">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050476">
        <property type="entry name" value="Insect_CytP450_Detox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292:SF103">
        <property type="entry name" value="CYTOCHROME P450 6BS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0492">Microsome</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="455"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAB0800729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="513" mass="58846" checksum="FA9EEE863A3583D3" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AUU5</accession>
    <name>A0A5N4AUU5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_05451</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000003">
        <property type="protein sequence ID" value="KAB0801097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AUU5"/>
    <dbReference type="InParanoid" id="A0A5N4AUU5"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048366">
        <property type="entry name" value="TNP-like_GBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048367">
        <property type="entry name" value="TNP-like_RNaseH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048365">
        <property type="entry name" value="TNP-like_RNaseH_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21788">
        <property type="entry name" value="TNP-like_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21789">
        <property type="entry name" value="TNP-like_RNaseH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21787">
        <property type="entry name" value="TNP-like_RNaseH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0801097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="951" mass="109301" checksum="49D0785ADF4B3F8E" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AVA8</accession>
    <name>A0A5N4AVA8_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_05611</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000003">
        <property type="protein sequence ID" value="KAB0801257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AVA8"/>
    <dbReference type="InParanoid" id="A0A5N4AVA8"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026103">
        <property type="entry name" value="HARBI1_animal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF85">
        <property type="entry name" value="GH03217P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02086">
        <property type="entry name" value="PUTNUCHARBI1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0801257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="191" mass="22121" checksum="E82A98FB070154C9" modified="2020-02-26" version="1">MMKNFFNKERSGNFARITDYADVVGRYADNEFKSHFRMSKSTFEYLVNIIRGDLIRKVNGCPTIPAEKQLMIALWKMATSDSYRSVCDRFNVGKATGLRAVRRVTYSLHKRAARWIQWPVGDRAITVMQQFEASSGFPRVIGAIDGTHIRIDAPQENAPDYVNRKHFHSIQLQVGNNCQKIMFINREIWKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AVE9</accession>
    <name>A0A5N4AVE9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PPYR_05675</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000003">
        <property type="protein sequence ID" value="KAB0801321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AVE9"/>
    <dbReference type="FunCoup" id="A0A5N4AVE9">
        <property type="interactions" value="110"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AVE9"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990246">
        <property type="term" value="C:uniplex complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036444">
        <property type="term" value="P:calcium import into the mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051560">
        <property type="term" value="P:mitochondrial calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16175">
        <property type="entry name" value="EFh_MICU3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039800">
        <property type="entry name" value="MICU1/2/3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12294">
        <property type="entry name" value="EF HAND DOMAIN FAMILY A1,A2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12294:SF13">
        <property type="entry name" value="MITOCHONDRIAL CALCIUM UPTAKE 3, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00036">
        <property type="entry name" value="EF-hand_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="170"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="375"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0801321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="436" mass="50582" checksum="63FC6BAD76AC711B" modified="2020-02-26" version="1">MAIIGRSILRALQAKLTNSVRNISKFSHNKVKYYNTNSLSAVIVAGGTIAIYTAYQCVASKSVLAYQPKNAEEGVRAVRLTSRERRFIRFASVEFDGQLYMTPQDFLESVVEADPRPRLKRKMLTTSDMEYMKGHTPSLNQGSPRLFRNLRDKGIISYTEYLFLLSVLTKPQSGFRIAFNMFDTDGNQRVDKNEFLVMEKIFSHAWKGKRGLAIAEDLTKIKVPSEEYVDDEQGLQRRHAVDTTLIIHFFGPKGNEELKFEGFRRFMLDLQTEVLELEFSEFSKGLQTISEVDFAKILLRYTYLDTDEYDMYLDRLLDRIKDTKGITFEEFYIFCQFLNNLEDFTIAMRMYTLADHPISKDEFHRAVKICTGTSLSQHIVHTVFSIFDEDGDGLLSYREFIAIMKDRLHRGFRSYAKNEGWDAFRNCLKQEMKSPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AVJ0</accession>
    <name>A0A5N4AVJ0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PPYR_05627</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000003">
        <property type="protein sequence ID" value="KAB0801273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AVJ0"/>
    <dbReference type="FunCoup" id="A0A5N4AVJ0">
        <property type="interactions" value="2004"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AVJ0"/>
    <dbReference type="OrthoDB" id="332281at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009316">
        <property type="entry name" value="COG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024603">
        <property type="entry name" value="COG_complex_COG2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024602">
        <property type="entry name" value="COG_su2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12961">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12961:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12022">
        <property type="entry name" value="COG2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06148">
        <property type="entry name" value="COG2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 2 N-terminal" evidence="9">
        <location>
            <begin position="9"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="COG complex component COG2 C-terminal" evidence="10">
        <location>
            <begin position="345"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF06148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0801273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="678" mass="78002" checksum="DB4B5C87C954F814" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AW64</accession>
    <name>A0A5N4AW64_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_03760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0801574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AW64"/>
    <dbReference type="InParanoid" id="A0A5N4AW64"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1820">
        <property type="entry name" value="L1 transposable element, RRM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004244">
        <property type="entry name" value="Transposase_22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11505">
        <property type="entry name" value="L1 TRANSPOSABLE ELEMENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0801574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="175" mass="20260" checksum="1BC9D11D3AA1DA9B" modified="2020-02-26" version="1">MDEKIDVISAAIKTLTVTSNETVGRVAKVEADHDALEQYTRRNNLRISGILETANENCDQLVVQFLENKLNITCTELDIERTHRVGKRQDGVKRAIIVKFASYRKRAEIFASKKLLKKTGFLISEDLTALRYQLYKQYCEIYAKPNVWTTDGRIHYIDKNNSHQILKPLDYIIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AWB7</accession>
    <name>A0A5N4AWB7_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_03810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0801624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AWB7"/>
    <dbReference type="InParanoid" id="A0A5N4AWB7"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017956">
        <property type="entry name" value="AT_hook_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38681:SF1">
        <property type="entry name" value="RETROVIRUS-RELATED POL POLYPROTEIN FROM TRANSPOSON 412-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38681">
        <property type="entry name" value="RETROVIRUS-RELATED POL POLYPROTEIN FROM TRANSPOSON 412-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02178">
        <property type="entry name" value="AT_hook"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00384">
        <property type="entry name" value="AT_hook"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0801624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="256" mass="28568" checksum="705F4596549331FA" modified="2020-02-26" version="1">MKPTPASNHNTQKSTFQLKDINTATHVYIRVDAAKRPLQAPYEGPYPVVTRNDKTTTIRRHGTDITVSNDRVKPAYQETDEEQADTSKVVPPSPVPPAKRPVGRPPKLSTPPAEAQTAKRPVGRPRKYREEKPQPKPTTTVPTTTRSGRQSKPRVRFQLAAITTTPSPARGYMWRPAPKTYTIKHGRDYPQLGTAVKHGREHPGASKHGRDMQNSSSPLKRTAFIRRAGSWRNQMHLFPNSGHLASTALPNSQYPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AWD3</accession>
    <name>A0A5N4AWD3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Complex I-49kD</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">NADH-ubiquinone oxidoreductase 49 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_03835</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the complex I 49 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0801649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AWD3"/>
    <dbReference type="InParanoid" id="A0A5N4AWD3"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.645.10">
        <property type="entry name" value="Cytochrome-c3 Hydrogenase, chain B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01358">
        <property type="entry name" value="NDH1_NuoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001135">
        <property type="entry name" value="NADH_Q_OxRdtase_suD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014029">
        <property type="entry name" value="NADH_UbQ_OxRdtase_49kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022885">
        <property type="entry name" value="NDH1_su_D/H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029014">
        <property type="entry name" value="NiFe-Hase_large"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01962">
        <property type="entry name" value="NuoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004739">
        <property type="entry name" value="PRK06075.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11993:SF10">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11993">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 49 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00346">
        <property type="entry name" value="Complex1_49kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56762">
        <property type="entry name" value="HydB/Nqo4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00535">
        <property type="entry name" value="COMPLEX1_49K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NADH-quinone oxidoreductase subunit D" evidence="8">
        <location>
            <begin position="179"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0801649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="450" mass="51763" checksum="C2DDE2D6843E00AD" modified="2020-02-26" version="1">MSLLSRILMKISSRPNTRFMQKWYPDAEWFRQFDGPVMFNREKFKHWKIQPWNGKLPMVEKKVRNMVINFGPAHPAAHGVLRLICELEGEVIRRIDPHIGHLHRGTEKLCEHKTYLQALPYFDRFDYVSPMCNEHAFCLALEKLLNIDIPRRAKFIRTIFIELTRLLSHGLSAASQLLDAGAITPVFWVFEEREKIWEFCERVSGGRVHSIYFRVGGVARDLPIGLLDDIQLFTERFCQRLDEIEDVTTNNRIWLARNVGIGAISAEDAINTGCSGTNLRATGVKWDLRKNLPYEIYDELDFDVPVGANGDCHDRWLCKMYEMRQSCRIIGQCLNKMPEGDVKVDDYKITPPTRMEMKQSMECVIHHFKLFSSGFAVPPGCTYVGTEHPKGEFGVYVVSDGSSRPYRVKVRPPGFAHLGAMKYFLKPDTMLADIPVMIASLEFVLGDIDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AXF9</accession>
    <name>A0A5N4AXF9_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PPYR_04238</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA2/NAM7 helicase family. SDE3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AXF9"/>
    <dbReference type="InParanoid" id="A0A5N4AXF9"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049080">
        <property type="entry name" value="MOV-10-like_beta-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45418">
        <property type="entry name" value="CANCER/TESTIS ANTIGEN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45418:SF1">
        <property type="entry name" value="CANCER_TESTIS ANTIGEN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21634">
        <property type="entry name" value="MOV-10_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase MOV-10-like beta-barrel" evidence="9">
        <location>
            <begin position="56"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="8">
        <location>
            <begin position="195"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0802052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="323" mass="36572" checksum="2C06D3838DAD44AA" modified="2020-02-26" version="1">MGITRYQSITPEEDISLRHVEHLLHPGYVTQHNYKDFFHIALWVDEKGAELMLQRYNMENVNITVIQKTLLELEVPGLAEKRPSLIRGDVVNLRLHGDHIGYKGVISRVNNLSIYIQGVDELLIEYIRSNPDAEIDVSFKLGRLPYERMHNGVDHCVSSGMTNYLFPDNIISNVGILAGRRLPDTEFFNPAIRGNPEQRSAVESILFRSNFAPYIVFGPPGTGKTITIVEAILQLVKKIPGVVILVCAPANAACDMLASKLIQSKRLTEKELIRVHTDTREWDTVPEDVKGYSNYVDGEYIKPRGFELMKYRVIVTTLILSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AYA5</accession>
    <name>A0A5N4AYA5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serpin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_04414</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the serpin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AYA5"/>
    <dbReference type="InParanoid" id="A0A5N4AYA5"/>
    <dbReference type="OrthoDB" id="9518664at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00172">
        <property type="entry name" value="serpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.39.10">
        <property type="entry name" value="Alpha-1-antitrypsin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.497.10">
        <property type="entry name" value="Antithrombin, subunit I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023796">
        <property type="entry name" value="Serpin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000215">
        <property type="entry name" value="Serpin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036186">
        <property type="entry name" value="Serpin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042178">
        <property type="entry name" value="Serpin_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042185">
        <property type="entry name" value="Serpin_sf_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461:SF211">
        <property type="entry name" value="GH10112P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR, SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00079">
        <property type="entry name" value="Serpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00093">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56574">
        <property type="entry name" value="Serpins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024412538" description="Serpin domain-containing protein" evidence="5">
        <location>
            <begin position="20"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="Serpin" evidence="6">
        <location>
            <begin position="35"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0802228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="390" mass="44919" checksum="82D175CB69780C36" modified="2020-02-26" version="1">MYRLLFIFCLYLLIKNAEGSKLQINFYDANLNFTIEFYKAVMYQNPNVNFLISPIAAQLSLGLAHFGAKGNTAEELSPQLQKFTNQDLKHLYSSVSSRFKSKSGYKFDLVNTFFISKKYRISKEYLEWAKNPFGSLVQPINFEKVKTTVRNINTWVRQNTDHKVNNILTATDIDEKTTALLLNALYFQGYWLRQFDPKKTQRMSFYKNCEETALVDMMIAKDTFNYYADDELGAQFLEIPFKGHSVSMTIVLPRTKFGLHNLEARIADVLVPKNYEEDIVDVMIPKFRIGYKLNMKSTLLAMNVHTPFQCTADFSGISTSSPPLHLNEVIQKTYVEINEKGATNAKAFSYGALSPRSKGTSFVANYPFLYYFKHKVSGIFFIGRYLFPEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AYR1</accession>
    <name>A0A5N4AYR1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ER membrane protein complex subunit 6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Transmembrane protein 93</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PPYR_04574</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMC6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AYR1"/>
    <dbReference type="FunCoup" id="A0A5N4AYR1">
        <property type="interactions" value="912"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AYR1"/>
    <dbReference type="OrthoDB" id="16510at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008504">
        <property type="entry name" value="Emc6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029008">
        <property type="entry name" value="EMC6-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20994">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20994:SF0">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07019">
        <property type="entry name" value="EMC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0802388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="111" mass="12283" checksum="D4A7FE6EFD1C7259" modified="2020-02-26" version="1">MSNKSKTKSSDVVAYSEVAMRNNSAVVEYCRTSMAALSGCTAGMLGFTGLYGAAFYIFAVTGLWGMLLLKAGSNWQEYFVSRKALLTNGFFGQLFTYVLCWTFIYGMVHVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AZ33</accession>
    <name>A0A5N4AZ33_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_04791</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AZ33"/>
    <dbReference type="InParanoid" id="A0A5N4AZ33"/>
    <dbReference type="OrthoDB" id="1107553at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000012">
        <property type="entry name" value="F-box only protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007397">
        <property type="entry name" value="F-box-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039752">
        <property type="entry name" value="F-box_only"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12125:SF5">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12125">
        <property type="entry name" value="F-BOX ONLY PROTEIN 6-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04300">
        <property type="entry name" value="FBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01198">
        <property type="entry name" value="FBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51114">
        <property type="entry name" value="FBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="28"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="FBA" evidence="2">
        <location>
            <begin position="89"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0802605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="341" mass="39996" checksum="01D7A7AFBB698C53" modified="2020-02-26" version="1">MSDMEVASYLPLFLREEYTEVDTENGLFLCNMHIPEEILLHILSFVDPKVLLRYSIVCKKWNLLIKSFPLWSIIYRRKFQRKPKKLPWYIFYCRFSTEYFDINLLKNGSGQDSFNNWEIIENGGDKFVVEDPPDGADALNIEEPEFENKTSCFATSYGNCKKIQVVKFGQSKLFRYILSNYKPHIYLSEWTCGRFDCGSLYRLRCSYLGIIPDVTIAKPSAGQTVKQWEGRKWNKIEILITQYPEGVEGISFEHDGRDTQFWAGHYGSKMAGGVVKLLFDSIDPLPLNNLGQKQPKRFSKTEYKTNGENLDNYFMEIEIERIRPICRYPPHVRRNIREAYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-06-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B018</accession>
    <name>A0A5N4B018_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_05110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B018"/>
    <dbReference type="InParanoid" id="A0A5N4B018"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0802924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="233" mass="26700" checksum="6FFBA08E896FF109" modified="2020-02-26" version="1">MVHTRDHHRQIKNHEPRECTSINSMNTNKLVHPSEAVLYTGPSNVQDNRMVWAALTPRGTQHFISENYPRNLIDYEDHYETVDNLNIQPVATVTYTTCQKGLELKLARENKGIDNSGFVDYDYEDPTPLIESYQMNDIENRDDSPYYSSFGNTDMRCASLGSSYRRGIALNLPLRPRVSSPTRIEHPNLPPLNLYPHKGANATITLKRNNLTYRRADSIPYRSNDAILPKYGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B0B7</accession>
    <name>A0A5N4B0B7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PPYR_05210</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0803024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B0B7"/>
    <dbReference type="InParanoid" id="A0A5N4B0B7"/>
    <dbReference type="OrthoDB" id="1095242at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24376:SF243">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24376">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="88"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="245"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="355"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="383"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0803024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="534" mass="63782" checksum="513B8D94D868B3B9" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-06-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B0F7</accession>
    <name>A0A5N4B0F7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DDE-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_00034</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B0F7"/>
    <dbReference type="InParanoid" id="A0A5N4B0F7"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE-1" evidence="1">
        <location>
            <begin position="18"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0803064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="109" mass="12909" checksum="DEA17CD5D8C5EE76" modified="2020-02-26" version="1">MRRVLLKAAPSQTHYYNLASHFTEEVIRLCEENDIGFVCLPKNATHLCQPLDVGFLDRLKWPGEKFSWTGRKHIPLIHRLTKKDFPQLLQTILLRMDNKDKIKKRTFSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B0K2</accession>
    <name>A0A5N4B0K2_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_00101</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B0K2"/>
    <dbReference type="InParanoid" id="A0A5N4B0K2"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0803131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="201" mass="23209" checksum="9458A890384D64F0" modified="2020-02-26" version="1">MDDDVQISAAAFIILCDAIKKKQRKRRRYWMTNLFKSRNIYSGSNLLNDLSLSRTGQFKNFCRISCEDFEYLIHLIGHKIAKQETTFRQPIPVKERLAVTLRFLATGDSYTSLMYLFKISKQSTSTIVTEVCQALCDALKDYVKDGLLIEGTWRRDGNPENSFLPIRRLPRKSPLNAQQIRNELAEYFSSNGAVSFQDKYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B0Y2</accession>
    <name>A0A5N4B0Y2_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FLYWCH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_00040</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B0Y2"/>
    <dbReference type="InParanoid" id="A0A5N4B0Y2"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007588">
        <property type="entry name" value="Znf_FLYWCH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04500">
        <property type="entry name" value="FLYWCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FLYWCH-type" evidence="4">
        <location>
            <begin position="7"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0803070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="107" mass="12470" checksum="29253A9C26B2DF13" modified="2020-02-26" version="1">MDVEILSEKGKQKFTENGFIYVFDTFSKSDNSIKFWRCEKRKECKARVHTRNGEVLKKINDHCHDSSAVSVEVAQVVTKVKKRAVETIEGTIQVITRTLYFQTSYYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B1I0</accession>
    <name>A0A5N4B1I0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MULE transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_00427</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B1I0"/>
    <dbReference type="InParanoid" id="A0A5N4B1I0"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47160:SF5">
        <property type="entry name" value="MULE TRANSPOSASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47160">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0803457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="342" mass="39666" checksum="762BF9EEB2AD7BC2" modified="2020-02-26" version="1">MEQTSQVLNACTSNISQASLPNNYALKKMVRRQRNELKRAPPNPQSVEELIIPDEYTIYHAEPGRNENFLLFQETKDLLIFGRESWLAHLSSKTWFVDGTFKIAPPLYAQVYVLMNANPDSIFCDYESAALLAMRECFPNVSVKGCFFHLAKNMRKKLADLNLIQTYNTDAEFALKAKMVIAISFVPLDHLDEALDSLADVLPPELHPLLNWFEDNYVGRLNRRGNGRRAPIFESSIWNLYERTLHEEDRTNNHSEAAHRRLQTELGVLHPTLWKFIDALRAVQHGRDIYYESLVAGNNPPKKLRRYRDADRRILQIVRNFAQYEAIEEYLRGIAHNYQMGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B2A3</accession>
    <name>A0A5N4B2A3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transposable element P transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_00709</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B2A3"/>
    <dbReference type="InParanoid" id="A0A5N4B2A3"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021896">
        <property type="entry name" value="THAP9-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048366">
        <property type="entry name" value="TNP-like_GBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048365">
        <property type="entry name" value="TNP-like_RNaseH_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21788">
        <property type="entry name" value="TNP-like_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21787">
        <property type="entry name" value="TNP-like_RNaseH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12017">
        <property type="entry name" value="Tnp_P_element"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THAP9-like helix-turn-helix" evidence="1">
        <location>
            <begin position="91"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Transposable element P transposase-like RNase H" evidence="2">
        <location>
            <begin position="177"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="Transposable element P transposase-like GTP-binding insertion" evidence="3">
        <location>
            <begin position="343"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0803739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="432" mass="49976" checksum="3B7EFC0EDB539A7B" modified="2020-02-26" version="1">MEAEYGIEISGSSEQFNQEAPEDTLNKRTQPMEVNSVRVIKKRRLSLLKDVGVTRSSQLDPRANLLYKKLTTWSVKMARMARKITSYKIRLQKAQLCNSEGFQKIMSQVNNYTHQFILSQIRNQERALKCRRYTLEDKILALSLYKASGKGYRLLSKIFALPHPRTLSKLLQKIPLQPGINEIIFKSLQENIRGMKKDDKICILMFDEMSIDVNVYYNRHNDIIVGIEDFGHKRSSKLADHVNLFMLRGLHRQWRQPVSFTFSSGPVTSENLKYQLTEVIKNCLEIGLDVVATVCDQGASNQAAINSLIKDTREHFLREGQENRLFGFLVNNQEIVPFYDVPHLLKGIRNNLLNKDLHFVMNNKKGIASWKHIVKFHNLDSSEPTLRLCSKLTDEHVVPEKIKKMKVSYCTQVFSYTVGSLMMRLSKWGNYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B3W0</accession>
    <name>A0A5N4B3W0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sanpodo</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_01245</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B3W0"/>
    <dbReference type="FunCoup" id="A0A5N4B3W0">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4B3W0"/>
    <dbReference type="OrthoDB" id="8186197at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="388"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="417"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="455"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="487"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0804275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="530" mass="60032" checksum="1CD79BAEC7397336" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B4J7</accession>
    <name>A0A5N4B4J7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_01428</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B4J7"/>
    <dbReference type="InParanoid" id="A0A5N4B4J7"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33053">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33053:SF24">
        <property type="entry name" value="TRANSPOSASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="795"/>
            <end position="826"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0804458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="960" mass="109383" checksum="4E29AD90975EF778" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B7V0</accession>
    <name>A0A5N4B7V0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DDE-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_02410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0805440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B7V0"/>
    <dbReference type="InParanoid" id="A0A5N4B7V0"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF74">
        <property type="entry name" value="POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE-1" evidence="2">
        <location>
            <begin position="92"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0805440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="481" mass="54741" checksum="831C483FA25D063C" modified="2020-02-26" version="1">MPGEGWFNGLMKRHPRLTIKLAENTKRVRAAVTYEIIEDYFRNVSKIIEDIPAQNIVNYDETNFVDDPGAVKVVMKKGSKHAYRTLDTTKSSTTVMFAIAADGTRLPPYTVYKAKYLYEGWKEGGLPGAMYNRSPKGWFDSELFDDWFRSVALPFFRKLDGTKLLIGDNLQSHITVSVIEECENNDIRFILLPPNSTHMLQPLDVAYFRPLKASWKRVLEEWKLKNRGVLPKTVFPRMLKSAVEGLGEREMNNILAGFKACGLVPFNPDAVLAKIARKEPTTPEERNRAETSMTSALVDYLHQLKTGPSDAPKRGKRLNIAAGKSIGTKDLEEENPRSCKQSKTRKRQISDSEDENDLQTLEVEEQSVNIDDYEIGESSAEPEDIPDSSGGCDIGDFIITKYETNKRDRFYIAKIIEMTETELVVSTLRKHASNKSVFFSFPNILDESVINRQQIVRRVILKSLKRGKYYFSLGEELETLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B801</accession>
    <name>A0A5N4B801_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_02656</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0805686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B801"/>
    <dbReference type="InParanoid" id="A0A5N4B801"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF71">
        <property type="entry name" value="ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="2">
        <location>
            <begin position="46"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0805686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="349" mass="39864" checksum="179C3D8A77C9B91F" modified="2020-02-26" version="1">MFLKGQHMSLRTVAADFDINYQTLQRFCKKKRVQNNEGMEQAITVGYKRNRQVLPDEMEIELAGYLIEQSKLYFGLSTKEVRRLAYEFAVKNNVPVRPNWVENEMASADWLTGFLKRHQTLSLRTPEATSLSRSTSFNKKNVDTFFSLLQDVLDRYRFEAQDIYNVDDMGITTVQKPDRVIARKGIKQIGFVTSAERGALVTFCLAVSASGNSIPPMFLFPRKNYRDYFVGNGPQGCIGAANPSGWMTENEFYVFLQHFAKHSRASKEKPVLLLLDNHESHLSLKGITFCKDNGVIVMSLPPHCSHKLQPLDRSVYGPLKKYINTACDSWMRNNPGKTIGLQRYEIVHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1JQS5</accession>
    <name>A0A1Y1JQS5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_00455</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GEZM01103152">
        <property type="protein sequence ID" value="JAV51512.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1JQS5"/>
    <dbReference type="InParanoid" id="A0A1Y1JQS5"/>
    <dbReference type="OrthoDB" id="272624at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000126">
        <property type="term" value="C:transcription factor TFIIIB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001156">
        <property type="term" value="F:TFIIIC-class transcription factor complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070898">
        <property type="term" value="P:RNA polymerase III preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039467">
        <property type="entry name" value="TFIIIB_B''_Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22929">
        <property type="entry name" value="RNA POLYMERASE III TRANSCRIPTION INITIATION FACTOR B"/>
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        </location>
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        <source>
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        <source>
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        <source>
            <dbReference type="SMART" id="SM00717"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="JAV51512.1"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAB0803485.1"/>
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        <source>
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    </evidence>
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</entry>
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    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
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                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
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    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
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        </source>
    </reference>
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    </evidence>
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</entry>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
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                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
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            <dbReference type="PubMed" id="30324905"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="3" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">1611_PpyrPB1</strain>
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        </source>
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        <property type="molecule type" value="Transcribed_RNA"/>
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            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="JAV54262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0791009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="158" mass="18400" checksum="07841CC5C510DAE8" modified="2017-08-30" version="1">MLSNFSSLDEEIENLNHEDLCEITHSTLRRLLAADPLLSDLPGDVTNEEVISQIAVLQGQSITVFVLRNLESPLAVVIPQQGTTVRDLKKAIQRNFDLKQQRLRSKTKVSWRYVWRTYHLQHDLVTMKDNNELVINYGVTNKSEIRFVKRLHKDDRYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1JYK0</accession>
    <name>A0A1Y1JYK0_PHOPY</name>
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            <fullName evidence="6">HIG1 domain-containing protein</fullName>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GEZM01097425">
        <property type="protein sequence ID" value="JAV54213.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0794730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1JYK0"/>
    <dbReference type="FunCoup" id="A0A1Y1JYK0">
        <property type="interactions" value="367"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1JYK0"/>
    <dbReference type="OrthoDB" id="6604018at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097250">
        <property type="term" value="P:mitochondrial respirasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007667">
        <property type="entry name" value="Hypoxia_induced_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050355">
        <property type="entry name" value="RCF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12297:SF18">
        <property type="entry name" value="HIG1 DOMAIN FAMILY MEMBER 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12297">
        <property type="entry name" value="HYPOXIA-INDUCBILE GENE 1 HIG1 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04588">
        <property type="entry name" value="HIG_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51503">
        <property type="entry name" value="HIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="HIG1" evidence="6">
        <location>
            <begin position="15"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="JAV54213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0794730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="102" mass="11414" checksum="0906877A282B7FB7" modified="2017-08-30" version="1">MVVKVESPPPELEWIKLSDDLDKMAQAETMQAKMKRKMKENPLVPIGCLATVAALCYGLWSFKQGRPQMSQKMMRMRIAAQGFTIVAFIVGLGLTARNATNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1K3D7</accession>
    <name>A0A1Y1K3D7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">Aminopeptidase</fullName>
            <ecNumber evidence="23">3.4.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="29" type="ORF">PPYR_06809</name>
    </gene>
    <organism evidence="28">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="28" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="29 30" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="29">1611_PpyrPB1</strain>
            <tissue evidence="29">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="29" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="29">1611_PpyrPB1</strain>
            <tissue evidence="29">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal amino acid, Xaa-|-Yaa- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide.</text>
            <dbReference type="EC" id="3.4.11.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="21 23">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="21 23">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 23">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-" evidence="23"/>
    <dbReference type="EMBL" id="GEZM01096234">
        <property type="protein sequence ID" value="JAV55018.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0798929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1K3D7"/>
    <dbReference type="FunCoup" id="A0A1Y1K3D7">
        <property type="interactions" value="93"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1K3D7"/>
    <dbReference type="OrthoDB" id="510539at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016285">
        <property type="term" value="F:alanyl aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09601">
        <property type="entry name" value="M1_APN-Q_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.50.20:FF:000001">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1910:FF:000008">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1730:FF:000012">
        <property type="entry name" value="Aminopeptidase N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000016">
        <property type="entry name" value="Glutamyl aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034016">
        <property type="entry name" value="M1_APN-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF253">
        <property type="entry name" value="AMINOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="23" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="17" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="18" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="11 23" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="19" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 21 23" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15 23" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="7 23" id="KW-0645">Protease</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 24" id="KW-0732">Signal</keyword>
    <keyword evidence="13" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="12 21 23" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="24">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033751001" description="Aminopeptidase" evidence="24">
        <location>
            <begin position="22"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="27">
        <location>
            <begin position="32"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="25">
        <location>
            <begin position="266"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1-like C-terminal" evidence="26">
        <location>
            <begin position="563"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="20">
        <location>
            <position position="330"/>
        </location>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="352"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
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        <location>
            <position position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR634016-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-4"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU364040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="JAV55018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="EMBL" id="KAB0798929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="904" mass="104973" checksum="2CCCDD2055B08FB8" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1K4D0</accession>
    <name>A0A1Y1K4D0_PHOPY</name>
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        <recommendedName>
            <fullName evidence="6">SH3 domain-binding glutamic acid-rich protein homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_09454</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
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        <text evidence="1">Belongs to the SH3BGR family.</text>
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    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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    </dbReference>
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        </location>
    </feature>
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        <location>
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            <end position="249"/>
        </location>
    </feature>
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        <source>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="JAV56349.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAB0798461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="260" mass="29592" checksum="2DD7AC7EE9F6AA79" modified="2017-08-30" version="1">MGIKIYISGISGNKEVKKRQQRVLMILDSKNIKYEVVDIAEPGNEDPKEFMQNNAKSFGATIGDANPRHPLPPQIFNDEDYCGDYDQFDLSNEIDEIEKFLKLPSVHTDKTIESHAEIKLGNGEITHDPKDTPKEATEEQKSEEPKAEEVKTEDVPVEDNVDEHNSSEAAQGEVNEKNEKESEENKKEVEKNEEPEKNKEEPEVNKEETEKNKEEPEENEEVEKIKEEPEKHEVDNAKVESESKEKSEDGNELSETAAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1KD31</accession>
    <name>A0A1Y1KD31_PHOPY</name>
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        <recommendedName>
            <fullName evidence="16">Phosphatidylinositol 3-kinase regulatory subunit alpha</fullName>
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    </protein>
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        <name evidence="14" type="ORF">PPYR_05851</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
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        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
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                <person name="Al-Wathiqui N."/>
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            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01087899">
        <property type="protein sequence ID" value="JAV58408.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000003">
        <property type="protein sequence ID" value="KAB0801497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1KD31"/>
    <dbReference type="InParanoid" id="A0A1Y1KD31"/>
    <dbReference type="OrthoDB" id="3175255at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12923">
        <property type="entry name" value="iSH2_PI3K_IA_R"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RhoGAP"/>
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        <property type="entry name" value="SH2_nSH2_p85_like"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000146">
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    </dbReference>
    <dbReference type="FunFam" id="1.10.555.10:FF:000070">
        <property type="entry name" value="Phosphatidylinositol 3-kinase regulatory subunit alpha-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000100">
        <property type="entry name" value="phosphatidylinositol 3-kinase regulatory subunit gamma"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032498">
        <property type="entry name" value="PI3K_P85_iSH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035022">
        <property type="entry name" value="PI3kinase_P85_nSH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051854">
        <property type="entry name" value="Rho-type_GAP"/>
    </dbReference>
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        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
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        <property type="entry name" value="SAM/pointed_sf"/>
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        <property type="entry name" value="SH2"/>
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    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
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    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46075">
        <property type="entry name" value="CHIMERIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46075:SF5">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16454">
        <property type="entry name" value="PI3K_P85_iSH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00678">
        <property type="entry name" value="PI3KINASEP85"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
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    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="2"/>
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    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="1 6" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="SH3" evidence="9">
        <location>
            <begin position="2"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="10">
        <location>
            <begin position="103"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="11">
        <location>
            <begin position="175"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="10">
        <location>
            <begin position="256"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="12">
        <location>
            <begin position="324"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="8">
        <location>
            <begin position="559"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="8">
        <location>
            <begin position="845"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="739"/>
            <end position="794"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="JAV58408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAB0801497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="962" mass="109660" checksum="C8D046ACEC07FA3B" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1KJJ3</accession>
    <name>A0A1Y1KJJ3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 15">Dolichol-phosphate mannosyltransferase subunit 1</fullName>
            <ecNumber evidence="7 15">2.4.1.83</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PPYR_01196</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">1611_PpyrPB1</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">1611_PpyrPB1</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a di-trans,poly-cis-dolichyl phosphate + GDP-alpha-D-mannose = a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + GDP</text>
            <dbReference type="Rhea" id="RHEA:21184"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 15">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Component of the dolichol-phosphate mannose (DPM) synthase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 15">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 15">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.83" evidence="7 15"/>
    <dbReference type="EMBL" id="GEZM01081549">
        <property type="protein sequence ID" value="JAV61602.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1KJJ3"/>
    <dbReference type="FunCoup" id="A0A1Y1KJJ3">
        <property type="interactions" value="1567"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1KJJ3"/>
    <dbReference type="OrthoDB" id="2603at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004582">
        <property type="term" value="F:dolichyl-phosphate beta-D-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035269">
        <property type="term" value="P:protein O-linked glycosylation via mannose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06442">
        <property type="entry name" value="DPM1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000036">
        <property type="entry name" value="Dolichol-phosphate mannosyltransferase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039528">
        <property type="entry name" value="DPM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43398">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43398:SF1">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 15" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 15" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0464">Manganese</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="16">
        <location>
            <begin position="12"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00014858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU365083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="JAV61602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAB0804226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="244" mass="27457" checksum="CBD539422A47BA38" modified="2017-08-30" version="1">MSSSTKSQNKYSILLPTYNEVENLPIIIWLIVKCMEKSGYGYEIIIIDDGSPDGTLEAGEQLQKIYGSSKIVLRPREKKLGLGTAYIHGIKHATGNFIIIMDADLSHHPKYIPEFIQQQEIHNYDIVTGTRYLGNGGVHGWDFKRKLISRGANFLTQLLLRPGVSDLTGSFRLYKKDVLQTLIQSCISKGYVFQMEMIVRARQCHFTIGEVPIAFVDRVYGESKLGGSEIVQFATGLLYLFVTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1KNI6</accession>
    <name>A0A1Y1KNI6_PHOPY</name>
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        <recommendedName>
            <fullName evidence="5">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="7" type="ORF">PPYR_08430</name>
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    <organism evidence="6">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01080833">
        <property type="protein sequence ID" value="JAV62031.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1KNI6"/>
    <dbReference type="InParanoid" id="A0A1Y1KNI6"/>
    <dbReference type="OrthoDB" id="114727at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000035">
        <property type="entry name" value="Calcium and integrin-binding family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051433">
        <property type="entry name" value="CIBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45791:SF1">
        <property type="entry name" value="CALCIUM AND INTEGRIN BINDING FAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45791">
        <property type="entry name" value="CALCIUM AND INTEGRIN BINDING FAMILY MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="99"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="141"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="JAV62031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0797436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="184" mass="20853" checksum="ED8717152394FF89" modified="2017-08-30" version="1">MGQSKSQFSEEELQDYEDLTYFTKKEVLYAHQKFKALAPEKVGHNKNAKLPMSKILQYPELGVNPFGDRICKVFSSSHDGDCTFEDFLDMMSVFSDAAPKAVKAEHAFRIFDFDGDDMIGTSDLQQVVDRLIGSNHLSEAEMQHLIQKILEEADLDDDGALSFAEFEHIIDKSSDFASAFRIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1KSF3</accession>
    <name>A0A1Y1KSF3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Schwannomin interacting protein 1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_09417</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01077942">
        <property type="protein sequence ID" value="JAV63130.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1KSF3"/>
    <dbReference type="InParanoid" id="A0A1Y1KSF3"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030054">
        <property type="term" value="C:cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035332">
        <property type="term" value="P:positive regulation of hippo signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039045">
        <property type="entry name" value="SCHIP_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015649">
        <property type="entry name" value="SCHIP_1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13103:SF2">
        <property type="entry name" value="IQCJ-SCHIP1 READTHROUGH TRANSCRIPT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13103">
        <property type="entry name" value="SCHWANNOMIN INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10148">
        <property type="entry name" value="SCHIP-1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="12"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="JAV63130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0798424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="298" mass="34336" checksum="96399D4DF971578D" modified="2017-08-30" version="1">MDFAAQSVRTKRRTDREEIRRRLAMGSEDDYYNDRPGRKPSLQARLQSGMNLQICFMNETASDTDSPSSDSECPMTNPKEQRMSPKIIKTAPVHPELVLEPSLPIRPATLAIGQPLLQPVTEHMTETDFFTRQARLQTEARMALAQAKEMARMQMEIERQRQIKSPITEMVRHSLEKVGIPFPEERRRLSRQILTEMNVAQLQVIVNDLHTQIETLNEVLVKFLMERDDLHMEQDSMLVDIEDLTRYLGAKEQRLKEKSIIQNNNITPFSTSPPRSPLAALNSSVKPHLHRIANFVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1L2W8</accession>
    <name>A0A1Y1L2W8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Luciferin 4-monooxygenase</fullName>
            <ecNumber evidence="3">1.13.12.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PPYR_07006</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">1611_PpyrPB1</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">1611_PpyrPB1</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>firefly D-luciferin + ATP + O2 = firefly oxyluciferin + hnu + AMP + CO2 + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:10732"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16792"/>
            <dbReference type="ChEBI" id="CHEBI:30212"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58038"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="1.13.12.7"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EC" id="1.13.12.7" evidence="3"/>
    <dbReference type="EMBL" id="GEZM01071260">
        <property type="protein sequence ID" value="JAV65924.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01071259">
        <property type="protein sequence ID" value="JAV65925.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01071258">
        <property type="protein sequence ID" value="JAV65926.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01071256">
        <property type="protein sequence ID" value="JAV65928.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A1Y1L2W8"/>
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    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047077">
        <property type="term" value="F:Photinus-luciferin 4-monooxygenase (ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008218">
        <property type="term" value="P:bioluminescence"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046949">
        <property type="term" value="P:fatty-acyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Firefly_Luc_like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="4-coumarate--CoA ligase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Long-chain-fatty-acid--CoA ligase FadD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF394">
        <property type="entry name" value="LUCIFERIN 4-MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0455">Luminescence</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="12" id="KW-0599">Photoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="14">
        <location>
            <begin position="68"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="15">
        <location>
            <begin position="485"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="JAV65926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAB0799126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="573" mass="63347" checksum="1971BB823AB2AED3" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1L5E9</accession>
    <name>A0A1Y1L5E9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ADF-H domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_09087</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the actin-binding proteins ADF family. GMF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01063920">
        <property type="protein sequence ID" value="JAV68909.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="FunCoup" id="A0A1Y1L5E9">
        <property type="interactions" value="380"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1L5E9"/>
    <dbReference type="OrthoDB" id="3919494at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071933">
        <property type="term" value="F:Arp2/3 complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071846">
        <property type="term" value="P:actin filament debranching"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034316">
        <property type="term" value="P:negative regulation of Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11283">
        <property type="entry name" value="ADF_GMF-beta_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000026">
        <property type="entry name" value="Glia maturation factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011171">
        <property type="entry name" value="GMF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11249:SF2">
        <property type="entry name" value="GLIA MATURATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11249">
        <property type="entry name" value="GLIAL FACTOR NATURATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001788">
        <property type="entry name" value="GMF-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADF-H" evidence="7">
        <location>
            <begin position="7"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR001788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="JAV68909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0798094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="144" mass="16772" checksum="F5FCF0E3C45F12DA" modified="2017-08-30" version="1">MMSNSNGVNICSIGEDVKKTLEEFRFRKEQDTTAVILKVDREKQEILIDDIMESTDIEGIQEALPSHQPRYIIVSYKHNHSDGRISFPLCFIFYTPRDSHAELQMLYAGSKISLQKQCSLTRSYDIRELEELTEEWLLEKLGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1L5T7</accession>
    <name>A0A1Y1L5T7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_06537</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
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    <reference evidence="7" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
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        </source>
    </reference>
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        <property type="protein sequence ID" value="JAV69038.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
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        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KAB0800798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="PANTHER" id="PTHR46708:SF11">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE ETA-LIKE"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="6"/>
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        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="5"/>
    </dbReference>
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        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
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    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011907343" description="Fibronectin type-III domain-containing protein" evidence="4">
        <location>
            <begin position="28"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="862"/>
            <end position="882"/>
        </location>
    </feature>
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        <location>
            <begin position="247"/>
            <end position="355"/>
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    </feature>
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        <location>
            <begin position="564"/>
            <end position="666"/>
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    </feature>
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        <location>
            <begin position="670"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="5">
        <location>
            <begin position="759"/>
            <end position="861"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="948"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="948"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="963"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="978"/>
            <end position="1001"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="JAV69039.1"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAB0800798.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
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    </evidence>
    <sequence length="1180" mass="133285" checksum="95D72E15C0B276D0" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1L923</accession>
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        <recommendedName>
            <fullName evidence="24">Aminopeptidase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="29" type="ORF">PPYR_06158</name>
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    <organism evidence="28">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="28" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
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            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="29 30" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="29">1611_PpyrPB1</strain>
            <tissue evidence="29">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="29" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="29">1611_PpyrPB1</strain>
            <tissue evidence="29">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal amino acid, Xaa-|-Yaa- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide.</text>
            <dbReference type="EC" id="3.4.11.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="22 24">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="22 24">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 24">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-" evidence="24"/>
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        <property type="protein sequence ID" value="JAV70094.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000004">
        <property type="protein sequence ID" value="KAB0800418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="510539at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016285">
        <property type="term" value="F:alanyl aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="M1_APN-Q_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.50.20:FF:000001">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1910:FF:000008">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1730:FF:000012">
        <property type="entry name" value="Aminopeptidase N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
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        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034016">
        <property type="entry name" value="M1_APN-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF294">
        <property type="entry name" value="THYROTROPIN-RELEASING HORMONE-DEGRADING ECTOENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 24" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="18" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="19" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="12 24" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="20" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="17 24" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 22 24" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16 24" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="8 24" id="KW-0645">Protease</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="14" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="9 24" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15 24" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="13 22 24" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="27">
        <location>
            <begin position="115"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="25">
        <location>
            <begin position="333"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1-like C-terminal" evidence="26">
        <location>
            <begin position="636"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="21">
        <location>
            <position position="406"/>
        </location>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="405"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="409"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="428"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="23">
        <location>
            <position position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="RuleBase" id="RU364040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EMBL" id="JAV70094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="EMBL" id="KAB0800418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="993" mass="114323" checksum="4C56DFEF620BA240" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LBL7</accession>
    <name>A0A1Y1LBL7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Endothelin-converting enzyme 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PPYR_07357</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M13 family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01062408">
        <property type="protein sequence ID" value="JAV69740.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1LBL7"/>
    <dbReference type="FunCoup" id="A0A1Y1LBL7">
        <property type="interactions" value="34"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1LBL7"/>
    <dbReference type="OrthoDB" id="6475849at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08662">
        <property type="entry name" value="M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF133">
        <property type="entry name" value="PHOSPHATE-REGULATING NEUTRAL ENDOPEPTIDASE PHEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00786">
        <property type="entry name" value="NEPRILYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="12">
        <location>
            <begin position="103"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="11">
        <location>
            <begin position="590"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="262"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="JAV69740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAB0799477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="797" mass="91152" checksum="E57A535DF207CD46" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LFL2</accession>
    <name>A0A1Y1LFL2_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Zinc transporter 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PPYR_12587</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">1611_PpyrPB1</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">1611_PpyrPB1</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Zn(2+)(in) + 2 H(+)(out) = Zn(2+)(out) + 2 H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:72627"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Secretory vesicle membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01057118">
        <property type="protein sequence ID" value="JAV72439.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0792967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1LFL2"/>
    <dbReference type="FunCoup" id="A0A1Y1LFL2">
        <property type="interactions" value="26"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1LFL2"/>
    <dbReference type="OrthoDB" id="9944568at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="CATION EFFLUX PROTEIN/ ZINC TRANSPORTER"/>
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    </dbReference>
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        <property type="entry name" value="RE54080P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
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        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
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        <location>
            <begin position="119"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="149"/>
            <end position="176"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="230"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="14">
        <location>
            <begin position="87"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein cytoplasmic" evidence="15">
        <location>
            <begin position="295"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004638"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022906"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
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        </source>
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            <dbReference type="ARBA" id="ARBA00023329"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00048349"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="JAV72439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAB0792967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="19">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="385" mass="42754" checksum="E8478322FF623ECB" modified="2017-08-30" version="1">MFYSFQDGGNYGTIPYSITGTPKRVIYCVHGKPSAGCCRVLEGEISESGELNAISHARENSDTTNLVNKHCHQVRSEKVDKRARRKLIVASVLCVIFMIGEALGGYISSSLAIATDAAHLLTDFASFMISLFSLWVATRPATKKMSFGWYRAEVIGALTSVLMIWVVTGVLVYLAVERLIEKNFDIDAKVMLITSGIGVIVNIIMGLTLHQHGHSHGGHAGHSHNENINVRAAFIHVLGDFLQSFGVFVAALVIYFKPDWDIIDPICTFLFSILVLLTTFTIIKDTLLVLMEGMPKGIDFNEVMSIILNIEGVERVHNLRIWALSLDKIALSSHIAIRPGVNPQSILMVATKCIHDKYNFFEMTLQIEEFQEIMENCHQCRGPAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LGY5</accession>
    <name>A0A1Y1LGY5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Amino acid transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_09676</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01055884">
        <property type="protein sequence ID" value="JAV72894.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01055883">
        <property type="protein sequence ID" value="JAV72895.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1LGY5"/>
    <dbReference type="FunCoup" id="A0A1Y1LGY5">
        <property type="interactions" value="98"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1LGY5"/>
    <dbReference type="OrthoDB" id="5877963at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015501">
        <property type="term" value="F:glutamate:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005313">
        <property type="term" value="F:L-glutamate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015175">
        <property type="term" value="F:neutral L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3860.10">
        <property type="entry name" value="Sodium:dicarboxylate symporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050746">
        <property type="entry name" value="DAACS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001991">
        <property type="entry name" value="Na-dicarboxylate_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036458">
        <property type="entry name" value="Na:dicarbo_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11958:SF63">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11958">
        <property type="entry name" value="SODIUM/DICARBOXYLATE SYMPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00375">
        <property type="entry name" value="SDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00173">
        <property type="entry name" value="EDTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118215">
        <property type="entry name" value="Proton glutamate symport protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0769">Symport</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="273"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="JAV72894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0798683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="486" mass="52920" checksum="C4899C7E0DDE258A" modified="2017-08-30" version="1">MAQSRMRCLNRHSLLTLLTVIGVIGGTVTGLVLNQFRSREWTKREIMYVKYPGDLFLRVLKSLIIPLLTSSIVSAIGSLDLSLSKKIAARSIIYYTVTTFCAVVLGIVLVTTIRPGVGIERSAQKKKVDAKIVLTADTLMDLGRNMFPPNIIEATVGQTHIHIKVPKEHEENPRFKNDTYNLRDEYPFWDFEEVLELRSTNILGLVVYSIIIGIAVGQMGQRGAPLVIFFDSLSKAMMIVTGWIIWLSPIGVFFLVVAQIMEIDNFATLLAQLGFYFGTVLLGLFIHGLCTLTVVYFLCTRTLPFKTIGGLTQALATAFGTASSSATMPISIQALDDIGVDPRVTRFVIPIGAMCNLDGTALYEAVAAIFIAQRNAIPLGFGHTVAVCLTATAASIGGAGIPQAGLVTMVMVLDTVGLPADQISLILAVDWLLDRFRTTINVMGDCLGARIVDILSKNDLKGIPETDKLNAADHELVEIIKDDCIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LKW9</accession>
    <name>A0A1Y1LKW9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sulfatase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PPYR_02934</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
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                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
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                <person name="Oba Y."/>
                <person name="Weng J.K."/>
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        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
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    </dbReference>
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        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00884">
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            <end position="535"/>
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            <begin position="23"/>
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            <dbReference type="ARBA" id="ARBA00001913"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00884"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="JAV71657.1"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAB0791134.1"/>
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        <source>
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</entry>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
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                <person name="Al-Wathiqui N."/>
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            <dbReference type="DOI" id="10.1038/srep38556"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
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    <reference evidence="3" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
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    <dbReference type="Proteomes" id="UP000327044">
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        <property type="entry name" value="FBOX"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="33"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="JAV73565.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0800649.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
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        <recommendedName>
            <fullName evidence="5">BTB domain-containing protein</fullName>
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            <taxon>Insecta</taxon>
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            <taxon>Neoptera</taxon>
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            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
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        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
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            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
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            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
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    <reference evidence="7" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the KCTD3 family.</text>
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        <property type="protein sequence ID" value="JAV72787.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
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        <property type="protein sequence ID" value="KAB0795671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A1Y1LP61"/>
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    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="WD40_repeat_dom_sf"/>
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        <property type="entry name" value="WD40_rpt"/>
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        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR15859">
        <property type="entry name" value="SETA BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
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        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <feature type="domain" description="BTB" evidence="5">
        <location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="JAV72787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0795671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="692" mass="76394" checksum="3EC3495D7A7BC010" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LQY7</accession>
    <name>A0A1Y1LQY7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ribonuclease III</fullName>
            <ecNumber evidence="5">3.1.26.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="29" type="ORF">PPYR_09291</name>
    </gene>
    <organism evidence="28">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="28" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="29 30" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="29">1611_PpyrPB1</strain>
            <tissue evidence="29">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="29" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="29">1611_PpyrPB1</strain>
            <tissue evidence="29">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="20">Belongs to the helicase family. Dicer subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.3" evidence="5"/>
    <dbReference type="EMBL" id="GEZM01049152">
        <property type="protein sequence ID" value="JAV76069.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A1Y1LQY7">
        <property type="interactions" value="838"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1LQY7"/>
    <dbReference type="OrthoDB" id="2392202at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070578">
        <property type="term" value="C:RISC-loading complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004530">
        <property type="term" value="F:deoxyribonuclease I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006309">
        <property type="term" value="P:apoptotic DNA fragmentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016441">
        <property type="term" value="P:post-transcriptional gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031054">
        <property type="term" value="P:pre-miRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15903">
        <property type="entry name" value="Dicer_PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10843">
        <property type="entry name" value="DSRM_DICER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02843">
        <property type="entry name" value="PAZ_dicer_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000015">
        <property type="entry name" value="endoribonuclease Dicer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1520.10:FF:000005">
        <property type="entry name" value="Putative endoribonuclease dicer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.260.10:FF:000002">
        <property type="entry name" value="Putative Endoribonuclease Dicer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.380">
        <property type="entry name" value="Dicer dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038248">
        <property type="entry name" value="Dicer_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005034">
        <property type="entry name" value="Dicer_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044441">
        <property type="entry name" value="DICER_DSRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048513">
        <property type="entry name" value="Dicer_PBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048512">
        <property type="entry name" value="Dicer_platform"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14950">
        <property type="entry name" value="DICER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14950:SF37">
        <property type="entry name" value="ENDORIBONUCLEASE DICER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03368">
        <property type="entry name" value="Dicer_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20932">
        <property type="entry name" value="Dicer_dsRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20930">
        <property type="entry name" value="Dicer_PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20931">
        <property type="entry name" value="Dicer_platform"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02170">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00636">
        <property type="entry name" value="Ribonuclease_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00949">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51327">
        <property type="entry name" value="DICER_DSRBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50821">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00517">
        <property type="entry name" value="RNASE_3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="14" id="KW-0347">Helicase</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="19" id="KW-0464">Manganese</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="17 21" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="18" id="KW-0943">RNA-mediated gene silencing</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="26">
        <location>
            <begin position="409"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="domain" description="Dicer dsRNA-binding fold" evidence="27">
        <location>
            <begin position="603"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="domain" description="PAZ" evidence="25">
        <location>
            <begin position="873"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="domain" description="RNase III" evidence="24">
        <location>
            <begin position="1310"/>
            <end position="1511"/>
        </location>
    </feature>
    <feature type="domain" description="RNase III" evidence="24">
        <location>
            <begin position="1563"/>
            <end position="1720"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="23">
        <location>
            <begin position="1745"/>
            <end position="1811"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="377"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00035116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS51327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EMBL" id="JAV76069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="EMBL" id="KAB0798298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1818" mass="206861" checksum="5481FC4DE418B3EF" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LS11</accession>
    <name>A0A1Y1LS11_PHOPY</name>
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        <recommendedName>
            <fullName evidence="6">Annexin</fullName>
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    <organism evidence="7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="domain">
        <text evidence="6">A pair of annexin repeats may form one binding site for calcium and phospholipid.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the annexin family.</text>
    </comment>
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        <property type="protein sequence ID" value="JAV74675.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KAB0796388.1"/>
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        <property type="term" value="C:cytoplasm"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:phosphatidylserine binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:endosome transport via multivesicular body sorting pathway"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAB0796388.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="324" mass="36161" checksum="F6F448E7A9789E62" modified="2017-08-30" version="1">MSTTAQYYPFKCTPTVYPADPFDPVADAATLRKAMKGFGTDEKSIIDVLARRGIVQRLEIAETFKTSYGKDLISELKSELGGKFEDVIIALMTPLPQFYAKELHDAVAGLGTDEEAIIEILCTLSNYGIRTIAQFYEQMYNTTLEKDLKDDTSGHFKRLLVSLVQGNRDENQGVNEAQAVADADHLFKAGEAKWGTDESEFNVILVTRSYQQLRQVFAEYERLSGKDIEEAIKKEFSGYVQKGLLGIVKCVKSKVGYFAERLHDAMAGLGTKDKTLIRIIVSRSEIDLADIKQAFVDKYGKSLESWITGDTSGDYKRVLLAIVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LT71</accession>
    <name>A0A1Y1LT71_PHOPY</name>
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    <reference evidence="1" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
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                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
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            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
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                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
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    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAB0799228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="280" mass="32559" checksum="87A50873F21AD920" modified="2017-08-30" version="1">MSQLEIKKMKQGMSYSCKEKTIILNVFKYFRINFPEKCVTDIVRRTSKATGCSEKSIFQFRKEEASVEGFKEPSKTKIRKNININSRDIKYDNNVRQTIRNIIYDLKYRNIVPSLNTILKHVNADNHLPNFSLMTLRRLMFDMGFYYEKNGNKSILAEKTVKQENNLTMRGSSKIPEGENVLQKVAPIPHVQCTVPTNHLQPPINQHLNERVIPMAIHVHENHIIPPVHAPVPHGVPVMLNHRKELMPLHHHGMIPSNMDPHLKRDMPPWMNSHNVIKQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LXL1</accession>
    <name>A0A1Y1LXL1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PABS domain-containing protein</fullName>
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    <gene>
        <name evidence="6" type="ORF">PPYR_03324</name>
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    <organism evidence="5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
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        <lineage>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
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            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
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                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the spermidine/spermine synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01046580">
        <property type="protein sequence ID" value="JAV77050.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1LXL1"/>
    <dbReference type="FunCoup" id="A0A1Y1LXL1">
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            <dbReference type="EMBL" id="JAV77050.1"/>
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        <source>
            <dbReference type="EMBL" id="KAB0791524.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
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    <sequence length="416" mass="47561" checksum="B20512F3A24E2231" modified="2017-08-30" version="1">MEKLQRATDNTVKVKSDICLILWLRSKNRFLRPSLFPNRPVIPVKKPEMSVYTLLLDFSVDPKNVKNESHLSLLSSNIENVLRDYIGNLKLITTLSIAGGSLNIYSGDMGSVISLRIFDNGTITVNIEYLKGDDSDINILTLEKYRKMEHNLRGCGILNDTRYPPIHRGTFSRYFVSSDDRLLEYDIDSILFEERSPYQKVQVVHSKSLGNMLVLDDLQNISEADLIYTETLMLRGKEDYKDKEIVILGGGDGALLYELLKEQPKHVTMLEIDEVVMRACKQHMRSICGDVLDQKSTSNYQIIVGDCMKSLDQFVKEDRKFDYVFGDLTDVPIADDSESEIWNFVKKYLSLSFKILKPTGKFMSHGNGACCSLALEKYENYLATIDPPLVVNKCQAFIPSFMEFWVFYQIHFANKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LXV7</accession>
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        <recommendedName>
            <fullName evidence="14">SUN domain-containing protein</fullName>
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    </protein>
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        <name evidence="16" type="ORF">PPYR_08428</name>
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    <organism evidence="15">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
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            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
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            <taxon>Lampyrinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">1611_PpyrPB1</strain>
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        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">1611_PpyrPB1</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="10">Interacts with EMP65.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
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            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the SLP1 family.</text>
    </comment>
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        <property type="protein sequence ID" value="JAV78329.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MEMBRANE PROTEIN CH1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12953:SF0">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="837"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="domain" description="SUN" evidence="14">
        <location>
            <begin position="237"/>
            <end position="396"/>
        </location>
    </feature>
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        <location>
            <begin position="33"/>
            <end position="75"/>
        </location>
    </feature>
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        <location>
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            <end position="255"/>
        </location>
    </feature>
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        <location>
            <begin position="658"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="703"/>
            <end position="743"/>
        </location>
    </feature>
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        <location>
            <begin position="760"/>
            <end position="823"/>
        </location>
    </feature>
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        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="225"/>
            <end position="236"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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            <end position="682"/>
        </location>
    </feature>
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        </location>
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    </evidence>
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        <source>
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    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51469"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="JAV78329.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAB0797434.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1116" mass="124244" checksum="D8E524EB7763D011" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1M2K0</accession>
    <name>A0A1Y1M2K0_PHOPY</name>
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        </recommendedName>
        <alternativeName>
            <fullName evidence="7">X-Pro-Lys N-terminal protein methyltransferase 1</fullName>
        </alternativeName>
    </protein>
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        <name evidence="13" type="ORF">PPYR_08507</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
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            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
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                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N-terminal L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine = N-terminal N,N,N-trimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:54712"/>
            <dbReference type="Rhea" id="RHEA-COMP:13785"/>
            <dbReference type="Rhea" id="RHEA-COMP:13971"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:138057"/>
            <dbReference type="ChEBI" id="CHEBI:138315"/>
            <dbReference type="EC" id="2.1.1.244"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N-terminal L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-methionine = N-terminal N,N-dimethyl-L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:54736"/>
            <dbReference type="Rhea" id="RHEA-COMP:13787"/>
            <dbReference type="Rhea" id="RHEA-COMP:13974"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:138059"/>
            <dbReference type="ChEBI" id="CHEBI:138318"/>
            <dbReference type="EC" id="2.1.1.244"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N-terminal L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine = N-terminal N,N,N-trimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:54724"/>
            <dbReference type="Rhea" id="RHEA-COMP:13789"/>
            <dbReference type="Rhea" id="RHEA-COMP:13973"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:138061"/>
            <dbReference type="ChEBI" id="CHEBI:138317"/>
            <dbReference type="EC" id="2.1.1.244"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. NTM1 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.244" evidence="5"/>
    <dbReference type="EMBL" id="GEZM01041969">
        <property type="protein sequence ID" value="JAV80084.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1M2K0"/>
    <dbReference type="FunCoup" id="A0A1Y1M2K0">
        <property type="interactions" value="1695"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1M2K0"/>
    <dbReference type="OrthoDB" id="1298661at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071885">
        <property type="term" value="F:N-terminal protein N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000025">
        <property type="entry name" value="N-terminal Xaa-Pro-Lys N-methyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008576">
        <property type="entry name" value="MeTrfase_NTM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12753">
        <property type="entry name" value="AD-003 - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12753:SF0">
        <property type="entry name" value="ALPHA N-TERMINAL PROTEIN METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05891">
        <property type="entry name" value="Methyltransf_PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016958">
        <property type="entry name" value="DUF858_MeTrfase_lik"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="11">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="115"/>
            <end position="116"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00043129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR016958-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="JAV80084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAB0797514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="241" mass="27313" checksum="8ED6930C9C1AC2D6" modified="2017-08-30" version="1">MNKPIHKFYSDAEEYWSKIPPTIDGMLGGFGHISQVDVQTSKIFLQQLFKSKDPPGRTYAADCGAGIGRISKHLLLNIFDKVDLIEQNEIFLDRARDYLGPKLISKVGSFVPVALQNFKAESNKYDIIWIQWVLGHLTDAHCIQFFHNCINSLKPNGMIVVKENITSGQLEVDEKDSSVTRPIHELKCLFKESGLDCYRQMKQSSFPKELYNVYMFALKPKSNLEINTDLPATNVNLVAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1M640</accession>
    <name>A0A1Y1M640_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">E3 ubiquitin-protein ligase NRDP1</fullName>
            <ecNumber evidence="3">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">RING finger protein 41</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">RING-type E3 ubiquitin transferase NRDP1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PPYR_15314</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">1611_PpyrPB1</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">1611_PpyrPB1</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="3"/>
    <dbReference type="EMBL" id="GEZM01040036">
        <property type="protein sequence ID" value="JAV80981.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01040034">
        <property type="protein sequence ID" value="JAV80983.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000761">
        <property type="protein sequence ID" value="KAB0790804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1M640"/>
    <dbReference type="FunCoup" id="A0A1Y1M640">
        <property type="interactions" value="1076"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1M640"/>
    <dbReference type="OrthoDB" id="1630758at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043122">
        <property type="term" value="P:regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16634">
        <property type="entry name" value="mRING-HC-C3HC3D_Nrdp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015036">
        <property type="entry name" value="NRDP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037255">
        <property type="entry name" value="NRDP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10131:SF157">
        <property type="entry name" value="RECEPTOR-ASSOCIATED FACTOR, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10131">
        <property type="entry name" value="TNF RECEPTOR ASSOCIATED FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08941">
        <property type="entry name" value="USP8_interact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160088">
        <property type="entry name" value="NRDP1 C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="14">
        <location>
            <begin position="18"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="135"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="JAV80981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAB0790804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="315" mass="36511" checksum="FC88FAC52066A637" modified="2017-08-30" version="1">MGFELTRFQGDVDEELVCPICSGVLEDPLQAPVCEHAFCRACIQEWICRQPNCPVDRQHITTVQLRPVPRILRNLLSRLCINCDNAEYGCTRVLKLDTLATHLEECEHNPKRLIPCEQGCGLVIPKDELKDHNCIKELRALVHTQQQKLNDFQQELAEQRFTMVEQKRELQLLKDFMKAMRISNPAMRAIADQMERDEVLRWSNTLARARVTRWGGMISTPDEILQRMIKRTLSESGCPAHIIDDLMENCHERRWPPGLCSLETRQTNRRLYENYVCKRIPGKQAVLVLHCDNEHMSEEMMVEPGLVMIFAHGIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1M923</accession>
    <name>A0A1Y1M923_PHOPY</name>
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            <fullName evidence="6">Uncharacterized protein</fullName>
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        <name evidence="7" type="ORF">PPYR_08603</name>
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    <organism evidence="6">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
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        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Stress granule</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MCRIP family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01042484">
        <property type="protein sequence ID" value="JAV79827.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029428">
        <property type="entry name" value="MCRIP"/>
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        <property type="entry name" value="FAM195"/>
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    </dbReference>
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    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="JAV79827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0797610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="147" mass="17107" checksum="A6E2AA1599BB3D2A" modified="2017-08-30" version="1">MYNIKGPSKMVAKSARRGISQNVDNFKHCKSLDNNDNELINVSKPVFHNTCKRNILNKQEQSMRITPQHEEIINYIQDSWTLVRSDLDETCSKKTNNNCDGNCTVLFYEDDPCPHLQDFKPFDLENWWGKRLFHSITNSINGKVDKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1MB85</accession>
    <name>A0A1Y1MB85_PHOPY</name>
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            <fullName evidence="2">Galectin</fullName>
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        <name evidence="7" type="ORF">PPYR_00974</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
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            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
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                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01035964">
        <property type="protein sequence ID" value="JAV83079.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KAB0804004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1MB85"/>
    <dbReference type="InParanoid" id="A0A1Y1MB85"/>
    <dbReference type="OrthoDB" id="6770721at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="F:galactoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044156">
        <property type="entry name" value="Galectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001079">
        <property type="entry name" value="Galectin_CRD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11346:SF176">
        <property type="entry name" value="32 KDA BETA-GALACTOSIDE-BINDING LECTIN LEC-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11346">
        <property type="entry name" value="GALECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00337">
        <property type="entry name" value="Gal-bind_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00908">
        <property type="entry name" value="Gal-bind_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Galectin" evidence="5">
        <location>
            <begin position="12"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="165"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU102079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="JAV83079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0804004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="242" mass="26387" checksum="D3A9FEEA976E3621" modified="2017-08-30" version="1">MEQPIIDPPIPLVGPIGGRFSPGKVIRIKGAVPSIANRFDINLQCGPQTAPRDDIVLQIAVRILDGFIALNSLQNGIWDDELKGHTQPIKRADHFEMVIVCDFNKFMVSINDQLVCDYPQRIHYDRITHLVIEGEVTVAEISDGSQASGKPPSYSEVVNVPPYPQDLSATSPPTHNSATVTVTSDSSPTAPELIPLTGAELNAPLSKPDKKSEPMGRVGIFVFFLVNIILGILLLTWVMFNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1MEW1</accession>
    <name>A0A1Y1MEW1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein phosphatase PP2A regulatory subunit A</fullName>
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    <gene>
        <name evidence="7" type="ORF">PPYR_07547</name>
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    <organism evidence="6">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
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        <lineage>
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            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
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    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the phosphatase 2A regulatory subunit A family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01033297">
        <property type="protein sequence ID" value="JAV84274.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1MEW1"/>
    <dbReference type="FunCoup" id="A0A1Y1MEW1">
        <property type="interactions" value="808"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1MEW1"/>
    <dbReference type="OrthoDB" id="340346at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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</entry>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
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                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
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            <dbReference type="PubMed" id="30324905"/>
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        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
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                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
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        </source>
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    </evidence>
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</entry>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
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                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
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                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
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                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
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                <person name="Schmitz R.J."/>
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                <person name="Shigenobu S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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                <person name="Fallon T.R."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </reference>
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            <end position="74"/>
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        <location>
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        <location>
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        <location>
            <begin position="295"/>
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        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="5"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
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    <feature type="binding site" evidence="8">
        <location>
            <position position="8"/>
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        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
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    <feature type="binding site" evidence="8">
        <location>
            <position position="47"/>
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            <position position="50"/>
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        <ligand>
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            <dbReference type="EMBL" id="JAV88608.1"/>
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        <source>
            <dbReference type="EMBL" id="KAB0799643.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
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    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="328" mass="37280" checksum="02AEA86687A96FBF" modified="2017-08-30" version="1">MDNICRTCLKVSDNLTSIFEDALLSYKIGIISSVKVSADDDLPSTICELCIRNVHLLYDFRNVIITSNATLLKRRGSLPERNNEVVIKCESNVLEQTTDEYIKLDCIDSEFDDEMPELQKPYVQKAIMKAEERKLSGQKIKESRKKRPVKKPVPHSVCNVCGVTIRSDNLNKHILIHIEDPVNCTVCGKTCKNSESLRSHMIMHRGITYSCKICTKVYKHRGGLIAHRKRHAAGGAKTVPCSICGKLFYDKQVLQKHIRSHTGERPYPCKYCNKGFSSLYARNTHTRQHTNERPYACQFCGAAFHQKVSLKTHFQSKHPTEVDALNSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1MY02</accession>
    <name>A0A1Y1MY02_PHOPY</name>
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        <recommendedName>
            <fullName evidence="13">RNA-binding protein 15B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PPYR_00834</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
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            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
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    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
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        </source>
    </reference>
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        <text evidence="2">Belongs to the RRM Spen family.</text>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="entry name" value="RNA RECOGNITION MOTIF-CONTAINING"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="287"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="368"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="SPOC" evidence="9">
        <location>
            <begin position="560"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
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            <begin position="230"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="434"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="485"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
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        <location>
            <begin position="37"/>
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        </location>
    </feature>
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        <location>
            <begin position="517"/>
            <end position="532"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="JAV90534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0803864.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="729" mass="83348" checksum="F643B0A18638AEAC" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1MYP0</accession>
    <name>A0A1Y1MYP0_PHOPY</name>
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        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_13869</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
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                <person name="Debat H.J."/>
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                <person name="Schmitz R.J."/>
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                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
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            <text>a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29091"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="7.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the complex I 30 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01001945">
        <property type="protein sequence ID" value="JAV97444.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1NHT9"/>
    <dbReference type="FunCoup" id="A0A1Y1NHT9">
        <property type="interactions" value="1185"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1NHT9"/>
    <dbReference type="OrthoDB" id="37721at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.80:FF:000002">
        <property type="entry name" value="NADH dehydrogenase iron-sulfur protein 3, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.80">
        <property type="entry name" value="NADH:ubiquinone oxidoreductase, 30kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01357">
        <property type="entry name" value="NDH1_NuoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010218">
        <property type="entry name" value="NADH_DH_suC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037232">
        <property type="entry name" value="NADH_quin_OxRdtase_su_C/D-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001268">
        <property type="entry name" value="NADH_UbQ_OxRdtase_30kDa_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020396">
        <property type="entry name" value="NADH_UbQ_OxRdtase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01961">
        <property type="entry name" value="NuoC_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004733">
        <property type="entry name" value="PRK06074.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10884:SF14">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10884">
        <property type="entry name" value="NADH DEHYDROGENASE UBIQUINONE IRON-SULFUR PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00329">
        <property type="entry name" value="Complex1_30kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143243">
        <property type="entry name" value="Nqo5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00542">
        <property type="entry name" value="COMPLEX1_30K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0520">NAD</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="NADH:ubiquinone oxidoreductase 30kDa subunit" evidence="10">
        <location>
            <begin position="86"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="JAV97444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAB0796649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="257" mass="29993" checksum="319F871B92BBA6CD" modified="2017-08-30" version="1">MASLLRQVAKAIRNPQIYNQVGANIGRGFSTGTVRLEKVETRPTVRKYNPLLKTQLTEFGQYVAECLPKYIQKVQIAAGDELELLIAPEGVLPVMQFLKDHHNAQFASLADVTALDVPSRQYRFEVVYNLLSLRYQARVRVKTYTDELTPIESIFDVYRAANWYEREVWDMYGVFFANHPDLRRILTDYGFQGHPLRKDFPLSGYVEVRYDDEQKRVVVEPLELAQEFRKFDLSAPWEQFPNFRKSHKTEEVPIDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1NNF0</accession>
    <name>A0A1Y1NNF0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">fumarate hydratase</fullName>
            <ecNumber evidence="2">4.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_08565</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.2" evidence="2"/>
    <dbReference type="EMBL" id="GEZM01000257">
        <property type="protein sequence ID" value="JAV98445.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1NNF0"/>
    <dbReference type="FunCoup" id="A0A1Y1NNF0">
        <property type="interactions" value="1389"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1NNF0"/>
    <dbReference type="OrthoDB" id="1738025at2759"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER01007"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004333">
        <property type="term" value="F:fumarate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006106">
        <property type="term" value="P:fumarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01362">
        <property type="entry name" value="Fumarase_classII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.40.30:FF:000002">
        <property type="entry name" value="Fumarate hydratase class II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.275.10:FF:000001">
        <property type="entry name" value="Fumarate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.200.10:FF:000001">
        <property type="entry name" value="Fumarate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.40.30">
        <property type="entry name" value="Fumarase/aspartase (C-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="entry name" value="Fumarase/aspartase (N-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00743">
        <property type="entry name" value="FumaraseC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005677">
        <property type="entry name" value="Fum_hydII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018951">
        <property type="entry name" value="Fumarase_C_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00979">
        <property type="entry name" value="fumC_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008909">
        <property type="entry name" value="PRK12273.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11444">
        <property type="entry name" value="ASPARTATEAMMONIA/ARGININOSUCCINATE/ADENYLOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11444:SF1">
        <property type="entry name" value="FUMARATE HYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10415">
        <property type="entry name" value="FumaraseC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00145">
        <property type="entry name" value="ARGSUCLYASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarate lyase N-terminal" evidence="4">
        <location>
            <begin position="41"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="Fumarase C C-terminal" evidence="5">
        <location>
            <begin position="439"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="JAV98445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0797572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="494" mass="53736" checksum="9F10BC5243817D52" modified="2017-08-30" version="1">MSVSQFPIYRCVPAVTRFCTRSLRSSSVMSKGFRKEKDTFGELEVPSEKYYGAQTVRSTINFNIGGETERMPYPVVTAMGILKKAAAIVNKDYGLKPEIVDAITKAADEVISGKLYHDHFPLVIWQTGSGTQSNMNTNEVISNRAIEIMGGKLGSKEPVHPNDHVNKSQSSNDTFPTAMHIAVAREIHCTLLPNLQLLHDALQQKSEEFRDIIKIGRTHTQDAVPLTLGQEFSGYVQQLQFGIERVRDTLPRLYMLALGGTAVGTGLNTRKGFAEKCATQIAQLTGLPFVSAPNKFEALAAHDAMVEVSGALNVLAVSLMKIANDIRFLASGPRCGLGELSLPENEPGSSIMPGKVNPTQCEALTMVAAQVMGNHVAVTIGGSNGHFELNVFKPMIVANVLRSIRLLGDSCKSFTEHCALGIVANKDNIRKIMEESLMLVTALNPHIGYDKAAAIAKLAHKEGSTLKQAAVKLGHVTEKQFDDWVKPEQMLGPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N3ZYM0</accession>
    <name>A0A5N3ZYM0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">TGF-beta family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PPYR_15526</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TGF-beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01001817">
        <property type="protein sequence ID" value="KAB0790149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N3ZYM0"/>
    <dbReference type="InParanoid" id="A0A5N3ZYM0"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.90.10:FF:000001">
        <property type="entry name" value="Bone morphogenetic protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001839">
        <property type="entry name" value="TGF-b_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015615">
        <property type="entry name" value="TGF-beta-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11848:SF307">
        <property type="entry name" value="BONE MORPHOGENETIC PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11848">
        <property type="entry name" value="TGF-BETA FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00019">
        <property type="entry name" value="TGF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00204">
        <property type="entry name" value="TGFB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51362">
        <property type="entry name" value="TGF_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0339">Growth factor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="TGF-beta family profile" evidence="9">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0790149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="77" mass="8613" checksum="31FA228696BCC630" modified="2020-02-26" version="1" fragment="single">AYQCTGKCFYPVAEHLSPTKHAIVQALLHSVFPSRAPRSCCVPTRLESISLLYVDDRGVLTYRFGYDDMVVAECGCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N3ZYU0</accession>
    <name>A0A5N3ZYU0_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_15454</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01001675">
        <property type="protein sequence ID" value="KAB0790208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N3ZYU0"/>
    <dbReference type="InParanoid" id="A0A5N3ZYU0"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1820">
        <property type="entry name" value="L1 transposable element, RRM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004244">
        <property type="entry name" value="Transposase_22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11505">
        <property type="entry name" value="L1 TRANSPOSABLE ELEMENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="45"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0790208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="201" mass="23082" checksum="26CBA166A666F85F" modified="2020-02-26" version="1" fragment="single">MPLTRDQISEINACVAASIKEFFQNDTFIDMIVTRVVDKINVSINDQINAAVDSVKRENVFLREKVDALEQYSRRNNIRLFGIPEEKNENIQEVVIDAFNNVGIPVTSDSIDRLHRVGKSLDSSKTRPIIIKFISYKSKHMVVTSKRKFKGTKCSIQEDLTVPRLQLLKEVQEIVGRKQTWTMDGVIFAKHKDKKFIIKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N3ZZN7</accession>
    <name>A0A5N3ZZN7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_15095</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01001191">
        <property type="protein sequence ID" value="KAB0790509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N3ZZN7"/>
    <dbReference type="InParanoid" id="A0A5N3ZZN7"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF85">
        <property type="entry name" value="GH03217P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="8">
        <location>
            <begin position="153"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0790509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="354" mass="40594" checksum="2C8BB72F16E09A6C" modified="2020-02-26" version="1">MTDQLQQQFQKFNIFMEFAIELLESSSSDESDQEIGILVDQMHKHPIPKIINYVENVVSILNDSQVGGSSLISAECHILSFLWYAGNNCTIRESGDRFNMSLSTFSSVQRRVMSFLLDLLPTVIRFPKTDLEKERVAAEFEQISGFPNILGCVDGSYINIRTPAHKIKSTYTNRHDIPSITLQGICDAKKKFLDVFTGPAGKLHDSRVFKLSFISSEIQTLSNNGHYHLIGDSAYPIRQWLLTPYRDYGNLTRQQIKYNKKLSSSRVKIENAFGLLKGRFRQLGRLDFHKVVKMAQFILCCCVLHNICIDYDDICEDIVNANEEDNAIGPDREHEMRRLGELKRQYICDLLNHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N3ZZY9</accession>
    <name>A0A5N3ZZY9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_14915</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000958">
        <property type="protein sequence ID" value="KAB0790641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N3ZZY9"/>
    <dbReference type="InParanoid" id="A0A5N3ZZY9"/>
    <dbReference type="OrthoDB" id="6261922at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041515">
        <property type="entry name" value="PPAF-2-like_Clip"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051487">
        <property type="entry name" value="Ser/Thr_Proteases_Immune/Dev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24256">
        <property type="entry name" value="TRYPTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18322">
        <property type="entry name" value="CLIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024427017" description="Peptidase S1 domain-containing protein" evidence="3">
        <location>
            <begin position="21"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="4">
        <location>
            <begin position="141"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0790641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="401" mass="44458" checksum="7BCC815310B9A43E" modified="2020-02-26" version="1">MHRVLLVGLLIVSLLIGSHSQRFSKGKSSIANTIVNTLDEISNQNDKLKMLIRSFFDYQSTSTKAPEPAEAECLCTPFYLCNNGEVNKDGSKLFEPRLAQESVNPCKTLGEICCEPLAPSPLRKKVEGIPSNFACGFGSEIPGDYYISAATTAKFGEYPWTALLLNLKYQYQCVGSLIHPEVVLTTAHCINESEKYIARVGEWNATGKTEPIAHQNMRVKSIVIHPKFVVDNLMYNAALLFLENPFKLDRNVNTACLADSSTLSYTQLQKSKCAATGWGSDVPKGVYRRVMKKIEFSLISNPSCQNQLRKTRLGKWFQLHQTFLCAIGKNGSDLCNGDGGGPLVCEISGQPLRYLQVGITSWGLDCAQNLPSVFTKVASIKHWIDQEMSARNLDTSYYTPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A142</accession>
    <name>A0A5N4A142_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_02816</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A142"/>
    <dbReference type="InParanoid" id="A0A5N4A142"/>
    <dbReference type="OrthoDB" id="66144at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861:SF1">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="32"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0791016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="272" mass="31340" checksum="FE5DB9A0ECAE0A6D" modified="2020-02-26" version="1">MNRAECFINHNHPAEREAKSAVRKLLPFVQWKKDCKVLDVGCGTGNVTHDVLQPELPVATREVIGIDRDRTVVEYANLNYGGRKLRFEQVDIVHDRKFVDAHLNYFDHIFSFSCLHFVREQGTALKHIREMLRPGGDFSFSCVTSNNFFKVVAHMAQSETWRPHIAHYENFISPYQFSQNPMGELVDFLIRAGFRVTSLAIEPREAELPLSYCPAHFISHIPIEIPADLHREFGLAVLETIRELNLSRLAQDNVEYFNAYFDGIFGHVIRPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A234</accession>
    <name>A0A5N4A234_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acyl-aliphatic-L-amino acid amidohydrolase</fullName>
            <ecNumber evidence="3">3.5.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">N-acyl-L-amino-acid amidohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PPYR_03185</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M20A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.14" evidence="3"/>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A234"/>
    <dbReference type="InParanoid" id="A0A5N4A234"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004046">
        <property type="term" value="F:aminoacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.360:FF:000005">
        <property type="entry name" value="Putative Aminoacylase-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052083">
        <property type="entry name" value="Aminoacylase-1_M20A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010159">
        <property type="entry name" value="N-acyl_aa_amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01880">
        <property type="entry name" value="Ac-peptdase-euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45892">
        <property type="entry name" value="AMINOACYLASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45892:SF1">
        <property type="entry name" value="AMINOACYLASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036696">
        <property type="entry name" value="ACY-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00758">
        <property type="entry name" value="ARGE_DAPE_CPG2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00759">
        <property type="entry name" value="ARGE_DAPE_CPG2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="12">
        <location>
            <begin position="191"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="395"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="395"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="363"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR036696-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR036696-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAB0791385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="426" mass="47183" checksum="5E0C6653F6466640" modified="2020-02-26" version="1">MDLKKVAVENLQKYLRIPTVHPNVNYGPAVKFLESLAGELGLPVKVLEYHPSNPIVLISWVGEQPNLPSILLNSHMDTVPVNEKKWAHNPFGAEIDEYGNIHGRGAQDCKGIGMIYIETIRRLKQAGVQLKRTVHVLFVPDEELGGTKGMGAFTGTKEFKELNVGFAIDEGFGDVGNKFLASYADRLGRKMVIHCEGTAGHGSLLLHNTAGEKLAKVLTKFYNERRQQKEKLSIGKLGLGEVTSINLTKMEGGLSSNIIPQKLSATIDCRVTPKDNVGEFEDMINRWCREAGDGVTVEYLHKSESAPATALNDSNPYWVAFEETVTQLQTWIYPASTDAIHLRAVGVSTIGFVPFRYTPFLKHADNESLNVNTFLEAIDVYTKILPQLANERKKRWAAQGKRRGIRSASASNTDSRLPEGMTPNKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A297</accession>
    <name>A0A5N4A297_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GPN-loop GTPase</fullName>
            <ecNumber evidence="9">3.6.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PPYR_03221</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Binds to RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="9"/>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A297"/>
    <dbReference type="FunCoup" id="A0A5N4A297">
        <property type="interactions" value="1648"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A297"/>
    <dbReference type="OrthoDB" id="243313at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17870">
        <property type="entry name" value="GPN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000888">
        <property type="entry name" value="GPN-loop GTPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030230">
        <property type="entry name" value="Gpn1/Npa3/XAB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF8">
        <property type="entry name" value="GPN-LOOP GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="XPA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="295"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00055682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0791421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="350" mass="39141" checksum="21A2A2E561179267" modified="2020-02-26" version="1">MGTEATKTPTCLLVLGMAGSGKTSLVSCLSRSERKPYTVNLDPACIQLPYFAHIDVRDTVNYKEIMKQYQLGPNGAIVTSLNLFSTKFADVTDFISKCTTEHCVLDTPGQIEVFTWSVSGTIITEALASMFPTVILYVIDTVRSTKPVTFMSNMLYACSILYKTRLPFIIVMNKTDIVEHSYAVNWMKDFELFHEALEADESYISNLTRSMALALDEFYQNLRVCGVSAATGQGLDELFSLIDDAKVEYERDYKAEWEKIRQKAASGDASRENPSSSLVTTVPSGRELADVYLRRPGNESSSDSEGEEVNVHEFGTNATADEENFAKVLQQQREMQIRRAKEAEVRKQAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A2U4</accession>
    <name>A0A5N4A2U4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PPYR_03437</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A2U4"/>
    <dbReference type="FunCoup" id="A0A5N4A2U4">
        <property type="interactions" value="240"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A2U4"/>
    <dbReference type="OrthoDB" id="10012075at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000328">
        <property type="entry name" value="CLUMA_CG000981, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051170">
        <property type="entry name" value="Neural/epithelial_adhesion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231">
        <property type="entry name" value="CTX-RELATED TYPE I TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231:SF271">
        <property type="entry name" value="DPR-INTERACTING PROTEIN GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024344091" description="Ig-like domain-containing protein" evidence="9">
        <location>
            <begin position="25"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="39"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="141"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="241"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0791637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="390" mass="43455" checksum="4A672C6635094C25" modified="2020-02-26" version="1">MWLTKKSKSAILGVLALLVNSLLAYQDDWPAARLTSDGPAFLTPIHNLTVNVGREAVLSCSVGNLGRYKVAWVRAEDQTVLSLNSKVVTHNSRISVSHDSQHTWQLRIRQLKESDRGCYMCQINTSVLKTQEGCIDVNVPPDIVNDDTSGDLSVLEGENTTLWCKAVGHPSPRIAWRREDGHPITIRKGHKEIVEVDIYNGSNLHFWRLDRKQMGAYLCIASNDVPPAVSKRIALSVNFAPVIKVPNQLLGAPLNTDVQLECYVEAFPNTINYWLKNRGEMLLNGTRYAIREQRKGYRVYMSLIVRSFSTKDVGTYNCVSTNSLGRAEGTLRLYEIKVSHAGTHEYVNGVGGIAESARSHISRDTNGKSPLCIQQVQFLITIACIVINPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A4D2</accession>
    <name>A0A5N4A4D2_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PPYR_14126</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A4D2"/>
    <dbReference type="FunCoup" id="A0A5N4A4D2">
        <property type="interactions" value="51"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A4D2"/>
    <dbReference type="OrthoDB" id="10059102at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000077">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050430">
        <property type="entry name" value="Peptidase_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276:SF91">
        <property type="entry name" value="AT26814P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276">
        <property type="entry name" value="POLYSERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Peptidase S1" evidence="9">
        <location>
            <begin position="52"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0792167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="279" mass="30190" checksum="3678E218287ED68B" modified="2020-02-26" version="1">MRVLENSIKAKHVISCSPCDMIKILLIAALAALAIEASPRLRAGVPQLDGRIVGGDDADIEDYPHQVSLQVLDIHNCGGSIIAPNLILTAAHCTADYETSYLSVRCGSSIMEEGGQVLTVAQKYDHPSYDPTRTDYDLSVLMLFGKITLSSKAKIIDLVPAHVQEGGRSAFVTGWGALYSDGPSPQQLQVAKVFEENRDACNKAFRGKITDRMICFKAPGRDSCQGDSGGPLVSDGHQVGIVSWGYGCADARYPGVYSHLNNVVLRKYVLEHIKMHATM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A4Y4</accession>
    <name>A0A5N4A4Y4_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_14344</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A5N4A4Y4">
        <property type="interactions" value="1647"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A4Y4"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052575">
        <property type="entry name" value="SSU_processome_comp_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057525">
        <property type="entry name" value="UTP20_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046523">
        <property type="entry name" value="UTP20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011430">
        <property type="entry name" value="UTP20_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17695">
        <property type="entry name" value="SMALL SUBUNIT PROCESSOME COMPONENT 20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17695:SF11">
        <property type="entry name" value="SMALL SUBUNIT PROCESSOME COMPONENT 20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20416">
        <property type="entry name" value="UTP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23099">
        <property type="entry name" value="UTP20_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07539">
        <property type="entry name" value="UTP20_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 20 N-terminal" evidence="1">
        <location>
            <begin position="835"/>
            <end position="1433"/>
        </location>
    </feature>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 20" evidence="2">
        <location>
            <begin position="1692"/>
            <end position="1908"/>
        </location>
    </feature>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 20 C-terminal" evidence="3">
        <location>
            <begin position="2263"/>
            <end position="2596"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0792385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="2661" mass="302279" checksum="8AD139437E1C5610" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A587</accession>
    <name>A0A5N4A587_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">2-(3-amino-3-carboxypropyl)histidine synthase subunit 1</fullName>
            <ecNumber evidence="4">2.5.1.108</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Diphthamide biosynthesis protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Diphtheria toxin resistance protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PPYR_14463</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">1611_PpyrPB1</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine = 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36783"/>
            <dbReference type="Rhea" id="RHEA-COMP:9748"/>
            <dbReference type="Rhea" id="RHEA-COMP:9749"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73995"/>
            <dbReference type="EC" id="2.5.1.108"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DPH1/DPH2 family. DPH1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.108" evidence="4"/>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A587"/>
    <dbReference type="FunCoup" id="A0A5N4A587">
        <property type="interactions" value="27"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A587"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090560">
        <property type="term" value="F:2-(3-amino-3-carboxypropyl)histidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd22127">
        <property type="entry name" value="F-box_FBXL16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11840:FF:000001">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11850:FF:000001">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11860:FF:000002">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:002228">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11840">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11850">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11860">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016435">
        <property type="entry name" value="DPH1/DPH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042263">
        <property type="entry name" value="DPH1/DPH2_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042264">
        <property type="entry name" value="DPH1/DPH2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042265">
        <property type="entry name" value="DPH1/DPH2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057207">
        <property type="entry name" value="FBXL15_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00322">
        <property type="entry name" value="diphth2_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762:SF1">
        <property type="entry name" value="2-(3-AMINO-3-CARBOXYPROPYL)HISTIDINE SYNTHASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01866">
        <property type="entry name" value="Diphthamide_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25372">
        <property type="entry name" value="DUF7885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00032">
        <property type="entry name" value="Radical_SAM_3-amino-3-carboxyp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="F-box" evidence="16">
        <location>
            <begin position="572"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="domain" description="F-box/LRR-repeat protein 15-like leucin rich repeat" evidence="17">
        <location>
            <begin position="715"/>
            <end position="836"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF25372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAB0792504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="948" mass="105904" checksum="975478748FC71D91" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A664</accession>
    <name>A0A5N4A664_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_14761</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A664"/>
    <dbReference type="FunCoup" id="A0A5N4A664">
        <property type="interactions" value="40"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A664"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000002">
        <property type="entry name" value="Transmembrane protease serine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252">
        <property type="entry name" value="ACROSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252:SF7">
        <property type="entry name" value="HYALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024463934" description="Peptidase S1 domain-containing protein" evidence="3">
        <location>
            <begin position="19"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="4">
        <location>
            <begin position="52"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0792802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="292" mass="32069" checksum="E712586A6A5D31D7" modified="2020-02-26" version="1">MEIALLLVISTFVAGFWAMNNCKCGSPHFFTNQPLVADVPCGRRKLGRAAKVVGGENATEGEFPWLVSLTRRDPSRARFVFAILAHSHHHTGSSPIPTNQIRVTVAQHDLVLPSPYKYERSVHSAILHPEYICNKVKNDLAILELEKELEWSDRVLPACLPETTGGKQLDDVLATVAGWGWTNENNQLGGRADTLQKATVNILKMETCRAWYKSQGKKTKIHDTQICAGYEQGGIDSCWADSGGPLMVTTNSGEQMVVGVVSTGIGCARPLLPGLYTRVSDFIPWIESVVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A7F7</accession>
    <name>A0A5N4A7F7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4485 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_12887</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A7F7"/>
    <dbReference type="OrthoDB" id="78101at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027831">
        <property type="entry name" value="DUF4485"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14846">
        <property type="entry name" value="DUF4485"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4485" evidence="2">
        <location>
            <begin position="8"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        <source>
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        </source>
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        <source>
            <dbReference type="Pfam" id="PF14846"/>
        </source>
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            <dbReference type="EMBL" id="KAB0793267.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="2585" mass="290972" checksum="0F7895BB6BA9A477" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A7H9</accession>
    <name>A0A5N4A7H9_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_12906</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
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            <taxon>Pterygota</taxon>
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            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
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            <taxon>Elateroidea</taxon>
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            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <begin position="1"/>
            <end position="19"/>
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        <location>
            <begin position="40"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
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    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAB0793286.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
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    </evidence>
    <sequence length="354" mass="39033" checksum="E631B80B59816333" modified="2020-02-26" version="1">MVRKLLIICFIVLVSSVFGQDLSSEDAAIEDFNDDDIEGFYLERGDGGAGQRRKRDANSGSKESSEEKKKDKVIFIDQKRKSGESSEEQKSKDDKQIVHDSSEQGPGNYKDGIKKSDGKSHDSSEEGSGDSKGGIKKPGDKSHDSSKEQKENLKDDKKKPGDKGDSNEKDDKKNPDKKRDSSEKDNSSEKAKGDKGGSKEKDDQKKPGDKRDSRENNSSEEGKGKDNKKTPGDKGNSKEKDDKKKPGNKRDSSEKYNSSEEAKGEKGGSKEKDDKKKPGDKRDSKENNSSEEGKGKDDKKTPADKDNSKEKDDKKKPGDKRDSSEKDNSSEETKGKDNFLSLLLELFNGGVASF</sequence>
</entry>
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    <name>A0A5N4A8L1_PHOPY</name>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
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            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
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            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="InParanoid" id="A0A5N4A8L1"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zinc knuckle domaincontaining protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF7">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="3">
        <location>
            <begin position="372"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="663"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="663"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="676"/>
            <end position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0793598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="750" mass="87162" checksum="3E6D765F2FA86971" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A927</accession>
    <name>A0A5N4A927_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PPYR_13456</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Trehalose transporter subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A927"/>
    <dbReference type="InParanoid" id="A0A5N4A927"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000218">
        <property type="entry name" value="facilitated trehalose transporter Tret1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000055">
        <property type="entry name" value="Facilitated trehalose transporter Tret1-2 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050549">
        <property type="entry name" value="MFS_Trehalose_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021:SF46">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="317"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="351"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="388"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="421"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="501"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="529"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="555"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="615"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="760"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="794"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="831"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="864"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="12"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="459"/>
            <end position="886"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAB0793836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="909" mass="98090" checksum="95EB867D1103DAC1" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AAE7</accession>
    <name>A0A5N4AAE7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Protein glass</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PPYR_11145</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">1611_PpyrPB1</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Transcription factor required for gene expression specific to photoreceptor cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0794306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AAE7"/>
    <dbReference type="FunCoup" id="A0A5N4AAE7">
        <property type="interactions" value="52"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AAE7"/>
    <dbReference type="OrthoDB" id="8113227at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007601">
        <property type="term" value="P:visual perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000310">
        <property type="entry name" value="GLIS family zinc finger 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001159">
        <property type="entry name" value="Protein glass"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000875">
        <property type="entry name" value="zinc finger protein 236 isoform X7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000060">
        <property type="entry name" value="zinc finger protein 436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF29">
        <property type="entry name" value="MYONEURIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00614">
        <property type="entry name" value="ZnF_BED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="11" id="KW-0844">Vision</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="259"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="287"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="315"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="343"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="371"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00058744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00067600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAB0794306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="401" mass="44374" checksum="E7C0F84D9F54F5E7" modified="2020-02-26" version="1">MDASYIPNNPQFGLQLECNWTTGVQPCQNSCQSSCPDELSSCWPEDMGSFTLPLDLEPLPTLFPFSPCSSANGLFKTEEALQNSSPITKDTKAPSADMADVLLSLKHAVVHPGQTEKYDPQQQMYHPQVLLSPGGYGGSFCDQAFPQQPPMFPSMSVNVSMNMTMHGYHPNSNYPSAEITCPQVQWNSAPQVSVPGGYNSQGLLSPSYAGATYSFTADFRPPQDGPVISASYKPVSVSFGSPRRKHFQNPMEDDCQKPNVCRICGKSYARPSTLKTHLRTHSGEKPYRCVDCNKSFSQAANLTAHIRTHSGEKPFRCPVCDRRFSQSSSVTTHMRTHSGERPYRCRLCKKAFSDSSTLTKHLRIHSGEKPYECKLCLLRFSQSGNLNRHMRVHGNGGILTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AB46</accession>
    <name>A0A5N4AB46_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_11370</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0794531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AB46"/>
    <dbReference type="InParanoid" id="A0A5N4AB46"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47481">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47481:SF7">
        <property type="entry name" value="CCHC-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="244"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="214"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="214"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0794531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="385" mass="43655" checksum="B427FC9BAFA940F9" modified="2020-02-26" version="1">MESDRVNIEKLEGGSNWMTWKFQMLQVLEASELFDVVDGTDSPPSNRDENYRTAIVAWKKNDAKARRAISTACKKQPLLQIMNCDTANSMWTTLKSTYEQTLKSNVLFLQQKYYSFTKEPGDDIATCISKLMEIVQQLKDQKENISDTMVMTKILMALPAEYNHCHSAWESTSAENQTMSNLRARLMAEELRLKSQGQIEHVEALMAKQNFSKKCNSNSKKGHSSGQNKKQRGTNNSGKLKGSCFSCGELGHWKRDCPQKKQNSSDNSKKHDSALADAFVCHGTTLTEDKDSWVLDSGASDHMCHRREWFYNFVETSSHIIIGNGEKIMAQGRGDINLLAFDGNQWIPRRMVDVLYVPEIHVNLFSSGKAMDRGYQLQSDNFANC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ABC4</accession>
    <name>A0A5N4ABC4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PPYR_08882</name>
        <name evidence="7" type="ORF">PPYR_11453</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0794614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ABC4"/>
    <dbReference type="InParanoid" id="A0A5N4ABC4"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050688">
        <property type="entry name" value="Zinc_finger/UBP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24403:SF67">
        <property type="entry name" value="FI01116P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24403">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13909">
        <property type="entry name" value="zf-H2C2_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="284"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0794614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0797889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="310" mass="36390" checksum="9E1A217F64FFAD0C" modified="2020-02-26" version="1">MSSPETVDDEEEEAEDPIDLEYETELSLFISEQELLINHNVNRESIKQEGVSRKDSQEIVRTPFENKICNSQRKQYSVYYIPVRSTVAEFNCSYCDYITKWKNNLTAHMSGRHRATTFKYPHCEYVRKWMRSLPVFKCNCCTYATKWKYNLTAHVSGRHGSTFLLLHHKGQVDQGPVKPETTPISKKKTESSFDIHNHRSEKVEDSLAKTIFWRHYVDLLLNATPATDFDRSNRWKNKFVPNIVAKCEQCDFVSKSKQSLALHVCRFQPYLVDRMKICYNSDGFKCIHCDYSTKFNKRLSLHMQSCHLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AC76</accession>
    <name>A0A5N4AC76_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PPYR_11755</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0794916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AC76"/>
    <dbReference type="InParanoid" id="A0A5N4AC76"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000023">
        <property type="entry name" value="Pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.370:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF12">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="7">
        <location>
            <begin position="214"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="234"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0794916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="894" mass="100470" checksum="BA24973C2AD11F9A" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ACG3</accession>
    <name>A0A5N4ACG3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PPYR_11840</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0795001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ACG3"/>
    <dbReference type="InParanoid" id="A0A5N4ACG3"/>
    <dbReference type="OrthoDB" id="40579at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001397">
        <property type="entry name" value="Datilografo, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000508">
        <property type="entry name" value="Myeloid zinc finger 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001480">
        <property type="entry name" value="Si:cabz01071911.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000765">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000671">
        <property type="entry name" value="Zinc finger protein 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393:SF156">
        <property type="entry name" value="ZINC FINGER PROTEIN 271-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="107"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="166"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="194"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="222"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="250"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="278"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="306"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="337"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAB0795001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="407" mass="46646" checksum="D0835A5DA93BF173" modified="2020-02-26" version="1">MFLLKVKLKKRTSISSDSEDLLSGTSDAEWHEDGSVTLRRCLEGWDQYPWTCSDCQEALPNADALKDHHSLVHDQPPKYVCAECPKMYTKYSTFVGHVRTHRDHLRFCCDVCGKWYGTSRAQEQHRASHYEQKPHTCTTCGKRFRVQSSLLVHARSHLPAEVKNKHQCDQCPKRFGTRPNLMAHKRIHSGIRDFTCDQCGKSFVQKGNLDNHMLTHTVARPFTCHACGKAFKTAVRLRKHSSVHSGLKPHQCDVCGRQFRERGTLKEHHRIHTGAMPFTCEYCGKSFRFKGVLTTHRRQHTGERPYSCLECQHHFTNWPNYNKHMKRRHGINTSVTVRKPQSIPPTGMPQRNPPGTVLAPPQPTTVTMLSSVPHATATITDNFAEPPPFYPVLNLYNLPEELLQQRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ACL2</accession>
    <name>A0A5N4ACL2_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cyclic nucleotide-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_11895</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0795056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ACL2"/>
    <dbReference type="InParanoid" id="A0A5N4ACL2"/>
    <dbReference type="OrthoDB" id="2021138at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098855">
        <property type="term" value="C:HCN channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003254">
        <property type="term" value="P:regulation of membrane depolarization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035725">
        <property type="term" value="P:sodium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.630">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051413">
        <property type="entry name" value="K/Na_HCN_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45689:SF14">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45689">
        <property type="entry name" value="I[[H]] CHANNEL, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00888">
        <property type="entry name" value="CNMP_BINDING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="391"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0795056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="518" mass="60839" checksum="89EEFD470C934EBC" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AEC9</accession>
    <name>A0A5N4AEC9_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_09737</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0795676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AEC9"/>
    <dbReference type="InParanoid" id="A0A5N4AEC9"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="405"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0795676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="461" mass="50709" checksum="DEE2DE56259E347D" modified="2020-02-26" version="1">MTALLDEVDQELEARRKAHEVASQKEDGELANGCAKQPPDHEQPSVKILGMEMTASCEGGQKWDRCESPVIPKSQAPPEPTEPPQEIFLGGILPAQSQLLVADSTVEEETNSLSSSADPPVILASKMTLSVISLDAPENEEAHVVEDVVDESKYTTAAAGDISDEEASDIVDEIEKSTNQDDGAKKGDEITEAPLLTQLNDIISSDINNAVESVLNDGLIKNVESVDIVNTIQDDESPIVTALKDQLSKTTEDIYDSLIESVGNDTKQDEDGTIDINEQIDMSQLEDEVRKVVDDDIQYVSKVEKDQSDVENKVDEDDVQKMDLNDEGSEEENSDIEEVEDGTDANSFDDEIEEIIIFEDEIDMNDDEDRVFISHESVQNIGDIIDEIITDGARRLEIVNDIDNNDNLEHSVDPFNDQGDDNSDVNMSRNNNLASDVSNSLGQHDEVRNDTKGEQEKDCAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AEG1</accession>
    <name>A0A5N4AEG1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Probable nuclear hormone receptor HR3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Nuclear receptor subfamily 1 group F member 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PPYR_09776</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">1611_PpyrPB1</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Putative receptor whose ligand is not yet known.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nuclear hormone receptor family. NR1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0795715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AEG1"/>
    <dbReference type="FunCoup" id="A0A5N4AEG1">
        <property type="interactions" value="59"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AEG1"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004879">
        <property type="term" value="F:nuclear receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07165">
        <property type="entry name" value="NR_DBD_DmE78_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06941">
        <property type="entry name" value="NR_LBD_DmE78_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.565.10:FF:000044">
        <property type="entry name" value="Ecdysone-induced protein 78C, isoform D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000003">
        <property type="entry name" value="Nuclear orphan receptor ROR-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048008">
        <property type="entry name" value="NR_LBD_DmE78-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001728">
        <property type="entry name" value="ThyrH_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45805:SF10">
        <property type="entry name" value="ECDYSONE-INDUCED PROTEIN 78C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45805">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR HR3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00546">
        <property type="entry name" value="THYROIDHORMR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9 14" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 14" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 14" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5 14" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="16">
        <location>
            <begin position="65"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="17">
        <location>
            <begin position="196"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="141"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00055215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00072676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00077334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAB0795715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="432" mass="48420" checksum="ED3918EC0A58FCA3" modified="2020-02-26" version="1">MEPSSSTPSPPGLADSTFTSVKQEPNSNPPSPTDDSSTNSSASLRSKEQHYVAADSNSTSTTKSFVPCKVCGDKASGYHYGVTSCEGCKGFFRRSIQKQIEYRCLRDGKCLVIRLNRNRCQYCRFKKCLAVGMSRDSVRYGRVPKRSRERSTDEISRVTTTDADQSDNETKQLAVYDIILTVSQAHHANCGFTEEHTRHLVRKSLSVPPTTSPDDGEVATSTADSLEQQKCWLWQQFAANVTPCVQRVVEFAKRVPGFCDLGQDDQLILIKVGFFEIWLSHVARLTSNTSMVFDNGITVTRQQLEIMYDVDFVASIIHFANTFNALALNDTELGLFSAVVLLTADRPGITDVKTIEHHQDKLIEAFKVQVGRNHGSEPQIFSNLLIKLPELRNLGTKHTSHLDWFRVNWTKLTLPPLFAEIFDIPKCEDDLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AF57</accession>
    <name>A0A5N4AF57_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Lipase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_10002</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0795941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AF57"/>
    <dbReference type="FunCoup" id="A0A5N4AF57">
        <property type="interactions" value="116"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AF57"/>
    <dbReference type="OrthoDB" id="199913at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00707">
        <property type="entry name" value="Pancreat_lipase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002334">
        <property type="entry name" value="Allerg_PlipaseA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013818">
        <property type="entry name" value="Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033906">
        <property type="entry name" value="Lipase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000734">
        <property type="entry name" value="TAG_lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610:SF190">
        <property type="entry name" value="VITELLOGENIN-3-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00151">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00825">
        <property type="entry name" value="DOLALLERGEN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00821">
        <property type="entry name" value="TAGLIPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024402708" description="Lipase domain-containing protein" evidence="5">
        <location>
            <begin position="24"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="Lipase" evidence="6">
        <location>
            <begin position="66"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0795941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="339" mass="37575" checksum="9B12FCE7C70E2826" modified="2020-02-26" version="1">MAFKLSVFLAIAFFSLLLWGNEGRRFLPFENDPYRIRNVYYYNGARVLVEDLTNAKLQARSDIPLTDLALYLYTRQGSAYKINMTQIKDLQISQFYQPKNENFFIIHGWKNSHLSEVNTLITKALLETSDINVFVLDWSKIASGLYTTAFLSVEGVGSHLANFIVALVREFQLDIRRVALVGHSLGAHIAGCAGAAVNGTLRYIVGLDPAGPLFSLWNTKNRLDKSDAEFVQVIHTAGGLAGMLSSIGHADYFPNDGTPPQPGCGMDLIGVCSHSQAYVYYSESLTRNGFAALNCSSYTMYREGVCAHQHLSYLGRLPIDKSANGDYYLDTNMDAPYGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AFF6</accession>
    <name>A0A5N4AFF6_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_10133</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AFF6"/>
    <dbReference type="InParanoid" id="A0A5N4AFF6"/>
    <dbReference type="OrthoDB" id="10002384at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0796072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="264" mass="29959" checksum="8C9143E9DE529238" modified="2020-02-26" version="1">MANKCRYERRRTLAERLNNWRARNDSTNVSLLLSGDHLSEPKKTEKRSPCQTCYCRKSPVLSKFNLRPISVSEGYSHSSPAELSQRTSSGPRPAAVALRTVEEARSELISPRRRTVRSNSPEPARLQNLETFRKDNYFECHSSANIHDVPVGDHKCVHKFVLNNRLIPEPLNADPFGTSRCVRCNKPMRIKAEEERSKPLTQRARPRITPNAINIAGETNVTEIQIPANFNKLLELFQETATNISKVKPTNTLALRHQKGVVLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2024-05-29" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AFK4</accession>
    <name>A0A5N4AFK4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alcohol dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_10152</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AFK4"/>
    <dbReference type="InParanoid" id="A0A5N4AFK4"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229:SF8">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0796091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="258" mass="27939" checksum="0030AF87F0679BFC" modified="2020-02-26" version="1">MYVVTGKVALITGGARGIGAAIARELLKAGLKGVVIIDINEEEGLHLVDEFNNEFGQGKALFLKTDVSLRQELDDALRRTVEVYYNLDIVINNAVVSGERDWERNIAVNLIGTINGAVLAHEKYLEKYRSGEEAVIINISSVAGLYPCAPFPIYATAKSGIIGLTRTLGCTPHYTRTKIKVIAVCPGATDTLSVSPINFLGPAYFDLYDDLRKCTPPPQRVSSVSKAVLQIIEGGESGSVWVVAQNKEPSVVKFLDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AFZ5</accession>
    <name>A0A5N4AFZ5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GST C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_10280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AFZ5"/>
    <dbReference type="InParanoid" id="A0A5N4AFZ5"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43969">
        <property type="entry name" value="GLUTATHIONE S TRANSFERASE D10, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43969:SF9">
        <property type="entry name" value="GLUTATHIONE S TRANSFERASE D10, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST C-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0796219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="125" mass="14740" checksum="0D2DED0EB20CC391" modified="2020-02-26" version="1">MSSMSTWFVQRLIPNCFQRLRVQRRDLPERNITRLCDMYETLNNFIKNADWVAGNSVTLADLSLIPNITLAHHLLMAIDVQKYPNVIRWIKNAELLPFYYENTNYLTAITDFVHRPRTNKVKSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AG85</accession>
    <name>A0A5N4AG85_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Methanethiol oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_10370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the selenium-binding protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AG85"/>
    <dbReference type="FunCoup" id="A0A5N4AG85">
        <property type="interactions" value="590"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AG85"/>
    <dbReference type="OrthoDB" id="10252446at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008430">
        <property type="term" value="F:selenium binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008826">
        <property type="entry name" value="Se-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23300">
        <property type="entry name" value="METHANETHIOL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23300:SF0">
        <property type="entry name" value="METHANETHIOL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05694">
        <property type="entry name" value="SBP56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75011">
        <property type="entry name" value="3-carboxy-cis,cis-mucoante lactonizing enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0711">Selenium</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0796309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="475" mass="53618" checksum="A5744EFE6133E658" modified="2020-02-26" version="1">MSGPGYATPLDAMTKGPREKILYVVCVQPNSTEGKHDLLATVDVDPKSPTYCKIIHRTYTRYPNDELHHTGWNVCSSCHNVKGCHHSLKRDKLIMPSLTSKRIYVVDTGKNERAPEIHKVIEPSELSALDLSYPHTTHCLPSGEIMISTMGDNQENGKGEFVLIDAKTYKVKGTWTDGKTASFGYDYWYQPFHDVLIASEWTSPKVFKRGFSFDDVATDDIYGKSINVYSWKTRQLKQVIDLGRDGFAPLETRFLHNPRESQGYVGCAVTANVFRFYKKDDGTWDTHKVISVPPKKVSGWVGENMPGLMTDIIISLDDKYLYFSNWLHGDVRQYDITDRKNPKLTGQVFLGGSILSDSKITVVEDQELSSQPDPVFIKGKRLYGSPQMLQLSLDGTRLYVTSSLFSAWDRQFYPDMIEKGGFMAKLDVDVKNGGMSLDKDFLVEFNGEPDGPLLPHEMRYPGGDVTSDIWLVDEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-06-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AGW7</accession>
    <name>A0A5N4AGW7_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_10646</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AGW7"/>
    <dbReference type="InParanoid" id="A0A5N4AGW7"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0796585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="100" mass="11196" checksum="B5245FB1DE402DEE" modified="2020-02-26" version="1">MVQSGVLEKVKYSQWASPILLLSLKRKQGNSLAHFAVAILPSPVRRRQSAIASLPSGHFAVDPVRRRHSAGEPVDPRHFAVASLRRRRKTSMLLNHIKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AIN8</accession>
    <name>A0A5N4AIN8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">A-kinase anchor protein 7-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_08153</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AIN8"/>
    <dbReference type="FunCoup" id="A0A5N4AIN8">
        <property type="interactions" value="1515"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AIN8"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1140.10">
        <property type="entry name" value="Cyclic phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019510">
        <property type="entry name" value="AKAP7-like_phosphoesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009210">
        <property type="entry name" value="ASCC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13360">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13360:SF1">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10469">
        <property type="entry name" value="AKAP7_NLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF027019">
        <property type="entry name" value="Euk_LigT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="LigT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="A-kinase anchor protein 7-like phosphoesterase" evidence="1">
        <location>
            <begin position="106"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0797159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="322" mass="36617" checksum="6366D1752821AF7D" modified="2020-02-26" version="1">MFLFCIDSVVTDLNLQQEHNFILTETDNRFTTSFCLPPVYYVGLNNFPYLSRRKIEVDTRTVIRTPQRDDGSMTISGDCADDVVNARRTVQSIVAEIRNKQPAAQFISIPVNSEEVQRNFQQFKDAILSAGPIEGVEDSVFQSPLKLHLTICVFVLLSPSEKEEAVKALNDCKTEVLDTFLSSETPLKVHVAGIDCMNDNHSKVNVLYANAKIVQDNNEEVLQKLANAISDYFYNRGLLIQYTDNVRLHVTLMNTKYRSKSAQNTPKRSRWPTKRIPFNATSIIEKYKDFYFGEKVLDSIHLSCMSSKGEDGFYAPLSVIRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AJK1</accession>
    <name>A0A5N4AJK1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PPYR_08513</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AJK1"/>
    <dbReference type="FunCoup" id="A0A5N4AJK1">
        <property type="interactions" value="111"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AJK1"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048619">
        <property type="term" value="P:embryonic hindgut morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009880">
        <property type="term" value="P:embryonic pattern specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001499">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001385">
        <property type="entry name" value="zinc finger protein 774"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050717">
        <property type="entry name" value="C2H2-ZF_Transcription_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14196:SF10">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14196">
        <property type="entry name" value="ODD-SKIPPED - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="449"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="477"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="332"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="391"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="344"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="354"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="415"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAB0797520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="505" mass="55416" checksum="D9856F0E8030691D" modified="2020-02-26" version="1">MLTMATMKYPNVSGGSNMAVSGNGPHVDDVDSLFASSCWQNSASNVQNDFMETQKLILDSSINNLGSDKLLLDNSINHDNEIATKATMDALDNLLLNSQPINANLAELKPLPPFTGYTGHLSINGIQGHHYHALSQRIPEENNNSYNSFNEQNSLVSSSTCNAITDSSDETKPLYGVDEVVGKIGYTDCVNPDSVSGTKIYDECGQPTADSVTHIKTEIAEYDISSIDDIATLIGSAIADTTVPNHAHEEDPSGSRDSWMDLDAWIEGACNDQQKSLIITQDGLSEFVIQNSPQNNNEFKTHVEYSSKLHSPPGNSTLQSLLTHGYMPLLQNRLQNGPPIKQEAPSSTNYGLESSTTSSPPSVVSTTDNLVLSINGRFVHHYSVHGIEPDDRIRSPEILGPNYPHTTTTTPNSTKKSRSRAQKKQHTASSTVFQTEQNLGLLGKEKPVHRCSICNRGFLNKSNIKVHLRTHTGEKPFRCETCAKAFRQKAHLLKHQQIHKRIGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AK32</accession>
    <name>A0A5N4AK32_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_08571</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AK32"/>
    <dbReference type="FunCoup" id="A0A5N4AK32">
        <property type="interactions" value="15"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AK32"/>
    <dbReference type="OrthoDB" id="7881430at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23992">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.20">
        <property type="entry name" value="Pheromone/general odorant binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006170">
        <property type="entry name" value="PBP/GOBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036728">
        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01395">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024319861" evidence="1">
        <location>
            <begin position="17"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0797578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="135" mass="15410" checksum="2163906EA10EF4D8" modified="2020-02-26" version="1">MKSFILLCVQIILAQSKLHPQVITDWNNLQKDFIESCSKEANLDPTIPPRILEDLYMPDEANFQCYIRCVMRNNKLILPDNNVNAKELAEVVHITPETAMKCIKSAETETDVCRKPYLVGICCIESKFETQSCNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AKL4</accession>
    <name>A0A5N4AKL4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PPYR_08806</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AKL4"/>
    <dbReference type="InParanoid" id="A0A5N4AKL4"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000218">
        <property type="entry name" value="facilitated trehalose transporter Tret1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050549">
        <property type="entry name" value="MFS_Trehalose_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021:SF39">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="291"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="320"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="367"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="436"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="1"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0797813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="509" mass="57098" checksum="0BD88B9445B1CE0B" modified="2020-02-26" version="1">MIRIALSQTMAIMVKNLIMVSFGMSIGFRTVLIGGVLHDDEFQGAGESELSWLGSISMLTLLVGCIGSGFVTQPIGRKRSMQFVTIPYVSCWVGYYFSTKIWHLYIVLMVMGFFSGLVEGPFNTYVSEVTQPHLRGVLSISGSMSVMLGSFLQFLIGTFFKWRICALISCAFPLVTFFLFFLVPESPYWLISNNKLVEAKKSLAWLRGWTKVENIELEIGSIIRHYAEERDQQTRKQSSFKEYFTPFLKKSFIYPLLLVSFAFMISSFTGASTLQTYAIAIFGTMKLPINSYYATVCLGSVQLLGSLISIFLIRFLGKRRLFFIAISCMCICNMIIAIYAHFSGALQINLTKDSGVSTNLDVSDYKWVPLTFLILLSFMNNGGVHALPWILMSEVYSYKTRSVGCGLSSAVSSLLSFVANNLFLRVTSFISIPGMYTLHCAVCIVGFLVLYFYLPETEGKSLETIADHFAQKIKLDNKVQKKPLKKGIDNTLFEYNESNANVSHTVSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AMZ6</accession>
    <name>A0A5N4AMZ6_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_09669</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AMZ6"/>
    <dbReference type="InParanoid" id="A0A5N4AMZ6"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0798676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="95" mass="10887" checksum="A8E4DF4242BE6432" modified="2020-02-26" version="1">MCESGHFGSNIRDFSIVEPRQTRTSTRRLLLNRPRGHLSPGDYLEIDTDNSHMAEILRRIPELLKVTGNAISPERKPRAATMSEKDLTKHVYRNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ANL6</accession>
    <name>A0A5N4ANL6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GDP/GTP exchange factor Sec2 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PPYR_06800</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the SEC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0798920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ANL6"/>
    <dbReference type="InParanoid" id="A0A5N4ANL6"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070319">
        <property type="term" value="C:Golgi to plasma membrane transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21044">
        <property type="entry name" value="Rab11BD_RAB3IP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040351">
        <property type="entry name" value="RAB3IL/RAB3IP/Sec2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009449">
        <property type="entry name" value="Sec2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14430">
        <property type="entry name" value="RABIN3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14430:SF0">
        <property type="entry name" value="SEC2P DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25555">
        <property type="entry name" value="RAB3A-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06428">
        <property type="entry name" value="Sec2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144284">
        <property type="entry name" value="Sec2 N-terminal region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GDP/GTP exchange factor Sec2 N-terminal" evidence="5">
        <location>
            <begin position="136"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="31"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="141"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="43"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF06428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0798920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="461" mass="52312" checksum="8E94627610E123C8" modified="2020-02-26" version="1">MDSDGSVSIGKGLLMTPKTVGYQYVVSKHKRAGSTGTTGDESYTTDEEDNVDDEPDCSIKEHVTSKLFDNHEHDFAYSDIATIADKVEHLSVMHRNSSDSSVYSDLGLDKTDELHLQYPNLCATNCYKRKDDQVTWTRSAAEVKEQTFAKLQKELQEAHQELKLRDEEVNRLSRIRQDVETELEDLTASLFQEAHHMVQEAKEKQAAAEKALKESQMKVDVLTAEVSALKTLVLTSTPSRPNPHLHPQIDLKGKEELGVALFAKKHRRSPSHYNLKYGRENSPPDSPVRDLSPPVCLGTDIFPKEGLEVDPIVHQEFISWRNNPTLDKTNPFIKRIYTEDINLCLAFDNSKLVTKVAEAVDSGTILIEAVSDKTKAMFPKKCALLEVPRLCFYRMNIGEPDVWYSISQICRNRIISVCDFLNYLKYIERGLVKSSVHEVYWEIIRLRKNMVLARLGLSLNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ANW9</accession>
    <name>A0A5N4ANW9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Splicing factor YJU2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PPYR_06886</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Part of the spliceosome which catalyzes two sequential transesterification reactions, first the excision of the non-coding intron from pre-mRNA and then the ligation of the coding exons to form the mature mRNA. Plays a role in stabilizing the structure of the spliceosome catalytic core and docking of the branch helix into the active site, producing 5'-exon and lariat intron-3'-intermediates.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the spliceosome. Present in the activated B complex, the catalytically activated B* complex which catalyzes the branching, the catalytic step 1 C complex catalyzing the exon ligation, and the postcatalytic P complex containing the ligated exons (mRNA) and the excised lariat intron.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CWC16 family. YJU2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ANW9"/>
    <dbReference type="FunCoup" id="A0A5N4ANW9">
        <property type="interactions" value="796"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4ANW9"/>
    <dbReference type="OrthoDB" id="674963at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000349">
        <property type="term" value="P:generation of catalytic spliceosome for first transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03226">
        <property type="entry name" value="YJU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007590">
        <property type="entry name" value="Saf4/Yju2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043701">
        <property type="entry name" value="Yju2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111">
        <property type="entry name" value="SPLICING FACTOR YJU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111:SF1">
        <property type="entry name" value="SPLICING FACTOR YJU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04502">
        <property type="entry name" value="Saf4_Yju2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="115"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="231"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="283"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="121"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="244"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="258"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="283"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="298"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0799006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="316" mass="36817" checksum="EC646AFF13B849AA" modified="2020-02-26" version="1">MSERKVLNKYYPPDFDPSKIPRMKLPKNRQYTVRLMAPFNMRCKTCGEYIYKGKKFNARKEDVENEDYLGIRIYRFYIKCTRCLQEISFKTDPKNTDYEIEAGATRNFMALKLAEEQAQREEEEEKEEEQNNPMKLLENRTKQSKNEIELLESLEELKDLNRRQRSVDYDSMLLAYDTKLTAREREERMQQLDEEYIKTVKFHSSQKRKVIVEEEIVEDKVEEKKIKVEPDCAGETSVTVTEAKSSELKEPVKKSVPVGNTWNKSIGSLSKNKKLTGLVKINKPSSNTEELKTNNIPSSSLSLLGNYSGSDNSDND</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-06-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4APE0</accession>
    <name>A0A5N4APE0_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_07051</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4APE0"/>
    <dbReference type="InParanoid" id="A0A5N4APE0"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0799171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="113" mass="13101" checksum="91D179894F78A595" modified="2020-02-26" version="1">MCQEKLNCVISISDIDICHRLPSDGKTQKPIIVKFVRRDIKNQIFYNKKKLKGTSIVIREDLTRHLMLLLKEAVNIFGSKRVWTSDGKICVKTDTGIKRCTTRQELNNLVRNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4APZ4</accession>
    <name>A0A5N4APZ4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tetratricopeptide repeat protein 17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_07274</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4APZ4"/>
    <dbReference type="FunCoup" id="A0A5N4APZ4">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4APZ4"/>
    <dbReference type="OrthoDB" id="2115703at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052630">
        <property type="entry name" value="TTC17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16091:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16091">
        <property type="entry name" value="TTC17 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="289"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="1097"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="464"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0799394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1161" mass="130853" checksum="9289E08DB494BB8D" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AQ03</accession>
    <name>A0A5N4AQ03_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_07284</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AQ03"/>
    <dbReference type="InParanoid" id="A0A5N4AQ03"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030258">
        <property type="term" value="P:lipid modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049941">
        <property type="entry name" value="LPLAT_7/PORCN-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13906:SF4">
        <property type="entry name" value="LYSOPHOSPHOLIPID ACYLTRANSFERASE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13906">
        <property type="entry name" value="PORCUPINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0799404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="107" mass="12237" checksum="C757C102EFD8B819" modified="2020-02-26" version="1">MRRSLRHYFLYSTESKFIYDVITFLVTRLAMAYITFTFVVLEFWPSIRLYLHMYLCLHILALLALTLVPRLTSKTVPGISNSIANGSVAHALKHASPLTNSVSNHHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AQ38</accession>
    <name>A0A5N4AQ38_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_07324</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AQ38"/>
    <dbReference type="FunCoup" id="A0A5N4AQ38">
        <property type="interactions" value="63"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AQ38"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22702">
        <property type="entry name" value="PROTEASE-ASSOCIATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22702:SF1">
        <property type="entry name" value="PROTEASE-ASSOCIATED DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="PA" evidence="3">
        <location>
            <begin position="67"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0799444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="183" mass="20569" checksum="88ED33815CC36706" modified="2020-02-26" version="1">MVLANNLHMLDGATTAEIIGGDIFFEIIDPVELEYTYRIRPAKDFGAPFNASFNAQNVFLVPVQPMFCCDTPDNVHIIKGNVALIERGECSFKVKTIVAEKAGAKAVIITDIRKTVEDYYIEMIDDDSVEEAHIPAGFLMGKNGLIIRKTLEKLQQNYATINLPINLTYTPVHEINQPPWLEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AQ46</accession>
    <name>A0A5N4AQ46_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_07263</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AQ46"/>
    <dbReference type="InParanoid" id="A0A5N4AQ46"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33332">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="196"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0799383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="571" mass="65223" checksum="FCEDBEEC7E0AF148" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AQF2</accession>
    <name>A0A5N4AQF2_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PPYR_07318</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AQF2"/>
    <dbReference type="InParanoid" id="A0A5N4AQF2"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000349">
        <property type="entry name" value="metal regulatory transcription factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000071">
        <property type="entry name" value="Putative zinc finger protein 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000125">
        <property type="entry name" value="Putative zinc finger protein 143"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001102">
        <property type="entry name" value="Transcription factor IIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000072">
        <property type="entry name" value="zinc finger protein 143 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF120">
        <property type="entry name" value="KRUPPEL-LIKE FACTOR 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="186"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="216"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="246"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="274"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="304"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="334"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="364"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAB0799438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="436" mass="49087" checksum="2B4A277BAA558C9B" modified="2020-02-26" version="1">MELPTTANDTVYQLYTIINDPSSIIVQNQEPVQTILAVGDESNQVIYYTLPHEEDDEEDGEDEEEVSTVDTIFTSDNSNSLSNVKLVTMQDGQIYLSTDDSVSQLQTDDNKYTLTDEDLPTVQPTVLSTSSEETIVSEKQKDDVEVGNFRQIQLEDGTCALINASLLDSLLDANTMTQVEVKKKKFPCPYVGCEKEFSTAHHLTVHIRCHTGTRPYACNVEGCDKAFATGYSLKAHLRTHTGEKPYPCSLCLKNFKTSGDLLKHIRTHTGEKPFKCPIEGCDKSFTTSNIRKVHIRSHTGERPYTCPVADCGKAFASATNYKNHMRIHSGEKPYVCPVEDCGKRFTEYSSLYKHNAVHQPYRNFKCDYCSQYFKFENTLKLHKKTVHGVIITDNGTELLVKEENEFGSVVLQFSEMNDVPVLLTPESNFFDGEDNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AS00</accession>
    <name>A0A5N4AS00_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_07987</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0800107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AS00"/>
    <dbReference type="InParanoid" id="A0A5N4AS00"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF85">
        <property type="entry name" value="GH03217P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="8">
        <location>
            <begin position="178"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0800107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="315" mass="36413" checksum="FD2D729CD9877C72" modified="2020-02-26" version="1">MDGNSSMFGDIEGKTQKLMDFDTSSSSSSDFSFVEQDNCKKRKICLRVKNYVENIVREYTEVEFKADFRMSRSTAYKIINMFEETSVIPQHTTGREKITAEKAFLLSVWYLSNQESFRQVSSRFDVTYSSAHRCLIRTVNFLLSIKSDVIRWPSLEEMETISANFEKIGGIKKVIGCIDGTHIEINKPRLNQDSYINRKGYHSLLMQGVVNNKKKFIDVFCGEPGSMHDARLLRKSGIYRTILNNANVMKNYIILGDSAYPNLDWLVTPFKDNGKLSVRQKEFNKKISATRVIVENSFGLLKCRFRRLKKWKTSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AS13</accession>
    <name>A0A5N4AS13_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Glycoside hydrolase family 31 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PPYR_06722</name>
        <name evidence="9" type="ORF">PPYR_08000</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0798842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0800120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AS13"/>
    <dbReference type="FunCoup" id="A0A5N4AS13">
        <property type="interactions" value="6"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AS13"/>
    <dbReference type="OrthoDB" id="10070917at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06592">
        <property type="entry name" value="GH31_NET37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050985">
        <property type="entry name" value="Alpha-glycosidase_related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43053">
        <property type="entry name" value="GLYCOSIDASE FAMILY 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43053:SF4">
        <property type="entry name" value="MYOGENESIS-REGULATING GLYCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036147794" description="Glycoside hydrolase family 31 N-terminal domain-containing protein" evidence="5">
        <location>
            <begin position="21"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="6">
        <location>
            <begin position="244"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="7">
        <location>
            <begin position="555"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0798842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0800120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="663" mass="75639" checksum="76A60DF6506530D5" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ASW5</accession>
    <name>A0A5N4ASW5_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_06146</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000004">
        <property type="protein sequence ID" value="KAB0800406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ASW5"/>
    <dbReference type="InParanoid" id="A0A5N4ASW5"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0800406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="285" mass="32654" checksum="31C134F59EE93800" modified="2020-02-26" version="1">MNSNVDFLLRAFENGMFSNDGIVKAYHQVLDLIVSGVRLSTEDVARYNDLRAAAQAIYQRDNNETPSTASASVDNEASARHPQPVTENIGSGIAVRRPLDSEDYKYLEIVSEGSRLIKKYNTMSTNLLFKFKSEHKLEAPIVWLEDVTILRKACVEFWKRFTSENGVDPFRECCTIAGACSLVFRRNFLQENTIGLIPNGGYRMADKQSRIAIQWLLWLEHSEGVRIQHTVNSREVRLREGILVDGFSPETNTVYQFHGCYYHGCEMCYKYQGENRRHIGKDTFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AUJ9</accession>
    <name>A0A5N4AUJ9_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_05375</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000003">
        <property type="protein sequence ID" value="KAB0801021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AUJ9"/>
    <dbReference type="InParanoid" id="A0A5N4AUJ9"/>
    <dbReference type="OrthoDB" id="6620644at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0801021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="143" mass="16222" checksum="FAE01B3991EC8AA7" modified="2020-02-26" version="1">MASYFVDLLLVRILTEHFSMMKCRTRTVVVFLVLKFWTAELAPAITSRQFIPPLPGYIPVYIRSGNTPLEDINMELAEAFQSYALKQARINAMGTLSGIVDADDAITENHEIIPLNNINVEDEENSQSNIIPYSQHIQKIPRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AVM9</accession>
    <name>A0A5N4AVM9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Integrase zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_05731</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000003">
        <property type="protein sequence ID" value="KAB0801377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AVM9"/>
    <dbReference type="InParanoid" id="A0A5N4AVM9"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040676">
        <property type="entry name" value="DUF5641"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF5">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18701">
        <property type="entry name" value="DUF5641"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase zinc-binding" evidence="1">
        <location>
            <begin position="196"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5641" evidence="2">
        <location>
            <begin position="290"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0801377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="343" mass="39403" checksum="02FA39ACA1E1C0AC" modified="2020-02-26" version="1" fragment="single">TIQITTSGDQWYHISSIENPADLLSRGVYPNILENNNLWWEGPKFLKLNSCDWKFNYKLIDTEIPELRTTALTVQTENCLNIIITKFSKVTRIVRIVAYVVRFIKNSKLPKHSRNYGVLVPDELDNALYSLINVVQKVCFPLEYSCLTKGISLKSSSKILSLNPYLHNNLIRVGGRISNSKQCFDQIHPIILPKNHILTELIIKHEHERLVHAGAQMVLSSLREKYWPILGRQLCKKIIRNCVKCFKAYPKSSNYLMGNWPEMATTSGYHPTLLDKVTERIFVRTTNKEEDHVSPLNWPLGRVVKLYPGQDGVTRVVEIKVRGGVVKRAINRVCVLPIEHYVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AVZ6</accession>
    <name>A0A5N4AVZ6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">Trehalase</fullName>
            <ecNumber evidence="3 7">3.2.1.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Alpha-trehalose glucohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_05896</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>alpha,alpha-trehalose + H2O = alpha-D-glucose + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:32675"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:16551"/>
            <dbReference type="ChEBI" id="CHEBI:17925"/>
            <dbReference type="EC" id="3.2.1.28"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 37 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.28" evidence="3 7"/>
    <dbReference type="EMBL" id="VVIM01000003">
        <property type="protein sequence ID" value="KAB0801542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AVZ6"/>
    <dbReference type="FunCoup" id="A0A5N4AVZ6">
        <property type="interactions" value="225"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AVZ6"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004555">
        <property type="term" value="F:alpha,alpha-trehalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005993">
        <property type="term" value="P:trehalose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001661">
        <property type="entry name" value="Glyco_hydro_37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018232">
        <property type="entry name" value="Glyco_hydro_37_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403:SF1">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01204">
        <property type="entry name" value="Trehalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00744">
        <property type="entry name" value="GLHYDRLASE37"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00927">
        <property type="entry name" value="TREHALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00928">
        <property type="entry name" value="TREHALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024397997" description="Trehalase" evidence="8">
        <location>
            <begin position="25"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0801542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="607" mass="70374" checksum="B53E04D9977E0216" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AW69</accession>
    <name>A0A5N4AW69_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ISXO2-like transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_03767</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0801581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AW69"/>
    <dbReference type="InParanoid" id="A0A5N4AW69"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053164">
        <property type="entry name" value="IS1016-like_transposase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47163">
        <property type="entry name" value="DDE_TNP_IS1595 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47163:SF2">
        <property type="entry name" value="SI:DKEY-17M8.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0801581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="114" mass="12690" checksum="0AE5E271F1A52659" modified="2020-02-26" version="1" fragment="single">TTTISDCWKAYDCLGEEGFRLLTVNHSYVFVDPETGSHTQNIERLWRDVRGGVPRYGRKAGHMVEYLAEFMLKRLVPSADRLHPFMQAAATLYPSSGANVEVEDSEEAGPSSAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AWF6</accession>
    <name>A0A5N4AWF6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MutL C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_03779</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0801593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AWF6"/>
    <dbReference type="OrthoDB" id="429932at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032300">
        <property type="term" value="C:mismatch repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00782">
        <property type="entry name" value="MutL_Trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.20">
        <property type="entry name" value="MutL, C-terminal domain, dimerisation subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.100">
        <property type="entry name" value="MutL, C-terminal domain, regulatory subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002099">
        <property type="entry name" value="MutL/Mlh/PMS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014790">
        <property type="entry name" value="MutL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042120">
        <property type="entry name" value="MutL_C_dimsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042121">
        <property type="entry name" value="MutL_C_regsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037198">
        <property type="entry name" value="MutL_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00585">
        <property type="entry name" value="mutl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF47">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01119">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08676">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00853">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118116">
        <property type="entry name" value="DNA mismatch repair protein MutL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein S5" evidence="4">
        <location>
            <begin position="211"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="MutL C-terminal dimerisation" evidence="3">
        <location>
            <begin position="1109"/>
            <end position="1266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0801593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1328" mass="152436" checksum="78DC74D9D2187A99" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AYH8</accession>
    <name>A0A5N4AYH8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PPYR_04406</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AYH8"/>
    <dbReference type="InParanoid" id="A0A5N4AYH8"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.370:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000063">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000003">
        <property type="entry name" value="Transposon Ty3-G Gag-Pol polyprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="9">
        <location>
            <begin position="189"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="10">
        <location>
            <begin position="745"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="979"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1023"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="980"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1042"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1057"/>
            <end position="1069"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0802220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1069" mass="121908" checksum="591E8E6AD6AECB49" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AYP3</accession>
    <name>A0A5N4AYP3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cyclase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_04466</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Cyclase 1 superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AYP3"/>
    <dbReference type="InParanoid" id="A0A5N4AYP3"/>
    <dbReference type="OrthoDB" id="7108654at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.50">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007325">
        <property type="entry name" value="KFase/CYL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037175">
        <property type="entry name" value="KFase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31118">
        <property type="entry name" value="CYCLASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31118:SF12">
        <property type="entry name" value="CYCLASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04199">
        <property type="entry name" value="Cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102198">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024385898" description="Cyclase" evidence="2">
        <location>
            <begin position="20"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0802280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="253" mass="28297" checksum="4801DD154D73BBB3" modified="2020-02-26" version="1">MKATTCLLLIITYLFQVNSNNLIDLTWPFNNVTISWGDGQKYEVTKETIIDKPDGNWYAAKEFALAEHCGTHLDAPYHFAKNGWKVDEIPLSRLIVECVKIDLSEKTAKLGHTSRLLPEDLIEWERRHGPIPPNSVILAYFNWGQFYNDREKYLGANNSASYKFPALSPEAAQWIANTNKVVGVGLDTPSVDPGGTTTKMVHKTLAENQIYGLENVKIPKDYPEKGCHLYVMPMLLAGGTGAPVRIISYLNGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-06-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B0H9</accession>
    <name>A0A5N4B0H9_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_00065</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B0H9"/>
    <dbReference type="InParanoid" id="A0A5N4B0H9"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0803095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="175" mass="19832" checksum="79A026F041AD980B" modified="2020-02-26" version="1">MTKTGGGETEVIEFTQIEEDILQTIPSTATEGIPGSIEIDTSFNFELAELPPEEISCEVDVPLVEITYDEENQPSTSTAIYHLNEDHAGMAKELPCRPNKNVRRLSKSSKLENSLKVQQNLTESYKENSQMLAEYYKVKIDYLRHKKNCDTIQTECVQKMLSILENSPVLTKKNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B1H8</accession>
    <name>A0A5N4B1H8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed DNA polymerase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_00429</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B1H8"/>
    <dbReference type="InParanoid" id="A0A5N4B1H8"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0803459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="100" mass="11431" checksum="04AFE820E9433D2F" modified="2020-02-26" version="1">MSSLARKNRDVVAIAHNSKGYDSIFILKEMMNTPSAWNPDIIATGTKITSLSSSMQLFPSATLKDRSQYHEMVAYLMQRTRYFLKKELEEAKSNIRQLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B1I6</accession>
    <name>A0A5N4B1I6_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_00220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B1I6"/>
    <dbReference type="InParanoid" id="A0A5N4B1I6"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.960.10">
        <property type="entry name" value="VSR Endonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0803250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="70" mass="7787" checksum="B268E8CA05B15D10" modified="2020-02-26" version="1">MVTAVAKLSPKGRDLVDGYSESTNIVYQFHGCYYHGCEKCHPDQTTALNGDKTDTMGMRREKTEATSARN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B5J6</accession>
    <name>A0A5N4B5J6_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_01849</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B5J6"/>
    <dbReference type="InParanoid" id="A0A5N4B5J6"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34239">
        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34239:SF2">
        <property type="entry name" value="TRANSPOSABLE ELEMENT P TRANSPOSASE_THAP9 CONSERVED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0804879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="256" mass="28433" checksum="829840C595CD58A9" modified="2020-02-26" version="1">MFQLMSSEFNPPKRDLSVAVHPAVADRWENILKSGLDAAAVATFVQKYPPAENCTFMGVPKLNPEIEAAFTEALKGRDARLSKLQGNLGAALAAIGKGLSLCLQEGEGIHFPLPLIECLSDAGRLIADCHYQHSMARRFIATSNINKSSRATLTKAPIGDWLFGDALSERVKAAKVLERASNDLKVQKVTSTQFRSKGPSSLNSKGLSRLPDNSRRGRPNFSFRRDRQPQPMLSGTKKHPVLQQRQRWQNKSRHYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B6R6</accession>
    <name>A0A5N4B6R6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb/SANT-like DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_02267</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0805297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B6R6"/>
    <dbReference type="InParanoid" id="A0A5N4B6R6"/>
    <dbReference type="OrthoDB" id="676304at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044822">
        <property type="entry name" value="Myb_DNA-bind_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47595">
        <property type="entry name" value="HEAT SHOCK 70 KDA PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47595:SF1">
        <property type="entry name" value="MYB_SANT-LIKE DNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13837">
        <property type="entry name" value="Myb_DNA-bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb/SANT-like DNA-binding" evidence="2">
        <location>
            <begin position="74"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="204"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0805297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="274" mass="31211" checksum="5A035460912D0083" modified="2020-02-26" version="1">MCSLNNFQAVVDESNNVIFKDNQILVYNPTDDCTLYIPNNEETRAALNLRETTEDNEENLTVTADDTDQHEETQRWTHESTLLLLSLYEDHIGSFKSPKKTNKSVWLRIANEMSKRGYLFTGDQCDLKFRNLKKTYKRIKDNNKSSGRGAIVWPYMDMFERVFGSAPDINPKATVSTFATSLNTLKSANLSTDNHSVVSLPYLSPSTSSVGSPGSSTQVENSNESECPEPVRNKRRKMSNEEPAWVSTLRKEAKERHDEKMTMLRELIGLLKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B742</accession>
    <name>A0A5N4B742_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">MULE transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PPYR_02356</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0805386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B742"/>
    <dbReference type="InParanoid" id="A0A5N4B742"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018289">
        <property type="entry name" value="MULE_transposase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007588">
        <property type="entry name" value="Znf_FLYWCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47160:SF10">
        <property type="entry name" value="MULE TRANSPOSASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47160">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04500">
        <property type="entry name" value="FLYWCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10551">
        <property type="entry name" value="MULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FLYWCH-type" evidence="4">
        <location>
            <begin position="4"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="MULE transposase" evidence="5">
        <location>
            <begin position="153"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0805386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="447" mass="51496" checksum="A07507561EAD92CD" modified="2020-02-26" version="1">MEVITSNKGGQKLCFGGYMYVVHKRCANNIRWRCNKYTSLKCIQGMKVRARDTLAKPIQIYAEAVQQLPNSTRAVLPTEDAIKRTLRNHKGAKFPDPQSLQELLIEGDWRTTGEPNNERFLLHDNGPNSDERVIIFATDGCLVHLANSTAWFVDGNFSLAPNLFLQLYVVRVKIQGLFVTCAYSLLQRKTQTSYEIMLRALVSSCEERNLFPDPLSINMDFERAAIQAFQAVFGDHITIRGCFYHLCQSTQRKLQELGLQRRYREDEDFSNFCGMLDGLAFLPLEDVARGMEFLRQNIPEGAEDLVEYFDATYVSGTNRRVGNVNDDNVRIRNVPPVFPPPCWNVHNTTLQDDERTNNHTEGWNHRFSTLVGQNHPTVWVLIQKMRQELSTDETKVQQRQIGRQMPKKKKPAYVVMQARLKLLCEEYRDGVRNLVDFLNAVSHNIRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B775</accession>
    <name>A0A5N4B775_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PPYR_02425</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0805455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B775"/>
    <dbReference type="InParanoid" id="A0A5N4B775"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF85">
        <property type="entry name" value="GH03217P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="9">
        <location>
            <begin position="156"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="338"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0805455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="366" mass="41961" checksum="2F6506F39F9FF41B" modified="2020-02-26" version="1">MADFMLLIFNVINNEERIRMNLNRRQLRDMSDPFSLTEETFKGIYRLSRQLTRDLMTDLSPFLQDNERVLGIPKHLKILATLNFLAQGSYQKAVGQDFFCPMSQKSVSRCVEEVTGALVEHFPHFVHFPSTAAEKTQEKQLFMTVPHGFPGIIGAVDCTHVAIISPPVEDPQYPAIVFLNRKGYYSINVQIICNARLKILAINARFPGSVHDAGIWTTSIVKNLLHTSYENGDSSSWLIGDAGYPLEPWLMTPVSGHNLTEPERRYNVAHKSIRNVIERLNGVLKTRFRCLSKHRVLHYNPAKCAKLIYACAILHNMCIHNGEIDIDIDHNDEEDNNDEPRNAENDHNNLHEGRIIRNRIIRDYFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B7S8</accession>
    <name>A0A5N4B7S8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Structural maintenance of chromosomes protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PPYR_02596</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">1611_PpyrPB1</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMC family. SMC2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0805626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B7S8"/>
    <dbReference type="FunCoup" id="A0A5N4B7S8">
        <property type="interactions" value="1870"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4B7S8"/>
    <dbReference type="OrthoDB" id="10255539at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030261">
        <property type="term" value="P:chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03273">
        <property type="entry name" value="ABC_SMC2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000278">
        <property type="entry name" value="Structural maintenance of chromosomes 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000385">
        <property type="entry name" value="Structural maintenance of chromosomes 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1060.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027120">
        <property type="entry name" value="Smc2_ABC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43977">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="7 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="15">
        <location>
            <begin position="520"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="420"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="931"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="267"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="674"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="420"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00058936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR005719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAB0805626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1170" mass="133499" checksum="2A1885AF07163361" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1JXD0</accession>
    <name>A0A1Y1JXD0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_10400</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
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        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
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        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
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            <strain evidence="3">1611_PpyrPB1</strain>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
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                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
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            <dbReference type="PubMed" id="30324905"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
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        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="4">1611_PpyrPB1</strain>
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        </source>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
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                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
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                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">1611_PpyrPB1</strain>
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        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
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            <strain evidence="17">1611_PpyrPB1</strain>
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    </reference>
    <comment type="function">
        <text evidence="10">Bifunctional mRNA-capping enzyme exhibiting RNA 5'-triphosphate monophosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation: by removing the gamma-phosphate from the 5'-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the GMP moiety of GTP to the 5'-diphosphate terminus of RNA via a covalent enzyme-GMP reaction intermediate.</text>
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    <comment type="catalytic activity">
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            <text>a 5'-end diphospho-ribonucleoside in mRNA + GTP + H(+) = a 5'-end (5'-triphosphoguanosine)-ribonucleoside in mRNA + diphosphate</text>
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            <dbReference type="ChEBI" id="CHEBI:167617"/>
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        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:67013"/>
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    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a 5'-end triphospho-ribonucleoside in mRNA + H2O = a 5'-end diphospho-ribonucleoside in mRNA + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67004"/>
            <dbReference type="Rhea" id="RHEA-COMP:17164"/>
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            <dbReference type="ChEBI" id="CHEBI:167618"/>
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        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">In the C-terminal section; belongs to the eukaryotic GTase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">In the N-terminal section; belongs to the non-receptor class of the protein-tyrosine phosphatase family.</text>
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                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
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                <person name="Debat H.J."/>
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                <person name="Suvorov A."/>
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                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:RNA 3'-end processing"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054708">
        <property type="entry name" value="MTPAP-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002058">
        <property type="entry name" value="PAP_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271">
        <property type="entry name" value="POLY A POLYMERASE CID PAP -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271:SF40">
        <property type="entry name" value="POLY(A) RNA POLYMERASE GLD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22600">
        <property type="entry name" value="MTPAP-like_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03828">
        <property type="entry name" value="PAP_assoc"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Nucleotidyltransferase"/>
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        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly(A) RNA polymerase mitochondrial-like central palm" evidence="10">
        <location>
            <begin position="220"/>
            <end position="357"/>
        </location>
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        <location>
            <begin position="444"/>
            <end position="505"/>
        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF22600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="JAV55715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAB0802132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="548" mass="63268" checksum="2824A7D4F192DA23" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1K8S3</accession>
    <name>A0A1Y1K8S3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA-directed RNA polymerase III subunit RPC9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">DNA-directed RNA polymerase III subunit rpc9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PPYR_01148</name>
        <name evidence="16" type="ORF">PPYR_13532</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16 18" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">1611_PpyrPB1</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">1611_PpyrPB1</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Accessory protein for the calcitonin gene-related peptide (CGRP) receptor. It modulates CGRP responsiveness in a variety of tissues.</text>
    </comment>
    <comment type="function">
        <text evidence="12">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III (Pol III) which synthesizes small non-coding RNAs including 5S rRNA, snRNAs, tRNAs and miRNAs from at least 500 distinct genomic loci. With POLR3H/RPC8 forms a mobile stalk that protrudes from Pol III core and functions primarily in transcription initiation. Pol III plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF-kappa-B through the RIG-I pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the RNA polymerase III complex consisting of 17 subunits: a ten-subunit horseshoe-shaped catalytic core composed of POLR3A/RPC1, POLR3B/RPC2, POLR1C/RPAC1, POLR1D/RPAC2, POLR3K/RPC10, POLR2E/RPABC1, POLR2F/RPABC2, POLR2H/RPABC3, POLR2K/RPABC4 and POLR2L/RPABC5; a mobile stalk composed of two subunits POLR3H/RPC8 and CRCP/RPC9, protruding from the core and functioning primarily in transcription initiation; and additional subunits homologous to general transcription factors of the RNA polymerase II machinery, POLR3C/RPC3-POLR3F/RPC6-POLR3G/RPC7 heterotrimer required for transcription initiation and POLR3D/RPC4-POLR3E/RPC5 heterodimer involved in both transcription initiation and termination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic RPC9 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01096056">
        <property type="protein sequence ID" value="JAV55177.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1K8S3"/>
    <dbReference type="InParanoid" id="A0A1Y1K8S3"/>
    <dbReference type="OrthoDB" id="1746530at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.40:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase III subunit RPC9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006590">
        <property type="entry name" value="RNA_pol_Rpb4/RPC9_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005574">
        <property type="entry name" value="Rpb4/RPC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038324">
        <property type="entry name" value="Rpb4/RPC9_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038846">
        <property type="entry name" value="RPC9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15561">
        <property type="entry name" value="CALCITONIN GENE-RELATED PEPTIDE-RECEPTOR COMPONENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15561:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03874">
        <property type="entry name" value="RNA_pol_Rpb4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00657">
        <property type="entry name" value="RPOL4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="HRDC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase Rpb4/RPC9 core" evidence="14">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00043924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00073026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="JAV55177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAB0793912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAB0804178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="134" mass="15480" checksum="E32E314C0A32F844" modified="2017-08-30" version="1">MEVINSNSAQLSNYEVLKHLQQLKDGRKKDKRQGQLATITYETLRYLENTPCNQQTPETITACLKALEPFNLSKNEKLMIINSPPTTALEIQLMIEESEERLTEEQVNEILKIVVLHFPHVQKVEENEDETEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1KDM1</accession>
    <name>A0A1Y1KDM1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PPYR_08387</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01087847">
        <property type="protein sequence ID" value="JAV58441.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1KDM1"/>
    <dbReference type="InParanoid" id="A0A1Y1KDM1"/>
    <dbReference type="OrthoDB" id="2962993at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF149">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="5">
        <location>
            <begin position="34"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="6">
        <location>
            <begin position="445"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="JAV58441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0797393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="537" mass="61938" checksum="6AAEB3C30D4A933A" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1KHM9</accession>
    <name>A0A1Y1KHM9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PPYR_12064</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Trehalose transporter subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01083852">
        <property type="protein sequence ID" value="JAV60972.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0795225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1KHM9"/>
    <dbReference type="InParanoid" id="A0A1Y1KHM9"/>
    <dbReference type="OrthoDB" id="4540492at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000055">
        <property type="entry name" value="Facilitated trehalose transporter Tret1-2 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050549">
        <property type="entry name" value="MFS_Trehalose_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021:SF46">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="247"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="311"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="345"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="381"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="410"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="1"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="JAV60972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0795225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="481" mass="52289" checksum="D3358FFD27D3C853" modified="2017-08-30" version="1">MALISGRLCQVLAVITGTLTVISDGMHYGWSSPIVPLLQSPQSPIPISESDVLWLENCLMFGGIAGLFLTMYLLDKVGRKRTMLIAAVENLIAWVLIATATTPEVLLVARFISGIAADVNFVAAPVYIAEIADKEIRGRLSSLINIFSLLGVVLIYSVGPFVSITISSAIGMGFLVTELLTFSSMPESPHYLLVRQKPEAARESLKVLRNVDVDDELRELTEVVERENACRGRPFDLIKVKSYRKAILIMTVLNFGQHFTGLSVMIMNLHIILEEAGSSIKTNTAAIEFSLLMVAACIITMFLIDLLGRRVLLTTSSVLTGISLLVLGVYFAIKNAGGNTRDYTWIPVASLMVYAIVHKIGLGSIPIVVTAELFPTNIKAVGCTVADSIYVIASASSIFVFHYMLRQFGMHAPIFLFAACSILVGLFVIFFLPETKGKTLEQIQQMLKGESDANSETTKLLSPVGETDEDYGAVINTQAGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1KI00</accession>
    <name>A0A1Y1KI00_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Testicular haploid expressed gene protein-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_12439</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01085975">
        <property type="protein sequence ID" value="JAV59860.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0795600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1KI00"/>
    <dbReference type="InParanoid" id="A0A1Y1KI00"/>
    <dbReference type="OrthoDB" id="25466at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042401">
        <property type="entry name" value="SPMAP2-like"/>
    </dbReference>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAB0795600.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="336" mass="38286" checksum="132B8497115B145C" modified="2017-08-30" version="1">MVLPASERPDRLRTILLAYPTRVTKKYVPPVYTGKVFTGVRPSAVRGRPKQNWRLNKLAIPNRTVPKYVFVEEKGTGIRPSALTVNITQRMDDMSKPTLRYLYQARKAYSELGPRIKKNLQKTINQSWKTIYNYYRKQMIDIKRKKDMRLAKQKELATKTVVKTKTPKELKEEKEKRIAAWCAVKAQPKKSFPPPPLPVQKRPAATLNEIIVHANILAEPRSVTVKFIRPSIDPTYIDPTRVKPAAKTYVASERVLELAKNPAHRLLKERPIVPGAVKKSALTCAVSPRFDELAVPKKKAAEKDSDLKENPFQISPNALKAKTTARIKELAKPIER</sequence>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
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                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
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            <dbReference type="DOI" id="10.1038/srep38556"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
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            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
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                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </reference>
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    </evidence>
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        <source>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
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                <person name="Fallon T.R."/>
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            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Photinus pyralis genome working group"/>
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                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
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                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="3" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
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        <property type="molecule type" value="Transcribed_RNA"/>
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    <dbReference type="InParanoid" id="A0A1Y1L5Z0"/>
    <dbReference type="OrthoDB" id="6435011at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41142">
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    <proteinExistence type="predicted"/>
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    <feature type="compositionally biased region" description="Basic residues" evidence="1">
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
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        </source>
    </evidence>
    <sequence length="262" mass="29568" checksum="3C1C9C6784F4C831" modified="2017-08-30" version="1">MLKFLTHKLRTHSINEDNFTEKADEDHDSGTESDDEIEDSELSGPVMSERMCSVSPADTGCSVESPAPDHQHDPHSSEEELEVINSSKQTRPDRTPRAASVCLPEKRKWSQIGDSYARRYSPENEENMSHYGNLTPSSPCSPYGNKHYGDDAVHLEHSGSSDDEVHHLLASMATPVQFRTSPPLEAVKPGGRILNSKIRSLSPPPKLVHYEVSPRKRSRHTRHLHLQRPCLDFEKMQQLKARSVTPWRNNSDHGGELSVFCW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LED3</accession>
    <name>A0A1Y1LED3_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_11227</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01063015">
        <property type="protein sequence ID" value="JAV69377.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01063012">
        <property type="protein sequence ID" value="JAV69383.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01063011">
        <property type="protein sequence ID" value="JAV69387.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01063009">
        <property type="protein sequence ID" value="JAV69391.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01063008">
        <property type="protein sequence ID" value="JAV69394.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01063007">
        <property type="protein sequence ID" value="JAV69396.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01063005">
        <property type="protein sequence ID" value="JAV69402.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01063003">
        <property type="protein sequence ID" value="JAV69407.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01063002">
        <property type="protein sequence ID" value="JAV69412.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0794388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1LED3"/>
    <dbReference type="InParanoid" id="A0A1Y1LED3"/>
    <dbReference type="OrthoDB" id="6226069at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="JAV69387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0794388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="350" mass="40822" checksum="2F90580DE761C55E" modified="2017-08-30" version="1">MKVLRRIKSLPEYECNSKKCNDAKITLEEFDSQPIYFKSVIRPMLAIGHEGELVIWLKNIGILQHSQRCNNLIDNMECQGVMNWMPAKIIDQYQWKCKKCPKKRNIREQSVFQDVKCRFKDIVRILAGWCKGTDVEALTKLLCVKKQAVNAVYNVAASVAHKYIQTNLSRWQLGGPGTIVLIESYPEGFKELNSQEHFQNHIIPLICIAEIKEIPTRFWLQVLDRYNPNVQEQVQNANTVALHIIQEIVLPGSILVTNIDSKICSFDVLQSLKHLYPVIISKDGLKRHDHLNVLLDNFETIWFPALRICNEAQYYSNAHIQNFITNFLWRQKFENESFENLLHQMCYNFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LFQ8</accession>
    <name>A0A1Y1LFQ8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glucosidase II subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PPYR_14276</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">1611_PpyrPB1</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">1611_PpyrPB1</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; N-glycan metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01057065">
        <property type="protein sequence ID" value="JAV72464.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1LFQ8"/>
    <dbReference type="FunCoup" id="A0A1Y1LFQ8">
        <property type="interactions" value="1778"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1LFQ8"/>
    <dbReference type="OrthoDB" id="3237269at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090599">
        <property type="term" value="F:alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006491">
        <property type="term" value="P:N-glycan processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06603">
        <property type="entry name" value="GH31_GANC_GANAB_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14752">
        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000039">
        <property type="entry name" value="Glucosidase, alpha neutral C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1180:FF:000023">
        <property type="entry name" value="neutral alpha-glucosidase AB isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030458">
        <property type="entry name" value="Glyco_hydro_31_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF54">
        <property type="entry name" value="BCDNA.GH04962"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00129">
        <property type="entry name" value="GLYCOSYL_HYDROL_F31_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033750358" description="Glucosidase II subunit alpha" evidence="11">
        <location>
            <begin position="20"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 N-terminal" evidence="13">
        <location>
            <begin position="76"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="12">
        <location>
            <begin position="355"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="14">
        <location>
            <begin position="690"/>
            <end position="779"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00042895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="JAV72464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAB0792317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="914" mass="103867" checksum="32A7C6E3B02DC05F" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LFZ3</accession>
    <name>A0A1Y1LFZ3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">LRRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_11597</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
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            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
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        <property type="protein sequence ID" value="JAV72544.1"/>
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    </dbReference>
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        <property type="entry name" value="Ribonuclease Inhibitor"/>
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        <property type="entry name" value="Leu-rich_rpt"/>
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        <property type="entry name" value="ANTIGEN BSP, PUTATIVE-RELATED"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="485" mass="54657" checksum="F77BBCA6362AAA5C" modified="2017-08-30" version="1">MARERAVTWAWAVLSGLCALASCQVQQQCPARQEIAPCSCQMKKNGLDILCEFTDQQHIDNAMSVLKGKSLVIFYLKLRHNNLKKLPGFVFFGLDIRHLTIHNSSLSVVEEASLSSIGKMLTQLDVSQNSLTSVPSAAYKNLHHLLILNMNHNNINSIPNRAFQGLDTLEILTLYENKITTVEPDAFVGLEKRLKRLNLGGNELTSVPQKSLSILDTLKKLEMQENQISRIQEGDFEGMKNLDSLGLAHNKLREVPARAFSHLSQLNSLELDGNNIVLVDPSAFAGLEENLQYLRLGDNNIHTIPTPALRGLHRLRHLDLRANNISYIAEDAFTGYGDSITFLNLQKNDIKMLPALGFENLNSLETLNLQNNKIMHIPEEVMEAVTDTLRVVDVTDNPLVCDCELQWYKNWIRNLRDKDDEMMQKKRTVCIMTSEHREYSLQSLPLDKMHCAVKAYDPINSRSTSLLTSSFATLCLGLYTVKCVI</sequence>
</entry>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
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                <person name="Fallon T.R."/>
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            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
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        <property type="molecule type" value="Transcribed_RNA"/>
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        </location>
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            <end position="178"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAB0792996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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        </source>
    </evidence>
    <sequence length="178" mass="20052" checksum="F014A8DB1DD6AEB3" modified="2017-08-30" version="1">MNMILLGLILLWSVHLVSSSKIEDHFFRDYYGLVPTDAIPGGKTEDGGMTYIGQFPVLNYFEDLRIDLLTATIVKGELRAYGPYNNRTVYSDDVNVKILCAKYPTEYKWYSPTQSYPPKCRYVTVGYEGTDLFVGKATVGRQEVLGKIFSNSTNRLIIPFNGGESYPSSYTVLTYCSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="10">Farnesyl diphosphate synthase</fullName>
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        <name evidence="8" type="ORF">PPYR_00207</name>
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    <organism evidence="7">
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            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
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            <taxon>Elateroidea</taxon>
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    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
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                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
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            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
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    <reference evidence="8" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
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        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Pheromone biosynthesis.</text>
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        <text evidence="6">Belongs to the FPP/GGPP synthase family.</text>
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        <property type="molecule type" value="Transcribed_RNA"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:dimethylallyltranstransferase activity"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042811">
        <property type="term" value="P:pheromone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039702">
        <property type="entry name" value="FPS1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11525:SF0">
        <property type="entry name" value="FARNESYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11525">
        <property type="entry name" value="FARNESYL-PYROPHOSPHATE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="JAV74964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0803237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="410" mass="47486" checksum="34B5841C28123702" modified="2017-08-30" version="1">MNIISTNPNVMHWILYAKPWNCSKLWEKLKGAGSIARGHCDKWNQHSKPSAPKMDWITEEDRGEFLKMFPSLVKELKSDKMLYGHSDVAERFGKFLEHTVPHGKLLNSLTFVAFYKLIEDPARLTPQNVHLSMILGWCVQLLVTVFTVSDDMIDFSETRRGRRCWHLLEDVGMSAINDVMFVKSGIFSILRNHLRDHHCYLPTMELFQRYIGQLAMGQTNDTISMVKVDLLDQNTFNIDNYKATIKFKAGLLFSFPLHLAMHLSSKRDYKLLKQVDEIFIKIGSYFQSQNDFFDGFVDHSITGKHGTDIQEGKISWLILHAMLLASSTQKDILLQNYGKGHTKNKAAVLAVYKDLDLPKVYAQFEDDTYNELKYDIQMISETSVQTFCLKVLDSIYKRYMRQYHQQLSAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LMV8</accession>
    <name>A0A1Y1LMV8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PPYR_04886</name>
        <name evidence="11" type="ORF">PPYR_08181</name>
        <name evidence="10" type="ORF">PPYR_11953</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10 13" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01054395">
        <property type="protein sequence ID" value="JAV73681.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01054394">
        <property type="protein sequence ID" value="JAV73684.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01054393">
        <property type="protein sequence ID" value="JAV73687.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01054392">
        <property type="protein sequence ID" value="JAV73690.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01054391">
        <property type="protein sequence ID" value="JAV73692.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01054390">
        <property type="protein sequence ID" value="JAV73695.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01054389">
        <property type="protein sequence ID" value="JAV73700.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01054388">
        <property type="protein sequence ID" value="JAV73701.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0795114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1LMV8"/>
    <dbReference type="InParanoid" id="A0A1Y1LMV8"/>
    <dbReference type="OrthoDB" id="6767039at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF85">
        <property type="entry name" value="GH03217P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="8">
        <location>
            <begin position="157"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="JAV73690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0795114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0797187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAB0802700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="370" mass="42616" checksum="4108AB1AB6D150D9" modified="2017-08-30" version="1">MDQDYLLLLHMLQQADERYQVNLRRRTLRDASNPMTMPESTFMSVFRLSRELAQDVIDELSPHLRQERGPTPIPIYLRILVALHFYGQGSYQKGVGKDYHLAMSQSSVSRCIAEVTDAINEVMVDRVNFPTTFQQKNAEKLKFAQILHGFPGIIGAIDCTHVAIQSPPVHHPEYPAIVFYNRKGYYSINTQIICSADLKILNVNARFPGSVHDSAIWTTSAIYQHLRDAYNNGDTGSWLIGDSGYPLQPWLMTPLGGQGLTPQEQRYNVIHKRCRNVIERLNGVLKGRFRCLLRHRTLHYSPLRAAKIINACCILHNLCIERRLENNEEWPNEEDEIVEDNFNNIPQQEQGNVLHIGRITRRRIIDNYIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LRP3</accession>
    <name>A0A1Y1LRP3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Mitochondrial potassium channel ATP-binding subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">ATP-binding cassette sub-family B member 8, mitochondrial</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Mitochondrial sulfonylurea-receptor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">PPYR_00528</name>
    </gene>
    <organism evidence="21">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="22 23" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">1611_PpyrPB1</strain>
            <tissue evidence="22">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">1611_PpyrPB1</strain>
            <tissue evidence="22">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01050589">
        <property type="protein sequence ID" value="JAV75508.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1LRP3"/>
    <dbReference type="FunCoup" id="A0A1Y1LRP3">
        <property type="interactions" value="125"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1LRP3"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18574">
        <property type="entry name" value="ABC_6TM_ABCB8_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0630">Potassium</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="157"/>
            <end position="175"/>
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    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="234"/>
            <end position="252"/>
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    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="258"/>
            <end position="278"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="346"/>
            <end position="366"/>
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    </feature>
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        <location>
            <begin position="110"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="19">
        <location>
            <begin position="434"/>
            <end position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00007577"/>
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            <dbReference type="ARBA" id="ARBA00022448"/>
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        <source>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00040439"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00041416"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00042968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="JAV75508.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAB0803558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="676" mass="74827" checksum="1E2A2EA1875A7173" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LYF0</accession>
    <name>A0A1Y1LYF0_PHOPY</name>
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        <recommendedName>
            <fullName evidence="4">Ribosomal protein L19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PPYR_05653</name>
        <name evidence="9" type="ORF">PPYR_05654</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
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        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
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        </source>
    </reference>
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        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL19 family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:structural constituent of ribosome"/>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF01280">
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Ribosomal_L19e"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF48140">
        <property type="entry name" value="Ribosomal protein L19 (L19e)"/>
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    </dbReference>
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    <feature type="domain" description="Large ribosomal subunit protein eL19" evidence="6">
        <location>
            <begin position="3"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="71"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011082"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000574"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM01416"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="JAV76706.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAB0801299.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAB0801300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="200" mass="23700" checksum="B55F61B7C9572B76" modified="2017-08-30" version="1">MSSLKLQKRLAASVMRCGEKKVWLDPNEINEIANTNSRQNIRKLIKDGLIIKKPVAVHSRARVRKNTEARRKGRHCGFGKRKGTANARMPQKELWIQRMRVLRRLLKKYREAKKIDRHLYHSLYMKAKGNVFKNKRVLMEYIHKKKAEKARTKSLHDQAEARRLKVKEARKRREERIALKKQEIIQNYQKEDEAAAAARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1M205</accession>
    <name>A0A1Y1M205_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_07977</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051866">
        <property type="entry name" value="Intracell_Sig-Traffick_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007330">
        <property type="entry name" value="MIT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036181">
        <property type="entry name" value="MIT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15508:SF8">
        <property type="entry name" value="LD24550P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15508">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04212">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116846">
        <property type="entry name" value="MIT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PX" evidence="2">
        <location>
            <begin position="5"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="349"/>
            <end position="714"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="JAV79460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0804546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="729" mass="83330" checksum="E510C6E45F46587E" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1M623</accession>
    <name>A0A1Y1M623_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_09733</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01039739">
        <property type="protein sequence ID" value="JAV81242.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01039734">
        <property type="protein sequence ID" value="JAV81249.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0795672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1M623"/>
    <dbReference type="InParanoid" id="A0A1Y1M623"/>
    <dbReference type="OrthoDB" id="6361347at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018713">
        <property type="entry name" value="MPAB/Lcp_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37159">
        <property type="entry name" value="GH11867P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37159:SF1">
        <property type="entry name" value="GH11867P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09995">
        <property type="entry name" value="MPAB_Lcp_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="314"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic" evidence="2">
        <location>
            <begin position="62"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="JAV81242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0795672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="352" mass="41138" checksum="6DE19E55C8EDC24B" modified="2017-08-30" version="1">MQTVHQDHCKKLRDDLSTQETIKLIQEDCTSICDDSYQEFEDRQTLPPFYDEEKFKKGQEFYHKHVLAMFVAKLFGLLTVISTPTILKILTFTNMSSTPLTAYKRYLATVYHMCVWYDNDFKPGSKLWDSINKVKMMHCSASRRHCVAGGQRILQRDMGITQFGFMGFAILTPEKVGIHNATREELESFIHLWRVIGYIMGADDKYNICKGTLEETREICEGLVNNIFIDNVKTKNANYQRLADALVNGMWAMQPFLEPTAFKTYLANLLSSVSNNNLEIPTVPLNLFQYFIFYGLQAYIFSLQFHYMRIFANFLQYLSFWLMHHFPFLAFYSYGYKNSFVAIFKERLGKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1M8A9</accession>
    <name>A0A1Y1M8A9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mannosyltransferase</fullName>
            <ecNumber evidence="12">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PPYR_01543</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">1611_PpyrPB1</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">1611_PpyrPB1</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Mannosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the eighth mannose residue in an alpha-1,6 linkage onto Man(7)GlcNAc(2)-PP-dolichol to produce Man(8)GlcNAc(2)-PP-dolichol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate = an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29535"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="Rhea" id="RHEA-COMP:19518"/>
            <dbReference type="Rhea" id="RHEA-COMP:19519"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:132517"/>
            <dbReference type="ChEBI" id="CHEBI:132519"/>
            <dbReference type="EC" id="2.4.1.260"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:29536"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the glycosyltransferase 22 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="12"/>
    <dbReference type="EMBL" id="GEZM01039726">
        <property type="protein sequence ID" value="JAV81258.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1M8A9"/>
    <dbReference type="FunCoup" id="A0A1Y1M8A9">
        <property type="interactions" value="952"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1M8A9"/>
    <dbReference type="OrthoDB" id="19039at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052917">
        <property type="term" value="F:dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005599">
        <property type="entry name" value="GPI_mannosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760:SF1">
        <property type="entry name" value="DOL-P-MAN:MAN(7)GLCNAC(2)-PP-DOL ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03901">
        <property type="entry name" value="Glyco_transf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
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    </evidence>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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</entry>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
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        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
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                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
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            <dbReference type="PubMed" id="30324905"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
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        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="4">1611_PpyrPB1</strain>
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        </source>
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</entry>
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            <dbReference type="DOI" id="10.1038/srep38556"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
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            <authorList>
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                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
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            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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            <tissue evidence="12">Whole body</tissue>
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    <reference evidence="12" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="12">1611_PpyrPB1</strain>
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        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        </source>
    </evidence>
    <sequence length="305" mass="34849" checksum="CB500B4307C7FE89" modified="2017-08-30" version="1">MGTLSILYNKQRELCSQCSSGTMYRSSTVFNKSLFKQILTNLRNVYKSSNNGQEQQIKIAGQTINYLKKGNGPQTILCFPGAFGTIWTDFTPQIEELDTKKFTVVVWDPPGYGKSRPPQRTFTNDFYIKDADMAAKLMKELHIDKYSLLGWSDGGNSSMILSSMYPNCVDNLVIWGSNSKILPDDITACEKIRDINSWSEKMKRPFIKMYGDEFQTLINNWLDALHNIAKEGGNICHDMLPSIKCPTLILHGNKDAMIAEEHPDILLKNIKNSKIHRFPEGKHNIHLRYSQEFNAVVSRFIEEHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1MRS7</accession>
    <name>A0A1Y1MRS7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA-directed RNA polymerase I subunit RPA43</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">DNA-directed RNA polymerase I subunit F</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Twist neighbor protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PPYR_09758</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPA43 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01023394">
        <property type="protein sequence ID" value="JAV88412.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0795697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1MRS7"/>
    <dbReference type="FunCoup" id="A0A1Y1MRS7">
        <property type="interactions" value="378"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1MRS7"/>
    <dbReference type="OrthoDB" id="10250504at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.120:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase I subunit RPA43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="entry name" value="RNA polymerase Rpb7-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041178">
        <property type="entry name" value="RPA43_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045113">
        <property type="entry name" value="Rpb7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005576">
        <property type="entry name" value="Rpb7-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709:SF5">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II, III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17875">
        <property type="entry name" value="RPA43_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03876">
        <property type="entry name" value="SHS2_Rpb7-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase Rpb7-like N-terminal" evidence="11">
        <location>
            <begin position="34"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="RPA43 OB" evidence="12">
        <location>
            <begin position="102"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="186"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="219"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="296"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00073455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00080323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00083123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="JAV88412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAB0795697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="351" mass="40214" checksum="AFA6A0610CE914CC" modified="2017-08-30" version="1">MHKTQRIISFQIEYLNSLVADETSSVIVQEQQYHLALHPYHLNNIKQSIKDLLSQKIARYDQKLGGILLGFENTKLLTEGVIMNDSCFIHIDVSANFFIFKPEVGQILVGVVNKKSKDHVGCLLYNTFNVSLPKPEDQDVESWSGTYSEIGNEIKFRITFMKLQARLPYIRGQLIDEDSPKRKKNKILTVVAEETPTTSKKKKKKKDVDLDEEYLPNGFGSSESSIKTEINDTSVKESKKRKRESMEESPKKKKKLEQMEDGHKKSKRKKSINENEFNINEKLKQENDSELSDTPNLDIDISIDNLISNELSNRSHKKKKRNKGDTLEVVGDADSLGQNTVISKKKRKRAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1MUA7</accession>
    <name>A0A1Y1MUA7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PPYR_04919</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01020562">
        <property type="protein sequence ID" value="JAV89252.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1MUA7"/>
    <dbReference type="FunCoup" id="A0A1Y1MUA7">
        <property type="interactions" value="559"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1MUA7"/>
    <dbReference type="OrthoDB" id="199599at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006846">
        <property type="entry name" value="Ribosomal_eS30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12650">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S30/UBIQUITIN-LIKE PROTEIN FUBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12650:SF15">
        <property type="entry name" value="RIBOSOMAL PROTEIN S30, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04758">
        <property type="entry name" value="Ribosomal_S30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="4">
        <location>
            <begin position="8"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="80"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="JAV89252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0802733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="131" mass="14525" checksum="2C9B18552C748481" modified="2017-08-30" version="1">MQLHIRGQSVHVLECQGTETFAQIKNRIAALEELTPEDIKLYSQGNPISEDALVSLYEAADIELNVGLLGGKVHGSLARAGKVKGQTPKVEKQEKKKKKTGRAKRRIQYNRRFINVVATFGRKRGPNSNSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1N594</accession>
    <name>A0A1Y1N594_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Zinc transporter 2-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PPYR_00254</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">1611_PpyrPB1</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">1611_PpyrPB1</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
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        <reaction evidence="12">
            <text>Zn(2+)(in) + 2 H(+)(out) = Zn(2+)(out) + 2 H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:72627"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Secretory vesicle membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
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            <dbReference type="Pfam" id="PF01545"/>
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        <source>
            <dbReference type="EMBL" id="KAB0803284.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="393" mass="43401" checksum="FAAD9410AB478625" modified="2017-08-30" version="1">MDIYCDHSHESDYDDDKLLLDDENTNHDSCNKCRAKFTSTSGFVKPVLNDRASVTVVDDMNVDLPQLMNGHSTELHDFHCHKRVKVYDDQKAWKKLISVSLLCFFFMLTELIGGYLAGSLAVMTDAAHLFSDLIGFFVSLISIWIGKKAPTRVMTFGYHRAEVLGAFLSVLAVWLLAGIFCVVAVGRLLHKEYEIDVDTMLIVASIGVVVNILMGAVLHGMCHTHSHTGAVHAHHGENINVRAAAAHIIGDLLQSIGVLIAAVIIKVFPNAQVADPICTLLFSVIVVYATLRVAHDAIKILLEASPKHAGDLKMQFTKISSVKHVHEVHVWSLAPGKEAVTVHLAVDQDCDRDFVLKQATCIIRNELNAVSCTIQIEKYNQELIQLCSDCQNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
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    <name>A0A1Y1N6Q8_PHOPY</name>
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        <name evidence="4" type="ORF">PPYR_11099</name>
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        <lineage>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
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                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
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            <dbReference type="PubMed" id="30324905"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
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    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01016403">
        <property type="protein sequence ID" value="JAV91287.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KAB0797038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A1Y1N6Q8"/>
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    </dbReference>
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        <property type="entry name" value="DUF4806"/>
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        <property type="entry name" value="SI:CH211-262H13.3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        </location>
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            <begin position="173"/>
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        </location>
    </feature>
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        </source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="365" mass="41465" checksum="449B3736D96BF0E8" modified="2017-08-30" version="1">MSYSVVEFSDGVQVVPTSWIFKECNIDMCWWPPNCNDKFQINRLVSGNHNPESNWKKHKLLKIFCQTPTYEKGKEKLEYALLLSDVEVEDDAVKRSRHQRHCSKRDAACVDTDEAHSKSNKKRLRVIYESDEESSTGSDTKLTQMPPFPPIPSLLSRLRETEDNGPEKADGSDVSTGVSTPVSRGDFEPGGATDINRKLNLILHKLHVIENRLNTLDSVQQSQTVQLTKTVQDLYKIFPLGSHEELDNFEKELEGETYFKKMVSEFTTIGGHDVQSLTVNILKKLLSNKVAVEYSLQGKKKKKIFKNLLSYQMIISAVRYHKSCATEVDISGCIATWLSQSGLRMAREINKRLPAEQLMVEPTPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1NEF4</accession>
    <name>A0A1Y1NEF4_PHOPY</name>
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        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    <organism evidence="7">
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    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
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                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CAND family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01005504">
        <property type="protein sequence ID" value="JAV96129.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000003">
        <property type="protein sequence ID" value="KAB0801421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1NEF4"/>
    <dbReference type="FunCoup" id="A0A1Y1NEF4">
        <property type="interactions" value="1959"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1NEF4"/>
    <dbReference type="OrthoDB" id="6260732at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010265">
        <property type="term" value="P:SCF complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039852">
        <property type="entry name" value="CAND1/CAND2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057546">
        <property type="entry name" value="HEAT_GCN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013932">
        <property type="entry name" value="TATA-bd_TIP120"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12696">
        <property type="entry name" value="TIP120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23271">
        <property type="entry name" value="HEAT_GCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08623">
        <property type="entry name" value="TIP120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25782">
        <property type="entry name" value="TPR_CAND1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Stalled ribosome sensor GCN1-like HEAT repeats region" evidence="6">
        <location>
            <begin position="150"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="TATA-binding protein interacting (TIP20)" evidence="5">
        <location>
            <begin position="1041"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="312"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="JAV96129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0801421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1233" mass="139482" checksum="FB4EDFC0EB2D15C5" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1NEQ6</accession>
    <name>A0A1Y1NEQ6_PHOPY</name>
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        <recommendedName>
            <fullName evidence="11">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="11">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PPYR_03626</name>
        <name evidence="17" type="ORF">PPYR_09148</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16 18" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">1611_PpyrPB1</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">1611_PpyrPB1</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="11"/>
    <dbReference type="EMBL" id="GEZM01005593">
        <property type="protein sequence ID" value="JAV96068.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1NEQ6"/>
    <dbReference type="InParanoid" id="A0A1Y1NEQ6"/>
    <dbReference type="OrthoDB" id="10261556at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18015">
        <property type="entry name" value="DEXHc_RecQ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18794">
        <property type="entry name" value="SF2_C_RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001544">
        <property type="entry name" value="ATP-dependent DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001975">
        <property type="entry name" value="ATP-dependent DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004589">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032284">
        <property type="entry name" value="RecQ_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00614">
        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF105">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE Q1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16124">
        <property type="entry name" value="RecQ_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="90"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="287"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="2"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="JAV96068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAB0791826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAB0798155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="606" mass="68968" checksum="F7F951C2BBE58A73" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1NKP7</accession>
    <name>A0A1Y1NKP7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Regucalcin</fullName>
            <ecNumber evidence="7">3.1.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Gluconolactonase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PPYR_04817</name>
        <name evidence="18" type="ORF">PPYR_11978</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18 20" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">1611_PpyrPB1</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">1611_PpyrPB1</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-glucono-1,5-lactone + H2O = D-gluconate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10440"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16217"/>
            <dbReference type="ChEBI" id="CHEBI:18391"/>
            <dbReference type="EC" id="3.1.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="15">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the SMP-30/CGR1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.17" evidence="7"/>
    <dbReference type="EMBL" id="GEZM01003649">
        <property type="protein sequence ID" value="JAV96656.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01003648">
        <property type="protein sequence ID" value="JAV96657.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0795139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1NKP7"/>
    <dbReference type="FunCoup" id="A0A1Y1NKP7">
        <property type="interactions" value="187"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1NKP7"/>
    <dbReference type="OrthoDB" id="423498at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004341">
        <property type="term" value="F:gluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019853">
        <property type="term" value="P:L-ascorbic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000027">
        <property type="entry name" value="Regucalcin homologue"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013658">
        <property type="entry name" value="SGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005511">
        <property type="entry name" value="SMP-30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10907:SF66">
        <property type="entry name" value="MIP34848P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10907">
        <property type="entry name" value="REGUCALCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08450">
        <property type="entry name" value="SGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01790">
        <property type="entry name" value="SMP30FAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="SMP-30/Gluconolactonase/LRE-like region" evidence="16">
        <location>
            <begin position="16"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="14">
        <location>
            <position position="214"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00008853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00016808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR605511-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR605511-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF08450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="JAV96656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAB0795139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAB0802631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="310" mass="34497" checksum="CB9F663908527F7C" modified="2017-08-30" version="1">MAPVIEKIRELGCFELGEGPHWDNESQSLYWVDIVKKTIHKYIPSLKKHTHIKVDKFPSLIVPISGSSDRFIITLQREVAVLTWDGVSSRPTSIETIAIVDTDNALKNNRINDGKVDPLGNLWAGTMAIDGDTPYGPRTGTLFCLSSNKKIRYFEENVGISNGLAWSSDLKKMYYIDSVKRRIDQYDFDATNASITNRQPLFSLEKHNIPGFPDGQTIDADGNLWVAVFRGKRVIKVSSAKPETLLDTVNIPDLQITSVAFGGPLLDELYVTSASHIAWPTEGEEDCIKGHIYKITGLGVRGLPANRIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N3ZYT2</accession>
    <name>A0A5N3ZYT2_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zinc finger PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PPYR_15450</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01001666">
        <property type="protein sequence ID" value="KAB0790217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N3ZYT2"/>
    <dbReference type="InParanoid" id="A0A5N3ZYT2"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15517">
        <property type="entry name" value="PHD_TCF19_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger PHD-type" evidence="5">
        <location>
            <begin position="460"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="412"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="430"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0790217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="508" mass="56193" checksum="AC7F175527620EA4" modified="2020-02-26" version="1">MCVTPPTREQEHHVAATFPENGTPIVNLKRRVTLASGALYRSEVQSKGIGIIGTLTGHTAVDPVEFVEPKTFSSSEQGGAHLLFEGVSQIVSPTPYPEYYSFVWFNLIEPLAEASPLFNVGFVNQRHSNLALQSLWLDADRNFFPKWFEHFLHYSKPSATDPVLLILDGHATHTKNVQLIEAARQNHVHILCIPPHTSHRLQPLDVSFMFPLSTFHTQECETWMRQNPGRAITIRQVGSIFGKSYLKASTPQNAINGFKKTGIFPLDPNVFPEEAFAASETTDRDLDADAVTIQDAVFHATENPVVDKTSSSTTNVMQDINVSPITVDSNCASCSNVSSSSPTQTIPPDSNVASCSGLQTPIFKKISKNNYVSPIDIMPAPKVKSTCETRKVSKNRGKTAVLTSSPYLKELQEKKGQKVSKRKVVETKLPKQKKPRKGTKGQNKKNTEPISSDEEVEDTSCIVCDGTFLKSKEGEGWISCSICRLWAHEECSGFDTDNDKPYVCDFCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N3ZYY3</accession>
    <name>A0A5N3ZYY3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nose resistant-to-fluoxetine protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_15382</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01001566">
        <property type="protein sequence ID" value="KAB0790282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N3ZYY3"/>
    <dbReference type="InParanoid" id="A0A5N3ZYY3"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006621">
        <property type="entry name" value="Nose-resist-to-fluoxetine_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052728">
        <property type="entry name" value="O2_lipid_transport_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161">
        <property type="entry name" value="O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161:SF0">
        <property type="entry name" value="O-ACYLTRANSFERASE LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20146">
        <property type="entry name" value="NRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00703">
        <property type="entry name" value="NRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024394202" description="Nose resistant-to-fluoxetine protein N-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="290"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="407"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="434"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="473"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="509"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="547"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="579"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="621"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="domain" description="Nose resistant-to-fluoxetine protein N-terminal" evidence="3">
        <location>
            <begin position="50"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0790282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="659" mass="74057" checksum="856878DA12AF8BB5" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N3ZZ93</accession>
    <name>A0A5N3ZZ93_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4218 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_15239</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01001381">
        <property type="protein sequence ID" value="KAB0790391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N3ZZ93"/>
    <dbReference type="InParanoid" id="A0A5N3ZZ93"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33053">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33053:SF24">
        <property type="entry name" value="TRANSPOSASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0790391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="164" mass="18971" checksum="CB4AFF4E9905738D" modified="2020-02-26" version="1" fragment="single">MVALKHYIPQEINRKPRPLSELARFKATEFRSFLLYIGPIVLPQVVDIAIYEHFLLLHAAIVILCSRKHIVQFGCDSAFQLLKTFVQHSEHLYGAEFQIFNVHNLIHLPADVAMYGPLDCFSAFPLENFLGQLKRLIKSPKEPLKQICKRLQEISFLIDEKQQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N3ZZW4</accession>
    <name>A0A5N3ZZW4_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_14992</name>
        <name evidence="8" type="ORF">PPYR_15184</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01001037">
        <property type="protein sequence ID" value="KAB0790602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000740">
        <property type="protein sequence ID" value="KAB0790816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N3ZZW4"/>
    <dbReference type="FunCoup" id="A0A5N3ZZW4">
        <property type="interactions" value="17"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N3ZZW4"/>
    <dbReference type="OrthoDB" id="6258998at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061024">
        <property type="term" value="P:membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038599">
        <property type="entry name" value="LAP1C-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008662">
        <property type="entry name" value="TOIP1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18843:SF7">
        <property type="entry name" value="LAMINA-ASSOCIATED POLYPEPTIDE 1B ISOFORM 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18843">
        <property type="entry name" value="TORSIN-1A-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="16"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0790602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0790816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="319" mass="35714" checksum="B5A45A551B3D2DBD" modified="2020-02-26" version="1">MSSQRYRKNIRKGIPATSTPYGRLSPNKSNKSISPILIHKQQASDLESDSSSSSSDSLSAPRIDRNFECESLPRKNININKSQSNLKVDTKYMPTVALCFVIVVGVFTITYAAMSSNNKECTFISIEEIQEKFPSQPQSTFNAIVSGVSEIKAFNKPSIFLFLYDSDTRQTINDLTLAIADYASGILNDDCTSNPIILTSSALSTKTDYGTIISTYKPDLEERKVMIVKNLNQIPGTNAQAFHSICDEYSPLVPKSLIMFTVEVKKSNKKYKSDYEHVEEILKESWSDLDDDIFYPLFTRITSMVLKVQPTNTENVIAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A070</accession>
    <name>A0A5N4A070_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_02766</name>
        <name evidence="4" type="ORF">PPYR_14853</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000887">
        <property type="protein sequence ID" value="KAB0790696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0790966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A070"/>
    <dbReference type="FunCoup" id="A0A5N4A070">
        <property type="interactions" value="1248"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A070"/>
    <dbReference type="OrthoDB" id="756370at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120330">
        <property type="term" value="C:rixosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045227">
        <property type="entry name" value="WDR18/Ipi3/RID3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18763:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18763">
        <property type="entry name" value="WD-REPEAT PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="271"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0790696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0790966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="404" mass="45142" checksum="325F2C858C5B8BE7" modified="2020-02-26" version="1">MSHAEEVLITSCKTSLQVWSSQGSGSMNSIHTYKNNGEIVPNSLNLINNRLVTTAHHGKPLLHIWPINSPDEIKNPRFVLPGPANVYKVTPDGHYLVAGINRTLYIWQISSGTLLTAQEIHLCPITCIAISLNSTHVLVGAANGCVLVYNFVHLISVEDVHYAQKELGKVKPLHNLLHHTNAVTDIQVELVNVNPRFVTSSLDNSCFIYDLRTGQPRLHIVCDEPITSTTVDAVFWNVYFGHAAGDIVQFSVSGSTSGLVHFTAPAAHLRFAGHSGRINCVDLNRTNELLVSGSDDSCVIVWNIESKQILNRLELKTPITNVKFLLNTNTFDPHYQPRYIVKELQRTLEGNAYKSFECEVYQDSSFVCESDDARWEEIDSLRKRLHLVSRVNHCLVKRLKSGTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A0A8</accession>
    <name>A0A5N4A0A8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_15656</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000810">
        <property type="protein sequence ID" value="KAB0790751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A0A8"/>
    <dbReference type="FunCoup" id="A0A5N4A0A8">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A0A8"/>
    <dbReference type="OrthoDB" id="441660at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024457128" description="C-type lectin domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="159"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0790751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="289" mass="33972" checksum="4742486863A23FC2" modified="2020-02-26" version="1">MHLQIMNIFTFAFFAAALVWAQSSKNGNREHAEPEVDWEVARQNRITQQILQYYLERKLFPQLKRPPLSRVPSPDEILARQKKRFNYDKIELLLNATRRREAETLQSVESERVTSVYDKEENWIENTLDFEGGEEDCPNCIDDSTSPASTRWTMPLLKLGDKRYYLGIFFKANYFRATQFCRFHGMHLASISSQEENDKLEKYIKDFGLGNEHFWTSGTDLADEGKFFWMSNGRPLTFTNWNAGEPNNFVYENGEEENCLELWNRDGKGLKWNDSPCSFETFFVCEIQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A121</accession>
    <name>A0A5N4A121_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Choline kinase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_02825</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the choline/ethanolamine kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A121"/>
    <dbReference type="FunCoup" id="A0A5N4A121">
        <property type="interactions" value="436"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A121"/>
    <dbReference type="OrthoDB" id="3649325at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004103">
        <property type="term" value="F:choline kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004305">
        <property type="term" value="F:ethanolamine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05156">
        <property type="entry name" value="ChoK_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603">
        <property type="entry name" value="CHOLINE/ETHANOALAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603:SF93">
        <property type="entry name" value="RE24176P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01633">
        <property type="entry name" value="Choline_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="1" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="2" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0791025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="373" mass="43459" checksum="22ABB19976C89386" modified="2020-02-26" version="1">MTHWSIRKMSGDNSEMRELAARICRDYLHGAWKHVNAQNIGFKHISGGLSNLLYYISLPDTLPENVKEEADPKEVLIRVYGQTHGERALEALITESVIFTLLSERGLGPKLHGIFPGGRIEQYVNARPLKTKELADEHLSMTISQRMAAIHSMEVPLHKTPGWLWDTMERWLKSSEERFSGDVPAAVKHLKEMSLRREFLWLKQRLQMENSPVVFCHNDMQEGNILMIEDDTVTSNADAKLVLIDFEYCSYNYRAFDIANHFLEWTYDYTEKQQPYFKVTPENYPSNLQRIKYICHYLKETGSAENPLDVLREVEIFSLASHFFWALWSIVNTKSSQITFGYWEYAVERLNAYNELKTRLHKQGIKRKADGPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A2I0</accession>
    <name>A0A5N4A2I0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Adiponectin receptor protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PPYR_03312</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ADIPOR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A2I0"/>
    <dbReference type="InParanoid" id="A0A5N4A2I0"/>
    <dbReference type="OrthoDB" id="5585746at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033211">
        <property type="term" value="P:adiponectin-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855:SF52">
        <property type="entry name" value="ADIPONECTIN RECEPTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="ADIPOR/PROGESTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="131"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR604254-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0791512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="336" mass="38550" checksum="77086F9291813CEB" modified="2020-02-26" version="1">MRNAARLILAETMARRRRKHKVQPVEEENDFLSFAHSAADQAEQVVRKIIQASWNVCHFNMLPHWLQDNDYLKHGHRPPLPSFRDCFKSIFRIHTETGNIWTHLIGCIAFICIGAYFLVHPTLEIQLQEKLLFGIFFVGAIVCLGFSFAFHTVCCHSEFVSLLFSKLDYCGISLLIMCSNVPWLYYGFYCHFHPKVIYLIAVCVLGVATILISFLEKFSVPEWRTFRAGLFICFGLSGIIPAIHYGFLEGWFNSVSLKSLAWLFLMGLLYIAGAVLYALRIPERFFPGKFDIWLHSHQIFHLFVISGALVHFRGITELALHRVSFAQCDLANALIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A2R5</accession>
    <name>A0A5N4A2R5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cilia- and flagella-associated protein 61 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_03407</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A2R5"/>
    <dbReference type="FunCoup" id="A0A5N4A2R5">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A2R5"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038884">
        <property type="entry name" value="CFAP61"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056299">
        <property type="entry name" value="CFAP61_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032151">
        <property type="entry name" value="CFAP61_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21178">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21178:SF8">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23150">
        <property type="entry name" value="CFAP61_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16092">
        <property type="entry name" value="CFAP61_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cilia- and flagella-associated protein 61 N-terminal" evidence="1">
        <location>
            <begin position="26"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="Cilia- and flagella-associated protein 61 N-terminal" evidence="1">
        <location>
            <begin position="410"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="CFAP61 dimerisation" evidence="2">
        <location>
            <begin position="1049"/>
            <end position="1170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0791607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1271" mass="146054" checksum="C6CBA60C12DBB00D" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A333</accession>
    <name>A0A5N4A333_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_03535</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A333"/>
    <dbReference type="InParanoid" id="A0A5N4A333"/>
    <dbReference type="OrthoDB" id="3941538at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050129">
        <property type="entry name" value="Zn_alcohol_dh"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43401">
        <property type="entry name" value="L-THREONINE 3-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43401:SF2">
        <property type="entry name" value="L-THREONINE 3-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="6">
        <location>
            <begin position="26"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="5">
        <location>
            <begin position="178"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0791735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="345" mass="37782" checksum="463869E802020AD6" modified="2020-02-26" version="1">MEAIQFSLGEKKLELVNKPVPQIKEPTQILVKVAYSGICGTDLHIIEGHFPCNPNGFTLGHEFSGVVVDVGAEVFQFAKGDNVAVDPNNGCGICHFCHSGDPHYCKSGGINNTIGIYKDGGWAEYVLVPEKQVHKLTEHITLEHAALTEPISCLSHGWDLISPITMGDKVLVTGAGIIGNLWVALLHLQGHRRVTVSEPNGLRRELLQKLGTGFQCITPDELKQRHEKDADYLFDVVIDCTGSAPAIEHAFSLLNAGGTLCIFGVAPPHAKISISPFEIYKKEIRIVGVNVNPFSFPKSLGFLESLSDRYLKFENLGVKTFQLKEYKQAIEELKKGAIAKAVFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A4E7</accession>
    <name>A0A5N4A4E7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosome biogenesis protein BOP1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PPYR_14127</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="7">Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
            <location evidence="7">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
            <location evidence="7">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the WD repeat BOP1/ERB1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A4E7"/>
    <dbReference type="FunCoup" id="A0A5N4A4E7">
        <property type="interactions" value="1263"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A4E7"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070545">
        <property type="term" value="C:PeBoW complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000061">
        <property type="entry name" value="Ribosome biogenesis protein BOP1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03027">
        <property type="entry name" value="BOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028598">
        <property type="entry name" value="BOP1/Erb1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012953">
        <property type="entry name" value="BOP1_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17605:SF0">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17605">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BOP1 BLOCK OF PROLIFERATION 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08145">
        <property type="entry name" value="BOP1NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01035">
        <property type="entry name" value="BOP1NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2 7" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 8" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BOP1 N-terminal" evidence="10">
        <location>
            <begin position="117"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="388"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="32"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00055102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0792168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="730" mass="83851" checksum="DC70052DB8AED796" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A4M0</accession>
    <name>A0A5N4A4M0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Death domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PPYR_14211</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A4M0"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08317">
        <property type="entry name" value="Death_ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.220.30:FF:000009">
        <property type="entry name" value="Ankyrin 2, isoform G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000095">
        <property type="entry name" value="Ankyrin 2, isoform J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000003">
        <property type="entry name" value="Ankyrin, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000001">
        <property type="entry name" value="Ankyrin-2 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.220.30:FF:000001">
        <property type="entry name" value="Ankyrin-3 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.2660:FF:000001">
        <property type="entry name" value="Ankyrin-3 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.30">
        <property type="match status" value="2"/>
    </dbReference>
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        <source>
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        </source>
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    <sequence length="4050" mass="446991" checksum="4C1EA2726EA5D4FD" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A588</accession>
    <name>A0A5N4A588_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PPYR_14407</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="InParanoid" id="A0A5N4A588"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015149">
        <property type="term" value="F:hexose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="MFS_GLUT_Class1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000029">
        <property type="entry name" value="solute carrier family 2, facilitated glucose transporter member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045263">
        <property type="entry name" value="GLUT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503:SF128">
        <property type="entry name" value="GLUCOSE TRANSPORTER TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="316"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="350"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="380"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="507"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="532"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="559"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="598"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="628"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="209"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="138"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="39"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0792448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="679" mass="75582" checksum="10B9B162CF6C75B0" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A5G5</accession>
    <name>A0A5N4A5G5_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_14524</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A5G5"/>
    <dbReference type="InParanoid" id="A0A5N4A5G5"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0792565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="169" mass="19037" checksum="EF99D96153812302" modified="2020-02-26" version="1">MRRVRLRLEWDFVIAAVLFAEEIKAGLTTQAPSIVANPSTSSRPTSNDDDVTELLQPLVHVINASLENETSSAQNQTDDESESHASFPQSYDDIVEYLKNLGYTGTIVAITLATLLILAIGILTSYVCWKVRVCRETRSRYNRRPKYVSVPGDQYVYDKLMHEPEAEDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A5H8</accession>
    <name>A0A5N4A5H8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein takeout</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_14553</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A5H8"/>
    <dbReference type="FunCoup" id="A0A5N4A5H8">
        <property type="interactions" value="31"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A5H8"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007623">
        <property type="term" value="P:circadian rhythm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.15.10.30:FF:000001">
        <property type="entry name" value="Takeout-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.30">
        <property type="entry name" value="Haemolymph juvenile hormone binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010562">
        <property type="entry name" value="Haemolymph_juvenile_hormone-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038606">
        <property type="entry name" value="To_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008:SF32">
        <property type="entry name" value="CIRCADIAN CLOCK-CONTROLLED PROTEIN DAYWAKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008">
        <property type="entry name" value="PROTEIN TAKEOUT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06585">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00700">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0090">Biological rhythms</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024296928" description="Protein takeout" evidence="4">
        <location>
            <begin position="27"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00060902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0792594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="256" mass="28995" checksum="A08925691675538E" modified="2020-02-26" version="1">MKMWITRQVSIMKTYVFYFLVSAAVGLQLPPDFPKCRRGDPKINECLKPAIEGALKIMEKGMPEFKLESIQPITVPSLTIGEGKGAVQVVQQYENCKIFNIPSGKIIDVDSLITENEFRLNTTIHLKEVYLSSQYKLNGRILLLPIVGDGDCTIKLKNAKVPVELIGSPIEKKGLKYMEITDLNVHLNAEKVEFDFKNLFNGDPRLGPEMNKILNENWKEIFDDVKYAYDEALGAIFKTIANLIFKRVPFADLLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A601</accession>
    <name>A0A5N4A601_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">asparaginase</fullName>
            <ecNumber evidence="1">3.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PPYR_14723</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the asparaginase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.1" evidence="1"/>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A601"/>
    <dbReference type="FunCoup" id="A0A5N4A601">
        <property type="interactions" value="76"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A601"/>
    <dbReference type="OrthoDB" id="542841at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004067">
        <property type="term" value="F:asparaginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006528">
        <property type="term" value="P:asparagine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd08963">
        <property type="entry name" value="L-asparaginase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1170:FF:000003">
        <property type="entry name" value="60 kDa lysophospholipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.40:FF:000001">
        <property type="entry name" value="L-asparaginase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1170">
        <property type="entry name" value="L-asparaginase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006033">
        <property type="entry name" value="AsnA_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036152">
        <property type="entry name" value="Asp/glu_Ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006034">
        <property type="entry name" value="Asparaginase/glutaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020827">
        <property type="entry name" value="Asparaginase/glutaminase_AS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027475">
        <property type="entry name" value="Asparaginase/glutaminase_AS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040919">
        <property type="entry name" value="Asparaginase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027473">
        <property type="entry name" value="L-asparaginase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041725">
        <property type="entry name" value="L-asparaginase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027474">
        <property type="entry name" value="L-asparaginase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037152">
        <property type="entry name" value="L-asparaginase_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00519">
        <property type="entry name" value="asnASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11707:SF28">
        <property type="entry name" value="60 KDA LYSOPHOSPHOLIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11707">
        <property type="entry name" value="L-ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00710">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17763">
        <property type="entry name" value="Asparaginase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001220">
        <property type="entry name" value="L-ASNase_gatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500176">
        <property type="entry name" value="L_ASNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00139">
        <property type="entry name" value="ASNGLNASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00057">
        <property type="entry name" value="Glutaminase/Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00870">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53774">
        <property type="entry name" value="Glutaminase/Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00144">
        <property type="entry name" value="ASN_GLN_ASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00917">
        <property type="entry name" value="ASN_GLN_ASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51732">
        <property type="entry name" value="ASN_GLN_ASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="L-asparaginase N-terminal" evidence="10">
        <location>
            <begin position="10"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Asparaginase/glutaminase C-terminal" evidence="11">
        <location>
            <begin position="241"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="19"/>
        </location>
    </feature>
    <feature type="active site" description="O-isoaspartyl threonine intermediate" evidence="6">
        <location>
            <position position="19"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="120"/>
            <end position="121"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00061199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001220-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001220-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAB0792764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="369" mass="40926" checksum="E2DCD1EB2686CC7E" modified="2020-02-26" version="1">MPGECKEIKKVLVVYTGGTIGMQKNHKGVYVPSPHPLTRQLRNIPELHNKEYAELYFGEQRSDELIIPYIYEEQVVVYTVIEYDPLYDSSNMSVKDWIRIATDIETYYYKYDGFVILHGTDTLAYTASALSFMLNGLQKPVVLTGSQIPIYENRSDAKSNFLASLIIAACFNVSEVCVYFSNKLFRGNRTAKVSTNLLDAFDSPNIPPLANIGIDITMNRSLTLKSNREEEFVVSKNLNPNVVVLSVFPTITGAMIKSFIGKGVDGVVLQSYGAGNVPTNRKDVLDVFREAIESGVIIVNITQCAQGAVAPTYETGQALKEIGLICGYDMTVEAALTKLSYVLGQDQLLLEEKKKLISINLRGELTDGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A6Y1</accession>
    <name>A0A5N4A6Y1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">palmitoyl-CoA hydrolase</fullName>
            <ecNumber evidence="7">3.1.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PPYR_08236</name>
        <name evidence="11" type="ORF">PPYR_12649</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the cleavage of thioester bonds from S-palmitoyl-CoA or S-palmitoyl-N-acetylcysteamine (unbranched structures) but does not have activity against palmitoylcysteine or palmitoylated proteins, branched structures or bulky head groups. Conversely, hydrolyzes both long and short chain fatty acyl-CoA substrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>S-hexadecanoyl-N-acetylcysteamine + H2O = N-acetylcysteamine + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:84099"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:74410"/>
            <dbReference type="ChEBI" id="CHEBI:233601"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the palmitoyl-protein thioesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.2" evidence="7"/>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A6Y1"/>
    <dbReference type="FunCoup" id="A0A5N4A6Y1">
        <property type="interactions" value="843"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A6Y1"/>
    <dbReference type="OrthoDB" id="155976at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098599">
        <property type="term" value="F:palmitoyl hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016790">
        <property type="term" value="F:thiolester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000037">
        <property type="entry name" value="Lysosomal thioesterase PPT2 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11247:SF27">
        <property type="entry name" value="LYSOSOMAL THIOESTERASE PPT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11247">
        <property type="entry name" value="PALMITOYL-PROTEIN THIOESTERASE/DOLICHYLDIPHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02089">
        <property type="entry name" value="Palm_thioest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0458">Lysosome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036371572" description="palmitoyl-CoA hydrolase" evidence="10">
        <location>
            <begin position="19"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00093223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00093353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0793029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAB0797242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="284" mass="32345" checksum="A1324BAC29349510" modified="2020-02-26" version="1">MGLRVLVLIFSLSLLVAGYKPTVLLHGILTGSECMTLIKDRIQEKHPGTVVYNIDRFGGWSSLDSMWYQIQQLKMDILNISQSHPEGFNFLGYSQGGLLGRALIQDLPDHNVHNFISLSSPQAGQYGTEFLHIIFPNLALKTAYELFYSRVGQHTSVGNYWNDPHHQSLYYSYSDFLPYINNEIGSNKSEQFKAAILKLNKLVLIGGPDDNVITPWQSSQFGYFNLNETVVKLVDRDIYIEDTIGLRTLDKKGKLILITVPGIDHYMWHINETIVDQYILPYLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A748</accession>
    <name>A0A5N4A748_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mediator of RNA polymerase II transcription subunit 23</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Mediator complex subunit 23</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PPYR_12761</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A5N4A748">
        <property type="interactions" value="1315"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A748"/>
    <dbReference type="OrthoDB" id="9982951at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021629">
        <property type="entry name" value="Mediator_Med23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12691">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12691:SF10">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11573">
        <property type="entry name" value="Med23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0793141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1310" mass="149268" checksum="8B84FB226FD72243" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A9H4</accession>
    <name>A0A5N4A9H4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_13591</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A9H4"/>
    <dbReference type="InParanoid" id="A0A5N4A9H4"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0793971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="218" mass="25308" checksum="0E37BD15D4CAAFCD" modified="2020-02-26" version="1">MSRARSSRNQKKLRRGIALISHGLLHEVNAMLSTRKRAQRRWWVKPWVSRRTKLGASSTLLREWAKENPEVYRNHLRMTEEQFAYLLDKVTPFISKKDTWFREALSPKIKLQMTLRYLATGDNIGTLSALYRIPRSTFSRFLPEVCKAIYNALADFIMVPNTVESWENVMRDYETLWNFPNVCGAMDGKHVNGRVNDAAVFAKSTFNEALQNNSLNIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A9H7</accession>
    <name>A0A5N4A9H7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PPYR_13600</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A9H7"/>
    <dbReference type="InParanoid" id="A0A5N4A9H7"/>
    <dbReference type="OrthoDB" id="687730at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013642">
        <property type="entry name" value="CLCA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08434">
        <property type="entry name" value="CLCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024288384" description="VWFA domain-containing protein" evidence="4">
        <location>
            <begin position="17"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="917"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="5">
        <location>
            <begin position="292"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1177"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1011"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1177"/>
            <end position="1193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0793980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1204" mass="134382" checksum="81B3B78F8CF46529" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A9T4</accession>
    <name>A0A5N4A9T4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">E3 ubiquitin-protein ligase RBBP6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PPYR_13669</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0794049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A5N4A9T4">
        <property type="interactions" value="626"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A9T4"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16620">
        <property type="entry name" value="vRING-HC-C4C4_RBBP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000070">
        <property type="entry name" value="E3 ubiquitin-protein ligase RBBP6 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014891">
        <property type="entry name" value="DWNN_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033489">
        <property type="entry name" value="RBBP6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15439:SF0">
        <property type="entry name" value="CELL DIVISION CYCLE AND APOPTOSIS REGULATOR PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15439">
        <property type="entry name" value="RETINOBLASTOMA-BINDING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <source>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1606" mass="185591" checksum="F0A1D1F338CACC63" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AA31</accession>
    <name>A0A5N4AA31_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Protein transport protein Sec31A</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">SEC31-like protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">SEC31-related protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PPYR_13802</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">1611_PpyrPB1</strain>
            <tissue evidence="20">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat SEC31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0794182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AA31"/>
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        <property type="interactions" value="1746"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AA31"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007029">
        <property type="term" value="P:endoplasmic reticulum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.940.10:FF:000001">
        <property type="entry name" value="Protein transport protein Sec31A isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000009">
        <property type="entry name" value="Protein transport protein Sec31A isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.1030:FF:000011">
        <property type="entry name" value="SEC31 homolog B, COPII coat complex component"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Functional domain of the splicing factor Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Sec16_Sec23-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040251">
        <property type="entry name" value="SEC31-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13923">
        <property type="entry name" value="SEC31-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13923:SF11">
        <property type="entry name" value="SECRETORY 31, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TPR_Sec16"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="6 17" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="17">
        <location>
            <begin position="114"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="17">
        <location>
            <begin position="251"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Sec16 Sec23-binding" evidence="19">
        <location>
            <begin position="548"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="793"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="863"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="793"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="18">
        <location>
            <begin position="813"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="904"/>
            <end position="918"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004180"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00009358"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00043112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF12931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAB0794182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1170" mass="128524" checksum="DD7BB2ED9DF56A82" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AAB0</accession>
    <name>A0A5N4AAB0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PPYR_13864</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">1611_PpyrPB1</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0794244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AAB0"/>
    <dbReference type="InParanoid" id="A0A5N4AAB0"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11056">
        <property type="entry name" value="CYP6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000182">
        <property type="entry name" value="Cytochrome P450 3A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050476">
        <property type="entry name" value="Insect_CytP450_Detox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292:SF54">
        <property type="entry name" value="CYP9F3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0492">Microsome</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAB0794244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="327" mass="38044" checksum="DF7089371A216B3C" modified="2020-02-26" version="1">MGKETTNFGGFWKNMKFLIMMFSPRLATFFGLHLFSNKVSTFFRNLVTGNMAERERNGIVRPDMIHLLMEARKGRLKHERSNEIIDSGFAAIEESEIGKDENRQKLELSDDDVTAQSMIFFFAGFETVSTLMCFTAYELAVNPYIQERLREEVDNVLKDGNGILTHEGLMKMEYMDMVISEVLRKWPPAVGTDRMCVKPYTIHPEREGEKPVHLKKGDVVFMIMYGIQRDEKYFPDPDRFDPERFSKENRKNITPYSYMPFGAGPRSCIANRFALLETKLLIFNVLRYFEIVVVKKSVVPIKLSRKQLNLNAEGGFWFGLKPRKVYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AAR2</accession>
    <name>A0A5N4AAR2_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tetraspanin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PPYR_11208</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the tetraspanin (TM4SF) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0794369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AAR2"/>
    <dbReference type="InParanoid" id="A0A5N4AAR2"/>
    <dbReference type="OrthoDB" id="9993879at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03127">
        <property type="entry name" value="tetraspanin_LEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1450.10">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000301">
        <property type="entry name" value="Tetraspanin_animals"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282:SF544">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002419">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00259">
        <property type="entry name" value="TMFOUR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="155"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR002419-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0794369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="230" mass="24781" checksum="D64BA4F37ACAEE9A" modified="2020-02-26" version="1">MCIILDALASPIRVIFCVNTKLYIFSGVMIVIMVPVLSNTKVGTYILALRNYFDVVKVGPPALIGFGVALIVIGLLGHYGASSGSTRCLASYMFLCVGLIVLEIIVATYVLMKLPKNSGAILKDIQNKFKELIQSYYTDPEIKLAIDFVQSEFECCGSIDRFDWGGIGSTPDSCTCRGCLVSYGFGCSEYIFDLVSGKLAMVPTIAYAVLGFQVAGLVVAYFLLIILGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ABQ1</accession>
    <name>A0A5N4ABQ1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Elongation of very long chain fatty acids protein</fullName>
            <ecNumber evidence="10">2.3.1.199</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Very-long-chain 3-oxoacyl-CoA synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PPYR_11583</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:32727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="ChEBI" id="CHEBI:90736"/>
            <dbReference type="EC" id="2.3.1.199"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ELO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.199" evidence="10"/>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0794744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ABQ1"/>
    <dbReference type="FunCoup" id="A0A5N4ABQ1">
        <property type="interactions" value="355"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4ABQ1"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF162">
        <property type="entry name" value="ELONGATION OF VERY LONG CHAIN FATTY ACIDS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0794744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="302" mass="35464" checksum="46A6D0198112A51F" modified="2020-02-26" version="1">MSSPVPTLAICLFYVYFSKVMGPKLMENRKPFDLRQILIIYNFIQTIFSAWIFYEYLMSGWWGSYSFRCQPVDYSSNPMALRMANVCWWYYFSKFTEFLDTLFFILRKKFSHVSTLHVIHHGCMPFSVWMGVKFAAGGHSTFFALLNTFVHVVMYFYYMLSAMGPQYQKYIWWKKYLTTFQMVQFVLIFTHQFQLLFTDCDYPKGFMVWIGFHGVMFLFLFSDFYKVKYTSGKKAVQNNNTGACMVVEDEVHTNGKVSNGTMGETLTSSYLESELSSTYKPCYSNGINNGFVSYQRNGKKID</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AEI5</accession>
    <name>A0A5N4AEI5_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_09801</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0795740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AEI5"/>
    <dbReference type="InParanoid" id="A0A5N4AEI5"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23992">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.20">
        <property type="entry name" value="Pheromone/general odorant binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006170">
        <property type="entry name" value="PBP/GOBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036728">
        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01395">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0795740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="121" mass="13580" checksum="CF25C640AF8D71B5" modified="2020-02-26" version="1" fragment="single">QVPEEFRMDWVSTAEPFRTGCECESGVAPHLSQRVLSLADFTNDPCLKSYIFCLFTKLNLINPATYEISVKEHVRHVAGVDEMIATNCVNATRGLKDSREKVYQMSLCVVFSLVQPPISIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AF18</accession>
    <name>A0A5N4AF18_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_09960</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0795899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AF18"/>
    <dbReference type="InParanoid" id="A0A5N4AF18"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031681">
        <property type="term" value="F:G-protein beta-subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052236">
        <property type="entry name" value="Small_GTPase_RasD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46149">
        <property type="entry name" value="MIP08469P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46149:SF3">
        <property type="entry name" value="MIP08469P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0795899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="64" mass="7217" checksum="BB3B48D0434F2929" modified="2020-02-26" version="1" fragment="single">DLFVIVFSMDSRETFEEALRLREQILETKFSAGGASNSGGLTRKRNLPRVPMVLAGNKCDKEMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AGG1</accession>
    <name>A0A5N4AGG1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_10468</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AGG1"/>
    <dbReference type="FunCoup" id="A0A5N4AGG1">
        <property type="interactions" value="40"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AGG1"/>
    <dbReference type="OrthoDB" id="6156898at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019903">
        <property type="term" value="F:protein phosphatase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035591">
        <property type="term" value="F:signaling adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007409">
        <property type="term" value="P:axonogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007185">
        <property type="term" value="P:cell surface receptor protein tyrosine phosphatase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09497">
        <property type="entry name" value="SAM_caskin1_2_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000071">
        <property type="entry name" value="Caskin, isoform D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000028">
        <property type="entry name" value="caskin-2 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035497">
        <property type="entry name" value="Caskin1/2_SAM_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24155:SF11">
        <property type="entry name" value="CASKIN, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24155">
        <property type="entry name" value="OSTEOCLAST-STIMULATING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAM" evidence="3">
        <location>
            <begin position="320"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="3">
        <location>
            <begin position="389"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="55"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="132"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="242"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="578"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="652"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="754"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="824"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="155"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="189"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="203"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="247"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="291"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="670"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="696"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="713"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="756"/>
            <end position="770"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0796407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="851" mass="93369" checksum="2BA72056626E828B" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AGL6</accession>
    <name>A0A5N4AGL6_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_10528</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AGL6"/>
    <dbReference type="InParanoid" id="A0A5N4AGL6"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="265"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0796467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="319" mass="37247" checksum="C593CA0501C06DFB" modified="2020-02-26" version="1">MAKPSKEKSISHAIKPLHIVMQLTGHFSLEKSTGFLKVWNIQMKILCFFCCAVHIYACPMEIDNVNSIAMAIFQCYNYFCVFHTLIFNSIYNKRIRVILTEIIKVNRLSEFITKEKVNYLLSRRRMIIYISFWYGFQIICGMLSHFSVYNYERREQSKFYCMYIGLPTNCFNFNMNCLLQFILGEIKERSAKVHNHAVLFQESEIYALVKNVPTFYHQLLNCAQSIKCAFEFVLLSKIVMCTIHLLITVYWFTTGKFKEHLGGNFILFGLGSFIVLNVIDVVVVLYSFVSFIDEVNIPTLEQNAPVTIFDISLKTNRFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AGN7</accession>
    <name>A0A5N4AGN7_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_10591</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AGN7"/>
    <dbReference type="InParanoid" id="A0A5N4AGN7"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0796530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1119" mass="128955" checksum="ED821F823B4A278B" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AI08</accession>
    <name>A0A5N4AI08_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">LITAF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PPYR_11018</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Late endosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Lysosome membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CDIP1/LITAF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AI08"/>
    <dbReference type="InParanoid" id="A0A5N4AI08"/>
    <dbReference type="OrthoDB" id="5599753at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006629">
        <property type="entry name" value="LITAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037519">
        <property type="entry name" value="LITAF_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23292:SF6">
        <property type="entry name" value="FI16602P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23292">
        <property type="entry name" value="LIPOPOLYSACCHARIDE-INDUCED TUMOR NECROSIS FACTOR-ALPHA FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10601">
        <property type="entry name" value="zf-LITAF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00714">
        <property type="entry name" value="LITAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51837">
        <property type="entry name" value="LITAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="LITAF" evidence="10">
        <location>
            <begin position="84"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="16"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="33"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="51"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0796957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="172" mass="18996" checksum="58749A9AB6B8C18D" modified="2020-02-26" version="1">MFTLWIPNISRIKKMEKIPPPPPYEESTHSPPLNNYSQAYPPQSRNAGYPTLPPPQMGFPPPPQVGFQQPGFIPQPTPSVPQAQYSRYPQPQVVTVFGPIPQLINCPHCHNQVTSKLEASAGTKTHLFAALLCILGCIPCCLIPYCVDSCKDRSHYCPQCNAFLGSYGTALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AJ33</accession>
    <name>A0A5N4AJ33_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PPYR_08290</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">1611_PpyrPB1</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Endomembrane system</location>
            <topology evidence="11">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AJ33"/>
    <dbReference type="FunCoup" id="A0A5N4AJ33">
        <property type="interactions" value="1331"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AJ33"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02123">
        <property type="entry name" value="PA_C_RZF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16796">
        <property type="entry name" value="RING-H2_RNF13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000429">
        <property type="entry name" value="E3 ubiquitin-protein ligase RNF13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.30:FF:000026">
        <property type="entry name" value="E3 ubiquitin-protein ligase RNF13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051653">
        <property type="entry name" value="E3_ligase_sorting_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044744">
        <property type="entry name" value="ZNRF4/RNF13/RNF167_PA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47168:SF1">
        <property type="entry name" value="OS02G0798600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47168">
        <property type="entry name" value="RING ZINC FINGER DOMAIN SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="171"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="15">
        <location>
            <begin position="228"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="279"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="295"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="355"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00046288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAB0797296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="383" mass="42475" checksum="C733A456687482F0" modified="2020-02-26" version="1">MEHLLFYSVSIFICILKYVTSDVLVLPIDGRYIAEEFRDKASLFGNPLPYKGLQGILVYANPPDACNSLLSPPDLPGYKGMFVVLIARSPQNCSFEHKVRMAENASYDGVIVHNVGSDELEPMSAKNKVGITIPSVFVSETTGRILQEMYCSPDYFVIINSEMPFNFNSTLLIPFAIVVGVCFIVMVIFIVIKFIKDRRRQRRHRLPSSTLNQIPTCKFAKGDPYDTCAICLDDYVEGEKLRVLPCAHAYHCKCIDPWLTKNRRVCPVCKRKVFAQHESHHSNSDSDSDADDTTPLMNSSNQMSHSGGTFDSLSENPFQRAARSASQHADGVNLVTASGHHSINGEVEASDDSDSSTSSDSSHHSTAALITLLRDVEEQLQGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AJB9</accession>
    <name>A0A5N4AJB9_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_08439</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AJB9"/>
    <dbReference type="InParanoid" id="A0A5N4AJB9"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0797445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="251" mass="29092" checksum="9DDBE7475B42D45B" modified="2020-02-26" version="1">MGHNKVQIVTEKANEPEKVDGENGKPKPAGSSTYEPVFRWWQKPSIKYAFSHPYVRSRLEKLMGSNVVNLTDREYMQLLQERILENYANEMNKRIATREAEEMERVKNLVLIGRIPLDEAPPEMVDHPVRLIEMHCRRLIAERRAKIKVHKGFIPKHLYVDDTPDPPSGLSIEEGHVFRSKNERLCHPPACVLSIPDKEDVKRGYMFTEENYAKLNLEGSLIQELRKSQTVEEMYQLADRIMGITTPEAEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AJR5</accession>
    <name>A0A5N4AJR5_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_08573</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AJR5"/>
    <dbReference type="FunCoup" id="A0A5N4AJR5">
        <property type="interactions" value="15"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AJR5"/>
    <dbReference type="OrthoDB" id="8184571at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007608">
        <property type="term" value="P:sensory perception of smell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23992">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.20">
        <property type="entry name" value="Pheromone/general odorant binding protein domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006170">
        <property type="entry name" value="PBP/GOBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036728">
        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11857">
        <property type="entry name" value="ODORANT BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01395">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024306029" evidence="2">
        <location>
            <begin position="20"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0797580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="199" mass="22867" checksum="D909D44936CA2B07" modified="2020-02-26" version="1">MKFLIIMLLLVFAQQRCSSKIISDWEIGLEKYSMKCANETNLDPTISKRILREFYMPDERNFQCFLKCIMENSGVLKSSHEVDIQELIELPQHLIDDWNAVQNPHREKCVNLTKIDPSLPERLLTEMHVPDDDGFKCYLKCVLENVKVIVGNDIDVDTLSAVVHMTRDLSEKCANATRSESDACRKSFILTGCVLQNQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AKH4</accession>
    <name>A0A5N4AKH4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_08711</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AKH4"/>
    <dbReference type="InParanoid" id="A0A5N4AKH4"/>
    <dbReference type="OrthoDB" id="550424at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000002">
        <property type="entry name" value="Dnaj homolog subfamily b member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000006">
        <property type="entry name" value="DnaJ subfamily B member 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000106">
        <property type="entry name" value="Putative heat shock protein-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051339">
        <property type="entry name" value="DnaJ_subfamily_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24078:SF519">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24078">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="4"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0797718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="345" mass="39458" checksum="579276A1FFD03FD9" modified="2020-02-26" version="1">MGIDYYGVLSIQRNSNELEIRKAYRNLALEFNPERLQDDGTHKIFALIGEAYEVLSNPLLRAVFDQYGEEGLKRGVPGPGEYIPSYHYHGDPLRTYKEFFGTASPYADLLNYLKDPPSLYELPEVRGVRKKQPPIYHPLCLTLHEIYFGGVKKMKIRRLQFIGSDCILTELKENILSVPIKPGIKPETLIIFPEEGDQNPLHIPADVIFVTKEREHECFTRQNNDLIMRVEISLEEALLGTTVTVSTIDHRTLRVPITDVVSPSYEKVVENEGMPILENPENKGNLIIRFTISFPQYIPQSSKDVFQKAFHLVKIGGGFHHEMINKMILADKIMRIDPCEQLPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-06-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ALI2</accession>
    <name>A0A5N4ALI2_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_09195</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ALI2"/>
    <dbReference type="InParanoid" id="A0A5N4ALI2"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0798202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="266" mass="30389" checksum="5EFCF68A6A7F5CE9" modified="2020-02-26" version="1">MNSVDNLHLDSTPLSVRSLMHCKFDYPKRGNIEDGLCCPDDQKMFLTASMSFLQNHLARILNTDISSPVKEARPKRTYSDLLILESSPKCKRTKSYLRLKNIEKYDEISRNEASFFSPILTINQILPSAKKCAERRGIFGIFRRSFSTSGTKGLDEKMRRAYDLLANQGSEETDSCLVSNRSNFKVAPDSRLLLVSSFIKPKGHGDDYDQKSMSKNMEMINTLTRTGAKTNIRQRAKSSNKEQRYNFLDANFTDELKFQYSSDLVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AMQ5</accession>
    <name>A0A5N4AMQ5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Bursicon</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Bursicon subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PPYR_09587</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Heterodimer of burs and pburs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AMQ5"/>
    <dbReference type="FunCoup" id="A0A5N4AMQ5">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AMQ5"/>
    <dbReference type="OrthoDB" id="6493004at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036122">
        <property type="term" value="F:BMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005179">
        <property type="term" value="F:hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038098">
        <property type="term" value="P:sequestering of BMP from receptor via BMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006207">
        <property type="entry name" value="Cys_knot_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004133">
        <property type="entry name" value="DAN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15283:SF7">
        <property type="entry name" value="BURSICON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15283">
        <property type="entry name" value="GREMLIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03045">
        <property type="entry name" value="DAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01225">
        <property type="entry name" value="CTCK_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0372">Hormone</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024388286" description="Bursicon" evidence="10">
        <location>
            <begin position="28"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="CTCK" evidence="11">
        <location>
            <begin position="44"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="58"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAB0798594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="165" mass="18027" checksum="33E1CBF6366FD3FA" modified="2020-02-26" version="1">MFGKFVQILQTWLILVAVTLIANMCMSSSKVKTRVAAANAADECQVTPVIHVLQYPGCVPKPIPSFACTGRCASYIQVSGSKIWQMERSCMCCQESGEREASVSLFCPKAKPGERKFRKVTTKAPLECMCRPCTGVEESAVIPQEIAGYADEGPLSNHFLKSQSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ANK3</accession>
    <name>A0A5N4ANK3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_06743</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0798863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ANK3"/>
    <dbReference type="FunCoup" id="A0A5N4ANK3">
        <property type="interactions" value="14"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4ANK3"/>
    <dbReference type="OrthoDB" id="67700at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070382">
        <property type="term" value="C:exocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048791">
        <property type="term" value="P:calcium ion-regulated exocytosis of neurotransmitter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048488">
        <property type="term" value="P:synaptic vesicle endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000080">
        <property type="entry name" value="Putative synaptotagmin-12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000294">
        <property type="entry name" value="Synaptotagmin 1-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024">
        <property type="entry name" value="SYNAPTOTAGMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024:SF252">
        <property type="entry name" value="SYNAPTOTAGMIN-12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="3">
        <location>
            <begin position="241"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="3">
        <location>
            <begin position="371"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="116"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0798863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="511" mass="57188" checksum="9B5B3F710396C6AC" modified="2020-02-26" version="1">MERVEVAFTVICISAFILLLLVALYHWSTFWTWLATWILSTREEKVGLTRSKVYNANGYLVNSDSDIHLDAIGTFKRFDSVDRDFKITLTTTSLGGQWNKVEEDETIPPQPLRPAPTSVPTSPKTTKTPPLIIEENVPAIRNEESEPVLTIAIPRPKSSISVAELAAKSQFPVCITPPPSPAHPLSVSKYSIGYHQPHSSPNNVQSDEQEVITATLKRAISCDSVCSDSSVALGDLEEPNVTGYLCLGLEYDSELSDLIVNVLEAKDLIGSSQDDNPIDSYVKIYLLPDKATSAQTKLYRYSNSPSYKERFSFPLRPREQSQKSLCFHVYSLDNTSHTLLGEGEIRLTDISLRQPVTTWVTLTDTGQKGTEFGEVMFSLSYLPTAERLTVVVVKARNLKFQNDRDAGDPFVKVYLLHHGKKVHKKKTSTKRGERSPIFNESMIFSVPAHTLQTIQLRLTVAENINNEHPTRTYSIGHVIIGAQASGRSLNHWNQMLTALRKPVAMWHPLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ANK9</accession>
    <name>A0A5N4ANK9_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_06797</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0798917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ANK9"/>
    <dbReference type="InParanoid" id="A0A5N4ANK9"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0798917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="278" mass="30871" checksum="3F1658D8C540588E" modified="2020-02-26" version="1">MKVPWMKCLENQGTLPRQTTSGGEIPKKEKSTRWRHAWNSLRKFRLRKRRKGTTKEDDPQNGVVSQRSTLSSSCSSSPSVASLHGDIKGVWSPGQKSAEEKPKEVAERQQGEDEPIPSVWQPRSAGASPTAERKEFKPVSFDSPTLRRKNQPAEKESNASEEPPPTQRQWTTPSSASEVGTSLSSILERRLPTSHSAPSTGFSELTSSRLPRAQNPTITLLQKARAYHTKDDSNPERQKKMADLNPARYERGIGPVAKDGMPLVLRSVCQNYSTLTGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4API0</accession>
    <name>A0A5N4API0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_06998</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4API0"/>
    <dbReference type="InParanoid" id="A0A5N4API0"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37162:SF1">
        <property type="entry name" value="BED-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37162">
        <property type="entry name" value="HAT FAMILY DIMERISATION DOMAINCONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="1">
        <location>
            <begin position="497"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0799118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="599" mass="68751" checksum="9BE7BD00A0413A2A" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ARD0</accession>
    <name>A0A5N4ARD0_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_07764</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ARD0"/>
    <dbReference type="InParanoid" id="A0A5N4ARD0"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0799884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="259" mass="29288" checksum="9B3CA96E013A2FBD" modified="2020-02-26" version="1">MEEQHEIITCTPPELREIANSTVDNLLPQKSKLKYEKEYLKFDQWCKENKAQHISENVLLAYFELQTHLKKPSSLWSMYSMLRSYLNVHKNVDISRYVKLQALLKRFSQGYEPKKSKILDLEQINRFIQEADDKHYLDTKPTAVVTWSPLNDMAGGSPPQLPKDKYIETSVQRKVEVAGTLAQASKSSSSLHGILAQGCTSTHVESAVPSAIVEGNINSAEHNIVTHNLPGIKVNTHDGAVTVKVYNNCTFNYADKDEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ASW1</accession>
    <name>A0A5N4ASW1_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_06139</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000004">
        <property type="protein sequence ID" value="KAB0800399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ASW1"/>
    <dbReference type="InParanoid" id="A0A5N4ASW1"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0800399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="57" mass="6476" checksum="E075B7C0E9CF0743" modified="2020-02-26" version="1" fragment="single">KGLVTSEPLKNSDTSGRKFDKRSGTRTIEKLRQMDRNSVIGLVPEPLKNSDTSRRKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ATC9</accession>
    <name>A0A5N4ATC9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PPYR_06306</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Antp homeobox family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000004">
        <property type="protein sequence ID" value="KAB0800566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ATC9"/>
    <dbReference type="FunCoup" id="A0A5N4ATC9">
        <property type="interactions" value="15"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4ATC9"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009952">
        <property type="term" value="P:anterior/posterior pattern specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000017">
        <property type="entry name" value="Homeobox protein antennapedia"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050296">
        <property type="entry name" value="Antp_homeobox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017995">
        <property type="entry name" value="Homeobox_antennapedia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001827">
        <property type="entry name" value="Homeobox_Antennapedia_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45659:SF4">
        <property type="entry name" value="HOMEOBOX PROTEIN ABDOMINAL-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45659">
        <property type="entry name" value="HOMEOBOX PROTEIN HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00025">
        <property type="entry name" value="ANTENNAPEDIA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00032">
        <property type="entry name" value="ANTENNAPEDIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0371">Homeobox</keyword>
    <keyword evidence="6 7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="11">
        <location>
            <begin position="253"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="7">
        <location>
            <begin position="255"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="37"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="152"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="312"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="155"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="218"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAB0800566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="336" mass="37668" checksum="7B759AF1AA799CB7" modified="2020-02-26" version="1">MSSYFANSYMPDMRNGGVVSAEHPHQHQHYGAAVQVPQGGGAVQSDPNSCGDPSVVGLRQGIPSHHYGGGPPAAGQPPQGMPYPRFPPYDRMDMRNPAYYGAQHQQMDGNQGYRPDSPTNLQMVSNGAPNGHQTPVVYASCKLQAAAVNHGGVLGSSTGSPPLDTSQGMSNHHMGHHMQEHPQHHPQGHHQQPHLLYGAQQSGNMHQQNAPHQQPSLQQQQQQQQQQQQQQQQTANNPAALPSPLYPWMRSQFERKRGRQTYTRYQTLELEKEFHFNRYLTRRRRIEIAHALCLTERQIKIWFQNRRMKWKKENKTKGEVGSETGGDDISPQGSPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ATS8</accession>
    <name>A0A5N4ATS8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein uS17</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">40S ribosomal protein S11</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PPYR_06524</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the universal ribosomal protein uS17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000004">
        <property type="protein sequence ID" value="KAB0800785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ATS8"/>
    <dbReference type="FunCoup" id="A0A5N4ATS8">
        <property type="interactions" value="1472"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4ATS8"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00364">
        <property type="entry name" value="Ribosomal_uS17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.1000:FF:000002">
        <property type="entry name" value="40S ribosomal protein S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000266">
        <property type="entry name" value="Ribosomal_uS17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028333">
        <property type="entry name" value="Ribosomal_uS17_arc/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019979">
        <property type="entry name" value="Ribosomal_uS17_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032440">
        <property type="entry name" value="Ribosomal_uS17_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006345">
        <property type="entry name" value="PRK08572.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03630">
        <property type="entry name" value="uS17_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S11 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744:SF9">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00366">
        <property type="entry name" value="Ribosomal_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16205">
        <property type="entry name" value="Ribosomal_S17_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00973">
        <property type="entry name" value="RIBOSOMALS17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00056">
        <property type="entry name" value="RIBOSOMAL_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS17 N-terminal" evidence="9">
        <location>
            <begin position="4"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0800785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="155" mass="18219" checksum="A59102C364AA1D55" modified="2020-02-26" version="1">MADQNERSFQHQPTVFLNRKKVLGGKKRKSLRYHRDVGLGFRTPREASDGTYIDKKCPFTGNVSIRGRILTGVVQKMKMQRTIVIRRDYLHYIRKYNRFEKRHRNMSVHLSPCFRDVEIGDIVTVGECRPLSKTVRFNVLKVTKQTGSKKSFKKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AV46</accession>
    <name>A0A5N4AV46_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Moesin/ezrin/radixin homolog 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PPYR_05487</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
            <location evidence="1">Adherens junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cell projection</location>
            <location evidence="4">Rhabdomere</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000003">
        <property type="protein sequence ID" value="KAB0801133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AV46"/>
    <dbReference type="FunCoup" id="A0A5N4AV46">
        <property type="interactions" value="19"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AV46"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016028">
        <property type="term" value="C:rhabdomere"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008092">
        <property type="term" value="F:cytoskeletal protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031032">
        <property type="term" value="P:actomyosin structure organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13192">
        <property type="entry name" value="FERM_C_FRMD3_FRMD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17102">
        <property type="entry name" value="FERM_F1_FRMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000002">
        <property type="entry name" value="Erythrocyte protein band 4.1-like 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.10:FF:000006">
        <property type="entry name" value="FERM domain-containing protein 5 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000798">
        <property type="entry name" value="Ez/rad/moesin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014847">
        <property type="entry name" value="FA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019747">
        <property type="entry name" value="FERM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018979">
        <property type="entry name" value="FERM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018980">
        <property type="entry name" value="FERM_PH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23280">
        <property type="entry name" value="4.1 G PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23280:SF32">
        <property type="entry name" value="FI22325P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08736">
        <property type="entry name" value="FA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09380">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09379">
        <property type="entry name" value="FERM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00935">
        <property type="entry name" value="BAND41"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00661">
        <property type="entry name" value="ERMFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01195">
        <property type="entry name" value="FA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01196">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00660">
        <property type="entry name" value="FERM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0965">Cell junction</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="503"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="FERM" evidence="7">
        <location>
            <begin position="14"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="323"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="323"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="334"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00043944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0801133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="570" mass="65093" checksum="D7EA4D6DBB599E38" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AVU3</accession>
    <name>A0A5N4AVU3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SLC26A/SulP transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_05702</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000003">
        <property type="protein sequence ID" value="KAB0801348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AVU3"/>
    <dbReference type="FunCoup" id="A0A5N4AVU3">
        <property type="interactions" value="206"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AVU3"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07042">
        <property type="entry name" value="STAS_SulP_like_sulfate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="SULFATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="297"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="331"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="369"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="396"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="425"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="SLC26A/SulP transporter" evidence="6">
        <location>
            <begin position="41"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0801348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="618" mass="67640" checksum="521D3F778C766F37" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AVX8</accession>
    <name>A0A5N4AVX8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DDE-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_05843</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000003">
        <property type="protein sequence ID" value="KAB0801489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AVX8"/>
    <dbReference type="InParanoid" id="A0A5N4AVX8"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15489">
        <property type="entry name" value="PHD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF74">
        <property type="entry name" value="POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
        <property type="entry name" value="HTH_psq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH psq-type" evidence="4">
        <location>
            <begin position="19"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="DDE-1" evidence="3">
        <location>
            <begin position="207"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="430"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="430"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0801489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="526" mass="60065" checksum="0F318515484476F6" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AW38</accession>
    <name>A0A5N4AW38_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_03771</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0801585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AW38"/>
    <dbReference type="OrthoDB" id="414982at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1800.10">
        <property type="entry name" value="His-Me finger endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038563">
        <property type="entry name" value="Endonuclease_7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511">
        <property type="entry name" value="PROTEIN CBG23764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511:SF12">
        <property type="entry name" value="RHO TERMINATION FACTOR N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="His-Me finger endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="2"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0801585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1409" mass="162910" checksum="FD8A6947E5E0F67D" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AW87</accession>
    <name>A0A5N4AW87_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">V-type proton ATPase 16 kDa proteolipid subunit c</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">V-type proton ATPase 21 kDa proteolipid subunit c''</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Vacuolar proton pump 16 kDa proteolipid subunit c</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PPYR_05852</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the V-ATPase proteolipid subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000003">
        <property type="protein sequence ID" value="KAB0801498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AW87"/>
    <dbReference type="FunCoup" id="A0A5N4AW87">
        <property type="interactions" value="858"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AW87"/>
    <dbReference type="OrthoDB" id="10264021at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18177">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6F_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18178">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6F_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.610:FF:000002">
        <property type="entry name" value="V-type proton ATPase proteolipid subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.610">
        <property type="entry name" value="lithium bound rotor ring of v- atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000245">
        <property type="entry name" value="ATPase_proteolipid_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10263">
        <property type="entry name" value="V-TYPE PROTON ATPASE PROTEOLIPID SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00122">
        <property type="entry name" value="VACATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="89"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="133"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="13">
        <location>
            <begin position="50"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="13">
        <location>
            <begin position="139"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00071448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAB0801498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="208" mass="21481" checksum="AF5A0CA3E682F076" modified="2020-02-26" version="1">MQALLGKIFIGSAVSIITVLTLYHVLTGKGERISVGWFLEDTSPYMWATIGIGLSVALSVVGAAAGIHTTGVSIIGGGVKAPRIKTKNLISVIFCEAVAIYGLITAIVLSGYLSDFSLKVAEENENVRSKNWMAGYLMFGSGVAVGFVNLFCGIAVGIVGSGAALADAANSALFVKILIVEIFGSAIGLFGLIVGIYMVAKVAMGDKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AWD2</accession>
    <name>A0A5N4AWD2_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Fatty acid desaturase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PPYR_03861</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">1611_PpyrPB1</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="12">The histidine box domains are involved in binding the catalytic metal ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0801675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AWD2"/>
    <dbReference type="InParanoid" id="A0A5N4AWD2"/>
    <dbReference type="OrthoDB" id="10260134at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004768">
        <property type="term" value="F:stearoyl-CoA 9-desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006636">
        <property type="term" value="P:unsaturated fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03505">
        <property type="entry name" value="Delta9-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015876">
        <property type="entry name" value="Acyl-CoA_DS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351">
        <property type="entry name" value="ACYL-COA DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351:SF21">
        <property type="entry name" value="GH07782P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00075">
        <property type="entry name" value="FACDDSATRASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="3 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid desaturase" evidence="14">
        <location>
            <begin position="81"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAB0801675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="358" mass="41823" checksum="7832E1C41D373F5D" modified="2020-02-26" version="1">MPPNSTDESNGNLKVSERKEYHREYSKKDAEWVNYAKKWDEIKHFVSQLKWFNIILLTTLHLAFVWAAIAFPWLQRKRLVLWNFVFSHLTGFGIGAGAHRLWCHRTYKAKLPLRVFLMLCYATAGHNPLFYWVRDHRVHHKFTDTDADPHNSKRGFFFSHVGWLFMKKHPDVKRKGKEIDMSDLWEDPVIRFHQKYFIPLTLTLGFILPAIVPPLVWGQDWFWSIISSAVGRYVFVLNITWLVNSAAHMWGTKPFDNSISPTDNKTVSMLSFGEGWHNYHHTFPWDYKAAELKYAGYNVSSVFIEFCGKMGWAYDLKSASPELIKKVVVKGGDGSHLVWGEEVPESEEDEIRKATKQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AWI4</accession>
    <name>A0A5N4AWI4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CN hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_03782</name>
        <name evidence="6" type="ORF">PPYR_03786</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0801596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0801600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AWI4"/>
    <dbReference type="InParanoid" id="A0A5N4AWI4"/>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040154">
        <property type="entry name" value="Biotinidase/VNN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043957">
        <property type="entry name" value="Vanin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10609:SF14">
        <property type="entry name" value="BIOTINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10609">
        <property type="entry name" value="BIOTINIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19018">
        <property type="entry name" value="Vanin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033494291" description="CN hydrolase domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="CN hydrolase" evidence="4">
        <location>
            <begin position="23"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0801596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0801600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="518" mass="57331" checksum="32825DDA6A039FF9" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AWW9</accession>
    <name>A0A5N4AWW9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">AN1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PPYR_03992</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0801806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AWW9"/>
    <dbReference type="FunCoup" id="A0A5N4AWW9">
        <property type="interactions" value="148"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AWW9"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1110.10:FF:000001">
        <property type="entry name" value="Zinc finger AN1-type containing 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1110.10">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035896">
        <property type="entry name" value="AN1-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050652">
        <property type="entry name" value="AN1_A20_ZnFinger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002653">
        <property type="entry name" value="Znf_A20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000058">
        <property type="entry name" value="Znf_AN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10634:SF149">
        <property type="entry name" value="AN1-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10634">
        <property type="entry name" value="AN1-TYPE ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01754">
        <property type="entry name" value="zf-A20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01428">
        <property type="entry name" value="zf-AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00259">
        <property type="entry name" value="ZnF_A20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00154">
        <property type="entry name" value="ZnF_AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118310">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51036">
        <property type="entry name" value="ZF_A20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51039">
        <property type="entry name" value="ZF_AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="A20-type" evidence="6">
        <location>
            <begin position="6"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="AN1-type" evidence="7">
        <location>
            <begin position="135"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="39"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="114"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0801806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="200" mass="21574" checksum="B67DF57B7A8EF8BA" modified="2020-02-26" version="1">MERESNPMQALCRSGCGFYGSPATDGLCSICYKEALKKKQQPPVSAPSPSAPVSNAQSLASLMDATTTAQPTIPPCLPTLTGSASSDVSNFKNSQEAHMEGVDEDINATCNSADTSGTTDFDSSSNDKDEDKEGKKKKNRCAICRKKVGLTGFECRCGGLFCGVHRYSDKHNCTFDYREMGAQEIRRNNPVVVGEKIKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AXB7</accession>
    <name>A0A5N4AXB7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nose resistant-to-fluoxetine protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PPYR_04152</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0801966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AXB7"/>
    <dbReference type="InParanoid" id="A0A5N4AXB7"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005599">
        <property type="entry name" value="GPI_mannosylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006621">
        <property type="entry name" value="Nose-resist-to-fluoxetine_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052728">
        <property type="entry name" value="O2_lipid_transport_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161:SF4">
        <property type="entry name" value="DROP DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161">
        <property type="entry name" value="O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03901">
        <property type="entry name" value="Glyco_transf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20146">
        <property type="entry name" value="NRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00703">
        <property type="entry name" value="NRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="144"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="232"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="318"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="700"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="868"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="929"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="955"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1001"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1033"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1065"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1106"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1146"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="domain" description="Nose resistant-to-fluoxetine protein N-terminal" evidence="9">
        <location>
            <begin position="549"/>
            <end position="687"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0801966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1187" mass="137537" checksum="8155A57743F4791F" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AXP9</accession>
    <name>A0A5N4AXP9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RCC1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_04283</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A5N4AXP9">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AXP9"/>
    <dbReference type="OrthoDB" id="16281at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058923">
        <property type="entry name" value="RCC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051625">
        <property type="entry name" value="Signaling_Regulatory_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22872">
        <property type="entry name" value="BTK-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22872:SF2">
        <property type="entry name" value="INHIBITOR OF BRUTON TYROSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25390">
        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="RCC1-like" evidence="4">
        <location>
            <begin position="767"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="780"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="834"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="887"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="937"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="257"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0802097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1513" mass="169207" checksum="B2F8974740BAC9EA" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AZ99</accession>
    <name>A0A5N4AZ99_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="17 20">Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase</fullName>
            <shortName evidence="20">GNT-I</shortName>
            <shortName evidence="20">GlcNAc-T I</shortName>
            <ecNumber evidence="17 20">2.4.1.101</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18 20">N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">PPYR_04666</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">1611_PpyrPB1</strain>
            <tissue evidence="21">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16 20">Initiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to hybrid and complex N-glycans.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19 20">
            <text>N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + UDP-N-acetyl-alpha-D-glucosamine = N(4)-{beta-D-GlcNAc-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11456"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="Rhea" id="RHEA-COMP:14368"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:60625"/>
            <dbReference type="EC" id="2.4.1.101"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="20">The cofactor is mostly bound to the substrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 20">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Perinuclear region</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 20">Golgi apparatus membrane</location>
            <topology evidence="1 20">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 20">Belongs to the glycosyltransferase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.101" evidence="17 20"/>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AZ99"/>
    <dbReference type="FunCoup" id="A0A5N4AZ99">
        <property type="interactions" value="1436"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AZ99"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003827">
        <property type="term" value="F:alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02514">
        <property type="entry name" value="GT13_GLCNAC-TI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.180.20:FF:000001">
        <property type="entry name" value="alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000055">
        <property type="entry name" value="Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.20">
        <property type="entry name" value="N-Acetylglucosaminyltransferase I, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004139">
        <property type="entry name" value="Glyco_trans_13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052261">
        <property type="entry name" value="Glycosyltransferase_13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10468:SF0">
        <property type="entry name" value="ALPHA-1,3-MANNOSYL-GLYCOPROTEIN 2-BETA-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10468">
        <property type="entry name" value="PROTEIN O-LINKED-MANNOSE BETA-1,2-N-ACETYLGLUCOSAMINYLTRANSFERASE 1/ALPHA-1,3-MANNOSYL-GLYCOPROTEIN 2-BETA-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03071">
        <property type="entry name" value="GNT-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 20" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12 20" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="15 20" id="KW-0464">Manganese</keyword>
    <keyword evidence="13 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 20" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 20" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00037706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00038949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00041712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU368119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAB0802480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="430" mass="50379" checksum="83DF4593B04B236A" modified="2020-02-26" version="1">MRMRRTYFLGFSFLIWILIIYITVKRHTLVVTDTTEEVDKGLKKLENGILEQFKINKNFISTLHSIIEAKKQDVSKENEVSTKREFKGTVIPVVVIACNRVSVNRCLDQLIQYRPNPDQFPIIVSQDCNHAETTEVIERYGSQVLLIKQPDQSEIDIPPKEKKFKGYFKIARHYGWALNQTFFNFNFDVAIIVEDDLNVAPDFFEYFSGTYPLLLKDPSLWCISAWNDNGKVGLINQDRPDLLYRSDFFPGLGWMLTKSLWVELCNKWPRAYWDDWIRSPEQRKDRACIRPEVSRTRTFGKIGVSNGLFFEKHLKYIKLNEVFVPFTKMNLSYLMKDIYDSEFVRTVYQSAVVSYQELKDNAITYDGSVRIIYHTRDVYKRTAKLLGLMDDFKSGVPRTGYKGIVTFNYKGRTVYLTPSLNWKGYDPTWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B0D3</accession>
    <name>A0A5N4B0D3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BESS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_00015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B0D3"/>
    <dbReference type="InParanoid" id="A0A5N4B0D3"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="107"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0803045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="168" mass="19460" checksum="8C01615F072AB548" modified="2020-02-26" version="1">MPFDNRCYVNLPLLQAPYNHFADEDKCLPKIQEAGKQMKEAFSSLSSIINKRPTEEDECDLYGKMLAKKLRKLPEEKRQLFIYEIDGLFIQRCRSLSFPSQHRPERSNTPSSSHSSNYSHSSYVSQSDTNYYSQPLPNLSHCGDNIATIPFIYTAEHCRCNNSQSKYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B0V5</accession>
    <name>A0A5N4B0V5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ammonium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PPYR_00199</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B0V5"/>
    <dbReference type="FunCoup" id="A0A5N4B0V5">
        <property type="interactions" value="6"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4B0V5"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097272">
        <property type="term" value="P:ammonium homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ammonium transporter AmtB like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00836">
        <property type="entry name" value="amt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11730">
        <property type="entry name" value="AMMONIUM TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11730:SF58">
        <property type="entry name" value="AMMONIUM TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111352">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="66"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="279"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="336"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="375"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium transporter AmtB-like" evidence="9">
        <location>
            <begin position="27"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0803229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="548" mass="59357" checksum="4FD1E305D532B3D0" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B161</accession>
    <name>A0A5N4B161_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">JNK1/MAPK8-associated membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_00308</name>
        <name evidence="3" type="ORF">PPYR_00311</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KAB0803341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="interactions" value="152"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4B161"/>
    <dbReference type="OrthoDB" id="5920264at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006986">
        <property type="term" value="P:response to unfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008485">
        <property type="entry name" value="JAMP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12740">
        <property type="entry name" value="JNK1/MAPK8-ASSOCIATED MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12740:SF4">
        <property type="entry name" value="JNK1_MAPK8-ASSOCIATED MEMBRANE PROTEIN"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF05571">
        <property type="entry name" value="JAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="268"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0803338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0803341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="299" mass="34139" checksum="6954C76C3A497193" modified="2020-02-26" version="1">MRCPGWYCGRTLLENASLGECGACPRGYRRNDSTFICDPCTDNPLFYDWLYLGFMVLLALVLHWFFIDLVVMRRNFNKEVIMLHCSAFIEIVLACVLTLLSTEPFGTLTIRSCAVRSLSDWYTLLHNPRPNYEKTVHCTQEAVYPLYTMVFVFFAYALILMLILRPWICKRCLPRQSKMSIYAAMYFLPILALLQALIGGLLYYSFPYLIVVLSVISCAAHFAAQIDQTVLSLIITTVVDLRNVIILIGHWCLHAYGIIAITQLTNPTLHALLILLVPLPALFYILTARFTDPSRFLPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B459</accession>
    <name>A0A5N4B459_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_01120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B459"/>
    <dbReference type="InParanoid" id="A0A5N4B459"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="entry name" value="Intergrase catalytic core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33480">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33480:SF1">
        <property type="entry name" value="TYR RECOMBINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0804150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="868" mass="99397" checksum="8E3738DF26D52B90" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B4B4</accession>
    <name>A0A5N4B4B4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_01427</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B4B4"/>
    <dbReference type="InParanoid" id="A0A5N4B4B4"/>
    <dbReference type="OrthoDB" id="8912104at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47501:SF5">
        <property type="entry name" value="HAT C-TERMINAL DIMERISATION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47501">
        <property type="entry name" value="TRANSPOSASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0804457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="544" mass="62047" checksum="BF27931281ACC41B" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-06-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B4L2</accession>
    <name>A0A5N4B4L2_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_01502</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B4L2"/>
    <dbReference type="InParanoid" id="A0A5N4B4L2"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0804532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="151" mass="17750" checksum="922C75F787D7B110" modified="2020-02-26" version="1">MEMDSDASFSCTPEEIVNAAGIATSNLLPEKSKDQYLKEYDLFMKWRTEKHVGSFSERVLLCYFEEKSKQWKPPTLWSTYSKLMATLLIHNNVDIRKYSKLIAYLKNKSVGHKPKKSRTFSRDEMYKFLHNAPDEQFLMHKVLAIWPLYAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B661</accession>
    <name>A0A5N4B661_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PPYR_02003</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0805033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B661"/>
    <dbReference type="FunCoup" id="A0A5N4B661">
        <property type="interactions" value="51"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4B661"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000077">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050430">
        <property type="entry name" value="Peptidase_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276:SF91">
        <property type="entry name" value="AT26814P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276">
        <property type="entry name" value="POLYSERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024388973" description="Peptidase S1 domain-containing protein" evidence="9">
        <location>
            <begin position="18"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="10">
        <location>
            <begin position="32"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0805033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="256" mass="27660" checksum="9CED939FDB898B57" modified="2020-02-26" version="1">MLKIVLVATIAALVAEASPMPRLQLPQLDGRIVGGVDTTIESYPHQVSVMYFDRHICGGSIIAHNLILTAAHCTRGKDAQFLNIRYGTSLRNQGGTVVAIAEIHDHPNYDPVTTDFDISVLKLSSDIDLSHTAQIIPMISVNAQEGGRTALVTGWGALYTDGPSPKQLQVVELKEEDRKACNKAYEGEITERMICFMNPGQDACQGDSGGPLISNGVQIGVVSWGYDCADPLYPGVFADLANVQIRDHIDGIVEMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B719</accession>
    <name>A0A5N4B719_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_02324</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0805354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B719"/>
    <dbReference type="InParanoid" id="A0A5N4B719"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0805354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="76" mass="8979" checksum="50C019F229DF7BAA" modified="2020-02-26" version="1">MSIYTQLGTIKSVDGDVDQDENIVMDTVEGVYKNEEEEGRVGRDKEKQRRPSAHRHRLRRHRWSKMPPHKGAIIYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B755</accession>
    <name>A0A5N4B755_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_02402</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0805432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B755"/>
    <dbReference type="InParanoid" id="A0A5N4B755"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0805432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="150" mass="17280" checksum="26B01B8D4A6C38E3" modified="2020-02-26" version="1">MRLEIAGKLKEGVSFEHILDSIRDAGITEEGFQRLQLLDRTDLRNIMKEFHIDYDTKHHENDAVSVTLWVEKMKMLGKECPVLFYKPQNIECESSILNPEDFALVIMTSFQSQQLLKFGHEKICIDGTHGTNSYDFQLYTVMTVDEFGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1K187</accession>
    <name>A0A1Y1K187_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">COP9 signalosome complex subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PPYR_09812</name>
        <name evidence="11" type="ORF">PPYR_10283</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CSN3 family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01097366">
        <property type="protein sequence ID" value="JAV54248.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0795751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1K187"/>
    <dbReference type="FunCoup" id="A0A1Y1K187">
        <property type="interactions" value="2282"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1K187"/>
    <dbReference type="OrthoDB" id="29061at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000354">
        <property type="entry name" value="COP9 signalosome complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.570:FF:000008">
        <property type="entry name" value="COP9 signalosome complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055089">
        <property type="entry name" value="COP9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050756">
        <property type="entry name" value="CSN3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3/COP9 SIGNALOSOME COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758:SF1">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22788">
        <property type="entry name" value="COP9_hel_rpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="PCI" evidence="8">
        <location>
            <begin position="204"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="JAV54248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0795751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0796222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="430" mass="48692" checksum="5287070D838403A3" modified="2017-08-30" version="1">MASALEQFVNTVRTLSSQGNYRDLCDYLSKSNEILIKNGQHLDNVLETLDIQQHSLGVLAVLNAKYNTPLVNATNENRFKQVKDFIFNCNGEQIRLAPDLFAELCHLVTANLTEQKQPIKGISLLQKAISKLQLYDSQLTSIHADLCQLCLLSKCFKPALEILDIDITGICQENVQGQSGSHFDAKYFLLYYYYGGMIYLALRNLDRALYFLEVAITTPAQEVSHIMLESYKKYILVSLLLHGKILVIPKYTSRVVNRFIKPLSQPYHELTNGFASNNSAELNMIVNKHNEVFARDHNLGLVKQVVSVLYKKNIQRLTKTFLTLSLSDVASRVGLASPNDAENYILHMIEDKQIYATINQKDGMVIFRDEPDKYGGPEVLKGLETQLQQCMELDKQILAMDEEIQVNPQYVKKATGLQEDEQPSKSAYAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1K3T6</accession>
    <name>A0A1Y1K3T6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ataxin-10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PPYR_00460</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">May play a role in the regulation of cytokinesis. May play a role in signaling by stimulating protein glycosylation. Induces neuritogenesis by activating the Ras-MAP kinase pathway and is necessary for the survival of cerebellar neurons. Does not appear to play a major role in ciliogenesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ataxin-10 family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01093810">
        <property type="protein sequence ID" value="JAV56112.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1K3T6"/>
    <dbReference type="FunCoup" id="A0A1Y1K3T6">
        <property type="interactions" value="1049"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1K3T6"/>
    <dbReference type="OrthoDB" id="379794at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031175">
        <property type="term" value="P:neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051374">
        <property type="entry name" value="Ataxin-10/CTR86_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019156">
        <property type="entry name" value="Ataxin-10_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13255">
        <property type="entry name" value="ATAXIN-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13255:SF0">
        <property type="entry name" value="ATAXIN-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09759">
        <property type="entry name" value="Atx10homo_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ataxin-10" evidence="6">
        <location>
            <begin position="360"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00045173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF09759"/>
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</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
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                <person name="Debat H.J."/>
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                <person name="Schmitz R.J."/>
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                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
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                <person name="Weng J.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01092660">
        <property type="protein sequence ID" value="JAV56503.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0805641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1K527"/>
    <dbReference type="InParanoid" id="A0A1Y1K527"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="JAV56503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0805641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="158" mass="17944" checksum="0E9F25F3B8E1AF1B" modified="2017-08-30" version="1">MSYAVSTPTRCEIFMKVFANPRSWLFFFGILLIAVLAITDSFKGVYEIWNVGEDSTTYPGVIINAYVILYITYLHIITITPMLRNLVCLFNLLVLTVLFRLAVFCTFIPIEKTAVAAVSSMIGCVMATMMVFGDFLFIEKWQKGVVEVIEIQDEEILE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1K6J6</accession>
    <name>A0A1Y1K6J6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tetraspanin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PPYR_12411</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the tetraspanin (TM4SF) family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01091225">
        <property type="protein sequence ID" value="JAV57000.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01091224">
        <property type="protein sequence ID" value="JAV57005.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01091223">
        <property type="protein sequence ID" value="JAV57008.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01091222">
        <property type="protein sequence ID" value="JAV57013.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0795572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1K6J6"/>
    <dbReference type="FunCoup" id="A0A1Y1K6J6">
        <property type="interactions" value="29"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1K6J6"/>
    <dbReference type="OrthoDB" id="10051815at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03127">
        <property type="entry name" value="tetraspanin_LEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1450.10">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000301">
        <property type="entry name" value="Tetraspanin_animals"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018503">
        <property type="entry name" value="Tetraspanin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282:SF28">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002419">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00259">
        <property type="entry name" value="TMFOUR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00421">
        <property type="entry name" value="TM4_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="JAV57013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0795572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="272" mass="30805" checksum="90187FE00BC6E252" modified="2017-08-30" version="1">MVRDIDIGMKCIKYMLFVSNFMFVMVGFLLISIGTTISSIYTDFELFMESHHFKPAQLIVVIGIIIFLVSLFGCIGAIRESTFLVNMFAVLLSILLVLEVSAAIAAYAMRSDIKESVEHNMYDALKDYNKTYDAKSSWDFMQYRLICCGVHQPSDWRNTNIIFEKNLTAPVSCCKYPRCETGVINTHGCLDRLTDIVSESALMLGVGSTCVALVQFLGVVFAFMLAKTIRRVKTEQEMRRQENRQRIYEQLAIGTEDKIVTPVLYTPQSTDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1KDA4</accession>
    <name>A0A1Y1KDA4_PHOPY</name>
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        <recommendedName>
            <fullName evidence="4">carbonyl reductase (NADPH)</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_11223</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.184" evidence="4"/>
    <dbReference type="EMBL" id="GEZM01088470">
        <property type="protein sequence ID" value="JAV58180.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0794384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1KDA4"/>
    <dbReference type="InParanoid" id="A0A1Y1KDA4"/>
    <dbReference type="OrthoDB" id="7289984at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004090">
        <property type="term" value="F:carbonyl reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd05324">
        <property type="entry name" value="carb_red_PTCR-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045313">
        <property type="entry name" value="CBR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43963:SF4">
        <property type="entry name" value="CARBONYL REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43963">
        <property type="entry name" value="CARBONYL REDUCTASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="JAV58180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0794384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="275" mass="30203" checksum="55270F4E14C5F29C" modified="2017-08-30" version="1">MKAVAVVTGGNKGIGYAIAKGLCEKFSGNVYLTARNEALGLNAVAKLKELGLNPLFHQLDVNDQASIDKFRDYIKNAEGGIDILVNNAAIAFPQVTSVPFSKQAEETIAVNYFGTLRVCETLFPILRQSAKVVNVSSSAGHLFRIPSPDIRAKLSEASLTIEKLSEYMREFVEAAKMNVNSEKGWGNSAYVVSKVGVSALTNVQQRLFDEENEHRNIMVNSVHPGYVDTDMTNHKGVLTIEEGAKAPLYLALEDHGLRGKFVWNDSKVVDWFQPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1KDC5</accession>
    <name>A0A1Y1KDC5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">b(0,+)-type amino acid transporter 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Glycoprotein-associated amino acid transporter b0,+AT1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Solute carrier family 7 member 9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">PPYR_07089</name>
    </gene>
    <organism evidence="21">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="22 23" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">1611_PpyrPB1</strain>
            <tissue evidence="22">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">1611_PpyrPB1</strain>
            <tissue evidence="22">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-phenylalanine(out) + L-arginine(in) = L-phenylalanine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:71067"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:71068"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-cysteine(out) + L-arginine(in) = L-cysteine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:71071"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:71072"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-cystine(out) + L-arginine(in) = L-cystine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:71075"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:35491"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:71076"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-histidine(out) + L-arginine(in) = L-histidine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:71063"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:71064"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-leucine(out) + L-arginine(in) = L-leucine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:71059"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:71060"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-lysine(out) + L-arginine(in) = L-lysine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:70827"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:70828"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Apical cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01086365">
        <property type="protein sequence ID" value="JAV59513.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="interactions" value="174"/>
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    <dbReference type="InParanoid" id="A0A1Y1KDC5"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="B(0,+)-type amino acid transporter 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF512">
        <property type="entry name" value="SOBREMESA, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
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    <keyword evidence="8 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
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    <keyword evidence="7 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="224"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="262"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="301"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="342"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="395"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="422"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="456"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="481"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="38"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004424"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009523"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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    </evidence>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00052732"/>
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        <source>
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        <source>
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    <evidence type="ECO:0000256" key="17">
        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00093193"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="JAV59513.1"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAB0799209.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="2">Galectin</fullName>
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    <organism evidence="6">
        <name type="scientific">Photinus pyralis</name>
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            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
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            <taxon>Coleoptera</taxon>
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            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
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            <dbReference type="DOI" id="10.1038/srep38556"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
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            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
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    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="6251307at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0030246">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:0016936">
        <property type="term" value="F:galactoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="InterPro" id="IPR001079">
        <property type="entry name" value="Galectin_CRD"/>
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    <dbReference type="PANTHER" id="PTHR11346:SF176">
        <property type="entry name" value="32 KDA BETA-GALACTOSIDE-BINDING LECTIN LEC-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11346">
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
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    <dbReference type="PROSITE" id="PS51304">
        <property type="entry name" value="GALECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0430">Lectin</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="257"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Galectin" evidence="5">
        <location>
            <begin position="12"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="174"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU102079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="JAV61869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0804006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="304" mass="34006" checksum="C510E75DD130A8BB" modified="2017-08-30" version="1">MEEPIRDPSIPYVGVIAGRFTPGKIIRIQGAVPGIAYRFDINLQCGPETRPRDDIAMHLSVRFLDGFIAMNSLQNGIWGEVVHGNTQPVKRAEQFEILIMCDFNKYKIVINDQLFYDFPQRIHYDSISYLTIEGDVTIANITYGSQNSLPTLPRPGPVPVIRRPPDNDFEIVNGPDHSQPPSYSEVVHNLPPKGQPYPMKSSPYNPGMTAPYPTASSSFPSPSAPNLTLPAGMPVPLNAASSNFRPVQKTNTKKYCGYFWSVVIGIIIVVAVIVSKTKTTHTTKSSSHYDYYQNNNNRYTDNWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1KQX6</accession>
    <name>A0A1Y1KQX6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">nicotinamidase</fullName>
            <ecNumber evidence="7">3.5.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Nicotinamide deamidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PPYR_05548</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="6">Cofactor biosynthesis; nicotinate biosynthesis; nicotinate from nicotinamide: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.19" evidence="7"/>
    <dbReference type="EMBL" id="GEZM01078914">
        <property type="protein sequence ID" value="JAV62580.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000003">
        <property type="protein sequence ID" value="KAB0801194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1KQX6"/>
    <dbReference type="FunCoup" id="A0A1Y1KQX6">
        <property type="interactions" value="13"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1KQX6"/>
    <dbReference type="OrthoDB" id="167809at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008936">
        <property type="term" value="F:nicotinamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019363">
        <property type="term" value="P:pyridine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01011">
        <property type="entry name" value="nicotinamidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052347">
        <property type="entry name" value="Isochorismatase_Nicotinamidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11080:SF2">
        <property type="entry name" value="LD05707P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11080">
        <property type="entry name" value="PYRAZINAMIDASE/NICOTINAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="9">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="9">
        <location>
            <begin position="39"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00043224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="JAV62580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0801194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="329" mass="37487" checksum="C127643F9B743743" modified="2017-08-30" version="1">MDACFTAFDKNGDGKLDLEEFKLICRALFRNDKGKIYSLQENKVREIFNVFDKNNDNFIDREEFTFCWNHWIKIIVRPISAFLIVDVQNDFISGTLNISNCSAQQNGAEVIEPINRLLDTVNFDAVFYSLDWHPSDHISFIDNLHMRELDPSSPLTVETANTYDTVIFSGPTPMKQRLWPRHCVQDTWGSELHQDLKILEKAIKVYKGTNPEVDSYSVFWDNKKLTDTTLCGQLRLKNATDIYICGLAYDVCVGATAVDALAIGYRTILLDDCSRGVDLLDIEKTKTTVIKNNGVIVNSNHVKAMVEGRDRRPELGYKLAMELKSNSSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1KRF7</accession>
    <name>A0A1Y1KRF7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phosphatidylinositol-3,5-bisphosphate 3-phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.95</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PPYR_06173</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">1611_PpyrPB1</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">1611_PpyrPB1</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.95" evidence="4"/>
    <dbReference type="EMBL" id="GEZM01078343">
        <property type="protein sequence ID" value="JAV62760.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000004">
        <property type="protein sequence ID" value="KAB0800433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1KRF7"/>
    <dbReference type="FunCoup" id="A0A1Y1KRF7">
        <property type="interactions" value="623"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1KRF7"/>
    <dbReference type="OrthoDB" id="271628at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052629">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004438">
        <property type="term" value="F:phosphatidylinositol-3-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13357">
        <property type="entry name" value="PH-GRAM_MTMR2_insect-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14535">
        <property type="entry name" value="PTP-MTM1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000038">
        <property type="entry name" value="Myotubularin 1, isoform CRA_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004182">
        <property type="entry name" value="GRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030564">
        <property type="entry name" value="Myotubularin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010569">
        <property type="entry name" value="Myotubularin-like_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
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</entry>
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                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
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                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
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</entry>
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    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
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            <authorList>
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                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Trimers of two alpha 1(IV) and one alpha 2(IV) chain. Type IV collagen forms a mesh-like network linked through intermolecular interactions between 7S domains and between NC1 domains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
            <location evidence="1">Basement membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GEZM01070756">
        <property type="protein sequence ID" value="JAV66296.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1L3Y9"/>
    <dbReference type="OrthoDB" id="10071882at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005604">
        <property type="term" value="C:basement membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:collagen trimer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005201">
        <property type="term" value="F:extracellular matrix structural constituent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009792">
        <property type="term" value="P:embryo development ending in birth or egg hatching"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.240.10:FF:000001">
        <property type="entry name" value="Collagen IV alpha 1 chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.240.10">
        <property type="entry name" value="Collagen IV, non-collagenous"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
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    <dbReference type="InterPro" id="IPR001442">
        <property type="entry name" value="Collagen_IV_NC"/>
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    <dbReference type="InterPro" id="IPR036954">
        <property type="entry name" value="Collagen_IV_NC_sf"/>
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    <dbReference type="InterPro" id="IPR050149">
        <property type="entry name" value="Collagen_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24023">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24023:SF1082">
        <property type="entry name" value="COLLAGEN TRIPLE HELIX REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01413">
        <property type="entry name" value="C4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00111">
        <property type="entry name" value="C4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51403">
        <property type="entry name" value="NC1_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0084">Basement membrane</keyword>
    <keyword evidence="6" id="KW-0176">Collagen</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033750352" description="Collagen IV NC1 domain-containing protein" evidence="10">
        <location>
            <begin position="31"/>
            <end position="2043"/>
        </location>
    </feature>
    <feature type="domain" description="Collagen IV NC1" evidence="11">
        <location>
            <begin position="1531"/>
            <end position="1756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="67"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="258"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="304"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="386"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="441"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="577"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="804"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="982"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1097"/>
            <end position="1181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1386"/>
            <end position="1416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1467"/>
            <end position="1502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1511"/>
            <end position="1530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1758"/>
            <end position="2043"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="91"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="171"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="184"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="594"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1812"/>
            <end position="1884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1885"/>
            <end position="1896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1897"/>
            <end position="1949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1990"/>
            <end position="1999"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="2000"/>
            <end position="2011"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="2016"/>
            <end position="2027"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="2028"/>
            <end position="2043"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00064856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="JAV66296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAB0797429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="2043" mass="205108" checksum="141FEE81C886CE5E" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1L5P3</accession>
    <name>A0A1Y1L5P3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Lysosome-associated membrane glycoprotein 5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Lysosome-associated membrane protein 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">PPYR_08914</name>
    </gene>
    <organism evidence="26">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="27 28" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">1611_PpyrPB1</strain>
            <tissue evidence="27">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="27" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="27">1611_PpyrPB1</strain>
            <tissue evidence="27">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Plays a role in short-term synaptic plasticity in a subset of GABAergic neurons in the brain.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell projection</location>
            <location evidence="4">Dendrite</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="17">Cell projection</location>
            <location evidence="17">Growth cone membrane</location>
            <topology evidence="17">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Cytoplasmic vesicle</location>
            <location evidence="15">Secretory vesicle</location>
            <location evidence="15">Synaptic vesicle membrane</location>
            <topology evidence="15">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Early endosome membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum-Golgi intermediate compartment membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="20">Membrane</location>
            <topology evidence="20">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Recycling endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 20">Belongs to the LAMP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01068591">
        <property type="protein sequence ID" value="JAV66876.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1L5P3"/>
    <dbReference type="FunCoup" id="A0A1Y1L5P3">
        <property type="interactions" value="490"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1L5P3"/>
    <dbReference type="OrthoDB" id="6232933at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072594">
        <property type="term" value="P:establishment of protein localization to organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12087">
        <property type="entry name" value="TM_EGFR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048528">
        <property type="entry name" value="Lamp2-like_luminal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048524">
        <property type="entry name" value="Lamp2-like_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002000">
        <property type="entry name" value="Lysosome-assoc_membr_glycop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11506">
        <property type="entry name" value="LYSOSOME-ASSOCIATED MEMBRANE GLYCOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11506:SF35">
        <property type="entry name" value="LYSOSOME-ASSOCIATED MEMBRANE GLYCOPROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01299">
        <property type="entry name" value="Lamp2-like_luminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21222">
        <property type="entry name" value="Lamp2_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51407">
        <property type="entry name" value="LAMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0966">Cell projection</keyword>
    <keyword evidence="14" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="8" id="KW-0967">Endosome</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 20 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 23" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0770">Synapse</keyword>
    <keyword evidence="6 20 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 22" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="23">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036029795" description="Lysosome-associated membrane glycoprotein 5" evidence="23">
        <location>
            <begin position="19"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="279"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Lysosome-associated membrane glycoprotein 2-like luminal" evidence="24">
        <location>
            <begin position="106"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Lysosome-associated membrane glycoprotein 2-like transmembrane" evidence="25">
        <location>
            <begin position="280"/>
            <end position="308"/>
        </location>
    </feature>
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        <location>
            <begin position="22"/>
            <end position="101"/>
        </location>
    </feature>
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        <location>
            <begin position="31"/>
            <end position="59"/>
        </location>
    </feature>
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        <location>
            <begin position="60"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004158"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
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            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00074379"/>
        </source>
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            <dbReference type="ARBA" id="ARBA00076257"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
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            <dbReference type="Pfam" id="PF01299"/>
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        <source>
            <dbReference type="Pfam" id="PF21222"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="JAV66876.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAB0797921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="314" mass="33931" checksum="BD0D17BCD1497D4D" modified="2017-08-30" version="1">MAKLLLFVISAVLIAVQAEVFPPQPPPPPQNSTSTSTTSTTQAPITTSTKPTSTTKTTPAPVPPKPTPSPTPKPTPSPTPKPEPAPEPPKPSDPQQGTWHYTETTSTSNVTCIKIQFALQIVVPYFHKSRNKTYNATVNVPTNAVVADAACGNETEHLKLQWMNKDNATDTVLFKFANNATAKEYELQSIEINLYPDDDAFPGIENKNVIRLNHDHSEFVTGESNSYKCEKEQKLNLTDAGKETGFAGISHLQVQAFGTTNSDAFKSAIDCDASSTPDVVPIAVGCALAILVIVVLVAYLIGRKRRQARGYLSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1L9Q9</accession>
    <name>A0A1Y1L9Q9_PHOPY</name>
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        <recommendedName>
            <fullName evidence="11">P-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PPYR_10343</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
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        <property type="protein sequence ID" value="JAV70401.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
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        <property type="molecule type" value="Transcribed_RNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:alpha-1,4-glucosidase activity"/>
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        <property type="term" value="F:carbohydrate binding"/>
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        <property type="entry name" value="GH31_MGAM_SI_GAA"/>
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        <property type="entry name" value="Maltase-glucoamylase, intestinal"/>
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        <property type="entry name" value="Glycosidases"/>
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        <property type="entry name" value="Golgi alpha-mannosidase II"/>
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        <property type="entry name" value="Spasmolytic Protein, domain 1"/>
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    </dbReference>
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        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
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    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
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        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
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        <property type="entry name" value="Glyco_hydro_31_CS"/>
    </dbReference>
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        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000519">
        <property type="entry name" value="P_trefoil_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044913">
        <property type="entry name" value="P_trefoil_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF131">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 31 N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Trefoil"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00018">
        <property type="entry name" value="PD"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Galactose mutarotase-like"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="P_TREFOIL_2"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
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        <location>
            <begin position="81"/>
            <end position="103"/>
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    </feature>
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        <location>
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            <end position="213"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="JAV70402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAB0796282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1019" mass="116401" checksum="3B047D27FB23E9A7" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LDN3</accession>
    <name>A0A1Y1LDN3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PPYR_08600</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">1611_PpyrPB1</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">1611_PpyrPB1</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01062490">
        <property type="protein sequence ID" value="JAV69684.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01062489">
        <property type="protein sequence ID" value="JAV69686.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01062488">
        <property type="protein sequence ID" value="JAV69688.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1LDN3"/>
    <dbReference type="InParanoid" id="A0A1Y1LDN3"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:004176">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000373">
        <property type="entry name" value="Putative transcriptional repressor ctcf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002321">
        <property type="entry name" value="Putative transcriptional repressor ctcf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000448">
        <property type="entry name" value="RE1-silencing transcription factor A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001668">
        <property type="entry name" value="transcriptional repressor CTCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002596">
        <property type="entry name" value="Transcriptional repressor CTCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000255">
        <property type="entry name" value="Zinc finger and AT-hook domain containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000770">
        <property type="entry name" value="zinc finger protein 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050752">
        <property type="entry name" value="C2H2-ZF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24384:SF189">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24384">
        <property type="entry name" value="FINGER PUTATIVE TRANSCRIPTION FACTOR FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="210"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="238"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="266"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="295"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="323"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="351"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="381"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="410"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="438"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="466"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="503"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="649"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="651"/>
            <end position="660"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="JAV69686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAB0797607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="678" mass="76835" checksum="E6D807EF6D5D57A1" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LDT2</accession>
    <name>A0A1Y1LDT2_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Paramyosin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PPYR_10854</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Paramyosin is a major structural component of many thick filaments isolated from invertebrate muscles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Myofibril</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the paramyosin family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01061383">
        <property type="protein sequence ID" value="JAV70510.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1LDT2"/>
    <dbReference type="FunCoup" id="A0A1Y1LDT2">
        <property type="interactions" value="264"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1LDT2"/>
    <dbReference type="OrthoDB" id="2018427at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030016">
        <property type="term" value="C:myofibril"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032982">
        <property type="term" value="C:myosin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030239">
        <property type="term" value="P:myofibril assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.340:FF:000035">
        <property type="entry name" value="Paramyosin, long form"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002928">
        <property type="entry name" value="Myosin_tail"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46349">
        <property type="entry name" value="CINGULIN-LIKE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46349:SF6">
        <property type="entry name" value="MYOSIN-6-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01576">
        <property type="entry name" value="Myosin_tail_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90257">
        <property type="entry name" value="Myosin rod fragments"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0505">Motor protein</keyword>
    <keyword evidence="9" id="KW-0514">Muscle protein</keyword>
    <keyword evidence="7" id="KW-0518">Myosin</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0787">Thick filament</keyword>
    <feature type="domain" description="Myosin tail" evidence="12">
        <location>
            <begin position="32"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="172"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="813"/>
            <end position="847"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="JAV70510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAB0796793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="873" mass="102188" checksum="A9F121D18AE6468D" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LEM5</accession>
    <name>A0A1Y1LEM5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_00624</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GEZM01057951">
        <property type="protein sequence ID" value="JAV72073.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="InParanoid" id="A0A1Y1LEM5"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:nucleus"/>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="entry name" value="polyadenylate-binding protein 2"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
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        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
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        <property type="entry name" value="EUKARYOTIC INITIATION FACTOR 4B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RRM_1"/>
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    </dbReference>
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    </dbReference>
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        <location>
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        </location>
    </feature>
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            <begin position="1"/>
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    </feature>
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    </feature>
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        <location>
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            <end position="74"/>
        </location>
    </feature>
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        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="JAV72073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0803654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="226" mass="25078" checksum="97EDB20C4E3AE55F" modified="2017-08-30" version="1">MAETEDLGLGSEDHLDGLDENGVNDEALLNDTDGDGGGADDPELEAIKARVREMEEEAEKLKQLQNEVDKQMNMGSPPGLTSPLNMSFEEKMEVDNRSIYVGNVDYGATAEELEQHFHGCGSINRVTILCNKYDGHPKGFAYIEFGDRDSLQTAMAMDESIFRGRQIKVMPKRTNRPGVSSTNRPPRGSRFRGGGRGAITRGGYYGGFRPTRRPRSYRRGGYFAPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LEQ7</accession>
    <name>A0A1Y1LEQ7_PHOPY</name>
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        <recommendedName>
            <fullName evidence="12">KRR1 small subunit processome component</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">KRR-R motif-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PPYR_07177</name>
        <name evidence="17" type="ORF">PPYR_10842</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
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            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17 19" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">1611_PpyrPB1</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">1611_PpyrPB1</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly. Binds to RNA. Required for female germline development, cell viability during eye development and for survival of dividing cells and epithelial cells during early wing disk development.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Monomer. Component of the ribosomal small subunit (SSU) processome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
            <location evidence="1 12">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the KRR1 family.</text>
    </comment>
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        <property type="protein sequence ID" value="JAV72129.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KAB0799297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1LEQ7"/>
    <dbReference type="FunCoup" id="A0A1Y1LEQ7">
        <property type="interactions" value="1648"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1LEQ7"/>
    <dbReference type="OrthoDB" id="441223at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22393">
        <property type="entry name" value="KH-I_KRR1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22394">
        <property type="entry name" value="KH-I_KRR1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000011">
        <property type="entry name" value="KRR1 small subunit processome component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000014">
        <property type="entry name" value="KRR1 small subunit processome component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041174">
        <property type="entry name" value="KRR1-like_KH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048550">
        <property type="entry name" value="KRR1-like_KH1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048548">
        <property type="entry name" value="KRR1-like_KH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048549">
        <property type="entry name" value="KRR1-like_KH2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024166">
        <property type="entry name" value="rRNA_assembly_KRR1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12581">
        <property type="entry name" value="HIV-1 REV BINDING PROTEIN 2, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12581:SF0">
        <property type="entry name" value="KRR1 SMALL SUBUNIT PROCESSOME COMPONENT HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17903">
        <property type="entry name" value="KH_KRR1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21800">
        <property type="entry name" value="KH_KRR1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006515">
        <property type="entry name" value="KRR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="8 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 12" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="6 12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 12" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="KRR1 small subunit processome component first KH" evidence="14">
        <location>
            <begin position="41"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="KRR1 small subunit processome component second KH" evidence="15">
        <location>
            <begin position="124"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="233"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="296"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="235"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="309"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR006515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF21800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="JAV72129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAB0796781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAB0799297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="341" mass="39612" checksum="B8DAC968A9FF785C" modified="2017-08-30" version="1">MTESDVELEKPSHTAPLENAWQMKLPKFKAEHNPHGLLEESSFATLFPQYREQYLRQIWPLVEKTLGEHFIKAELDVVEGSMTVRTTRKTWDPYIIIKARDMIKLMSRSVPFEQAKRVLEDDVGCDIIKIGKITTNKDKFIKRRLRLIGPNGCTLKSIELLTNCYVLVQGQTVSALGPYKGLQQVRKIVEDTMKNVHPIYNIKALMIKRELAKDPKLKNENWERFLPKFVNQNISKRKQPKKKREKGPYTPFPPRQMESKIDKMLESGEYFLSAQQRRIKQQKAMTEKQMIATKLREEKRNQAFVPPKEQSTTKASASDTSVNLEKLKAKIKKAQKGKLNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LI72</accession>
    <name>A0A1Y1LI72_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">G/T mismatch-specific thymine DNA glycosylase</fullName>
            <ecNumber evidence="15">3.2.2.29</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Thymine-DNA glycosylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">PPYR_06582</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="21 22" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">1611_PpyrPB1</strain>
            <tissue evidence="21">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">1611_PpyrPB1</strain>
            <tissue evidence="21">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Hydrolyzes mismatched double-stranded DNA and polynucleotides, releasing free thymine.</text>
            <dbReference type="EC" id="3.2.2.29"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="14">Homodimer. Interacts with AICDA and GADD45A.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the uracil-DNA glycosylase (UDG) superfamily. TDG/mug family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.29" evidence="15"/>
    <dbReference type="EMBL" id="GEZM01060091">
        <property type="protein sequence ID" value="JAV71270.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01060090">
        <property type="protein sequence ID" value="JAV71274.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01060088">
        <property type="protein sequence ID" value="JAV71276.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01060087">
        <property type="protein sequence ID" value="JAV71278.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000004">
        <property type="protein sequence ID" value="KAB0800843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1LI72"/>
    <dbReference type="InParanoid" id="A0A1Y1LI72"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141016">
        <property type="term" value="F:G/T mismatch-specific thymine-DNA glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032183">
        <property type="term" value="F:SUMO binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd10028">
        <property type="entry name" value="UDG-F2_TDG_MUG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.470.10:FF:000002">
        <property type="entry name" value="G/T mismatch-specific thymine DNA glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="entry name" value="Uracil-DNA glycosylase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017956">
        <property type="entry name" value="AT_hook_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015637">
        <property type="entry name" value="MUG/TDG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12159">
        <property type="entry name" value="G/T AND G/U MISMATCH-SPECIFIC DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12159:SF9">
        <property type="entry name" value="G_T MISMATCH-SPECIFIC THYMINE DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00384">
        <property type="entry name" value="AT_hook"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00987">
        <property type="entry name" value="UreE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="Uracil-DNA glycosylase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Uracil-DNA glycosylase-like" evidence="19">
        <location>
            <begin position="180"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="400"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="455"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="504"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="540"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="581"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00061261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00064519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00066769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00071248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00083221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="JAV71276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAB0800843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="741" mass="81670" checksum="9E4DB446209510DE" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LM03</accession>
    <name>A0A1Y1LM03_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_08728</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01055769">
        <property type="protein sequence ID" value="JAV72945.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1LM03"/>
    <dbReference type="InParanoid" id="A0A1Y1LM03"/>
    <dbReference type="OrthoDB" id="8169913at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902936">
        <property type="term" value="F:phosphatidylinositol bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1200">
        <property type="entry name" value="Alpha-tocopherol transfer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.20">
        <property type="entry name" value="N-terminal domain of phosphatidylinositol transfer protein sec14p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174">
        <property type="entry name" value="ALPHA-TOCOPHEROL TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174:SF216">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00180">
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAB0797735.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="310" mass="36235" checksum="1850FBE535E1DF60" modified="2017-08-30" version="1">MYRQLNKVLQKVAEIELNETSSRIASDFDHIRQWMEKQPHLNFEIEDQMLLSFLRCSKFSLERTKERIDCYYTMRTLSPEIYTNRDPLLPEIQLILDTGVLLPLPKPLSDDGPRLLLFTYGSKLNPETMTVSNVIKTMYMIVDILVKEDDRCVIGGINTWSTVKNLPAKYVFHLTAPLIKKYITIAQNGTPIRLKGMYATECPPIFQYVYEVCKLFFTKKLSDRMSIYAQTDCKEFYEKIPKHLMPEEYGGSNGSVKQLTVEWKRKVESYRDWLMKDEERKSNEDLRLGSPRTSSDVFGMEGSFRKLDID</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LNS5</accession>
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        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
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            <taxon>Metazoa</taxon>
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            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
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            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
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    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
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                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
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            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">1611_PpyrPB1</strain>
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        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">1611_PpyrPB1</strain>
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        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Su(H) family.</text>
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    </dbReference>
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    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RBP-J/Cbf11/Cbf12_DNA-bd"/>
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    </dbReference>
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        <property type="entry name" value="RBP-Jkappa_IPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10665">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RBP-J/Cbf11/Cbf12 DNA binding" evidence="12">
        <location>
            <begin position="62"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-trefoil DNA-binding" evidence="13">
        <location>
            <begin position="195"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00009704"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM01268"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="JAV75279.1"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="507" mass="56911" checksum="EA10DC9F636472FC" modified="2017-08-30" version="1">MPHQYGLPGIAHAQSPPTPPPQHGAMYSRFTGAVVPGGYRGEGRKLTREAMERYLRERSDMVVVILHAKVAQKSYGNEKRFFCPPPCIYLFGDGWRLRQEQMLREGESEQAAQLCAFIGIGNSDQDMQQLDLNNGKQYCAAKTLYISDSDKRKHFMLSVKMFYGSGHDIGVFHSKRIKVISKPSKKKQSLKNADLCIASGTKVALFNRLRSQTVSTRYLHVENGHFHASSTQWGAFTIHLLDDNESESEEFQVRDGYIHYGATVKLVCSVTGMALPRLIIRKVDKQQALLEADDPVSQLHKCAFFMKDTERMYLCLSQERIIQFQATPCPKEPNKEMINDGACWTIISTDKAEYQFYEGMGPVRNPVTPVPLVHSLHLNGGGDVAMLELTGDNFSPSLQVWFGDVEAETMYRCQESMLCVVPDISQFRGEWLWVRQPTQVPVSLVRNDGIIYATGLTFTYTPEPGPRPHCPPADEIMHRPGRGNAAPTAAVTMTQSDTSVWNQAGMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LPE8</accession>
    <name>A0A1Y1LPE8_PHOPY</name>
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            <fullName evidence="1">CYTH domain-containing protein</fullName>
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    <organism evidence="2">
        <name type="scientific">Photinus pyralis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
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            <taxon>Elateroidea</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
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                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01051550">
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        <property type="molecule type" value="Transcribed_RNA"/>
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        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
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    </dbReference>
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        <property type="molecule type" value="Transcribed_RNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="JAV74811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0797300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="168" mass="18958" checksum="F290718DEACC989F" modified="2017-08-30" version="1">MRNVEIKAKVRNLHNLLVKAKLISESEGKVIPQVDQFYNSIQGRLKLRKFEDGSGELIYYDRPDDEGPKVSSYEKCAVDANLAELDRVLQCSLGSKGIVKKVRHLFMIGQTRLHVDIVEQLGNFMELEVVLNPEQSVEEGVAIANDLMEKLEIGKEDLLVGAYRDMLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LPU7</accession>
    <name>A0A1Y1LPU7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">RuvB-like helicase</fullName>
            <ecNumber evidence="14">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PPYR_12090</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">1611_PpyrPB1</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">1611_PpyrPB1</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 14">Proposed core component of the chromatin remodeling Ino80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the RuvB family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="14"/>
    <dbReference type="EMBL" id="GEZM01050187">
        <property type="protein sequence ID" value="JAV75682.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0795251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1LPU7"/>
    <dbReference type="FunCoup" id="A0A1Y1LPU7">
        <property type="interactions" value="1684"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1LPU7"/>
    <dbReference type="OrthoDB" id="10060499at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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        <property type="term" value="F:hydrolase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="P:cell division"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:DNA repair-dependent chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="term" value="P:negative regulation of signal transduction"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060828">
        <property type="term" value="P:regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042127">
        <property type="term" value="P:regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000010">
        <property type="entry name" value="RuvB-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.360:FF:000001">
        <property type="entry name" value="RuvB-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.360">
        <property type="entry name" value="RuvB-like helicase, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027238">
        <property type="entry name" value="RuvB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041048">
        <property type="entry name" value="RuvB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042487">
        <property type="entry name" value="RuvBL1/2_DNA/RNA_bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010339">
        <property type="entry name" value="TIP49_P-loop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11093">
        <property type="entry name" value="RUVB-RELATED REPTIN AND PONTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06068">
        <property type="entry name" value="TIP49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17856">
        <property type="entry name" value="TIP49_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="14" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 14" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 14" id="KW-0804">Transcription</keyword>
    <keyword evidence="9 14" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="15">
        <location>
            <begin position="62"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="JAV75682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAB0795251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="456" mass="49852" checksum="CFB8289C7E23FF47" modified="2017-08-30" version="1">MKVEEVKSTVKTQRISAHSHIKGLGLDENGIPIQMAAGLVGQEQAREAAGIVVDMIKTKKMAGRAILLAGPPGTGKTAIALAIAQDLGTKVPFCPMVGSEVYSSEIKKTEVLMENFRRAIGLRIRETKEVYEGEVTELTPVETESPAGGYGKTVNHVIIGLRTAKGSKQLKLDPSIYEALQKEKVEVGDVIYIEANSGAVKRQGRSDAFATEFDLEAEEYVPLPKGDVHKKKEVVQDVTLHDLDAANAKPQGGQDVLSMMGQLLKPKKTEITDKLRREINKVVDKYIDQGIAELVPGVLFIDEVHMLDIETFTYLHRALESAIAPIVIFATNRGRCVIRGTDDIVAPHGIPLDLLDRLVIIRTLPYTKPELEQILALRVATEGLDIDSDALKCLGDVGARSTLRYAVQLLTPASLTAKTNGRKNINKQDIEEVSSLFLDAKSSAKILTLNKEKYML</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1M2Q0</accession>
    <name>A0A1Y1M2Q0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Acyltransferase 3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PPYR_01289</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
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                <person name="Debat H.J."/>
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                <person name="Schmitz R.J."/>
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                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
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                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">1611_PpyrPB1</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">1611_PpyrPB1</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
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        <property type="protein sequence ID" value="JAV83533.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="JAV83537.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="JAV83539.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01034911">
        <property type="protein sequence ID" value="JAV83542.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01034910">
        <property type="protein sequence ID" value="JAV83544.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
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        <property type="protein sequence ID" value="JAV83547.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
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        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
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        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="JAV83554.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
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        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="JAV83559.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
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        <property type="protein sequence ID" value="JAV83561.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="InParanoid" id="A0A1Y1MJT1"/>
    <dbReference type="OrthoDB" id="1095242at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990837">
        <property type="term" value="F:sequence-specific double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="Zinc finger and SCAN domain-containing protein 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000478">
        <property type="entry name" value="Zinc finger protein 133"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zinc finger protein 236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
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    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001498">
        <property type="entry name" value="Zinc finger protein 404"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000303">
        <property type="entry name" value="Zinc finger protein 41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000495">
        <property type="entry name" value="zinc finger protein 668"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001638">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="zinc finger protein 696"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="11"/>
    </dbReference>
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        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
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        <property type="entry name" value="Znf_AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF49">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07776">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00868">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51915">
        <property type="entry name" value="ZAD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZAD" evidence="14">
        <location>
            <begin position="10"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="209"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="237"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="265"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="293"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="321"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="349"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="377"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="405"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="433"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="461"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="489"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51915"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="JAV83537.1"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="KAB0798072.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="511" mass="56837" checksum="0D2AD1167DEBE50E" modified="2017-08-30" version="1">MELQSLQTEKICRTCLVEDANMRSVFTTESNSIGEETKLYEMLMSCASVQVVEGDGLPGQVCLQCVHYITRAFSFKQLCERSDSTLRDILGKPSLSTYISDFKDDMPIVGSFHTLQMVEEKNDGTDIKPGCIENDLLLPLIDNSENDDNLLDTSILDMDIKADIKETKKKKLKDDTEQPIYACGECTACFTSSIDLKIHGRSHPKTTRHFCKICSQGFASASTLCRHMKVHDGAKRHLCSECGKGFARSDDLTRHLRTHTGEKPFGCKLCGKAFAQSFRLLEHMRAHANEKGFICSVCGKAFSRYTSLAAHNKTHSGIKSHACDVCGKRLCGSGSLAMHMKTHTGLKDHICPYCGKGFTTPSNLIIHKRTHTGERPYICTVCGKGFPDPSRLTVHSRSHSGVKPYVCSVCGRGCVSSSQLKKHMRIHTGEKPYQCNLCPKAFPRSEDLRIHIKTHTGDRSHVCGVCKKGFYQASTLKVHLRIHTGEKPYTCQICDKSFSQTGPLSTHMKTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1MKC4</accession>
    <name>A0A1Y1MKC4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PPYR_11056</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">1611_PpyrPB1</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">1611_PpyrPB1</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Core component of RNA polymerase III (Pol III) which synthesizes small non-coding RNAs using the four ribonucleoside triphosphates as substrates. Can mediate Pol I proofreading of the nascent RNA transcript. Anchors into the Pol III active site to constantly monitor transcription fidelity, cleaves mis-incorporated 5'-ribonucleotides and restarts the transcription process. Once Pol III reaches the poly(dT) termination signal, can induce Pol III clamp opening and transcription termination. Pol III plays an important role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as a nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF-kappa-B through the RIG-I pathway.</text>
    </comment>
    <comment type="function">
        <text evidence="10">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the RNA polymerase III complex consisting of 17 subunits: a ten-subunit horseshoe-shaped catalytic core composed of POLR3A/RPC1, POLR3B/RPC2, POLR1C/RPAC1, POLR1D/RPAC2, POLR3K/RPC10, POLR2E/RPABC1, POLR2F/RPABC2, POLR2H/RPABC3, POLR2K/RPABC4 and POLR2L/RPABC5; a mobile stalk composed of two subunits POLR3H/RPC8 and CRCP/RPC9, protruding from the core and functioning primarily in transcription initiation; and additional subunits homologous to general transcription factors of the RNA polymerase II machinery, POLR3C/RPC3-POLR3F/RPC6-POLR3G/RPC7 heterotrimer required for transcription initiation and POLR3D/RPC4-POLR3E/RPC5 heterodimer involved in both transcription initiation and termination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10 14">Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01028973">
        <property type="protein sequence ID" value="JAV86179.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1MKC4"/>
    <dbReference type="FunCoup" id="A0A1Y1MKC4">
        <property type="interactions" value="525"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1MKC4"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006386">
        <property type="term" value="P:termination of RNA polymerase III transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10509">
        <property type="entry name" value="Zn-ribbon_RPC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000005">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012164">
        <property type="entry name" value="Rpa12/Rpb9/Rpc10/TFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001529">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034014">
        <property type="entry name" value="Zn_ribbon_RPC11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239:SF12">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02150">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005586">
        <property type="entry name" value="RNApol_RpoM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00661">
        <property type="entry name" value="RPOL9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00466">
        <property type="entry name" value="ZF_TFIIS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10 14" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3 11 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10 14" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 12 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS-type" evidence="15">
        <location>
            <begin position="66"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="12">
        <location>
            <begin position="5"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="5"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00054653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR005586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="JAV86179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAB0796995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="109" mass="12892" checksum="1F10E91DA96E938E" modified="2017-08-30" version="1">MMPFCNVCGNLLFVEEAETGKMRLVCRICPLFRNITRTLVNRNYYKLKEIDDVLGGEEAWKNVDSTEETCPKCSHHRAYFMQLQTRSADEPMTTFYRCCNHECSHNWRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1MQJ5</accession>
    <name>A0A1Y1MQJ5_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_01974</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TMEM179 family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01024121">
        <property type="protein sequence ID" value="JAV87954.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01024120">
        <property type="protein sequence ID" value="JAV87955.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0805004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1MQJ5"/>
    <dbReference type="InParanoid" id="A0A1Y1MQJ5"/>
    <dbReference type="OrthoDB" id="8173371at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029673">
        <property type="entry name" value="TMEM179"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059010">
        <property type="entry name" value="TMEM179-179B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31872">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31872:SF4">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26158">
        <property type="entry name" value="Claudin_TMEM179-179B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="204"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="278"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="280"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="309"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="342"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00093776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="JAV87954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0805004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="368" mass="41549" checksum="62BCAD951C57BC3F" modified="2017-08-30" version="1">MDTHSYYLLLDNDTSRVSIAWKGIQLICLLSIGLSGFWAAFCMGRLTLDFGNNCFLYAHLEFLTNDTDLATMRKTYPLLADHLPAASAINLRTTEWGKKSMCYFCQFTPLMSSIYALIWFALFLLCTRGGVGYISDTFSRPWRIVYPALIFGAISAIVMFVSAIHITNGSQEFCTQFVKRWNSTSCFNDIDKYTIYFSGRKATFFANLIASVTSSHICCVSWLLYVLILSLRIMCIADFQMVKVEVMHSTSSKQCLTYTPSSTPQPKQILMATPESISDDVEKQAGKGDRDFTLQDSDKTSLKDEPAHLQSQKQKYSPSLNFADDSPFNEDNKSISLVPLTKKPDDLGSNENRDELAWRAPRIDFSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1MQV9</accession>
    <name>A0A1Y1MQV9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BAG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_13273</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01024020">
        <property type="protein sequence ID" value="JAV88055.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01024019">
        <property type="protein sequence ID" value="JAV88057.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01024018">
        <property type="protein sequence ID" value="JAV88059.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01024016">
        <property type="protein sequence ID" value="JAV88063.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01024015">
        <property type="protein sequence ID" value="JAV88066.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01024013">
        <property type="protein sequence ID" value="JAV88069.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:membrane"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="BAG_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="BAG_domain"/>
    </dbReference>
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        <property type="entry name" value="BCL2-ASSOCIATED ATHANOGENE"/>
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    </dbReference>
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        <property type="entry name" value="STARVIN, ISOFORM E"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="51"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="14"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="JAV88063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0793653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="146" mass="16929" checksum="F8B8566C27FFAAFE" modified="2017-08-30" version="1">MDCRNSHELEENVAVENGSLHTSETDTEKYLKGDNVPNDAPEKQASRETEILKSINTITNGIENLRERIEHFSGCSTDDRDYKYLEEMLLTGLVELDQLDTNDNIMLRQERKRAVQFIQKFMKMLDARLTENKSFLNVNVESDDEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1MZW5</accession>
    <name>A0A1Y1MZW5_PHOPY</name>
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        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PPYR_05134</name>
        <name evidence="11" type="ORF">PPYR_08124</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
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        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
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        <property type="protein sequence ID" value="JAV91203.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KAB0797130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KAB0802948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="269919at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Translation initiation factor eIF2B subunit"/>
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    </dbReference>
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        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45859">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45859:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044122"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00044228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="JAV91203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0797130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAB0802948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="346" mass="38501" checksum="6DDEB708E35FE1E2" modified="2017-08-30" version="1">MLEMELYSDVIKLISDIRHSKLHNSYDIAIHTEKLIEKLISEGKWNSAEDLMTLIKLRITRFANALPQEATSVNIMRHILKIIRDEYDSGFKNKGEGQQSAHHLGSTTMDDCEDYSKVLPSLKSSLLDNLAEYKVELESSADNIAAQALEHIHANEIILTVGKSSTVEKFLKYAAKSRKFQVVVVEAAPRFLGHLMASNLAKNNIETTVIPDSAVFAMMSRVNKVIIGTHTVLANGGLRAESGVHMVALAAKHYSIPIMVLAHMYKLSPMHLCSSEQDAFNICASPADVLPYSSGPLLDKVHVYNPVFDYVPPELVTLFISHQGGNAPSYVYRLLSELYHPDDQEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1N048</accession>
    <name>A0A1Y1N048_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">PPYR_10974</name>
    </gene>
    <organism evidence="23">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="24 25" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">1611_PpyrPB1</strain>
            <tissue evidence="24">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="24">1611_PpyrPB1</strain>
            <tissue evidence="24">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16">Membrane</location>
            <location evidence="16">Coated pit</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LDLR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01017282">
        <property type="protein sequence ID" value="JAV90798.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A1Y1N048">
        <property type="interactions" value="45"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1N048"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005905">
        <property type="term" value="C:clathrin-coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042562">
        <property type="term" value="F:hormone binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006898">
        <property type="term" value="P:receptor-mediated endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
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        <property type="match status" value="34"/>
    </dbReference>
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        <property type="entry name" value="Low-density lipoprotein receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="low-density lipoprotein receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000009">
        <property type="entry name" value="Low-density lipoprotein receptor isoform 1"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="Low-density lipoprotein RecePtor related"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Low-density lipoprotein RecePtor related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000230">
        <property type="entry name" value="Low-density lipoprotein RecePtor related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000132">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000004">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000005">
        <property type="entry name" value="low-density lipoprotein receptor-related protein 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000035">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000040">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000034">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000045">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000078">
        <property type="entry name" value="low-density lipoprotein receptor-related protein 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000108">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000121">
        <property type="entry name" value="low-density lipoprotein receptor-related protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000241">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 6"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000204">
        <property type="entry name" value="Putative low-density lipoprotein receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000062">
        <property type="entry name" value="Terribly reduced optic lobes, isoform AI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000065">
        <property type="entry name" value="Transmembrane protease serine 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="35"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026823">
        <property type="entry name" value="cEGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056588">
        <property type="entry name" value="EGF_LRP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051221">
        <property type="entry name" value="LDLR-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000033">
        <property type="entry name" value="LDLR_classB_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032485">
        <property type="entry name" value="LRP1-like_beta_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22722">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22722:SF14">
        <property type="entry name" value="MEGALIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12662">
        <property type="entry name" value="cEGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16472">
        <property type="entry name" value="DUF5050"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24468">
        <property type="entry name" value="EGF_LRP2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14670">
        <property type="entry name" value="FXa_inhibition"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="33"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00058">
        <property type="entry name" value="Ldl_recept_b"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="24"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="35"/>
    </dbReference>
    <dbReference type="SMART" id="SM00135">
        <property type="entry name" value="LY"/>
        <property type="match status" value="37"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="34"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="4"/>
    </dbReference>
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        <property type="match status" value="4"/>
    </dbReference>
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        <property type="match status" value="17"/>
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    <dbReference type="PROSITE" id="PS50068">
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        <property type="match status" value="35"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51120">
        <property type="entry name" value="LDLRB"/>
        <property type="match status" value="14"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0168">Coated pit</keyword>
    <keyword evidence="12 17" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 17" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-0254">Endocytosis</keyword>
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    <keyword evidence="11 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0675">Receptor</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 21" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="4456"/>
            <end position="4479"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="335"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="19">
        <location>
            <begin position="553"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="19">
        <location>
            <begin position="739"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="19">
        <location>
            <begin position="869"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="1386"/>
            <end position="1425"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="19">
        <location>
            <begin position="1514"/>
            <end position="1556"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="19">
        <location>
            <begin position="1559"/>
            <end position="1602"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="19">
        <location>
            <begin position="2196"/>
            <end position="2239"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="19">
        <location>
            <begin position="2240"/>
            <end position="2281"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="19">
        <location>
            <begin position="2478"/>
            <end position="2518"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="19">
        <location>
            <begin position="2566"/>
            <end position="2607"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="3124"/>
            <end position="3165"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="19">
        <location>
            <begin position="3298"/>
            <end position="3339"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="19">
        <location>
            <begin position="3386"/>
            <end position="3427"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="19">
        <location>
            <begin position="4173"/>
            <end position="4221"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="19">
        <location>
            <begin position="4222"/>
            <end position="4265"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="19">
        <location>
            <begin position="4267"/>
            <end position="4310"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="4407"/>
            <end position="4441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="4555"/>
            <end position="4607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="4555"/>
            <end position="4564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="4572"/>
            <end position="4581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="4587"/>
            <end position="4607"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="44"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="108"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="155"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="195"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="215"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="222"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="234"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="339"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="1026"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="1059"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="1066"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="1078"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="1098"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="1105"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="1158"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="1198"/>
            <end position="1213"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="1263"/>
            <end position="1275"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="1270"/>
            <end position="1288"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="1390"/>
            <end position="1400"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="2701"/>
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        <location>
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            <end position="2807"/>
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    <feature type="disulfide bond" evidence="18">
        <location>
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        <location>
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            <end position="2893"/>
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        <location>
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            <end position="2923"/>
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            <end position="2936"/>
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        <location>
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            <end position="3016"/>
        </location>
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            <end position="3029"/>
        </location>
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            <end position="3071"/>
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            <end position="3113"/>
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            <end position="3602"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00009939"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00037878"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00461"/>
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    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="JAV90798.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KAB0796913.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="4607" mass="514807" checksum="901211915BF1B46C" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1N793</accession>
    <name>A0A1Y1N793_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">PPYR_08101</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="21 22" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">1611_PpyrPB1</strain>
            <tissue evidence="21">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">1611_PpyrPB1</strain>
            <tissue evidence="21">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
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        </reaction>
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        <text evidence="3">Protein modification; protein ubiquitination.</text>
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        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="KAB0797107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:ubiquitin protein ligase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:protein ubiquitination"/>
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        <property type="project" value="UniProtKB-UniPathway"/>
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        <property type="entry name" value="CLUMA_CG014158, isoform A"/>
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        <property type="entry name" value="Putative e3 ubiquitin-protein ligase mib2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Putative E3 ubiquitin-protein ligase MIB2"/>
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        <property type="entry name" value="SH3 Domains"/>
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    </dbReference>
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        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
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        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
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        <property type="entry name" value="Mib_Herc2"/>
    </dbReference>
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        <property type="entry name" value="Mib_Herc2_sf"/>
    </dbReference>
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        <property type="entry name" value="SH3_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
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    </dbReference>
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        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
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        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
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        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MIB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24202:SF4">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MIB2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159034">
        <property type="entry name" value="Mib/herc2 domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51416">
        <property type="entry name" value="MIB_HERC2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01357">
        <property type="entry name" value="ZF_ZZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50135">
        <property type="entry name" value="ZF_ZZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13 14" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0914">Notch signaling pathway</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MIB/HERC2" evidence="19">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="ZZ-type" evidence="18">
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    <dbReference type="InterPro" id="IPR013918">
        <property type="entry name" value="Nucleotide_exch_fac_Fes1"/>
    </dbReference>
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        <property type="entry name" value="HSP70-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19316">
        <property type="entry name" value="PROTEIN FOLDING REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nucleotide exchange factor Fes1" evidence="3">
        <location>
            <begin position="37"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="JAV92197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0791154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="341" mass="37826" checksum="4EA1D75A3096B46B" modified="2017-08-30" version="1">MSENNEIAGAITYPKGKNVENGSDAAPISQPRQPTDLQGLLRFAMEATKAEDAPNESSVGPIDEERKKFLENALASMSVDVIEILQTNIKILQNCDVLTESGDIAQHVLALETILDYIDNTDVANDFHKIGGFSIFNPCLKCVKSEIRAGACDVIAELCQNNPYCQRMVLDAALIPTLVKILATDSSNTVCVKALYAISCVIRQYTEGFHQFVQYEGLSVLLKTLQKNDDKLTTKTTFLLSSLCGTQPDLMSRLVFLEYVPLLISLLNNVRKPSHEHILSLLLLLATENHSAMMCCKDPKYKLQGILENHIKIVAGKEEYQEEESYCRQLLRLLFPAANGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1NA95</accession>
    <name>A0A1Y1NA95_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">sphinganine-1-phosphate aldolase</fullName>
            <ecNumber evidence="14">4.1.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Sphingosine-1-phosphate aldolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PPYR_06332</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="19 20" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">1611_PpyrPB1</strain>
            <tissue evidence="19">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">1611_PpyrPB1</strain>
            <tissue evidence="19">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 16 17">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the group II decarboxylase family. Sphingosine-1-phosphate lyase subfamily.</text>
    </comment>
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    <dbReference type="EMBL" id="GEZM01012147">
        <property type="protein sequence ID" value="JAV93144.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01012146">
        <property type="protein sequence ID" value="JAV93146.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KAB0800592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1NA95"/>
    <dbReference type="FunCoup" id="A0A1Y1NA95">
        <property type="interactions" value="1299"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1NA95"/>
    <dbReference type="OrthoDB" id="10254570at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
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    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008117">
        <property type="term" value="F:sphinganine-1-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030149">
        <property type="term" value="P:sphingolipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Sphingosine phosphate lyase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000020">
        <property type="entry name" value="sphingosine-1-phosphate lyase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.140.2150:FF:000001">
        <property type="entry name" value="Sphingosine-1-phosphate lyase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050477">
        <property type="entry name" value="GrpII_AminoAcid_Decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42735">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42735:SF6">
        <property type="entry name" value="SPHINGOSINE-1-PHOSPHATE LYASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 17" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 16 17" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="16">
        <location>
            <position position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00042568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="JAV93146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAB0800592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="548" mass="61261" checksum="B6B56C5512BE51E2" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1ND50</accession>
    <name>A0A1Y1ND50_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pre-mRNA processing factor 4 (PRP4)-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PPYR_15729</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01007001">
        <property type="protein sequence ID" value="JAV95488.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01002117">
        <property type="protein sequence ID" value="KAB0789983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1ND50"/>
    <dbReference type="FunCoup" id="A0A1Y1ND50">
        <property type="interactions" value="1450"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1ND50"/>
    <dbReference type="OrthoDB" id="540662at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030621">
        <property type="term" value="F:U4 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000411">
        <property type="entry name" value="U4/U6 small nuclear ribonucleoprotein Prp4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001300">
        <property type="entry name" value="U4/U6 small nuclear ribonucleoprotein Prp4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.110">
        <property type="entry name" value="Pre-mRNA processing factor 4 domain"/>
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    </dbReference>
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        <location>
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        <location>
            <begin position="472"/>
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        </location>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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        <source>
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        <source>
            <dbReference type="SMART" id="SM00500"/>
        </source>
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        <source>
            <dbReference type="EMBL" id="JAV95488.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAB0789983.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
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    <sequence length="512" mass="58037" checksum="1FCD672B8AF0534E" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1NGJ6</accession>
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            <fullName evidence="1">Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1</fullName>
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        <name evidence="4" type="ORF">PPYR_08699</name>
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    <organism evidence="3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">S-adenosyl-L-methionine-dependent methyltransferase that mediates RNA cap1 2'-O-ribose methylation to the 5'-cap structure of RNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA to produce m(7)GpppNmp (cap1).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleoside) in mRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67020"/>
            <dbReference type="Rhea" id="RHEA-COMP:17167"/>
            <dbReference type="Rhea" id="RHEA-COMP:17168"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:167609"/>
            <dbReference type="EC" id="2.1.1.57"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.1.1.57" evidence="1"/>
    <dbReference type="EMBL" id="GEZM01003045">
        <property type="protein sequence ID" value="JAV96961.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KAB0797706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004483">
        <property type="term" value="F:methyltransferase cap1 activity"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006370">
        <property type="term" value="P:7-methylguanosine mRNA capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016556">
        <property type="term" value="P:mRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="FtsJ-like methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
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    </dbReference>
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        <property type="entry name" value="mRNA_Cap_2O-Ribose_MeTrfase"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16121:SF0">
        <property type="entry name" value="CAP-SPECIFIC MRNA (NUCLEOSIDE-2'-O-)-METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CAP-SPECIFIC MRNA (NUCLEOSIDE-2'-O-)-METHYLTRANSFERASE 1-RELATED"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-0808">Transferase</keyword>
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        <location>
            <begin position="93"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU368012"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="JAV96961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0797706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="661" mass="76490" checksum="B91868272F368433" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1NGV6</accession>
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            <fullName evidence="7 11">Triosephosphate isomerase</fullName>
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        </recommendedName>
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        <name evidence="13" type="ORF">PPYR_07815</name>
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    <organism evidence="12">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:18585"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="5.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the triosephosphate isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.1" evidence="6 11"/>
    <dbReference type="EMBL" id="GEZM01002999">
        <property type="protein sequence ID" value="JAV96999.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1NGV6"/>
    <dbReference type="FunCoup" id="A0A1Y1NGV6">
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    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1NGV6"/>
    <dbReference type="OrthoDB" id="6715177at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00189"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004807">
        <property type="term" value="F:triose-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046166">
        <property type="term" value="P:glyceraldehyde-3-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00311">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000025">
        <property type="entry name" value="Triosephosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00147_B">
        <property type="entry name" value="TIM_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035990">
        <property type="entry name" value="TIM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022896">
        <property type="entry name" value="TrioseP_Isoase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000652">
        <property type="entry name" value="Triosephosphate_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020861">
        <property type="entry name" value="Triosephosphate_isomerase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00419">
        <property type="entry name" value="tim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139">
        <property type="entry name" value="TRIOSEPHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139:SF2">
        <property type="entry name" value="TRIOSEPHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00121">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51351">
        <property type="entry name" value="Triosephosphate isomerase (TIM)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00171">
        <property type="entry name" value="TIM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51440">
        <property type="entry name" value="TIM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="9 11" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="10 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00019397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="JAV96999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAB0799935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="247" mass="26570" checksum="0C6B35AC6ECF15B1" modified="2017-08-30" version="1">MGRKFVVGGNWKMNGDKKQISEIIEFLKAGPLHPDTQVIVGVPAIYLEHVKQSVPSNVEVAAQNCYKIPKGAFTGEISPAMIKDIGVNWVILGHSERRNVFGESDELVAEKVAHALDSGLKVIACIGEKLEEREAGQTEAVVFRQTKAIADKIKDWSHVVIAYEPVWAIGTGKTATPAQAQEVHKALRGWLSSNVSAQVGETVSIQYGGSVTAANCKELASQPDIDGFLVGGASLKPEFVNIVNAKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1NM78</accession>
    <name>A0A1Y1NM78_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Arrestin C-terminal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_05874</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arrestin family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01000907">
        <property type="protein sequence ID" value="JAV98250.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000003">
        <property type="protein sequence ID" value="KAB0801520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1NM78"/>
    <dbReference type="FunCoup" id="A0A1Y1NM78">
        <property type="interactions" value="610"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1NM78"/>
    <dbReference type="OrthoDB" id="2333384at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF176">
        <property type="entry name" value="ARRESTIN DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0716">Sensory transduction</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="3">
        <location>
            <begin position="177"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="JAV98250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0801520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="403" mass="45242" checksum="741F8A5A4032C4FE" modified="2017-08-30" version="1">MGLKSCEIILENNWGTYYVGQTVTGRVEFDLDSPKKVRGVSILFKGDSNTNWFVEESRTNNDGKQENERIELNGYEEYFKIEYYLIGGQGDEVDIPPGHHSYPFTCVLPPSLPSSFEGDYGYVRYIIKVTFDRPWKFDHETKKAFTVLSPLDLNSNPRLKEPTRLALEKYFCCFCCKSGPLTCIISIPRTGYVSGQTIPVVLDVDNISNIEITNVQVSLRKIVTYHTQTPRRESKKDVKVIAEIKVGSTTPHGSNTYNQPIVIPPIPPSNLTNCNLIDLDYELYVELNISGFHTNLTGKIPITIGTTPLGPSSSAPTPISTKINIEPEDFTDLTPSNDNDSKAPTMGWVNNGNIYPALPTFAESQFGTSSIREKGDNEYVMYADNRQHYSPMYPVYSYTDAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N3ZY64</accession>
    <name>A0A5N3ZY64_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_15704</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01002084">
        <property type="protein sequence ID" value="KAB0790005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N3ZY64"/>
    <dbReference type="InParanoid" id="A0A5N3ZY64"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09077">
        <property type="entry name" value="R1-I-EN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33273">
        <property type="entry name" value="DOMAIN-CONTAINING PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33273:SF2">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="82"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0790005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="177" mass="19166" checksum="5C1D8F3AD9E83BA5" modified="2020-02-26" version="1" fragment="single">MLRVIQVNLHNMGEALDLAVQKAQETRRDLLVLAEYGSARASGGMFVDLSGKAAIMCVNASIGADRVGEGRGFVWIQTQGVYVYSVYFPPNESDFELEGKLNDIADSIKRIGATKVIIAGDINAASPAWGARSSNNRGEIIMEWLETLNLVVVNTGSKPTFEQGTRQSIVDVTLCSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N3ZYE1</accession>
    <name>A0A5N3ZYE1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_15597</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01001957">
        <property type="protein sequence ID" value="KAB0790085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N3ZYE1"/>
    <dbReference type="InParanoid" id="A0A5N3ZYE1"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47501:SF5">
        <property type="entry name" value="HAT C-TERMINAL DIMERISATION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47501">
        <property type="entry name" value="TRANSPOSASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0790085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="542" mass="61736" checksum="D2E856731F93AFCB" modified="2020-02-26" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N3ZYQ6</accession>
    <name>A0A5N3ZYQ6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MULE transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_15465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01001683">
        <property type="protein sequence ID" value="KAB0790206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N3ZYQ6"/>
    <dbReference type="InParanoid" id="A0A5N3ZYQ6"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018289">
        <property type="entry name" value="MULE_transposase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10551">
        <property type="entry name" value="MULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MULE transposase" evidence="1">
        <location>
            <begin position="93"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0790206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="376" mass="43237" checksum="72BCA08542583D43" modified="2020-02-26" version="1">MNGYAEPWGSAEHTLRTAALKKVIRRKRNEMNIAPPNPATVQELVFPDEYRSYGLPNGEQELFLLADTGPIQNRIVIFGRERSLRILSESDKWYVDGTFKSTPPLFHQVYVILPERFGGVIALLYALLPNKLQITYATMIDLIQNINPQLAFNPTYISCDYELSAINAFKNAFPGVTMHGCFFHLTKNLKKHLSILGLLHRYNTDAEFAVMARMVSSLAFVPINDLDEAVDALGEALPVELQPLLQWLEDNYIGRPNRRGNGRRLAMFSPNMWSVFDRVQNNQDRTNNHAEAAHRRLQIELGMDHPTIWKFVNALKSIQKGRDGEYEQLLAGRQPPKKLKKYRDADTRITRLVLDFENRNIIEYLRGISYNYEMNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N3ZZM4</accession>
    <name>A0A5N3ZZM4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_15084</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01001174">
        <property type="protein sequence ID" value="KAB0790513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N3ZZM4"/>
    <dbReference type="InParanoid" id="A0A5N3ZZM4"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF220">
        <property type="entry name" value="PROTEIN ALP1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="8">
        <location>
            <begin position="39"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0790513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="272" mass="31064" checksum="59EDED3307502A4B" modified="2020-02-26" version="1" fragment="single">VITERLLNEMLPKPTTEMWKSIANDFFTLWNFPNCLGALDGKHIIIQAPPNSGSLFFNYKKTFSVVLLALVDAHYNFIAVDVGAYGKNSDGGIFSSSNLGKALQRGTLSVPRNSTLPDTTTDAPHVIVGDEAFPLKSYLMRPYPGHDLDLQKRILNYRLCRVRRIVENTFGILCQKFRIYNRRLQSKPENVDNIILSTCILHNFIKKFGANTYIYQTINANSNETREEIRLDNLPMQGGNATQDAFRVRELFKEYFNSEIGSVPWQEERITF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N3ZZW3</accession>
    <name>A0A5N3ZZW3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_14990</name>
        <name evidence="1" type="ORF">PPYR_15541</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01001859">
        <property type="protein sequence ID" value="KAB0790136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01001033">
        <property type="protein sequence ID" value="KAB0790603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N3ZZW3"/>
    <dbReference type="InParanoid" id="A0A5N3ZZW3"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0790136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0790603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="177" mass="19672" checksum="73FEF213C47752CB" modified="2020-02-26" version="1" fragment="single">VHGKMGLRFGISRKELLEIVGQYIAKNKISTPFKNNVPSGDWFLEFKKRHNLSIKKPEIVKYARKKNTDPFVISEYFQLLEKTLNDLKLIDAPAKIWNMDETSFCTDPSRTKVVGVKGVSSTRITAGSGRNNTTVLFAASASGEKAPPLIVYKGKNVWDTWIAEDGKGYPGTAYAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A068</accession>
    <name>A0A5N4A068_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_14839</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000868">
        <property type="protein sequence ID" value="KAB0790711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A068"/>
    <dbReference type="InParanoid" id="A0A5N4A068"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="1">
        <location>
            <begin position="72"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0790711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="182" mass="20815" checksum="77F6D359406A38A0" modified="2020-02-26" version="1" fragment="single">ILSRFPLKDSIFSKLDFMDPETVVNRKVKSIADVVSHFSNLHSHSLQDIDSQWRMLRNINFDDFNLCIGDDIVSFWRKVSKIKLGTGEQKFGKLIAFVFNLLSLPHSSANVERCFSQINLNKTNMRNRLISSTLEGILLTKSLVSEGGQCDKFEINKEMCKKMNSTDLYKNKENEGSDLDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A181</accession>
    <name>A0A5N4A181_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Peptidase M12B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PPYR_02883</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">1611_PpyrPB1</strain>
            <tissue evidence="19">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="14">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A5N4A181">
        <property type="interactions" value="74"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A181"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04273">
        <property type="entry name" value="ZnMc_ADAMTS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000006">
        <property type="entry name" value="A disintegrin and metalloproteinase with thrombospondin motifs 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000005">
        <property type="entry name" value="ADAM metallopeptidase with thrombospondin type 1 motif 9"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.830">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1620.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013273">
        <property type="entry name" value="ADAMTS/ADAMTS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050439">
        <property type="entry name" value="ADAMTS_ADAMTS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041645">
        <property type="entry name" value="ADAMTS_CR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045371">
        <property type="entry name" value="ADAMTS_CR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010294">
        <property type="entry name" value="ADAMTS_spacer1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012314">
        <property type="entry name" value="Pept_M12B_GON-ADAMTSs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002870">
        <property type="entry name" value="Peptidase_M12B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723:SF278">
        <property type="entry name" value="ADAM METALLOPEPTIDASE WITH THROMBOSPONDIN TYPE 1 MOTIF A, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723">
        <property type="entry name" value="ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17771">
        <property type="entry name" value="ADAMTS_CR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19236">
        <property type="entry name" value="ADAMTS_CR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05986">
        <property type="entry name" value="ADAMTS_spacer1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08685">
        <property type="entry name" value="GON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01562">
        <property type="entry name" value="Pep_M12B_propep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01421">
        <property type="entry name" value="Reprolysin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19030">
        <property type="entry name" value="TSP1_ADAMTS"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01857">
        <property type="entry name" value="ADAMTSFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51046">
        <property type="entry name" value="GON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="14" id="KW-0106">Calcium</keyword>
    <keyword evidence="11 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 14 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="9 14 16" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M12B" evidence="17">
        <location>
            <begin position="207"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="GON" evidence="18">
        <location>
            <begin position="1446"/>
            <end position="1643"/>
        </location>
    </feature>
    <feature type="active site" evidence="13 16">
        <location>
            <position position="350"/>
        </location>
    </feature>
    <feature type="binding site" description="in inhibited form" evidence="14">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14 16">
        <location>
            <position position="349"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14 16">
        <location>
            <position position="353"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14 16">
        <location>
            <position position="359"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="409"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="412"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="412"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="281"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="307"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="327"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="365"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="438"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="449"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="456"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="482"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="517"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="521"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="532"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="19">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR613273-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR613273-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR613273-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAB0791083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="21">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1643" mass="186691" checksum="000727AB970C2B47" modified="2020-02-26" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A190</accession>
    <name>A0A5N4A190_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PPYR_02894</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A190"/>
    <dbReference type="InParanoid" id="A0A5N4A190"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000218">
        <property type="entry name" value="facilitated trehalose transporter Tret1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050549">
        <property type="entry name" value="MFS_Trehalose_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021:SF46">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="255"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="293"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="321"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="354"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="393"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="421"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="19"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0791094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="465" mass="51192" checksum="94A88CC963340A5A" modified="2020-02-26" version="1">MERVIPKSGRTKIFVQIYAIMAVSVGSFSTGAQFAWPSPSVPQLLLNTSYIGRITMEQASYFSILPPIVVIISSFFIGNAMRFIGREYIMGFLAVPHVVHWIVIANATNLITVYVARAISGVSDAICYSTIAVYVGEITTPHVRGTWGNSMMCAILLGHLSVAAVGAYQDIVTTAYIFTVPPLLYALLIIFIPESPYFLIMTGRNEEAKIALQWLRWQQNVDDEYLVLVKNVQEQVMAPGQFGDLFRDAVNRKALLVNVGLRICQQFSGFSAFVIYVQIIFELATDKSVSAEMSTVIVYSVLFLLSVLATSAITRCGRRTMLTISSVGCSGSLLANAVYFYIADETGANLSQLGWLPLLFMASYMAFLATGLSPLPSLMTGELFATSIKSHAMFVSTIARGVALIIAPKILQLLIGHLPMYFSFTFFTLSCLASAIFCYRCVPETKGKTLQEIQDILRKKSFCQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A3E9</accession>
    <name>A0A5N4A3E9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">[histone H3]-lysine(4) N-trimethyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.354</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PPYR_03608</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">1611_PpyrPB1</strain>
            <tissue evidence="19">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60260"/>
            <dbReference type="Rhea" id="RHEA-COMP:15537"/>
            <dbReference type="Rhea" id="RHEA-COMP:15547"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.354"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60272"/>
            <dbReference type="Rhea" id="RHEA-COMP:15537"/>
            <dbReference type="Rhea" id="RHEA-COMP:15540"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60268"/>
            <dbReference type="Rhea" id="RHEA-COMP:15540"/>
            <dbReference type="Rhea" id="RHEA-COMP:15543"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61929"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.354" evidence="2"/>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A5N4A3E9">
        <property type="interactions" value="771"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A3E9"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140999">
        <property type="term" value="F:histone H3K4 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12304">
        <property type="entry name" value="RRM_Set1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19169">
        <property type="entry name" value="SET_SETD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.270.10:FF:000010">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024657">
        <property type="entry name" value="COMPASS_Set1_N-SET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044570">
        <property type="entry name" value="Set1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037841">
        <property type="entry name" value="SET_SETD1A/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45814">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45814:SF2">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11764">
        <property type="entry name" value="N-SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01291">
        <property type="entry name" value="N-SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00508">
        <property type="entry name" value="PostSET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RRM" evidence="16">
        <location>
            <begin position="91"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="17">
        <location>
            <begin position="1284"/>
            <end position="1401"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="18">
        <location>
            <begin position="1407"/>
            <end position="1423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="188"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="331"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="415"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="534"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="722"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="781"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="188"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="338"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="351"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="383"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="467"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="547"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="722"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="789"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="820"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="933"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="959"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1011"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1027"/>
            <end position="1042"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAB0791808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1423" mass="161998" checksum="6A6283CC5A9CA8FF" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A422</accession>
    <name>A0A5N4A422_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_13980</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A422"/>
    <dbReference type="FunCoup" id="A0A5N4A422">
        <property type="interactions" value="40"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A422"/>
    <dbReference type="OrthoDB" id="9448935at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000116">
        <property type="entry name" value="Serine protease P16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252">
        <property type="entry name" value="ACROSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252:SF7">
        <property type="entry name" value="HYALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024383538" description="Peptidase S1 domain-containing protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="3">
        <location>
            <begin position="37"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0792019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="286" mass="31018" checksum="4D5C17A2148A193A" modified="2020-02-26" version="1">MELVFLVLVVFPAGLAAIHNFADVACGRRSERRTAKVVGGEDAAEGEFPWLVSLTRRGAHFCGGSLITDRHVLSAGHCLCSGSSEIPAGQIRVTLGQHVLSEESAEKFEVAVKSSTLHPDYTCGKVKNDLAILELERQVKWSDVVHPACLPAGLQEDGHNRFVDVLATVAGWGWTNENNNLGSRGDRLQKAKVNILEREQCQRWFKSQGKKTKIQETQICAGYEQGGIDSCWADSGGPLMTTSDSGEKIIVVGVVSTGIGCARPSLPGIYTRVSDYIPWIRSVVKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A4U2</accession>
    <name>A0A5N4A4U2_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">3-hydroxyacyl-CoA dehydrogenase type-2</fullName>
            <ecNumber evidence="3">1.1.1.53</ecNumber>
            <ecNumber evidence="4">1.1.1.62</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">3-hydroxyacyl-CoA dehydrogenase type II</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Mitochondrial ribonuclease P protein 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Type II HADH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">PPYR_14299</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">1611_PpyrPB1</strain>
            <tissue evidence="21">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(3S)-3-hydroxybutanoyl-CoA + NAD(+) = acetoacetyl-CoA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:30799"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57286"/>
            <dbReference type="ChEBI" id="CHEBI:57316"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:30800"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="10">
            <dbReference type="Rhea" id="RHEA:30801"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>11-dehydrocorticosterone + NAD(+) = pregn-4-ene-3,11,20,21-tetraone + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42020"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78600"/>
            <dbReference type="ChEBI" id="CHEBI:78601"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:42021"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>17beta-estradiol + NAD(+) = estrone + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24612"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16469"/>
            <dbReference type="ChEBI" id="CHEBI:17263"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.62"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:24613"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>17beta-hydroxy-5alpha-androstan-3-one + NAD(+) = 5alpha-androstan-3,17-dione + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15994"/>
            <dbReference type="ChEBI" id="CHEBI:16330"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:41993"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>3beta,7beta-dihydroxy-5beta-cholan-24-oate + NAD(+) = 3beta-hydroxy-7-oxo-5beta-cholan-24-oate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42024"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78602"/>
            <dbReference type="ChEBI" id="CHEBI:78603"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:42025"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>5alpha-androstane-3alpha,17beta-diol + NAD(+) = 17beta-hydroxy-5alpha-androstan-3-one + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42004"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16330"/>
            <dbReference type="ChEBI" id="CHEBI:36713"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.53"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="7">
            <dbReference type="Rhea" id="RHEA:42006"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>5alpha-pregnan-20beta-ol-3-one + NAD(+) = 5alpha-pregnane-3,20-dione + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42008"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28952"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78594"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:42009"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57318"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="1.1.1.35"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:22433"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="6">
            <dbReference type="Rhea" id="RHEA:22434"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>cortisol + NAD(+) = 11beta,17alpha-dihydroxypregn-4-ene-3,20,21-trione + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42012"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17650"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78595"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:42013"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>cortisone + NAD(+) = 17alpha-hydroxypregn-4-en-3,11,20-trione-21-al + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42016"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16962"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78596"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:42017"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ursodeoxycholate + NAD(+) = 7-oxolithocholate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42028"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78604"/>
            <dbReference type="ChEBI" id="CHEBI:78605"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:42029"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 20">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.53" evidence="3"/>
    <dbReference type="EC" id="1.1.1.62" evidence="4"/>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A4U2"/>
    <dbReference type="FunCoup" id="A0A5N4A4U2">
        <property type="interactions" value="596"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A4U2"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003857">
        <property type="term" value="F:(3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047044">
        <property type="term" value="F:androstan-3-alpha,17-beta-diol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004303">
        <property type="term" value="F:estradiol 17-beta-dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008209">
        <property type="term" value="P:androgen metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008210">
        <property type="term" value="P:estrogen metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05371">
        <property type="entry name" value="HSD10-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000215">
        <property type="entry name" value="3-hydroxyacyl-CoA dehydrogenase type-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43658:SF8">
        <property type="entry name" value="17-BETA-HYDROXYSTEROID DEHYDROGENASE 14-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43658">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00050141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00050365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00050435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00050927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00051637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00051831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00052095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00052417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00052668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00072938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00079624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00082293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00082399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAB0792340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="255" mass="27179" checksum="AC37BD9266D8DDC7" modified="2020-02-26" version="1">MFGTVSLVTGGASGLGRATVERFVKQGGKVVLCDLPVTKGSELAKELGEDTCIYAPVNVTKESEVQSALQIAKEKFGRLDNVVNCAGIGVAFKTYNFKKKQAHNLDDFSRVLQVNAIGTFNVIRLAVSLIDENPPDENGQRGVIVNTASIAAYEGQMGQAAYSASKGAIVGMTLPIARDLASQGIRVCTIAPGLFKTPLLGDLPEKVTTFLAKSIPFPQRLGDPDEFAKLAQSIIENPMLNGEVIRLDGALRMQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A4W6</accession>
    <name>A0A5N4A4W6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_14311</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A4W6"/>
    <dbReference type="FunCoup" id="A0A5N4A4W6">
        <property type="interactions" value="20"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A4W6"/>
    <dbReference type="OrthoDB" id="6415662at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000437">
        <property type="entry name" value="Beat-IIIc, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21261">
        <property type="entry name" value="BEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21261:SF14">
        <property type="entry name" value="BEATEN PATH IV, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024396821" description="Ig-like domain-containing protein" evidence="5">
        <location>
            <begin position="21"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="37"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0792352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="283" mass="32013" checksum="0B20F72250B8BFED" modified="2020-02-26" version="1">MRFLLVQIFYYVLVTEYIQATGLKWVRVNVPQYRSPGESAQLLCDYDLGNDTLYSIKWYKDHEEFYRFVPMARPQATSYKMEGIFVDMGLSDRKKVVLRTVNLKSSGLYRCEVSAEAPSFSSAQSEARMEVVYLPKEDPVITGVELQYQIGDEINLNCTSGKSHPAPVLHWYINEQQVASPEALIYYPQVQHRHGLMSVTLGLKFSLSSRHFLGGSMRVKCVASVSPVLWKGDSESVVESLAVKDMREALLLVRSSGYKVETLPGIFLILIPALLLCARLNLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A5E0</accession>
    <name>A0A5N4A5E0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Odorant receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PPYR_14438</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cell membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A5E0"/>
    <dbReference type="FunCoup" id="A0A5N4A5E0">
        <property type="interactions" value="48"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A5E0"/>
    <dbReference type="OrthoDB" id="8117390at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="195"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="272"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU351113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0792479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="401" mass="45946" checksum="AB85D932F519095C" modified="2020-02-26" version="1">MSDIQVVNTEKLPKHIWHDGVKWLFVPIKIILDSLSVWAERQNKFTLILSIIVVTSYIYILTGQISFIFDKETDLTTAADGIAGLIVVLETISRRVISTILAKKIARILSTIYHQFWPSDMVGDEVDRLLRRRSWIVLVSVGIYTISALFWASQCLTVPFQVHATPLPSKFTFPYLQSPFYEMVYVWQGALSAELAVNICAFDLFFVSLIWTCVAQFRLLREYLKRNFARVARSGFNRTEDNTEAWNVVLKCIKHHHLLIETAKNLENMLTVFILMLYIGTIGTVCLSGFLLTIVRTEIGRPLTYFCGHMGQIFMYCFIGNELILESMAFSDTVYECGWHLGAYERRVQKSLVLIMARAQRPITITLGGFGVLSLSSYMKLLKFCFSVYTLLNSMMAKQRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A5I4</accession>
    <name>A0A5N4A5I4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nocturnin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PPYR_14542</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CCR4/nocturin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A5I4"/>
    <dbReference type="FunCoup" id="A0A5N4A5I4">
        <property type="interactions" value="119"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A5I4"/>
    <dbReference type="OrthoDB" id="276515at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048511">
        <property type="term" value="P:rhythmic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000012">
        <property type="entry name" value="nocturnin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050410">
        <property type="entry name" value="CCR4/nocturin_mRNA_transcr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121">
        <property type="entry name" value="CARBON CATABOLITE REPRESSOR PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121:SF45">
        <property type="entry name" value="NOCTURNIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0090">Biological rhythms</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="10">
        <location>
            <begin position="154"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0792583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="436" mass="49689" checksum="5070A2A5F4B1EF87" modified="2020-02-26" version="1">MEDLGENGTADLQGSLHLAEALAKVSLWTSSAAKRRIAARSAELKYGQVDEESGAYVPPKQLLMYLVRMGSFSSAPKILNDDNQDRDVRLPDTISRVELLKHCQNYLQLHPMIKRNFRLSPVYETDYSANFHKLNSVSKAYSDYVSGAYNVRILQWNILSQALGVMNDNFARCPDSALDWNFRRYRIVEEIVQYCPDVICLQEVDHFNFLKHVLGTQGYEGMFFPKPDSPCFYIEGNNGPDGCAIFYRKNKFDLVKNENKVLEIWRIQSNQVAVMAVLRIRETGQEVCVVTTHLKAREGALLSTLRNEQGKDLLQFIGYNCGNRPIILCGDFNAEPTEPVYETILNSMDFSSAYASCNVADLRSADREPPYTTWKIREEGEVCHTIDYIFYSRDAMEVEAVLDFPSGEDIGQDRVPSYLYPSDHFSLVCDFRLTNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A653</accession>
    <name>A0A5N4A653_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">WD repeat-containing protein 75 second beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_14773</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A653"/>
    <dbReference type="FunCoup" id="A0A5N4A653">
        <property type="interactions" value="936"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A653"/>
    <dbReference type="OrthoDB" id="4096at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000234">
        <property type="term" value="P:positive regulation of rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057644">
        <property type="entry name" value="Beta-prop_WDR75_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053826">
        <property type="entry name" value="WDR75"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44215">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44215:SF1">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23869">
        <property type="entry name" value="Beta-prop_WDR75_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23769">
        <property type="entry name" value="Beta-prop_WDR75_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="WD repeat-containing protein 75 second beta-propeller" evidence="8">
        <location>
            <begin position="333"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF23769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0792814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="738" mass="83326" checksum="0A2146DE1B291480" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A667</accession>
    <name>A0A5N4A667_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosducin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_14776</name>
        <name evidence="4" type="ORF">PPYR_14780</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosducin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A667"/>
    <dbReference type="FunCoup" id="A0A5N4A667">
        <property type="interactions" value="1608"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A667"/>
    <dbReference type="OrthoDB" id="45518at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02988">
        <property type="entry name" value="Phd_like_VIAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051498">
        <property type="entry name" value="Phosducin-like_chap/apop_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024253">
        <property type="entry name" value="Phosducin_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45809">
        <property type="entry name" value="VIRAL IAP-ASSOCIATED FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45809:SF3">
        <property type="entry name" value="VIRAL IAP-ASSOCIATED FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02114">
        <property type="entry name" value="Phosducin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosducin" evidence="2">
        <location>
            <begin position="42"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0792817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0792821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="232" mass="26452" checksum="D3A03DAA3B5D797C" modified="2020-02-26" version="1">MQNPNDDTEWNDVLRAKGIIPPKEKEVTEDDLVNMLEQTIKEKQATGDGKHITDMNLDELDELEDSEDEGILLEYRQKRIAEMKALADRSKFGSVLEISAQDYVQEINKAGEGIWVVLHLYKQGIPLCALINQFMHNLAAKFRTVKFVKSISTTCIPNYPDKNLPTIFIYFEGEMKKQLVGPVELRGPNMTQDEFEYMIGKAGAVPTDLTEDPRVAVKDKLFSDLKDLNNDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A707</accession>
    <name>A0A5N4A707_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Frizzled-4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PPYR_12715</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">1611_PpyrPB1</strain>
            <tissue evidence="20">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor Fz/Smo family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A707"/>
    <dbReference type="FunCoup" id="A0A5N4A707">
        <property type="interactions" value="258"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A707"/>
    <dbReference type="OrthoDB" id="5959102at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042813">
        <property type="term" value="F:Wnt receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017147">
        <property type="term" value="F:Wnt-protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035567">
        <property type="term" value="P:non-canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07448">
        <property type="entry name" value="CRD_FZ4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.2000.10:FF:000008">
        <property type="entry name" value="Frizzled receptor 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2000.10">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015526">
        <property type="entry name" value="Frizzled/SFRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000539">
        <property type="entry name" value="Frizzled/Smoothened_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020067">
        <property type="entry name" value="Frizzled_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036790">
        <property type="entry name" value="Frizzled_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041765">
        <property type="entry name" value="FZ4_CRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11309">
        <property type="entry name" value="FRIZZLED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11309:SF23">
        <property type="entry name" value="FRIZZLED-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01534">
        <property type="entry name" value="Frizzled"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01392">
        <property type="entry name" value="Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00489">
        <property type="entry name" value="FRIZZLED"/>
    </dbReference>
    <dbReference type="SMART" id="SM00063">
        <property type="entry name" value="FRI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01330">
        <property type="entry name" value="Frizzled"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63501">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50038">
        <property type="entry name" value="FZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="11 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 17" id="KW-0732">Signal</keyword>
    <keyword evidence="14" id="KW-0807">Transducer</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024287400" description="Frizzled-4" evidence="17">
        <location>
            <begin position="17"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="275"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="359"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="406"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="442"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="FZ" evidence="18">
        <location>
            <begin position="23"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="19">
        <location>
            <begin position="221"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="23"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="31"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="68"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="95"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="99"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAB0793095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="543" mass="60718" checksum="FF90DBD0684F43EF" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A726</accession>
    <name>A0A5N4A726_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PPYR_12741</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A726"/>
    <dbReference type="FunCoup" id="A0A5N4A726">
        <property type="interactions" value="25"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A726"/>
    <dbReference type="OrthoDB" id="5597713at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000068">
        <property type="entry name" value="transmembrane protease serine 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000036">
        <property type="entry name" value="Trypsin beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050430">
        <property type="entry name" value="Peptidase_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276:SF91">
        <property type="entry name" value="AT26814P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276">
        <property type="entry name" value="POLYSERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0720">Serine protease</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024384351" description="Peptidase S1 domain-containing protein" evidence="8">
        <location>
            <begin position="16"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="9">
        <location>
            <begin position="32"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0793121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="262" mass="27826" checksum="1B875D318538B22C" modified="2020-02-26" version="1">MKHLLVVLLAGLTTAFRFTPAVVFKDVERPKIINGSPAVAGQFPWQVSNRFKTLYGTSFCGGSLISNSWVLTAAHCVQNAYSFEIGLGSLSSKSNSLMVVTDEGFPHEAYDPYSLNNDIGLINLKRTVEFTDTIRAIRLGKDYVADHTGLTVSGWGKTSDASTSVSAALNFVELTTIPNKVCGNIYSSAVTDDVVCCTGENSKSTCNGDSGGPLIHLDANGTATHVGVVSFGHIAGCAKGYPAGFSRTSRYGSWIKSHTGIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A9K4</accession>
    <name>A0A5N4A9K4_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_13621</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0794001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A9K4"/>
    <dbReference type="InParanoid" id="A0A5N4A9K4"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024412974" evidence="2">
        <location>
            <begin position="19"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0794001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="212" mass="22472" checksum="F6F79CF9C8AA7312" modified="2020-02-26" version="1">MIFPLLAVSFLLLPYTIAYPQADIPNLKANERDGSDFGPPAGKPKPGDNGDGSDFRPPSGKPKPEGGGDGSDFGPPGGKPKPGGNGDGSDFGPPRPSAIDQGFDGTLLGGFPDYDQGFDGSQYGPPRPNSNWGFVPPQYRPGFDYGFDGSYLGSPHRPSYGSGFDSSNFGPPIRPSYNSGFYGSQFGPPNRPNYGYDGSDFGPRKCCWRETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AAB7</accession>
    <name>A0A5N4AAB7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PPYR_13877</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">1611_PpyrPB1</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0794257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AAB7"/>
    <dbReference type="FunCoup" id="A0A5N4AAB7">
        <property type="interactions" value="66"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AAB7"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11056">
        <property type="entry name" value="CYP6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000042">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002402">
        <property type="entry name" value="Cyt_P450_E_grp-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050476">
        <property type="entry name" value="Insect_CytP450_Detox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292:SF54">
        <property type="entry name" value="CYP9F3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00464">
        <property type="entry name" value="EP450II"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0492">Microsome</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024454086" description="Cytochrome P450" evidence="15">
        <location>
            <begin position="19"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="469"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602402-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAB0794257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="526" mass="60757" checksum="5F89B569BCC2F279" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ABI5</accession>
    <name>A0A5N4ABI5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_11525</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0794686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ABI5"/>
    <dbReference type="FunCoup" id="A0A5N4ABI5">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4ABI5"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16021">
        <property type="entry name" value="ALP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06721">
        <property type="entry name" value="PDZ1_syntenin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06794">
        <property type="entry name" value="PDZ2_syntenin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000017">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000043">
        <property type="entry name" value="Syntenin-1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004245">
        <property type="entry name" value="DUF229"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10974:SF9">
        <property type="entry name" value="DUF229 DOMAIN CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10974">
        <property type="entry name" value="FI08016P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02995">
        <property type="entry name" value="DUF229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="113"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="197"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0794686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="943" mass="107686" checksum="718D50A7AA1EDF69" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ABV5</accession>
    <name>A0A5N4ABV5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rho GTPase-activating protein 100F</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PPYR_11635</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0794796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A5N4ABV5">
        <property type="interactions" value="15"/>
    </dbReference>
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    </dbReference>
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            <end position="204"/>
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            <begin position="749"/>
            <end position="884"/>
        </location>
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            <begin position="927"/>
            <end position="1142"/>
        </location>
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            <begin position="1"/>
            <end position="20"/>
        </location>
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            <end position="56"/>
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            <begin position="214"/>
            <end position="305"/>
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    </feature>
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            <end position="405"/>
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            <begin position="452"/>
            <end position="491"/>
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    <feature type="region of interest" description="Disordered" evidence="2">
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            <begin position="557"/>
            <end position="580"/>
        </location>
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            <begin position="658"/>
            <end position="721"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="781"/>
            <end position="802"/>
        </location>
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            <begin position="1144"/>
            <end position="1219"/>
        </location>
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            <begin position="1235"/>
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        </location>
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            <begin position="43"/>
            <end position="56"/>
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            <begin position="262"/>
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    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50004"/>
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        <source>
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        <source>
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            <dbReference type="EMBL" id="KAB0794796.1"/>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1544" mass="168637" checksum="B7186754CC14358B" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ACD7</accession>
    <name>A0A5N4ACD7_PHOPY</name>
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        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_11836</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAB0794997.1"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <end position="106"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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            <end position="521"/>
        </location>
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        <location>
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            <end position="29"/>
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        <location>
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        <location>
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            <end position="409"/>
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    </feature>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAB0794997.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="547" mass="64065" checksum="1140D939C31CA0D6" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-06-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ACL3</accession>
    <name>A0A5N4ACL3_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_11893</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
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        <lineage>
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            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
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            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0795054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="InParanoid" id="A0A5N4ACL3"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0795054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="77" mass="8647" checksum="311E00F225D1CC94" modified="2020-02-26" version="1">MLEGNEDDDVPMGGIKEAEDAFKEYSKFCKLRSVKSKIVNEKILLAYFSAIDLSIENRRVCGPTTPCLDPCCVCERI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-06-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ACX0</accession>
    <name>A0A5N4ACX0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_11990</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0795151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ACX0"/>
    <dbReference type="InParanoid" id="A0A5N4ACX0"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="3">
        <location>
            <begin position="162"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0795151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="222" mass="24378" checksum="EDBF577E884EAFDD" modified="2020-02-26" version="1">MAIKPPRMIGQRASKATIDKPANIPVVLSFSTILYQTRTGGFQSEIQLPLGMVVNAVFKNQNWLYVQTPHTEEGYVNYAACLPLGIIPPPTDSPVPCWENSTDVFPKPSGNMTDTEKLSSRSECSLSRCHSRRSRTAYSSCGEKSVDRLYLQAAACAKIKGTKQTLLVVYCDYQGKGENAISVTKGDVVVLVSSHLKGWFWIRNKHGHEGFIPSAVAGHGYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AD15</accession>
    <name>A0A5N4AD15_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_12043</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0795204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AD15"/>
    <dbReference type="InParanoid" id="A0A5N4AD15"/>
    <dbReference type="OrthoDB" id="6766294at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01644">
        <property type="entry name" value="RT_pepA17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008042">
        <property type="entry name" value="Retrotrans_Pao"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF1">
        <property type="entry name" value="GAG-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05380">
        <property type="entry name" value="Peptidase_A17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="262"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0795204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="480" mass="54111" checksum="598F5CDBACA53A60" modified="2020-02-26" version="1">MPSHIINTNSWSHISNLKLGDDRFHIPAPVDLLLGAEAFARILKEGRVLGQPGQPTALETVFGWVLLGKAQEVLTPSVHLQTYFSSFDSSLDSDIRKFWELEAIAAKPQIAPEEEKCEEIYRKTVSRDPSGRFIVSLPFRHSEPDLGDTFTIAYRSFKSLETRLIKNPELYNLYSEFMRNYLENGHMTLIASDEPKPIHSCYLPHHGVIKVEKTTSKVRVVFNASAKGSKGISLNDTLLPGPKLQADLSGILVKFRVFPIIFLADIKQMYLQIQLTPEHRDYQRLIWRFNPNDPIKQYRLNTVTFGVTSSPYLAIRTLKELAKQERSKYPNAADILLNNTFMDDICAGSDSLESALALQKEIIALLKAGGFELRKWASNHFKLLSSLAAADCQVPVSFDREVSSNIKVLGLLYNPSVDKFSFSHSPSNKPPTKRNILSEIARIFDPLGFLSPVTFLAKHIMQRLWISGIGWDEIPGQTNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AD81</accession>
    <name>A0A5N4AD81_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_12111</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0795272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AD81"/>
    <dbReference type="InParanoid" id="A0A5N4AD81"/>
    <dbReference type="OrthoDB" id="6784883at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="923"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="983"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0795272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1057" mass="117057" checksum="1572B14F63C023E7" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AEF1</accession>
    <name>A0A5N4AEF1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="5">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PPYR_09768</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">1611_PpyrPB1</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="5"/>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0795707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AEF1"/>
    <dbReference type="InParanoid" id="A0A5N4AEF1"/>
    <dbReference type="OrthoDB" id="6776505at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061025">
        <property type="term" value="P:membrane fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254:SF363">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE HACE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 12" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="14">
        <location>
            <begin position="289"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="14">
        <location>
            <begin position="547"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="62"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="67"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="12">
        <location>
            <position position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAB0795707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="617" mass="70132" checksum="0402C1EABA5A8520" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AF52</accession>
    <name>A0A5N4AF52_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CHK kinase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_10021</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0795960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AF52"/>
    <dbReference type="InParanoid" id="A0A5N4AF52"/>
    <dbReference type="OrthoDB" id="8250698at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015897">
        <property type="entry name" value="CHK_kinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004119">
        <property type="entry name" value="EcKL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012">
        <property type="entry name" value="PROTEIN KINASE-LIKE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012:SF30">
        <property type="entry name" value="PROTEIN KINASE-LIKE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02958">
        <property type="entry name" value="EcKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00587">
        <property type="entry name" value="CHK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="CHK kinase-like" evidence="2">
        <location>
            <begin position="129"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0795960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="410" mass="47777" checksum="4CDDB8EEB8C13F15" modified="2020-02-26" version="1">MSSSHSMVLTETQLKAFKEFLGHAGDYCISFSSGVDEGENFGGIIIRADVTWKEGNKECTSHYIIKCTPPSESLQRLIPVQTAFIIETYVYSRVLKEFNIIQREYNLRKPLDCFPVYYTSLPTTKEKMIVLQNVKELGYRHYDRFQPLDYPHLLCVVKEYARVHALTYAIRHYKPVLFEEFEANTENHVFHDFKYEGIMMVTQHRMDHALKALESIEDTTLYKKFACFAQNVRSVFEKLLNSKKKHRVISHIDCGIPNFLFKYDPSSGELLSTCIIDWQQARLESPAVDLVTFIFSAADKATRERYDELIMEYHKTFCSFLGEFGCDGEKLLPFEDLQEELMEFGLLGLIIGISLIYVYATVDQKVPDIFQTECPKEEFGFLYDLQDSSKFDKRVREAICDFNRFGYNFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AF92</accession>
    <name>A0A5N4AF92_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein kinase C</fullName>
            <ecNumber evidence="2">2.7.11.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PPYR_10027</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">1611_PpyrPB1</strain>
            <tissue evidence="19">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.13" evidence="2"/>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0795966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AF92"/>
    <dbReference type="InParanoid" id="A0A5N4AF92"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004697">
        <property type="term" value="F:diacylglycerol-dependent serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017158">
        <property type="term" value="P:regulation of calcium ion-dependent exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061669">
        <property type="term" value="P:spontaneous neurotransmitter secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20836">
        <property type="entry name" value="C1_cPKC_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04026">
        <property type="entry name" value="C2_PKC_alpha_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000012">
        <property type="entry name" value="Kinase C alpha type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000080">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000052">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020454">
        <property type="entry name" value="DAG/PE-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043566">
        <property type="entry name" value="Rabphilin/DOC2/Noc2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45729:SF9">
        <property type="entry name" value="DOUBLE C2-LIKE DOMAIN-CONTAINING PROTEIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45729">
        <property type="entry name" value="RABPHILIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00360">
        <property type="entry name" value="C2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00008">
        <property type="entry name" value="DAGPEDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="18">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="18">
        <location>
            <begin position="63"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="16">
        <location>
            <begin position="120"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="292"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="321"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAB0795966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="365" mass="41213" checksum="BC0C8FFB85478CF0" modified="2020-02-26" version="1">MGKGRVLPWTLRGSAPVQEKGFGKQGFQCQVCSFVVHKRCHEYVTFSCPGVDKGADSDDTRTRHNFKSHTYASPTFCDHCGSLLYGVIHQGMKCTACDMNVHKRCVESTPNLCGCDHTERRGRIQLKVNCVGNKLSVEVCQGRNLIPMDPNGASDPYVKIKLIPDNDNVKKKTKTIRANLNPVWNETLTFELKPEDKDRRLLIEVWDWDRTSRNDFMGSLSFGISEIIKSSTDGWFKLLTQEEGEFYNVPVPEEGVDLAQMKKTSITRKPTLADKDVPHNMGKLDVIRATDFNFLMVLGKGSFGKVMLAERKGTDELYAIKILKKDIIIQDDDVECTMVEKRVLALSSKPPFLRSVTLGFYYSIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AFM3</accession>
    <name>A0A5N4AFM3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MOSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_10201</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AFM3"/>
    <dbReference type="FunCoup" id="A0A5N4AFM3">
        <property type="interactions" value="41"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AFM3"/>
    <dbReference type="OrthoDB" id="17255at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005303">
        <property type="entry name" value="MOCOS_middle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237:SF19">
        <property type="entry name" value="MITOCHONDRIAL AMIDOXIME REDUCING COMPONENT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237">
        <property type="entry name" value="MOLYBDOPTERIN COFACTOR SULFURASE MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03473">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03476">
        <property type="entry name" value="MOSC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141673">
        <property type="entry name" value="MOSC N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="MOSC" evidence="2">
        <location>
            <begin position="175"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0796140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="327" mass="36646" checksum="6454A4EA9D1DFCE6" modified="2020-02-26" version="1">MINKSIVSAITLIGSAVGVVCYFYRRSRKICWKPIGTVGDLLIYPLKSGRRVSIKSAVCTQFGLEAGMLKDRCLVVYNEETKAFQTARNFPRLLLIETKTNKGGFTLISPGTVPLGITIPKLGNSREDYVVMWNGEKVFTIDCGDEAAEWISKTLLGYCYGLRLGYHDGSRKRDIRKFHSRYIEMYPKLKRATSGKYSDLSTILLLTDSSVNDVISRVTNVSKHNFRPNIVIGGANIEPYSEDNWDRIKVGDVVLKSVMPCPRCSITTIDPESGLHNEGFEPITTMKKYRKLTKYNSGLSYPNLGVYMSVEHPGRICVGDVVYIPDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AG53</accession>
    <name>A0A5N4AG53_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">1-phosphatidylinositol-3-phosphate 5-kinase</fullName>
            <ecNumber evidence="2">2.7.1.150</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PPYR_10340</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">1611_PpyrPB1</strain>
            <tissue evidence="20">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13609"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57923"/>
            <dbReference type="ChEBI" id="CHEBI:58088"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.150"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:13610"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.150" evidence="2"/>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A5N4AG53">
        <property type="interactions" value="1986"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AG53"/>
    <dbReference type="OrthoDB" id="158357at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000285">
        <property type="term" value="F:1-phosphatidylinositol-3-phosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052810">
        <property type="term" value="F:1-phosphatidylinositol-5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032438">
        <property type="term" value="P:melanosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090385">
        <property type="term" value="P:phagosome-lysosome fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046488">
        <property type="term" value="P:phosphatidylinositol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903426">
        <property type="term" value="P:regulation of reactive oxygen species biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03334">
        <property type="entry name" value="Fab1_TCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15725">
        <property type="entry name" value="FYVE_PIKfyve_Fab1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17300">
        <property type="entry name" value="PIPKc_PIKfyve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.810.10:FF:000001">
        <property type="entry name" value="1-phosphatidylinositol 3-phosphate 5-kinase FAB1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PInositol-4-P-4/5-kinase_C_sf"/>
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        <property type="entry name" value="PInositol-4-P-4/5-kinase_core"/>
    </dbReference>
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        <property type="entry name" value="PInositol-4-P-5-kinase_N"/>
    </dbReference>
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        <property type="entry name" value="WH-like_DNA-bd_sf"/>
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        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
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        <property type="entry name" value="Znf_FYVE-rel"/>
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        <property type="entry name" value="Znf_FYVE_PHD"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="11 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0967">Endosome</keyword>
    <keyword evidence="9 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="17">
        <location>
            <begin position="125"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="DEP" evidence="18">
        <location>
            <begin position="292"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="PIPK" evidence="19">
        <location>
            <begin position="1532"/>
            <end position="1861"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="393"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="774"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="828"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1370"/>
            <end position="1414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1501"/>
            <end position="1537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1559"/>
            <end position="1582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="776"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="828"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="838"/>
            <end position="852"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00052820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAB0796279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1877" mass="212910" checksum="43FBFFF893261857" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AGS9</accession>
    <name>A0A5N4AGS9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_10606</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="5"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0796545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="568" mass="65488" checksum="C8BDC96774FE3CF9" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AIA7</accession>
    <name>A0A5N4AIA7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Inter-alpha-trypsin inhibitor heavy chain H4-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_08089</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="InParanoid" id="A0A5N4AIA7"/>
    <dbReference type="OrthoDB" id="299997at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050934">
        <property type="entry name" value="ITIH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013694">
        <property type="entry name" value="VIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10338">
        <property type="entry name" value="INTER-ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10338:SF108">
        <property type="entry name" value="INTER-ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN H4-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08487">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00609">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51468">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024366636" description="Inter-alpha-trypsin inhibitor heavy chain H4-like" evidence="1">
        <location>
            <begin position="25"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="domain" description="VIT" evidence="3">
        <location>
            <begin position="43"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="310"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0797095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="785" mass="86515" checksum="E3286F74EC71BA4A" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AJ14</accession>
    <name>A0A5N4AJ14_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_08270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AJ14"/>
    <dbReference type="InParanoid" id="A0A5N4AJ14"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0797276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="182" mass="21110" checksum="8DA9B6364261B9D4" modified="2020-02-26" version="1">MELFEEKTYFKTLRSIPAFTGFNLEEKLNMKQKVCLWLVPMMTCVYAGFVLLKEWKLTDDINDFLYTSVLAIAWQRVFIMRIQRSRLAKLLILLEKFPMDDKEVKSHLNAILTKVVTIFVTLPPIAVVSGVVAWYTTYGEGTLPFGSMASWAMEYTTNMCLVIQVMTYTFLGHEFLMWDGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ALK9</accession>
    <name>A0A5N4ALK9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_09213</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ALK9"/>
    <dbReference type="InParanoid" id="A0A5N4ALK9"/>
    <dbReference type="OrthoDB" id="6247875at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007420">
        <property type="term" value="P:brain development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01388">
        <property type="entry name" value="HMG-box_SoxB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000002">
        <property type="entry name" value="transcription factor Sox-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050140">
        <property type="entry name" value="SRY-related_HMG-box_TF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270:SF324">
        <property type="entry name" value="SOX DOMAIN-CONTAINING PROTEIN DICHAETE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270">
        <property type="entry name" value="SOX TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="6">
        <location>
            <begin position="43"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="4">
        <location>
            <begin position="43"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="282"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="282"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="297"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="308"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0798220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="373" mass="40565" checksum="33FD4150F12080B7" modified="2020-02-26" version="1">MCDGGFSAAEGLSRMASLGGAALGVPQGLAGPQTPKKHQDDHIKRPMNAFMVWSRLQRRKIAQENPKMHNSEISKRLGSEWKLLTEDEKRPFIDEAKRLRALHMKEHPDYKYRPRRKPKTLRKEGYPYSIPYPSVPMDALRAGMAASSMTQSMASYYNPSAAYGSLSAASIAAAAAAQQSMSAGLTSPAQVVSSMDAMKYSMEADKYRSAYMPPSSLAMSMYSDPKYMDTSSKSYLERGYLDSTSALTKAYFESSKMYMDGKYNPDSARHYSLDIGKMYSDASPTMPSNLASPKSSDSPDTKPERQDGTSSSSSTTTSSAGASPGGLPGYYPGSALQQNSAMPSGLLPMSQYPGQYSAQGPAGEFRRPLTVIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ANY4</accession>
    <name>A0A5N4ANY4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="24">Neurotransmitter-gated ion-channel ligand-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">PPYR_06808</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">1611_PpyrPB1</strain>
            <tissue evidence="22">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="17">Postsynaptic cell membrane</location>
            <topology evidence="17">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0798928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ANY4"/>
    <dbReference type="FunCoup" id="A0A5N4ANY4">
        <property type="interactions" value="137"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4ANY4"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034707">
        <property type="term" value="C:chloride channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004890">
        <property type="term" value="F:GABA-A receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099095">
        <property type="term" value="F:ligand-gated monoatomic anion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19007">
        <property type="entry name" value="LGIC_ECD_GABAR_GRD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19049">
        <property type="entry name" value="LGIC_TM_anion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000087">
        <property type="entry name" value="GABA-gated ion channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000118">
        <property type="entry name" value="GABA-gated ion channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000043">
        <property type="entry name" value="Gamma-aminobutyric acid receptor alpha-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001390">
        <property type="entry name" value="GABAAa_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00860">
        <property type="entry name" value="LIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01079">
        <property type="entry name" value="GABAARALPHA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0868">Chloride</keyword>
    <keyword evidence="11" id="KW-0869">Chloride channel</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="16 18" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 18" id="KW-0406">Ion transport</keyword>
    <keyword evidence="15" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 18" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0770">Synapse</keyword>
    <keyword evidence="3 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 18" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024469182" description="Neurotransmitter-gated ion-channel ligand-binding domain-containing protein" evidence="18">
        <location>
            <begin position="18"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="279"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="311"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="481"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="20">
        <location>
            <begin position="38"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="21">
        <location>
            <begin position="254"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="348"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="358"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="379"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAB0798928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="24">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="512" mass="58658" checksum="DB0CA2C750804A56" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AQ05</accession>
    <name>A0A5N4AQ05_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_07290</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AQ05"/>
    <dbReference type="InParanoid" id="A0A5N4AQ05"/>
    <dbReference type="OrthoDB" id="6759828at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000176">
        <property type="entry name" value="pancreas/duodenum homeobox protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45664:SF12">
        <property type="entry name" value="PANCREAS_DUODENUM HOMEOBOX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45664">
        <property type="entry name" value="PROTEIN ZERKNUELLT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="182"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="184"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="241"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="62"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="246"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="278"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0799410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="442" mass="49760" checksum="B2A2EE339926B1F5" modified="2020-02-26" version="1">MSSSSERDSPDNNNENEEANKFWTPLKNYQSSEVSRKKRTFDEISDGGVRQYDMTLNGFKTNMDRHGAPQEKNTELSKSPPPYPAYGSNPNFHPSDFSNMIPSQLNGNASPAYSDYGQQNSGYDILGNYNLPSWTSAHQDSVTLPTNLSNHEKPLNLNSNYNSQNTADFHDHPVALQTGTGTGTKRARTAYTSSQLVELEKEFHYNKYLCRPRRIQMAQILNLTERQIKIWFQNRRMKFKKEQKAKSSSPNALSQNDNPSPPALSPCSNNSGGGYTPLATQPQSQSTKLTNDQQAIVNKLLSHSPTPVPQQQYLPTSLSTLPAYTRMALPDNEVIDKHYYENLQMQARNLAEMSYSYNLQFNTYNDVYTSGMFPNSEGSGQSDEYIVPKRETLSPDSELLDYDKVNETDNRINGYNFGPSVNAAWIGQQYVDNVNAASLTQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AQ47</accession>
    <name>A0A5N4AQ47_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_07334</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AQ47"/>
    <dbReference type="InParanoid" id="A0A5N4AQ47"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33053">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33053:SF25">
        <property type="entry name" value="TRANSPOSASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0799454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="344" mass="39040" checksum="E963CBD7AB2D326F" modified="2020-02-26" version="1">MSRRCRRSMFVKRSLMEVGSAVNFKLPIYNRNELENNVLLNAPSSSSLIRTTLLQTETLENDIGMDLCNNSPSGLSFTSNSPKTLALNYPTTPAKQLSLTEQLKLWAITTNVNHKQLSSLLSVLKSFHPELPKSSKTLLKTVRKLNYTPMQSADNSRGKFCYFGIENGIRHQLKISPFAVAIFEGNNKPGSLNQFLDNFITEKINSLSSTGFVYQGVKITVSLKYMICDAPARSFLKNIKPHNSYFACEKCNVKGLRMQNRILYPCNSNIEIRTDEGFLNQVHKEHHKGLSPLTKIPHFGMVSGFILDYMHMSCLGTMRRLIQYWFKPSWKCCISLSLRTEASF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AQV0</accession>
    <name>A0A5N4AQV0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_07615</name>
        <name evidence="3" type="ORF">PPYR_07705</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AQV0"/>
    <dbReference type="FunCoup" id="A0A5N4AQV0">
        <property type="interactions" value="12"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AQV0"/>
    <dbReference type="OrthoDB" id="66144at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861:SF1">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="1">
        <location>
            <begin position="38"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0799735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0799825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="276" mass="32181" checksum="494B2AB9CDBE743E" modified="2020-02-26" version="1">MNQALLYSKYNGLQKNDAIYVLDNYFDLIKWRKDASILDVGCGAGDVIRDLLLPRLPKKFEKLVGVDLSEEMIEFAKNNCQNSKIAFEHMNIATDDIPVEFEENFDHILSFYCLHWVQDQRKALANIYKMLKEDGDVLLAFLANNPIFEIYQSLSKKGRWESYMENVKNYVSPYQYSENPDKQLEEILLDVGFDIDICKTEDRIYVYPNVAVLKKSITAVSPFYSQIPSKMHEDYLSDCVKEVKKLHLFDECDNNNEQRVQVPYKLFVVHASKRSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ARB1</accession>
    <name>A0A5N4ARB1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">palmitoyl-protein hydrolase</fullName>
            <ecNumber evidence="2">3.1.2.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_07747</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.22" evidence="2"/>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ARB1"/>
    <dbReference type="FunCoup" id="A0A5N4ARB1">
        <property type="interactions" value="521"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4ARB1"/>
    <dbReference type="OrthoDB" id="2418081at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050565">
        <property type="entry name" value="LYPA1-2/EST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655:SF17">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phospholipase/carboxylesterase/thioesterase" evidence="4">
        <location>
            <begin position="10"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0799867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="226" mass="24834" checksum="7E9B1E03FEC74FE2" modified="2020-02-26" version="1">MSLSLGVLKTIAQTNAKNTATVIFLHGSGDTGPGVCEWIESLVGSFSFPNIKFLFPTAPLQSYTAAGGEMRHVWFDRKSISIEAEESVESIDEIGSVINNLIEEEVSSGIPLNKIIVGGFSMGGGLALHVGYRLRLGLRGVFALSSFLNRDSQVFYNLKTHSTADTPLLMYHGERDSLVPIKWGRATYDTLESLGVGGDFVSLPNTIHELKKRELEELFEWIKKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AST6</accession>
    <name>A0A5N4AST6_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_06040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000004">
        <property type="protein sequence ID" value="KAB0800300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AST6"/>
    <dbReference type="InParanoid" id="A0A5N4AST6"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024298690" evidence="2">
        <location>
            <begin position="16"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="204"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0800300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="264" mass="27847" checksum="7419A7F32EB33B2E" modified="2020-02-26" version="1">MEVAVTLTSILAVLAIINVQNTAMSSPLHHLTLQDLSPSDRQYLDYLRSEAIRRKRSGDILGSVKSKLSHGFKSKLSGLTSASAHASSLFSGASGSKFSHYPPPPPPIDEEKSFSFWDLQKAIFRTLFQAAKAIKGGLLAVKGQIIKGSGYLISAKGKLISAKGEALSNIGKQIASTAVLISPVGHNTAPSGIVEPVYMSPPSGYSGTSGPSATGGPSGPSGQSIDDYHAHHYEHSPPGSDEHSYPSSFEGPAHSYYDGSSYYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ASX6</accession>
    <name>A0A5N4ASX6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Bifunctional purine biosynthesis protein ATIC</fullName>
            <ecNumber evidence="6">2.1.2.3</ecNumber>
            <ecNumber evidence="7">3.5.4.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">AICAR transformylase/inosine monophosphate cyclohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PPYR_06167</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">1611_PpyrPB1</strain>
            <tissue evidence="20">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Bifunctional enzyme that catalyzes the last two steps of purine biosynthesis. Acts as a transformylase that incorporates a formyl group to the AMP analog AICAR (5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) to produce the intermediate formyl-AICAR (FAICAR). Can use both 10-formyldihydrofolate and 10-formyltetrahydrofolate as the formyl donor in this reaction. Also catalyzes the cyclization of FAICAR to inosine monophosphate (IMP). Promotes insulin receptor/INSR autophosphorylation and is involved in INSR internalization.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>(6R)-10-formyltetrahydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + (6S)-5,6,7,8-tetrahydrofolate</text>
            <dbReference type="Rhea" id="RHEA:22192"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:58467"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="ChEBI" id="CHEBI:195366"/>
            <dbReference type="EC" id="2.1.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:22193"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>10-formyldihydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + 7,8-dihydrofolate</text>
            <dbReference type="Rhea" id="RHEA:59144"/>
            <dbReference type="ChEBI" id="CHEBI:57451"/>
            <dbReference type="ChEBI" id="CHEBI:57452"/>
            <dbReference type="ChEBI" id="CHEBI:58467"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:59145"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:18445"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58467"/>
            <dbReference type="EC" id="3.5.4.10"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="17">
            <dbReference type="Rhea" id="RHEA:18447"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homodimer. Associates with internalized INSR complexes on Golgi/endosomal membranes. Interacts with INSR; ATIC together with PRKAA2/AMPK2 and HACD3/PTPLAD1 is proposed to be part of a signaling network regulating INSR autophosphorylation and endocytosis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PurH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.3" evidence="6"/>
    <dbReference type="EC" id="3.5.4.10" evidence="7"/>
    <dbReference type="EMBL" id="VVIM01000004">
        <property type="protein sequence ID" value="KAB0800427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ASX6"/>
    <dbReference type="FunCoup" id="A0A5N4ASX6">
        <property type="interactions" value="1666"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4ASX6"/>
    <dbReference type="OrthoDB" id="6017153at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00133"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003937">
        <property type="term" value="F:IMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004643">
        <property type="term" value="F:phosphoribosylaminoimidazolecarboxamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01421">
        <property type="entry name" value="IMPCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.20:FF:000003">
        <property type="entry name" value="Bifunctional purine biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1380:FF:000003">
        <property type="entry name" value="Bifunctional purine biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.440:FF:000001">
        <property type="entry name" value="Bifunctional purine biosynthesis protein PURH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="entry name" value="Methylglyoxal synthase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00139">
        <property type="entry name" value="PurH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024051">
        <property type="entry name" value="AICAR_Tfase_dup_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024050">
        <property type="entry name" value="AICAR_Tfase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002695">
        <property type="entry name" value="PurH-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005492">
        <property type="entry name" value="PRK07106.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00355">
        <property type="entry name" value="purH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11692:SF0">
        <property type="entry name" value="BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN ATIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11692">
        <property type="entry name" value="BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN PURH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01808">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02142">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000414">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00798">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00851">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="Methylglyoxal synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="11" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MGS-like" evidence="19">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00017905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00046691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00053070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAB0800427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="593" mass="65051" checksum="4946D0AC40DE68AE" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ATF1</accession>
    <name>A0A5N4ATF1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ZP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_06248</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000004">
        <property type="protein sequence ID" value="KAB0800508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ATF1"/>
    <dbReference type="FunCoup" id="A0A5N4ATF1">
        <property type="interactions" value="9"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4ATF1"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056953">
        <property type="entry name" value="CUT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055355">
        <property type="entry name" value="ZP-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46560">
        <property type="entry name" value="CYPHER, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46560:SF4">
        <property type="entry name" value="DUSKY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25057">
        <property type="entry name" value="CUT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00100">
        <property type="entry name" value="Zona_pellucida"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00241">
        <property type="entry name" value="ZP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51034">
        <property type="entry name" value="ZP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="388"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="ZP" evidence="2">
        <location>
            <begin position="27"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0800508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="446" mass="49379" checksum="8C5FE52345E74A52" modified="2020-02-26" version="1">MEKYGSGGEIWPAPVPEMPKIISLDVKCEKSLMKVYIGFDKPFYGIVFSKGHYSNVHCVHLPAGLGRTSAHFEIGIHACGTSGNTENGLYGYGAESGSGTYFENIIVIQYDPQVQEVWDQARKLRCTWHDQYEKSVTFRPFPVDMLDVVRTDFAGDNVGCWMQIQVGKGPWASEVSGLVKIGQTMTMVLAIKDDDSKFDMLVRNCMAHDGKRAPIQLIDQKGCVTRPKLMSRFTKIKNFGASASVLSYAHFQAFKFPDSMEVHFQCTIQICRYQCPDQCSDGSNLHLLHNGITDLAHVSPDTGYGAPHIPLPLEAYLQSGRPRDERRLKRAVTTDPEKEVGVNRVIRVVSTGDLTFSLDDNGTATAPTMVFSTKEEILNPGLICMTTVGFTATLIILLSILIGSCLMSTFLCFKLKPFSINNKVASNFGATSPKDKKTMPKSCFYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ATJ8</accession>
    <name>A0A5N4ATJ8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidase M20 dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PPYR_06444</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000004">
        <property type="protein sequence ID" value="KAB0800705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ATJ8"/>
    <dbReference type="InParanoid" id="A0A5N4ATJ8"/>
    <dbReference type="OrthoDB" id="7832001at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05676">
        <property type="entry name" value="M20_dipept_like_CNDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051458">
        <property type="entry name" value="Cyt/Met_Dipeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43270">
        <property type="entry name" value="BETA-ALA-HIS DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43270:SF4">
        <property type="entry name" value="CARNOSINE DIPEPTIDASE 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00759">
        <property type="entry name" value="ARGE_DAPE_CPG2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="5">
        <location>
            <begin position="211"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0800705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="478" mass="53094" checksum="10667E75EB43C027" modified="2020-02-26" version="1">MEVPTALEELFKYIDKNTSRYIETLREAVAIRSVSSLEECREETCKMVNWTAGHLRKLGVEVCLKEIGTQVFPSGNEVKFPPVLLGTLGNDPKKKTICIYGHLDVQPALKDDGWNTEPFEMAECDGRLYGRGAADDKGPVLACIQAIEAFQAVHVELPVNIKILFEAMEECGSLGLEGLVTSEKDSFFKDVDYICICDGSWLGKDTPCIVYGLRGCCFFRLTVECASQDLHSGVHGGMVHEAMADLTYLLSSLTDKDGRLLITDIYNSVPPLHAGEQDIYTNIDFDTSVYGNDIGAVKLLRQDKADLLLNGWRYPSLSIHGIEGAHGEFGLKCVIPGKVTGKFSIRIVENQSPEEVKKLVTDYLTKKWQERGSATRIMVTMTASALPWHEDPHHPHYLATQKATKYIYKKDGDLIRAGGTMPIITTLKKITGKNIINVALSAGDDNIHAQNEKIDKNNYISGTKFMAAYLYEVSRIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AU38</accession>
    <name>A0A5N4AU38_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Centrosomal protein of 290kDa coiled-coil region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PPYR_06469</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Centrosome</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000004">
        <property type="protein sequence ID" value="KAB0800730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A5N4AU38">
        <property type="interactions" value="62"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AU38"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034451">
        <property type="term" value="C:centriolar satellite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035869">
        <property type="term" value="C:ciliary transition zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097711">
        <property type="term" value="P:ciliary basal body-plasma membrane docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905349">
        <property type="term" value="P:ciliary transition zone assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026201">
        <property type="entry name" value="Cep290"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18879">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 290 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18879:SF20">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 290 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="5 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="333"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="460"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="632"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="705"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="972"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="1172"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="1249"/>
            <end position="1279"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="1359"/>
            <end position="1414"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="1469"/>
            <end position="1496"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="1608"/>
            <end position="1799"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="1841"/>
            <end position="1906"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="1948"/>
            <end position="2082"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0800730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2095" mass="243994" checksum="731063C925617B89" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AVW4</accession>
    <name>A0A5N4AVW4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PPYR_05828</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000003">
        <property type="protein sequence ID" value="KAB0801474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AVW4"/>
    <dbReference type="InParanoid" id="A0A5N4AVW4"/>
    <dbReference type="OrthoDB" id="243840at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037781">
        <property type="entry name" value="SKAP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15129:SF0">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15129">
        <property type="entry name" value="SRC-ASSOCIATED ADAPTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="5">
        <location>
            <begin position="134"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="283"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="391"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="283"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="316"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="349"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="409"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0801474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="435" mass="49584" checksum="B8564DA56BCD2217" modified="2020-02-26" version="1">MSVNKSVKAHLGAKMTNGDINLLYAEVDRLLHDICKFLHDEIRDGYISPNGKNLANSLIDRSKKQLQTISMTVSLDTNESYVDMQAYKVNQRLDYPELEVYSDVSTYEPTSGLSIAGEDQIICPYSNLPASEIREGKMGHLYKKEKILFFEQHKKVFAAIYHAWFLIYANENALKPCQTFDLSRYEVKPSSAQSKDIKRRDESFDLMCISDSKLHQFTASTPKDMQQWLSTLKLQIDMIVTKRSLPPIPANKVQEDFFRISAELEGDHYEPLKNYMIKEKDEHHSAESLEVKGDTLPLPPRNPNKNIPKPYLPPASSEDSLSSNYDSVTPGFINPSRESSNSFSEDDSDTHYDDPSEITHRPTPINPNDRIQADDDEDDIYDCLSAFQESKAPINQHHKNEIQVPSPPSKVQSKPVPSLKPKLILSFRQRKKSEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AYQ6</accession>
    <name>A0A5N4AYQ6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">Nicotinic acetylcholine receptor alpha 3 subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">PPYR_04599</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">1611_PpyrPB1</strain>
            <tissue evidence="21">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="17">Postsynaptic cell membrane</location>
            <topology evidence="17">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AYQ6"/>
    <dbReference type="FunCoup" id="A0A5N4AYQ6">
        <property type="interactions" value="53"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AYQ6"/>
    <dbReference type="OrthoDB" id="5975154at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022848">
        <property type="term" value="F:acetylcholine-gated monoatomic cation-selective channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007271">
        <property type="term" value="P:synaptic transmission, cholinergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19031">
        <property type="entry name" value="LGIC_ECD_nAChR_proto_alpha-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19064">
        <property type="entry name" value="LGIC_TM_nAChR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000013">
        <property type="entry name" value="Acetylcholine receptor subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000012">
        <property type="entry name" value="Acetylcholine receptor subunit alpha-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000022">
        <property type="entry name" value="Nicotinic acetylcholine receptor subunit alpha4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002394">
        <property type="entry name" value="Nicotinic_acetylcholine_rcpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00860">
        <property type="entry name" value="LIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00254">
        <property type="entry name" value="NICOTINICR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="16 18" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9 18" id="KW-0406">Ion transport</keyword>
    <keyword evidence="15" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="10 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 18" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0770">Synapse</keyword>
    <keyword evidence="5 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 18" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024482880" description="Nicotinic acetylcholine receptor alpha 3 subunit" evidence="18">
        <location>
            <begin position="21"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="240"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="275"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="504"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="19">
        <location>
            <begin position="25"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="20">
        <location>
            <begin position="246"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAB0802413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="23">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="554" mass="63456" checksum="F6D2C43BA73D3AC1" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2024-07-24" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B303</accession>
    <name>A0A5N4B303_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Peptidase M13 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PPYR_00916</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B303"/>
    <dbReference type="InParanoid" id="A0A5N4B303"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08662">
        <property type="entry name" value="M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF224">
        <property type="entry name" value="NEPRILYSIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00786">
        <property type="entry name" value="NEPRILYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="24"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="11">
        <location>
            <begin position="75"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="10">
        <location>
            <begin position="529"/>
            <end position="735"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAB0803946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="736" mass="85178" checksum="510FAE0EC4A7ECB0" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B3J2</accession>
    <name>A0A5N4B3J2_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PPYR_01132</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B3J2"/>
    <dbReference type="InParanoid" id="A0A5N4B3J2"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000050">
        <property type="entry name" value="UDP-glucuronosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035595">
        <property type="entry name" value="UDP_glycos_trans_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF159">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00375">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="482"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="525"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0804162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="558" mass="63344" checksum="5F4DB5C195683EAC" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B3V7</accession>
    <name>A0A5N4B3V7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Microsomal glutathione S-transferase 1</fullName>
            <ecNumber evidence="5">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PPYR_01204</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">1611_PpyrPB1</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:16438"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="14">Homotrimer; The trimer binds only one molecule of glutathione.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MAPEG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="5"/>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B3V7"/>
    <dbReference type="FunCoup" id="A0A5N4B3V7">
        <property type="interactions" value="493"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4B3V7"/>
    <dbReference type="OrthoDB" id="193139at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.550:FF:000002">
        <property type="entry name" value="Microsomal glutathione S-transferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.550">
        <property type="entry name" value="Membrane associated eicosanoid/glutathione metabolism-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023352">
        <property type="entry name" value="MAPEG-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001129">
        <property type="entry name" value="Membr-assoc_MAPEG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040162">
        <property type="entry name" value="MGST1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10689">
        <property type="entry name" value="MICROSOMAL GLUTATHIONE S-TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10689:SF6">
        <property type="entry name" value="MICROSOMAL GLUTATHIONE S-TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01124">
        <property type="entry name" value="MAPEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161084">
        <property type="entry name" value="MAPEG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00039397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAB0804234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="151" mass="17311" checksum="E4682335D9965482" modified="2020-02-26" version="1">MGGLSLLSLENQVFRCYLTYTSILVLKMMLMSILTSVQRRKHGVLTSPEDAPLLKPLRKSHDDVDRVRRAHLNDMENIPLFFVVGFTYILTNPAPLIASYIFRIYTVSRIIHTFVYAIYVIPQPARGLAWVVGYLVNAYMAVRTIITFATW</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B5Q0</accession>
    <name>A0A5N4B5Q0_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_01917</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B5Q0"/>
    <dbReference type="InParanoid" id="A0A5N4B5Q0"/>
    <dbReference type="OrthoDB" id="7643562at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024406087" evidence="1">
        <location>
            <begin position="24"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0804947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="145" mass="15950" checksum="6EEE2E6CC54AB7D5" modified="2020-02-26" version="1">MLVTMFKIILVVIFCSAVRIACGEESSGPQQISTTAKYHDGNNCECSVFNTSEPCPDHTAIMIESVLQVECNEEGKATCTDMCKALALAAHDKSPKILCSHLGDYNNLEVFLHSRICGSEWQYTGLNRGNLCCKKSEVVECVHEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B5T3</accession>
    <name>A0A5N4B5T3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="4">PPIase</shortName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PPYR_01935</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B5T3"/>
    <dbReference type="InParanoid" id="A0A5N4B5T3"/>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000001">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0697">Rotamase</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024480859" description="Peptidyl-prolyl cis-trans isomerase" evidence="4">
        <location>
            <begin position="18"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="5">
        <location>
            <begin position="30"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0804965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="203" mass="22357" checksum="84127CF334B4C0F6" modified="2020-02-26" version="1">MYFLLFSVSLLIVGCYASSDEDLKVTSKVRFDIEIGGNSVGTVTIGLFGEIVPLTTDNFFQLCEKPKGEGYVGSKFHRVIKKFMIQGGDFTRGDGSGGRSIYGARFADENFVLKHYGAGWLSMANAGKDTNGSQFFITTVLTSWLDGKHVVFGKVLEGMSVIRKIEETETGRNDRPNQDVVIAKCSAERLNEPIFVSRNDAKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B642</accession>
    <name>A0A5N4B642_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tyr recombinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_02042</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0805072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B642"/>
    <dbReference type="InParanoid" id="A0A5N4B642"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="entry name" value="Intergrase catalytic core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0805072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="219" mass="25001" checksum="6812A08F096114B3" modified="2020-02-26" version="1">MSVPQAIVDEATNVAASLLPEKSSARYEHEYAEFKKWQNENNVTGITEDVLLAYISSLSKKFSPNSLWSKWSMVKSCLQVRENIDGRRFHKVIAFLKRRNERYVPKKAKTLTKEHVEKFILEAPDDKWLLAEVITIFGIFGCCRCDELLSLTLNDVEDLEKYIVVTLRETKNLTTRRFTITDDGSDLTSSSGVINISGSKNCTMVFNVYDKAQFANVNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B6T4</accession>
    <name>A0A5N4B6T4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Putative nuclease HARBI1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Harbinger transposase-derived nuclease</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PPYR_02279</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Transposase-derived protein that may have nuclease activity. Does not have transposase activity.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HARBI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0805309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B6T4"/>
    <dbReference type="InParanoid" id="A0A5N4B6T4"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026103">
        <property type="entry name" value="HARBI1_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF289">
        <property type="entry name" value="DDE TNP4 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02086">
        <property type="entry name" value="PUTNUCHARBI1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="13">
        <location>
            <begin position="155"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAB0805309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="355" mass="40362" checksum="211E48E39175968B" modified="2020-02-26" version="1">MDEDFRDLFSSSDEELLGVEVHRPYTIRERNHHFDDWDDVDFFRRFRLSKQSVEVVLNLIQNQIQHRTNRNHAISPMNQLLIALRFYAVGNPYAAAGDFGGVHKSTAGVIIKRVTTAISTLRRQFVSLPTTPDEVTSTQEGFYNIARFPRVLGAIDCTHVRIKSPGGERAENFRNRKGYFSLNVQVVADSKLRITDIVARWPGSSHDSTIFHNSRLKYRLESGEFRDGLLLGDSGYGVKRYLIPPLANPGNASEHLFNESQIRTRNVVERTFGVWKKRFPILSIGMEQSLPLVQDIIVTTAILHNIACDNGELLEDDLEQIENEQNNGLNNFGALDVGDNAVRNALIYDYFARLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B780</accession>
    <name>A0A5N4B780_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_02388</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0805418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B780"/>
    <dbReference type="InParanoid" id="A0A5N4B780"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0805418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="154" mass="17648" checksum="33F74E891EC375E4" modified="2020-02-26" version="1">MIFNGIQVAALAKLFPPKGRINTKKHWKPSIVECQESIINLVSTCGEIEECINNRIKKLSDLGVTDQPYLIAVGKGFSEITESYVIIDKHVYKSISVLHSLDFLFQSFHVLNARYPLESEHIWLLIERALYKIEHSKIKSPAVLTILKEHENFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B791</accession>
    <name>A0A5N4B791_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RdRp catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_02398</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0805428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B791"/>
    <dbReference type="InParanoid" id="A0A5N4B791"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1850.10">
        <property type="entry name" value="RNA-directed RNA polymerase lambda-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22212">
        <property type="entry name" value="CPV_RdRP_pol_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="867"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1212"/>
            <end position="1235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0805428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1240" mass="140333" checksum="7C0CA92FBFB03ACB" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B798</accession>
    <name>A0A5N4B798_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chitin-binding type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_02449</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
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            <taxon>Elateroidea</taxon>
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            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0805479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4B798"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
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        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052976">
        <property type="entry name" value="Scoloptoxin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22933:SF40">
        <property type="entry name" value="CUTICULAR PROTEIN ANALOGOUS TO PERITROPHINS 1-H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22933">
        <property type="entry name" value="FI18007P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024405479" description="Chitin-binding type-2 domain-containing protein" evidence="2">
        <location>
            <begin position="26"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="3">
        <location>
            <begin position="109"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="251"/>
        </location>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
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            <begin position="266"/>
            <end position="351"/>
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            <begin position="359"/>
            <end position="377"/>
        </location>
    </feature>
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        <location>
            <begin position="380"/>
            <end position="399"/>
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    </feature>
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        <location>
            <begin position="455"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="631"/>
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        <source>
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        <source>
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        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
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            <dbReference type="EMBL" id="KAB0805479.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="763" mass="89124" checksum="C2F39C9334B5BE82" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B7G6</accession>
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        </submittedName>
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        <name type="common">Common eastern firefly</name>
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            <taxon>Pterygota</taxon>
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            <taxon>Coleoptera</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
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                <person name="Lower S.E."/>
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                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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            <begin position="116"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0805547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="129" mass="14139" checksum="48692AA17646053D" modified="2020-02-26" version="1">MNESLRTENKKQMKWNIKRSKPGFMVPGPPTLFGPVAQTTVVSCTAKPIPLHYPRASDITLAHHIKWKHPKSILSEPTAKVTLSIYTLGKGPTSRDNRIREERESEGGGGGGSSRKGNASAAQSFSKWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B7R7</accession>
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            <fullName evidence="1">PiggyBac transposable element-derived protein domain-containing protein</fullName>
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        <name evidence="2" type="ORF">PPYR_02574</name>
    </gene>
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        <name type="common">Common eastern firefly</name>
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            <taxon>Neoptera</taxon>
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            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
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            <taxon>Elateroidea</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
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                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
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            <dbReference type="PubMed" id="30324905"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
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    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0805604.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
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    </evidence>
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    <name>A0A1Y1JW83_PHOPY</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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        <name evidence="3" type="ORF">PPYR_05676</name>
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    <organism evidence="2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
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            <taxon>Neoptera</taxon>
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            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
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                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01099006">
        <property type="protein sequence ID" value="JAV53579.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
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        </location>
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        </location>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
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            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="383"/>
            <end position="392"/>
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        <location>
            <begin position="393"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="JAV53579.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAB0801322.1"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="518" mass="58682" checksum="BC443FC6E2167FDA" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1JX88</accession>
    <name>A0A1Y1JX88_PHOPY</name>
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        <recommendedName>
            <fullName evidence="8">Lipase maturation factor</fullName>
        </recommendedName>
    </protein>
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        <name evidence="12" type="ORF">PPYR_14009</name>
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    <organism evidence="11">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
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            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
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            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
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                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
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            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
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        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
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        <text evidence="8">Involved in the maturation of specific proteins in the endoplasmic reticulum.</text>
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    <comment type="subcellular location">
        <subcellularLocation>
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    </dbReference>
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    </feature>
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    </feature>
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    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="432"/>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        <source>
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    </evidence>
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</entry>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
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                <person name="Al-Wathiqui N."/>
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                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
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            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
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            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
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        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldolase class II family. Adducin subfamily.</text>
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        <property type="protein sequence ID" value="JAV52625.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051017">
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        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672">
        <property type="entry name" value="ADDUCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672:SF3">
        <property type="entry name" value="PROTEIN HU-LI TAI SHAO"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="AraD/HMP-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="121"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="588"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="598"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="630"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="670"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="713"/>
            <end position="733"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="JAV52625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0802667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="739" mass="82525" checksum="11B4C1CA0EE0BF0F" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1K1W6</accession>
    <name>A0A1Y1K1W6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Peroxisomal membrane protein PEX16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_08298</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the peroxin-16 family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01095216">
        <property type="protein sequence ID" value="JAV55454.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1K1W6"/>
    <dbReference type="FunCoup" id="A0A1Y1K1W6">
        <property type="interactions" value="1785"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1K1W6"/>
    <dbReference type="OrthoDB" id="2021143at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013919">
        <property type="entry name" value="Pex16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13299">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13299:SF0">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08610">
        <property type="entry name" value="Pex16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="3" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU365003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="JAV55454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0797304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="340" mass="39382" checksum="93D0FD9785365790" modified="2017-08-30" version="1">MSSALFSLPDLYNSYKSWVTKHPQTTSDFETTVKWVSYFIAGRINNSYIVSELVYSLSNLLVLFNDRIISQSHMNQPSSSQEVLKVWLTVLEYSEVFLELSALKLWGNHGKWFVIVCIQVFKCVSRMLLIFNYKDTVIENPPIPVLQRNNLDSKAVNENYTETQTHSISFTLQHSGRVIRKIDSSPPIAFRSWKPLEAVDCSGTQVVQQSILDKQLMAETLYALKPILHLGSVAYFGNNTWKPWIISLALDLYSLRLYRNCSKIDKMALSKKQKQQISRRTVVLLLYLLRSPFYDRHSKERISASLKCMAAKVPLANMICNPVLQYLPFWQKTYFYMWST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1KCD3</accession>
    <name>A0A1Y1KCD3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Fatty acid 2-hydroxylase</fullName>
            <ecNumber evidence="18">1.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">PPYR_00057</name>
    </gene>
    <organism evidence="23">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="24 25" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">1611_PpyrPB1</strain>
            <tissue evidence="24">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="24">1611_PpyrPB1</strain>
            <tissue evidence="24">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Catalyzes stereospecific hydroxylation of free fatty acids at the C-2 position to produce (R)-2-hydroxy fatty acids, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis. Plays an essential role in the synthesis of galactosphingolipids of the myelin sheath. Responsible for the synthesis of sphingolipids and glycosphingolipids involved in the formation of epidermal lamellar bodies critical for skin permeability barrier. Participates in the synthesis of glycosphingolipids and a fraction of type II wax diesters in sebaceous gland, specifically regulating hair follicle homeostasis. Involved in the synthesis of sphingolipids of plasma membrane rafts, controlling lipid raft mobility and trafficking of raft-associated proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18 19">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="18 19">Binds 2 Zn(2+) ions per subunit that likely form a catalytic dimetal center.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 18">Belongs to the sterol desaturase family. SCS7 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="18"/>
    <dbReference type="EMBL" id="GEZM01088641">
        <property type="protein sequence ID" value="JAV58049.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01088640">
        <property type="protein sequence ID" value="JAV58050.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01088639">
        <property type="protein sequence ID" value="JAV58051.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1KCD3"/>
    <dbReference type="FunCoup" id="A0A1Y1KCD3">
        <property type="interactions" value="48"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1KCD3"/>
    <dbReference type="OrthoDB" id="2204368at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080132">
        <property type="term" value="F:fatty acid 2-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014430">
        <property type="entry name" value="Scs7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12863:SF1">
        <property type="entry name" value="FATTY ACID 2-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12863">
        <property type="entry name" value="FATTY ACID HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005149">
        <property type="entry name" value="IPC-B_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 18" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="17 18" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="10 18" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="6 20" id="KW-0349">Heme</keyword>
    <keyword evidence="14 18 20" id="KW-0408">Iron</keyword>
    <keyword evidence="5 18" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="15 18" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="16 18 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 18 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13 18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11 19" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="241"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="22">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="20">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="20">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRNR" id="PIRNR005149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR005149-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR005149-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="JAV58051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KAB0803087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="328" mass="37701" checksum="8F4811CE796E566E" modified="2017-08-30" version="1">MHKMEENSLIVESNGNHYNVVDFLKNHPGGRNYVEFSKNQDVVSKMEKTHHSKSAFYLLREYKVGGRDEKNNNGEEDLEKLVDWNKPMLCQVGSLGSRYMEWVTSPVDRKLRLFANPLIEGLSITPWYVVPLVWTPIISYMIYCGSLHYIEVTSDPCPIVPVIIFLCLGILIWTLFEYCLHRWVFHIEPSGSSQVLIYVHFAMHGLHHKVPFDSTRLVFPPAPAALIGAVSYNVLKLVLPSSIKLLVFGGGLLGYVIYDMIHFYLHYGAPEEGTILYTMKRHHNQHHFARHDKGFGISNLFWDRIFGTLILLRKLAFGIKWGKPIKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1KHU6</accession>
    <name>A0A1Y1KHU6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PPYR_04434</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01083921">
        <property type="protein sequence ID" value="JAV60944.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1KHU6"/>
    <dbReference type="OrthoDB" id="18814at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005542">
        <property type="term" value="F:folic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090482">
        <property type="term" value="F:vitamin transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000298">
        <property type="entry name" value="Thiamine transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002666">
        <property type="entry name" value="Folate_carrier"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00806">
        <property type="entry name" value="rfc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10686">
        <property type="entry name" value="FOLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10686:SF18">
        <property type="entry name" value="IP11787P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01770">
        <property type="entry name" value="Folate_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Folate_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0290">Folate-binding</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="229"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="267"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="292"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="316"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="351"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="388"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR028739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="JAV60944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0802248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="421" mass="47455" checksum="272F714E401941F2" modified="2017-08-30" version="1">MKEWLKISILLCVFGFLKEIRPSEPFIYEYLIGPWWNNTEEQVTQQVYPVGTYAQLAQLAIVFLITDLCRYKPLIVLMGLSGITAWGMLLWGKTLFHLQVLEVIYGTFMATEVAYYTYIYAKVPKEYYSQVTGHTRAAILAGRCLSGVLAQLLVTLSWMDYRELNYITFSVMIAASVWSISLPSVKMSIYFHRTPEKELLTAREKYQSAFSLMKTHFVESFSNRYVAKWSIWWALATCGFALVQSYMQPLWTVIHTDPNSVLHNGSVEAVLTLIGCFGALSISFIKADWSQRGELVLSLCSILAGALLIISSQTNYILVSYVCYVVFGGLYHFMITIASSEVAKHILEDSYGLVFGLNTLIALVLQTIITVCLISGDIGVALPPRPLHLAFGIYHMGIAVIFIIIGIIDWLKSHADINKTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1KKG9</accession>
    <name>A0A1Y1KKG9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Vacuolar protein sorting-associated protein 72 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PPYR_03827</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS72/YL1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01083912">
        <property type="protein sequence ID" value="JAV60951.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0801641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1KKG9"/>
    <dbReference type="FunCoup" id="A0A1Y1KKG9">
        <property type="interactions" value="2102"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1KKG9"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013272">
        <property type="entry name" value="Vps72/YL1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046757">
        <property type="entry name" value="YL1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13275:SF4">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 72 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13275">
        <property type="entry name" value="YL-1 PROTEIN TRANSCRIPTION FACTOR-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05764">
        <property type="entry name" value="YL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08265">
        <property type="entry name" value="YL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00993">
        <property type="entry name" value="YL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vps72/YL1 C-terminal" evidence="4">
        <location>
            <begin position="271"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="35"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="41"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="128"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="144"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="JAV60951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0801641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="346" mass="40728" checksum="133AAB33165CD666" modified="2017-08-30" version="1">MRDRAKRSTAGNRMAKLLNEEEECQDEFYKVNYGGFQETATDNEYEAEEEGEDQVDSDFSIDENDEPVSENEEESQRKKRRLVTKAYKEPVPNQNKQKSTPKPKPSASKENNDTQQTSDQGERKSIRKSTAAKSAATAQRVKIRTLEQKKKAKKPKEEEWIPTQEELLEEAKVTELENLQALERYQKMESEKKSRRPFKRTRFGPIIRYHSMRMPLIEEVNPEEKVKNENKADPAQKYYERTFITFLDDPNDVVYKNVMKIRPPPKVPNKLRCTITKKPAKYVDPLTCLPYHDIQSFNLIREAYYQQLEAHGDKNDPVMGKWLEWYAKNKDKSRKLRFHRSVPKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1KLJ8</accession>
    <name>A0A1Y1KLJ8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerases I, II, and III subunit RPABC1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">RPB5 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PPYR_01691</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, RPB5 is part of the lower jaw surrounding the central large cleft and thought to grab the incoming DNA template. Seems to be the major component in this process.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes consisting of at least 13, 12 and 17 subunits, respectively. In RNA Pol II, this subunit is present in 2-fold molar excess over the other subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01080240">
        <property type="protein sequence ID" value="JAV62279.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1KLJ8"/>
    <dbReference type="FunCoup" id="A0A1Y1KLJ8">
        <property type="interactions" value="1877"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1KLJ8"/>
    <dbReference type="OrthoDB" id="248779at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1340.10:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerases I, II, and III subunit RPABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.940.20:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerases I, II, and III subunit RPABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1340.10">
        <property type="entry name" value="RNA polymerase, Rpb5, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.940.20">
        <property type="entry name" value="RPB5-like RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00025">
        <property type="entry name" value="RNApol_Rpo5_RPB5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014381">
        <property type="entry name" value="Arch_Rpo5/euc_Rpb5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005571">
        <property type="entry name" value="RNA_pol_Rpb5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036710">
        <property type="entry name" value="RNA_pol_Rpb5_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000783">
        <property type="entry name" value="RNA_pol_subH/Rpb5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020608">
        <property type="entry name" value="RNA_pol_subH/Rpb5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035913">
        <property type="entry name" value="RPB5-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10535">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10535:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01191">
        <property type="entry name" value="RNA_pol_Rpb5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03871">
        <property type="entry name" value="RNA_pol_Rpb5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000747">
        <property type="entry name" value="RPB5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53036">
        <property type="entry name" value="Eukaryotic RPB5 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55287">
        <property type="entry name" value="RPB5-like RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01110">
        <property type="entry name" value="RNA_POL_H_23KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase Rpb5 N-terminal" evidence="11">
        <location>
            <begin position="4"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase subunit H/Rpb5 C-terminal" evidence="10">
        <location>
            <begin position="137"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00060082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00064429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="JAV62279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAB0804721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="210" mass="24591" checksum="0DBB4B1469836617" modified="2017-08-30" version="1">MDDEAETYKLWRIRKTVMQLCHDRGYLVTQDELDQTLEQFKEQFGDKPSEKRPSRTELTVLVAHNDDPTDQMFVFFPDEPKIGIKTIKTYCQRMQDENIHRAIIVVQQGMTPSAKQSLVDMAPKYILEQFLESELLINITEHELVPEHVVMTPEEKQELLARYKLKENMLMRIQAGDPVARYFGLKRGQVVKIIRPSETAGRYISYRLVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1KQN6</accession>
    <name>A0A1Y1KQN6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ARF7 effector protein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_01929</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01076653">
        <property type="protein sequence ID" value="JAV63723.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1KQN6"/>
    <dbReference type="InParanoid" id="A0A1Y1KQN6"/>
    <dbReference type="OrthoDB" id="5984406at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029264">
        <property type="entry name" value="ARF7EP_C"/>
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    </dbReference>
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    </dbReference>
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            <begin position="59"/>
            <end position="153"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="JAV63723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0804959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="166" mass="18781" checksum="F3453E5D54032210" modified="2017-08-30" version="1">MSSDKNVVELDSDNSDEERRKPAPAPVVEKRIAKKSTATSVVDIKQTAAVTRRQVALANKEKQDRFLENFDPESSARERRKLTRKVNQIIPTRRIPGALFDEYGVHIVSGVDLCDCLQKSCPGCHFPCPKCKSQKCGPECRCNRKYIYDQIEYHGCDLVVKNPLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1KR18</accession>
    <name>A0A1Y1KR18_PHOPY</name>
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        <recommendedName>
            <fullName evidence="3">dynamin GTPase</fullName>
            <ecNumber evidence="3">3.6.5.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PPYR_09712</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">1611_PpyrPB1</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">1611_PpyrPB1</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.5" evidence="3"/>
    <dbReference type="EMBL" id="GEZM01078088">
        <property type="protein sequence ID" value="JAV63017.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01078087">
        <property type="protein sequence ID" value="JAV63018.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1KR18"/>
    <dbReference type="FunCoup" id="A0A1Y1KR18">
        <property type="interactions" value="2685"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1KR18"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1240:FF:000001">
        <property type="entry name" value="Dynamin 1 like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000172">
        <property type="entry name" value="Dynamin-1-like protein isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1240">
        <property type="entry name" value="Dynamin, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019762">
        <property type="entry name" value="Dynamin_GTPase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003130">
        <property type="entry name" value="GED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF21">
        <property type="entry name" value="DYNAMIN RELATED PROTEIN 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02212">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00302">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00410">
        <property type="entry name" value="G_DYNAMIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="5 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="16">
        <location>
            <begin position="22"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="15">
        <location>
            <begin position="619"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="513"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="531"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="JAV63018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAB0798719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="711" mass="80294" checksum="6B2D2720718F7717" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1KW65</accession>
    <name>A0A1Y1KW65_PHOPY</name>
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        <recommendedName>
            <fullName evidence="2">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_14204</name>
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    <organism evidence="3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01074888">
        <property type="protein sequence ID" value="JAV64420.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:monoacylglycerol lipase activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:phosphatidylserine catabolic process"/>
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        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277">
        <property type="entry name" value="ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277:SF194">
        <property type="entry name" value="FI04476P"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="alpha/beta-Hydrolases"/>
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    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="143"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="JAV64420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0792245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="374" mass="43057" checksum="62745E0C1988699A" modified="2017-08-30" version="1">MPRPPSNRTTEAPLLKYKTRRKTKSTCIVRCCVISLITMTILLLIAFVVIFVAIPLIFKYSVELQRDLIFPIHELYPENADFNNFTKYDVYGGRNLYVPVNESHNITLGVWHLLPLALVNSSTQEIEFNYTEALEGPDYPVVLHFHGNGGNRINGVEIYSVLREFFHVIAFDYRCYGDSSCGELIEDCLISDAVALYRWLMARTTADIYIWGHSLGSAVGTHAVAELKKENITPAGLFLEAPFTTLRDEVKYVQTLFWFTRAFLWLPWYETTLVDPFEEHGWRFNTVEHLQSVDCPVMIFHSEDDSVIPIRFGRELHETATAVRNHTYQGEVSFQAVPALGFDHWQIYAYDKLPSCIVSHIDVCRVFKEERINV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1L090</accession>
    <name>A0A1Y1L090_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">USP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_06364</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01068231">
        <property type="protein sequence ID" value="JAV67073.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000004">
        <property type="protein sequence ID" value="KAB0800624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1L090"/>
    <dbReference type="FunCoup" id="A0A1Y1L090">
        <property type="interactions" value="1507"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1L090"/>
    <dbReference type="OrthoDB" id="10062454at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
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        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF905">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="3">
        <location>
            <begin position="74"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="265"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="132"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="268"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="JAV67073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0800624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="619" mass="70024" checksum="3C045D646354365A" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1L2V6</accession>
    <name>A0A1Y1L2V6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PPYR_13261</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GEZM01066384">
        <property type="protein sequence ID" value="JAV67912.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01066383">
        <property type="protein sequence ID" value="JAV67914.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1L2V6"/>
    <dbReference type="InParanoid" id="A0A1Y1L2V6"/>
    <dbReference type="OrthoDB" id="6818694at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000218">
        <property type="entry name" value="facilitated trehalose transporter Tret1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050549">
        <property type="entry name" value="MFS_Trehalose_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021:SF46">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="57"/>
            <end position="77"/>
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</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1L7I3</accession>
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        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
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            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
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    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
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                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
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            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="22 23" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
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            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="22">1611_PpyrPB1</strain>
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    <reference evidence="22" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
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    </reference>
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            <text>cytidine + ATP = CMP + ADP + H(+)</text>
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            <text>uridine + ATP = UMP + ADP + H(+)</text>
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        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="17">Pyrimidine metabolism; CTP biosynthesis via salvage pathway; CTP from cytidine: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 17">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uridine: step 1/1.</text>
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    <comment type="subunit">
        <text evidence="16">Interacts with RNF19B.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
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        <text evidence="4 17">Belongs to the uridine kinase family.</text>
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        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="URIDINE KINASE"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Phosphoribulokinase/uridine kinase" evidence="19">
        <location>
            <begin position="120"/>
            <end position="308"/>
        </location>
    </feature>
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            <end position="552"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="18">
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        </location>
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            <begin position="9"/>
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        </location>
    </feature>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF14681"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="JAV67905.1"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAB0796084.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="557" mass="62457" checksum="5CC65ACBC522681F" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LBA7</accession>
    <name>A0A1Y1LBA7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Elongation factor 1-alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PPYR_08871</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pterygota</taxon>
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            <taxon>Endopterygota</taxon>
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            <taxon>Elateroidea</taxon>
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    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
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                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01060739">
        <property type="protein sequence ID" value="JAV70939.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1LBA7"/>
    <dbReference type="InParanoid" id="A0A1Y1LBA7"/>
    <dbReference type="OrthoDB" id="342024at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01883">
        <property type="entry name" value="EF1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03693">
        <property type="entry name" value="EF1_alpha_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03705">
        <property type="entry name" value="EF1_alpha_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000003">
        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000005">
        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000090">
        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00118_A">
        <property type="entry name" value="EF_Tu_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054696">
        <property type="entry name" value="GTP-eEF1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004539">
        <property type="entry name" value="Transl_elong_EF1A_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00483">
        <property type="entry name" value="EF-1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008969">
        <property type="entry name" value="PRK12317.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22594">
        <property type="entry name" value="GTP-eEF1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="9 10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="11">
        <location>
            <begin position="5"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="JAV70939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAB0797878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="461" mass="50482" checksum="7ED879D92854FA7F" modified="2017-08-30" version="1">MGKEKVHINIVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAQEMGKGSFKYAWVLDKLKAERERGITIDIALWKFETAKYYVTIIDAPGHRDFIKNMITGTSQADCAVLIVAAGTGEFEAGISKNGQTREHALLAFTLGVKQLVVGVNKMDSTEPPYSETRFEEIKKEVSSYIKKIGYNPASVAFVPISGWHGDNMLELSDKMPWFKGWNIERKEGKADGKTLIEALDAIMQPSRPTDKPLRLPLQDVYKIGGIGTVPVGRVETGILKPGMVVTFAPVGLTTEVKSVEMHHEALQEAVPGDNVGFNVKNVSVKELKRGFVAGDSKNNPPRGVSDFTAQVIVLNHPGQIANGYTPVLDCHTAHIACKFAEIKEKCDRRTGKTTEENPKAIKSGDAAIVNLVPSKPMCVESFQEYPPLGRFAVRDMRQTVAVGVIKSVSFKDTAGKVTKAAEKAQKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LJP7</accession>
    <name>A0A1Y1LJP7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PPYR_12801</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">1611_PpyrPB1</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">1611_PpyrPB1</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01054067">
        <property type="protein sequence ID" value="JAV73863.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1LJP7"/>
    <dbReference type="FunCoup" id="A0A1Y1LJP7">
        <property type="interactions" value="66"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1LJP7"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11056">
        <property type="entry name" value="CYP6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000042">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050476">
        <property type="entry name" value="Insect_CytP450_Detox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292:SF54">
        <property type="entry name" value="CYP9F3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0492">Microsome</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="473"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
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            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
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        <property type="entry name" value="PROTEIN N-TERMINAL ASPARAGINE AMIDOHYDROLASE"/>
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        <property type="entry name" value="N_Asn_amidohyd"/>
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        <source>
            <dbReference type="EMBL" id="JAV75651.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAB0796480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="310" mass="34804" checksum="CF15784E9C32ACA4" modified="2017-08-30" version="1">MVLVLNGVLQEDCPQDTRSLYHTHPVYRETAAQLLAIPNKIIGPVGLLYVQQREFAATVPHDKNVSILGSDDATTCIIVVLRHSGSGAVALAHFDGSGTDEAVCTMVQRVQDLSVGYQEGRIELQLVGGFSDAHNYSEDIFFNIMNCFHKLPVEIDLTLACVGELNTTVRGGIHWPMVYGAGVNIKTGEIFPATFPDKGPDQALRRARHLTGQAQVLEIYESHLGLLRIGPFNYEPLRGVDLWLEQSDEFILQHLSTSPEVEPPHFVMQIRATLKYIQDNQFPAVTVFRENRPHYFRRDEHSGTWQPIRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LTJ6</accession>
    <name>A0A1Y1LTJ6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UBX domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="7" type="ORF">PPYR_11919</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
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        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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    </organism>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
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                <person name="Al-Wathiqui N."/>
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                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
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        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
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        </source>
    </reference>
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        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
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        </source>
    </reference>
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    </comment>
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        <property type="term" value="C:endoplasmic reticulum"/>
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    </dbReference>
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        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
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    <sequence length="448" mass="51662" checksum="F0515D621C8EAAE0" modified="2017-08-30" version="1">MDYLGDNGGLGLTSEQTEKVLQFQDLTGIEDMSICRDVLQRHQWNLEVAVQEQLNIREGRPSLYATETRPPAVVSDHLGQHVFYTPPTDGSGSGIRGFFANIINFFWTLCYNTIITFLQIGRRVIGTDSRNALTNPIEDVLDFIRVYEEKYSSVHPVFYQGTYSQVLNDAKHELKFLLIYLHSDNAIDTLAFCRDTLSQPDVVTYINTNFLFWGCSSKSGEGYKVSQLFRPKHYPYMAVVVLKDNRMTIVSRMEGYCDSNVLLHRLTTVVAEFEINLVQARTDRVEASLNRSLRAHQDEAFLESLRADQEKERRRREEREAEQAELRRMEQEARAEQERRQSIAQEKINSVTKVPSEPDANHPDAVHVVFKLPSGHRLERRFLKSHSLEAIFYFVFCHPAAPDTFEITTNFPKKVLYCVPQHESDYVQTLEEAGLQHREVLFINDLDA</sequence>
</entry>
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    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
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            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
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    <reference evidence="9" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
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        <subcellularLocation>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
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    <dbReference type="InterPro" id="IPR000301">
        <property type="entry name" value="Tetraspanin_animals"/>
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    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282:SF252">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00335">
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        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00259">
        <property type="entry name" value="TMFOUR"/>
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    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="59"/>
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        <source>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
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                <person name="Bessho-Uehara M."/>
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                <person name="Bewick A.J."/>
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                <person name="Debat H.J."/>
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                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
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                <person name="Weng J.K."/>
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                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
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        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
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                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
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                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
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        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
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            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="9">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the histone H2A family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01040178">
        <property type="protein sequence ID" value="JAV80942.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000004">
        <property type="protein sequence ID" value="KAB0800580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1M590"/>
    <dbReference type="FunCoup" id="A0A1Y1M590">
        <property type="interactions" value="1766"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1M590"/>
    <dbReference type="OrthoDB" id="9421954at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000005">
        <property type="entry name" value="Histone H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032458">
        <property type="entry name" value="Histone_H2A_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00046">
        <property type="entry name" value="HISTONE_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8 9" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="11">
        <location>
            <begin position="10"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="Histone H2A C-terminal" evidence="12">
        <location>
            <begin position="95"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="JAV80942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAB0800580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="129" mass="13500" checksum="ED6457F102A7FA4E" modified="2017-08-30" version="1">MAGGKAGKDSGKAKAKAVSRSARAGLQFPVGRIHRHLKNRTTSHGRVGATAAVYSAAILEYLTAEVLELAGNASKDLKVKRITPRHLQLAIRGDEELDSLIKATIAGGGVIPHIHKSLIGKKGAHSQPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1M6P4</accession>
    <name>A0A1Y1M6P4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_01497</name>
        <name evidence="10" type="ORF">PPYR_02673</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="GEZM01038785">
        <property type="protein sequence ID" value="JAV81509.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0805703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1M6P4"/>
    <dbReference type="FunCoup" id="A0A1Y1M6P4">
        <property type="interactions" value="1283"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1M6P4"/>
    <dbReference type="OrthoDB" id="2687620at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="29"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="328"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="334"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="374"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="397"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="423"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="JAV81509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0804527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0805703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="452" mass="50607" checksum="A1B2A86385AC68E8" modified="2017-08-30" version="1">MPPKAKNGYKLPAPLPLNLVVEDVNRNKWKLGPSIGKGGFGEIYSAKDASSSGSSFPYVVKIEPHKNGPLFVEMHFYMRNGKEDQIQEFKVKKKLASLGMPKYIASGSHEHNGEKYRFVVMEKFGSDIWKIFLENDRRFSPDIVFKLGVQILDVLEYIHSQGYIHADIKGPNILLGPDAESDSQVYLVDFGLCSHYSASEKPDPKKAHNGTIEYVSRDGHLGIESRRGDLECLGYNLVQWLGCALPWEVDLSDPKIVQQSKIDNMKNLTTFFKKCFSDGKPPGAISEYMKYVSTLKFGIDPDYGKLRKILVKGVEAAGGSMKAPFGFKTSKSSPAKRKIAAKSPTPKKKTKVVAKKTKATKTAKPVAENREKDVEEDNEVNVENGQEAEDNMVGYTDEMKNIKKKLDEKKKKAVKPVSVAEPRPLRVRKEINYSDNSPKDNPKRTATTKKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1MED4</accession>
    <name>A0A1Y1MED4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein CNPPD1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_11198</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CNPPD1 family.</text>
    </comment>
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        <property type="protein sequence ID" value="JAV82685.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0794359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:nucleus"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PROTEIN CNPPD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="207"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00040808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="JAV82685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0794359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="421" mass="48344" checksum="72DAD1EC54C25B7C" modified="2017-08-30" version="1">MSKISKKSKEKKFKSIGNHQQFLERITKSLYYGKLPSTECLSLPVTELASELFSEAQTGRSLDRLHCNDAAKISRNACVSPCSFVLAVLYLEQLKSCNPEYLYRVAPSELFLISLMVSSKFLHDDGEEDEVFIEEWAQSARISTKELAQLEMNFLAAIDWKVFVHEHAFWKKLADIESMIAKRQGTTRGWYTYYELEKIMAMNVSHLLQSITVTLSVLIATYALGILTILGSVFIVSNIPGNCLQSRTVYMKAENYDSRILDEVDNNTHIILNSFPSDLAEYTRRKHMDAVDILKTSILLATLTSETDSKNETEPVPSSINPPANVTKHSWAWWLSPTMDWLTQTSRIIEKFDFIPEIKSFTYDTYIDSSFATSKILALENQIHKPTKVRIQDQLERSWHKEWTDTFRNVILQYKLLSVCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1MJT2</accession>
    <name>A0A1Y1MJT2_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Archease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_03321</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the archease family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01030905">
        <property type="protein sequence ID" value="JAV85189.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01030902">
        <property type="protein sequence ID" value="JAV85198.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01030890">
        <property type="protein sequence ID" value="JAV85224.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01030883">
        <property type="protein sequence ID" value="JAV85242.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01030880">
        <property type="protein sequence ID" value="JAV85251.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1MJT2"/>
    <dbReference type="FunCoup" id="A0A1Y1MJT2">
        <property type="interactions" value="58"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1MJT2"/>
    <dbReference type="OrthoDB" id="2190767at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072669">
        <property type="term" value="C:tRNA-splicing ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="protein archease isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.10.10">
        <property type="entry name" value="Archease domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <dbReference type="InterPro" id="IPR023572">
        <property type="entry name" value="Archease_dom"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12682:SF11">
        <property type="entry name" value="PROTEIN ARCHEASE"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF01951">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MTH1598-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Archease" evidence="5">
        <location>
            <begin position="15"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="JAV85198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0791521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="156" mass="17801" checksum="0797210734EFF598" modified="2017-08-30" version="1">MDLEHEDLTLAPCKYEYLDHTADVQLHAWGDTLKEAFEQCGMAMFGYMTTLSTVEIRDVHTIEASGHDLESLLFHFLDELLFLFSCDPFLICSKLVITEFKTEGEELSVSCKCYGEEFTLGKHPQGTEVKAITYSAMQIVAEPERNEYEVFVIIDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1MLH5</accession>
    <name>A0A1Y1MLH5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">E3 UFM1-protein ligase 1 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">E3 UFM1-protein transferase 1 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PPYR_05107</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">E3 UFM1-protein ligase that mediates ufmylation of target proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UFL1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01028002">
        <property type="protein sequence ID" value="JAV86529.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1MLH5"/>
    <dbReference type="FunCoup" id="A0A1Y1MLH5">
        <property type="interactions" value="2427"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1MLH5"/>
    <dbReference type="OrthoDB" id="10258297at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061666">
        <property type="term" value="F:UFM1 ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="P:protein K69-linked ufmylation"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:response to endoplasmic reticulum stress"/>
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    </dbReference>
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        <property type="entry name" value="Ufl1"/>
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        <property type="entry name" value="Ufl1_dom"/>
    </dbReference>
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        <property type="entry name" value="Ufl1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31057">
        <property type="entry name" value="E3 UFM1-PROTEIN LIGASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31057:SF0">
        <property type="entry name" value="E3 UFM1-PROTEIN LIGASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09743">
        <property type="entry name" value="E3_UFM1_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23659">
        <property type="entry name" value="UFL1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UFL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25870">
        <property type="entry name" value="WHD_UFL1_5th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
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        <location>
            <begin position="6"/>
            <end position="279"/>
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        <location>
            <begin position="528"/>
            <end position="645"/>
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        <location>
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        <location>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00014160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF25041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="JAV86529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAB0802921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="764" mass="86646" checksum="465C383B2CEBA45E" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1MM98</accession>
    <name>A0A1Y1MM98_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">[heparan sulfate]-glucosamine N-sulfotransferase</fullName>
            <ecNumber evidence="5">2.8.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">PPYR_09006</name>
    </gene>
    <organism evidence="22">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="23 24" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">1611_PpyrPB1</strain>
            <tissue evidence="23">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">1611_PpyrPB1</strain>
            <tissue evidence="23">Whole body</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Glycan metabolism; heparan sulfate biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; heparin biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the sulfotransferase 1 family. NDST subfamily.</text>
    </comment>
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    <dbReference type="EMBL" id="GEZM01030073">
        <property type="protein sequence ID" value="JAV85819.1"/>
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    </dbReference>
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    </dbReference>
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        <property type="protein sequence ID" value="KAB0798013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:deacetylase activity"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:heparan sulfate N-sulfotransferase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="term" value="F:hydrolase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015012">
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        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
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        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
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        <property type="entry name" value="bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1"/>
        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="Heparan_SO4_deacetylase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056793">
        <property type="entry name" value="HSNSD_N"/>
    </dbReference>
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        <property type="entry name" value="NST/OST"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10605:SF56">
        <property type="entry name" value="BIFUNCTIONAL HEPARAN SULFATE N-DEACETYLASE_N-SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HEPARAN SULFATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12062">
        <property type="entry name" value="HSNSD-CE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25119">
        <property type="entry name" value="HSNSD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 18" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
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    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Heparan sulfate-N-deacetylase N-terminal" evidence="21">
        <location>
            <begin position="114"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="Heparan sulphate-N-deacetylase deacetylase" evidence="20">
        <location>
            <begin position="334"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfotransferase" evidence="19">
        <location>
            <begin position="628"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="active site" description="For sulfotransferase activity" evidence="16">
        <location>
            <position position="637"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="735"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="840"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="856"/>
            <end position="860"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="841"/>
            <end position="851"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR637359-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR637359-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR637359-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF12062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF25119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="JAV85820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KAB0798013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="907" mass="105507" checksum="8DF9229A2D2A4D23" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1MMA7</accession>
    <name>A0A1Y1MMA7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">diacylglycerol cholinephosphotransferase</fullName>
            <ecNumber evidence="13">2.7.8.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PPYR_07480</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">1611_PpyrPB1</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">1611_PpyrPB1</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>1,2-dioctanoyl-sn-glycerol + CDP-choline = 1,2-dioctanoyl-sn-glycero-3-phosphocholine + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54232"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58779"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:76979"/>
            <dbReference type="ChEBI" id="CHEBI:78228"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:54233"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + CDP-choline = 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54332"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58779"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:74963"/>
            <dbReference type="ChEBI" id="CHEBI:82949"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:54333"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CDP-choline = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54244"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58779"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:73001"/>
            <dbReference type="ChEBI" id="CHEBI:75466"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:54245"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>CDP-choline + a 1,2-diacyl-sn-glycerol = a 1,2-diacyl-sn-glycero-3-phosphocholine + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32939"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58779"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:32940"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="12">Phospholipid metabolism; phosphatidylcholine biosynthesis; phosphatidylcholine from phosphocholine: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.2" evidence="13"/>
    <dbReference type="EMBL" id="GEZM01030033">
        <property type="protein sequence ID" value="JAV85830.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1MMA7"/>
    <dbReference type="FunCoup" id="A0A1Y1MMA7">
        <property type="interactions" value="1662"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1MMA7"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004142">
        <property type="term" value="F:diacylglycerol cholinephosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004307">
        <property type="term" value="F:ethanolaminephosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1760:FF:000002">
        <property type="entry name" value="Choline/ethanolamine phosphotransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014472">
        <property type="entry name" value="CHOPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414:SF37">
        <property type="entry name" value="BB IN A BOXCAR, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414">
        <property type="entry name" value="ETHANOLAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015665">
        <property type="entry name" value="CHOPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="248"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="283"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00036100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00036651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00036890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="JAV85830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAB0799600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="412" mass="46396" checksum="D82E79F20CEE578A" modified="2017-08-30" version="1">MQLYKQKLLSNAQLKRLSEHRYSCSSSSLLDIVLQPYWTWLVEKLPIWLAPNLITIVGLFINVITTLILVWYAPDAKTEAPRWTCLLCAVGLFVYQSLDAIDGKQARRTNTATPLGELFDHGCDSISTVFVALSTCISIQLGHYPHWMFFQCFCAMTLFYCAHWQTYVSGTLRFGRIDVTEAQITIILIQLVSTIFGPNIWSTKVFSEMFVLWYFIPISTIICGVWALSNNLTIIFTGGIGKNGSTVAGTSVLSPIIPFATVLVPAVTIYCKSIQNVYELNPALYIIAFGMVAAKVTNRLVVAHMTKSEMEYMDWSLIGPAMLFLNQYFNTYIPEYIVLWLCLLWATFDLIRYCTQICSEICDHLHIELFSITRVGRTAVAASSMPPTEKNGSITHSGHEDTLPLIEYCSDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1MZA5</accession>
    <name>A0A1Y1MZA5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
            <ecNumber evidence="6">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">PPYR_06759</name>
    </gene>
    <organism evidence="21">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="22 23" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">1611_PpyrPB1</strain>
            <tissue evidence="22">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">1611_PpyrPB1</strain>
            <tissue evidence="22">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Transfers mannosyl residues to the hydroxyl group of serine or threonine residues.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TMTC family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="6"/>
    <dbReference type="EMBL" id="GEZM01016975">
        <property type="protein sequence ID" value="JAV90999.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01016974">
        <property type="protein sequence ID" value="JAV91000.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01016972">
        <property type="protein sequence ID" value="JAV91002.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0798879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1MZA5"/>
    <dbReference type="FunCoup" id="A0A1Y1MZA5">
        <property type="interactions" value="1054"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1MZA5"/>
    <dbReference type="OrthoDB" id="66906at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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                <person name="Bessho-Uehara M."/>
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                <person name="Debat H.J."/>
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                <person name="Day J.C."/>
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                <person name="Silva C.J."/>
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                <person name="Shigenobu S."/>
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                <person name="Bessho-Uehara M."/>
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                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
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                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
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                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
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                <person name="Oba Y."/>
                <person name="Weng J.K."/>
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            <dbReference type="PubMed" id="30324905"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Bessho-Uehara M."/>
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                <person name="Schmitz R.J."/>
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                <person name="Shigenobu S."/>
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                <person name="Sander Lower S.E."/>
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        <source>
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        <source>
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        <source>
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    </evidence>
    <sequence length="867" mass="99770" checksum="EAFF669328C834E3" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
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        <name evidence="9" type="ORF">PPYR_14459</name>
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        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
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    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
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                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
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    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="9">1611_PpyrPB1</strain>
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        </source>
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</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
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                <person name="Weng J.K."/>
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            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
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                <person name="Weng J.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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            <tissue evidence="8">Whole body</tissue>
        </source>
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    </dbReference>
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        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="JAV97254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0800313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="223" mass="24539" checksum="B48E7999AB708C06" modified="2017-08-30" version="1">MDKTVENEWKPNEDLLRMLMEMGIAKIAAEHALFYTGNNSAEAAASYVFDNFENDEASTPPLTSLLKTQLYEIDGTDGSPRRNPSGEVVDSGDEEDAAEGLLDPETSYKMVFVVNSSLNMGVGKLAAQVAHASLGLYRTLIEFHTMEQAVDKWTNEGEKKVVLKGENHIHLQELQKQAEFSNIHSYLVHDAGRTQIPPNSVTVLGLFGEEKIVNSVTGNLSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N3ZYC9</accession>
    <name>A0A5N3ZYC9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_15624</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01001991">
        <property type="protein sequence ID" value="KAB0790061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N3ZYC9"/>
    <dbReference type="InParanoid" id="A0A5N3ZYC9"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF71">
        <property type="entry name" value="ZINC FINGER PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13384">
        <property type="entry name" value="HTH_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="4">
        <location>
            <begin position="63"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="428"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="490"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="428"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0790061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="639" mass="72538" checksum="D3AADF710BF1D966" modified="2020-02-26" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N3ZZ06</accession>
    <name>A0A5N3ZZ06_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_15379</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01001566">
        <property type="protein sequence ID" value="KAB0790279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N3ZZ06"/>
    <dbReference type="InParanoid" id="A0A5N3ZZ06"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006621">
        <property type="entry name" value="Nose-resist-to-fluoxetine_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052728">
        <property type="entry name" value="O2_lipid_transport_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161">
        <property type="entry name" value="O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161:SF0">
        <property type="entry name" value="O-ACYLTRANSFERASE LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20146">
        <property type="entry name" value="NRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00180">
        <property type="entry name" value="CRETINALDHBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="367"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="424"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="475"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="513"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="573"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="600"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="639"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="675"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="712"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="736"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="787"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="141"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0790279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="883" mass="100198" checksum="A40E3AE41F7DF059" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N3ZZ67</accession>
    <name>A0A5N3ZZ67_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Fasciclin 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PPYR_15341</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01001505">
        <property type="protein sequence ID" value="KAB0790318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N3ZZ67"/>
    <dbReference type="FunCoup" id="A0A5N3ZZ67">
        <property type="interactions" value="338"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N3ZZ67"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
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        <property type="term" value="P:cell adhesion"/>
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        <property type="term" value="P:cell differentiation"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Myosin, light chain kinase a"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="7"/>
    </dbReference>
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        <property type="entry name" value="FN3_dom"/>
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        <property type="entry name" value="FN3_sf"/>
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        <property type="entry name" value="Ig-like_dom"/>
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        <property type="entry name" value="Ig-like_dom_sf"/>
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        <property type="entry name" value="Ig-like_fold"/>
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        <property type="entry name" value="Ig_I-set"/>
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        <property type="entry name" value="Ig_sub"/>
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        <property type="entry name" value="Ig_sub2"/>
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        <property type="entry name" value="Neural/epithelial_adhesion"/>
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        <property type="entry name" value="Neural_cell_adh"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231">
        <property type="entry name" value="CTX-RELATED TYPE I TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231:SF269">
        <property type="entry name" value="FASCILIN 2-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
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        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01838">
        <property type="entry name" value="NCAMFAMILY"/>
    </dbReference>
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        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="IG"/>
        <property type="match status" value="5"/>
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        <property type="entry name" value="IGc2"/>
        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="4"/>
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        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="7"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="126"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="205"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="297"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="402"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="12">
        <location>
            <begin position="499"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="12">
        <location>
            <begin position="619"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAB0790318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="733" mass="82958" checksum="D5F6822BBE46CD3D" modified="2020-02-26" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A0L5</accession>
    <name>A0A5N4A0L5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">mannose-6-phosphate isomerase</fullName>
            <ecNumber evidence="4">5.3.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Phosphohexomutase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Phosphomannose isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PPYR_14951</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">1611_PpyrPB1</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-mannose 6-phosphate = D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:12356"/>
            <dbReference type="ChEBI" id="CHEBI:58735"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="5.3.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the mannose-6-phosphate isomerase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.8" evidence="4"/>
    <dbReference type="EMBL" id="VVIM01000684">
        <property type="protein sequence ID" value="KAB0790864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A0L5"/>
    <dbReference type="FunCoup" id="A0A5N4A0L5">
        <property type="interactions" value="1173"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A0L5"/>
    <dbReference type="OrthoDB" id="6605218at2759"/>
    <dbReference type="UniPathway" id="UPA00126">
        <property type="reaction ID" value="UER00423"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004476">
        <property type="term" value="F:mannose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009298">
        <property type="term" value="P:GDP-mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07011">
        <property type="entry name" value="cupin_PMI_type_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000044">
        <property type="entry name" value="Mannose-6-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.441.10">
        <property type="entry name" value="Phosphomannose Isomerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001250">
        <property type="entry name" value="Man6P_Isoase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016305">
        <property type="entry name" value="Mannose-6-P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018050">
        <property type="entry name" value="Pmannose_isomerase-type1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046456">
        <property type="entry name" value="PMI_typeI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046457">
        <property type="entry name" value="PMI_typeI_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046458">
        <property type="entry name" value="PMI_typeI_hel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00218">
        <property type="entry name" value="manA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10309">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10309:SF0">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01238">
        <property type="entry name" value="PMI_typeI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20511">
        <property type="entry name" value="PMI_typeI_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20512">
        <property type="entry name" value="PMI_typeI_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001480">
        <property type="entry name" value="Mannose-6-phosphate_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00714">
        <property type="entry name" value="MAN6PISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00966">
        <property type="entry name" value="PMI_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Phosphomannose isomerase type I catalytic" evidence="14">
        <location>
            <begin position="2"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphomannose isomerase type I helical insertion" evidence="15">
        <location>
            <begin position="173"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphomannose isomerase type I C-terminal" evidence="13">
        <location>
            <begin position="323"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="281"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001480-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001480-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF20511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF20512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAB0790864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="403" mass="45311" checksum="3D48473932F346EC" modified="2020-02-26" version="1">MELQCEVQTYEWGKLGLDSKVAVLHKLSNPTFEVGEDTPYAELWMGTHRNAPSRVKETGELLSAVIETKPEYLGEPVRLMFGNELPFLLKILSINKALSIQAHPSKEIARELHKSNPEVYKNPNHKPEFAIALTPFEALCGFRPIAEIKEFMKNIRELRAIVGVDISEKFILSDAANEKDMLKTCFRSLMLCPQDVVSAQLKQLLFKFSGRDEKTREEQMAPLLERLYSQFPDDIGCFVVYFLNYVVLQPNEAIYLGANEPHAYLSGDCVECMACSDNIVRAGLTPKYKDVETLCRILTYQTKPAREQLLRPTVEDAYCQAFKPPVPDFAVIKIEVPAAVGDYTLKPRQSASVLIVIGGGGRMGSTRLKAGTVVFIPANEKYEIVDITQDILMFQAMANVDMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A195</accession>
    <name>A0A5N4A195_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PPYR_02895</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A195"/>
    <dbReference type="InParanoid" id="A0A5N4A195"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000218">
        <property type="entry name" value="facilitated trehalose transporter Tret1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050549">
        <property type="entry name" value="MFS_Trehalose_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021:SF46">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="75"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="235"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="315"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="384"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="415"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="454"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="482"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="80"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0791095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="522" mass="58175" checksum="3DB987B2624D70B9" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A2K4</accession>
    <name>A0A5N4A2K4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_03364</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the PP2C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A2K4"/>
    <dbReference type="InParanoid" id="A0A5N4A2K4"/>
    <dbReference type="OrthoDB" id="10025511at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.40.10:FF:000060">
        <property type="entry name" value="Protein phosphatase 2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47992">
        <property type="entry name" value="PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="6">
        <location>
            <begin position="8"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="427"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="512"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="512"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0791564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="570" mass="64183" checksum="D94160ABB2AFE889" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A2N2</accession>
    <name>A0A5N4A2N2_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_03385</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TALE/MEIS homeobox family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A2N2"/>
    <dbReference type="InParanoid" id="A0A5N4A2N2"/>
    <dbReference type="OrthoDB" id="10056939at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000987">
        <property type="term" value="F:cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048646">
        <property type="term" value="P:anatomical structure formation involved in morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001654">
        <property type="term" value="P:eye development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048663">
        <property type="term" value="P:neuron fate commitment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000004">
        <property type="entry name" value="Meis2 homeobox isoform 2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008422">
        <property type="entry name" value="KN_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032453">
        <property type="entry name" value="PKNOX/Meis_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050224">
        <property type="entry name" value="TALE_homeobox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11850">
        <property type="entry name" value="HOMEOBOX PROTEIN TRANSCRIPTION FACTORS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05920">
        <property type="entry name" value="Homeobox_KN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16493">
        <property type="entry name" value="Meis_PKNOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="284"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="286"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="150"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="248"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="351"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="390"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="284"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="354"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="397"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="415"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0791585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="445" mass="48691" checksum="B07D418F2CC28DFC" modified="2020-02-26" version="1">MDCGVQSAMLSVAPGSDAAAQQPLSAAALFPTSEGDQAQFEADKRAVYKHPLFPLLALLFERCELATQSSDPQSSDAFNMDIQAFVQHQERDRKPFLANEPEIDGLMIKAIQVLRIHLLELEKVQELCKDFCNRYITCLKGKMQSENLLRSDYPQGPSVMNNNLESSNNNNSLMSHANSESGSDSNSPVQYTISPQQVIPTPTSVLERQLDTPTNYGVQSYAVPPQAIPPQPACENIVVHGSTPLSQIGVTACPPPPSDSSGQVSPAPTTPGGSEECDSDFTSRGRKQKRGVLPKHATSVMRSWLFQHLVHPYPTEDEKRHIAAQTNLTLLQVNNWFINARRRILQPMLDASAPNDSSATSSPAHKKKKVQNNNRRFWPQDFASMQPQIDSGILSSSDDDGDSYSSDGEEGSLVIDSSAQGGEVNQNGHQLDPLAFDNSPKLERP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A3W2</accession>
    <name>A0A5N4A3W2_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Caspase family p20 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_13952</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C14A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0791991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A3W2"/>
    <dbReference type="InParanoid" id="A0A5N4A3W2"/>
    <dbReference type="OrthoDB" id="6097640at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043525">
        <property type="term" value="P:positive regulation of neuron apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002398">
        <property type="entry name" value="Pept_C14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001309">
        <property type="entry name" value="Pept_C14_p20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015917">
        <property type="entry name" value="Pept_C14A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10454:SF232">
        <property type="entry name" value="AT03047P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10454">
        <property type="entry name" value="CASPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00115">
        <property type="entry name" value="CASc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50208">
        <property type="entry name" value="CASPASE_P20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Caspase family p20" evidence="3">
        <location>
            <begin position="69"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="282"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="291"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="311"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0791991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="320" mass="37089" checksum="2FC3FC1CDB5F6112" modified="2020-02-26" version="1">MFESDGKVVRQKEEKYEIPKHLFHPDDVEEITVPPSTELIPDEYEHRDNSKGLVLIFYSKRDVDNEQVIRREFRDQGYNVSDSNVFGLQSRSAVLEALDQVAKGDHKEKSCLIIFFLGMAEEEGKLELDEDPDSSIELRDVWTKFTSNNCPSLRNKPKIFIFQACRKPTAYAFDSKAMTPQGAYSLPSEADILIVYKVTGYHSRAQFIRSLCNKIDKFGQKDDIIGLVTRTHDHKYIRPLIISTMTRKFYVSSSANRGHYHDLHNNQDETIIQLRNWHNEIKRNNEEKRSAPSSKETSQADLPGSKRKKIPKAEKRPPWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A457</accession>
    <name>A0A5N4A457_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PPYR_14043</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A457"/>
    <dbReference type="InParanoid" id="A0A5N4A457"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001817">
        <property type="term" value="P:regulation of cytokine production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002682">
        <property type="term" value="P:regulation of immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000029">
        <property type="entry name" value="GLI family zinc finger 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002063">
        <property type="entry name" value="RB associated KRAB zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001557">
        <property type="entry name" value="Transcription factor E4F1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000478">
        <property type="entry name" value="Zinc finger protein 133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000902">
        <property type="entry name" value="Zinc finger protein 445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000710">
        <property type="entry name" value="Zinc finger protein 768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001450">
        <property type="entry name" value="zinc finger protein 774"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24399:SF6">
        <property type="entry name" value="MYONEURIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24399">
        <property type="entry name" value="ZINC FINGER AND BTB DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="37"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="65"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="93"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="121"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="149"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="177"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="205"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="233"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAB0792082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="281" mass="31681" checksum="22B41A5FE6FB04D6" modified="2020-02-26" version="1">MVDKPHVCKQCGKGFAESHALTKHTKKHLGQPREKRHLCTICGQRFGEPFYLNIHMRKHTGERPLICATCGKSFADPRSLKAHHMTHTGERPHKCNLCGKAFSQSVNLIKHIRIHTGEKPYVCSECGKCFTQSSSLDKHARTHTGEKPYSCEHCLKRFAEKGTLVHHIRTHTGEKPYVCDQCGKCFASSYELKLHDRKHSGVKANICSACGKDFATKSNLSVHMRTHSGEKPYQCAVCRRAFADNGSLKKHLKVHQSVPIQTLPDPCVEIGLNERLYFNLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A6I0</accession>
    <name>A0A5N4A6I0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PPYR_12545</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">1611_PpyrPB1</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Unusual broad substrate spectrum amino acid:sodium cotransporter that promotes absorption of the D isomers of essential amino acids. Neutral amino acids are the preferred substrates, especially methionine and phenylalanine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0792925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A6I0"/>
    <dbReference type="FunCoup" id="A0A5N4A6I0">
        <property type="interactions" value="24"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A6I0"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005283">
        <property type="term" value="F:amino acid:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0089718">
        <property type="term" value="P:amino acid import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10324">
        <property type="entry name" value="SLC6sbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF037979">
        <property type="entry name" value="Na_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF321">
        <property type="entry name" value="SODIUM-DEPENDENT NUTRIENT AMINO ACID TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00610">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00754">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 14" id="KW-0915">Sodium</keyword>
    <keyword evidence="12" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 15" id="KW-0769">Symport</keyword>
    <keyword evidence="4 15 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="220"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="250"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="292"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="328"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="389"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="430"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="459"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="500"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="542"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="402"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="406"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAB0792925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="623" mass="69306" checksum="999AC60E71F05EFF" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A6M1</accession>
    <name>A0A5N4A6M1_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PPYR_12581</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0792961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A6M1"/>
    <dbReference type="InParanoid" id="A0A5N4A6M1"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058353">
        <property type="entry name" value="DUF8040"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF269">
        <property type="entry name" value="NUCLEASE HARBI1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26138">
        <property type="entry name" value="DUF8040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF8040" evidence="9">
        <location>
            <begin position="6"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="DDE Tnp4" evidence="8">
        <location>
            <begin position="124"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF26138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0792961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="209" mass="24133" checksum="F587D09035AA0786" modified="2020-02-26" version="1">MTKEFNDEQFKNYFRLNRDQFIEVHEIIKKEIDAEGCTATRPIGTEEKLSVFLRYLATGNSYRSMAYSYRMGDRTVSNIVREVSEAIWKLMQPIYLPQPTEEQWKSVADSFQRKWQFPHCIGAIDGKHVVIKKPGKSGSSYINYKHTFSIVLMAVVDSDYKFITIDVGSQGRFSDGNVFSTGVLAKKLLDHTLHLPAPTEMRPSYYLRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A7J9</accession>
    <name>A0A5N4A7J9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SEC7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_12913</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum-Golgi intermediate compartment</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">cis-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A5N4A7J9">
        <property type="interactions" value="2119"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A7J9"/>
    <dbReference type="OrthoDB" id="10258608at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010256">
        <property type="term" value="P:endomembrane system organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00171">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1000.11:FF:000007">
        <property type="entry name" value="Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056604">
        <property type="entry name" value="GBF1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032691">
        <property type="entry name" value="Mon2/Sec7/BIG1-like_HUS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF388">
        <property type="entry name" value="GOLGI-SPECIFIC BREFELDIN A-RESISTANCE GUANINE NUCLEOTIDE EXCHANGE FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12783">
        <property type="entry name" value="Sec7-like_HUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23325">
        <property type="entry name" value="TPR_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SEC7" evidence="6">
        <location>
            <begin position="646"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="218"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="292"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="328"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1242"/>
            <end position="1304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1396"/>
            <end position="1439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1805"/>
            <end position="1844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="224"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="252"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="342"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1407"/>
            <end position="1416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1429"/>
            <end position="1439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1818"/>
            <end position="1835"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0793293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1905" mass="214149" checksum="4F60E98A544191B3" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2024-10-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A7Z4</accession>
    <name>A0A5N4A7Z4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HORMA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_13045</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A7Z4"/>
    <dbReference type="InParanoid" id="A0A5N4A7Z4"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.10">
        <property type="entry name" value="HORMA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003511">
        <property type="entry name" value="HORMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051294">
        <property type="entry name" value="HORMA_MeioticProgression"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48225">
        <property type="entry name" value="HORMA DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48225:SF7">
        <property type="entry name" value="MEIOSIS-SPECIFIC PROTEIN HOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02301">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56019">
        <property type="entry name" value="The spindle assembly checkpoint protein mad2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50815">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0469">Meiosis</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HORMA" evidence="6">
        <location>
            <begin position="25"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0793425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="431" mass="48877" checksum="94C89105EA6649E9" modified="2020-02-26" version="1">MSSTQHKFSDLLSSSVVHTAVLNPVASRGYLKKVLSAAFATILHKRTTLDAALFRNHNFNGIDYNMFSVTTKSEIVRNFRCWTKGAFHALERNYLQDLYLVFTKVNDPSDVIESYKFKFKYSTDAKASTITDDELDRMTTSLLESINGLDMRELLETDKFSPFVIITYCNDTPRDYQPPFHRNDYLTASTIFKNLSTDGTRLDLGHILTGFHSVKCRAKGKLLVPEEYDTTQSKHTSTVDETAEELDEDDLLTNDEPATREFSNSLNLDCPCNLHKMYCSINTIECYNCKSLKHTPCVQFFSAISDKYLCDQCQNSPALTPRQIVLQQETSVYRLAVVFAYFNRIVPSDVLDSAPPQCKFVVLQKLVKRKILSYDGIKYNLDPNQLDIAALQVFGTDSDTNMICAPESSTLTNYDSNSIIFSGASKKRKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A814</accession>
    <name>A0A5N4A814_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_13072</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A814"/>
    <dbReference type="FunCoup" id="A0A5N4A814">
        <property type="interactions" value="244"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A814"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004090">
        <property type="term" value="F:carbonyl reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050038">
        <property type="term" value="F:L-xylulose reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005997">
        <property type="term" value="P:xylulose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051737">
        <property type="entry name" value="L-xylulose/Carbonyl_redctase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44252">
        <property type="entry name" value="D-ERYTHRULOSE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44252:SF3">
        <property type="entry name" value="D-ERYTHRULOSE REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0793452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="245" mass="25986" checksum="1450B026D7F3A659" modified="2020-02-26" version="1">MEIQFNGKTALVSGAGKGIGNGIAKRLAMCGAQVIALDVCKESLELLKGEVPSIRIIAVDLSKWSETKQALERIGNIDLLVNNAGIAMWESLADISEDHIDQLFAINFKGVVNLTQIVIENLLKRKVGGSIVNISSIAAVCGSERRGIYSATKAAVDAFMKVVAVEMGPKGIRVNSVQPTLVMTDLGRRAVPNPQSRKSLEAGILLRRFAEVSDVVDAVLFLLSDKASMITGTCLPVDGGTLAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A8F0</accession>
    <name>A0A5N4A8F0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Roundabout</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PPYR_13158</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A8F0"/>
    <dbReference type="FunCoup" id="A0A5N4A8F0">
        <property type="interactions" value="55"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A8F0"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098632">
        <property type="term" value="F:cell-cell adhesion mediator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070593">
        <property type="term" value="P:dendrite self-avoidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000189">
        <property type="entry name" value="Neogenin isoform 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000028">
        <property type="entry name" value="Neuronal cell adhesion molecule"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000032">
        <property type="entry name" value="palladin isoform X1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001167">
        <property type="entry name" value="Roundabout 2, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000008">
        <property type="entry name" value="roundabout homolog 2 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10075">
        <property type="entry name" value="BASIGIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10075:SF100">
        <property type="entry name" value="FASCICLIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="759"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="19"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="111"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="202"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="307"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="12">
        <location>
            <begin position="415"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="12">
        <location>
            <begin position="639"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="997"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1039"/>
            <end position="1062"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAB0793538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1062" mass="115339" checksum="3E0BCDB2D2E4803D" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AAU8</accession>
    <name>A0A5N4AAU8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_11282</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0794443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AAU8"/>
    <dbReference type="InParanoid" id="A0A5N4AAU8"/>
    <dbReference type="OrthoDB" id="439808at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12363">
        <property type="entry name" value="RRM_TRA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:001225">
        <property type="entry name" value="Transformer-2 sex-determining protein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050441">
        <property type="entry name" value="RBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48034">
        <property type="entry name" value="TRANSFORMER-2 SEX-DETERMINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="128"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="228"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="33"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="83"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="228"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0794443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="274" mass="32617" checksum="4596CCB8F83CD0F2" modified="2020-02-26" version="1">MSDRGISHSPGSHKNMNDRDHSPHVRREDSPRNHKGKSYSRSPSRSRKVYRDDRDRDRRRDDRDRDSRRYRSRSRSRSDRRYKSSKYSHSRSRSHSHGRGYGRRSHSHSPMSSRRRHLGTRDNPKPSRCLGVFGLSVYTSEEELYHIFSKYGPVERVQVVIDAKTGRSRGFSFVYFESSEDAKVAKDQCNGIKINGKSIRVDFSITERAHTPTPGIYMGKPTYVSSERWDRRRDRDRESRYRRSPSPYYRRSSRRYERSRSRSYSPRLRTRPYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AB41</accession>
    <name>A0A5N4AB41_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_11372</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0794533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AB41"/>
    <dbReference type="FunCoup" id="A0A5N4AB41">
        <property type="interactions" value="22"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AB41"/>
    <dbReference type="OrthoDB" id="416786at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05930">
        <property type="entry name" value="A_NRPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000038">
        <property type="entry name" value="Ebony protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000088">
        <property type="entry name" value="Ebony protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44845:SF6">
        <property type="entry name" value="BETA-ALANINE-ACTIVATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44845">
        <property type="entry name" value="CARRIER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="32"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="569"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0794533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="859" mass="96018" checksum="53770CBD5F522EB0" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AB64</accession>
    <name>A0A5N4AB64_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_11158</name>
        <name evidence="4" type="ORF">PPYR_11409</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0794319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0794570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AB64"/>
    <dbReference type="InParanoid" id="A0A5N4AB64"/>
    <dbReference type="OrthoDB" id="6340939at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036371573" evidence="2">
        <location>
            <begin position="20"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0794319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0794570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="183" mass="20809" checksum="3909D4C21097AB96" modified="2020-02-26" version="1">MHLWFQAIILFAVTGFSKAQHFIHFVILGALGLMGLWILHMLAQDIDKVFNKPASRPPKLFWKRSIGDVDYFANRTVENVGASGETNISVDWNRILTNDPIGCVRSFACQLAAEDSKRSSTNKGNINQLFWSAKRKGWAGDEIRFALNYGTNSKKVEKCRAFYKYCPFSIDTMRDILKFFGAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ABC5</accession>
    <name>A0A5N4ABC5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Complex I-B14</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">NADH-ubiquinone oxidoreductase B14 subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PPYR_11397</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">1611_PpyrPB1</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Required for proper complex I assembly. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Mammalian complex I is composed of 45 different subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I LYR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0794558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ABC5"/>
    <dbReference type="FunCoup" id="A0A5N4ABC5">
        <property type="interactions" value="1185"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4ABC5"/>
    <dbReference type="OrthoDB" id="14535at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20266">
        <property type="entry name" value="Complex1_LYR_NDUFA6_LYRM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045299">
        <property type="entry name" value="Complex1_LYR_NDUFA6_LYRM6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016488">
        <property type="entry name" value="NADH_Ub_cplx-1_asu_su-6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12964:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12964">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE B14 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006643">
        <property type="entry name" value="NDUA6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="14">
        <location>
            <begin position="42"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00046116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAB0794558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="123" mass="14659" checksum="78E462B68290A630" modified="2020-02-26" version="1">MAANAARLIPRKVKPILSVDNEEARKRAINLYKAWCKQIPYIVRKYDIPKSVEECKQKLRDEFIKHENLTDVRVIDMLIVKGQMELKECVNIWKQKSHVMDYFHETWEPKPKDFLSKFIQGVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ACF6</accession>
    <name>A0A5N4ACF6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MSP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_11852</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0795013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4ACF6"/>
    <dbReference type="OrthoDB" id="2115465at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008285">
        <property type="term" value="P:negative regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033304">
        <property type="entry name" value="DLEC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46348">
        <property type="entry name" value="DELETED IN LUNG AND ESOPHAGEAL CANCER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46348:SF1">
        <property type="entry name" value="DELETED IN LUNG AND ESOPHAGEAL CANCER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0795013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1634" mass="186173" checksum="334A9A6562373714" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ADA8</accession>
    <name>A0A5N4ADA8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transportin-1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Importin beta-2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Karyopherin beta-2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PPYR_12143</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the importin beta family. Importin beta-2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0795304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ADA8"/>
    <dbReference type="InParanoid" id="A0A5N4ADA8"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031981">
        <property type="term" value="C:nuclear lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000028">
        <property type="entry name" value="Transportin-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040122">
        <property type="entry name" value="Importin_beta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="IMPORTIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="12">
        <location>
            <begin position="36"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00067327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00076938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00080641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAB0795304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="867" mass="98134" checksum="BD97BBC1D3F0323D" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AEV5</accession>
    <name>A0A5N4AEV5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Attacin C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_09914</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0795853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AEV5"/>
    <dbReference type="InParanoid" id="A0A5N4AEV5"/>
    <dbReference type="OrthoDB" id="6678594at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050972">
        <property type="entry name" value="SDr-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34403:SF14">
        <property type="entry name" value="OS05G0225800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34403">
        <property type="entry name" value="TOL-PAL SYSTEM PROTEIN TOLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024272256" description="Attacin C-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="479"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="279"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="491"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0795853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="565" mass="61007" checksum="DBB786B0F5BBABD3" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AH33</accession>
    <name>A0A5N4AH33_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sushi domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PPYR_10688</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AH33"/>
    <dbReference type="InParanoid" id="A0A5N4AH33"/>
    <dbReference type="OrthoDB" id="6127264at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051277">
        <property type="entry name" value="SEZ6_CSMD_C4BPB_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45656">
        <property type="entry name" value="PROTEIN CBR-CLEC-78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45656:SF4">
        <property type="entry name" value="PROTEIN CBR-CLEC-78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0768">Sushi</keyword>
    <feature type="domain" description="Sushi" evidence="5">
        <location>
            <begin position="64"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="5">
        <location>
            <begin position="123"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="5">
        <location>
            <begin position="186"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="5">
        <location>
            <begin position="254"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="93"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="156"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="222"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="281"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0796627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="314" mass="33974" checksum="6C6DA7C0AAC700FA" modified="2020-02-26" version="1">MYWQLFVSTTDILSFASGWAIASEERDWKYRLSIYYAKPQDSGTFTCSTPRGVTNSISLHVAAVHCGPISVSSMHLTVRVEGTRLGHTAIFQCPIGFKVNGNANLTCQASGKWSSSVPSCDPVRCPSLVTPGALDEPHVKVMEHNCSYGGRAVFSCAWGYQLVGPPGVECELDGNWSGPVPKCLPIQCSPPVIPVNGHLIQSESAGMDGGRYAVGSLVQFACRGAHVLEGEPSIICTETGYWSHPPPFCKPRCPYLGEPENGAVVPSKFAYEPGDELQVICNPGFESRLEARPKCLADGRWSMPLPQCTIYSEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AHI0</accession>
    <name>A0A5N4AHI0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UDP-N-acetylglucosamine transferase subunit ALG13</fullName>
            <ecNumber evidence="3">2.4.1.141</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_10810</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.141" evidence="3"/>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AHI0"/>
    <dbReference type="FunCoup" id="A0A5N4AHI0">
        <property type="interactions" value="716"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AHI0"/>
    <dbReference type="OrthoDB" id="20273at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004577">
        <property type="term" value="F:N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039042">
        <property type="entry name" value="Alg13-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007235">
        <property type="entry name" value="Glyco_trans_28_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12867">
        <property type="entry name" value="GLYCOSYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12867:SF6">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYLDIPHOSPHODOLICHOL N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04101">
        <property type="entry name" value="Glyco_tran_28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl transferase family 28 C-terminal" evidence="8">
        <location>
            <begin position="6"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0796749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="163" mass="18533" checksum="AA3A06D3018D37E9" modified="2020-02-26" version="1">MNGKRLFVTVGTTKFDKLLKTVTNEEILGILHKLGYNQIQLQVGNGSYVEVKHESIELSYNTYFEDFDNEIEKSDLVISHAGAGSCLQVLKKKKPLIVVINDDLMDNHQLELAQELERQGYLYYGTCSTLNKLLLQDITKLAEYPTSNKTLFAKYINKCMGFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AHV9</accession>
    <name>A0A5N4AHV9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_10952</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AHV9"/>
    <dbReference type="InParanoid" id="A0A5N4AHV9"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1800.10">
        <property type="entry name" value="His-Me finger endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004211">
        <property type="entry name" value="Endonuclease_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038563">
        <property type="entry name" value="Endonuclease_7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511">
        <property type="entry name" value="PROTEIN CBG23764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511:SF12">
        <property type="entry name" value="RHO TERMINATION FACTOR N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02945">
        <property type="entry name" value="Endonuclease_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="His-Me finger endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0796891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1128" mass="130936" checksum="F9123553F9F3F59E" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AKL8</accession>
    <name>A0A5N4AKL8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Multidrug resistance-associated protein lethal(2)03659</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PPYR_08839</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AKL8"/>
    <dbReference type="InParanoid" id="A0A5N4AKL8"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000973">
        <property type="entry name" value="Multidrug resistance-associated protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000026">
        <property type="entry name" value="Multidrug resistance-associated protein lethal(2)03659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000014">
        <property type="entry name" value="Multidrug resistance-associated protein member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000163">
        <property type="entry name" value="Multidrug resistance-associated protein member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF448">
        <property type="entry name" value="FI20146P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="84"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="131"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="201"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="315"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="657"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="720"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="798"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="824"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="906"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="96"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="406"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="672"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="996"/>
            <end position="1227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAB0797846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1229" mass="137077" checksum="1DA700B86828421F" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-09-13" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AKU1</accession>
    <name>A0A5N4AKU1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Follicle cell protein 3C-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_08953</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AKU1"/>
    <dbReference type="InParanoid" id="A0A5N4AKU1"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024290770" description="Follicle cell protein 3C-1" evidence="1">
        <location>
            <begin position="20"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0797960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="140" mass="15969" checksum="971E0A88FB02DA68" modified="2020-02-26" version="1">MNLFYFIFVLFLCFCTVRASEEVKTTTEKEPCPCTCGVFLSGQFDKGSKQPPKGNPALLQEMDNPFMNNAVGNRQCINKCLELIVKHLSKSAEIICATIDRDCQKEKAYLFIKNHSCEWTRTNLSAGREFCCKDNEPYKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AL54</accession>
    <name>A0A5N4AL54_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PPYR_09029</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="interactions" value="395"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AL54"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18593">
        <property type="entry name" value="ABC_6TM_MRP4_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000026">
        <property type="entry name" value="Multidrug resistance-associated protein lethal(2)03659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000014">
        <property type="entry name" value="Multidrug resistance-associated protein member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000163">
        <property type="entry name" value="Multidrug resistance-associated protein member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000482">
        <property type="entry name" value="Multidrug resistance-associated protein member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030240">
        <property type="entry name" value="ABCC4_TMD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF448">
        <property type="entry name" value="FI20146P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="88"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="275"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="315"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="713"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="783"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="853"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="881"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="966"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="97"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="429"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="719"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="1061"/>
            <end position="1294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0798036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1321" mass="149267" checksum="7AF7E62F85B44686" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ALD8</accession>
    <name>A0A5N4ALD8_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PPYR_09117</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4ALD8"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18579">
        <property type="entry name" value="ABC_6TM_ABCC_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000973">
        <property type="entry name" value="Multidrug resistance-associated protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000026">
        <property type="entry name" value="Multidrug resistance-associated protein lethal(2)03659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000014">
        <property type="entry name" value="Multidrug resistance-associated protein member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000163">
        <property type="entry name" value="Multidrug resistance-associated protein member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044746">
        <property type="entry name" value="ABCC_6TM_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF415">
        <property type="entry name" value="FI20190P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="204"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="317"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="359"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="689"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="776"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="850"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="876"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="961"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="105"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="414"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="697"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="1052"/>
            <end position="1280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAB0798124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1300" mass="145889" checksum="F11425C7BD975713" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ALK3</accession>
    <name>A0A5N4ALK3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aladin seven-bladed propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_09091</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ALK3"/>
    <dbReference type="FunCoup" id="A0A5N4ALK3">
        <property type="interactions" value="1712"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4ALK3"/>
    <dbReference type="OrthoDB" id="411991at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045139">
        <property type="entry name" value="Aladin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057403">
        <property type="entry name" value="Beta-prop_Aladin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14494:SF0">
        <property type="entry name" value="ALADIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14494">
        <property type="entry name" value="ALADIN/ADRACALIN/AAAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25460">
        <property type="entry name" value="Beta-prop_Aladin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aladin seven-bladed propeller" evidence="1">
        <location>
            <begin position="131"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0798098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="498" mass="55778" checksum="0A0B885073C9200B" modified="2020-02-26" version="1">MNNLSIFEVPTYGEVTLCEVDGKVHSMHYEFANIAAFTNSLETHPNIHITPNLLHRRSDEGKSVFVTVDEPFLKRLIHAYYEHGMIEMLNTAEEFGPSYLKNIVSVVFLVLNGVKILRNKLTSTTIENDLTLMSCISHTRFWMTSSIRCIAWDSYDIKIAVATCDDAIRIYSHNSNFIPILKCKQQKNITCLAWRPFSNSELAVGCENGIFVWNIDQTSMITRPSINNASILRRINHVPVVSIAWSPTGDILASAAARDPSILIWHVERNETSTLSMPGSHGNCLVKWSPRGNKLLTATVERVFRIWNCETWTSERWNVLTGRIQACCWSPCEGIVLFVSNTEPIIYALSFTHLEMIFATSENSATLATPLYDLSRGEIDGVIIGGTVQNMEWDPRNNIVAVLFQDTNYVAIFKVTIDPTIHLNPCCLVAGVPDEKPVCISFQGNFEHGACLSIGWSSGRVQHFPIVRPEATTSSSIISKEFYNSSSFHNSGTSFKSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AMG4</accession>
    <name>A0A5N4AMG4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">5'-3' exoribonuclease 1</fullName>
            <ecNumber evidence="12">3.1.13.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PPYR_09446</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">1611_PpyrPB1</strain>
            <tissue evidence="19">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11 12">Belongs to the 5'-3' exonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.-" evidence="12"/>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A5N4AMG4">
        <property type="interactions" value="1280"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AMG4"/>
    <dbReference type="OrthoDB" id="372487at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18673">
        <property type="entry name" value="PIN_XRN1-2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12390:FF:000004">
        <property type="entry name" value="5'-3' exoribonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12390:FF:000005">
        <property type="entry name" value="5'-3' exoribonuclease 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027073">
        <property type="entry name" value="5_3_exoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016494">
        <property type="entry name" value="5_3_exoribonuclease_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041385">
        <property type="entry name" value="SH3_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040992">
        <property type="entry name" value="XRN1_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047007">
        <property type="entry name" value="XRN1_D1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041106">
        <property type="entry name" value="XRN1_D2_D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041412">
        <property type="entry name" value="Xrn1_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004859">
        <property type="entry name" value="Xrn1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047008">
        <property type="entry name" value="XRN1_SH3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341:SF7">
        <property type="entry name" value="5'-3' EXORIBONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341">
        <property type="entry name" value="5'-&gt;3' EXORIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18129">
        <property type="entry name" value="SH3_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18332">
        <property type="entry name" value="XRN1_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18334">
        <property type="entry name" value="XRN1_D2_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17846">
        <property type="entry name" value="XRN_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03159">
        <property type="entry name" value="XRN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006743">
        <property type="entry name" value="Exonuclease_Xnr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 12" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="6 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 12" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="Xrn1 N-terminal" evidence="14">
        <location>
            <begin position="1"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Xrn1 helical" evidence="15">
        <location>
            <begin position="273"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="domain" description="5'-3' exoribonuclease 1 D1" evidence="17">
        <location>
            <begin position="680"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="domain" description="Exoribonuclease Xrn1 D2/D3" evidence="18">
        <location>
            <begin position="861"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="domain" description="5'-3' exoribonuclease 1 SH3-like" evidence="16">
        <location>
            <begin position="1115"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1474"/>
            <end position="1539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1485"/>
            <end position="1495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1500"/>
            <end position="1517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1528"/>
            <end position="1539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR006743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF17846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF18129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF18332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF18334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAB0798453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1644" mass="189030" checksum="5585504CDCBBB599" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AN04</accession>
    <name>A0A5N4AN04_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Trafficking protein particle complex subunit 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_06615</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0798735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AN04"/>
    <dbReference type="FunCoup" id="A0A5N4AN04">
        <property type="interactions" value="2129"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AN04"/>
    <dbReference type="OrthoDB" id="6278596at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012880">
        <property type="entry name" value="Gryzun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021773">
        <property type="entry name" value="TPC11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14374">
        <property type="entry name" value="FOIE GRAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14374:SF0">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11817">
        <property type="entry name" value="Foie-gras_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07919">
        <property type="entry name" value="Gryzun"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trafficking protein particle complex subunit 11" evidence="2">
        <location>
            <begin position="270"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="Gryzun putative trafficking through Golgi" evidence="1">
        <location>
            <begin position="1000"/>
            <end position="1062"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0798735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1112" mass="126794" checksum="E0BFC3CF38E7AE95" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4APF8</accession>
    <name>A0A5N4APF8_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_07071</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4APF8"/>
    <dbReference type="InParanoid" id="A0A5N4APF8"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024369360" evidence="1">
        <location>
            <begin position="17"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0799191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="199" mass="19906" checksum="07BC9FCE692AED07" modified="2020-02-26" version="1">MKFLVCVLAIVAVVCAEEEKKTEKRGLLGLGYGHAALAAPALSYGHGLGYGHGLGYGHSLGYGYGLGHGIGHGLGYGHGLGYGHGLGYGHGLGYGHGIGYSAPIVHAAAPVVHAAPVVHAAPVVHAAPAVVKTAVAAPVISKTIVAAAAPAIAVGHGYGYDHGFYGGLGHHGLGYGLGYHGLGYSGLGYSHLGYSKYLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4APK8</accession>
    <name>A0A5N4APK8_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_07121</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A5N4APK8">
        <property type="interactions" value="45"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4APK8"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026728">
        <property type="entry name" value="BLTP3A/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22774">
        <property type="entry name" value="CHOREIN N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22774:SF11">
        <property type="entry name" value="CHOREIN N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24917">
        <property type="entry name" value="BLTP3A_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="406"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1223"/>
            <end position="1305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0799241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1311" mass="146738" checksum="A1CEA04B50AE5483" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4APQ2</accession>
    <name>A0A5N4APQ2_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glycosyltransferase-like protein LARGE2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_07161</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4APQ2"/>
    <dbReference type="InParanoid" id="A0A5N4APQ2"/>
    <dbReference type="OrthoDB" id="411524at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015020">
        <property type="term" value="F:glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042285">
        <property type="term" value="F:xylosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035269">
        <property type="term" value="P:protein O-linked glycosylation via mannose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051292">
        <property type="entry name" value="Xyl/GlcA_transferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12270:SF25">
        <property type="entry name" value="GLYCOSYLTRANSFERASE-LIKE PROTEIN LARGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12270">
        <property type="entry name" value="GLYCOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13896">
        <property type="entry name" value="Glyco_transf_49"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0799281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="535" mass="61687" checksum="3D87B21D4DAC36E5" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4APW9</accession>
    <name>A0A5N4APW9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nose resistant-to-fluoxetine protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_07231</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4APW9"/>
    <dbReference type="InParanoid" id="A0A5N4APW9"/>
    <dbReference type="OrthoDB" id="118951at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006621">
        <property type="entry name" value="Nose-resist-to-fluoxetine_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052728">
        <property type="entry name" value="O2_lipid_transport_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161">
        <property type="entry name" value="O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161:SF0">
        <property type="entry name" value="O-ACYLTRANSFERASE LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20146">
        <property type="entry name" value="NRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00703">
        <property type="entry name" value="NRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024434304" description="Nose resistant-to-fluoxetine protein N-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="29"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="308"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="353"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="416"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="444"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="482"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="516"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="558"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="587"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="629"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="domain" description="Nose resistant-to-fluoxetine protein N-terminal" evidence="3">
        <location>
            <begin position="53"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0799351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="675" mass="77078" checksum="31F591903D1CA654" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2024-01-24" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AQ60</accession>
    <name>A0A5N4AQ60_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">OSK domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_07375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AQ60"/>
    <dbReference type="InParanoid" id="A0A5N4AQ60"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033447">
        <property type="entry name" value="OSK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17182">
        <property type="entry name" value="OSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OSK" evidence="1">
        <location>
            <begin position="141"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0799495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="330" mass="37725" checksum="E8C11C20C0810AE0" modified="2020-02-26" version="1">MDIRVLELQLNFESKFYVTMPFDNSDKNDLECLESEKCVSVANDQEDEWVNPQHEMKKPRIEVPPSSPPCLVGLESTKKYTSIPKGRSRFCSRQLKLDRTDLNRTYPISGGSSSIALSLSPNLESTSRMYIYPTTPPPPVPMYNGFQLVGDSQLVRFHNQVLSKGEGFARSLGYCVSGQKIADLETRIRTKPYTICDKIILLIGTNDFTHKTPMAAMCDSYDSILKLLQENGANKIILLTVPPVARMKDRKMHWTMLKRFNEHIMSLKKDEIVYPFDLASVFISYDNSVIMQCYEEKYTDGKTDLVHLNRIGFKFLQFILDINMESNSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AQL4</accession>
    <name>A0A5N4AQL4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Gamma-tubulin complex component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PPYR_07466</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation. The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation. Plays a role in neuronal migration.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the gamma-tubulin ring complex (gTuRC) consisting of TUBGCP2, TUBGCP3, TUBGCP4, TUBGCP5 and TUBGCP6 and gamma-tubulin TUBG1 or TUBG2. TUBGCP2, TUBGCP3, TUBGCP4, TUBGCP5 and TUBGCP6 assemble in a 5:5:2:1:1 stoichiometry; each is associated with a gamma-tubulin, thereby arranging 14 gamma-tubulins in a helical manner. Gamma-tubulin at the first position is blocked by TUBGCP3 at the last position, allowing 13 protafilaments to grow into a microtubule. The gTuRC (via TUBGCP3 and TUBGCP6) interacts with ACTB and MZT1; the interactions form a luminal bridge that stabilizes the initial structure during complex assembly. The gTuRC (via TUBGCP2) interacts with MZT2A/MZT2B and CDK5RAP2 (via CM1 motif); the interactions play a role in gTuRC activation. Interacts with ATF5; the ATF5:PCNT:polyglutamylated tubulin (PGT) tripartite unites the mother centriole and the pericentriolar material (PCM) in the centrosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TUBGCP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AQL4"/>
    <dbReference type="FunCoup" id="A0A5N4AQL4">
        <property type="interactions" value="1628"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AQL4"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1900:FF:000002">
        <property type="entry name" value="Gamma-tubulin complex component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF13">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4 8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="10">
        <location>
            <begin position="199"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="9">
        <location>
            <begin position="491"/>
            <end position="813"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00093403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00093572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0799586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="831" mass="96226" checksum="6088A2D63B9E6DA8" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AQW8</accession>
    <name>A0A5N4AQW8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA pseudouridine(55) synthase</fullName>
            <ecNumber evidence="2">5.4.99.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">tRNA pseudouridine 55 synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">tRNA pseudouridylate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">tRNA-uridine isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PPYR_07543</name>
        <name evidence="10" type="ORF">PPYR_12383</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pseudouridine synthase Pus10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.25" evidence="2"/>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0795544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AQW8"/>
    <dbReference type="FunCoup" id="A0A5N4AQW8">
        <property type="interactions" value="1878"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AQW8"/>
    <dbReference type="OrthoDB" id="271937at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160148">
        <property type="term" value="F:tRNA pseudouridine(55) synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2510:FF:000001">
        <property type="entry name" value="tRNA pseudouridine synthase Pus10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3190:FF:000001">
        <property type="entry name" value="tRNA pseudouridine synthase Pus10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2510">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039894">
        <property type="entry name" value="Pus10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048741">
        <property type="entry name" value="Pus10-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048742">
        <property type="entry name" value="Pus10_N_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01213">
        <property type="entry name" value="pseudo_Pus10arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21568">
        <property type="entry name" value="TRNA PSEUDOURIDINE SYNTHASE PUS10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21568:SF0">
        <property type="entry name" value="TRNA PSEUDOURIDINE SYNTHASE PUS10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21238">
        <property type="entry name" value="Pus10_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21237">
        <property type="entry name" value="Pus10_N_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pus10 N-terminal eukaryotes" evidence="8">
        <location>
            <begin position="60"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Pus10-like C-terminal" evidence="9">
        <location>
            <begin position="234"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00075270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00079393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00083669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF21237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0795544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0799663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="489" mass="56265" checksum="2B8EBC12538106B0" modified="2020-02-26" version="1">MEGKIYHYLLDQGCCKYCGLRYLQDRNIDFKNVNQYIEKKNLSTIDTEEPVVKQPKSNPCCLCLGLLQNCVIDDTVDRIVVSEVQKYDTKVFTCSISIPPAAIVREHAMRLDLRQKFAEFYLDDIEEIPLNKAWKLIIKDKISEKLGIAFENSDICNFSINVVMDYADNDQEIRIVKQLSEKIKNGDLSSRKAILSILSNCMSEKFHDIVKDPLVIPSVYLTCRRIDCKHNSIYIAGRYCKFSRELSQSPWIVDGIKAMDTSVEELIFEQINKVFSIPLTNLKFSSSGREDCDVRCLGKGRPFYIEILDPKKTLFTDDEFRKLESDINKSRLIEVRDLQSVQRSELGKIKEGEQLKTKEYIALCLTKDTITQEQIDKINNYGKITLEQKTPVRVLHRRPLAVRKKNVLRMEARLVPDKTKLFELLLETEAGTYVKEFVHGDFGRTKPSIGDIIGDAVDIIALDVIAIHLDWPKEIKASNEMYIEHASNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AQY8</accession>
    <name>A0A5N4AQY8_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_07508</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AQY8"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050909">
        <property type="term" value="P:sensory perception of taste"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013604">
        <property type="entry name" value="7TM_chemorcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000203">
        <property type="entry name" value="GPS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08395">
        <property type="entry name" value="7tm_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01825">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0799628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1462" mass="165374" checksum="E5D50BBB6B30B8ED" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AR04</accession>
    <name>A0A5N4AR04_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PPYR_07637</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AR04"/>
    <dbReference type="FunCoup" id="A0A5N4AR04">
        <property type="interactions" value="107"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AR04"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060076">
        <property type="term" value="C:excitatory synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005313">
        <property type="term" value="F:L-glutamate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005326">
        <property type="term" value="F:neurotransmitter transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098700">
        <property type="term" value="P:neurotransmitter loading into synaptic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050803">
        <property type="term" value="P:regulation of synapse structure or activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035249">
        <property type="term" value="P:synaptic transmission, glutamatergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000226">
        <property type="entry name" value="Vesicular GLUtamate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000264">
        <property type="entry name" value="vesicular glutamate transporter 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050382">
        <property type="entry name" value="MFS_Na/Anion_cotransporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662:SF456">
        <property type="entry name" value="VESICULAR GLUTAMATE TRANSPORTER, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="270"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="307"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="344"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="370"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="402"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="434"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="41"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="512"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="540"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0799757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="555" mass="61691" checksum="6A47B6749AF55B2C" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ARZ1</accession>
    <name>A0A5N4ARZ1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="22">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">PPYR_07974</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">1611_PpyrPB1</strain>
            <tissue evidence="27">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17 22">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38567"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:38568"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 21">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 22">Membrane</location>
            <topology evidence="2 22">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 22">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="27">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="22"/>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0800094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ARZ1"/>
    <dbReference type="FunCoup" id="A0A5N4ARZ1">
        <property type="interactions" value="815"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4ARZ1"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090556">
        <property type="term" value="F:phosphatidylserine floppase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02073">
        <property type="entry name" value="P-type_ATPase_APLT_Dnf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000021">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000035">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000010">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF150">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 20 22" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12 21 22" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 21" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 20 22" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13 22" id="KW-1278">Translocase</keyword>
    <keyword evidence="8 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 22" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="316"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="862"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="893"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="935"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="976"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="1008"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="1033"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="25">
        <location>
            <begin position="59"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="24">
        <location>
            <begin position="153"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="26">
        <location>
            <begin position="826"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="19">
        <location>
            <position position="429"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="429"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="429"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="430"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="431"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="431"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="506"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="547"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="570"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="604"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="684"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="685"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="686"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="774"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="780"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="800"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="803"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="804"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="804"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00034036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00051303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU362033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF16209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="KAB0800094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1129" mass="127634" checksum="BCAB036031ADC858" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AS56</accession>
    <name>A0A5N4AS56_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Coronin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PPYR_07928</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">F-actin regulator involved in anterograde Golgi to endosome transport: upon ubiquitination via 'Lys-33'-linked ubiquitin chains by the BCR(KLHL20) E3 ubiquitin ligase complex, interacts with EPS15 and localizes to the trans-Golgi network, where it promotes actin polymerization, thereby facilitating post-Golgi trafficking. May play a role in the maintenance of the Golgi apparatus morphology.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the WD repeat coronin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0800048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AS56"/>
    <dbReference type="FunCoup" id="A0A5N4AS56">
        <property type="interactions" value="413"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AS56"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000076">
        <property type="entry name" value="Coronin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000362">
        <property type="entry name" value="Coronin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015505">
        <property type="entry name" value="Coronin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015048">
        <property type="entry name" value="DUF1899"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10856">
        <property type="entry name" value="CORONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10856:SF20">
        <property type="entry name" value="CORONIN-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08953">
        <property type="entry name" value="DUF1899"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16300">
        <property type="entry name" value="WD40_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01166">
        <property type="entry name" value="DUF1899"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01167">
        <property type="entry name" value="DUF1900"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101908">
        <property type="entry name" value="Putative isomerase YbhE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8 9" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="DUF1899" evidence="11">
        <location>
            <begin position="4"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="75"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="167"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1899" evidence="11">
        <location>
            <begin position="644"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="768"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="811"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="390"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="426"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="467"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="439"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="486"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="599"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="611"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU280818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAB0800048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1114" mass="124150" checksum="4659E16C04E00A26" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ASK9</accession>
    <name>A0A5N4ASK9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Vacuolar protein sorting-associated protein 28 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PPYR_06029</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process.</text>
    </comment>
    <comment type="function">
        <text evidence="5">Component of the ESCRT-I complex, a regulator of vesicular trafficking process.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the ESCRT-I complex (endosomal sorting complex required for transport I).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the VPS28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000004">
        <property type="protein sequence ID" value="KAB0800289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ASK9"/>
    <dbReference type="FunCoup" id="A0A5N4ASK9">
        <property type="interactions" value="1708"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4ASK9"/>
    <dbReference type="OrthoDB" id="2671at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1130:FF:000001">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 28 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1440.200:FF:000001">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 28 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037202">
        <property type="entry name" value="ESCRT_assembly_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007143">
        <property type="entry name" value="Vps28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017899">
        <property type="entry name" value="VPS28_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037206">
        <property type="entry name" value="VPS28_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017898">
        <property type="entry name" value="VPS28_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038358">
        <property type="entry name" value="VPS28_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12937">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING 28, ISOFORM 2 VPS28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12937:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 28 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03997">
        <property type="entry name" value="VPS28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017535">
        <property type="entry name" value="VPS28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140111">
        <property type="entry name" value="Endosomal sorting complex assembly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140427">
        <property type="entry name" value="VPS28 C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51310">
        <property type="entry name" value="VPS28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51313">
        <property type="entry name" value="VPS28_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0967">Endosome</keyword>
    <keyword evidence="4 7 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7 8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VPS28 N-terminal" evidence="10">
        <location>
            <begin position="4"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="VPS28 C-terminal" evidence="9">
        <location>
            <begin position="115"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00056039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00066174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR017535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0800289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="213" mass="24551" checksum="AF4B8396AAC28767" modified="2020-02-26" version="1">MAVNQDNRPELYEEVKLYQNAREREKFDNLADLYAVINTLQQLEKAYIRDCVVPKEYTGACSKLLVQYKAAFRQVESDSFPTVDAFVRKYRLDCPAALERIKEGHPITIRDDKGNTSKCIADIVSLFITLMDKLRLGITAMDELHPELKDLVDTMQRFSIIPSAFEGKQKMIEWLNTLDSMKVSDELSETQVRQLLFDLESSYAAFNKLLHNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ASV3</accession>
    <name>A0A5N4ASV3_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_06164</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000004">
        <property type="protein sequence ID" value="KAB0800424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ASV3"/>
    <dbReference type="InParanoid" id="A0A5N4ASV3"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="24"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0800424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="175" mass="20721" checksum="96EE7FD9619171F5" modified="2020-02-26" version="1">MEKLQSINNLYAEQSIVTDLIYELKMVTNEKLNLDRENVALKLENQDLRQKLEAAECNTKIRKNLFDFQGLDNEELRERKLSMLEISNLKLSYCKQRELFEQRQDVLLLQIKHLETKLNENNEVLNDLRVKSEKNYKKYVSYKNKIKQAVIVIKNLASGKAEKRSNKTCQTEHNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ATX4</accession>
    <name>A0A5N4ATX4_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_06508</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000004">
        <property type="protein sequence ID" value="KAB0800769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ATX4"/>
    <dbReference type="InParanoid" id="A0A5N4ATX4"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027871">
        <property type="entry name" value="DUF4603"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17611">
        <property type="entry name" value="DNA SEGMENT, CHR 5, ERATO DOI 579, EXPRESSED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17611:SF3">
        <property type="entry name" value="DNA SEGMENT, CHR 5, ERATO DOI 579, EXPRESSED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15376">
        <property type="entry name" value="DUF4603"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0800769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="805" mass="91969" checksum="1D7C37C610D43548" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AW49</accession>
    <name>A0A5N4AW49_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cation/H+ exchanger transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PPYR_05901</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000003">
        <property type="protein sequence ID" value="KAB0801547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AW49"/>
    <dbReference type="FunCoup" id="A0A5N4AW49">
        <property type="interactions" value="552"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AW49"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015386">
        <property type="term" value="F:potassium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051453">
        <property type="term" value="P:regulation of intracellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098719">
        <property type="term" value="P:sodium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018422">
        <property type="entry name" value="Cation/H_exchanger_CPA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002090">
        <property type="entry name" value="NHE-6/7/9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110">
        <property type="entry name" value="SODIUM/HYDROGEN EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110:SF187">
        <property type="entry name" value="SODIUM_HYDROGEN EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01088">
        <property type="entry name" value="NAHEXCHNGR6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="10" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="96"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="13">
        <location>
            <begin position="2"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="199"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="201"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAB0801547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="324" mass="36420" checksum="CFEF6A38C5AFCDB0" modified="2020-02-26" version="1">MTKFTRVRDFPLLESALFVLMSYSTFLIAEAANLTGIVAVLFCGICQAHYTYNNLSDDSRMRTKQMFELLNFLAENFIFSYIGVSMFTFPKHHFDPLFILAGFTCAAIGRATNIYPLSFLLNLGRKPKIPGNFQHMLFFAGLRGAMSFALAIRNTVSEARQAMLTTTSLIVIITVIIQGGAAMNLLRWFQIPIGMEEETEPLSNQGSRSGNTTPRCEWADSTGQEMPKPNEKAFLARAWGSFDTHYMKPLLTHSRPTLLETLPVCCNPIARLLTTTEQMTQDGQNRITRDSDSDLCIEESDYLHNDARHSNMHRPVHAISGNQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AXB1</accession>
    <name>A0A5N4AXB1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Beta-galactosidase</fullName>
            <ecNumber evidence="5">3.2.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PPYR_04109</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="5"/>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0801923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AXB1"/>
    <dbReference type="FunCoup" id="A0A5N4AXB1">
        <property type="interactions" value="651"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AXB1"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000049">
        <property type="entry name" value="Beta-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026283">
        <property type="entry name" value="B-gal_1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048912">
        <property type="entry name" value="BetaGal1-like_ABD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048913">
        <property type="entry name" value="BetaGal_gal-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031330">
        <property type="entry name" value="Gly_Hdrlase_35_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019801">
        <property type="entry name" value="Glyco_hydro_35_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001944">
        <property type="entry name" value="Glycoside_Hdrlase_35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23421">
        <property type="entry name" value="BETA-GALACTOSIDASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21317">
        <property type="entry name" value="BetaGal_ABD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21467">
        <property type="entry name" value="BetaGal_gal-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01301">
        <property type="entry name" value="Glyco_hydro_35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006336">
        <property type="entry name" value="B-gal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00742">
        <property type="entry name" value="GLHYDRLASE35"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01182">
        <property type="entry name" value="GLYCOSYL_HYDROL_F35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase 35 catalytic" evidence="7">
        <location>
            <begin position="27"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-galactosidase 1-like first all-beta" evidence="8">
        <location>
            <begin position="438"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-galactosidase galactose-binding" evidence="9">
        <location>
            <begin position="580"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR006336-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF21317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0801923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="672" mass="76827" checksum="05C3299D8ACB4BC8" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AXK1</accession>
    <name>A0A5N4AXK1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">poly(A)-specific ribonuclease</fullName>
            <ecNumber evidence="6">3.1.13.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Carbon catabolite repressor protein 4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Cytoplasmic deadenylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Glucose-repressible alcohol dehydrogenase transcriptional effector</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">PPYR_04164</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">1611_PpyrPB1</strain>
            <tissue evidence="24">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>Exonucleolytic cleavage of poly(A) to 5'-AMP.</text>
            <dbReference type="EC" id="3.1.13.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the CCR4/nocturin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.4" evidence="6"/>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0801978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AXK1"/>
    <dbReference type="FunCoup" id="A0A5N4AXK1">
        <property type="interactions" value="2134"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AXK1"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004535">
        <property type="term" value="F:poly(A)-specific ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09097">
        <property type="entry name" value="Deadenylase_CCR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000002">
        <property type="entry name" value="CCR4-NOT transcription complex subunit 6 like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050410">
        <property type="entry name" value="CCR4/nocturin_mRNA_transcr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121">
        <property type="entry name" value="CARBON CATABOLITE REPRESSOR PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121:SF100">
        <property type="entry name" value="POLY(A)-SPECIFIC RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="17" id="KW-0804">Transcription</keyword>
    <keyword evidence="16" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="23">
        <location>
            <begin position="194"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00030493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00031469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00033317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KAB0801978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="561" mass="63973" checksum="0ABA3E6FF48D74FB" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AXL0</accession>
    <name>A0A5N4AXL0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PPYR_04086</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0801900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AXL0"/>
    <dbReference type="FunCoup" id="A0A5N4AXL0">
        <property type="interactions" value="1386"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AXL0"/>
    <dbReference type="OrthoDB" id="431068at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12503">
        <property type="entry name" value="RRM1_hnRNPH_GRSF1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12504">
        <property type="entry name" value="RRM2_hnRNPH_CRSF1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000031">
        <property type="entry name" value="Heterogeneous nuclear ribonucleoprotein h3 isoform"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000131">
        <property type="entry name" value="Heterogeneous nuclear ribonucleoprotein h3 isoform"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050666">
        <property type="entry name" value="ESRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13976">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="11"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="110"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="300"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAB0801900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="407" mass="44378" checksum="A91CD77D1A3C60A9" modified="2020-02-26" version="1">MSGAGDQDDDCVVKLRGLPWSATQDDIVKFFKECAIMGGKSGVHMTTSREGRPSGEAFVELESTEDVRRAIQRDHDHMGNRYIEVFKVNRAEMDWVIKRCAPMNGSDEDGCVRLRGLPFGCSKEEIAQFFTGLEIVPNGITLLTDGSGRSSGEAYVQFVSKEVAEKALLKHREKIGHRYIEIFRSSLSEVQSVVGINNRRMGGGGGGPGMGYNSRPGPYDRGDRYGNMNRFQSRGSRSFKGSLFSNNVSDRKYSDYDDFGELPSPWLNNSNHNGDMGSDNSPYGGHSWESPEECGGGGVHCVHMRGLPFKANQMDIADFFRPIIPVSIRLLQDNSGRASGEADVEFASHEDAVRAMNKDKGHMQHRYIELFLNSSSSGGGGGGMGGGGGGNGGGYLSYGGYGGRRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AXQ7</accession>
    <name>A0A5N4AXQ7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PPYR_04310</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AXQ7"/>
    <dbReference type="InParanoid" id="A0A5N4AXQ7"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024435249" description="Major facilitator superfamily (MFS) profile domain-containing protein" evidence="6">
        <location>
            <begin position="31"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="167"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="224"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="339"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="368"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="401"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="456"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="67"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0802124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="503" mass="56131" checksum="47612DFFF788CB73" modified="2020-02-26" version="1">MSTLMALLRFPTAWIQLGIVFLAPPTEFWCKPPREYKFMDVDKWKQLTNIPNDTFKSHSTLEYGNCKMWYPANGSVIPCIWGYAYNRSVIHSSIITEWNLVCNKSHLIEFSQIVLMFGVLIGSIWLGLAADKLGRARVLMFAIVSQSIFGLLTGILPWFSTFLVSRFFLAVANGGVSVISFVLCMEVVGGAWRTIVPILYHIPFGLGTSMMAFAAYFLRDWRCLQLTLFGLSALYLSYIWMISESPRWLWVVGKKQESIAILEKAACVNQLDLMQLKLAIDSIHGSPPVKYTNEELGLRMLFKTPELRSRTIKLCLSSVISGMNFLGFSEYLGQISANIYLGVAIGGIAVIPGSFTCIYVINRYGRTMSISCAACFIGMCFFGICFFPLDVYKNDWPRILLSGSGFFGMSIAYPALCLFTGELFPTILRNAGLGTTVMFSKLGSMIAPIVLQSGEYATFVPLLILGSTSFIQAALVLPLPDTLNKRLPDTIEDVEEMHGYQKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AYU2</accession>
    <name>A0A5N4AYU2_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">HECT domain and RCC1-like domain-containing protein 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">HECT-type E3 ubiquitin transferase HERC2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">PPYR_04701</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">1611_PpyrPB1</strain>
            <tissue evidence="25">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Centrosome</location>
            <location evidence="2">Centriole</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="4"/>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A5N4AYU2">
        <property type="interactions" value="1611"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AYU2"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd08664">
        <property type="entry name" value="APC10-HERC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000015">
        <property type="entry name" value="E3 ubiquitin-protein ligase HERC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.30:FF:000003">
        <property type="entry name" value="E3 ubiquitin-protein ligase HERC2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.30:FF:000006">
        <property type="entry name" value="E3 ubiquitin-protein ligase HERC2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000074">
        <property type="entry name" value="E3 ubiquitin-protein ligase HERC2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.30:FF:000004">
        <property type="entry name" value="E3 ubiquitin-protein ligase HERC2 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000010">
        <property type="entry name" value="E3 ubiquitin-protein ligase HERC2 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000006">
        <property type="entry name" value="probable E3 ubiquitin-protein ligase HERC1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004939">
        <property type="entry name" value="APC_su10/DOC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021097">
        <property type="entry name" value="CPH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037976">
        <property type="entry name" value="HERC2_APC10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010606">
        <property type="entry name" value="Mib_Herc2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037252">
        <property type="entry name" value="Mib_Herc2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058923">
        <property type="entry name" value="RCC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051625">
        <property type="entry name" value="Signaling_Regulatory_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22872">
        <property type="entry name" value="BTK-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22872:SF2">
        <property type="entry name" value="INHIBITOR OF BRUTON TYROSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03256">
        <property type="entry name" value="ANAPC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11515">
        <property type="entry name" value="Cul7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06701">
        <property type="entry name" value="MIB_HERC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25390">
        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00569">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SMART" id="SM01337">
        <property type="entry name" value="APC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159034">
        <property type="entry name" value="Mib/herc2 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51284">
        <property type="entry name" value="DOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51416">
        <property type="entry name" value="MIB_HERC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01357">
        <property type="entry name" value="ZF_ZZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50135">
        <property type="entry name" value="ZF_ZZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="11 16" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 17" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="RCC1" evidence="18">
        <location>
            <begin position="530"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="18">
        <location>
            <begin position="582"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="18">
        <location>
            <begin position="636"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="18">
        <location>
            <begin position="688"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="18">
        <location>
            <begin position="740"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="22">
        <location>
            <begin position="1174"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="domain" description="MIB/HERC2" evidence="24">
        <location>
            <begin position="1895"/>
            <end position="1968"/>
        </location>
    </feature>
    <feature type="domain" description="ZZ-type" evidence="20">
        <location>
            <begin position="2714"/>
            <end position="2765"/>
        </location>
    </feature>
    <feature type="domain" description="DOC" evidence="23">
        <location>
            <begin position="2768"/>
            <end position="2943"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="18">
        <location>
            <begin position="2969"/>
            <end position="3020"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="18">
        <location>
            <begin position="3021"/>
            <end position="3074"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="18">
        <location>
            <begin position="3075"/>
            <end position="3126"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="18">
        <location>
            <begin position="3127"/>
            <end position="3178"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="18">
        <location>
            <begin position="3181"/>
            <end position="3232"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="18">
        <location>
            <begin position="3233"/>
            <end position="3284"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="18">
        <location>
            <begin position="3285"/>
            <end position="3336"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="18">
        <location>
            <begin position="3954"/>
            <end position="4005"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="18">
        <location>
            <begin position="4006"/>
            <end position="4059"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="18">
        <location>
            <begin position="4060"/>
            <end position="4111"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="18">
        <location>
            <begin position="4112"/>
            <end position="4163"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="18">
        <location>
            <begin position="4166"/>
            <end position="4217"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="18">
        <location>
            <begin position="4218"/>
            <end position="4269"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="18">
        <location>
            <begin position="4270"/>
            <end position="4321"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="21">
        <location>
            <begin position="4460"/>
            <end position="4787"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1320"/>
            <end position="1347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1561"/>
            <end position="1599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="2522"/>
            <end position="2543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="3432"/>
            <end position="3452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="4802"/>
            <end position="4821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="1331"/>
            <end position="1347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="1587"/>
            <end position="1598"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="16">
        <location>
            <position position="4755"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00080834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00081609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="KAB0802515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="4821" mass="533975" checksum="E5C66A6E26134F3A" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-06-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B0B9</accession>
    <name>A0A5N4B0B9_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_05179</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B0B9"/>
    <dbReference type="InParanoid" id="A0A5N4B0B9"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0802993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="65" mass="7353" checksum="2FE0117520DDC57D" modified="2020-02-26" version="1">MDATEAKQKNHGGVLTSVMAVQQRTADAVQVSKQTVVRTCAMREIGSDLKRNTYRRSKPRRTDLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B0C9</accession>
    <name>A0A5N4B0C9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TOG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_05189</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0803003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A5N4B0C9">
        <property type="interactions" value="27"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4B0C9"/>
    <dbReference type="OrthoDB" id="63891at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005881">
        <property type="term" value="C:cytoplasmic microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21567">
        <property type="entry name" value="CLASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21567:SF87">
        <property type="entry name" value="CRESCERIN-LIKE PROTEIN CHE-12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TOG" evidence="2">
        <location>
            <begin position="642"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="domain" description="TOG" evidence="2">
        <location>
            <begin position="1397"/>
            <end position="1626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="402"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="507"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="943"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1006"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1121"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1364"/>
            <end position="1401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="423"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="516"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="955"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1160"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1181"/>
            <end position="1197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0803003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1628" mass="182283" checksum="D337D197A5336E80" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B0I9</accession>
    <name>A0A5N4B0I9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_00075</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B0I9"/>
    <dbReference type="InParanoid" id="A0A5N4B0I9"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF85">
        <property type="entry name" value="GH03217P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0803105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="122" mass="13915" checksum="74004DF662EBF95C" modified="2020-02-26" version="1">MPTVDVEKKVLLTIWLLAKLETFLACGDRFGVSRSSAHYIFKQIVVILSSLVDEYIIWPNQRQCEETARIFEERSGIPNVIGAIDGTHIFIKQPVGNSIDYYNRYQCHSVVLQVVCNANKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B0M6</accession>
    <name>A0A5N4B0M6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">FLYWCH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PPYR_00073</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B0M6"/>
    <dbReference type="InParanoid" id="A0A5N4B0M6"/>
    <dbReference type="OrthoDB" id="6783931at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018289">
        <property type="entry name" value="MULE_transposase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007588">
        <property type="entry name" value="Znf_FLYWCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47160:SF10">
        <property type="entry name" value="MULE TRANSPOSASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47160">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04500">
        <property type="entry name" value="FLYWCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10551">
        <property type="entry name" value="MULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FLYWCH-type" evidence="4">
        <location>
            <begin position="5"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="MULE transposase" evidence="5">
        <location>
            <begin position="186"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0803103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="467" mass="53928" checksum="F1C2F203BDE038D1" modified="2020-02-26" version="1">MALQFIESEKRKPKLCVNNHIYYKDKVVDETTYWKCEKFQITKCKARMSTQGERIVSHGKKEHNHVADVAKVECDKILNNIKDTARNTRDSPHVIVSDASVGVSLAIAGRLPSVDCMKKTIRNIRAKENPGPVLPLHRRDIVFPELYTLTENQEIFLMFDSGPQDDRILIFSTRRNLQLLARSSHWYADGTFKVSPPLFAQLYTIHGLRHSNSIPLVYALLPDKTHNTYVRLLGQIKQLEATVNPETILIDYESAIIGAIESEFPGVVVRGCFFHFCQCIFRSIQSNGLQQRYETDADFALTMRYLSALAFVPLNELVQSFDLLLDNNVFPPEAQPVIDYFEDTWIGRPDRRLRRRAPRFAHVMWNCYNSVLENLPKTNNALEGWHRGFQEMLGGNHPNIWKFVNALKKEQSLNELRIEQYHSGQQPPASRKKYRDCAERIRRLILDFDPANDVVPYLRGIAHNITY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B114</accession>
    <name>A0A5N4B114_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_00257</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B114"/>
    <dbReference type="InParanoid" id="A0A5N4B114"/>
    <dbReference type="OrthoDB" id="6740702at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0803287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="462" mass="51337" checksum="80CEB527B2DC320B" modified="2020-02-26" version="1">MAAHFKSMCAAFDAGFLSEDAMVKVCEQLHNMITSGEVIPEEEDIVHFRRLRDVVGTIQTRLLQQNVNAQQVNTGVVPQSQPVDLTVTNTLQHPTMTAKTQSQPLDLTVNPHVSKTASENVLTQSQPMDLTVKNAPRPATSGVKPNRKRAAPCVNNFLNPQHSTSGLQQATPTGSNNINSEPSTSGLHQLSPQVGRGVPRRFLVLSEGERVIKKFNLTAQQLTIKFDDAEPNEAPLEWLKKSLTALINYITKRRSVSDRIGLMLTNSEFPDNPLGFSFRRIDQLNANVMLKTMDKVMQSNKAFFSSDALRVDVSLITLPNGKGRQRMTGVTFEEFSQRKHGIILINNNDTLCLARALVTAIAFRNNSPDLPYLKVGHALQTEKARELYAAAGVDLSNGGTIEHIRQFQNYLTDFTIVVYNHRLGKTVYFEGPRAPQRQVLNLLMENEHYNVITSLTSAFSCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B123</accession>
    <name>A0A5N4B123_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DDE-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_00188</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B123"/>
    <dbReference type="InParanoid" id="A0A5N4B123"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15517">
        <property type="entry name" value="PHD_TCF19_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF74">
        <property type="entry name" value="POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
        <property type="entry name" value="HTH_psq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH psq-type" evidence="4">
        <location>
            <begin position="15"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="DDE-1" evidence="3">
        <location>
            <begin position="216"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="512"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0803218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="605" mass="68605" checksum="AF60E6AA7F55F26F" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B371</accession>
    <name>A0A5N4B371_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_00800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM154 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B371"/>
    <dbReference type="InParanoid" id="A0A5N4B371"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005879">
        <property type="term" value="C:axonemal microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036126">
        <property type="term" value="C:sperm flagellum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033336">
        <property type="entry name" value="SAXO1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31516">
        <property type="entry name" value="STABILIZER OF AXONEMAL MICROTUBULES 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31516:SF16">
        <property type="entry name" value="TITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="198"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="236"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="333"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="431"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="458"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="565"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="236"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="335"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="438"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="458"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="565"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0803830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="703" mass="80418" checksum="9B7A84ECE60F0C89" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B3C6</accession>
    <name>A0A5N4B3C6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_01034</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B3C6"/>
    <dbReference type="InParanoid" id="A0A5N4B3C6"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11416">
        <property type="entry name" value="bHLH_TS_ceHLH13_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000035">
        <property type="entry name" value="Pancreas-specific transcription factor 1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050283">
        <property type="entry name" value="E-box_TF_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23349">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, TWIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23349:SF97">
        <property type="entry name" value="BHLH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="6">
        <location>
            <begin position="88"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0804064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="208" mass="23012" checksum="3078424A1E9CAB89" modified="2020-02-26" version="1">MSSGRSQMPDSSSSPPISLQYGGYGGGDLSEDEVSDLPSCAFATRAASSNSIQHHYLTSLHHGNDNAQCAASSLSASEYYGGSPYRIQRHAANIRERKRMLSSINSAFDELRMHVPTFPYEKRLSKIDTLRLAIAYIALLREVLTADCDPLTYVERCLRGDIKADRAHWNTSDLTARLSWINWENLGVNPGRRSNVSSLSISSENMSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B6J4</accession>
    <name>A0A5N4B6J4_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_02156</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0805186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B6J4"/>
    <dbReference type="InParanoid" id="A0A5N4B6J4"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004211">
        <property type="entry name" value="Endonuclease_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511">
        <property type="entry name" value="PROTEIN CBG23764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31511:SF12">
        <property type="entry name" value="RHO TERMINATION FACTOR N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02945">
        <property type="entry name" value="Endonuclease_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="His-Me finger endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="742"/>
            <end position="764"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0805186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="784" mass="91027" checksum="BB43C6853062CBCB" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B788</accession>
    <name>A0A5N4B788_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Protein krueppel</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PPYR_02429</name>
        <name evidence="14" type="ORF">PPYR_02439</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0805459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0805469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4B788"/>
    <dbReference type="FunCoup" id="A0A5N4B788">
        <property type="interactions" value="177"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4B788"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000256">
        <property type="entry name" value="PLAG1 like zinc finger 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000478">
        <property type="entry name" value="Zinc finger protein 133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000512">
        <property type="entry name" value="zinc finger protein 197 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000736">
        <property type="entry name" value="Zinc finger protein 423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001289">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012934">
        <property type="entry name" value="Znf_AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF29">
        <property type="entry name" value="MYONEURIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07776">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00868">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51915">
        <property type="entry name" value="ZAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZAD" evidence="12">
        <location>
            <begin position="20"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="185"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="213"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="241"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="269"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="297"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="325"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAB0805459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAB0805469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="348" mass="40055" checksum="09C17E12306CE23A" modified="2020-02-26" version="1">MNDDSNKNFVNLFCDFSFNTVCRLCLEKTQPNKKMSQLFEPKQNNLISDLPGMIMACASIQIIEGDGLPSTICSKCLAKLNVAWQFKLQCENSDAKLRQFYFNNSSQLPIAPVFDGFGFDLKHEQHVCVLKSELDVANSYNNTSELISGGNLATPPPLKREQECKKVKTKKIKRQKTERKDLKIHQCDTCGKTFNRREYLTQHIRIHTGEKPYHCHLCEKRFVNSGHLTTHMRTHTGERPHSCTLCPKAFSTRQELHKHTMVHNGDRPFVCKMCGKCFGSSSNLYSHLKHHTGEKNFTCEHCGKAFYTKQELKQHLVVHTGEKAFLCELCNKRFSQIAHLRRHSKLHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4B7W9</accession>
    <name>A0A5N4B7W9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Regulator of G-protein signaling loco</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_02675</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0805705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A5N4B7W9">
        <property type="interactions" value="806"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4B7W9"/>
    <dbReference type="OrthoDB" id="196547at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048699">
        <property type="term" value="P:generation of neurons"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008277">
        <property type="term" value="P:regulation of G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06710">
        <property type="entry name" value="PDZ_RGS12-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01817">
        <property type="entry name" value="RBD1_RGS12_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17067">
        <property type="entry name" value="RBD2_RGS12_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.167.10:FF:000001">
        <property type="entry name" value="Putative regulator of g-protein signaling 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.196.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003109">
        <property type="entry name" value="GoLoco_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006020">
        <property type="entry name" value="PTB/PI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003116">
        <property type="entry name" value="RBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046995">
        <property type="entry name" value="RGS10/12/14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024066">
        <property type="entry name" value="RGS_subdom1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45945">
        <property type="entry name" value="REGULATOR OF G-PROTEIN SIGNALING LOCO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45945:SF3">
        <property type="entry name" value="REGULATOR OF G-PROTEIN SIGNALING LOCO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02196">
        <property type="entry name" value="RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01301">
        <property type="entry name" value="RGSPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00390">
        <property type="entry name" value="GoLoco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00462">
        <property type="entry name" value="PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00455">
        <property type="entry name" value="RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50877">
        <property type="entry name" value="GOLOCO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50898">
        <property type="entry name" value="RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
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                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
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                <person name="Wong I."/>
                <person name="Day J.C."/>
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                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
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                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="JAV59659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAB0794247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="526" mass="60026" checksum="94CCBC7AF6577DBE" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1KI30</accession>
    <name>A0A1Y1KI30_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zinc transporter ZIP11</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Solute carrier family 39 member 11</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Zrt- and Irt-like protein 11</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PPYR_10787</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ZIP transporter (TC 2.A.5) family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01085921">
        <property type="protein sequence ID" value="JAV59890.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1KI30"/>
    <dbReference type="FunCoup" id="A0A1Y1KI30">
        <property type="interactions" value="177"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1KI30"/>
    <dbReference type="OrthoDB" id="262547at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF211">
        <property type="entry name" value="ZINC TRANSPORTER ZIP11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="80"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00042540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00042973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="JAV59890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAB0796726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="338" mass="35942" checksum="2AFD10C2DCB99360" modified="2017-08-30" version="1">MLPEYGPVMQALLGTLFTWVLTALGAALVIFIRGSHRKCLDISLGFAAGVMTAASFWSLLAPAIEMAEQSQTYGDKGQFAFVPVGCGFLLGALFVYGADVLITLLGVHSPNMMLALHSKATRKEKQENNSGKSPVYAIETTAIDGFHEHGNNLQFRGRVRGRTSDEIVHSHTFEDVSNIEEIQHGQWRRMMLLVIAITAHNVPEGLAVGVGFGAIGSTASATFESARNLAIGIGIQNFPEGLAVSLPLHAAGFSLWKSLWYGQLSGMVEPIFGVMGAVAVSVARPVLPYALSFAAGAMIYVVIDDIIPEANTSGNGKLATWGAICGFLIMMTLDVGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1KLL5</accession>
    <name>A0A1Y1KLL5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">protein-serine/threonine phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_09639</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="1"/>
    <dbReference type="EMBL" id="GEZM01080349">
        <property type="protein sequence ID" value="JAV62204.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1KLL5"/>
    <dbReference type="FunCoup" id="A0A1Y1KLL5">
        <property type="interactions" value="340"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1KLL5"/>
    <dbReference type="OrthoDB" id="277011at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008420">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000013">
        <property type="entry name" value="Carboxy-terminal domain RNA polymerase II polypeptide A small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011948">
        <property type="entry name" value="Dullard_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040078">
        <property type="entry name" value="RNA_Pol_CTD_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02251">
        <property type="entry name" value="HIF-SF_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01124">
        <property type="entry name" value="C0.1:_RNA_Pol_CTD_Phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FCP1 homology" evidence="7">
        <location>
            <begin position="96"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="76"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="4">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="5">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="5">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR640078-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR640078-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="JAV62204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0798646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="295" mass="33242" checksum="BA2C9F0578B2CA50" modified="2017-08-30" version="1">MDASSIITQVSRDDEQLNSYPPEKGSLTRTDNDISEIKVSQPGNKKVKRGFLRTLLCCLGRNRSKSQNPKQYAFGSDSPTSPTDSPRFLLPPVRHQDMHKMCMVIDLDETLVHSSFKPISNADFVVPVEIDGTVHQVYVLKRPHVDDFLKRMGELYECVLFTASLAKYADPVADLLDKWGVFRARLFRESCVFHRGNYVKDLNKLGRELQQIVIVDNSPASYIFHPDNAVPVASWFDDMSDSELLDLIPFFEKLSKMDSVYTVLCNSNHPFNNGVLKNLSGHSSAAQTPRDTPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1KLQ4</accession>
    <name>A0A1Y1KLQ4_PHOPY</name>
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            <fullName evidence="8">Complex III assembly factor LYRM7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PPYR_04001</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I LYR family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01081798">
        <property type="protein sequence ID" value="JAV61528.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0801815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1KLQ4"/>
    <dbReference type="FunCoup" id="A0A1Y1KLQ4">
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    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1KLQ4"/>
    <dbReference type="OrthoDB" id="529194at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20267">
        <property type="entry name" value="Complex1_LYR_LYRM7"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Complex1_LYR_LYRM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050435">
        <property type="entry name" value="MZM1/LYRM7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46749">
        <property type="entry name" value="COMPLEX III ASSEMBLY FACTOR LYRM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46749:SF1">
        <property type="entry name" value="COMPLEX III ASSEMBLY FACTOR LYRM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="JAV61528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0801815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="100" mass="11784" checksum="DF791F917339E879" modified="2017-08-30" version="1">MSLRREVLKCFKNLHRTREIVFNGDVRALQKGREKINEEFKKNKDVQELATINELIRFSEEVEKELRTTVVQAREIKPGVFQANIRPDTLKLDNIPYKDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1KNG3</accession>
    <name>A0A1Y1KNG3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Inosine/uridine-preferring nucleoside hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_09011</name>
        <name evidence="4" type="ORF">PPYR_12561</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
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        <lineage>
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            <taxon>Metazoa</taxon>
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            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
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            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
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            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IUNH family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01080880">
        <property type="protein sequence ID" value="JAV62011.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0792941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1KNG3"/>
    <dbReference type="FunCoup" id="A0A1Y1KNG3">
        <property type="interactions" value="35"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1KNG3"/>
    <dbReference type="OrthoDB" id="432381at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016799">
        <property type="term" value="F:hydrolase activity, hydrolyzing N-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Ribonucleoside hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001910">
        <property type="entry name" value="Inosine/uridine_hydrolase_dom"/>
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        <property type="entry name" value="IUN_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036452">
        <property type="entry name" value="Ribo_hydro-like"/>
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        <property type="entry name" value="SI:CH211-201H21.5"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SI:CH211-201H21.5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="7"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="JAV62011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0792941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0798018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="317" mass="35273" checksum="5954D246E5DF4815" modified="2017-08-30" version="1">MLEIKHIIIDTDPGIDDLHAILMFLAAEKRNEVKIVAITVTAGNTDVNNGCRNVVSLLEKACRTDIPVYKGASKNLISEDCDFLQYYGRDGLGNTGYANNANLDILRDEPSSLAIRRLVKENRGLITLVCLGPLTNIALAAKTDDDFYMNLKEIFIMGGTIRGKGNVTLMAEFNFYFDPESVYSFLHTVTCPTTILPFEPVLEVALPATWRFEVLPNLTPEMKFLTAAEKSFYKFKNGGGGKDVWTSADGCLALIVLHPEAVLRSCEYHMSIELHGKRTRGQCILDHTKERKSNVTVVEEISQELLVNALIETHSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1KQ68</accession>
    <name>A0A1Y1KQ68_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_05589</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01076914">
        <property type="protein sequence ID" value="JAV63552.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
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        <property type="protein sequence ID" value="KAB0801235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="interactions" value="1176"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1KQ68"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0005096">
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
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    <dbReference type="PANTHER" id="PTHR46005">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 190"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FF_RHG35_4th"/>
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    </dbReference>
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        <property type="entry name" value="Ras"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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    </dbReference>
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        <property type="entry name" value="FF"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PG1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="FF" evidence="5">
        <location>
            <begin position="433"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="PG1 pseudoGTPase" evidence="6">
        <location>
            <begin position="600"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="domain" description="PG2 pseudoGTPase" evidence="7">
        <location>
            <begin position="786"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="4">
        <location>
            <begin position="1457"/>
            <end position="1666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="954"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1051"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1207"/>
            <end position="1332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1364"/>
            <end position="1460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1051"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1220"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1245"/>
            <end position="1260"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1293"/>
            <end position="1306"/>
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    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1322"/>
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        </location>
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        <location>
            <begin position="1376"/>
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            <begin position="1395"/>
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        <location>
            <begin position="1412"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51676"/>
        </source>
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        <source>
            <dbReference type="PROSITE" id="PS51852"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="JAV63552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0801235.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1675" mass="191005" checksum="0164C731B3B3F126" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1KRG8</accession>
    <name>A0A1Y1KRG8_PHOPY</name>
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        <recommendedName>
            <fullName evidence="5">Serpin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_07749</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
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        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the serpin family.</text>
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        <property type="protein sequence ID" value="KAB0799869.1"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045861">
        <property type="term" value="P:negative regulation of proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="Serine protease inhibitor (serpin) 16"/>
        <property type="match status" value="1"/>
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    </dbReference>
    <dbReference type="Gene3D" id="2.30.39.10">
        <property type="entry name" value="Alpha-1-antitrypsin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.497.10">
        <property type="entry name" value="Antithrombin, subunit I, domain 2"/>
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    </dbReference>
    <dbReference type="Gene3D" id="2.10.310.10">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Serpin_sf"/>
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    <dbReference type="InterPro" id="IPR042178">
        <property type="entry name" value="Serpin_sf_1"/>
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        <property type="entry name" value="Serpin_sf_2"/>
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    <dbReference type="PANTHER" id="PTHR11461:SF342">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR 28DC"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SERINE PROTEASE INHIBITOR, SERPIN"/>
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        <property type="match status" value="2"/>
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        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033291711" description="Serpin domain-containing protein" evidence="4">
        <location>
            <begin position="19"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="Serpin" evidence="5">
        <location>
            <begin position="61"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="JAV62770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0799869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="531" mass="59678" checksum="C08AA38002A78183" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1KU63</accession>
    <name>A0A1Y1KU63_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Isocitrate dehydrogenase [NAD] subunit, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_12441</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01075759">
        <property type="protein sequence ID" value="JAV63971.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0795602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1KU63"/>
    <dbReference type="FunCoup" id="A0A1Y1KU63">
        <property type="interactions" value="1835"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1KU63"/>
    <dbReference type="OrthoDB" id="10261637at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000001">
        <property type="entry name" value="Isocitrate dehydrogenase [NAD] subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004434">
        <property type="entry name" value="Isocitrate_DH_NAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00175">
        <property type="entry name" value="mito_nad_idh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835">
        <property type="entry name" value="DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835:SF42">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NAD] SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3 6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="7">
        <location>
            <begin position="40"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="JAV63971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0795602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="377" mass="41147" checksum="8B4B4C59B8F36F5D" modified="2017-08-30" version="1">MSLIRINPLRILNQVPTAIFTRNIHVTPAAATLTPRQENRVRCTLIPGDGVGPELVYAVQEVFKAAAVPVDFESFFFSEVNPTLSAPIDQVANSISKNKVCLKGILATPDYSRTGELQTLNMKLRNELDLYANVVHVKSLPGVRSRHTGVDCIVIREQTEGEYSALEHESVKGVVECLKIVTATKSERIAKFAFDYATKNKRKKVTAVHKANIMKLGDGLFLKCCEQTSKLYPKIEFEKLIVDNCTMQMVSRPQQFDVMVTPNLYGNIIDNLGAGLVGGAGVVAGASYSADCVVFEPGARHTFAEGVGKNIANPTAMILCAANLLNHVNLGSYGEMIKNAVSKVLHDGKVRTKDIGGQSNTQEFTYAIIYNLKPVST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1L1E9</accession>
    <name>A0A1Y1L1E9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PPYR_03099</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNAP-25 family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01072729">
        <property type="protein sequence ID" value="JAV65426.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1L1E9"/>
    <dbReference type="FunCoup" id="A0A1Y1L1E9">
        <property type="interactions" value="862"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1L1E9"/>
    <dbReference type="OrthoDB" id="18679at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031629">
        <property type="term" value="P:synaptic vesicle fusion to presynaptic active zone membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016082">
        <property type="term" value="P:synaptic vesicle priming"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15856">
        <property type="entry name" value="SNARE_SNAP29C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15887">
        <property type="entry name" value="SNARE_SNAP29N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000041">
        <property type="entry name" value="Synaptosomal-associated protein 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19305">
        <property type="entry name" value="SYNAPTOSOMAL ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19305:SF9">
        <property type="entry name" value="SYNAPTOSOMAL-ASSOCIATED PROTEIN 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12352">
        <property type="entry name" value="V-SNARE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="6">
        <location>
            <begin position="47"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="6">
        <location>
            <begin position="185"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="123"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="158"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="JAV65426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0791299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="243" mass="27865" checksum="878EBEAFB2ABD925" modified="2017-08-30" version="1">MSGHKYIGNNKLFDDVDDETFLRNSRHSYNPPPSFEEQKQSFIERKQEIEDRTIKSTERSISLLRDSEQVGIATAEELMRQREQLERTDKRLDEINQTLRFSQKHINGIKSVFSSLKSYISGRNDSSPSISTGSSNTQTTNSTIIENKVSEYDRYENHPTTRLRNPEPDSFQQGSSSKNFSARLDANLQEMHSSISKLKGLASDLSYEIDSQNDLIGDIIEKTDVADVTIVKQNKEMHRILQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1L3H6</accession>
    <name>A0A1Y1L3H6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Annexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_11465</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
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                <person name="Al-Wathiqui N."/>
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                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
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            <dbReference type="DOI" id="10.1038/srep38556"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
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            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">1611_PpyrPB1</strain>
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        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
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        </source>
    </reference>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="298" mass="34943" checksum="ABCABA12ED6898C9" modified="2017-08-30" version="1">MWSGKHDPKEDARALRAAGGNEDAIIKIITKRTNDYIQKICEQYKLMYRKDLISELICTLGEDVKEVIIALMIPRYDYYAIQLKKILTEEEVNLTAIVEIVCPLFDYERAGVEDAYRRIYANVLACQSGDDKEDTLGIDMKRANVPWWARELFKSIFNVKRYAYLRDGSKPARYRAQQLNCSIEYGDGIRTLIYILFQHHKPERDRILGAYREEYGNLEDDIRENFFDIQQEVLLAILRCVKAPSLFLENCLLDKPEDHTTLIRIVVTRSERNYRTFSDFIKYRTSGSLQKWLLAIVQ</sequence>
</entry>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
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                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
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                <consortium name="Photinus pyralis genome working group"/>
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                <person name="Sander Lower S.E."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <tissue evidence="7">Whole body</tissue>
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        <text evidence="3">Belongs to the serpin family.</text>
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<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
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            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
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                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
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                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
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                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
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                <person name="Shigenobu S."/>
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                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">1611_PpyrPB1</strain>
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    </evidence>
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        <source>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Peptidoglycan-recognition protein probably involved in innate immunity by binding to peptidoglycans (PGN) of bacteria and activating the prophenoloxidase (proPO) cascade immune response. Binds to 1,3-beta-D-glucan and PGN.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01057718">
        <property type="protein sequence ID" value="JAV72123.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1LES5"/>
    <dbReference type="FunCoup" id="A0A1Y1LES5">
        <property type="interactions" value="45"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1LES5"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042834">
        <property type="term" value="F:peptidoglycan binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06583">
        <property type="entry name" value="PGRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.80.10:FF:000001">
        <property type="entry name" value="Peptidoglycan recognition protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.80.10">
        <property type="entry name" value="Peptidoglycan recognition protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036505">
        <property type="entry name" value="Amidase/PGRP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002502">
        <property type="entry name" value="Amidase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017331">
        <property type="entry name" value="Peptidoglycan_recognition"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015510">
        <property type="entry name" value="PGRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006619">
        <property type="entry name" value="PGRP_domain_met/bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11022">
        <property type="entry name" value="PEPTIDOGLYCAN RECOGNITION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11022:SF77">
        <property type="entry name" value="PEPTIDOGLYCAN-RECOGNITION PROTEIN LB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01510">
        <property type="entry name" value="Amidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037945">
        <property type="entry name" value="PGRPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00644">
        <property type="entry name" value="Ami_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00701">
        <property type="entry name" value="PGRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55846">
        <property type="entry name" value="N-acetylmuramoyl-L-alanine amidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 7" id="KW-0391">Immunity</keyword>
    <keyword evidence="2 7" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033750814" description="Peptidoglycan-recognition protein" evidence="9">
        <location>
            <begin position="16"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidoglycan recognition protein family" evidence="11">
        <location>
            <begin position="22"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetylmuramoyl-L-alanine amidase" evidence="10">
        <location>
            <begin position="33"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="20"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="59"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00057187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR037945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR037945-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="JAV72123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAB0791528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="200" mass="22735" checksum="5AF20418D694066B" modified="2017-08-30" version="1">MQSWLIFVFGLGVLGQGEMCDFELVTREEWGARPPTDVQTMQDPVPYVIIHHTYQPPACSSSEDCIKAMRWMQDFHQIDRKWNDIGYNFVIGGDGKAYTGRGWSVVGAHSPSYNNQSIGISLIGDWRVELPPPKQIETARKVIDCGVQTGKIRPDYKLFGHQQVRQGTECPGQRLLDEISTWDHFSKTPPFVWVPNEIPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LMJ5</accession>
    <name>A0A1Y1LMJ5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein sleepless</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_12524</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01051490">
        <property type="protein sequence ID" value="JAV74850.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01051489">
        <property type="protein sequence ID" value="JAV74851.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01051488">
        <property type="protein sequence ID" value="JAV74854.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01051487">
        <property type="protein sequence ID" value="JAV74855.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01051486">
        <property type="protein sequence ID" value="JAV74857.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01051485">
        <property type="protein sequence ID" value="JAV74859.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01051483">
        <property type="protein sequence ID" value="JAV74861.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01051481">
        <property type="protein sequence ID" value="JAV74862.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01051480">
        <property type="protein sequence ID" value="JAV74863.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01051479">
        <property type="protein sequence ID" value="JAV74865.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01051478">
        <property type="protein sequence ID" value="JAV74868.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01051477">
        <property type="protein sequence ID" value="JAV74869.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01051476">
        <property type="protein sequence ID" value="JAV74871.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0792904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1LMJ5"/>
    <dbReference type="InParanoid" id="A0A1Y1LMJ5"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011907405" description="Protein sleepless" evidence="1">
        <location>
            <begin position="23"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="JAV74862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0792904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="102" mass="11556" checksum="12E837B324FCD02F" modified="2017-08-30" version="1">MIAMKKFVACFLFLLLIGTGLTLKCYKYHCSGDCWSLDEPYHEKLRVKEECTGATDLCAVSLPVKIHGPIYRGCTSDKNFCDTNHPPMYKCYTCNEDLCNSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1LNQ7</accession>
    <name>A0A1Y1LNQ7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mago nashi</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_05133</name>
        <name evidence="6" type="ORF">PPYR_08123</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mago nashi family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01053715">
        <property type="protein sequence ID" value="JAV73970.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1LNQ7"/>
    <dbReference type="FunCoup" id="A0A1Y1LNQ7">
        <property type="interactions" value="2129"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1LNQ7"/>
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        <property type="project" value="InterPro"/>
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        <source>
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        </source>
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            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0797129.1"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAB0802947.1"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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</entry>
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    <accession>A0A1Y1LPZ2</accession>
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    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
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    </reference>
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        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
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        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01055266">
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        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="EMBL" id="JAV73057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0790309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="164" mass="19441" checksum="19DDFDD7C0197E28" modified="2017-08-30" version="1">MHFTFANLFNEIDKLKKISKFLQEKGWDKSCLKKRKCLLKIYFAMKYRSHPTKESIENLRLQLQKVQFDDLYNGTLLHISPIYALAHSLKFRSRMSHSHFTKVGCSKHLSLRIANVLFPAVSPDFIAPIIQKYLKKKAFVKLFKQINQQHFCFVTIEHLFRSLH</sequence>
</entry>
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    <accession>A0A1Y1LQL2</accession>
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        <name evidence="3" type="ORF">PPYR_12405</name>
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        <name type="scientific">Photinus pyralis</name>
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            <taxon>Pterygota</taxon>
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            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
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            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
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                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01049440">
        <property type="protein sequence ID" value="JAV75964.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <location>
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        <location>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="JAV75964.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAB0795566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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</entry>
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    <accession>A0A1Y1LX13</accession>
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            <fullName evidence="2">Pacifastin domain-containing protein</fullName>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
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                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01044866">
        <property type="protein sequence ID" value="JAV78077.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01044865">
        <property type="protein sequence ID" value="JAV78079.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1LX13"/>
    <dbReference type="InParanoid" id="A0A1Y1LX13"/>
    <dbReference type="OrthoDB" id="6743812at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030414">
        <property type="term" value="F:peptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008037">
        <property type="entry name" value="Pacifastin_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05375">
        <property type="entry name" value="Pacifastin_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011907417" description="Pacifastin domain-containing protein" evidence="1">
        <location>
            <begin position="45"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Pacifastin" evidence="2">
        <location>
            <begin position="49"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="JAV78079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0792761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="117" mass="12925" checksum="9E542CDCFFC0ABEB" modified="2017-08-30" version="1">MSLLVQFTIKELYINLSSPMSKQSNTMKVQLLVLAVFCIACAFASDEFVCQEGVPYKENECNNCNCNNGHLACTLMACSGERSAELRKCEVGTKTKVDCNDCECVKNMGTICTNRKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1M0E6</accession>
    <name>A0A1Y1M0E6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein prenyltransferase alpha subunit repeat-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PPYR_04684</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein prenyltransferase subunit alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01045547">
        <property type="protein sequence ID" value="JAV77755.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1M0E6"/>
    <dbReference type="FunCoup" id="A0A1Y1M0E6">
        <property type="interactions" value="430"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1M0E6"/>
    <dbReference type="OrthoDB" id="5358702at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008318">
        <property type="term" value="F:protein prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.120">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002088">
        <property type="entry name" value="Prenyl_trans_a"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE ALPHA SUBUNIT/RAB GERANYLGERANYL TRANSFERASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129:SF3">
        <property type="entry name" value="PROTEIN PRENYLTRANSFERASE ALPHA SUBUNIT REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01239">
        <property type="entry name" value="PPTA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48439">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51147">
        <property type="entry name" value="PFTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="JAV77755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0802498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="436" mass="51582" checksum="8C2F8444D6A5C5B0" modified="2017-08-30" version="1">MEEDNAMYEKILIDIKNLIRSDPNLKDFCIVPINENKNKSPVLYEEHNLGLELWCVKYVYAYLYKQLFKLRRLLSKNRLIQQKSEEIDKYLISALLIHPEVATFWNMRRELVEYGVINLDIELLLTKLVLSNKSKSNEAFAYRKWIVSKLMKGIYKHDVVSTLALLNQEFTVTEMAAQNSPNNYHAWNHRMWCLQSAFVKHDFADTPMYLNLVFEQLDFSIRWIQSHISEHAGFHYRQYLLKCVLNSCCSVSERTGKIRCLLETFAHIKACDDEGFVQQLLGRSSTCVNRSMVNFILLLLEDLFYFMDQLNELFPGHEAVWYHRRFLIFHILQIAHEYHNVVWFRNVNVSGLMLNSNDNIINVDSGLSDTKYPKLPKYELDAVESSYLYKILLKFEFEHIQGNSLSKCIDAQRELARRHEKWLHFILCFNKSNSFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1M2J8</accession>
    <name>A0A1Y1M2J8_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_00543</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01042013">
        <property type="protein sequence ID" value="JAV80072.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0803573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1M2J8"/>
    <dbReference type="InParanoid" id="A0A1Y1M2J8"/>
    <dbReference type="OrthoDB" id="6677432at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="JAV80072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0803573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="123" mass="13533" checksum="5BD29B727F11526D" modified="2017-08-30" version="1">MDRQKSDIFALDKSVNSGMEILSVGGTRFGKLNRIRSTTSNVFPVGCMGTVESPRAETPRMPVNENNSFAKPSPRPETVIEEVTSPREATSKRNPVTGEGVNSSDMPKASSSRRKLEQPKFIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2023-09-13" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1M7G7</accession>
    <name>A0A1Y1M7G7_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_14625</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01038926">
        <property type="protein sequence ID" value="JAV81481.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1M7G7"/>
    <dbReference type="InParanoid" id="A0A1Y1M7G7"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="JAV81481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0792666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="100" mass="11099" checksum="225F7F9D712BC756" modified="2017-08-30" version="1">MDVVTCAGATNNRRNATLSRRITIGLSSRVFWFISLATIYTCRSSEFVGKTDLIRVKRNFLLIPKIPGFLSMLQTGLRNEGRSQRAKNLVLNGGGERVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1MGI1</accession>
    <name>A0A1Y1MGI1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Solute carrier family 12 member 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PPYR_05872</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">1611_PpyrPB1</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">1611_PpyrPB1</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
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        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC12A transporter family.</text>
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        <property type="protein sequence ID" value="JAV84763.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
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        <property type="project" value="TreeGrafter"/>
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</entry>
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        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
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                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
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                <person name="Weng J.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
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                <person name="Sander Lower S.E."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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        </source>
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    <comment type="subunit">
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        <text evidence="3 13">Belongs to the tubulin family.</text>
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    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01162">
        <property type="entry name" value="ALPHATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 13" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="14">
        <location>
            <begin position="50"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="15">
        <location>
            <begin position="249"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="JAV84586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAB0790397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="442" mass="49670" checksum="2C72F91816305CCF" modified="2017-08-30" version="1">MPGHKEIIQLHVGQAGVQIASACWELYCLEHGIQPNGQLYDYRNVSPDSFNAFFGMSAAGKCVPRILMIDLEPSVIDEIRTGHYRYLFHPECLITGKEDAANNFARGMYSIGREMIELALDRIRKVADDCNSLQGFILYRAFGGGTGSGFSTLLLERLCRDYGRKVKLEFAVYPAPHISPIIVEPYNTLLTTHGTLDYEDVAFVLDNEAVYNILARSLDVPRPTYTNLNRLLAQVVSTITSSLRFEGALNIDLNEFQTNLVPYPRIHFPLITYAPMLPCTKAYHEQLSVAQLTNSCFEPANQMINCDPRTGKYICCCLLYRGDVTPTDVNSAIVNIKSKRSILFVDWCPTGFKVGINYQPPTTVPGGDLAAVHRAVTMVSNSTAIKESWKVITHKFSLMYKKRAFVHHYVGEGMEEGEFEEAREDITALQLDYKEVEIDSVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1MPT5</accession>
    <name>A0A1Y1MPT5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Ras GTPase-activating protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PPYR_04650</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01024959">
        <property type="protein sequence ID" value="JAV87669.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01024957">
        <property type="protein sequence ID" value="JAV87672.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000002">
        <property type="protein sequence ID" value="KAB0802464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1MPT5"/>
    <dbReference type="FunCoup" id="A0A1Y1MPT5">
        <property type="interactions" value="2128"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1MPT5"/>
    <dbReference type="OrthoDB" id="1562946at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048468">
        <property type="term" value="P:cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11788">
        <property type="entry name" value="SH3_RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000402">
        <property type="entry name" value="Uncharacterized protein, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039360">
        <property type="entry name" value="Ras_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023152">
        <property type="entry name" value="RasGAP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035652">
        <property type="entry name" value="RasGAP_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194:SF146">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00509">
        <property type="entry name" value="RAS_GTPASE_ACTIV_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="1 5" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH2" evidence="7">
        <location>
            <begin position="60"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="8">
        <location>
            <begin position="157"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="7">
        <location>
            <begin position="229"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="9">
        <location>
            <begin position="360"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="10">
        <location>
            <begin position="465"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GAP" evidence="11">
        <location>
            <begin position="636"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="JAV87672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAB0802464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="929" mass="104614" checksum="F111795B4CBFEFA1" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1MRH9</accession>
    <name>A0A1Y1MRH9_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_08774</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01023578">
        <property type="protein sequence ID" value="JAV88294.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1MRH9"/>
    <dbReference type="InParanoid" id="A0A1Y1MRH9"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="293"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="59"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="199"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="296"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="JAV88294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0797781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="347" mass="39932" checksum="E80DD8FE509F4891" modified="2017-08-30" version="1">MENLQSYSLTDSDFIPQRDTETTEWFEDASSNADWIDNFSDPISAASLGDESYNPLESYENLCQKNKNLEQRWQDVEQKYESLLRERERQSLHLLHEQEKVQKYQQKLQYIKSNCDVVNQLKEKYLSAKSMLSNTKDNTVSVEKSCQTISGLELQNAINYEKDVIVVVKRSELQVMKETLGKLKGLVDNYRVSASNAEKSKYETEIRQLHNTIANLKDTVSKKSYYLDIAKQNMVDRKTFESVQKESESLKRIVVKMEKRLREMCSPMHSFPVLNDEENAFVEQIIRAYHQEKPKLNPKLHKAGNSTLHRRSSSSSDDSKDIGAFGAASNAKFIPVINLPNHSSGDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1MRY3</accession>
    <name>A0A1Y1MRY3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Dihydropyrimidine dehydrogenase [NADP(+)]</fullName>
            <shortName evidence="18">DHPDHase</shortName>
            <shortName evidence="18">DPD</shortName>
            <ecNumber evidence="18">1.3.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Dihydrothymine dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Dihydrouracil dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">PPYR_12770</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="21 22" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">1611_PpyrPB1</strain>
            <tissue evidence="21">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">1611_PpyrPB1</strain>
            <tissue evidence="21">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17 18">
            <text>5,6-dihydrouracil + NADP(+) = uracil + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18093"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15901"/>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.3.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 18">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 18">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="18">Binds 4 [4Fe-4S] clusters. Contains approximately 16 iron atoms per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 18">Amino-acid biosynthesis; beta-alanine biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Pyrimidine metabolism; UMP biosynthesis via de novo pathway.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 18">Belongs to the dihydropyrimidine dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.2" evidence="18"/>
    <dbReference type="EMBL" id="GEZM01023413">
        <property type="protein sequence ID" value="JAV88401.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1MRY3"/>
    <dbReference type="FunCoup" id="A0A1Y1MRY3">
        <property type="interactions" value="236"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1MRY3"/>
    <dbReference type="UniPathway" id="UPA00070"/>
    <dbReference type="UniPathway" id="UPA00131"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004152">
        <property type="term" value="F:dihydroorotate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017113">
        <property type="term" value="F:dihydropyrimidine dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002058">
        <property type="term" value="F:uracil binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019483">
        <property type="term" value="P:beta-alanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006210">
        <property type="term" value="P:thymine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006212">
        <property type="term" value="P:uracil catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02940">
        <property type="entry name" value="DHPD_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1060.10:FF:000007">
        <property type="entry name" value="Dihydropyrimidine dehydrogenase [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000027">
        <property type="entry name" value="Dihydropyrimidine dehydrogenase [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.20:FF:000023">
        <property type="entry name" value="Dihydropyrimidine dehydrogenase [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000061">
        <property type="entry name" value="Dihydropyrimidine dehydrogenase [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="entry name" value="Alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005720">
        <property type="entry name" value="Dihydroorotate_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001295">
        <property type="entry name" value="Dihydroorotate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028261">
        <property type="entry name" value="DPD_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43073">
        <property type="entry name" value="DIHYDROPYRIMIDINE DEHYDROGENASE [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43073:SF2">
        <property type="entry name" value="DIHYDROPYRIMIDINE DEHYDROGENASE [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01180">
        <property type="entry name" value="DHO_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14691">
        <property type="entry name" value="Fer4_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14697">
        <property type="entry name" value="Fer4_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46548">
        <property type="entry name" value="alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00912">
        <property type="entry name" value="DHODEHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 18" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="12 18" id="KW-0274">FAD</keyword>
    <keyword evidence="7 18" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8 18" id="KW-0288">FMN</keyword>
    <keyword evidence="15 18" id="KW-0408">Iron</keyword>
    <keyword evidence="16" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13 18" id="KW-0521">NADP</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14 18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="19">
        <location>
            <begin position="939"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="19">
        <location>
            <begin position="973"/>
            <end position="1002"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
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        <source>
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    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00052371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU364041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="JAV88401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAB0793150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1024" mass="111050" checksum="82A136B7F2821540" modified="2017-08-30" version="1"> </sequence>
</entry>
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    <accession>A0A1Y1N5F0</accession>
    <name>A0A1Y1N5F0_PHOPY</name>
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    </protein>
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    <organism evidence="7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
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        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Elateroidea</taxon>
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        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="8">1611_PpyrPB1</strain>
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        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
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        </source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="441" mass="49534" checksum="9F3261639D51F3C7" modified="2017-08-30" version="1">MIPPLAPGQLDEQQNMVGWKNTFNMRQVTLMNLAASHLGARNGNLTYMSTGCITSPTKSLDLLRKNLQSAINKDIDNVIKKYLEKFFQPAVANIRMNLGKNSVNEELIKNVCQQMLEEAKLMYKVSPSSRDSSPYDYSDSEGGSLIDSRIEQVSPVHYKRKESDTDSETGYVINHKRYKAKTVKCDNMSQKLPDKREGPKWDPERIHPNTLFIMGARANKVLGFGQTRGRLYVRHPEVLRYCSDPEDKEWLASKNLMPPSGGRAYLMLLEDIQELALNDDYRNNPNLQLNELQGFEAPPFMLNKIKLFLEQVRTDKRQNCDLFEYQPSQCMTPIDSAPSTPSDTLQALDTHSLSSKQSDINSLINIPETSPGSNNSFMSGPYTQSPARTSNSLSPHMLIGVTVDGSNNNTSVLSLVENLHNDKLLSNLLSVHGSTENSQEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1N9B9</accession>
    <name>A0A1Y1N9B9_PHOPY</name>
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            <fullName evidence="10">Ras-related protein Rac1</fullName>
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    </protein>
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    <organism evidence="7">
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    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
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                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01012962">
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        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000327044">
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    <dbReference type="GO" id="GO:0005525">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0488">Methylation</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0581">Phagocytosis</keyword>
    <keyword evidence="6" id="KW-0636">Prenylation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="JAV92846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0793148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="192" mass="21383" checksum="B2731F90F252055A" modified="2017-08-30" version="1">MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDGKPINLGLWDTAGQEDYDRLRPLSYPQTDVFLICFSLVNPASFENVRAKWYPEVRHHCPSTPIILVGTKLDLRDDRATIEKLKDKKLAPITYPQGLAMAKEISAVKYLECSALTQKGLKTVFDEAIRAVLCPVMQVKPKRKCIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1NAF8</accession>
    <name>A0A1Y1NAF8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Dual specificity protein phosphatase</fullName>
            <ecNumber evidence="7">3.1.3.16</ecNumber>
            <ecNumber evidence="7">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PPYR_05885</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">1611_PpyrPB1</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="7"/>
    <dbReference type="EC" id="3.1.3.48" evidence="7"/>
    <dbReference type="EMBL" id="GEZM01011145">
        <property type="protein sequence ID" value="JAV93635.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000003">
        <property type="protein sequence ID" value="KAB0801531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1NAF8"/>
    <dbReference type="FunCoup" id="A0A1Y1NAF8">
        <property type="interactions" value="175"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1NAF8"/>
    <dbReference type="OrthoDB" id="253091at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033549">
        <property type="term" value="F:MAP kinase phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008138">
        <property type="term" value="F:protein tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043409">
        <property type="term" value="P:negative regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14515">
        <property type="entry name" value="DUSP3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020405">
        <property type="entry name" value="Atypical_DUSP_subfamA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45682">
        <property type="entry name" value="AGAP008228-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45682:SF1">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01908">
        <property type="entry name" value="ADSPHPHTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01909">
        <property type="entry name" value="ADSPHPHTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="8">
        <location>
            <begin position="58"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="9">
        <location>
            <begin position="129"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate" evidence="6">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR620405-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="JAV93635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAB0801531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="214" mass="24197" checksum="98B0683ABD18F871" modified="2017-08-30" version="1">MTYHSQLTTNKMWRESVYSGTLRPKSTDGLTGSMLNDLLDSLSITVRDTTRSLSHIHSVNQISDGLFLGDKYAAKDKTFLIQNGFTHIVNAAEGIDEYQVNTCQRYYTPLKIKYLGIPGHDRPSWNISVYFKEAAMFIDNAVKSGGKVLVHCVVGISRSATLVIAYFMIYHNMNAAQALQHVFRRRRVFPNAGFLHHLAHLNSLLSIKRPSYTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1NB17</accession>
    <name>A0A1Y1NB17_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Polyadenylate-binding protein</fullName>
            <shortName evidence="9">PABP</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PPYR_13696</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Binds and protects the poly(A) tail of mRNA with or without an AU-rich element (ARE) and prevents mRNA deadenylation. Stimulates the translation of mRNAs to which it is bound during early development.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Binds the poly(A) tail of mRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Interacts with dazl in an RNA-independent manner. The C-terminus can self-associate and also interact with the C-terminus of pabpc1, independently of RNA. RRM 1 and RRM 2 interact with both eif4g1 and paip1, and the C-terminus also interacts with paip1. Prior to oocyte maturation, found in a complex with dazl and pum2 proteins and spdy1 mRNA; pum2 dissociates from the complex during maturation. Interacts with the translation termination factor sup35/erf3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the polyadenylate-binding protein type-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01010785">
        <property type="protein sequence ID" value="JAV93835.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0794076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1NB17"/>
    <dbReference type="FunCoup" id="A0A1Y1NB17">
        <property type="interactions" value="1393"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1NB17"/>
    <dbReference type="OrthoDB" id="19742at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12378">
        <property type="entry name" value="RRM1_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12379">
        <property type="entry name" value="RRM2_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12380">
        <property type="entry name" value="RRM3_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12381">
        <property type="entry name" value="RRM4_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1900.10:FF:000001">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000003">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000021">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000042">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000049">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1900.10">
        <property type="entry name" value="c-terminal domain of poly(a) binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036053">
        <property type="entry name" value="PABP-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006515">
        <property type="entry name" value="PABP_1234"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002004">
        <property type="entry name" value="PABP_HYD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034364">
        <property type="entry name" value="PABP_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045305">
        <property type="entry name" value="RRM2_I_PABPs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01628">
        <property type="entry name" value="PABP-1234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24012">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00658">
        <property type="entry name" value="MLLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00517">
        <property type="entry name" value="PolyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63570">
        <property type="entry name" value="PABC (PABP) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51309">
        <property type="entry name" value="PABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 8 9" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="11"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="99"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="FHA" evidence="10">
        <location>
            <begin position="120"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="192"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="296"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="PABC" evidence="12">
        <location>
            <begin position="532"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00057784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00066197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="JAV93835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAB0794076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="619" mass="69455" checksum="25F59C43A94D3E8B" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1NGP6</accession>
    <name>A0A1Y1NGP6_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_02662</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01003575">
        <property type="protein sequence ID" value="JAV96715.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01003574">
        <property type="protein sequence ID" value="JAV96716.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01003573">
        <property type="protein sequence ID" value="JAV96717.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01003572">
        <property type="protein sequence ID" value="JAV96718.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0805692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1NGP6"/>
    <dbReference type="InParanoid" id="A0A1Y1NGP6"/>
    <dbReference type="OrthoDB" id="6514241at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028019">
        <property type="entry name" value="DUF4508"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16260:SF3">
        <property type="entry name" value="CHROMOSOME 14 OPEN READING FRAME 119-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16260">
        <property type="entry name" value="SIMILAR TO 1700123O20RIK PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14969">
        <property type="entry name" value="DUF4508"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="JAV96718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0805692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="128" mass="15052" checksum="8F9DBF8B4C24414B" modified="2017-08-30" version="1">MTNISAEAQIRYLIQWFNEWSELQRSDFLPILAEKYSNKVYVNGIVNHMSNVNCQDKPMSLFECRIKLFKEWFGHWNPEQRDNFLTKISDIDEIFAAKLNVELQQGLENGEILNENHNATNGEDLLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1NHL1</accession>
    <name>A0A1Y1NHL1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Derlin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PPYR_12557</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">1611_PpyrPB1</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Endoplasmic reticulum membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the derlin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01002058">
        <property type="protein sequence ID" value="JAV97393.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000009">
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="P:ERAD pathway"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="entry name" value="Derlin"/>
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        <property type="entry name" value="Rhomboid-like_sf"/>
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    <dbReference type="PANTHER" id="PTHR11009">
        <property type="entry name" value="DER1-LIKE PROTEIN, DERLIN"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="53"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="99"/>
            <end position="132"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="152"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="216"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008917"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="JAV97393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0792937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="248" mass="28994" checksum="66E5B72041F091D8" modified="2017-08-30" version="1">MAYQTLKQEYLNMPPVTRAYTTACVITSLAVQLELTSPFQLYFNPILIYKGQIWRLITTFLFFGTFGFNFFFNMIFTYRYCRMLEEGSFRNRTSDFVTMFLFGGGLMIAIGFSVNLLFLGQAFTIMLVYIWSRRNPFFRMNFFGLVNFQAPYLPWALLSFSVLLGNTVYIDLIGIVVGHIYYFIEDVFPNQRGGFRILKTPTILKTIFDNHTDDPDYVPLPEERPGGFDWGQNRQDENQAPPQQEDRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1NK85</accession>
    <name>A0A1Y1NK85_PHOPY</name>
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        <recommendedName>
            <fullName evidence="7">PITH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_01754</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="GEZM01002970">
        <property type="protein sequence ID" value="JAV97025.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000001">
        <property type="protein sequence ID" value="KAB0804784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="OrthoDB" id="2121326at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Glutaredoxin"/>
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    </dbReference>
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        <property type="entry name" value="PITH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR46115">
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="THIOREDOXIN"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="PITH" evidence="3">
        <location>
            <begin position="113"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="JAV97025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0804784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="285" mass="31308" checksum="F4E59532443F278A" modified="2017-08-30" version="1">MTSIRVINNEAHFVAELANATSRLVVADFTASWCGPCQRIAPVFQQLSTKYGKAIFLKIDVDKCQEVAAAQGVSAMPTFIFYRNKTKIDSVQGADPTALENKIQQYYGSEDGDEAEGLPGHMDLSPFILKANCECLNENDDHPFAHCLQAGGGFLQSDCDEQLILSISFNQGVKIHSLRIKAPSDKGPKNIKIFINQPHTLDFDVATSYKSVQDVELTPADLDGSSVNLRYVKFQNVQNIQFFIKDNQSGGEVTQIDHFAIIGSPISTTNMGDFKRVAGKKGESH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1NKM8</accession>
    <name>A0A1Y1NKM8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sulfotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PPYR_11421</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
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            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">1611_PpyrPB1</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfotransferase 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01003671">
        <property type="protein sequence ID" value="JAV96636.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01003663">
        <property type="protein sequence ID" value="JAV96645.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0794582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1NKM8"/>
    <dbReference type="InParanoid" id="A0A1Y1NKM8"/>
    <dbReference type="OrthoDB" id="205623at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11783">
        <property type="entry name" value="SULFOTRANSFERASE SULT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="3">
        <location>
            <begin position="44"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="JAV96636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAB0794582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="323" mass="38284" checksum="A5B85E53CBF54ABE" modified="2017-08-30" version="1">MLPIRNAKGKFGEGCVLSFGEDGTRMREGYRDYATAIENFEIRDDDIIVATFPKSGTTWTQEMVWLVKNCNNLEGSSADIHQRFPMLEGCTLQFPCKTEHWLRDSIEYLNQIKNQRFIKTHLPCSLLPNDIKYHRKTPKIIYVVRNPKDVCISYYHHFRNIVGFKGGVEDFFELFINDTILYAPYWKHVIGYYNIKHLSNVLIIKYEDMKRDLKAVIIKVQRFLESEPLTDKQLRLISQRLDFEFMKDNEFVNHQSFIDARKREIPQLTGRFMRAGCNGTYKQEMSTDQILKFDKWIEKNISNTELNDQYWFGNFNEPQHLDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1NL77</accession>
    <name>A0A1Y1NL77_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCR4-NOT transcription complex subunit 9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Cell differentiation protein RQCD1 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PPYR_09252</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="38556" last="38556">
            <title>Molecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection.</title>
            <authorList>
                <person name="Al-Wathiqui N."/>
                <person name="Fallon T.R."/>
                <person name="South A."/>
                <person name="Weng J.K."/>
                <person name="Lewis S.M."/>
            </authorList>
            <dbReference type="PubMed" id="28004739"/>
            <dbReference type="DOI" id="10.1038/srep38556"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">1611_PpyrPB1</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">1611_PpyrPB1</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">P-body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CNOT9 family.</text>
    </comment>
    <dbReference type="EMBL" id="GEZM01003813">
        <property type="protein sequence ID" value="JAV96546.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GEZM01003812">
        <property type="protein sequence ID" value="JAV96547.1"/>
        <property type="molecule type" value="Transcribed_RNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1NL77"/>
    <dbReference type="FunCoup" id="A0A1Y1NL77">
        <property type="interactions" value="1427"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A1Y1NL77"/>
    <dbReference type="OrthoDB" id="1183224at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030014">
        <property type="term" value="C:CCR4-NOT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000037">
        <property type="entry name" value="CCR4-NOT transcription complex subunit 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007216">
        <property type="entry name" value="CNOT9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12262">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04078">
        <property type="entry name" value="Rcd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0010">Activator</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0678">Repressor</keyword>
    <keyword evidence="9" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0810">Translation regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="JAV96547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAB0798259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="297" mass="33523" checksum="B47550F196B8765C" modified="2017-08-30" version="1">MSAEPSPANQTVDREKIYQWILELTNPETRENALLELSKKREVVPDLAPMLWNSFGTIAALLLEIITIYPAINPATLTAHQSNRVCNALALLQCVASHPDTRSQFLLAHVPLFLYPFLHTISKTRPFEYLRLTSLGVIGALVKTDEQEVITFLLTTEIIPLCLRIMESGSELSKTVATFILQKILLDDSGLNYICQTYDRFSHVAMILGKMVLSLAKDPSARLLKHVVRCYLRLSDNSRAREALRQCLPDQLRDTTFNTCLQEDKSTKHWLSQLLTNLETPVAPDPRQVDIPVLTSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N3ZZ42</accession>
    <name>A0A5N3ZZ42_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_15324</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01001485">
        <property type="protein sequence ID" value="KAB0790330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N3ZZ42"/>
    <dbReference type="InParanoid" id="A0A5N3ZZ42"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF9">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="530"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="834"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="235"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="835"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="857"/>
            <end position="873"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0790330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="895" mass="101459" checksum="06BC45635E3BEAEE" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N3ZZE8</accession>
    <name>A0A5N3ZZE8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_15167</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01001250">
        <property type="protein sequence ID" value="KAB0790445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N3ZZE8"/>
    <dbReference type="InParanoid" id="A0A5N3ZZE8"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF269">
        <property type="entry name" value="NUCLEASE HARBI1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="8">
        <location>
            <begin position="3"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0790445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="131" mass="15258" checksum="C5E277DF0630C801" modified="2020-02-26" version="1">MPHVIIADEAYPLMKHLLKPYRKQELNADKEYFNKRLSRARRTVECAFGILRSKWQILDKPILTHPGHADNIIKAICILHNVIIDKEGIEHNLKETQFVFQNENRQAPAGRVNNEAKVVRDNFKAYLCNNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N3ZZF5</accession>
    <name>A0A5N3ZZF5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">MD-2-related lipid-recognition domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PPYR_15223</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the intermembrane transfer of phosphatidylglycerol and phosphatidylinositol.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NPC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01001371">
        <property type="protein sequence ID" value="KAB0790408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N3ZZF5"/>
    <dbReference type="InParanoid" id="A0A5N3ZZF5"/>
    <dbReference type="OrthoDB" id="6489092at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015918">
        <property type="term" value="P:sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003172">
        <property type="entry name" value="ML_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039670">
        <property type="entry name" value="NPC2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11306">
        <property type="entry name" value="NIEMANN PICK TYPE C2 PROTEIN NPC2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11306:SF0">
        <property type="entry name" value="PHOSPHATIDYLGLYCEROL_PHOSPHATIDYLINOSITOL TRANSFER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02221">
        <property type="entry name" value="E1_DerP2_DerF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00737">
        <property type="entry name" value="ML"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024373817" description="MD-2-related lipid-recognition domain-containing protein" evidence="7">
        <location>
            <begin position="19"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="MD-2-related lipid-recognition" evidence="8">
        <location>
            <begin position="22"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0790408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="148" mass="15676" checksum="A0A09A4718A2FE4E" modified="2020-02-26" version="1">MSFQVFFIFAALVFGVFADTPYTTCTTQLNGATINHFQVNDCTTSPCQVKRGSTITLSLDIAARVNIGLNTQPSVTVAVIISGTPFPVYQSTLCSITTCPILAGTTRVIVASQTLPSTATPGTYTVRLSVVDNSQTILCAQFVLSVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A0H8</accession>
    <name>A0A5N4A0H8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PPYR_15180</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000739">
        <property type="protein sequence ID" value="KAB0790825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A0H8"/>
    <dbReference type="InParanoid" id="A0A5N4A0H8"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005911">
        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050839">
        <property type="term" value="F:cell adhesion molecule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051275">
        <property type="entry name" value="Cell_adhesion_signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640:SF154">
        <property type="entry name" value="IRREGULAR CHIASM C-ROUGHEST PROTEIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640">
        <property type="entry name" value="NEPHRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="2 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="361"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="67"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="154"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0790825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="391" mass="43682" checksum="88B7AE46F870B00E" modified="2020-02-26" version="1" fragment="single">QNEITPSRRQTNSTELDNPRTWMAISVLELTISKENHGRTLRCVAVHESYSTKSSSIEVRLDVMYVPETRLVGIPTNDIEELKDSVAVRCMVNSNPRASVTWRREGQSVAASFQELLQFSPAVRQHAGLYTCHARNQAGESPPLRFHLDVKYPPKILSVGPDRLTTAPLFTSATFECIAEGNPQPTYQWLQRYPTPSDFILERGRESKLHVPNVTYDYQGEYVCKVTNIIGGIERTVQSESIALQVVGAPQVLRHSIKPEIRVEKGESADLRVVVCADPRPRVMAWEWGSVRMEAGSTKGRFKVDDVTEEEREDCYSAALHISDADSVDSRAYYLAVENDKGKDKHAVLLYVNEPMQLSTLVTLAGGALAAFLLLVCACIYAIKTEKCCFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A0N2</accession>
    <name>A0A5N4A0N2_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Bridge-like lipid transfer protein family member 1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_14953</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000684">
        <property type="protein sequence ID" value="KAB0790866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A5N4A0N2">
        <property type="interactions" value="715"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A0N2"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048488">
        <property type="term" value="P:synaptic vesicle endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033616">
        <property type="entry name" value="BLTP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056742">
        <property type="entry name" value="BLTP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056741">
        <property type="entry name" value="BLTP1_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047104">
        <property type="entry name" value="BLTP1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31640:SF1">
        <property type="entry name" value="BRIDGE-LIKE LIPID TRANSFER PROTEIN FAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31640">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN KIAA1109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25040">
        <property type="entry name" value="BLTP1_C"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25039">
        <property type="entry name" value="BLTP1_M"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20413">
        <property type="entry name" value="BLTP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01220">
        <property type="entry name" value="FSA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Bridge-like lipid transfer protein family member 1 C-terminal" evidence="3">
        <location>
            <begin position="4249"/>
            <end position="4842"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1459"/>
            <end position="1512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2318"/>
            <end position="2343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2577"/>
            <end position="2608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2623"/>
            <end position="2647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2903"/>
            <end position="2923"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="3574"/>
            <end position="3616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="3749"/>
            <end position="3777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="3818"/>
            <end position="3837"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="4191"/>
            <end position="4224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="4465"/>
            <end position="4486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1461"/>
            <end position="1476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1486"/>
            <end position="1497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1501"/>
            <end position="1511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2325"/>
            <end position="2334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2577"/>
            <end position="2597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2630"/>
            <end position="2641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2903"/>
            <end position="2913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="3589"/>
            <end position="3603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="3768"/>
            <end position="3777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="3824"/>
            <end position="3834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="4465"/>
            <end position="4484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0790866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="4857" mass="542498" checksum="8FE440250CDEBF99" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A129</accession>
    <name>A0A5N4A129_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Transportin-3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PPYR_02835</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Importin, which transports target proteins into the nucleus. Specifically mediates the nuclear import of splicing factor serine/arginine (SR) proteins, such as RBM4, SFRS1 and SFRS2, by recognizing phosphorylated SR domains. Also mediates the nuclear import of serine/arginine (SR) protein CPSF6, independently of CPSF6 phosphorylation. The nuclear import process is regulated by the small GTPase Ran that partitions between cytoplasm and nucleus in the predominantly GDP- and GTP-bound form, respectively. Importin associates with target cargo proteins in the cytoplasm, and the competitive binding of GTP-bound Ran induces the release of cargos in the nucleus.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with (GTP-bound) Ran. Interacts with (phosphorylated) SFRS1 and SFRS2; leading to their nuclear import. Interacts with NUP62. Interacts with RBM4. Interacts with CPSF6, promoting its nuclear import.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus envelope</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A129"/>
    <dbReference type="FunCoup" id="A0A5N4A129">
        <property type="interactions" value="2644"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A129"/>
    <dbReference type="OrthoDB" id="435593at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000079">
        <property type="entry name" value="transportin-3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051345">
        <property type="entry name" value="Importin_beta-like_NTR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057941">
        <property type="entry name" value="TPR_TNPO3_IPO13_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057942">
        <property type="entry name" value="TPR_TNPO3_IPO13_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058537">
        <property type="entry name" value="TPR_TNPO3_IPO13_4th"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12363">
        <property type="entry name" value="TRANSPORTIN 3 AND IMPORTIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12363:SF42">
        <property type="entry name" value="TRANSPORTIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24138">
        <property type="entry name" value="TPR_TNPO3_IPO13_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24140">
        <property type="entry name" value="TPR_TNPO3_IPO13_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24139">
        <property type="entry name" value="TPR_TNPO3_IPO13_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="12">
        <location>
            <begin position="29"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00060097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00063116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00067328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAB0791035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="937" mass="106419" checksum="74BB6CD52D01826B" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A1S6</accession>
    <name>A0A5N4A1S6_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="51">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="51" type="ORF">PPYR_03018</name>
    </gene>
    <organism evidence="51 52">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="51 52" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="51">1611_PpyrPB1</strain>
            <tissue evidence="51">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>(2E)-butenoyl-[ACP] + NADPH + H(+) = butanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41812"/>
            <dbReference type="Rhea" id="RHEA-COMP:9627"/>
            <dbReference type="Rhea" id="RHEA-COMP:9628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78453"/>
            <dbReference type="ChEBI" id="CHEBI:78454"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:41813"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="47">
            <text>(2E)-decenoyl-[ACP] + NADPH + H(+) = decanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41864"/>
            <dbReference type="Rhea" id="RHEA-COMP:9639"/>
            <dbReference type="Rhea" id="RHEA-COMP:9640"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78467"/>
            <dbReference type="ChEBI" id="CHEBI:78468"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="47">
            <dbReference type="Rhea" id="RHEA:41865"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="31">
            <text>(2E)-dodecenoyl-[ACP] + NADPH + H(+) = dodecanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41880"/>
            <dbReference type="Rhea" id="RHEA-COMP:9643"/>
            <dbReference type="Rhea" id="RHEA-COMP:9644"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65264"/>
            <dbReference type="ChEBI" id="CHEBI:78472"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="31">
            <dbReference type="Rhea" id="RHEA:41881"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>(2E)-hexadecenoyl-[ACP] + NADPH + H(+) = hexadecanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41912"/>
            <dbReference type="Rhea" id="RHEA-COMP:9651"/>
            <dbReference type="Rhea" id="RHEA-COMP:9652"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78481"/>
            <dbReference type="ChEBI" id="CHEBI:78483"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:41913"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>(2E)-hexenoyl-[ACP] + NADPH + H(+) = hexanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41832"/>
            <dbReference type="Rhea" id="RHEA-COMP:9631"/>
            <dbReference type="Rhea" id="RHEA-COMP:9632"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78458"/>
            <dbReference type="ChEBI" id="CHEBI:78459"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="27">
            <dbReference type="Rhea" id="RHEA:41833"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="40">
            <text>(2E)-octadecenoyl-[ACP] + NADPH + H(+) = octadecanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41928"/>
            <dbReference type="Rhea" id="RHEA-COMP:9655"/>
            <dbReference type="Rhea" id="RHEA-COMP:9656"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78489"/>
            <dbReference type="ChEBI" id="CHEBI:78495"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="40">
            <dbReference type="Rhea" id="RHEA:41929"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="33">
            <text>(2E)-octenoyl-[ACP] + NADPH + H(+) = octanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41848"/>
            <dbReference type="Rhea" id="RHEA-COMP:9635"/>
            <dbReference type="Rhea" id="RHEA-COMP:9636"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78462"/>
            <dbReference type="ChEBI" id="CHEBI:78463"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="33">
            <dbReference type="Rhea" id="RHEA:41849"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="42">
            <text>(2E)-tetradecenoyl-[ACP] + NADPH + H(+) = tetradecanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41896"/>
            <dbReference type="Rhea" id="RHEA-COMP:9647"/>
            <dbReference type="Rhea" id="RHEA-COMP:9648"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78475"/>
            <dbReference type="ChEBI" id="CHEBI:78477"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="42">
            <dbReference type="Rhea" id="RHEA:41897"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>(3R)-hydroxybutanoyl-[ACP] = (2E)-butenoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:41808"/>
            <dbReference type="Rhea" id="RHEA-COMP:9626"/>
            <dbReference type="Rhea" id="RHEA-COMP:9627"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78451"/>
            <dbReference type="ChEBI" id="CHEBI:78453"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:41809"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(3R)-hydroxydecanoyl-[ACP] = (2E)-decenoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:41860"/>
            <dbReference type="Rhea" id="RHEA-COMP:9638"/>
            <dbReference type="Rhea" id="RHEA-COMP:9639"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78466"/>
            <dbReference type="ChEBI" id="CHEBI:78467"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:41861"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(3R)-hydroxydodecanoyl-[ACP] = (2E)-dodecenoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:41876"/>
            <dbReference type="Rhea" id="RHEA-COMP:9642"/>
            <dbReference type="Rhea" id="RHEA-COMP:9643"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78470"/>
            <dbReference type="ChEBI" id="CHEBI:78472"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:41877"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>(3R)-hydroxyhexadecanoyl-[ACP] = (2E)-hexadecenoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:41908"/>
            <dbReference type="Rhea" id="RHEA-COMP:9650"/>
            <dbReference type="Rhea" id="RHEA-COMP:9651"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78480"/>
            <dbReference type="ChEBI" id="CHEBI:78481"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:41909"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(3R)-hydroxyhexanoyl-[ACP] = (2E)-hexenoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:41828"/>
            <dbReference type="Rhea" id="RHEA-COMP:9630"/>
            <dbReference type="Rhea" id="RHEA-COMP:9631"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78457"/>
            <dbReference type="ChEBI" id="CHEBI:78458"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:41829"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>(3R)-hydroxyoctadecanoyl-[ACP] = (2E)-octadecenoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:41924"/>
            <dbReference type="Rhea" id="RHEA-COMP:9654"/>
            <dbReference type="Rhea" id="RHEA-COMP:9655"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78488"/>
            <dbReference type="ChEBI" id="CHEBI:78489"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:41925"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(3R)-hydroxyoctanoyl-[ACP] = (2E)-octenoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:41844"/>
            <dbReference type="Rhea" id="RHEA-COMP:9634"/>
            <dbReference type="Rhea" id="RHEA-COMP:9635"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78461"/>
            <dbReference type="ChEBI" id="CHEBI:78462"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:41845"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(3R)-hydroxytetradecanoyl-[ACP] = (2E)-tetradecenoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:41892"/>
            <dbReference type="Rhea" id="RHEA-COMP:9646"/>
            <dbReference type="Rhea" id="RHEA-COMP:9647"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78474"/>
            <dbReference type="ChEBI" id="CHEBI:78475"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:41893"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>3-oxobutanoyl-[ACP] + NADPH + H(+) = (3R)-hydroxybutanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41804"/>
            <dbReference type="Rhea" id="RHEA-COMP:9625"/>
            <dbReference type="Rhea" id="RHEA-COMP:9626"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78450"/>
            <dbReference type="ChEBI" id="CHEBI:78451"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="28">
            <dbReference type="Rhea" id="RHEA:41805"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>3-oxodecanoyl-[ACP] + NADPH + H(+) = (3R)-hydroxydecanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41856"/>
            <dbReference type="Rhea" id="RHEA-COMP:9637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9638"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78464"/>
            <dbReference type="ChEBI" id="CHEBI:78466"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:41857"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="43">
            <text>3-oxododecanoyl-[ACP] + NADPH + H(+) = (3R)-hydroxydodecanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41872"/>
            <dbReference type="Rhea" id="RHEA-COMP:9641"/>
            <dbReference type="Rhea" id="RHEA-COMP:9642"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78469"/>
            <dbReference type="ChEBI" id="CHEBI:78470"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="43">
            <dbReference type="Rhea" id="RHEA:41873"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="44">
            <text>3-oxohexadecanoyl-[ACP] + NADPH + H(+) = (3R)-hydroxyhexadecanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41904"/>
            <dbReference type="Rhea" id="RHEA-COMP:9649"/>
            <dbReference type="Rhea" id="RHEA-COMP:9650"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78478"/>
            <dbReference type="ChEBI" id="CHEBI:78480"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="44">
            <dbReference type="Rhea" id="RHEA:41905"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="35">
            <text>3-oxohexanoyl-[ACP] + NADPH + H(+) = (3R)-hydroxyhexanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41824"/>
            <dbReference type="Rhea" id="RHEA-COMP:9629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9630"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78456"/>
            <dbReference type="ChEBI" id="CHEBI:78457"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="35">
            <dbReference type="Rhea" id="RHEA:41825"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>3-oxooctadecanoyl-[ACP] + NADPH + H(+) = (3R)-hydroxyoctadecanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41920"/>
            <dbReference type="Rhea" id="RHEA-COMP:9653"/>
            <dbReference type="Rhea" id="RHEA-COMP:9654"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78487"/>
            <dbReference type="ChEBI" id="CHEBI:78488"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:41921"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="45">
            <text>3-oxooctanoyl-[ACP] + NADPH + H(+) = (3R)-hydroxyoctanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41840"/>
            <dbReference type="Rhea" id="RHEA-COMP:9633"/>
            <dbReference type="Rhea" id="RHEA-COMP:9634"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78460"/>
            <dbReference type="ChEBI" id="CHEBI:78461"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="45">
            <dbReference type="Rhea" id="RHEA:41841"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="39">
            <text>3-oxotetradecanoyl-[ACP] + NADPH + H(+) = (3R)-hydroxytetradecanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41888"/>
            <dbReference type="Rhea" id="RHEA-COMP:9645"/>
            <dbReference type="Rhea" id="RHEA-COMP:9646"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78473"/>
            <dbReference type="ChEBI" id="CHEBI:78474"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="39">
            <dbReference type="Rhea" id="RHEA:41889"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>a (3R)-hydroxyacyl-[ACP] + NADP(+) = a 3-oxoacyl-[ACP] + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17397"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="1.1.1.100"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="21">
            <dbReference type="Rhea" id="RHEA:17399"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a (3R)-hydroxyacyl-[ACP] = a (2E)-enoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:13097"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="4.2.1.59"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:13098"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="36">
            <text>a 2,3-saturated acyl-[ACP] + NADP(+) = a (2E)-enoyl-[ACP] + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22564"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9926"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78785"/>
            <dbReference type="EC" id="1.3.1.39"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="36">
            <dbReference type="Rhea" id="RHEA:22566"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="34">
            <text>a fatty acyl-[ACP] + malonyl-[ACP] + H(+) = a 3-oxoacyl-[ACP] + holo-[ACP] + CO2</text>
            <dbReference type="Rhea" id="RHEA:22836"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:14125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:138651"/>
            <dbReference type="EC" id="2.3.1.41"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="34">
            <dbReference type="Rhea" id="RHEA:22837"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>acetyl-[ACP] + malonyl-[ACP] + H(+) = 3-oxobutanoyl-[ACP] + holo-[ACP] + CO2</text>
            <dbReference type="Rhea" id="RHEA:41800"/>
            <dbReference type="Rhea" id="RHEA-COMP:9621"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9625"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78446"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78450"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="29">
            <dbReference type="Rhea" id="RHEA:41801"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="46">
            <text>butanoyl-[ACP] + malonyl-[ACP] + H(+) = 3-oxohexanoyl-[ACP] + holo-[ACP] + CO2</text>
            <dbReference type="Rhea" id="RHEA:41820"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9628"/>
            <dbReference type="Rhea" id="RHEA-COMP:9629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78454"/>
            <dbReference type="ChEBI" id="CHEBI:78456"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="46">
            <dbReference type="Rhea" id="RHEA:41821"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="41">
            <text>decanoyl-[ACP] + malonyl-[ACP] + H(+) = 3-oxododecanoyl-[ACP] + holo-[ACP] + CO2</text>
            <dbReference type="Rhea" id="RHEA:41868"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9640"/>
            <dbReference type="Rhea" id="RHEA-COMP:9641"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78468"/>
            <dbReference type="ChEBI" id="CHEBI:78469"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="41">
            <dbReference type="Rhea" id="RHEA:41869"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>dodecanoyl-[ACP] + malonyl-[ACP] + H(+) = 3-oxotetradecanoyl-[ACP] + holo-[ACP] + CO2</text>
            <dbReference type="Rhea" id="RHEA:41884"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9644"/>
            <dbReference type="Rhea" id="RHEA-COMP:9645"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:65264"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78473"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:41885"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="38">
            <text>hexadecanoyl-[ACP] + H2O = hexadecanoate + holo-[ACP] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41932"/>
            <dbReference type="Rhea" id="RHEA-COMP:9652"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78483"/>
            <dbReference type="EC" id="3.1.2.14"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="38">
            <dbReference type="Rhea" id="RHEA:41933"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="30">
            <text>hexadecanoyl-[ACP] + malonyl-[ACP] + H(+) = 3-oxooctadecanoyl-[ACP] + holo-[ACP] + CO2</text>
            <dbReference type="Rhea" id="RHEA:41916"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9652"/>
            <dbReference type="Rhea" id="RHEA-COMP:9653"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78483"/>
            <dbReference type="ChEBI" id="CHEBI:78487"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="30">
            <dbReference type="Rhea" id="RHEA:41917"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>hexanoyl-[ACP] + malonyl-[ACP] + H(+) = 3-oxooctanoyl-[ACP] + holo-[ACP] + CO2</text>
            <dbReference type="Rhea" id="RHEA:41836"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9632"/>
            <dbReference type="Rhea" id="RHEA-COMP:9633"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78459"/>
            <dbReference type="ChEBI" id="CHEBI:78460"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:41837"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="37">
            <text>holo-[ACP] + acetyl-CoA = acetyl-[ACP] + CoA</text>
            <dbReference type="Rhea" id="RHEA:41788"/>
            <dbReference type="Rhea" id="RHEA-COMP:9621"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78446"/>
            <dbReference type="EC" id="2.3.1.38"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="37">
            <dbReference type="Rhea" id="RHEA:41789"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="48">
            <text>octanoyl-[ACP] + malonyl-[ACP] + H(+) = 3-oxodecanoyl-[ACP] + holo-[ACP] + CO2</text>
            <dbReference type="Rhea" id="RHEA:41852"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9636"/>
            <dbReference type="Rhea" id="RHEA-COMP:9637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78463"/>
            <dbReference type="ChEBI" id="CHEBI:78464"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="48">
            <dbReference type="Rhea" id="RHEA:41853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="32">
            <text>tetradecanoyl-[ACP] + H2O = tetradecanoate + holo-[ACP] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:30123"/>
            <dbReference type="Rhea" id="RHEA-COMP:9648"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30807"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78477"/>
            <dbReference type="EC" id="3.1.2.14"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="32">
            <dbReference type="Rhea" id="RHEA:30124"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>tetradecanoyl-[ACP] + malonyl-[ACP] + H(+) = 3-oxohexadecanoyl-[ACP] + holo-[ACP] + CO2</text>
            <dbReference type="Rhea" id="RHEA:41900"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9648"/>
            <dbReference type="Rhea" id="RHEA-COMP:9649"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78477"/>
            <dbReference type="ChEBI" id="CHEBI:78478"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:41901"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="caution">
        <text evidence="51">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A1S6"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019171">
        <property type="term" value="F:(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004313">
        <property type="term" value="F:[acyl-carrier-protein] S-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141148">
        <property type="term" value="F:enoyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016297">
        <property type="term" value="F:fatty acyl-[ACP] hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08954">
        <property type="entry name" value="KR_1_FAS_SDR_x"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049391">
        <property type="entry name" value="FAS_pseudo-KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF23">
        <property type="entry name" value="FATTY ACID SYNTHASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21149">
        <property type="entry name" value="FAS_pseudo-KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="2" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="52" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0702">S-nitrosylation</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="50">
        <location>
            <begin position="1"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="49">
        <location>
            <begin position="1825"/>
            <end position="1907"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00047300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00047400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00047440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00047451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00047500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00047578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00047810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00047897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00047953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00047961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00048051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00048281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="ARBA" id="ARBA00048289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="ARBA" id="ARBA00048420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="34">
        <source>
            <dbReference type="ARBA" id="ARBA00048506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="35">
        <source>
            <dbReference type="ARBA" id="ARBA00048571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="36">
        <source>
            <dbReference type="ARBA" id="ARBA00048650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="37">
        <source>
            <dbReference type="ARBA" id="ARBA00048691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="38">
        <source>
            <dbReference type="ARBA" id="ARBA00048704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="39">
        <source>
            <dbReference type="ARBA" id="ARBA00048935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="40">
        <source>
            <dbReference type="ARBA" id="ARBA00049019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="41">
        <source>
            <dbReference type="ARBA" id="ARBA00049109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="42">
        <source>
            <dbReference type="ARBA" id="ARBA00049171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="43">
        <source>
            <dbReference type="ARBA" id="ARBA00049263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="44">
        <source>
            <dbReference type="ARBA" id="ARBA00049414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="45">
        <source>
            <dbReference type="ARBA" id="ARBA00049422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="46">
        <source>
            <dbReference type="ARBA" id="ARBA00049449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="47">
        <source>
            <dbReference type="ARBA" id="ARBA00049521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="48">
        <source>
            <dbReference type="ARBA" id="ARBA00049533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="49">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="50">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="51">
        <source>
            <dbReference type="EMBL" id="KAB0791218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="52">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="2192" mass="243618" checksum="6F4996A604010E6E" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A285</accession>
    <name>A0A5N4A285_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_03206</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A285"/>
    <dbReference type="InParanoid" id="A0A5N4A285"/>
    <dbReference type="OrthoDB" id="6147874at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000068">
        <property type="entry name" value="transmembrane protease serine 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051333">
        <property type="entry name" value="CLIP_Serine_Protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031986">
        <property type="entry name" value="GD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24260:SF143">
        <property type="entry name" value="SERINE PROTEASE GD-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16030">
        <property type="entry name" value="GD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024391333" description="Peptidase S1 domain-containing protein" evidence="2">
        <location>
            <begin position="16"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="3">
        <location>
            <begin position="196"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0791406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="451" mass="50396" checksum="339A02ECDFCCDB7E" modified="2020-02-26" version="1">MKLCALLLTAAFCQCAGNVLLEVSPCPRLFVYERTSSYNDRWFGIITLLNDATLNGIWLRVSFDRPIIQLGNWFGEVVKKSTTEYVIKNPNFNLKAHTPKIVRIFVKYNVNAPPPQVVGFKLNARTVCPEEVVSTTPSTTTEHLFTNSEDQVTPDLGSRNNVMSTDDSTTELNFNEQPLFISHLKPHSNPTSTCGTISTQPSNAQPQIAYKGQFPWHVALYYTKDVTIAYLCGASLISPDHIVTVAHCVVKGSTQTAVNPDRLVAYMGKYFLKHWTQEGTQTRYISKISPHPNYKSETNANDIALLRLTNSVEFTDIIRPVCLWTEEVGTNVGSVVGWGFDEIGRIEEKLMYVQMAIQGEDTCNVSVANYSVKFNNDLTYCASFLEDTLECVGDSGGGMVFRTDDGIWQLRGIVTVSVVLQHQLKCGPQQYAVFTDVSKYHSWIKETLAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-06-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A2A0</accession>
    <name>A0A5N4A2A0_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_03253</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A2A0"/>
    <dbReference type="InParanoid" id="A0A5N4A2A0"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024443882" evidence="1">
        <location>
            <begin position="20"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0791453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="160" mass="18326" checksum="4F7949C45B789709" modified="2020-02-26" version="1">MKVALYALLMFAIGAYCNCGCLNCNKQFHVISPPGAKVQIIHKKIHHCTCPTAIPYTVEIPVAPKAETHWARSYGYQIHPERLVVRKPHVYCPIPEEYDAQLQIPDEETPRRPTYLKNLYAHTDRVIICEPPRHHLPKVCSPPILEKLGGRSPYPRAERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A2D1</accession>
    <name>A0A5N4A2D1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Coronin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PPYR_03285</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat coronin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A2D1"/>
    <dbReference type="FunCoup" id="A0A5N4A2D1">
        <property type="interactions" value="744"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A2D1"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015505">
        <property type="entry name" value="Coronin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10856">
        <property type="entry name" value="CORONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10856:SF0">
        <property type="entry name" value="CORONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16300">
        <property type="entry name" value="WD40_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01167">
        <property type="entry name" value="DUF1900"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="14"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="64"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="348"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="403"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU280818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0791485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="428" mass="47266" checksum="C7036C89EDACD5E8" modified="2020-02-26" version="1">MIIAGRIAADHPLVGGHKGPVLDIAFCPHNDNVIASGSEDCVVKVWHIPDHGLVKTLTEPIVDLLYHQRRVGLVLWHPTALNVLLTAGSDNQVVIWNVGTGEALVHIDCHPDIIYSACFNWDGSQLLTTCKDKKIRIINPRTGVIESDAVCHEGSKATRAIFLRHGLVFTTGFSKMSERQYSLRTPDMLSEPIVMVELDTSNGVMFPLYDADTNLIYLCGKGDSVIRYFEITPEPPFVHYINTFQTPDPQRGIGMMPKRGCDVSICEISRFYRLTNSGLCQVITMTVPRKSELFQEDLYPDTIGDSSACTAEEWMEGKDVDPILISLKDGYKPPEAKISISVNRRRNVLDKGSGKSSKEAAKPQPEVSDKTLQDFADEIRKLKAMIVKHENRIRALEAEVALSKSNVDEDGPGGDGLNAVPPMASDEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A2E8</accession>
    <name>A0A5N4A2E8_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_03304</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000011">
        <property type="protein sequence ID" value="KAB0791504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A2E8"/>
    <dbReference type="InParanoid" id="A0A5N4A2E8"/>
    <dbReference type="OrthoDB" id="6426920at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="419"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="457"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="553"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="458"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="553"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0791504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="763" mass="85740" checksum="16027DED7D8F3AE7" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A3V9</accession>
    <name>A0A5N4A3V9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PPYR_08685</name>
        <name evidence="9" type="ORF">PPYR_13943</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">1611_PpyrPB1</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DAMOX/DASOX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0791982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A3V9"/>
    <dbReference type="FunCoup" id="A0A5N4A3V9">
        <property type="interactions" value="155"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A3V9"/>
    <dbReference type="OrthoDB" id="2015447at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003884">
        <property type="term" value="F:D-amino-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019478">
        <property type="term" value="P:D-amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006181">
        <property type="entry name" value="D-amino_acid_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023209">
        <property type="entry name" value="DAO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530">
        <property type="entry name" value="D-AMINO ACID OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530:SF11">
        <property type="entry name" value="D-ASPARTATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000189">
        <property type="entry name" value="D-aa_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00677">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="8">
        <location>
            <begin position="4"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="35"/>
            <end position="36"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="47"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="305"/>
            <end position="310"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000189-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAB0791982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAB0797692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="335" mass="36417" checksum="DEF03311079BB874" modified="2020-02-26" version="1">MYNIAILGGGVIGLTTAAVLQDRLSSTANITVYADRLSPNTTGDVSAGLWTLFLIQDPDLDKILAWGRRTYEWVLQLWKAGHAGEAGIALQPVKLLLNDGTQSKNASVVFGECPMAKVQVEEVNKALQVEFQAGVNYVTFTCQMTKYLPFLQRRFVQEGGKIVVRRVDSLNQLGEYDAIVNCSGMDASSLVGDDQMSPIRGQVIKVEAPWQFSTVLAGGSYVIVNEESTVLGGTAQIGDYGQDVRSSDSEKILRNCTKLVPSLKNTKVIAHMAGLRPGRTRVRLETEIKEIAGRRLPVIHNYGHGGSGVTLSYGCALSTLQLVKEALKINLKSKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A3W7</accession>
    <name>A0A5N4A3W7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UDP-glucuronosyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PPYR_13986</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:132367"/>
            <dbReference type="ChEBI" id="CHEBI:132368"/>
            <dbReference type="EC" id="2.4.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Membrane</location>
            <topology evidence="5">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.17" evidence="5"/>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A3W7"/>
    <dbReference type="InParanoid" id="A0A5N4A3W7"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015020">
        <property type="term" value="F:glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000021">
        <property type="entry name" value="UDP-glucuronosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035595">
        <property type="entry name" value="UDP_glycos_trans_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF159">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00375">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024480720" description="UDP-glucuronosyltransferase" evidence="5">
        <location>
            <begin position="19"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="471"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0792025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="505" mass="57526" checksum="264BCCA4312D9772" modified="2020-02-26" version="1">MLLKLCLFGFAFCSVSQCARILVIVPTPSHSHHVATQPIWKELCLRGHQVTSLTTVPINDPKLTNLTEIDISFSNSAWHKDLKEIVASNHFLTYINTYVALANSCDVQLAHPSIQALIKSKNESFDLVITESTRPAYFAFAQKFNCPSIGINTLDASPSIYSALGNPTHPLLYPDYWISYVNDLSLFQRIFSVVHYAFIMVCEKMLLMPMYQEITNRHFGSEYPPLEQLIANMSLLLVNSESVFRTIRPRTPNIIPIGGNLIRLPAKPLPKDLKEALDNAKNGFIYFSLGSNVKSNFLDDRVRDDIMGAFRELPYLVVWKLDTDSLPNNPKNVLLYPWVPQLAVLNHPNLKLFITHGGLQSMTESIYANVPMLGIPFFADQDRNVQEMVAKGYGVYLDHRQIEKRRLVQTILEVITNPKYRSKLKELAELSIDQPMTGLERAVWWIEYVLRHKGAKHLQSPAISLPFYQHYFLDVIAVLVLIVFGTMYTLCRLRRAVFSKRVKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A4B3</accession>
    <name>A0A5N4A4B3_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_14119</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A4B3"/>
    <dbReference type="InParanoid" id="A0A5N4A4B3"/>
    <dbReference type="OrthoDB" id="3561125at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050688">
        <property type="entry name" value="Zinc_finger/UBP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24403:SF67">
        <property type="entry name" value="FI01116P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24403">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13909">
        <property type="entry name" value="zf-H2C2_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="96"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="124"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="152"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="236"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="270"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0792160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="307" mass="36425" checksum="59BDD6B15DDEF455" modified="2020-02-26" version="1">MFSGDAVDKPIIKDEVKVEEDAPEIIGGSHEMVEARTIQDFCKVEVYERYSAPSPKEATPKLEDLVLHKCFQCGFTTKWRKNLNSHLRMHDTLEIFNCERCDFTTKYKRNFTRHLQGHSGLEEFKCEQCDFATKHKRNFTRHVQAHHGLTRFTCNRCDFATKHKRNLIRHTETHHGLKKFNCRKCAFSTTCEINFTKHVTVHCSSKKFQCDQCNFSTKYERNLTRHVQTHQQLEVFNCNFCEFVTKLKTYLLRHVRRQHMGTKRQMSREFRCEQCSFATRWKTNLISHWRQLHVLESASRGENEGLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A4W0</accession>
    <name>A0A5N4A4W0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Cyclin-dependent kinase 10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">Cell division protein kinase 10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="28" type="ORF">PPYR_14333</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="28 29" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28">1611_PpyrPB1</strain>
            <tissue evidence="28">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Cyclin-dependent kinase that phosphorylates the transcription factor ETS2 (in vitro) and positively controls its proteasomal degradation (in cells). Involved in the regulation of actin cytoskeleton organization through the phosphorylation of actin dynamics regulators such as PKN2. Is a negative regulator of ciliogenesis through phosphorylation of PKN2 and promotion of RhoA signaling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="19">Heterodimer with CCNQ, the interaction is required for kinase activity. Interacts with ETS2. Interacts with PRK2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 23">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="28">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A4W0"/>
    <dbReference type="InParanoid" id="A0A5N4A4W0"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030030">
        <property type="term" value="P:cell projection organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14978">
        <property type="entry name" value="7tmA_FMRFamide_R-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07845">
        <property type="entry name" value="STKc_CDK10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000289">
        <property type="entry name" value="cyclin-dependent kinase 10 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000256">
        <property type="entry name" value="cyclin-dependent kinase 10 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053093">
        <property type="entry name" value="GPCR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044093">
        <property type="entry name" value="STKc_CDK10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47760">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR B0563.6-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47760:SF1">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 22" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="17" id="KW-0966">Cell projection</keyword>
    <keyword evidence="12" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="16" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="23" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="15 25" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 22" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-0675">Receptor</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="23" id="KW-0807">Transducer</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 23 25" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 25" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="81"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="27">
        <location>
            <begin position="62"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="26">
        <location>
            <begin position="427"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="359"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="24">
        <location>
            <begin position="363"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="456"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00059360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00064010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00069133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00081094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EMBL" id="KAB0792374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="773" mass="86998" checksum="6310F5E1F70ACF8D" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A616</accession>
    <name>A0A5N4A616_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_14722</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000010">
        <property type="protein sequence ID" value="KAB0792763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A616"/>
    <dbReference type="InParanoid" id="A0A5N4A616"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0792763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="147" mass="16611" checksum="18E789813DCE4A7C" modified="2020-02-26" version="1">MQRVLSGQTAGCIETSEEVVSKRLCFSFVIVCAFFSVVGGFFLGRYTKDHDISHRCSDERITPYSTVVDSLTNSAKKINNLTLPLSLLSTYQVFNCSELYSNICYKCELCCSGNNTFNVSEVILYNLKRLEIYYFNISVLVDSLVMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A737</accession>
    <name>A0A5N4A737_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Pickpocket protein 28</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PPYR_12752</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">1611_PpyrPB1</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A737"/>
    <dbReference type="InParanoid" id="A0A5N4A737"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015280">
        <property type="term" value="F:ligand-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.820">
        <property type="entry name" value="Acid-sensing ion channel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.770">
        <property type="entry name" value="YojJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020903">
        <property type="entry name" value="ENaC_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF288">
        <property type="entry name" value="AMILORIDE-SENSITIVE NA+ CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01078">
        <property type="entry name" value="AMINACHANNEL"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01206">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="4 12" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="10 12" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="485"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAB0793132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="545" mass="62516" checksum="09C052FADA11D905" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A8B5</accession>
    <name>A0A5N4A8B5_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_13191</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A8B5"/>
    <dbReference type="InParanoid" id="A0A5N4A8B5"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF149">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="5">
        <location>
            <begin position="57"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="6">
        <location>
            <begin position="452"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0793571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="521" mass="57138" checksum="C42B8E6626932718" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A8H2</accession>
    <name>A0A5N4A8H2_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PPYR_13240</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A8H2"/>
    <dbReference type="FunCoup" id="A0A5N4A8H2">
        <property type="interactions" value="963"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4A8H2"/>
    <dbReference type="OrthoDB" id="79940at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15739">
        <property type="entry name" value="FYVE_RABE_unchar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.730:FF:000005">
        <property type="entry name" value="RABaptiN (Rab effector)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.730">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003914">
        <property type="entry name" value="Rabaptin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015390">
        <property type="entry name" value="Rabaptin_Rab5-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31179:SF7">
        <property type="entry name" value="FYVE-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31179">
        <property type="entry name" value="RAB GTPASE-BINDING EFFECTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09311">
        <property type="entry name" value="Rab5-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103652">
        <property type="entry name" value="G protein-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="7">
        <location>
            <begin position="554"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="11"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="204"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="286"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="431"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="145"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0793620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="629" mass="72391" checksum="02397A1CA624B9E3" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4A9D1</accession>
    <name>A0A5N4A9D1_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Leucine-rich repeat-containing protein 27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_13556</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000009">
        <property type="protein sequence ID" value="KAB0793936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4A9D1"/>
    <dbReference type="InParanoid" id="A0A5N4A9D1"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050333">
        <property type="entry name" value="SLRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45712">
        <property type="entry name" value="AGAP008170-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45712:SF22">
        <property type="entry name" value="INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN COMPLEX ACID LABILE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0793936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="412" mass="47892" checksum="A75BAB5787404A82" modified="2020-02-26" version="1">MRFMDVMVTNKVASTSLLHVKLKISKMSLIEVISDQANKKLEKVPESIMQMCNLKMLYLENNELFNLPDDFFAKLPKLTWIDLRKNKLTALPSGMADHANLETILLQNNLIQKLPNELGAIPNLKVLQVSGNPLTYPPHEVTDKGIVAISNFLREQYFLTRAQSDADAKIDAISNASSKSEISSDKEYKVSVDNERQSQREVKFMPVIDVKRLTENETNQKNTVTNVVKRTHKITRGCSKISLQSHSTWNNKRKIERAQEGEMKEIWLKRLKDILADQEKILQQERNLKALSKWRLKKKLEPVREVNLNDLSEPPFDTDPEYQRMLTRQDLNEQIDALVQKTKRIRKMRRHAKRVNIQELIDDVVNQMRYLQTQAEQSKSPRTDQEIAGKQIESIVKLHKKIVELQTQNERY</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AAT7</accession>
    <name>A0A5N4AAT7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tetraspanin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PPYR_11207</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">1611_PpyrPB1</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the tetraspanin (TM4SF) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0794368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AAT7"/>
    <dbReference type="FunCoup" id="A0A5N4AAT7">
        <property type="interactions" value="143"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AAT7"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03127">
        <property type="entry name" value="tetraspanin_LEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1450.10">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000301">
        <property type="entry name" value="Tetraspanin_animals"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018503">
        <property type="entry name" value="Tetraspanin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282:SF544">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002419">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00259">
        <property type="entry name" value="TMFOUR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00421">
        <property type="entry name" value="TM4_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="187"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="139"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR002419-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0794368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="215" mass="23014" checksum="7D0D4E447868A7D6" modified="2020-02-26" version="1">MLSVCNILNLAGIAFIAVGAVYLLDIKSVTAAVDRTGIPFSVAPTLLLVVGIVVFVISFLGCCGAVKESYCLLITYGVILLVLFLLQVGIGAYAFMQLKDSDGADKVSIENELRTTMREYPHSNQAQATFDTLQGQLKCCGVRGPSDWNGVTVPLSCCEWGPTQCYLANAYQDGCFPILYSFLHQSITIIGIIFVTIGGIELLGAICAFCLCCSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ABZ8</accession>
    <name>A0A5N4ABZ8_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cuticle protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_11671</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0794832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ABZ8"/>
    <dbReference type="InParanoid" id="A0A5N4ABZ8"/>
    <dbReference type="OrthoDB" id="10071059at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051217">
        <property type="entry name" value="Insect_Cuticle_Struc_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236:SF75">
        <property type="entry name" value="CUTICULAR PROTEIN 62BB, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236">
        <property type="entry name" value="STRUCTURAL CONTITUENT OF CUTICLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00947">
        <property type="entry name" value="CUTICLE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024438031" description="Cuticle protein" evidence="3">
        <location>
            <begin position="18"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0794832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="219" mass="22433" checksum="BE873993CEB32952" modified="2020-02-26" version="1">MALQFVVLAVFIAAANAGGLAPVAYSAYSSPVASYSYSSPLAYAAAPIAKVAAPLAYAAPVAKLAAPLAYAAPAPLSYAAPAPIAYAAHLPRVAAPLHYAAPAPLAYATPAIAKVAAPLAVAKTVVAEDFDPNPQYSFAYNVQDHLTGDSKSQHETRNGDYVEGSYSVADPDGSNRIVDYTADPVNGFNAIVRKEPLVAKIAVAPVAKYAAPLAIAKLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ADI0</accession>
    <name>A0A5N4ADI0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serpin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PPYR_05407</name>
        <name evidence="7" type="ORF">PPYR_12226</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2019-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Photinus pyralis genome working group"/>
                <person name="Fallon T.R."/>
                <person name="Sander Lower S.E."/>
                <person name="Weng J.-K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the serpin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000008">
        <property type="protein sequence ID" value="KAB0795387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="VVIM01000003">
        <property type="protein sequence ID" value="KAB0801053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ADI0"/>
    <dbReference type="InParanoid" id="A0A5N4ADI0"/>
    <dbReference type="OrthoDB" id="671595at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.39.10">
        <property type="entry name" value="Alpha-1-antitrypsin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.497.10">
        <property type="entry name" value="Antithrombin, subunit I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023795">
        <property type="entry name" value="Serpin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023796">
        <property type="entry name" value="Serpin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000215">
        <property type="entry name" value="Serpin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036186">
        <property type="entry name" value="Serpin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042178">
        <property type="entry name" value="Serpin_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042185">
        <property type="entry name" value="Serpin_sf_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461:SF211">
        <property type="entry name" value="GH10112P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR, SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00079">
        <property type="entry name" value="Serpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00093">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56574">
        <property type="entry name" value="Serpins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00284">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033857003" description="Serpin domain-containing protein" evidence="5">
        <location>
            <begin position="21"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="Serpin" evidence="6">
        <location>
            <begin position="34"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0795387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAB0801053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="392" mass="44502" checksum="0DFF32BC778305D1" modified="2020-02-26" version="1">MFHLATILLCLSATFIKIDALSEEFKRINVLFTADLYKELLKTNPENFVVCPLSIETVLAMLHAGAGGRTAKELADGSKVPDNSIKVQNLFKELKLQEEQLYTLRSVNKLYLANRFSINGNYREIVRNVFKAEIENVNFSNNENAARTINYWVENQTRNKIKDLIKAEYLGPYTVSVLVNTIYFNADWLDPFDSLLTKESRFHLNRAQQVDVEMMRTVLETPIYVNDELGATFLELPYKGEDVSMTFVLPQEFEGMPRLEANMQEVLKRQPFDDVRQVTIAIPKFKMETSISLEPILKNLGIRDAFTGSANFSAMTINDHNVFLTRVEQKAFIEVTEKGTTAGAATFAISEDRSFGATFIANRPFIYILRHNTNGILFVGKFSNPVGTKVSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AEY0</accession>
    <name>A0A5N4AEY0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Attacin C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_09917</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0795856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AEY0"/>
    <dbReference type="InParanoid" id="A0A5N4AEY0"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024299664" description="Attacin C-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0795856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="199" mass="20134" checksum="81C317E800235666" modified="2020-02-26" version="1">MVKHVFRLFLAVAIVSQTMAQLCGGVDILPSGGIGGTGSYKNGPAWGSVSGSYDGRRLGPVDVSGGAHFKLPNDGFAGAQASVQPGVGGTSSLYGKVNIFDTPTHRLDVQGHHDRILNRDLKPVGPAVNEVGANYKHVGGATAHIVASKVGSGPIQGSLGASVPLVSTPQGGINLGVKAIAGEGMKPQGEIGVVGEFKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AFQ7</accession>
    <name>A0A5N4AFQ7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">tRNA-t(6)A37 methylthiotransferase</fullName>
            <ecNumber evidence="15">2.8.4.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PPYR_10205</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">1611_PpyrPB1</strain>
            <tissue evidence="19">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 15">Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:37075"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="Rhea" id="RHEA-COMP:11092"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:74420"/>
            <dbReference type="EC" id="2.8.4.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="15">Binds 1 or 2 [4Fe-4S] cluster. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Endoplasmic reticulum membrane</location>
            <topology evidence="15">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the methylthiotransferase family. CDKAL1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.4.5" evidence="15"/>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AFQ7"/>
    <dbReference type="FunCoup" id="A0A5N4AFQ7">
        <property type="interactions" value="2021"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AFQ7"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035598">
        <property type="term" value="F:tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-methylthiotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12160:FF:000005">
        <property type="entry name" value="threonylcarbamoyladenosine tRNA methylthiotransferase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.30.20:FF:000002">
        <property type="entry name" value="threonylcarbamoyladenosine tRNA methylthiotransferase isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12160">
        <property type="entry name" value="Methylthiotransferase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="entry name" value="tm_1862 like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005839">
        <property type="entry name" value="Methylthiotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020612">
        <property type="entry name" value="Methylthiotransferase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013848">
        <property type="entry name" value="Methylthiotransferase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038135">
        <property type="entry name" value="Methylthiotransferase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006466">
        <property type="entry name" value="MiaB-like_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01578">
        <property type="entry name" value="MiaB-like-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00089">
        <property type="entry name" value="MiaB/RimO family radical SAM methylthiotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11918">
        <property type="entry name" value="RADICAL SAM PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11918:SF45">
        <property type="entry name" value="THREONYLCARBAMOYLADENOSINE TRNA METHYLTHIOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01938">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00919">
        <property type="entry name" value="UPF0004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01082">
        <property type="entry name" value="B12-binding_domain_containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51449">
        <property type="entry name" value="MTTASE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01278">
        <property type="entry name" value="MTTASE_RADICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 15" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="15" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11 15" id="KW-0408">Iron</keyword>
    <keyword evidence="12 15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8 15" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="MTTase N-terminal" evidence="17">
        <location>
            <begin position="58"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="18">
        <location>
            <begin position="194"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="TRAM" evidence="16">
        <location>
            <begin position="425"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00051661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU368081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAB0796144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="537" mass="60197" checksum="6605A12347B1FD43" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-06-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AGD6</accession>
    <name>A0A5N4AGD6_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PPYR_10456</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">1611_PpyrPB1</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000007">
        <property type="protein sequence ID" value="KAB0796395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AGD6"/>
    <dbReference type="InParanoid" id="A0A5N4AGD6"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024462138" evidence="1">
        <location>
            <begin position="18"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAB0796395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="108" mass="12752" checksum="43D00B6C9401CF63" modified="2020-02-26" version="1">MYFKLVIGLMCVGVISGVEHRYCHLCYGKSTEPKDFWNCRNFVNVTKVYDCTTKSYCVSFHETVKTKDGTYTWAKRTCSSDCAWYKRYNRADLYCSQCESDYCNKEKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2023-09-13" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AK03</accession>
    <name>A0A5N4AK03_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Integrase SAM-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_08675</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0797682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AK03"/>
    <dbReference type="InParanoid" id="A0A5N4AK03"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0797682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="164" mass="18617" checksum="97394CBEB85B8E15" modified="2020-02-26" version="1">MAELLAGPSNLHDDSSDSLICTPEEISEKAKEVTLQLLPNKSKKKYDIQYDLFMKWCATKHVKRYSESVVLAYLSELSAKYKSSTLWSIHSMLKATLSVRQNVDIGSYVKVNAFLKKQSVGHIPKTSKTFTSTEVNTFLRDAPDDIYLMLKVTCCSNNWNQRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AMM6</accession>
    <name>A0A5N4AMM6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Multidrug resistance-associated protein lethal(2)03659</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PPYR_09598</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">1611_PpyrPB1</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AMM6"/>
    <dbReference type="InParanoid" id="A0A5N4AMM6"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18579">
        <property type="entry name" value="ABC_6TM_ABCC_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000973">
        <property type="entry name" value="Multidrug resistance-associated protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000026">
        <property type="entry name" value="Multidrug resistance-associated protein lethal(2)03659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000014">
        <property type="entry name" value="Multidrug resistance-associated protein member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000163">
        <property type="entry name" value="Multidrug resistance-associated protein member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044746">
        <property type="entry name" value="ABCC_6TM_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF448">
        <property type="entry name" value="FI20146P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="242"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="318"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="358"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="693"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="752"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="823"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="850"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="935"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="101"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="417"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="697"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="1025"/>
            <end position="1254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAB0798605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1260" mass="142590" checksum="36EC7F8EC28BFF11" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AMW9</accession>
    <name>A0A5N4AMW9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA topoisomerase I</fullName>
            <ecNumber evidence="9">5.6.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">DNA topoisomerase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PPYR_09616</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">1611_PpyrPB1</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 9">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8 9">Belongs to the type IB topoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="9"/>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AMW9"/>
    <dbReference type="FunCoup" id="A0A5N4AMW9">
        <property type="interactions" value="1118"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AMW9"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
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    <dbReference type="PANTHER" id="PTHR10290:SF3">
        <property type="entry name" value="DNA TOPOISOMERASE 1"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF01028">
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        <property type="entry name" value="Topoisom_I_N"/>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="TOPO_IB_2"/>
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    </dbReference>
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    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 8 9" id="KW-0238">DNA-binding</keyword>
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    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 9" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="DNA topoisomerase I eukaryotic-type" evidence="12">
        <location>
            <begin position="623"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="126"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="573"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="906"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="130"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="155"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="315"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="328"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="351"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="386"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="400"/>
            <end position="419"/>
        </location>
    </feature>
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            <position position="984"/>
        </location>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006645"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAB0798623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1026" mass="120283" checksum="2A07066DDEB3E02A" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AN43</accession>
    <name>A0A5N4AN43_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">APCDD1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_06629</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0798749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017147">
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030178">
        <property type="term" value="P:negative regulation of Wnt signaling pathway"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    <dbReference type="InterPro" id="IPR029405">
        <property type="entry name" value="APCDD1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31021">
        <property type="entry name" value="ADENOMATOSIS POLYPOSIS COLI DOWN-REGULATED 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31021:SF1">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_56, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="APCDDC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <feature type="domain" description="APCDD1" evidence="6">
        <location>
            <begin position="77"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="APCDD1" evidence="6">
        <location>
            <begin position="334"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0798749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="566" mass="65053" checksum="02C1FA24DD5DBFC9" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AN44</accession>
    <name>A0A5N4AN44_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PPYR_09631</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">1611_PpyrPB1</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AN44"/>
    <dbReference type="FunCoup" id="A0A5N4AN44">
        <property type="interactions" value="2796"/>
    </dbReference>
    <dbReference type="InParanoid" id="A0A5N4AN44"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12283">
        <property type="entry name" value="RRM1_RBM39_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12284">
        <property type="entry name" value="RRM2_RBM23_RBM39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12285">
        <property type="entry name" value="RRM3_RBM39_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000080">
        <property type="entry name" value="RNA-binding protein 39 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000090">
        <property type="entry name" value="RNA-binding protein 39 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029123">
        <property type="entry name" value="RBM39_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006509">
        <property type="entry name" value="RBM39_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01622">
        <property type="entry name" value="SF-CC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48036">
        <property type="entry name" value="SPLICING FACTOR (PAD-1), PUTATIVE (AFU_ORTHOLOGUE AFUA_1G15810)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15519">
        <property type="entry name" value="RBM39linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="145"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="243"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="36"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="81"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="81"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAB0798638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="504" mass="55196" checksum="8DEF2E27B585544C" modified="2020-02-26" version="1">MAISEGVGHQTSVVPEAEVGVVPETDMEGEVGIARGAKAEEGPRIEGHGLGTEDEQNLETGVHGPKIDVVDLKIAVNNNFRRRRSRSRSRKRSASRDVGFRKRSPSPPSVRLPFPKKARSPIGLGYTNRTSPPLEELSPEERDARTVFVMQLSQRVRARDLQEFFSAVGKVRDVRLITCNKTRRFKGIAYIEFRDPESVTLALGLSGQKLSGIPIVVQHTQAEKNRMGNSMPNLMPKTMTGPMRLYVGSLHFNITEEMLRGIFEPFGKIDNIQLIMDPETGRSKGYGFITFHNCEDAKKALEQLNGFELAGRPMKVGNVTERLDLQSQGPSILDSDELDRSGIDLGATGRLQLMFKLAEGAGLRVPEAAANALSMATGQPVVPQIPTNSTPPIATQCFMLSNMFDPSSESAHSWDTEIRDDVIEECNKHGGVLHVYVDKGSPQGNVYVKCPSIATAVASVNSLHGRWFAGRVITAAYVPLLNYHSLFPDAMSAAQLLLPTGKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4AN82</accession>
    <name>A0A5N4AN82_PHOPY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PPYR_09671</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">1611_PpyrPB1</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000006">
        <property type="protein sequence ID" value="KAB0798678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4AN82"/>
    <dbReference type="InParanoid" id="A0A5N4AN82"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34239">
        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34239:SF2">
        <property type="entry name" value="TRANSPOSABLE ELEMENT P TRANSPOSASE_THAP9 CONSERVED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAB0798678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="272" mass="31174" checksum="396EC4690E796A07" modified="2020-02-26" version="1" fragment="single">ENESNTTVQDMPLSKDILKIIGVTEKQNQTDSFIRKELVASWLDIVKRRLSEDVRTECVLRYPPPTNCKFLEAPKLNVEVAAATNVASVNRDNRLLGFQKQLGCSISAIGRALSLLLEQDGNTNLQLVRSLSDAGKLLVDLFSSYSSTRKELLALGLSKEFKDTLHNAEVDDWLFGINLDERLRASKNLEKVSQELRPAKPKAPVAYREAKNSRGRSLFPRVRRDRQPFHQRTRPFYSARPKSLLEGRNLARMQLQQTRQQRRPVTKRPWQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ANE9</accession>
    <name>A0A5N4ANE9_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cuticle protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PPYR_06711</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">1611_PpyrPB1</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0798831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ANE9"/>
    <dbReference type="InParanoid" id="A0A5N4ANE9"/>
    <dbReference type="OrthoDB" id="6515429at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0193">Cuticle</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024403968" description="Cuticle protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAB0798831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="386" mass="41998" checksum="C835742FD9C1E412" modified="2020-02-26" version="1">MQILVAVFALISVAASEHAQVVNVKQDNIGNYQLKYDIDGISRVEQRTIDGNVNGAFSFIDPHGIVRKTVFMSGSHGFHAASPDIPTPVQDTPEVALAKSQHLEVLRGAHLANGKIVLPAEKIITAPLETVVIAKNVPETLLLRSSQIGLGEEKVLATKVLRTDEIATERLPIAEKFVQTSPILRTTQLAIDSPSLVKGEISLLRTDNNFKLEPVSFTDKLIQTSSPLVRIGQIAFESEKILGNTEKLVQTSVPLVRAVEAVPEKIVRTEIPVLKSADIQEILKPAVKTVETIPLVTSDKSEIPVFRTSVPITREFIKAEIPTLKSALTLGGLESLGVLKANLESPTYRVVELPVREIASHKLVTYGDKVQLVRIGNEGLAKVILQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4APC6</accession>
    <name>A0A5N4APC6_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Heat shock protein 70</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PPYR_07059</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">1611_PpyrPB1</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4APC6"/>
    <dbReference type="InParanoid" id="A0A5N4APC6"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000024">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000056">
        <property type="entry name" value="Protein CBG18239"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="136"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAB0799179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="162" mass="17807" checksum="F6D932557BE372A9" modified="2020-02-26" version="1">MDANGILNVSAKDTSSGKSQQITIKNDKGRLSQRDIDQMVADAEKYKEEDEKQRTRISASNQLEGYVFNLKQTLGDVGDKLSAEDKNVVQNACDGCLKWLDNNLLAEKEEYEDQQKQLTHLCSPIMSKLYANAGTQSGAMPGSCGEQAGRFNAQGPTIEEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ARP4</accession>
    <name>A0A5N4ARP4_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PPYR_07859</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">1611_PpyrPB1</strain>
            <tissue evidence="19">Whole body</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0799979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ARP4"/>
    <dbReference type="InParanoid" id="A0A5N4ARP4"/>
    <dbReference type="OrthoDB" id="10054666at2759"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005891">
        <property type="term" value="C:voltage-gated calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005245">
        <property type="term" value="F:voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051173">
        <property type="entry name" value="Ca_channel_alpha-2/delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013680">
        <property type="entry name" value="VDCC_a2/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013608">
        <property type="entry name" value="VWA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10166:SF63">
        <property type="entry name" value="STRAIGHTJACKET, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10166">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2/DELTA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08473">
        <property type="entry name" value="VGCC_alpha2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08399">
        <property type="entry name" value="VWA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="3" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15" id="KW-0407">Ion channel</keyword>
    <keyword evidence="11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 17" id="KW-0732">Signal</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5024467302" description="VWFA domain-containing protein" evidence="17">
        <location>
            <begin position="21"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1023"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="18">
        <location>
            <begin position="300"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAB0799979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="1191" mass="139861" checksum="C7A39A9E5955692A" modified="2020-02-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ART0</accession>
    <name>A0A5N4ART0_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PPYR_07935</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
            <taxon>Polyphaga</taxon>
            <taxon>Elateriformia</taxon>
            <taxon>Elateroidea</taxon>
            <taxon>Lampyridae</taxon>
            <taxon>Lampyrinae</taxon>
            <taxon>Photinus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Elife" volume="7" first="e36495" last="e36495">
            <title>Firefly genomes illuminate parallel origins of bioluminescence in beetles.</title>
            <authorList>
                <person name="Fallon T.R."/>
                <person name="Lower S.E."/>
                <person name="Chang C.H."/>
                <person name="Bessho-Uehara M."/>
                <person name="Martin G.J."/>
                <person name="Bewick A.J."/>
                <person name="Behringer M."/>
                <person name="Debat H.J."/>
                <person name="Wong I."/>
                <person name="Day J.C."/>
                <person name="Suvorov A."/>
                <person name="Silva C.J."/>
                <person name="Stanger-Hall K.F."/>
                <person name="Hall D.W."/>
                <person name="Schmitz R.J."/>
                <person name="Nelson D.R."/>
                <person name="Lewis S.M."/>
                <person name="Shigenobu S."/>
                <person name="Bybee S.M."/>
                <person name="Larracuente A.M."/>
                <person name="Oba Y."/>
                <person name="Weng J.K."/>
            </authorList>
            <dbReference type="PubMed" id="30324905"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">1611_PpyrPB1</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="VVIM01000005">
        <property type="protein sequence ID" value="KAB0800055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A5N4ART0"/>
    <dbReference type="InParanoid" id="A0A5N4ART0"/>
    <dbReference type="Proteomes" id="UP000327044">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF14">
        <property type="entry name" value="SERINE HYDROLASE-LIKE PROTEIN DDB_G0286239"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="27"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAB0800055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000327044"/>
        </source>
    </evidence>
    <sequence length="207" mass="23781" checksum="8EF54D805662EF6F" modified="2020-02-26" version="1">MDEQEFEIPVPWGHIAAKSWGNDKNQLVFMIHANSDNAGSFDRLILHLPDTFYYIAIDLPGHGKSSHFPSNIPLHEINYVLAVNMVVNYMNREKVILIGHCWGGQMAMLFSQFFPERVLRLVLIEAVYFSPVSVEYFKQYTREYIDNSITLLEKSKTRKPPVYSFDSAKHAMINARIYGKLKPEAAGPLLKRCLNPIGEDQYQITND</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A5N4ARZ7</accession>
    <name>A0A5N4ARZ7_PHOPY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA polymerase delta catalytic subunit</fullName>
            <ecNumber evidence="2">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PPYR_08002</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Photinus pyralis</name>
        <name type="common">Common eastern firefly</name>
        <name type="synonym">Lampyris pyralis</name>
        <dbReference type="NCBI Taxonomy" id="7054"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Coleoptera</taxon>
       